Methyl Isobutyl Ketone
Methyl Isobutyl Ketone
Methyl Isobutyl Ketone
Used In:
Nitrocellulose lacquers
Advantages:
Zhigang Lei
Jianwei Li
Chengyue Li
Biaohua Chen
column and the other solvent recovery column) were added and some
simplification was made so as to recycle MIBK. In this case
the yield of MIBK was 91.7%. Moreover, about 27.6% water stream per kilogram
MIBK product is saved.
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We claim:
1. A method for producing methyl isobutyl ketone (MIBK) from acetone and
hydrogen, comprising: in a first reaction step, introducing acetone, where at least
a portion of the acetone undergoes a condensation reaction to form diacetone
alcohol (DAA), followed by a dehydration reaction that converts at least a portion
of the DAA to mesityl oxide (MO), in the presence of a suitable catalyst;
controlling the composition of the outlet of the first reaction step such that a
favorable liquid-liquid phase split occurs, producing two liquid phases that can be
subsequently separated in a decanter; in a second reaction step, contacting the
organic phase containing MO with hydrogen, where MO is converted to MIBK in
the presence of a suitable hydrogenation catalyst; and purifying the MIBK-rich
stream from the second reaction step to produce high purity MIBK.
2. The method according to claim 1, where the condensation and dehydration
reaction occurs at a temperature in the range of about 20-120 C. and a pressure
in the range of about 1-3 atm.
3. The method according to claim 1, where the first reaction step is carried out in
more than one reactor stages, with the last reactor stage operated such that a
substantial portion of the DAA formed in the prior reactor stages is converted
back to acetone.
4. The method according to claim 3, where the outlet of the first reaction step is
fed to a separator to remove a substantial portion of acetone, so as to produce a
product stream rich in MO and with a low concentration of acetone and DAA.
5. The method according to claim 4, where the product stream containing MO is
introduced to a decanter where it splits into two liquid phases, and where an MO
rich organic phase is withdrawn from the decanter.
6. The method according to claim 1, where the first reaction step is carried out in
a single reactor stage, such that the product stream from the first reaction step
contains a substantial concentration of DAA.
7. The method according to claim 6, where the outlet of the first reaction step is
fed to a separator to remove a substantial portion of acetone, so as to produce a
product stream rich in MO, and which has a low concentration of acetone.
8. The method according to claim 7 where the product stream has a substantial
concentration of DAA.
9. The method according to claim 7, where an MIBK rich stream is added to the
MO rich product stream, so as to produce a product stream with a low
concentration of DAA.
10. The method according to claim 9, where the product stream containing MO is
introduced to a decanter where it splits into two liquid phases, and where an MO
rich organic phase is withdrawn from the decanter.
11. A system for producing methyl isobutyl ketone (MIBK) from acetone and
hydrogen, comprising: a first reactor, said first reactor configured to receive
acetone, where at least a portion of the acetone undergoes a condensation
reaction to form diacetone alcohol (DAA), followed by a dehydration reaction that
converts at least a portion of the DAA to mesityl oxide (MO), in the presence of a
suitable catalyst; a first separator, said first separator configured to control the
composition of the outlet of the first reactor such that a favorable liquid-liquid
phase split occurs, producing two liquid phases that can be subsequently
separated in a decanter; a second reactor, said second reactor configured to
contact the organic phase containing MO with hydrogen, where MO is converted
to MIBK in the presence of a suitable hydrogenation catalyst; and a second
separator, said second separator configured to purify the MIBK-rich stream from
the second reactor to produce high purity MIBK.
12. The system according to claim 11 further comprising: a decanter, said
decanter configured to separate the two liquid phases produced from the first
separator into the organic phase and an aqueous phase.
13. The system according to claim 11 where the first reactor is comprised of one
or more reactor stages.
14. The system according to claim 11 where the first reactor is comprised of
multiple reactor stages, and where the last reactor stage is configured such that
a substantial portion of the DAA formed in the prior reactor stages is converted
back to acetone.
15. The system according to claim 12 where an MIBK rich stream recovered from
the second separator is added to the decanter.
Description:
RELATED APPLICATIONS
The present application claims the benefit of, and priority to, U.S. Provisional
Patent Application Ser. No. 61/847,507, filed on Jul. 17, 2013, entitled Two-Step
System And Method For The Production Of Methyl Isobutyl Ketone, which is
hereby incorporated by reference in its entirety.
