www.dft.uem.

br/wsng
FINAL REPORT
We have successfully completed the Workshop: Neurogenesis: Basic aspects and
implications on neuropsychiatric conditions with enthusiastic discussions and
presentations by students, researchers and professors.
The Workshop: Neurogenesis: Basic aspects and implications on
neuropsychiatric conditions take place at the University of Maring in Maring,
Paran, Brazil, from 3rd to 5th August 2015.
We received about 49 applications as answers to the announcement of the Workshop
(please see list of participants). We had graduate students, post-graduate students,
researchers and professors from several Brazilian provinces such as: Rio de Janeiro,
Minas Gerais, So Paulo, Paran, Santa Catarina. From all applications, 25 participants
were selected to participate of the seminars that occurred in the afternoon period. The
selected candidates presented a very nice letter of interest focusing in their need to
better understanding the process of adult neurogenesis in order to include or to propose
some related experiments in their thesis or researchs projects.
After the opening of the Workshop with the presence of the Rector of our University Dr
Mauro Baeso, Dr Rbia Maria W. de Oliveira (State University of Maring, Brazil) spoke
about the basic aspects of adult neurogenesis. Her talk was followed by Dr Ismael
Galve-Roperh (Universidad Complutense, Madrid) and Dr Cilene Lino de Oliveira
(Federal University of Santa Catarina, Brazil), who introduced topics related to
neurogenic niches and adult neurogenesis regulation (please see the program below).
After lunch the participants had the opportunity of presenting their results in a poster
session (poster list below). The abstracts were published in the Anals of Workshop:
Neurogenesis: Basic aspects and implications on neuropsychiatric conditions, ISBN
978-85-66182-02-6. In the same day, the 25 selected students were divided in four (4)
groups for seminar presentations. Each group had an expert in the field of the seminar
to help them with the seminars.

Three participants (Taysa Bassani/Federal University of Paran, Lgia Mendes

Soares/State University of Maring and Victor Rodrigues Santos/University of So
Paulo) were selected accordingly their letters and research projects to present orally
their experimental results. The oral presentation occurred before the afternoon seminars
when very interesting and productive discussions taken place followed by the
consultancy of the experts in the area.
In the second day, Dr Alline C. Campos (University of So Paulo, Brazil) and Dr Lorena
Varela Nallar (Universidad Andres Belo, Chile) talked about neurogenesis and
neuropsychiatric conditions such as stress and Alzheimers disease. Dr Roberto
Andreatrini (Federal University of Paran, Brazil) followed their presentations giving us
a clinical and translational view of the experimental findings and the importance of the
neurogenesis in mania and depression. At night, local students prepared a very nice
party with folk music and typical Brazilian food.
In the last day, Dr Gabriel Arisi (Federal University of So Paulo, Brazil) highlighted the
morning with an interesting talk about methods of microscopy quantification focusing in
stereology and clarity.
After the seminars in the afternoon, we had a quick evaluation of the Workshop and the
participants ranked their global experience as positive an informative with clear cut
effects in their future scientific works. Please see in attach the pictures.

1. LECTURERS
Prof. Dr. Alline Cristina de Campos Medical School, Department of
Pharmacology, University of So Paulo, Ribeiro Preto, Brazil.
Prof. Dr. Cilene Lino de Oliveira Federal University of Santa Catarina,
Department of Physiology, SC, Brazil.
Prof Dr Gabriel Arisi Federal University of So Paulo, Laboratory of
Neurobiology, So Paulo, Brazil.
Prof Dr Ismael Galve-Roperh - Universidad Complutense de Madrid,
Departamento de Bioquimica y Biologia Molecular, Madri, Espanha.
Prof. Dr. Lorena Varela-NallarInvestigaciones, Santiago, Chile

Universidad

Andres

Belo,

Centro

de

Prof Dr Roberto Andreatini Federal University of Paran, Department of

Pharmacology, Curitiba, Paran, Brazil.

 Prof. Dr. Rbia Maria Weffort de Oliveira State University of Maring,

Department of Pharmacology and Therapeutics, Maring, Paran, Brazil.

