M000-97

Rev. 03 - 10/2007

PHARMA SYSTEM
45-80-120 Models

TECHNICAL MANUAL

Culligan reserves the right to change or modify any technical or design specifications

CULLIGAN ITALIANA S.p.A. - Via Gandolfi, 6 - 40057 Cadriano di Granarolo E. BO (ITALY)

Phone +39/0516017111 fax +39/051765602

Quality System Certified according to UNI EN ISO 9001 Norm

This manual is intended for the Staff specifically appointed to install

and/or operate and/or repair the Culligan systems. Work by unauthorised
staff, or not in accordance with the instructions in the manual, will
relieve Culligan of all liability for the possible consequences.

SAFETY WARNINGS
All handling, maintenance and repair of systems must be carried out by suitably trained staff.
The room which is to house the systems, the accessory material and the consumable products must
comply with the safety, use and storage requirements envisaged by the regulations in force.
The water produced by each device must be used for the specific purpose for which it was
intended. Culligan is not liable for the consequences of improper use of the water produced by its
equipment.
All system malfunctions must be reported to the Culligan Service Centre immediately. Culligan is
not liable for the consequences of protracted use of a system on which malfunctions have
occurred.
Where necessary, chemicals must be selected, dosed and handled by professional qualified staff,
in accordance with the Culligan instructions and the Safety Technical Information.
The system must be disconnected from the electricity and water supplies during all maintenance or
repair operations.
Waste or consumable materials from water treatment systems must be disposed of in accordance
with the regulations in force.

PHARMA SYSTEM
45-80-120 Models

INDEX
-

Preparatory Instructions

Page

Principles of Operation

Maintenance Instructions

13

Trouble Shooting Chart

15

PHARMA SYSTEM
45-80-120 Models
INTRODUCTION
For many industrial and laboratory applications it
is necessary to have water that is highly pure
and that comes as close as possible to the ideal
H2O. To obtain such pure water, special
treatments are needed that are designed to
remove from the water all the substances that it
may contain in dispersed (suspended solids,
colloids, micro-organisms, etc.) or dissolved
(salts, molecules, ions) form.

connected to various uses: automatic analyzers,

operative machines, direct use faucets, etc. It is
able to produce treated water with resistivity > 5
M for 80% of the cycle and of about 1 M for
the remaining 20%. Technically it represents the
most complete range of what is available in
systems of this type. PHARMA is composed of a
primary section for reverse osmosis desalination
and a successive section for a refining
demineralization through mixed bed resins.
CHEMICO-PHYSICAL PRINCIPLES

GENERAL DESCRIPTION
PHARMA is a device that produces ultra-pure
water, designed and conceived to satisfy the
most demanding applications while providing a
simple but complete management of the system.
It brings together the characteristics of safety,
compactness, transportability and quietness that,
added to the constantly high quality of the water
produced, make this the ideal system for
advanced applications. PHARMA is easily

Figure A

Osmosis (see Figure A)

The different level between two saline
solutions of different concentration that due to
the osmotic process draws water from the
diluted solution to the concentrated one.

Reverse Osmosis (see Figure B)

An applied pressure inverts the osmotic
process. This is the principle used for
desalination.

Figure B
semi-permeable
membrane

semi-permeable
membrane
pressure

concentrated
solution

M000-97 - Rev. 03 - 10/2007

pure water

concentrated
solution

PHARMA SYSTEM 45-80-120

pure water

Ionic Exchange
The residual salts at the end of the reverse
osmosis process are dissociated in anionic
and cationic forms.
For example: Table salt dissolved in water
becomes
NaCl------------------> Na+

Reverse
osmosis
desalination
replaceable osmotic modules (10).

Refinishing Demineralization with two

single-use mixed bed resin cartridges that
function alternatively. One cartridge is
therefore kept in reserve (16-17).

Electronic Panel of the touch control type,

with a programmable electronic card (25).

