15 Organic Synthesis
15 Organic Synthesis
15 Organic Synthesis
Daley
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Organic Chemistry
Chapter 15
Organic Synthesis
15.1 Synthesis Design and Strategy 771 15.2 Principles of Retrosynthetic Analysis 774 15.3 Protecting Groups 778 Synthesis of the Ethylene Glycol Acetal of Cyclohexanone 781 15.4 Lithium Dialkylcuprate Reagents 781 Synthesis of trans-Stilbene 784 15.5 A Synthetic Example 786 15.6 Synthesis of Difunctional Compounds 790 Key Ideas from Chapter 15 795
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Copyright 1996-2005 by Richard F. Daley & Sally J. Daley All Rights Reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the copyright holder.
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Chapter 15
Organic Synthesis
Chapter Outline
15.1 15.2 15.3 15.4 15.5 15.6 Synthesis Design and Strategy
An introduction to the logic of organic synthesis
Protecting groups
Learn the use of protecting groups
Synthetic Example
Applying the principles of retrosynthetic analysis to an actual synthesis
Objectives
Understand the principles of retrosynthetic analysis and be able to apply these principles to an organic synthesis Learn the use of a protecting group in organic synthesis Know how a lithium dialkylcuprate reagent reacts
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Its a strange sort of memory that only works backwards, said the Queen. Lewis Carroll
Retrosynthetic analysis is working from the desired product back towards some readily available starting material.
oing organic synthesis is the real test of your ability to use the reactions of organic chemistry. Chapters 7, 8, 12, 13, and 14 present many important organic reactions. Each chapter covers one mechanistic type. The chapter includes the rationale and scope of that particular bond-breaking and/or bond-forming reaction type, as well as several specific example reactions. Most examples are one-step reactions. With these one-step reactions, you can begin learning to do organic synthesis. Organic synthesis involves the conversion of a substrate to the desired product molecule. To make the product molecule, most organic syntheses require the use of a series of one-step reactions. Determining which reactions to use follows a technique called retrosynthetic analysis. E. J. Corey developed retrosynthetic analysis, and for this technique, along with some related research, he was awarded the Nobel Prize in 1990. Organic chemists use synthesis for a variety of purposes. Traditionally, a synthesis was the final proof of the structure of a natural product isolated from a plant or animal source. The necessity of using synthesis to prove the structure of a compound diminished after the advent of the instrumental methods of analysis, although chemists still commonly synthesize natural products. The synthesis of these natural products increases the available supply of the compounds for further study or use. Chemists also use synthesis to attempt to prepare previously unknown compounds that they predict to be useful either for testing chemical theories or for creating new products. Organic synthesis impacts every aspect of your life. For example, organic chemists design and produce most new pharmaceuticals. Often they start by using sophisticated computer software to predict what molecules might be the most active against a particular disease. Then they synthesize those molecules. Next, biochemists and/or biologists screen them for their activity in living organisms, and eventually physicians administer trials to human subjects. Another example is the high-performance polymers that affect our lives in so many ways. Everything from automobile parts to most modern sporting gear had their origins in organic synthesis.
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When designing the synthesis of a target molecule, you must consider the simplicity of the synthesis, the availability of potential starting materials, the product yield, the economics of the synthesis, and safety. In many respects the methods for designing a synthesis are similar to the methods used to solve puzzles. Both may have many possible pathways to follow in traveling from the starting point to the desired end. Some of these pathways are productive in reaching that end; others are not. Exercise 15.1 The yields of the individual steps in a multistep synthesis are important in the overall yield of the synthesis. Assume that you are carrying out a three-step synthesis. Calculate the overall yield of the synthesis if the individual yields are 84%, 87%, and 79%. Calculate the overall yield if the individual yields are 91%, 44%, and 88%. To develop a synthetic pathway for a particular compound, analyze the target molecule looking for a probable starting material. Because the concepts of mechanism and synthesis are inextricably blended in modern organic chemistry, follow much the same thought process that you use when trying to determine what mechanism a reaction follows. The more confident you feel about one, the better you will become at working with the other. The relationship between the probable substrate and the product involves two things: interconversion of the functional groups and changes in the carbon skeleton. These two factors also play an important part in the synthetic sequence that you use to prepare the product. Most of the reactions discussed to this point are functional group interconversions. That is, the reaction converts from one functional group to another. Only a few change or expand the carbon skeleton. To determine whether the reaction interconverts functional groups or changes the carbon skeleton, compare the number of carbons in both the target molecule and the potential starting material. If both molecules have the same number of carbon atoms, then it is likely that you can accomplish the synthesis by one or more functional group conversions. If they are of different sizes, then you must modify the skeleton. To modify the carbon skeleton, look for a substrate that allows you to add the simplest possible carboncontaining fragments to obtain the product. In most cases, expanding the number of carbons in the skeleton is easier than reducing the number of carbons.
