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Minnesota Department of Health

Directly Observed Therapy (DOT) for the Treatment of Tuberculosis


For Health Care Professionals
National TB treatment guidelines strongly recommend using a patient-centered case management approach - including directly observed therapy (DOT) - when treating persons with active TB disease. DOT is especially critical for patients with drug-resistant TB, HIV-infected patients, and those on intermittent treatment regimens (i.e., 2 or 3 times weekly). What is DOT? DOT means that a trained health care worker or other designated individual (excluding a family member) provides the prescribed TB drugs and watches the patient swallow every dose. Why use DOT? We cannot predict who will take medications as directed, and who will not. People from all social classes, educational backgrounds, ages, genders, and ethnicities can have problems taking medications correctly. Studies show that 86-90% of patients receiving DOT complete therapy, compared to 61% for those on self-administered therapy. DOT helps patients finish TB therapy as quickly as possible, without unnecessary gaps. DOT helps prevent TB from spreading to others. DOT decreases the risk of drug-resistance resulting from erratic or incomplete treatment. DOT decreases the chances of treatment failure and relapse. Who can deliver DOT? A nurse or supervised outreach worker from the patients county public health department normally provides DOT. In some situations, it works best for clinics, home care agencies, correctional facilities, treatment centers, schools, employers, and other facilities to provide DOT, under the guidance of the local health department. Family members should not be used for DOT. DOT providers must remain objective.
Tuberculosis (TB) Prevention and Control Program P.O. Box 64975 St. Paul, MN 55164-0975 651-201-5414, 877-676-5414 www.health.state.mn.us/tb

For complex regimens including IV/IM medications or twice daily dosing, home care agencies may provide DOT or share responsibilities with the local health department. If resources for providing DOT are limited, priority should be given to patients most at risk. See the MDH DOT Risk Assessment form for help identifying high-priority patients (www.health.state.mn.us/divs/idepc/diseases/tb/ dottool.html).

How is DOT administered? DOT includes: delivering the prescribed medication checking for side effects watching the patient swallow the medication documenting the visit answering questions notifying the physician if the patient has side effects, clinical problems or misses DOT visits. DOT should be initiated when TB treatment starts. Do not allow the patient to try selfadministering medications and missing doses before providing DOT. If the patient views DOT as a punitive measure, there is less chance of successfully completing therapy. The prescribing physician should show support for DOT by explaining to the patient that DOT is widely used and very effective. The DOT provider should reinforce this message. DOT works best when used with a patientcentered case management approach, including such things as: helping patients keep medical appointments providing ongoing patient education offering incentives and/or enablers connecting patients with social services or transportation Patients taking daily therapy can usually selfadminister their weekend doses.

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DOT for the Treatment of Tuberculosis page 2


How can a DOT provider build rapport and trust? 1. Start where the patient is. 2. Protect confidentiality. 3. Communicate clearly. 4. Avoid criticizing the patients behavior; respectfully offer helpful suggestions for change. 5. Be on time and be consistent. 6. Adopt and reflect a nonjudgmental attitude. For further information or assistance making referrals for DOT, contact the Minnesota Department of Health, TB Prevention and Control Program, (651) 201-5414.
References: 1.Treatment of Tuberculosis, American Thoracic Society, CDC and Infectious Diseases Society of America, Am J Respir Crit Care Med, Vol 167, 2003 (on line at: www.cdc.gov/mmwr/preview/mmwrhtml/rr5211a1.htm) 2. Interactive Core Curriculum on Tuberculosis (Webbased), CDC, 2004 www.cdc.gov/nchstp/tb/webcourses/corecurr/index.htm 3. DOT Essentials: A Training Curriculum for TB Control Programs, Francis J. Curry National Tuberculosis Center, 2003 4. Management: Directly Observed Therapy, New York City Department of Health, 2001.

MDH (1/06)

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