Arno Simon, Ingo Green

Empower3
A Compact User Guide

DEAR READER,
Empower3 is a chromatographic data system (CDS), mainly
applied in pharmaceutical industries, in the area of life sciences
and biotechnology. Due to stringent regulatory and functional
requirements as demanded of the industry, most users will confirm a CDS not to be fully comprehended just along the way.
Missing knowledge of the software can be hindering at times for
one to fulfill their laboratory duties in a timely manner. Usually
CDS operators are happy to have found and be shown a suitable
way for using Empower in order to obtain the desired results.
Having established such a way, most will consequently adhere to
it, despite this not being the best possible way and Empower not
being used to its full potential.
For example, calculations are still being performed in Excel due
to the lack of knowledge about Empowers ability to perform
the desired calculation. Or there may be uncertainties of understanding Empowers method of calculation. Without the necessary understanding and familiarity, changes to ones proven and
established routine can result in a lenghty challenge in order to
make these changes. During day-to-day laboratory routine, its
often impossible to find the time for gaining a deeper understanding of the software and its full scope of functionality.
The attendance of training courses, if available, can be regarded
as a starting point or a small stepping stone in acquiring software knowledge. A deeper and lasting understanding can only
be achieved with lots of practical and daily laboratory routine.
This manual is intended to support you in mastering the use of
Empower in a simplified and easy to understandable way. As a
compact manual its not the intention to create a mirror image of
the Empower Online-Help but to provide a user-friendly leitmotif
thereby focusing on the essentials.


Aspects to be considered as relevant and important will be
discussed in more detail throughout this book. At various passages, references are made to the producers documentation (i.e.
Waters), thus avoiding an information overload and keeping the
manual as compact as possible. By doing so, this manual serves
as a solid help for new Empower users to get started and as a
reference for those users already experienced in the routine use
of the CDS software.
Should you have any suggestions or just like to give feedback regarding this manual, we look forward hearing from you.
Thereby making a valuable contribution in improving and developing this manual further.
Sincerely yours,
Arno Simon and Ingo Green
Any suggestions or feedback can be forwarded to the following
e-mail address:
empower.manual@beyontics.com

AT A GL ANCE
1 Editions and Network Architecture 15
2 Quickstart-Interface  19
3 Project Window  32
4 Data Acquistion  56
5 Data Processing  98
6 Reports  222
7 Data Import and Export  278
8 Configuration Manager  294
9 Custom Fields  356

CONTENT
Introduction14
Editions and Network Architecture

15

Empower Personal Edition  18

Empower Workgroup and Enterprise Edition  18
Citrix Terminal Server  19

Quickstart-Interface 

19

Accessing the Quickstar t-Interface  22

Overview of the QuickStar t-Interface  23
Run Samples  24
Browse Project  27
View Data  28
View Method  29
Show Me  29

Project Window 

32

Logon Procedure 32
Empower Online Help  33
Help - Contents  33
Help - Search  33
Overview of Empower Structure  33
Opening Projects  34
Project Structure 34
Project Names 35
Project Selection 35
Structure of Project Window 35
Project Window Title Bar  36
Tables within the Project Window 36
Project Window Menu Bar  39
Review  40
Compare  40
Preview/Publisher  40
Process  40
Print  40
Export  41


Alter Sample  41
Process Only Sample Set  41
Run Sample  41
View Filter  42
Application Preface  42
Adjusting Table Columns 42
Deleting Table Columns  44
Adding a Table Column 45
Saving a View Filter 45
Filtering Table Entries 46
Creating a Static Filter 47

Data Acquistion 

56

Run Samples Window  57

Overview of the Run Samples Window  57
Online-Plot  58
Most important Instrument Method Setting 59
Instrument Method  60
Saving of a Method  61
Method Proper ties 62
Method Set  63
Method Set Wizard  64
Instrument Method Editor  65
Baseline Monitor  67
Single Injection 68
Setup and Start of a Single Injection 68
Aborting a Single Injection  70
Sample Sets  70
Manual Setup of a Sample Set  70
New Sample Set Wizard  71
Formatting a Sample Table  80
Sample Sets with Bracketing  82
Excursion: Function RF Internal Standard in Empower 84
Editing a Sample Set  85
Autofill  85
Alter Sample  86
Process-Only Sample Sets  86
Creating a Process-Only Sample Set  87
Sample Set Methods  91