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After determining whether or not the carbon skeleton changes, decide what you need to do to obtain the functional groups of the target molecule. Almost all syntheses involve the interconversion of at least one functional group to another. You must incorporate these interconversions into your synthesis strategy. Remember that most bonds break or form at or near the functional groups. A functional group is the active or activating portion of the molecule and thus plays a key role in the synthesis design. The key to the design of most organic syntheses is the functional groups in the target molecule. Exercise 15.2 Review all the various chemical reactions presented in the book to this point. Review Reaction Summary I and look ahead to Reaction Summary II. Analyze each reaction and indicate whether it interconverts one functional group to another, modifies the carbon skeleton, or both. After determining what carbon skeleton and functional group changes are needed, you are ready to develop the synthetic sequence. If you need to change the size of the substrate, plan to sequentially add portions to a single starting material. You may need to alter or rearrange the structure of the starting material. You may even need to follow a pathway that requires two or more simultaneous syntheses to obtain the necessary fragments to join together for the target molecule. Consider the development of the synthesis of 2-ethyl-2methylbutanoic acid from 2-butanone following the above process.
O CH3CH2CCH3 COOH CH3CH2CCH2CH3 CH3 2-Butanone 2-Ethyl-2-methylbutanoic acid
Reaction Summary I begins on page 000. Reaction Summary II begins on page 000.
Decide if the reaction requires any changes to the carbon skeleton. 2Butanone has four carbons; 2-ethyl-2-methylbutanoic acid has seven. Therefore, the synthesis must add three carbons. The easiest way to do this is to add an ethyl group and a carboxylic acid group to the carbon skeleton of the starting material.
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O CH3CH2CCH3
Of the various concepts you know at the present, the best synthetic method for this synthesis is the reaction of a Grignard reagent, or an organolithium compound, with a ketone.
O CH3CH2CCH3 1) CH3CH2MgBr 2) H3O OH CH3CH2CCH2CH3 CH3
This step accomplishes the synthesis of the carbon skeleton for the target molecule leaving you with one or more functional group conversions to complete the synthesis. All the various synthetic methods you have seen for the formation of a carboxylic acid begin with an alkyl halide except for the chromate oxidation of an alcohol. An alcohol easily converts to a halide, so the remaining portion of the synthesis is alcohol halide carboxylic acid.
OH CH3CH2CCH2CH3 CH3 HBr Br COOH 1) Mg/ether 2) CO2 3) H3O CH3CH2CCH2CH3 CH3
CH3CH2CCH2CH3 CH3
Of course, you can vary the details of each of these steps with any of the different reagents that you have studied earlier. An important principle in laboratory organic synthesis is the same carbons that bear functional groups in the target compound often bear groups in the starting materials or intermediates in a synthesis. Numerous reactions remove a functional group from a carbon atom or exchange one functional group for another, but very few reactions introduce a functional group onto a carbon of a hydrocarbon. Often the location of a functional group in a starting material is more important than its actual structure. An existing functional group can usually be converted to the desired functional group. Exercise 15.3
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Devise a synthesis for each of the following compounds from methanol as your only source of organic carbon and any required inorganic compounds. a) Dimethyl ether c) 2-Bromopropane Sample solution a)
CH3OH HBr CH3Br CH3O CH3OCH3
Retrosynthetic analysis involves dissecting the target molecule to determine a potential precursor for each part while working to keep all the parts fitting together.