Cl -

The cationic and anionic resins that are

contained in the mixed bed are able to remove
the residual ions that are present at the end of
the osmotic process according to the procedure
described below.
Cationic resins in acidic form (R-H) are used,
which are able to exchange their Hydrogen (H)
with the water's cation:
R-H + Na+ --------------> R-Na + H +
and anionic resins (R-OH), which are able to
exchange the oxhyhydrogen (OH) with the anion:
(R-OH) + Cl- -------------> R -Cl + OH These reactions, described for Sodium chloride,
occur as well with all other cations and anions
and, observing the results of the above reported
exchanges, one can see that water is produced:

controls, gauges, timer, by-pass, alarms, etc.

for a correct, optimal and programmed use of
the system.

A reduced sized cabinet that is easily

transported.

Internal sound-proofing panels.

Simple hydraulic and electrical connections

for quick use.
Note: all the hydraulic components used in
PHARMA systems are made of materials
that resist to corrosion, that are suitable
for food and medical use and designed to
withstand, by a large margin, the normal
operation of the system.

In many systems demineralization is achieved by

percolating water first through a cationic resin
and then through the anionic one.

Note: PHARMA is conceived to reduce as much

as possible work interruptions due to
maintenance. Therefore it is equipped with
two
MB
columns
that
function
alternatively.
PHARMA COMPONENTS
(see Figures Nos 1 and 2)
PHARMA
phases:

includes

the

following

treatment

continuous quality control of product

water [with commutation of osmotic waterdemineralized water (4)].

Composite pre-filtration with quick

with

In addition, it is equipped with:

H+ + OH - --------------> H 2O

In the PHARMA the resins are intimately mixed

(mixed bed) so as to constitute an enormous
succession of complete deionizers. In this way
the exchange capacities are heightened and the
quality of the product water reaches the highest
standards not obtainable with other systems.

installation replaceable cartridge (3).

Pressurization with high pressure pump (8).

OPERATING
LIMITS
CHARACTERISTICS

AND

TECHNICAL

PHARMA is by definition designed to produce

water of exceptional purity; it is therefore
necessary that the feed water be of a quality
consistent with potable water.
Characteristics of
(admissible values)

Water

to

be

treated

T.D.S.

< 1000-1500 ppm

(based on chemical
composition)

Temporary hardness
Iron
Manganese
Chlorine
Turbidity
Temperature
Feed Pressure
Feed Capacity

:
:
:
:
:
:
:
:

< 35f
< 0.1 ppm
< 0.05 ppm
< 0.4-0.5 ppm
< 5 NTU
5-30C
> 1.5 bar
> 500 l/h

PHARMA SYSTEM 45-80-120

M000-97 - Rev. 03 - 10/2007

Figure No. 1

FLOW DIAGRAM PHARMA 45-80

N.

DESCRIPTION

N.

DESCRIPTION

N.

DESCRIPTION

PRESSURE

10

MEMBRANE

19

SOLENOID VALVE (SV2)

FILTER INLET VALVE (BLACK)

11

CHECK VALVE

20

CELL (C1)

FILTER

12

SOLENOID VALVE (SV3)

21

CHECK VALVE

MULTI-FUNCTION DISPLAY

13

PRESSURE SWITCH (MAX)

22

NEEDLE VALE (REJ)

SOLENOID VALVE (SV4)

14

HYDROBOX

23

CHECL VALVE

PRESSURE SWITCH (MIN)

15

CELL (C2)

24

R.O. BY-PASS VALVE (RED)

INLET PRESSURE GAUGE (LOW PRESSURE)

16

DEIONIZER (MB1) 10 l

25

CONTROL PANEL

PUMP (P1)

17

DEIONIZER (MB2) 10 l

PUMP PRESSURE GAUGE

18

SOLENOID VALVE (SV1)

Optional Pre-treatments

- Pharma 120

160 l/h

To meet the norms described above, it may be

necessary to provide for an external pretreatment of the water before it enters the
system
based
on
its
chemico-physical
characteristics
(for example: high turbidity, presence of Iron or
Manganese or anomalous presence of Silica).

