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Chapter 08 Electron Beams

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Chapter 8: Electron Beams: Physical

and Clinical Aspects


Set of 91 slides based on the chapter authored by
W. Strydom, W. Parker, and M. Olivares
of the IAEA publication (ISBN 92-0-107304-6):
Radiation Oncology Physics:
A Handbook for Teachers and Students

Objective:
To familiarize the student with the basic principles of radiotherapy
with megavoltage electron beams.
Slide set prepared in 2006
by E.B. Podgorsak (Montreal, McGill University)
Comments to S. Vatnitsky:
dosimetry@iaea.org

Version 2012

IAEA
International Atomic Energy Agency

CHAPTER 8.

8.1.
8.2.
8.3.

TABLE OF CONTENTS

Central axis depth dose distributions in water


Dosimetric parameters of electron beams
Clinical considerations in electron beam therapy

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.1 Slide 1

8.1 CENTRAL AXIS DEPTH DOSE DISTRIBUTIONS

Megavoltage electron beams represent an important


treatment modality in modern radiotherapy, often
providing a unique option in the treatment of superficial
tumours.

Electrons have been used in radiotherapy since the early


1950s.

Modern high-energy linacs typically provide, in addition to


two photon energies, several electron beam energies in
the range from 4 MeV to 25 MeV.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.1 Slide 1

8.1 CENTRAL AXIS DEPTH DOSE DISTRIBUTIONS


8.1.1 General shape of the depth dose curve

The general shape of the central axis depth dose curve


for electron beams differs from that of photon beams.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.1.1 Slide 1

8.1 CENTRAL AXIS DEPTH DOSE DISTRIBUTIONS


8.1.1 General shape of the depth dose curve

Electron beam central axis percentage depth dose curve


exhibits the following characteristics:
Surface dose is relatively high
(of the order of 80 % 100 %).
Maximum dose occurs at a
certain depth referred to as the
depth of dose maximum zmax.
Beyond zmax the dose drops off
rapidly and levels off at a small
low level dose called the
bremsstrahlung tail (of the order
of a few per cent).

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.1.1 Slide 2

8.1 CENTRAL AXIS DEPTH DOSE DISTRIBUTIONS


8.1.1 General shape of the depth dose curve

Electron beams are almost monoenergetic as they leave


the linac accelerating waveguide.
In moving toward the patient through:

Waveguide exit window


Scattering foils
Transmission ionization chamber
Air

and interacting with photon collimators, electron cones


(applicators) and the patient, bremsstrahlung radiation is
produced. This radiation constitutes the bremsstrahlung tail
of the electron beam PDD curve.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.1.1 Slide 3

8.1 CENTRAL AXIS DEPTH DOSE DISTRIBUTIONS


8.1.2 Electron interactions with absorbing medium

As the electrons propagate through an absorbing medium,


they interact with atoms of the absorbing medium by a
variety of elastic or inelastic Coulomb force interactions.

These Coulomb interactions are classified as follows:

Inelastic collisions with orbital electrons of the absorber atoms.


Inelastic collisions with nuclei of the absorber atoms.
Elastic collisions with orbital electrons of the absorber atoms.
Elastic collisions with nuclei of the absorber atoms.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.1.2 Slide 1

8.1 CENTRAL AXIS DEPTH DOSE DISTRIBUTIONS


8.1.2 Electron interactions with absorbing medium

Inelastic collisions between the incident electron and


orbital electrons of absorber atoms result in loss of incident
electrons kinetic energy through ionization and excitation
of absorber atoms (collision or ionization loss).

The absorber atoms can be ionized through two types of


ionization collision:
Hard collision in which the ejected orbital electron gains enough
energy to be able to ionize atoms on its own (these electrons are
called delta rays).
Soft collision in which the ejected orbital electron gains an
insufficient amount of energy to be able to ionize matter on its own.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.1.2 Slide 2

8.1 CENTRAL AXIS DEPTH DOSE DISTRIBUTIONS


8.1.2 Electron interactions with absorbing medium

Elastic collisions between the incident electron and nuclei


of the absorber atoms result in:
Change in direction of motion of the incident electron (elastic
scattering).