2. PROGRAM AT A GLANCE

Workshop: Neurogenesis: basic aspects and implications

on neuropsychiatric conditions

03/08/2015

8:30-9:00 h

04/08/2015

05/08/2015

Rbia W. Oliveira

Alline Campos

Ismael G. Roperh

Neurogenesis: a
complex multi-step
process

Behavioral implication
of adult neurogenesis
during stress responses

Pharmacological
manipulation of adult
neurogenesis

Ismael G. Roperh

Lorena Varela-Nallar

Gabriel Arisi

Neural progenitor cells

in adult neurogenic
niches

Adult neurogenesis in
Alzheimers disease

Clarity and stereology

on quantitative analysis
of adult neurogenesis

Coffee break

Coffee break

Coffee break

Cilene L. Oliveira

Roberto Andreatini

Alline Campos

Environment influence
on adult neurogenesis

Implications of adult
neurogenesis in mood
disorders: focus on
mania

Would

Oppening

9:00-9:50 h

9:50-10:40 h

10:40-11:00 h

11:00- 11:50 h

12:00-13:30 h

Lunch

13:30-15:00 h

neurogenesis be a
possible target for the
treatment of
neuropsychiatric
disorders ?

Lunch

Lunch

Oral presentation (1)

Oral presentation (3)

Seminar 1

Seminar 3

In vitro and in vivo

In vitro and in vivo

Poster presentation
(29 posters)

3. LIST OF PARTICIPANTS (MORNING LECTURES AND POSTER

PRESENTATION)
1.
2.
3.
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49.

Amanda Nunes Santiago

Ana Paula Farias Waltrick
Anglica Pupin Schiavon
Betania Braga da Silva
Bruna de S Barbosa
Bruno Ambrsio da Rocha
Caio Cesar Sestile
Camila Fernanda Estevo da Silva
Cristiano Correia Bacarin
Ciomar Ap. Bersani Amado
Danielle Rodrigues de Souza
Debora de Mello Gonales SantAna
Emilene Dias Fiuza Ferreira
Erika Meyer
Fernanda Navarro Marin
Fernanda Troyner
Gabriel Gripp Fernandes
Gabriel Roldi Geraldo
Gabriela Travenolo
Gislaine Cardoso de Souza
Jacqueline Godinho
Humberto Milani
Jssica Mendes Bonato
Jessica Rosa
Jhonatan Christian Maraschin
Juliana dos Reis Bastos
Letcia Pin Coltri
Ligia dos Santos Mendes Lemes Soares
Lorena Gimenez da Silva
Luane Oliveira Reis
Lucas Gazarini
Manuela Torrado Truiti
Marco Aurlio Mori
Maria Aparecida Barbato Frazo Vital
Marina Aparecida Magnini Portes
Marina Masetto Antunes
Naielly Rodrigues da Silva
Natalia Yumi Batista Tamura
Nilson Carlos Ferreira Junior
Rafael Aguiar
Rafael Scoz Silva
Silvana Regina de Melo
Taketoshi Sakurada Junior
Taysa Bervian Bassani
Thais Emanoelle Tavares Pompeu
Tiago Guardia de Souza e Silva
Victor Rodrigues Santos
Vivian Suemi Batista Tamura
Vivian Taciany Bonassoli

PhD student
Graduation student
Researcher
Graduation student
Master student
PhD student
PhD student
PhD student
PhD student
Researcher/Professor
PhD student
Researcher/Professor
Researcher
Master student
Master student
Master student
Master student
Master student
Master student
Master student
PhD student
Researcher/Professor
Master student
PhD student
PhD student
Master student
Master student
PhD student
PhD student
Graduation student
Researcher
Graduation student
PhD student
Researcher/Professor
PhD student
Graduation student
Master student
Master student
Researcher
Master student
Master student
Researcher/Professor
Graduation student
PhD student
PhD student
PhD student
Researcher
Graduation student
Researcher

