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• Hypersensitivity.
Brand name: Thorazine
•Cross-sensitivity may exist among
CLASSIFICATION: Antipsychotics
phenothiazines. Should not be used in
ACTION: narrow-angle glaucoma.
• Block dopamine receptors in the brain; •Should not be used in patients who have
also alter dopamine release and turnover. CNS depression.
• Prevention of seizures
NURSING CONSIDERATIONS:
INDICATION / USES: 1• Assess mental status prior to and
•Acute and chronic psychoses, particularly periodically during therapy.
when accompanied by increased 2• Monitor BP and pulse prior to and
psychomotor activity. Nausea and vomiting. frequently during the period of dosage
• Also used in the treatment of intractable adjustment. May cause QT interval changes
hiccups. on ECG.
3• Observe patient carefully when
COMMON ADVERSE EFFECTS: administering medication, to ensure that
•CNS: neuroleptic malignant syndrome, medication is actually taken and not
sedation, extrapyramidal reactions, tardive hoarded.
dyskinesia 4•Monitor I&O ratios and daily eight.
•CV: hypotension (increased with IM, IV) Assess patient for signs and symptoms of
•EENT: blurred vision, dry eyes, lens dehydration.
opacities 5• Monitor for development of neuroleptic
• GI: constipation, dry mouth, anorexia, malignant syndrome (fever, respiratory
hepatitis, ileus distress, tachycardia, seizures, diaphoresis,
• GU: urinary retention hypertension or hypotension, pallor,
• Hematologic: agranulocytosis, leukopenia tiredness, severe muscle stiffness, loss of
• Skin: photosensitivity, pigment changes, bladder control. Report symptoms
rashes immediately. May also cause leukocytosis,
elevated liver function tests, elevated CPK.
6• Advise patient to take medication as
directed. Take missed doses as soon as
remembered, witih remaining doses evenly
spaced through out the day. May require
several weeks to obtain desired effects. Do
not increase dose or discontinue medication
without consulting health care professional.
Abrupt withdrawal may cause dizziness,
nausea, vomiting, GI upset, trembling, or
uncontrolled movements of mouth, tongue
or jaw.
Clorpromazine ,haloperidol
,biperiden
clozapine carbamazepine