A very small energy loss by the incident electron in individual


interaction, just sufficient to produce a deflection of electrons path.

The incident electron loses kinetic energy through a


cumulative action of multiple scattering events, each event
characterized by a small energy loss.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.1.2 Slide 3

8.1 CENTRAL AXIS DEPTH DOSE DISTRIBUTIONS


8.1.2 Electron interactions with absorbing medium

Electrons traversing an absorber lose their kinetic energy


through ionization collisions and radiation collisions.

The rate of energy loss per gram and per cm2 is called the
mass stopping power and it is a sum of two components:
Mass collision stopping power
Mass radiation stopping power

The rate of energy loss for a therapy electron beam in


water and water-like tissues, averaged over the electrons
range, is about 2 MeV/cm.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.1.2 Slide 4

8.1 CENTRAL AXIS DEPTH DOSE DISTRIBUTIONS


8.1.3 Inverse square law (virtual source position)

In contrast to a photon beam,


which has a distinct focus located
at the accelerator x ray target, an
electron beam appears to originate
from a point in space that does not
coincide with the scattering foil or
the accelerator exit window.

The term virtual source position


was introduced to indicate the
virtual location of the electron
source.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.1.3 Slide 1

8.1 CENTRAL AXIS DEPTH DOSE DISTRIBUTIONS


8.1.3 Inverse square law (virtual source position)

Effective source-surface distance SSDeff is defined as the


distance from the virtual source position to the edge of the
electron cone applicator.

The inverse square law may be used for small SSD


differences from the nominal SSD to make corrections to
absorbed dose rate at zmax in the patient for variations in
air gaps g between the actual patient surface and the
nominal SSD.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.1.3 Slide 2

8.1 CENTRAL AXIS DEPTH DOSE DISTRIBUTIONS


8.1.3 Inverse square law (virtual source position)

A common method for determining SSDeff consists of


measuring the dose rate at zmax in phantom for various air
gaps g starting with Dmax (g 0) at the electron cone.
The following inverse square law relationship holds:
Dmax (g 0) SSDeff zmax g

SSD

z
Dmax (g )
eff
max

The measured slope of the linear plot is:

1
SSDeff zmax

The effective SSD is then calculated from: SSDeff

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1
zmax
k

Radiation Oncology Physics: A Handbook for Teachers and Students - 8.1.3 Slide 3

8.1 CENTRAL AXIS DEPTH DOSE DISTRIBUTIONS


8.1.3 Inverse square law (virtual source position)

Typical example of data measured in determination of


virtual source position SSDeff normalized to the edge of the
electron applicator (cone).

SSDeff

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1
zmax
k

Radiation Oncology Physics: A Handbook for Teachers and Students - 8.1.3 Slide 4

8.1 CENTRAL AXIS DEPTH DOSE DISTRIBUTIONS


8.1.3 Inverse square law (virtual source position)

For practical reasons the nominal SSD is usually a fixed


distance (e.g., 5 cm) from the distal edge of the electron
cone (applicator) and coincides with the linac isocentre.

Although the effective SSD (i.e., the virtual electron source


position) is determined from measurements at zmax in a
phantom, its value does not change with change in the
depth of measurement.

The effective SSD depends on electron beam energy and


must be measured for all energies available in the clinic.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.1.3 Slide 5

8.1 CENTRAL AXIS DEPTH DOSE DISTRIBUTIONS


8.1.4 Range concept

By virtue of being surrounded by a Coulomb force field,


charged particles, as they penetrate into an absorber
encounter numerous Coulomb interactions with orbital
electrons and nuclei of the absorber atoms.

Eventually, a charged particle will lose all of its kinetic


energy and come to rest at a certain depth in the
absorbing medium called the particle range.