FIELD OF THE INVENTION
The present invention relates to the production of Methyl isobutyl ketone (MIBK)
from acetone and hydrogen. More specifically, the present invention relates to a
method and system for production of MIBK in a two-step reaction process; the
first reaction step performs aldol condensation and dehydration while the second
reaction step performs hydrogenation.
BACKGROUND
Methyl isobutyl ketone (MIBK) is a colorless organic compound with the formula
(CH3)2CHCH2C(O)CH3, which is widely used as an industrial solvent for
nitrocellulose, lacquers, and certain polymers and resins. Another major use is as
and MO and water once, which are both energy intensive. In another
embodiment described in the '328 patent, the first reaction zone is operated so
that substantially all of the acetone is converted, and the product stream
contains at most traces of acetone. To achieve such a high acetone conversion,
the process requires high catalyst loading in the first reaction zone, which is
disadvantageous from the catalyst cost point of view.
Moreover, the process disclosed by the '328 patent uses a catalytic distillation
column operating at total reflux as the first reaction zone, operating at a
temperature of 100-120 C. in the catalyst bed, a temperature of 120-150 C. in
the column reboiler, and a pressure of 2-7 bar. A continuous energy supply is
needed in the reboiler to keep the reaction mixture in a state of boiling.
Moreover, it is known that higher temperatures, such as those used in the '328
patent, promote the formation of heavier condensation products.
It is desirable to have a process which operates at as mild conditions as possible.
Moreover, in order to minimize the energy cost for operating the process, it is
desirable to have a separation sequence in which evaporation of the desired
product or recycled component is minimized. Further developments are needed.
SUMMARY
Accordingly, embodiments of the present invention provides an improved
process for the production of methyl isobutyl ketone (MIBK). In some
embodiments, a method of producing MIBK is provided, comprising: in a first
reaction step, introducing acetone, where at least a portion of the acetone
undergoes a condensation reaction to form diacetone alcohol (DAA), followed by
a dehydration reaction that converts at least a portion of the DAA to mesityl
oxide (MO), in the presence of a suitable catalyst, and at pressures in the range
of 1-3 atm and temperatures in the range of 20-120 C.; controlling the
composition of a product stream after the first reaction step such that a
favorable liquid-liquid phase split can be obtained in a decanter, without reacting
acetone substantially completely and without first removing DAA by separation;
recovering from the decanter, an organic phase rich in MO, and an aqueous
phase not containing a substantial concentration of valuable organic
components; in a second reaction step, contacting the organic phase containing
MO with hydrogen, where MO is converted to MIBK in the presence of a suitable
hydrogenation catalyst; and purifying the MIBK-rich stream from the second
reaction step to produce high purity MIBK. In some embodiments the first
reaction step is carried out in more than one reactor stages, with the last reactor
stage operated such that a substantial portion in the range of more than 50% of
the DAA formed in the prior reactor stages is converted back to acetone. The
outlet of the first reaction step may be fed to a separator to remove a substantial
portion of more than 90% (preferably more than 95%) of acetone, so as to
produce a product stream rich in MO and with a low concentration of acetone
and DAA, the low concentration of acetone being in the range of less than 1% by
weight (preferably less than 0.5% by weight), and the low concentration of DAA
being in the range of less than 5% by weight.
In other embodiments, the first reaction step is carried out in a single reactor
stage, such that the product stream from the first reaction step contains a
substantial concentration of DAA of more than 5% by weight. In some
embodiments the outlet of the first reaction step is fed to a separator to remove
a substantial portion of acetone in the range of more than 90% (preferably more
than 95%), so as to produce a product stream rich in MO, and which has a low
concentration of acetone, the low concentration of acetone being in the range of
less than 1% by weight (preferably less than 0.5% be weight). The product
stream may have a substantial concentration of DAA of more than 10% by
weight. In some embodiments, an MIBK rich stream is added to the MO rich
product stream, so as to produce a product stream with a low concentration of
DAA, the low concentration of DAA being in the range of less than 5% by weight.
In some embodiments, the condensation reaction and dehydration reaction occur
substantially simultaneously in the first reaction step.