Recovery Ratio

20%-30%

HP Pump Power

0.42 kW

Operating Pressure

13-14 bar

Product Residual Salinity :

Reverse Osmosis Section Characteristics

(relating to standard water conditions and
temperature at 18-20C)

Exchange Capacity

220 g CaCO 3

Max Flow Rate

~160 l/h

Demineralized Water
Resistivity

> 5 M for 80%

of cycle

Product Flow Rate

- Pharma 45
- Pharma 80

M000-97 - Rev. 03 - 10/2007

:
:

4-6% of initial
salinity

Mixed Bed Demineralization Section

Characteristics (for Each Refill)

80 l/h
120 l/h

~1 M for the
remaining 20%
PHARMA SYSTEM 45-80-120

Figure No. 2

FLOW DIAGRAM PHARMA 120

N.

DESCRIPTION

N.

DESCRIPTION

N.

PRESSURE

10

MEMBRANE TW4021

19

SOLENOID VALVE (SV2)

FILTER INLET VALVE (BLACK)

11

CHECK VALVE

20

CELL (C1)

FILTER

12

SOLENOID VALVE (SV3)

21

CHECK VALVE

MULTI-FUNCTION DISPLAY

13

PRESSURE SWITCH (MAX)

22

NEEDLE VALE (REJ)

SOLENOID VALVE (SV4)

14

HYDROBOX

23

CHECL VALVE

PRESSURE SWITCH (MIN)

15

CELL (C2)

24

R.O. BY-PASS VALVE (RED)

INLET PRESSURE GAUGE (LOW PRESSURE)

16

DEIONIZER (MB1) 10 l

25

CONTROL PANEL

PUMP (P1)

17

DEIONIZER (MB2 10 l

26

MEMBRANE TW4014

PUMP PRESSURE GAUGE

18

SOLENOID VALVE (SV1)

Dimensions
-

Length

500 mm

Depth

500 mm

Total Height

1450 mm

Weight
- Pharma 45
- Pharma 80
- Pharma 120

:
:
:

123 kg
130 kg
140 kg

In the re-finishing phase, we have adopted

single-use resins, since they offer better
exchange characteristics compared to normal
regenerative resins, and they eliminate the
bother and costs associated with handling the
containers for periodic regeneration.
A device for partial recycling and timing provides
for continuous or intermittent use, always
maintaining the quality of product water at the
highest levels.

PHARMA has been conceived with criteria of

rationality and simplicity: given that the system is
to be fed with potable water, a pre-treatment
softening phase has been excluded since
practical and economic considerations favour the
use of replaceable membranes (whose average
life is in any event above 18 months).

DESCRIPTION

A second timer signals, with an acoustical and

visual alarm, when it is advisable to replace the
pre-filtration cartridges.
The quality of product water is constantly
monitored by a conductivity meter, which can
test either the purity of the treated water or of the
osmotic water.

PHARMA SYSTEM 45-80-120

M000-97 - Rev. 03 - 10/2007

COMPONENTS DESCRIPTION
(see Figures Nos 1 and 2)

a) Composite Pre-Filtration (3)

It is able to remove impurities that are not
dissolved such as sand, turbidity, oxidized
Iron, etc., with a filtration level of about 510 m. The activated carbon present in the
filter reduces Chlorine in the water as well as
pesticides, THM, micropollutants, etc.