Loading a Sample Set Method  91
Saving a Sample Set as Template  92
Starting a Sample Set  92
Aborting a Running Sample Set  93

Data Processing 

98

The Review Window 98

Adjusting the Review Window View  100
The Toolbar of the Review- Window  100
The Five Main Views of the Review Window 101
Result Audit Viewer 103
Further Review Navigation Options 104
Overlay  104
Integration Parameters  111
Creating a Processing Method  112
Defining a Processing Method Type 113
Defining an Integration Section  114
Setting of Peak Recognition Parameters  114
Defining Peak Exclusion Values  115
Calibration Parameters  116
Creating a Component Table  118
Entering Default Amounts  119
Defining an Internal Standard  119
Input of System Suitability Criteria 120
Saving a Processing Method  120
Integration Method Parameters 121
Integration  122
Traditional Integration  123
ApexTrack  126
Purity 135
PDA Library Search 136
Components  136
Impurity 144
Peak Ratios (MS Ion Ratios) 151
Default Amounts/Purity 152
Named Groups  153
Timed Groups  154
Suitability  155

Excursion: Noise and Drift Values in Empower 156


Limits  162
Noise and Drift  162
Automated Calibration and Quantification  164

Excurion:Useful Presettings in Review 166

Manual Calibration and Quantification  166
Creating a Calibration  166
Calculation of Standards  169
Results Windows  170

Excursion: Response, RF, Relative Response, Response Factor

What does it mean? 171
Calibration Curve  174
The Calibration Curve  174
Excursion: Internal Standard in Empower 177
Saving a Calibration  178
Quantifying a Sample 178
Saving a Result 180
Processing via Channels in the Method Set 181
Excursion: Subtraction of a 2D Blank Value 182
3D Evaluation  184
3D Data in the Review Window 184
3D Plot  186
Editing Viewing Options 187
Contour Plot  188
Chromatograms / Spectra  189
Method Set - Save Extracted Channels  193
PDA Processing Method  194
Spectral Library 203
Adjusting a PDA Processing Method  210

Reports 

222

Repor t Publisher  222

Most Relevant Terms 222
Report Method  222
Report Publisher  222
Report Publisher (Preview)  223
Report Group  223
Presenting Individual Results  223
Loading a different Report Method 226
Automated Printing of Selected Results 227

10


Creating Reports from Sample Sets Automatically 229
Editing Existing Repor t Methods  229
Selecting Results and Starting the Preview/Publisher 229
Report Method Properties  230
Illustrating Chromatograms 234
Designing Repor t Methods  251
Individual Reports 251
General Advices 255
Grouping  256
Composite Groups  256
Sorting Order 257

Excursion: Scalability of Chromatograms in Locked Repor t

Methods 260
Peak Table  261
Creating Tables  261
Modifying Table Properties 261
Statistical Functions in Report Tables  262
Summary Repor t  268
Excursion: Sor ting and Grouping Options for the Design of
Separate Peak Tables 269
Printing Repor ts  271
Saving Repor ts as PDF  271
Global Default Settings 272

Data Import and Export

278

Impor ting Data 278

Restore Function 278
Import Function 279
Copy&Paste 279
Drag&Drop 280
Waters Data Converter 280
Importing Plate Types 280
Expor ting Data 281
Backup Function 281
Export Method 281
Export to Text 288
Copy & Paste 289
Archiving of Projects 289

11


Toolkit Applications 289
Migration of Spectral Libraries 290
Copying of Spectra from the Source Instance  290
Importing Data to the Target Instance 290