In another aspect, embodiments of the present invention provide a system for
producing methyl isobutyl ketone from acetone and hydrogen, comprising: a first
reactor, said first reactor configured to receive acetone, where at least a portion
of the acetone undergoes a condensation reaction to form DAA, followed by a
dehydration reaction that converts at least a portion of the DAA to MO, in the
presence of a suitable catalyst; a first separator, said first separator configured
to control the composition of the outlet of the first reactor such that a favorable
liquid-liquid phase split occurs, producing two liquid phases that can be
subsequently separated in a decanter; a second reactor, said second reactor
configured to contact the organic phase containing MO with hydrogen, where MO
is converted to MIBK in the presence of a suitable hydrogenation catalyst; and a
second separator, said second separator configured to purify the MIBK-rich
stream from the second reactor to produce high purity MIBK. In some
embodiments the first reactor is comprised of multiple reactor stages, and where
the last reactor stage is configured such that a substantial portion of the DAA in
the range of more than 50% formed in the prior reactor stages is converted back
to acetone.
BRIEF DESCRIPTION OF THE DRAWINGS
Other aspects, embodiments and advantages of the invention will become
apparent upon reading of the detailed description of the invention and the
appended claims provided below, and upon reference to the drawings in which:
FIG. 1(a) shows a phase equilibrium diagram for a ternary system of mesityl
oxide, water, and solvent, where the solvent is a mixture of acetone and
diacetone alcohol;
FIG. 1(b) shows a phase equilibrium diagram for a ternary system of methyl
isobutyl ketone, water, and solvent, where the solvent is a mixture of acetone
and diacetone alcohol;
FIG. 1(c) shows a phase equilibrium diagram for a quaternary system of mesityl
oxide, water, solvent, and methyl isobutyl ketone, where the solvent is a mixture
of acetone and diacetone alcohol; and
FIG. 2 shows a simplified flow diagram of a system and method for producing
methyl isobutyl ketone from acetone according to some embodiments of the
present the invention.
DETAILED DESCRIPTION
The present invention relates broadly to the production of methyl isobutyl ketone
(MIBK) from acetone and hydrogen, and in particular to a two-step reaction
system and method wherein a first reaction step performs aldol condensation
and dehydration, and a second reaction step performs hydrogenation to form
MIBK.
In some embodiments, in the first reaction step, acetone is converted to mesityl
oxide (MO) via aldol condensation and dehydration reactions which are
conducted simultaneously in the presence of a catalyst. More particularly, the
catalyst may be an ion exchange resin catalyst such as an Amberlyst
(trademark) resin, a zeolite, or any other suitable catalyst. The main reactions
occurring in the first reaction step can be written as:
2 Acetone
DAA (1)
DAAMO+H2O (2)
The aldol condensation of acetone is known to be limited by equilibrium. The
equilibrium conversion of acetone to diacetone alcohol (DAA) is known to be
around 23% at 0 C. and around 4% at 55 C. The simultaneous dehydration of
DAA to MO shifts the equilibrium of reaction (1) to the right, and enables higher
per pass conversions of acetone to DAA. The first reaction step may be carried
out in a single reactor stage, or in multiple reactor stages, such as by using a
cascade of two of more connected reactors, operating at relatively similar, or
different conditions. The reactor(s) can be of any suitable type known in the art,
and can be operated with the catalyst in suspension, such as in a stirred slurry
reactor, or more typically, with the catalyst packed in a column. Apart from the
reactions listed above there may also be side reactions which produce impurities
such as triacetone alcohol (TAA), trimethylbenzene (TMB), phorone, isophorone,
and other byproducts, so that the outlet stream from the first reaction step
contains unreacted acetone, DAA, MO, water, and the impurities. The proportion
of these components in the outlet stream depends on the operating conditions
such as temperature and pressure used in the first reaction step. Higher
temperatures promote the formation of heavier condensation products, hence
mild conditions are preferred. However, the temperature of the first reaction step
may be chosen in view of the reaction rate required to give reasonable per pass
conversions using economically feasible catalyst amount. Also, the reaction
temperature is related to the pressure, by vapor-liquid equilibrium. Accordingly,
in some embodiments the first reaction step may be operated at a temperature
in the range of about 20 C. to 120 C., and a pressure in the range of about 1
atm to 3 atm. If the first reaction step is carried out using more than one reactor
stage, the operating conditions of each stage may be relatively similar, or
preferably, they may be different, to better regulate the composition of the
product stream.