MB Refill: because of practical and

economic considerations the MB columns
are replaceable as refills. In this way the
necessity of the premises regeneration is
eliminated, as well as the costs and
handling that regeneration at a specialized
facility involves. The refill containers are
an integral part of the system and can be
installed simply, economically and quickly.

e) Electronic Panel (25):

b) HP Pump (8)
The R.O. system high pressure pump is able
to provide 400 l/h with a P of 13-14 bar. It is
equipped with high pressure by-pass valve.
c) Osmotic Module (10 - 26)
The membrane is able, thanks to the high
pressure of the entering water, to remove
about 95% of dissolved salts in the feed
water. The lack of a pre-treatment softening
phase simplifies considerably the operation of
the system. It is necessary though to perform
a systematic control of the operative
parameters
to
ascertain
the
correct
functioning of the membrane. This will allow
for the best use of the osmotic membranes
(which should last for more than 18 months).
d) MB Demineralization (16-17)
Osmotic water, although highly pure, is not
always guaranteed to have the resistivity
qualities necessary for certain uses that
require ultra-pure water. It is therefore
necessary to employ mixed bed exchange
resins for a refining process. To this end two
important innovations have been installed in
the PHARMA:
-

Double MB: it allows one not to interrupt

the operation of the system because of
long and bothersome replacements of the
MB resins column. The electronic panel
advises in advance when the resins are
expiring. Through the touch control the
new MB column is activated, leaving in the
memory the signal to replace the expired
one.

M000-97 - Rev. 03 - 10/2007

Touch control type with a programmable

electronic card. It allows for the simplest and
complete management of the system. It is
equipped with a digital conductivity meter (4)
that can make two readings depending on the
option selected: either of the osmotic water
and then, releasing the key, of the
demineralized water. The programmable card
controls the following parameters:
-

frequency of composite filters

replacements

delay of pump shut-off for intermittent

use of the system (optimization of system
functioning)

other functions.

f) The PHARMA is in addition equipped with:

-

quality recycle in start-up phase

by-pass of osmotic section in emergencies

(only the demineralization section is in
operation)

continuous visual and acoustic alarm

signals. The acoustic signal (except when
manually
interrupted)
lasts
for
120 seconds

a beep sound to acknowledge keyboard functions

automatic test of the LEDs on each

switching on

memory stores current function in the event

of power black-out.

PHARMA SYSTEM 45-80-120

Figure No. 3

ELECTRONIC PANEL TERMINAL BOARD

IN

CONDUC.
METER
200 uS

EXT1

CONDUC.
METER
20 uS

PS+
33 32 31 30 29

PS-

FUSE 250mA +5V

FUSE 2A +24V

28 27 26 25 24 23 22 21

1 2 3 4

5 6 7 8 9 10

11 12 13 14 15

GND

16 17 18 19 20

~ ~

PUMP
OUT

FUSE
PUMP
4A

GND

POWER
220V

FUSE
POWER
500mA
FUSE
POWER
500mA

Outlets 9-10 : 24 V/12 W

PHARMA SYSTEM 45-80-120

M000-97 - Rev. 03 - 10/2007

Preparatory Instructions

The PHARMA SYSTEM is shipped in a single

package containing the system and all
accessories:
A)

the PHARMA SYSTEM cabinet

B)

two rapid system filter cartridges

C)

a package containing the fittings for

hydraulic links.

flooding the area in case of leaks or

breaks in the hydraulic links).
E)

Have an electrical outlet near the system

protected by a high sensibility differential
switch appropriate for the system's power
requirements (see: "Operating Limits and
Technical Characteristics" on page 2).

HYDRAULIC LINKS
PHARMA SYSTEM POSITIONING
A)

B)

Once the system has been removed from

the package, place it as close as possible
to the point it will be used, paying attention
that it is protected from atmospheric
agents, gas or corrosive chemical agents
that may be present.
Have near the system a " pipe equipped
with a valve, to provide feed water for the
system.

C)

Have a water drain near the system.

D)

If possible, have a drain hole on the floor

where the system is placed (to avoid

M000-97 - Rev. 03 - 10/2007

At the rear of the system there are the fittings for

the hydraulic connections labeled as follows:
IN

Inlet
of
feed
diameter 12 mm.

water

PRODUCT

Outlet of demineralized
water diameter 8 mm.