Configuration Manager 

294

Star ting the Configuration Manager  294

System Policies  295
Empower Message Center 302
Default Strings  305
Copy Preferences  306
Projects  308
Projects in Empower  308
Creation 309
Maintaining Projects  313
Data Backup  316
Locking and Unlocking of Projects 322
Cloning of Projects 323
Global Projects View 324
User Management  326
User Groups  327
User Types  330
User  332
Systems und Nodes  340
Creating of Empower Nodes  340
Setting up a new System  345
Changing the Configuration of Chromatographic Systems  348
Online and Offline State of Chromatographic Systems  350
Libraries  351
System Audit Trail  352

Custom Fields 

356

Introduction 356
Data Types  359
Field Types  359
Sample Field 360
Sample Set Field as Enum 362
Result Field  365
Component Field  369

12


Peak Field  373
Interpeak Calculations  377
Calculated Enum Field  380
Intersample Calculation  382

Index386

13

INTRODUC TION
This Empower manual is an accurate english translation of the
German-language edition from the year 2015. It explains and
describes the functions and operations based on Empower Build
3471 Feature Release 2 containing the options PDA and System
Suitability. As no fundamental changes have occurred since
then, the manual is still valid and suitable for those working
with earlier versions of Empower. Added functions which are
specific to Empower3 are recognizable by the Empower3 logo at
the page margins throughout this book.
To preserve the compact character of this manual, any illustrations regarding Mass-Spectrometry (MS), Dissolution, Capillary
Electrophoresis (CE) and Size Exclusion Chromatography (SEC) as
well as special topics on Gas Chromatography (GC) have not been
included for this purpose.
For the same reason, no illustrations of instrument methods for
operating various instrument types or a selection of controllable instruments has been included. The multitude of options for
operating / controlling instruments from different vendors has
reached an extent which cannot be covered in a compact manual
like this. Thus, running the risk of being out of date very quickly.
Furthermore, sufficient information is provided by the various
vendors themselves and any further re-description in this manual not being required.

Excursion

This book has been enhanced with multiple excursions, partially

offering more in-depth information on special topics not being
covered by the Empower Online-Help as well as answering questions which are frequently forwarded to service provider.
Particular functions and fields are displayed completely and in
form of a table, thereby facilitating the use of this manual.
The Empower software possesses an user-management. When
describing the individual roles, we are assuming for the user

14


to hold the respective user-rights. During day-to-day laboratory business, it can happen that certain functions cannot be
selected or performed, depending on the assigned or selected
User Type. Especially deletion and administrative tasks are not
accessible for the regular user.
Topics and comments of a certain importance or which provide
complementary information are included in appropriate text
boxes found inside the page margins or, depending on the volume, within a page-sized frame complementing the respective
chapter. Depending on the category (topic or comment) the text
box will contain either an exclamation mark or an information
symbol.

15

Project Window

Below the window title, as with all other Windows programs is

the menu bar ( File , Edit , View , Tools , Database and Help ) and the
toolbar. Here you can find the tools which also can be selected
from the menu item Tools .
A similar list can be obtained via right mouse click on the project table. The table itself contains all project data such as chromatograms, methods and results.
The requested information is obtained by selecting a particular
tab, which is indicated on top of the table. Alternatively, you can
select the menu item View .

3. 7. 1Project Window Title Bar

In the title bar of a project window the user name and selected
user type is displayed beside the current project name and the
used database. The user type defines the granted privileges to a
user account, e.g. the deletion of data can be denied. Especially,
when working with several projects, care should be taken, to
always make the correct selection. Otherwise, data acquisition
can be performed in the wrong context and data are stored to
the wrong project.

3. 7. 2Tables within the Project Window

Within the project window, the content of 13 different tables can
be displayed by clicking on the respective table title.

36

Structure of Project Window

Sample Sets
A Sample Set is a sequence of several injections that were
acquired in a set. By double-clicking on a row, the view switches
to the Injections table, where a list of all injections is displayed
that are part of the selected Sample Set .