4. LIST OF
(AFTERNOON)

SELECTED

STUDENTS

FOR

THE

SEMINARS

1.Amanda Nunes Santiago

2.Bruno Ambrsio da Rocha
3.Caio Cesar Sestile
4.Cristiano Correia Bacarin
5.Emilene Dias Fiuza Ferreira
6.Erika Meyer
7.Fernanda Navarro Marin
8.Fernanda Troyner
9.Gabriel Gripp Fernandes
10.Jacqueline Godinho
11.Jssica Mendes Bonato
12.Jessica Rosa
13.Jhonatan Christian Maraschin
14.Juliana dos Reis Bastos
15.Ligia dos Santos Mendes Lemes Soares
16.Marco Aurlio Mori
17.Marina Aparecida Magnini Portes
18.Naielly Rodrigues da Silva
19.Nilson Carlos Ferreira Junior
20.Rafael Scoz Silva
21.Taysa Bervian Bassani
22.Thais Emanoelle Tavares Pompeu
23.Tiago Guardia de Souza e Silva
24.Victor Rodrigues Santos
25.Vivian Taciany Bonassoli

5. POSTERS PRESENTATIONS
1. HYPERGLYCEMIA IMPAIRS COGNITION IN MIDDLE-AGED RATS SUBJECTED TO CHRONIC
CEREBRAL HYPOPERFUSION. Amanda N. Santiago, Emilene D. F. Ferreira, Humberto Milani and
Rbia M. W. de Oliveira. State University of Maring, Department of Pharmacology and Therapeutics,
Maring, Paran, Brazil.
2. REPEATED CANNABIDIOL TREATMENT ENHANCES CELL PROLIFERATION AND
NEUROGENESIS IN THE HIPPOCAMPAL SUBGRANULAR ZONE AND SUBVENTRICULAR
ZONE. Schiavon AP1, Bonato JM1, Milani H1, Guimares FS2, de Oliveira RMMW 1. 1 Department of
Pharmacology and Therapeutics, State University of Maring, Paran. 2 Department of Pharmacology,
Medicine Faculty of Ribeiro Preto/So Paulo University
3. COMPARATIVE EFFECT OF CURCUMIN IN NATURA AND CURCUMIN NANOPARTICLE ON
EXPERIMENTAL INFLAMMATORY RESPONSE. Bruno Ambrsio da Rocha1, Edirlene Sara
Wisniewski Rebecca1, Odinei Hess Gonalves2, Fernanda Vitria Leimann2, Ciomar Aparecida
Bersani-Amado1. 1 Department of Pharmacology and Therapeutics, State University of Maring,
Maring-PR, Brazil. 2 Department of Food Technology, Federal Technological University of Paran,
Campo Mouro-PR, Brazil.
4. COOPERATION BETWEEN 5-HT1A AGONIST AND k-OPIOID ANTAGONIST: ANXIOLYTIC AND
PANICOLYTIC-LIKE EFFECTS IN ANIMAL MODELS. Caio Csar Sestile1, Marcel Pereira Rangel1,
Jhonatan Christian Maraschin1, Mariana Kitayama1, Camila Marroni Roncon2, Frederico Guilherme

5.

6.
7.

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15.