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compounds with one functional group and possibly one additional alkyl substituent. Four-membered rings and rings larger than eight atoms are hard to find. Biochemical sources provide many complex biochemical molecules and many chiral molecules. In the syntheses of complex molecules, chemists usually start with molecules containing six carbons or less, as the more complex substrates are seldom readily available. The following synthesis example of 4-bromoheptane uses only commercially available starting materials containing four or fewer carbons. This example also demonstrates retrosynthetic analysis to determine the synthetic pathway.
Br CH3CH2CH2CHCH2CH2CH3 4-Bromoheptane
Many of the reactions discussed so far in this book that synthesize alkyl halides, begin with an alcohol. Therefore, this synthesis is really a synthesis of the corresponding alcohol, 4-heptanol.
OH CH3CH2CH2CHCH2CH2CH3 4-Heptanol P, Br2 Br CH3CH2CH2CHCH2CH2CH3
Sections 7.8 and 8.6 give two possible pathways for the synthesis of the alcohol. One pathway begins with butanal; the other begins with methyl formate. Both substrates react with propylmagnesium bromide, a Grignard reagent. Grignard reactions and alkyl lithium reactions involving a carbonyl group are the only methods presented so far that produce alcohols at the same time that they build the carbon skeleton. The following pathway also works with the propyllithium reagent:
O CH3CH2CH2CH O HCOCH3 CH3CH2CH2MgBr H3O OH CH3CH2CH2CHCH2CH2CH3
Either pathway is a viable choice. The one you choose depends on the availability of reagents. You could easily synthesize the Grignard
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The technique of retrosynthesis allows you to propose an extended synthesis much more easily than proposing a synthesis from starting materials and working toward the product. Although working backwards in a synthesis may seem clumsy at first, chemists prefer this method for dealing with synthesis. Practice retrosynthesis with all the appropriate exercises in this, and subsequent, chapters. Exercise 15.4 Propose a synthesis of 1-phenyl-2-butanone from phenylacetonitrile. Show all the steps in your analysis of the synthetic sequence.
O CH2C N CH3CH2CCH2
Phenylacetonitrile
1-Phenyl-2-butanone
The design of the synthesis of methylenecyclohexane from cyclohexene expands on the principles discussed above. CH2
Methylenecyclohexane
Begin the synthesis at the carbon skeleton. Rings are often best used as starting materials, so begin with a six-membered ring substrate. The proposed synthesis looks like this.
X + CH3 Y CH2
The above synthesis sketch represents the retrosynthetic analysis of the entire synthesis. Next comes the development of the steps of how
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to do the actual synthesis. These steps break down into three smaller retrosynthetic analyses and the detailed synthetic steps of each. You can easily produce the double bond by using the Wittig reaction on the cyclohexanone substrate. O
Ph3P CH2
CH2
Cyclohexanone becomes the new target. The synthesis for cyclohexanone is an oxidation of cyclohexanol. Either oxymercuration or hydroboration of cyclohexene accomplishes the synthesis of cyclohexanol.
OH 1) BH3, THF 2) H2O2, OH KMnO4, OH H2O
Exercise 15.5 Propose a synthesis for each of the following compounds starting from monofunctional organic compounds of three or fewer carbons as well as monofunctional rings of up to six carbons. a)
CH3CH2CH2CH2CH2OH
b)
Cl CH3CH2CCH2CH2CH3 CH3
c)
CH C(CH3)2
d)
OH C(CH2CH3)2
Sample solution a) This product is readily made from the reaction of a Grignard reagent with ethylene oxide.
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3) H3O
A protecting group temporarily transforms one reactive functional group to another functional group that is unreactive with a particular set of reaction conditions.
HOCH2CH2OH
H H3O
O R
O R
Acetal formation/hydrolysis
R C R C
R R
Br2 KI
R R C
Br C R
Br R
Both reactions qualify as protecting reactions because both change the functional group, an aldehyde or ketone in the first reaction and a double bond in the second, to a different functional group with a different reactivity. In both cases, the original functional group is
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readily regenerated after you no longer need the protecting group. This ease of regeneration is very important as it allows you to return the protecting group back to the original functional group. The following example shows the use of a protecting group in the reaction of a keto acid to form a diketone.