Injections
Injections are the acquired chromatographic raw data together
with all chromatograms (Channels ). One injection can consist
of at least one or several Channels . If more than one detector is
used during an acquisition, each data signal is stored as a single
Channel related to the respective Injection . By double-clicking on
a row, the view switches to the Channels table and displays all
Channels associated to this Injection .

Channels
A Channel is the most in-depth level of information of the
acquired data, i.e. a single chromatogram that has been generated inside a detector and stored electronically. For other signals, such as pressure or temperature curves, separate Channels
are created.

Methods
Here, various types of Methods within a project will be displayed.

Method Description

Function of the Method

Instrument Method

Method for controlling data acquisition

Processing Method

Evaluation method

Report Method

Method for reporting results

Export Method

Method for exporting data

Sample Set Method

Method for creating a sample set

Sample Set Method Template

Template for sample set methods

Method Set

Set for gathering different methods

37

Project Window
Result Sets
Where a Sample Set is processed automatically, a Result Set is
generated. A Result Set consists of several single Results that
derive from the same Sample Set . By double-clicking on a row,
the view switches to the table Results , where all single Results
are displayed, that belong to the selected Result Set .

Results
Results are the calculated output of a single Channel.
Peaks
Here, a list of all components within a project, for whom a calculation was performed, can be found. Displaying even unknown
and missing components.

Fractions
A Fraction is a section of a chromatogram that results from a
cut detector signal. After detection, chromatographically separated compounds from the initial sample solution are collected
by Fractions in different vials. These Fractions represent the
chromatogram sections. Fractions are always associated to an
Injection , thus to a Sample Set .

Sign Of fs
Here, electronic signatures can be displayed.

Curves
Here, all calibration Curves of a project are listed within a table.
A single row in this table represents a determined calibration
Curve of a compound.

View Filters
This table contains all View Filters (database filter) within the
project. Using View Filters , the required content, to be displayed
in a table, can be diminished selectively.

38

Project Window Menu Bar

Custom Fields
These are all special and user-defined database fields. With
Custom Fields , individual formulas can be defined for offering
additional calculating options.

Audit Trails
By activating the option Full Audit Trail Support , all changes in a
project will be recorded during the creation of a project. Here,
date, time, user, action and reason for change (if required) are
monitored. The Audit Trail information are listed in the Audit
Trail table.
Single objects in a project are described by an identification number. This means a clear
identification is not given by the name of an object, but by the objects ID. E.g. sample sets
with the same name can be created, but they get a different sample set ID. Therefore, when
reporting results it makes sense to always use the respective object IDs. By this, a traceability is
given for all your data and calculations. IDs are assigned consecutively and are therefore unique
within a project . For this reason, it makes sense to describe the project, where the results have
been processed, in order to provide traceability and transparency to your data. Empower projects
themselves do not get an ID. They can only be described clearly by the full project path, if projects
are never moved in the tree.

3. 8 Project Window Menu Bar

By using the buttons of the icon bar, all relevant applications can
be launched directly from the Project window. The most important buttons of the icon bar are as follows::

39

Data Acquistion

4. DATA ACQUISTION
Connecting to a chromatographic system for instrument control
and data acquisition via Empower you need to open the Run
Samples window.
Run Samples can be launched from the Project window using the button
Should you intend starting data acquisition immediately after login, you can do so by going directly
into the Empower Start window and subsequently clicking on the Run Samples button. Having done
so, you will be prompted, to select not only a chromatographic system but also an Empower project,
where the measured data can be stored.

There are three possible ways to do so, which are as follows:

From the menu bar you can select Tools > Run Samples
With a right mouse click on the project table you can
select Run Samples from the context menu as well
You can choose the respective button in the toolbar. In
case there is more than one system present you will get a
list of all available systems.
Please, select a suitable system and confirm your choice with OK .
The Run Samples window will be displayed.

56

Run Samples Window

4. 1 Run Samples Window
4. 1. 1Overview of the Run Samples Window
From the Run Samples window, data acquisition of single injections, sequences and sample sets can be prepared, started and
monitored. All relevant methods that are required for testing,
can be created in this window. .