The composition of the outlet of the first reaction step is controlled such that a
favorable liquid-liquid phase split occurs, producing an aqueous and an organic
liquid phase that are subsequently separated in a decanter. This is achieved by
choosing the operating conditions for the first reaction step and/or by other
This can be achieved by operating the first reaction step at a high conversion of
acetone and DAA, or by separating acetone and DAA from the product of the first
reaction step. For example, U.S. Pat. No. 6,762,328 describes that when the
product stream from the first reaction zone includes DAA, other by-products, and
unreacted acetone, these are removed in a treatment zone. The treatment
process described in the '328 patent involves subjecting the product from the
first reaction zone to a series of distillation operations to remove acetone, DAA,
and heavier impurities so as to give a decanter feed rich in MO. In another
embodiment described in the '328 patent, the first reaction zone is operated so
that substantially all of the acetone is converted, so that the product stream
comprises substantially only MO, DAA and water, with at most traces of residual
acetone. In a variation of the above embodiments, the '328 patent calls for
additionally converting all the DAA to MO, using a zone of temperature and water
resistant acid catalyst near the reboiler of the catalytic distillation unit of the first
reaction zone. However, these methods are disadvantageous from the point of
view of capital and/or energy cost.
According to the present invention, an understanding of the reaction and phase
equilibrium of the system allows a distinct and significantly improved way to
control the composition of the first reaction step so as to produce a favorable
liquid-liquid separation in the decanter, without reacting acetone substantially
completely in the first reaction step, and without separating DAA from the
product mixture or outlet from the first reaction step.
According to one embodiment of the present invention, the first reaction step is
carried out in at least two reactor stages. When two reactor stages are used, the
first reactor stage is responsible for the majority of the conversion of acetone to
DAA and MO. The temperature, pressure, and the catalyst volume provided in the
first reactor stage are chosen in order to achieve a suitable per pass conversion
of acetone, which need not be a substantially complete conversion, but may be
any suitable conversion from about 10% to 100%. Higher temperatures promote
the formation of heavier condensation byproducts, hence mild conditions are
preferred. However, the temperature may be chosen so as to achieve the desired
acetone conversion using an economically feasible volume of catalyst.
Accordingly, the first reaction stage may be operated at a temperature in the
range of about 20 C. to 120 C., preferably in a range of about 20 C. to 100 C.,
and a pressure in the range of about 1 atm to 3 atm. The proportion of acetone
and DAA in the outlet of the first reactor stage depends on the temperature. At
higher temperatures, the equilibrium of reaction (1) is shifted in the direction of
more acetone and less DAA. The second reactor stage is provided to
substantially reduce the proportion of DAA present in the outlet of the first
reactor stage, by converting a large portion of the DAA back to acetone.
Accordingly, the second reactor may operate at a temperature higher than the
first reactor stage, within a range of about 20 C. to 120 C., preferably in a
range of about 50 C. to 120 C. Note that the second reactor stage is not
intended to convert DAA to MO, or to convert additional acetone to DAA. The
catalyst used in the second reactor stage may be the same as that in the first
reactor stage, or it may be a catalyst without the capability of catalyzing the
dehydration of DAA to MO (reaction (2)), such as a basic ion exchange resin
catalyst. The volume of catalyst provided in the second reactor stage is such that
the desired reduction in the concentration of DAA can be attained, as dictated by
Moreover, the tie lines for the MIBK/water/solvent system are such that more of
the solvent (i.e. acetone and DAA) present in the decanter feed is retained within
the organic phase, and less goes to the aqueous phase. This is contrary to the
MO/water/solvent system, where a larger proportion of the DAA and acetone
present in the decanter feed, are lost to the aqueous phase. Thus, adding MIBK
to the decanter feed has a favorable effect on the liquid-liquid separation
process.
Referring specifically to FIG. 1(c), a sketch of the phase diagram of a quaternary
system involving MO, water, solvent, and MIBK is shown. The shaded threedimensional region represents the LLE envelope at a fixed temperature, in which
liquid-liquid phase split will occur. According to the present invention, the size of
the LLE envelope can be controlled by adjusting the concentration ratio of the
two solvent components, in this case acetone and DAA, as well as the operating
temperature of the decanter. Moreover, the position of the feed mixture within
the LLE envelope can be controlled by adjusting the composition of the product
mixture withdrawn from the acetone recovery column, and the amount of MIBK
added to the product mixture.