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Graeff2, Hlio Zangrossi JR2, Elisabeth Aparecida Audi1. 1 State University of Maring, Maring PR.
2 University of So Paulo, Ribeiro Preto SP.
MICROTUBULE-ASSOCIATED PROTEIN-2 (MAP2) EXPRESSION AFTER TRANSIENT, GLOBAL
CEREBRAL ISCHEMIA IN RATS AND THE INFLUENCE OF FISH OIL-TREATMENT. Cristiano
Correia Bacarin, Rbia Maria Weffort de Oliveira, Humberto Milani. Department of Pharmacology and
Therapeutics, State University of Maring, Maring-PR, Brazil.
Expression of glial cells and inflammatory cytokines after transient global cerebral ischemia:
Fish oil effects. Ferreira, E.D.F.; Romanini, C.V.; de Oliveira, R.M.M.W.; Milani, H. Department of
Pharmacology, State University of Maring, Paran, Brazil.
ANTIDEPRESSANT-LIKE EFFECTS OF MYRICITRIN AND ITS RELATIONSHIP TO ADULT
NEUROGENESIS IN MICE. Meyer E1, Mori MA1, Andreatini, R2, Milani H1, Oliveira RMW 1. 1
Department of Pharmacology and Therapeutics, State University of Maring, Paran. 2 Department of
Pharmacology, Federal University of Paran.
CHARACTERIZING/UNDERSTANDING THE FEAR GENERALIZATION PHENOMENON. Fernanda
Navarro Marin1, Leandro Jos Bertoglio1. 1. Department of Pharmacology. Federal University of Santa
Catarina, Biological Sciences Center, Florianopolis, Brazil.
THALAMIC NUCLEUS REUNIENS AND VENTRAL HIPPOCAMPUS: PROPOSED MODULATION
OF FEAR MEMORY SPECIFICITY. Fernanda Troyner1, Leandro Jos Bertoglio1. 1. Department of
Pharmacology. Federal University of Santa Catarina, Biological Sciences Center, Florianopolis, Brazil.
INVOLVEMENT OF THE DORSAL PERIAQUEDUCTAL GRAY IN THE CONTROL OF PANIC-LIKE
DEFENSIVE BEHAVIORS ELICITED BY HYPOXIA IN RATS. Gabriel G. Fernandes, Ailton Spiacci Jr,
Hlio Zangrossi Jr. School of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil.
CILOSTAZOL BUT NOT SILDENAFIL REVERTS CHRONIC CEREBRAL HYPOPERFUSIONINDUCED MEMORY DEFICIT IN RATS. Godinho, J; Bacarin CC; Ferreira, EDF; Zaghi, GGD; Oliveira,
JN; Oliveira, RMW, Milani, H. Department of Pharmacology and Therapeutics, State University of
Maring. Maring / PR.
Depressive-like behavior displayed by mice following cannabidiol withdrawal: preliminary
results. Jssica Mendes Bonato, Anglica Pupin Schiavon, Humberto Milani and Rbia M. Monteiro
Weffort de Oliveira. State University of Maring, Department of Pharmacology and Therapeutics,
Maring, Paran, Brazil.
THE EFFECT OF ACUTE STRESS AND THE ROLE OF MINERALOCORTICOID AND
GLUCOCORTICOID RECEPTORS PRESENT IN THE PREFRONTAL CORTEX IN THE MEMORY
EXTINCTION LEARNING. Jessica Rosa, Daniela Lescano Martins Uliana, Leandro Antero da Silva,
Leonardo Barbosa Moraes Resstel. Neuropharmacology Laboratory, Faculty of Medicine,
Pharmacology Department, University of So Paulo. Ribeiro Preto, So Paulo, Brazil.
INHIBITION OF OLIGOPEPTIDASES CAUSES PANICOLYTIC-LIKE EFFECT MEDIATED BY OPIOID RECEPTORS IN RATS. 1Jhonatan Christian Maraschin, 1Marcel Pereira Rangel, 1Antonio
Joaquim Bonfim, 1Mariana Kitayama, 2Frederico Guilherme Graeff, 2,3Hlio Zangrossi Jr., and
1,2
Elisabeth Aparecida Audi. 1. Department of Pharmacology and Therapeutic, State University of
Maring, Maring, Brazil. 2. Institute of Neurosciences and Behavior (INeC), Ribeiro Preto, Brazil. 3.
Department of Pharmacology, School of Medicine of Ribeiro Preto, University of So Paulo, Ribeiro
Preto, Brazil.
INHIBITION OF DOPAMINE TRANSPORTER INDUCES MANIA-LIKE BEHAVIOUR AND ALTERS
CYTOKINE LEVELS IN THE PREFRONTAL CORTEX AND HIPPOCAMPUS. Juliana R. Bastos1,2,4,
Aline S. Miranda3,4, Smia R. L. Joca5, Antnio L. Teixeira3,4, Fabrcio A. Moreira1,4. 1. Laboratory of
Neuropsychopharmacology, Department of Pharmacology, ICB; 2. Graduate Program in
Neuroscience; 3. Interdisciplinary Laboratory for Medical Research , FM; 4. Federal University of
Minas Gerais UFMG, BH, MG, Brazil. 5. School of Pharmaceutical Sciences of Ribeiro Preto,
University of So Paulo - USP.
CHRONIC ROLIPRAM TREATMENT INCREASES THE EXPRESSION OF NEURAL PLASTICITY
MARKERS IN MICE SUBJECTED TO BILATERAL COMMON CAROTID ARTERY OCCLUSION.
L.M. Soares1, Jochen De Vry2, J Prickaerts2, H Milani1 and R.M.W. de Oliveira1. 1. State University of

17.