The Four Table Views

In the lower left section of the Run Samples window, four different tabs can be selected. Single , Samples , Sample Sets and

Running .

57

Data Acquistion
Single and Samples
Via the tab Single , a single sample can be analyzed. This function
is especially suited for the interactive method creation.
Selecting the tab Samples , a sample table will be provided for
measuring a series of samples as well as a Sample Set .

Sample Sets
The Sample Set table shows the Sample Set Queue . If multiple Sample Sets are to be analyzed after each other, then a list
of those sample sets will be displayed in the right processing
order. The currently running Sample Set becomes red, subsequent
Sample Sets will be displayed in black.

Running
Under the tab named Running you will see a list of injections of
a currently running Sample Set . All the measured samples as well
as the currently running sample are displayed in red characters.
The remaining samples of the run to be measured are displayed
in black. In the Running table, you can alter a currently running Sample Set by a right-click with your mouse, selecting Alter
Running .

Displaying the Chromatographic System

At the bottom left corner of the Run Samples window, the status controls are located. Here, you can control and monitor the
performance of system components such as pump, column temperature, auto-sampler temperature etc. Functionality and the
appearance of the window can strongly vary, depending on the
instrument being controlled and the driver associated.

4. 1. 2Online- Plot
In the Run Samples window, on the right-hand side, appears the
plot of the real-time chromatogram. With your mouse, sections
of the chromatogram can be changed for viewing the chromatogram in more detail (e.g. zoom-in on baseline) whilst a sample
set is running.

58

Run Samples Window

With Empower3 , currently plenty of third party instruments can be controlled, i.e. instruments, where Waters is not the vendor. These instruments are connected to Empower by an own instrument
driver, comparable to printer drivers used by an operating system on your computer. Such a driver
software is developed by the respective instrument vendor, without having any unique guidelines of
how to create such a driver software for Empower. Thus, the composition of instrument methods and
control panels in Run Samples leans on the specific vendor software, for functionality and layout no
unique standard exists.

Because of the high number of currently available instrument drivers and the continuous enhancements for these products a description of drivers that are present on the market when publishing
this manual is neglected. We rather like to refer to the specific vendor documentation that is released for every driver and where functionality and operation should be described sufficiently.

4. 1. 3Most impor tant Instrument Method Setting

Instrument Method- Push Buttons
Here, you have direct access to the Instrument Method , for modification purposes, as well as the initiation of system equilibration.

In case, this toolbar item is not displayed on the Run Samples

screen, it can be faded up using the menu option View > Toolbars
> Instrument Method .

59

Data Processing
5. 5. 4Purity
The Empower function for performing peak purity evaluations is
described in section Peak Purity Control on page 211 in detail.

5. 5. 5PDA Library Search

The Empower function for performing PDA library search is
described in section 5. 11. 8 Spectral Library on page 203 in
detail.

5. 5. 6Components
On the third tab of the Processing Method all information and
definitions are entered for known components. Peak names are
assigned, peak identification criteria are set and calibration settings defined.

The functions of the single fields can be looked up in the table

on the following pages.

Peak identification while retention times are unsteady

At unsteady chromatographic conditions retention times tend to
wander or fluctuate. For compensating this effect Empower offers
the option to update retention times.

136

Integration Method Parameters

You can find the field Update RT on the Components tab of the
Processing Method . Here, you can define how retention times
should be updated. Selecting Replace the present retention time
is simply replaced by the new one. With Average a mean value is
calculated for all previous time values and the current one. The
entries in the Component Table are still kept, whereas the time
values for the calibration curve are updated as well.

Selecting Replace or Average the Unknowns are taken into consideration as well. Here for each
channel, that is processed, a new Calibration ID and a new Cal Curve ID are generated, as for each
retention time update for the calibration curve a new curve is created. However, selecting Replace

Stds or Average Stds IDs are kept for the whole Result Set .

Global Function Components Tab

Average By (None, Amount, Level)

Description
Defines the type of averaging standard injections for creating a calibration curve.