O O
COH O
CCH2CH2CH3 O
Reacting the carboxylic acid functional group with propyl lithium easily transforms it to the ketone.
R COH O 1) CH3CH2CH2Li 2) H3O R CCH2CH2CH3 O
However, the propyllithium would also react with the ketone to form an alcohol. Thus, instead of a diketone, you would get the following product.
O HO 1) CH3CH2CH2Li COH O 2) H3O CCH2CH2CH3 O CH2CH2CH3
The plan is to protect the ketone functional group, by reacting it with ethylene glycol to form the acetal group, then to react the carboxylic acid with propyllithium, and finally to add acid to regenerate the ketone. The following illustration shows the complete synthetic scheme.
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O HOCH2CH2OH COH O H
CCH2CH2CH3 O
CCH2CH2CH3 O
Organic chemists have many, many protecting groups that they use. Table 15.1 lists five common ones that relate to the reaction types that you have studied thus far. All protecting groups have two common properties: they decrease the reactivity of the substrate towards a particular reagent, and they regenerate the original functional group easily, after the completion of the desired reaction. Group to be protected.
O R' OH
Reagents
Protected group
ROH and H
R'
O OR
O R
O R C R
O R
Acetal
R OH
(CH3)3SiCl, pyridine
H , O
O Si ( C H 3 ) 3
H3O or Fc H3O
Trimethylsilyl ether
OH
RO
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Group to be protected.
R C R C R R
Reagents
Protected group
R Br C R R
Br2
C Br
Note that reactivity of the protected group determines the choice of what protecting group to use. For example an acetal is stable in alkaline reactions, but aqueous acid rapidly hydrolyzes the acetal. Or trimethylsilyl ethers are stable only under anhydrous conditions.
Exercise 15.6 Chemists consider ethers to be chemically inert, but the tetrahydropyranyl ether that chemists use to protect the alcohol is quite easy to remove. Explain.
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For the organometallic synthesis of alcohols and ketones see Sections 7.7, page 000, and 8.6, page 000. A lithium dialkylcuprate reagent has the formula R2CuLi.
Earlier discussions of the synthesis of alcohols and ketones presented numerous synthetic methods that use organometallic compounds. Another very versatile organometallic reagent to add to that list is the lithium dialkylcuprate reagent. The lithium dialkylcuprate reagent is called the Corey-House reagent in honor of its inventors, E. J. Corey (Harvard University) and Herbert O. House (Georgia Institute of Technology). The Corey-House reagent is synthesized by the reaction of one mole of copper(I) iodide (CuI) with two moles of an alkyl lithium compound (RLi). The empirical formula of the Corey-House reagent is R2CuLi.
RLi CuI R2CuLi
The lithium dialkylcuprate reagent is widely used in reactions with alkyl halides to produce alkanes and with acyl halides to produce ketones.
R'
O R' C X
R2CuLi
R'
R
O
R2CuLi
R'
A coupling reaction is one where two reactants join together. This joining is usually via a CC bond.
- ) is present as The general reaction takes place as if a carbanion (R:c the nucleophile in an SN2 or nucleophilic carbonyl substitution reaction. However, the mechanism of reactions involving the lithium dialkylcuprate reagent is not well understood. A problem with the lithium dialkylcuprate reagent is that only one of the alkyl groups is used. The other becomes a copper(I) alkyl. Thus, when considering the use of an alkyl group with the cuprate reagent, you must think about the expense and difficulty of obtaining the cuprate reagent. Coupling a lithium dialkylcuprate reagent with an alkyl halide normally produces excellent yields of alkanes. The alkyl groups of the halide can be methyl, primary, or secondary cycloalkyl halides, as would be expected from an SN2 reaction. Acyclic secondary alkyl halides and all tertiary alkyl halides are too sterically crowded to react in an SN2 reaction. The group in the lithium dialkylcuprate generally is methyl, primary, or secondary. Tertiary alkyl halides are too crowded for the lithium dialkylcuprate reagent to form. In the following examples, the lithium dialkylcuprate reagent acts as a - nucleophile in an S 2 reaction. source of R:c N
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CH3CH2CH2CH2Br
(CH3CH2CH2)2CuLi
CH2CH2CH3
Br
(CH3)2CuLi
CH3
Methylcyclohexane (77%)
Lithium dialkylcuprates also react with vinyl and phenyl halides, both of which are very unreactive to nucleophilic attack. These reactions do not occur with an SN2 mechanism.