REJECT

Outlet
waste
diameter 10 mm.

water

The system comes with a kit containing the

accessories needed to fit the hydraulic links,
including: flexible tubes, fittings, etc

PHARMA SYSTEM 45-80-120

Principles of Operation

When the plant is electrically powered, the

display shows:

The display shows RECIRCULATION 2 and

PHARMA stays in this state for 5 minutes after
which it goes onto PAUSE (shown on the
display).

PHARMA 45-80-120 Std by Culligan Italia .

Pressing OPERATE starts the STARTING cycle:
in this condition the solenoid valve SV 4 opens;
with a time lag of 5 seconds (time needed to
pressurize the system) the pressure switch PS(6) is inhibited for 5 seconds after starting the
pump P (8) to prevent intermittent starting. If on
re-enabling the pressure switch PS- the pressure
turns out to be insufficient, PHARMA goes into a
low-pressure alarm. The display will show
PRESSURE ALARM + beep.

This situation remains until with water being

required the minimum level is reached in the
tank (pressure switch will close the contact
PS+), PHARMA will then accordingly run the
RECIRCULATION 1 and then the SERVICE
phases.
The
quality
of
the
water
produced
(demineralized) is shown on the display during
the SERVICE phase, together with the MB in
service. MB service may be alternate by
pressing CHANGE touch (the display will show:

With sufficient pressure the pump assembly

stays running, supplying the module with water
pressurized at 13-14 bars. Each start-up
involves automatic recirculation, the plant
partially washes the module with osmotized
water according to the following procedure:

REPLACE MB* -MB*

Ent YES, Res NO
Pressing MENU (ENT) the MB bottle previously
in stand-by will enter in service.

The display shows RECIRCULATION 1 and the

countdown in seconds of the relevant phase:
- The pump-motor unit P starts running and
supplies the module with pressurized water. At
the same time, the solenoid valve SV 3 is shut
for 30 seconds shown on the display thereby
making it possible to recirculate the osmotized
water on the module via the one-way valve
(23).
After the set time, the solenoid valve SV 3
opens and the water produced (desalinated) is
sent to the active mixed bed demineralizer (16
or 17) and to the service. The electric panel will
display:

DESCRIPTION OF THE CONTROL KEYPAD

When the keypad is used a beep signals the
function has changed over.
- OPERATE
When pressed, the starting cycle commences
and the plant can be put on standby
instantaneously.
-

SERVICE QUAL OK *** S.

Likewise, with each stop the plant partially
washes the module with osmotized water. If the
user requires no water, the "product" line is
pressurised and the Pressure switch PS +
stops the service.
PHARMA goes onto
standby with a last recirculation, following the
same procedure described in the initial module
washing phase.
8

CHANGE
If the quality alarm should persist (a clear
sign of MB exhaustion), it will be necessary to
commute the MBs (for example: from 1 to 2).

Press the CHANGE key to commute.

Press the MENU key to confirm, or

Press RESET key to cancel.

At the next pause, REPLACE MB will be
displayed
This procedure is recommended only when the
MB Refill is actually exhausted
-

PHARMA SYSTEM 45-80-120

M000-97 - Rev. 03 - 10/2007

ALARMS
- In an alarm condition, no matter what the
cause, pressing RESET silences the
buzzer.
- However,
ALARM is still shown on the display to
indicate its nature.
- To
stop
ALARM being displayed, press
RESET
again.
This is only possible if the cause of the alarm
has been removed.
-

MENU (Enter)
This key is employed during the service in
order to display R.O. water quality. During
settins, it confirms set parameters, and goes
to next step. During MB change, it confirms
required replacement.
- e + if pressed at the same time, they
enable to access to the setting or modifying
of set values.