None
Update RT (Never, Replace, Replace
Stds, Average, Average Stds):

Amount

Level

Defines whether retention time values included in the

calibration should be adjusted for changing retention
times. This feature requires a sufficient distance between
the peaks to avoid misassignments.

RT Windows (%)

Defines the retention range in percent of the retention

time of the respective peak.

CCalRef 1

Offers the possibility to define one component of the

Processing Method as reference for interpeak calculations.

This reference can then be referred to in Custom Field
formulas.

RT Reference Used to Name

Unnamed Peaks by RRT

Offers the possibility to name unknown peaks by the relative retention time. For assigning peak names to unknown
peaks in this way only a reference component needs to be
selected here.

137

Data Processing
Assigning Names to Unkown Peaks
In Empower2 , unknown peaks have been listed in the peak table,
but never assigned with a name.
In contrast, Empower3 offers now a function to automatically
assign a name. This name includes the relative retention time
(RRT) of one peak, which can be defined by a reference peak.

As an extension
beyontics offers the

PeakProvider . With
this program, that can
be implemented into

Empower , a special
algorithm calculates
mean values for the
RRT by which peak
names are described. By this the same
components will get
the same peak name
throughout a whole

Sample Set . More

information can be
found at the end of
this manual.

138

It is enough to select one single component to assign the peak

name during the processing of a record (as shown in the above
highlighted entry).

Integration Method Parameters

Please consider:
Always three decimal places are shown.
If variations occur, Empower will assign another peak name. For
example, the same peak can be labelled with RRT 0.517 in one
chromatogram, whereas in another chromatogram it is labelled
with 0.518 .
The RRT values shown in the peak name are not averaged for the
same peak for all injections present in a sample set. Thats why a
harmonisation of the peak name for chemically identical peaks is
not given.

Retention Time Window

Under RT Window % a global setting for the definition of a retention time window can be set. The window is indicated in percent
of the retention time of the respective component. Within this
section a defined component is identified during calibration
and quantification. If a retention time window is necessary that
differs from this global setting, it can be defined directly in the
Component Table for each component individually.

Interpeak Custom Field Calculation with CCalRef1

The Processing Method allows to define components as a variable, that can then be used during Custom Field calculations.
With CCalRef1 a component can be selected that applies as a
reference for the whole chromatogram. Further variables can
be found in the Component Table ( CCompRef1 , CCompRef2 and
CCompRef3 ), that can be used in respect to a specific component.
The fields are useful in order to avoid the explicit naming of a
component in a Custom Field equation. Hence, a much more flexible use of these equations is granted.

Columns of the Component Table

On the following pages a tabular listing of the functionality of
all fields of the Component Table is given.

139

Data Processing
Field Name
Component
Table

Description

Name

Description of the component, name needs to be unique. Spelling must correspond to the entry performed for standard weighings in the Component Editor
( Amounts ).

Component
Type

Category of the component. This field is applies for calculations performed with
the Method Validation Manager and Impurity Processing. More details can be
found in the respective chapter. Selections are defined by Default Strings.

Peak Label

Provides a further description for a component beside the Peak Name .

Retention
Time (min)

Time point after start of the injections in minutes, where the detection of a peak
is expected. Table is sorted by Retention Time. Identical time values can only be
defined, if components are detected in different Channels .

RT Window
(min)

Defines the retention range, where the detection of a component is expected

to be recognized as a named component. The center point of this section is the

Retention Time .
Channel

Possibility to select a Channel Name . Field entry is not required, if evaluated

data only consist of one data channel. If more than one signal is present and
the method should apply to all of them, a channel definition can be performed.
In this case a detection only takes place for the defined channel. If a component supposed to be detected in all channels, an entry is not required. Either a
2D-Channel or a Derived Channel can be selected, as it is defined in the related

Instrument Method or Method Set.

Peak Match
(Closest,
Greatest Area,
Least Area, . )

If more than one peak is detected within a retention window, this field is used

Y Value

Definition how Empower should calculate the Peak Response Value that is used

to define, which of those is to be considered as component. By default the peak

with the closest retention time is used.

for calibration and quantification. One can select between Area , Height , % Area ,

% Height and any Peak Custom Field . Having selected None neither a calibration
nor a quantification takes place for the respective component, but only an identification.

