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Drug Dilantin

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NURS 1556 Clinical Medication Worksheet Karen Nielsen

Generic Trade Name Classification Dose Route Time/frequency


Name Antiarrhythmic
Phenytoin Dilantin (group IB), 100 mg PO QD
anticonvulsant
Peak Onset Duration For IV meds, compatibility with IV drips and /or solutions
1.5-3 hr 2-24 hr 6-12 hr N/A but of note: use of IV phenytoin in geriatric pt may
increase risk of serious adverse effects.
Mechanism of action and indications: Nursing Implications (what to focus on)
(Why med ordered) Contraindications/warnings/interactions-Hypersensitivity;
Sinus bradycardia, SA node block, 2nd or 3rd degree heart
Rx limits seizure propagation by altering ion transport, block. Caution in pt with severe cardiac or respiratory
may also decrease synaptic transmission. disease. Interacts with alcohol, gabapentin, omeprazole,
(may increase phenytoin drug levels). Antidepressants may
For Tic disorder. cause additive CNS depression.
Common side effects: CNS: ataxia, agitation, confusion,
drowsiness, dizziness, dysarthria, dyskinesia, extra
pyramidal syndrome, H/A, insomnia, weakness.EENT:
diplopia, nystagmus. CV: hypotension, tachycardia. GI:
gingival hyperplasia, N/V, constipation, drug-induced
hepatitis. Derm: hypertrichosis, rash, pruritis.
Hemat: Agranulocytosis, aplastic anemia, leukopenia,
megaloblastic anemia, thrombocytopenia. MS:
osteomalacia. Misc: allergic reactions including Stevens-
Johnson syndrome, fever, lymphadenopathy.
Interactions with other patient drugs, OTC or Lab value alterations caused by medicine:May increase
herbal medicines (ask patient specifically): serum alkaline phosphatase, GGT, and glucose levels.
Monitor serum folate concentrations periodically during
Gabapentin and omeprazole may increase drug levels. prolonged therapy.
The SSRI Zoloft may cause additive CNS depression
effects. Be sure to teach the patient the following about this
medication: Take with meals or right after to minimize GI
irritation. Chewable tablets must be crushed or chewed
well before swallowing. Take same time each day. May
cause drowsiness or dizziness. Maintain good oral hygiene.

Nursing Process- Assessment Assessment Evaluation


(Pre-administration assessment) Why would you hold or not give this Check after giving:
med?
Assess for phenytoin hypersensitivity Decrease in Tic disorder.
syndrome, (fever, skin rash, Signs of hypersensitivity, or Monitor serum phenytoin
lymphadenopathy). Vital signs. abnormally low heart rate, <50. levels routinely. Therapeutic
blood levels ( 10-20
mcg/ml).

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