Silence the buzzer by pressing RESET,

restore the fuse with the machine switched off
and then restart.
Before performing this operation,
disconnect the plug (disconnecting
switch)
-

This blinking visual alarm appears when the

water conductivity is 20% more than the set
alarm point (Q. SET).
This shows the mixed bed refill column will
soon need to be changed.
-

DESCRIPTION OF ALARMS AND SIGNALS

N.B.: All alarms are enabled
machine switched on.
-

with

the

PRESSURE ALARM (low-pressure alarm)

Sound and blinking visual alarm.
Unless the operator presses RESET, the
sound alarm automatically silences after 2
minutes (the visual alarm on the display
keeps on blinking).
When the pressure is restored, the plant is
automatically activated.
If the alarm comes on for more than 5 times
in a time of 10 minutes, PHARMA shuts
down. To restart you will need to press
MENU + RESET.

PRE ALARM

QUALITY ALARM
The quality of the water is controlled by the
conductivity meter (with Set point Q. SET set
on approximately 1.4 S/0.7 M ).
When the water conductivity exceeds the set
limit,
Q. ALARM blinks on the display.
The real alarm only appears if the conditions
of poor quality remain for 2 minutes with
buzzer activation.
N.B.: If RESET has not been pressed after 2
minutes the buzzer silences itself. If the
water quality comes within the limit the
buzzer automatically silences itself with
Q. ALARM displayed steady as a
reminder of the alarm occurring.
Notes: The quality alarm does not stop any of
the system's functions.

IN PAUSE
During pause all alarms are desactivated.
Nevertheless, the display will show the
alarms memorized before service stop.
The main alarm which might be memorised is
the QUALITY ALARM.
RESET hey will cancel alarms.

TRIP ALARM
A sound and blinking visual alarm activated
by the fuse protecting the pump-motor
blowing. It is the cause of short circuiting or
abnormal motor input current.

In case the Filter replacement alarm is

memorised, the signal REPLACE FILTER is
displayed. Anyway, the QUALITY ALARM, if
any, will be displayed first.
Press RESET to cancel alarm.

M000-97 - Rev. 03 - 10/2007

PHARMA SYSTEM 45-80-120

REPLACE FILTER
When the filter timer has reached the set
time,
the
plant
will
go
into
a
REPLACE FILTER alarm.

Q. SET

: This option makes it possible to

set the water quality alarm from
0.1 to 20 S (default 1.4 S).
Use + and to edit the set
value.

COND. 1

: This enables calibrating the

conductivity
meter
0-20
S
demineralized water.
By using a resistor or a sample
solution it is possible to adjust the
value on the display by pressing +
and - .
If, at the time of calibration, the
value on the display corresponds
to that of the sample, you will still
need to press - once and + a
second time to confirm the
programming.
Use a buffer solution of 20 S or a
resistor of 100 k .
N.B.: If when reading this menu
you mistakenly press + or
- you will need to do the
calibration again.

COND 2.

: for R.O. water conductivitymeter

calibration (0-200 S), by means
of a test solution 20 S or of a test
resistance 10 K
to be
connnected during calibration.

PHARMA SYSTEM 45-80-120

M000-97 - Rev. 03 - 10/2007

Alarm display will appear only during next

pause, in second line
N.B.: The plant will not shutdown but will
keep on working in the alarm condition.
To be able to get rid of the message you
need to press RESET and + together.

PROGRAMMING
With the plant on standby, press
+
and
- together for 5 seconds until the buzzer beeps.
The
MENU button takes you through the
selections of the EDITOR settings.
DAYS

10

: This option makes it possible to

decide the life in days of the prefilter cartridge in the machine.
It can be set from 2 to 20 days.
Where one day corresponds to 24
hours of machine operation
(default 20 days).
Use + and - to edit the set
value.