140

Data Processing
5. 5. 7Impurity
Empower3 FR2 offers a new function for automated impurity calculations. For defining the calculations the new Impurity tab is
used in the Processing Method .
2

4
6

A detailed description of the mentioned functions follows in the

next abstracts
1 Impurity Response: Quantity on which the calculation is based on
2 Selection of a Main Component
3 ICH Thresholds: Definition of global threshold values
4 Exclusion of Component Types for the calculation of the Adjusted
Total Area
5 Impurity Groups: Definition of own peak groups based on
Component Types

6 Specified Impurities: Definition of specified threshold values for

named components

144

Integration Method Parameters

Impurity Response
Within the field Impurity Response the user can define the quantity which is used for the impurity calculation; following quantities can be selected by default:
% Adjusted Area
% Area
% Area Against Main Component
% w/w
Amount
Concentration
In addition, all user-defined peak custom fields may be selected
as well.
For % Adjusted Area the selected peak area is calculated relative
to an area sum (given in percent). Custom Fields available within
the project are also offered for selection.
After selecting % w/w , the below located field w Value offers various values for selection:

Choosing % w/w as Impurity Response ends up with a calculation

where the quantity selected in the field w Value is calculated
relative to the same quantity of the selected Main Component .
The result of the calculation is given in percent.
For example, if Height is selected as w Value , the calculation will
be as follows:

Height of each detected peak / height of the main component =

ratio in percent (%)

145

Custom Fields

INDEX

Ascend/Hide 44

Calibrate and Quantitate 165

ASCII 41 , 279 , 285

Calibrate Only 165

Atlas 280

Calibration Curve 177

Audit Trail 39 , 295

Audit Trail Comment 61 , 312

Calibration ID 137

2nd Highest Peak 242

Autofill 85

CCompRef1 139

3D-data 314

Automatically Apply Method Set

CCompRefx 143

Symbols

166

5% Run Time Over Wich to Average

155

Autoscale 242

CCalRef1 137 , 139 , 378

CConst1 bis CConst7 143

Change Project/System 26

% Adjusted Area 145

Auto Ticks 236

Channel 37 , 140

% Highest Peak 242

Available Components 349

Channel Name 140

% of Run Time 157

Average 136

ChemStation 280

Average Detector Drift 158

Abort 93
Abort after Injection is completed
93
Abort after Vial is completed 93
Aborting a Single Injection 70
Abort Now! 93
Abort Options 93
Abort run and continue on next
line 93
Acquisition Client 340
Adjusted Total Area 146 , 147

AIA 41 , 279

Align Controls 254

Allowed Interfaces 335
Allowed User Types 334
Allow Negative Peaks 125 , 130 ,
131
Allow this method to be used in
Sign Off 232
Alternate Units 237
Alter Sample 40 , 41
Always Local Login 335
Annotate Missing Peaks 239
Annotate Unknown Peaks 239
Annotation Tools 300
Apex Detection 129
ApexTrack 122 , 126 , 128 , 130 ,
300 , 310 , 315
Detection Threshold 129
Litoff % 129

Archiving of Projects 289

AreaRatio 177
Ascend 44

386

Average By 137 , 175

Average Detector Noise 157 , 158 ,
160
Average Peak-to-Peak Noise 158 ,
159 , 160

Average Points 175

Average Stds 137
Avocent Box 344
Axis Label 236
Axis Units (XUnits/YUnits) 236

B
Background Processing 286
Background Processing and
Reporting 228
Backup 281
Backup Project Wizard 316
Backup to current project directory 317
Baseline Drift 157
Baseline End Time 155 , 157
Baseline Monitoring 93
Baseline Noise 156 , 157 , 160
Baseline Start Time 155 , 156