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26.

27.

28.

Maring, Department of Pharmacology and Therapeutics, Maring, Paran, Brazil. 2. University of

Maastricht, Department of Psychiatry and Neuropsychology, Maastricht, Netherlands.
BRAIN LACTATE ALTERATIONS IN RATS SUBMITED TO FORCED SWIMMING. Patrcia Batista
Travassos1, Roberto Barbosa Bazotte1, Marina Masetto Antunes1, Vanessa Rodrigues Vilela1, Any de
Castro Ruiz Marques1, Tuane Krupek1, Lorena Gimenez da Silva1. 1. Department of Pharmacology
and Therapeutics, State University of Maring - UEM, Maring, Paran, Brazil.
OBJECT LOCATION MEMORY IMPAIRMENTS IN RATS SUBJECTED TO TRANSIENT GLOBAL
ISCHEMIA: EFFECTS OF FISH OIL. L.O. Reis, J.N. Oliveira, L.M. Soares, E.D.F. Ferreira, R.M.W.
Oliveira, H. Milani. Department of Pharmacology and Therapeutics, State University of Maring,
Maring, Paran, Brazil.
T. CATIGUA ETHYL ACETATE FRACTION PREVENTS ANXIETY-LIKE BEHAVIORS INDUCED BY
TRANSIENT BRAIN ISCHEMIA IN MICE. M. T. Truiti, J.P.C. Ferreira, L.M. Soares, Joo Carlos P.
Mello, Humberto Milani and R.M.W. de Oliveira. State University of Maring, Department of
Pharmacology and Therapeutics, Maring, Paran.
CANNABIDIOL AMELIORATES FUNCTIONAL OUTCOME AND INCREASES HIPPOCAMPAL
NEUROGENESIS IN ISCHEMIC MICE. M.A. Mori 1, E.Meyer1, L.M. Soares1, H Milani1, F. Guimares2
and R.M.W. de Oliveira1.1. State University of Maring, Department of Pharmacology and
Therapeutics, Maring, Paran, Brazil. 2. Faculty of Medicine of Ribeiro Preto, Ribeiro Preto, So
Paulo, Brazil.
STRENGTHENING AN AVERSIVE MEMORY: SYSTEMIC OR PRELIMBIC CORTEX ENHANCED
NORADRENERGIC ACTIVITY INDUCES GENERALIZED FEAR EXPRESSION. Marina Aparecida
Magnini Portes1; Ana Carolina Vanvossen 1; Lucas Gazarini 1; Karoline Batista Leite 1; Leandro Jos
Bertoglio 1. 1. Department of Pharmacology, CCB, Federal University of Santa Catarina, Florianopolis,
Brazil.
A COMPARARISON OF THE EFFECTS OF ORAL GLUCOSE AND LACTATE IN MICE SUBMITTED
TO INSULIN-INDUCED HYPOGLYCEMIA. Vanessa Rodrigues Vilela1, Roberto Barbosa Bazotte 1,
Lorena Gimenez da Silva1, Patrcia Batista Travassos1,Any de Castro Ruiz Marques1, Tuane Krupek1,
Marina Masetto Antunes1. 1. Department of Pharmacology and Therapeutics, State University of
Maring - UEM, Maring, Paran, Brazil.
EVALUATION OF THE EFFECTS INDUCED BY ACUTE AND REPEATED CANNABIDIOL
TREATMENT ON BEHAVIORAL CHANGES IN A MODEL OF SCHIZOPHRENIA BASED ON
ANTAGONISM OF NMDA RECEPTORS. Rodrigues, N.S.1; Silva, N.R1; Gomes, F.V1; Guimares,
F.S1. 1. Department of Pharmacology, Medical School of Ribeiro Preto, University of So Paulo,
Ribeiro Preto, Brazil.
ROLE OF DORSAL HIPPOCAMPUS ON BAROREFLEX ACTIVITY: INVOLVEMENT OF
GLUTAMATE/ ENDOCANNABINOIDS AND ACETYLCHOLINE/ NITRIC OXIDE PATHWAYS.
Ferreira-Junior NC, Lagatta DC, Resstel LBM. Department of Pharmacology, USP. Ribeirao Preto.
INFLUENCE OF CIRCADIAN RHYTHM ON THE EFFECTS OF CB1R ANTAGONISM ON THE
CONSOLIDATION OF CONTEXTUAL FEAR MEMORY. Scoz-Silva R, Gazarini L and Bertoglio LJ.
Department of Pharmacology, CCB, UFSC, Florianpolis, SC, Brazil.
COGNITIVE DECLINE IN THE STREPTOZOTOCIN-INDUCED MODEL OF ALZHEIMERS DISEASE
IS RELATED TO IMPAIRMENT IN HIPPOCAMPAL NEUROGENESIS. Taysa Bervian Bassani1, Meira
M. F. Machado1, Jssica M. Bonato2, Jacqueline Godinho2, Rbia M. W. Oliveira2 and Maria A. B. F.
Vital1. 1. Department of Pharmacology, Federal University of Paran, Curitiba PR, Brazil. 2.
Department of Pharmacology, State University of Maring, Maring, PR, Brazil.
EVALUATION OF THE MECHANISM OF ACTION OF LASSBio-579, AN ATYPICAL
ANTIPSYCHOTIC DRUG CANDIDATE AND ITS p-HIDROXYLATED METABOLITE: INVOLVEMENT
OF -arrestin2/Akt/GSK-3 PATHWAY THROUGH D2 RECEPTOR. Pompeu, Thais Emanoelle
Tavares1; Nol, Franois1. 1. Lab Farmacologia Bioqumica e Molecular, ICB, UFRJ.
EVALUATION OF NEUROPROTECTIVE AND BEHAVIORAL EFFECTS OF TREATMENT WITH
ROYAL JELLY ON ANIMAL MODEL OF SPORADIC ALZHEIMER'S DISEASE. Silva,TGS1;
Britto,LRG2; Xavier,GF3; Sandoval,MRL4. 1. Institute of Psychology, University of So Paulo, So
Paulo, Brazil. 2. Institute of Biomedical Sciences, University of So Paulo, So Paulo, Brazil. 3.