Start-up Instructions

CHECKING AND REGULATIONS

(see Figures Nos 1 and 2)

RR =

The system is shipped from the factory already

tested and adjusted. However, it is necessary to
proceed to an initial setup as follows:
1)

open the feed valve.

2)

Make sure that the by-pass adjustment screw

of the high pressure pump is partially open.

3)

Open the reject water valve (13).

4)

Disconnect the osmotic water tube from the

demineralizers and convey it to the drain.

5)

Plug in the
OPERATE key.

6)

After the programmed delay, the solenoid

feed valve opens and the pump starts
operating. The product and reject water will
start flowing to the drain.

7)

PHARMA.

Press

Example:
-

Product water (osmotic) flow: 80 l/h.

Reject water flow: follow the parameters

suggested on page 3 Characteristics of the
Reverse Osmosis Desalination Section for
Recovery Ratio (RR)

M000-97 - Rev. 03 - 10/2007

x 100

considering that the temperature, salinity

and feed water pressure could change
appreciably the final adjustment.
8)

the

Adjust reject water regulating valve (13) in

order to obtain the same reject flow as
specified in Operational Limits and
Technical Characteristics (page 2-3).

product water
feed water

9)

Operating pressure: 13 to 14 bar.

Check the operating pressure on the pump

pressure gauge. If the pressure in not
between 13 and 14 bar, carefully adjust the
high pressure pump by-pass valve until the
gauge shows a steady pressure.
Note:

when performing this operation make

certain that the high pressure pump
by-pass valve is never completely
closed.

Note:

the minimum pressure switch (PS-)

has been preset at a minimum
pressure of 0.7 bar.

Temporarily stop the PHARMA by pressing

the OPERATE key.

10) Restore the connection of the osmotic water

to the demineralizers and repeat the
procedure
by
pressing
the
OPERATE key again.
11) After this initial cycle, the osmotic water is
sent to demineralizers. It will take a few
minutes to fill up the MB.
12) Check on the control panel is indicating that
the quality of the demineralized water is
good..

PHARMA SYSTEM 45-80-120

11

Maintenance Instructions
1) ALTERNATING AND REPLACING THE MB
CARTRIDGE
- It is possible to alternate the bottles also
during service. Replacement of cartidges
can only be carried out during stops.
- Move the valve (2) lever downward
(DRAIN position).
- Open the valve (24) (R.O. by-pass).
WARNING: wait about one minute to give
the system time to release pressure.
- Disconnect the exhausted MB container
by unfastening the quick-release clamps
(blue and green).
- Open the containers holding belt and
remove the MB container to be replaced.
Note: it is suggested that a sink or drain
be nearby.
- Unscrew the clamp and disassemble the
cover.
- Take out the cartridge of the exhausted
resin.
- Insert the new cartridge making sure that
the upper and lower caps have been
removed from the cartridge.
- Place the removed caps on the exhausted
cartridge and dispose of it.
- Close the MB housing with its coveer.
- Reposition the clamp
- Reposition the MB housing in its seat.
- Reinstall the respective connections of the
MB housing (blue to blue, green to green).
- Tighten the housing with the belt.
- Bring the valve (2) lever upward to the
SERVICE position.
- Close the R.O. by-pass valve (24).
- Restart
the
system
by
pressing
OPERATE .
2) MB RESET
(To be done after the exhausted MB cartridge
has been replaced).
After commutation from MB 1 to MB2, the unit
will display Replace MB *

12

Press RESET key to cancel this message.

Now it is possible commute again the MB
In case of several commutation without
Pharma stops only the last change will be
displayed.

3) FILTER REPLACEMENT
With Pharma in stand- by the signal
REPLACE FILTER will be displayed..
- Move the valve (2) lever downward
(DRAIN position).
- Open the R.O. by-pass valve (24).
WARNING: wait for about a minute to
give the system time to release
pressure.
- Replace the filter cartridges by turning
clock-wise and removing from the
bottom. To insert the new filter reverse
the above procedure.
- Move the valve (2) lever upward to the
SERVICE position.
- Close the R.O. by-pass valve (24).
- Restart the system by pressing
OPERATE .
- Reset the filter replacement timer by
pressing simultaneously + and RESET
- Now the filter timer is off.
4) EVENING OR WEEKEND PAUSE
-

Stop the system by pressing OPERATE .