Blank 161
Bool 359

Child Projects 322

Chromatogram
Chromatogram Annotation 238
Chromatogram Fraction Regions
238
Chromatogram Properties 234
Chromatogram Properties - Colors
247
Chromatogram Properties - Fonts
247
Chromatogram Properties - Order
By 245
Chromatogram Properties Overlay 238
Chromatogram Properties
Rotation 242
Legend 243
Chromatographic System Properties
348
Citrix 280 , 290
Citrix environment 32
Citrix Terminal Server 19
Clear Calibration 83 , 164
Clone 323
Cloning of Projects 323
Column Properties 262
Compare 40 , 325
Component Field 369

Browse Project 34

Components 136

Component Type 140 , 144 , 146

Calculated 366
Calculate USP, EP and JP s/n 161
Cal Curve ID 137
Calibrate 83 , 135 , 169 , 179

Component Table 137 , 139

COM port 344

Composite Groups 254 , 256

Condition Column 84
Configuration Manager 294

Field Types
Configure DHCP 343

Detector Noise 157 , 160 , 162

Fit (linear, . . .) 141

Configure System 294

Detect Shoulders 130 , 131

Force Baseline by Peak 130

Confirm Identity 298

DHCP 344

Force Baseline by Peak / by Time

Confirm New Password 338

Dilution Factor 41

Contents 33

Dont allow application to stay run-

Continue with next sample 94

ning after logging off 297

125
Force Baseline by Time 130
Force Drop Line 125 , 130

Control Charts 162

Dont allow multiple logons 297

Force Peak 125 , 130

Control Panel 22

Double Peaks 131

Formel Editor 358

Copying of Spectra 290

Drag&Drop 280

Forward Horizontal by Peak 130

Copy&Paste 279

Drawing Objects 255

Forward Horizontal by Peak /

Copy Preferences 306

Driver Software 58

Copy Spectra/Structures 290

Copy to Project 324
Copy to Sub-Projects 315
Create New System 346
Curve Reference 142 , 173
Curves 38
Custom Fields 39 , 314 , 356

126

Forward Horizontal by Time 130

Editing a Sample Set 85

Fractions 38

Electronic Signature 295

Full Audit Trail Support 298

Email 301

Full Lock 322

EMF 41

Full Name 336

Enable ApexTrack Integration 315

Function 69

Enforce Minimum Password Length

of: ... characters 297

Data Acquistion 56
Database 32 , 33 , 287

Forward Horizontal by Time

Enforce Unique User Account Names

296

Gaussian Skim 130 , 131

GC 6890 344

Database Tablespace 314

Enforce Unique User Passwords 296

Global Default User Interface 297

Data Channels 181

Enterprise Edition 18

Global Projects View 324

Data entry required 361

Enum 359

Group Admin 330

Data Filtering Conditions 245

EP s/n 162

Group By 267

Data Types 359

Equilibrate 84

Date Formats 300

Equinox port 344

Default Algorithm 315

Ethernet 343

Header/Footer View 251

Default Amounts 152

Excel 279 , 282 , 285 , 303

Highest Peak 242

Default Individual Report Method

Excluded Component Types 146

229
Default Pk 142
Default Pk End (min) 142
Default Pk Start (min) 142

Exponential Notation 244

Exponential Skim 125 , 130

Default User Interface 335

Export 40 , 41
Export ASCII File 282
Exporting data 278
Export Method 37 , 281
Export to Text 288

Default User Type 333

External 360

Default Strings 140 , 305

Default Units 143

Default Value 361

Delimeters 282
Derived Channel 140 , 181

F
Field Name 244

Descend 44

Field Type 244

Descend/Hide 44

Field Types 359

Detection Threshold 129

Finish an interrupted Sample Set

Detector Drift 158

91

ICH Threshold 144 , 147

Import
Import Function 279
Importing Data 278
Importing Plate Types 280
Impurity
Impurity Group 144 , 147
Impurity Processing 140
Impurity Response 144 , 145
Impurity Type 143
Include Duplicate Results 262
Inhibit Integration 126 , 130
Inject Functions
Inject Controls 82
Inject Immediate Samples 83

387