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    Cyclooxygenase-2 : Homo Sapiens

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    Aqsha Ramadhanisa
    This document contains the genomic sequence and annotation for the human cyclooxygenase-2 (COX-2) gene. It includes information on the gene name, protein domains, binding sites, and the amino acid sequence derived from the cDNA sequence. COX-2 is an enzyme involved in prostaglandin biosynthesis.

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    Cyclooxygenase-2 : Homo Sapiens

    Uploaded by

    Aqsha Ramadhanisa
    15 views3 pages
    This document contains the genomic sequence and annotation for the human cyclooxygenase-2 (COX-2) gene. It includes information on the gene name, protein domains, binding sites, and the amino acid sequence derived from the cDNA sequence. COX-2 is an enzyme involved in prostaglandin biosynthesis.

    Original Title

    cyclooxygenase

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    © Attribution Non-Commercial (BY-NC)

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    This document contains the genomic sequence and annotation for the human cyclooxygenase-2 (COX-2) gene. It includes information on the gene name, protein domains, binding sites, and the amino acid sequence derived from the cDNA sequence. COX-2 is an enzyme involved in prostaglandin biosynthesis.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    15 views3 pages

    Cyclooxygenase-2 : Homo Sapiens

    Uploaded by

    Aqsha Ramadhanisa
    This document contains the genomic sequence and annotation for the human cyclooxygenase-2 (COX-2) gene. It includes information on the gene name, protein domains, binding sites, and the amino acid sequence derived from the cDNA sequence. COX-2 is an enzyme involved in prostaglandin biosynthesis.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 3

    cyclooxygenase-2 [Homo sapiens]

    GenBank: AAA58433.1
    LOCUS AAA58433 604 aa linear PRI 31-DEC-1994 DEFINITION cyclooxygenase-2 [Homo sapiens]. ACCESSION AAA58433 VERSION AAA58433.1 GI:181254 DBSOURCE locus HUMCYCLOX accession M90100.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 604) AUTHORS Hla,T. and Neilson,K. TITLE Human cyclooxygenase-2 cDNA JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (16), 7384-7388 (1992) PUBMED 1380156 COMMENT Method: conceptual translation. FEATURES Location/Qualifiers source 1..604 /organism="Homo sapiens" /db_xref="taxon:9606" /cell_type="endothelial" /tissue_type="umbilical vein" Protein 1..604 /product="cyclooxygenase-2" /EC_number="1.14.99.1" sig_peptide 1..17 /gene="Cox-2" mat_peptide 18..604 /gene="Cox-2" /product="cyclooxygenase-2" /EC_number="1.14.99.1" Region 19..54 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their

    biological function and calcium-binding sites have been found to be located at the...; cd00054" /db_xref="CDD:28936" order(20,34) /site_type="other" /note="Ca2+ binding site [ion binding]" /db_xref="CDD:28936" 75..562

    Site

    Region

    /region_name="prostaglandin_endoperoxide_synthase" /note="Animal prostaglandin endoperoxide synthase and related bacterial proteins; cd09816" /db_xref="CDD:188648" Site order(103,191,331,334..335,339,341,367,371,373,504,508, 512..513,516..517,520) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:188648" Site order(111,113..115,122..126,128,215,305..309,312..313,316, 319..320,323,353..360,523..524,527..531,533..535,537..538) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:188648" Site order(134,185,189,193,196..198,281,368,371..374,377,394, 430,432..433,436) /site_type="other" /note="heme binding site [chemical binding]" /db_xref="CDD:188648" CDS 1..604 /gene="Cox-2" /coded_by="M90100.1:98..1912" ORIGIN 1 mlaralllca vlalshtanp ccshpcqnrg vcmsvgfdqy kcdctrtgfy gencstpefl 61 triklflkpt pntvhyilth fkgfwnvvnn ipflrnaims yvltsrshli dspptynady 121 gyksweafsn lsyytralpp vpddcptplg vkgkkqlpds neivgklllr rkfipdpqgs 181 nmmfaffaqh fthqffktdh krgpaftngl ghgvdlnhiy getlarqrkl rlfkdgkmky

    241 qiidgemypp wlrehnrvcd 301 vlkqehpewg llfnkqfqyq 361 nriaaefntl sftrqiagrv 421 aggrnvppav kemsaeleal 481 ygdidavely wkpstfggev 541 gfqiintasi inptvllker 601 stel

    tvkdtqaemi yppqvpehlr favgqevfgl vpglmmyati deqlfqtsrl iligetikiv iedyvqhlsg yhfklkfdpe yhwhpllpdt fqihdqkyny qqfiynnsil lehgitqfve qkvsqasidq srqmkyqsfn eyrkrfmlkp yesfeeltge pallvekprp daifgetmve vgapfslkgl mgnvicspay qslicnnvkg cpftsfsvpd peliktvtin asssrsgldd

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