To restart the system press

again.

OPERATE

DESALINATOR BY-PASS
The desalinator may be by-passed
malfunction prevents it from starting up.

if

To do this, use valve (24) (see Figures Nos 1 and

2) to feed the mixed bed directly with in-line water.

PHARMA SYSTEM 45-80-120

M000-97 - Rev. 03 - 10/2007

Trouble Shooting Chart

Problem

1) The LED is hooked to

power supply and the
OPERATE is not lighted

2) System with activated

OPERATE, lighted ALARM
for low pressure and the
high pressure pump (8) not
functioning.

3) The operating pressure of

the pump is too low.

4) Product water (desalinated)

of bad quality.

M000-97 - Rev. 03 - 10/2007

Cause

Remedy

A)

No power is reaching the

power outlet.

a)

Check and fix the cause.

B)

The power cord is

interrupted.

b)

Check and change the cord.

C)

Circuit breakers are

burned.

c)

Check and replace after

having determined the
cause.

A)

The feed water pressure is

below 0.7 bar.

a)

Check that the feed water

valve is open.

B)

The feed valve is closed.

b)

Check that the feed water

valve is completely open.

C)

The RAPID SYSTEM filter

cartridge is clogged.

c)

Check and if necessary

replace the cartridge
following the procedure in the
technical manual.

D)

The low pressure switch

[PS-] is out of calibration
or it is defective.

d)

Check and adjust or replace

the low pressure switch.

E)

The solenoid valve [SV(4)] is defective.

e)

Check the solenoid valve and

replace it if necessary.

A)

The high pressure pump

by-pass valve is out of
adjustment.

a)

Check and adjust the high

pressure pump by-pass
valve.

B)

The high pressure pump

is defective.

b)

Replace the high pressure

pump.

C)

The osmotic module is

defective.

c)

Check and after having

determined the cause
replace the osmotic module.

A+B) The characteristics of

the feed water have
changed.

a)

Check the feed water.

b)

Modify the feed water pretreatment.

C)

The reject valve is closed

or partially closed.

c)

Check the reject water flow

rate and adjust the reject
valve.

D)

The R.O. by-pass valve is

completely open.

d)

Check and close the valve

(By-pass RO).

E)

The osmotic module is

deteriorated.

e)

Proceed to a chemical
cleansing of the osmotic
module and if the quality of
the product water does not
improve replace the module.

PHARMA SYSTEM 45-80-120

13

Problem
5) Low product water flow
(desalinated).

6) The system does not wash

the osmotic module each
time water use stops.

7) The demineralization
column is exhausted in a
too short time.

14

Cause

Remedy

A)

The high pressure pump

(8) is broken.

a)

Check the operating

pressure of the high pressure
pump and if it is below 14 bar
replace it.

B)

The osmotic module is

fouled by Calcium salt.

b)

Proceed to a chemical
cleansing of the module and
if desired results are not
achieved replace it.

A)

The timer placed in the

electronic panel is broken.

a)

Check and replace it if

necessary.

B)

The maximum pressure

switch is out of
adjustment or broken.

b)

Check and replace it if

necessary.

C)

The holding valve on the

recirculation loop is
blocked or closed.

c)

Check and replace it if

necessary.

A)

The product water from

the osmotic membrane
has excessive salinity.

a)

Check the salinity of the

osmotic water and replace
the membranes if necessary.

B)

The by-pass valve is

open.

b)

Check and close the valve.

PHARMA SYSTEM 45-80-120

M000-97 - Rev. 03 - 10/2007