CH3CH2CH2CH2CH2 C H H C I CH3CH2CH2CH2CH2 C H E-5-Undecene (78%) C CH2CH2CH2CH3 H (CH3CH2CH2CH2)2CuLi
(CH3CH2CH2)2CuLi
CH2CH2CH3
Propylbenzene (78%)
The formation of ketones via reaction of the lithium dialkylcuprate with an acyl halide generally produces good yields of product. This reaction is limited to the use of methyl, primary alkyl, and aryl cuprates.
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O CCH3
Acetophenone (58%)
O CCl (CH3)2CuLi -78oC, ether O CCH3
Synthesis of trans-Stilbene
Br
Li CuBr 2
CuLi
trans-Stilbene (90%)
Lithium diphenylcuprate Place 728 mg (5.1 mmol) of CuBr in a dry 100 mL round-bottom flask. Add a stirbar and place a rubber septum on the flask. Attach a tube to a nitrogen source and another tube to a bubbler to monitor the flow of nitrogen. Place the flask in an ice bath. Flush the flask with nitrogen for 5-10 minutes while the flask and its contents are cooling. Stop the flow of nitrogen and add 15 mL of anhydrous ethyl ether to the flask. Rapidly stir the suspension of CuBr in the ether. Slowly add 5.5 mL (10 mmol) of ice-cold 1.8 M phenyllithium solution. After 10-15 minutes, most of the suspended solid should disappear and the slightly cloudy solution has become pale yellow or greenish yellow. Keep this solution cold and use as soon as possible. trans-Stilbene
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Dissolve 365 mg (2 mmol) of trans--bromostyrene in 8 mL of anhydrous ethyl ether. Add this solution to the lithium diphenylcuprate solution previously prepared. Remove the ice bath. Stir the reaction mixture under a nitrogen atmosphere for 4 hours at room temperature. During this time a yellow green precipitate slowly separates. Prepare 15 mL of a solution of saturated aqueous NH4Cl adjusted to pH 9 by adding concentrated ammonia solution. Separate the layers formed. Extract the aqueous layer with two 5 mL portions of ether. Wash the combined ether solutions with 10 mL of saturated aqueous sodium chloride. Dry the ether layer with anhydrous sodium sulfate and evaporate the ether on a rotary evaporator. The residue is nearly pure trans-stilbene. The yield is 306 mg (90%), m.p. 119-123oC. Discussion Questions 1. When making the lithium diphenylcuprate, why do you stop the nitrogen flow before adding the ether to the CuBr? 2. What is the yellow green precipitate that forms during the reaction? Look for the solubility of that compound in a chemical handbook. Is the compound soluble or insoluble in ether?
Exercise 15.7 Predict the major products for each of the following reactions. a)
I (CH3CH CHCH2)2CuLi
b)
Br (CH3CH2)2CuLi
c)
O Cl CH3 (CH3CHCH2)2CuLi -78o, ether
Sample Solution b)
Br (CH3CH2)2CuLi CH2CH3
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Pheromones are compounds that animals and insects use to communicate information to each other.
The gypsy-moth sex attractant pheromone is readily synthesized using the principles and techniques presented to this point. The compound is monofunctional with an epoxide group. The two saturated alkyl chains attached to the ring are cis to one another. One of the alkyl groups contains one branch, a methyl group. When planning the synthetic pathway, place the synthesis of the epoxide ring as the last step because the epoxide is quite reactive. Synthesizing the epoxide can follow either of two methods, both of which involve additions to a double bond. One method reacts bromine in water with the alkene. The resulting bromohydrin is reacted with a base. The other method is a peracid oxidation.