Institute of Biosciences, University of So Paulo, So Paulo, Brazil. 4. Pharmacology Laboratory,

Butantan Institute, So Paulo, Brazil.

29.

ABNORMAL MORPHOLOGICAL AND PHYSIOLOGICAL ALTERATIONS OF NEWBORN

NEURONS IN HIPPOCAMPUS IS CAPABLE OF CAUSING EPILEPSY. Victor R. Santos1,2; Raymund
Pun2; Candi LaSarge 2; Norberto Garcia-Cairasco1; Steve Danzer2. 1. Department of Physiology,
Ribeiro Preto Medical School, Ribeiro Preto SP, Brazil. 2. Department of Anesthesia, Cincinnati
Childrens Hospital Medical Center, Cincinnati OH, USA.

6. FINANTIAL SUPPORT
1)
2)
3)
4)
5)

Grants for national students (12 selected students x 150 Euros). 2.100 Euros
Grants for local students (12 selected students x 50 Euros) 550 Euros
Air tickets (faculties) ...... 200 Euros
Lunch and coffee breaks ... 400 Euros
Other expenses (transportation and photocopies) 250 Euros

TOTAL

3.500 Euros

7. SOME PICTURES OF THE WORKSHOP IN NEUROGENESIS

Openning ceremony with the presence of State University

of Maring Rector Dr Mauro Baeso and Health Science
Directors.

Lecture Dr Rbia Weffort de Oliveira: Neurogenesis: a complex multi-step

process

Lecture Dr Alline C. Campos Behavioral implication of adult neurogenesis during

stress responses

Lecture Dr Cilene Lino de Oliveira Environment influence on adult neurogenesis

Lecture Dr Lorena Varela Nallar Adult neurogenesis in Alzheimers disease

The audience: Neurogenesis: basic aspects and implications on neuropsychiatric

conditions

Poster presentation Workshop: Neurogenesis: basic aspects and

implications on neuropsychiatric conditions

Seminars in the afternoon

Se
lected students receiving the IBROSs grants

After the seminars