If the composition of product mixture is located outside the LLE envelope, such
as point M5 in FIG. 1(c) (point M5 is located on the triangular face of the
tetrahedron, with MO, water, and solvent as vertices), MIBK may be added to the
mixture so that the mixture composition moves along line 2in FIG. 1(c) towards
point M6 (located in the interior of the tetrahedron), to produce a suitable
composition inside the LLE envelope. The composition of point M6 in FIG. 1(c) will
split to give an organic stream O6 and an aqueous stream A6 in the decanter.
One exemplary embodiment of a system and method of the present invention is
illustrated in FIG. 2. In general, the system 10 is comprised of a condensation
and dehydration reactor unit 15; a separator unit 20 for removing unreacted
acetone and optionally, heavy impurities; a decanter 25for separating the
aqueous phase from the organic phase; a hydrogenation reactor unit 30; and a
separator unit 35 for recovering high purity MIBK. Fresh acetone feed 30 is
mixed with recycled acetone and DAA, and conveyed to reactor 15 where it is
contacted with a suitable catalyst such that a part of the acetone is converted to
MO via reactions (1) and (2). Reactor 15 may be comprised of one or more
reactor stages. The outlet stream 40 contains unreacted acetone, DAA, MO,
water, and impurities generated from side reactions in reactor 15. Unreacted
acetone is separated in a separator 20 using a suitable method such as
distillation, and returned to the first reactor through line 45. Impurities such as
TAA, TMB, phorone, and isophorone are also optionally separated and purged
through line 42.
In one embodiment of the invention, the reactor 15 is comprised of more than
one reactor stage, such as two reactor stages. The first reactor stage converts a
part of the acetone to MO. The final reactor stage operates at a higher
temperature, and is responsible for converting a significant portion of the DAA
back to acetone. The resulting stream 46 lies within the LLE envelope, and
preferably has a low concentration of acetone and DAA, such that a favorable
liquid-liquid phase split occurs in a decanter 25.
Example 3
Example 3 illustrates one embodiment of the present invention. The first reaction
step is carried out in two reactor stages. The first reactor stage operates at 40
C. and 1 atm. Suitable amount of catalyst is provided to achieve a per pass
acetone conversion of about 54%, which is similar to that in Example 1. An
additional, or second reactor stage, is provided in this embodiment of the
present invention. The second reactor stage is operated at 100 C. and 1 atm,
and is provided with just enough catalyst to convert a significant amount of DAA
back to acetone, as directed by the changed reaction equilibrium at the higher
temperature. The rest of the process flow is similar to that described in Example
1. Due to the conversion of DAA back to acetone in the second reactor stage, the
feed to the decanter is lean in DAA. The resulting loss of DAA to the aqueous
phase is greatly diminished, with an aqueous phase DAA concentration of only
0.6%. This example is contrasted with Example 1 which operates at a similar
acetone conversion, and illustrates the benefit of the present invention. An MO
rich organic phase can be recovered by a liquid-liquid phase split after the first
reaction step, with minimal loss of valuable organics to the aqueous phase,
without having to react acetone substantially completely, and without first
removing DAA by separation.
Example 4
Example 4 uses a process flow and operating conditions identical to that in
Example 3, with the first reaction step operated with two reactor stages. The per
pass acetone conversion is about 28%, which is similar to that in Example 2.
However, in contrast to Example 2, the second reactor stage provided in
Example 4 reduces the DAA concentration in the decanter feed. The
corresponding loss of DAA to the aqueous phase is greatly diminished, with an
aqueous phase DAA concentration of only 0.7%. This is in contrast with the large
loss of DAA in Example 2. Example 4 illustrates that the method of the present
invention can be applied even with a low per pass acetone conversion in the first
reaction step.
Example 5
Example 5 illustrates a second embodiment of the present invention. The first
reaction step operates with only one reactor stage, as in Example 2. After
removing acetone in a distillation column, the product contains a significant
concentration of DAA (18 wt %). This composition is adjusted by mixing an MIBK
rich recycle stream from the downstream process. The resulting product stream
is introduced to a decanter where, due to the presence of MIBK, the valuable
organic components are retained in the organic phase. The loss of DAA to the
aqueous phase is much lower than in Example 2. Again, this example illustrates
a simple process to recover an MO rich organic phase after the first reaction
step, with a minimal loss of valuable organics to the aqueous phase, without
having to react acetone substantially completely, and without first removing DAA
by separation.