Br2, H2O OH C Br C OH O RCO3H
Epoxide
Both reactions retain the configuration of the alkene substrate. Either method works well for the formation of an epoxide. Generally, though, chemists choose the peracid oxidation, because it is simpler and usually gives a higher yield of product. The next step backward in the retrosynthetic analysis is the synthesis of cis-2-methyl-7-octadecene.
cis-2-Methyl-7-octadecene
Here again there are several methods available to consider for the synthesis of this compound. For example, you might dehydrate or
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dehydrohalogenate the appropriate alcohol or alkyl halide. Unfortunately, neither method gives the double bond only in the desired position and neither one clearly gives only the cis double bond. In fact, either reaction usually gives a higher yield of the more stable trans double bond. This approach leads to a dead end. A second method for the formation of a double bond is the Wittig reaction. The reaction of the phosphorus ylide with a carbonyl group is regiospecific but gives a mixture of both cis and trans isomers. This is another dead end. A third method for the formation of a double bond is the catalytic hydrogenation of an alkyne using a Lindlar catalyst. This reaction is both regiospecific and stereospecific. Thus, it gives the double bond in the correct position with only the cis isomer.
The alkyne is constructed from 1-dodecyne, which is commercially available, and 1-bromo-5-methylhexane, which is not readily available and will need to be synthesized.
NaNH2 Br
The synthesis is nearly complete. All that remains is to prepare 1-bromo-5-methylhexane. A halogen compound is generally prepared from an alcohol.
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OH
PBr3
Br
There are several ways to synthesize a primary alcohol. These include the reduction of an aldehyde, carboxylic acid, or ester; the addition of water by hydroboration or oxymercuration-demercuration; and a Grignard reaction with formaldehyde or an epoxide. The carbon skeleton has seven carbons making it unlikely that the required aldehyde, acid, ester, or alkene is readily commercially available. Thus, the Grignard reaction, which involves the construction of the skeleton from smaller fragments, is the best choice. Recall from Chapter 7 that the reaction of a Grignard reagent with formaldehyde is a method that extends the length of a chain by one carbon.
O RMgBr 1) HCH 2) H3O RCH2OH
Recall from Chapter 12 that the reaction of a Grignard reagent with an epoxide extends the chain by two carbons.
1) O RCH2CH2OH
RMgBr
2) H3O
The choice between these two Grignard reactions depends on the availability of the starting materials. Either reaction is a viable method. Usually you can get monofunctional molecules with either five or six carbons, so this gives you two alternate syntheses for 1bromo-5-methylhexane.
O CH3CHCH2CH2CH2MgBr CH3 1) HCH 2) H3O CH3CHCH2CH2CH2CH2OH CH3
1) CH3CHCH2CH2MgBr CH3
O CH3CHCH2CH2CH2CH2OH CH3
2) H3O
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Of these two syntheses, the second is preferred because the bromide for the Grignard reagent synthesis is more readily available. Figure 15.1 shows the complete synthesis for the Gypsy-moth sex attractant.
1) O OH
Br
Mg ether
2) H3O PBr3 Br
NaNH2 Br
H2
Pd/BaSO4 Quinoline
CF3CO3H O
Exercise 15.8 Propose a synthesis for the following compounds starting with any monofunctional, unbranched organic molecules containing six or fewer carbons that are likely to be readily available. In addition, you may use any required inorganic reagents or specialized organic reagents necessary to complete the reaction.
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a)
CH2CH2NH2
b)
OH
c)
CH3 OCH3
d)
Cl Cl
Sample solution a)
Br 1) Mg, ether 2) O CH2CH2OH
O NH O
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OH OH
5-Ethyl-6-methyl-1,6-heptanediol
5-Ethyl-6-methyl-1,6-heptanediol contains two alcohol functional groups: one primary and the other tertiary. The carbon skeleton contains one methyl and one ethyl branch. There are two basic methods for the synthesis of a primary alcohol: a Grignard synthesis and a hydroboration.
OH Br
1) Mg O 2) OH OH
3) H3O 1) BH3
OH
2) H2O2, OH
Because a Grignard reagent does not form in the presence of an acidic hydrogen, you must protect the tertiary alcohol when using a Grignard reaction. (Note: Trying to perform a Grignard reaction on one part of a molecule in the presence of an acidic functional group elsewhere in the molecule is a common error made by many beginning organic chemists.) The second reaction, hydroboration, can work in the presence of an alcohol. However, hydroboration requires an excess of reagent because the alcohol hydrogen reacts with the hydride from borane to produce hydrogen gas. But, borane is inexpensive enough to make protection of the alcohol unnecessary; thus, hydroboration is the preferred approach. The synthesis of the tertiary alcohol has three possible approaches. Two are Grignard reactions, and the third is a solvolysis of an alkyl halide. The solvolysis reaction is not very practical because the alkyl halide substrate needed for the solvolysis reaction is most easily made from the alcohol you want to produce. Both Grignard reactions are viable possibilities, and both produce the tertiary alcohol in a good yield.
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O 1) CH3BrMg 2) H3O OH
1) Mg Br
O 2) CH3CCH3 3) H3O
To use the first Grignard reaction, you must make the ketone. You know of two syntheses for ketone preparation. The first is a reaction of a Grignard reagent with a nitrile. The second is the reaction of an alkyllithium reagent with a carboxylic acid. Note, however, that both of those syntheses begin with 5-bromo-1-heptene, which is the same alkyl halide as the second Grignard pathway shown above. Therefore, it makes good sense to save a step in the synthesis and avoid the ketone altogether.
1) Mg Br or 1) Li O 2) CH3COH 3) H3O 2) CH3C 3) H3O N O
5-Bromo-1-heptene is not generally commercially available, but you can readily synthesize it from commonly available reagents. Use a Grignard reagent on an epoxide to produce an alcohol with the OH group on the correct carbon. Then replace this OH group with bromine by using PBr3 as a reagent.
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Br
Mg
MgBr 1) 2) H3O
Br
PBr3
HO
1) 2) H3O Br PBr3 HO
1) Mg
Exercise 15.9 Propose a synthesis for the following compounds starting with any monofunctional unbranched organic molecules likely to be readily available as well as any required inorganic reagents or specialized organic reagents.
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a)
Cl Cl N(CH3)2
b)
Sample Solution a)
CH3I N H (excess) H3C N I CH3 Ag2O, H2O N H3C CH3 OH
Cl
(CH3)3CO , DMSO
Selectivity allows a reaction to proceed with one functional group in preference to another.
Recall from Section 15.3 that chemists deal with two functional groups either by turning one into a protecting group until they complete their reaction on the other functional group, or by controlling the reaction conditions. Another approach for using one functional group in a reaction but not the other is through selectivity. By applying the principles of selectivity you can make a change at one functional group but leave the other unchanged. Because of selectivity, one equivalent of reagent reacts almost completely with one functional group and very little with the other. Certain types of reactions provide selectivity, as do certain types of substrate structures. The following list summarizes how selectivity works in different types of related reactions. 1. The order of reactivity for carbonyl-containing functional groups toward a nucleophile is acyl halide > aldehyde > ketone > ester > nitrile > amide > carboxylate anion. 2. The reactivity difference between primary, secondary, and tertiary carbon atoms toward a nucleophilic substitution is sufficient to provide adequate selectivity. 3. Esterification of alcohols follows the sequence of primary > secondary >> tertiary. Tertiary alcohols are quite unreactive towards ordinary esterification techniques. 4. A reaction that forms a five- or six-membered ring is usually significantly faster than an intermolecular reaction. It also has a higher equilibrium constant.
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Organic Chemistry - Ch 15
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5. Sodium borohydride reacts with acyl halides, aldehydes, and ketones. Lithium aluminum hydride reduces those substrates as well as the remaining members of the carboxylic acid family. 6. Carboncarbon double bonds are not reactive towards nucleophiles unless conjugated with electron-withdrawing groups (more in Chapter 16). 7. The rate for catalytic hydrogenation is triple bond > double bond > carbonyl >> aromatic ring. A modified catalyst reduces a triple bond in the presence of a double bond.
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5 July 2005
Organic Chemistry - Ch 15
797
When doing a reaction on a substrate containing multiple functional groups, analyze the selectivity of the possible reactants. If a particular reactant will affect the functional groups other than the one where the reaction is to take place, use a protecting group or a different reagent.
www.ochem4free.com
5 July 2005