Since the stopping of particles in an absorber is a


statistical process several definitions of the range are
possible.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.1.4 Slide 1

8.1 CENTRAL AXIS DEPTH DOSE DISTRIBUTIONS


8.1.4 Range concept

Definitions of particle range: (1) CSDA range


In most encounters between the charged particle and absorber
atoms the energy loss by the charged particle is minute so that it
is convenient to think of the charged particle as losing its kinetic
energy gradually and continuously in a process referred to as the
continuous slowing down approximation (CSDA - Berger and
Seltzer).
The CSDA range or the mean path length of an electron of initial
kinetic energy E0 can be found by integrating the reciprocal of the
total mass stopping power over the energy from E0 to 0:

RCSDA

E0

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S (E )
dE

Radiation Oncology Physics: A Handbook for Teachers and Students - 8.1.4 Slide 2

8.1 CENTRAL AXIS DEPTH DOSE DISTRIBUTIONS


8.1.4 Range concept

CSDA ranges for electrons in air and water


Electron
energy
(MeV)

CSDA
range
in air
(g/cm2)

6
7
8
9
10
20
30

3.255
3.756
4.246
4.724
5.192
9.447
13.150

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CSDA
range
in water
(g/cm2)

3.052
3.545
4.030
4.506
4.975
9.320
13.170

The CSDA range is a calculated


quantity that represents the
mean path length along the
electrons trajectory.
The CSDA range is not the the
depth of penetration along a
defined direction.

Radiation Oncology Physics: A Handbook for Teachers and Students - 8.1.4 Slide 3

8.1 CENTRAL AXIS DEPTH DOSE DISTRIBUTIONS


8.1.4 Range concept

Several other range definitions are in use for electron beams:

Maximum range Rmax


Practical range Rp
Therapeutic range R90
Therapeutic range R80
Depth R50
Depth Rq

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.1.4 Slide 4

8.1 CENTRAL AXIS DEPTH DOSE DISTRIBUTIONS


8.1.4 Range concept

Maximum range Rmax is defined


as the depth at which the
extrapolation of the tail of the
central axis depth dose curve
meets the bremsstrahlung
background.
Rmax is the largest penetration
depth of electrons in absorbing
medium.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.1.4 Slide 5

8.1 CENTRAL AXIS DEPTH DOSE DISTRIBUTIONS


8.1.4 Range concept

Practical range Rp is defined


as the depth at which the
tangent plotted through the
steepest section of the
electron depth dose curve
intersects with the
extrapolation line of the
bremsstrahlung tail.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.1.4 Slide 6

8.1 CENTRAL AXIS DEPTH DOSE DISTRIBUTIONS


8.1.4 Range concept

Depths R90, R80, and R50 are


defined as depths on the
electron PDD curve at which
the PDDs beyond the depth
of dose maximum zmax attain
values of 90 %, 80 %, and
50 %, respectively.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.1.4 Slide 7

8.1 CENTRAL AXIS DEPTH DOSE DISTRIBUTIONS


8.1.4 Range concept

Depth Rq is defined
as the depth where
the tangent through
the dose inflection point
intersects the maximum
dose level.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.1.4 Slide 8

8.1 CENTRAL AXIS DEPTH DOSE DISTRIBUTIONS


8.1.5 Buildup region

Buildup region for electron beams, like


for photon beams, is the depth region
between the phantom surface and the
depth of dose maximum zmax.

Surface dose for megavoltage electron


beams is relatively large (typically
between 75 % and 95 %) in contrast to
the surface dose for megavoltage photon
beams which is of the order of 10 % to
25 %.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.1.5 Slide 1

8.1 CENTRAL AXIS DEPTH DOSE DISTRIBUTIONS


8.1.5 Buildup region

Unlike in photon beams, the


percentage surface dose in
electron beams increases
with increasing energy.

In contrast to photon beams,


zmax in electron beams does
not follow a specific trend
with electron beam energy;
it is a result of machine
design and accessories used.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.1.5 Slide 2

8.1 CENTRAL AXIS DEPTH DOSE DISTRIBUTIONS


8.1.6 Dose distribution beyond zmax

Dose beyond zmax, especially at relatively low


megavoltage electron beam energies, drops off sharply as
a result of the scattering and continuous energy loss by
the incident electrons.

As a result of bremsstrahlung energy loss by the incident


electrons in the head of the linac, air and the patient, the
depth dose curve beyond the range of electrons is
attributed to the bremsstrahlung photons.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.1.6 Slide 1

8.1 CENTRAL AXIS DEPTH DOSE DISTRIBUTIONS


8.1.6 Dose distribution beyond zmax

Bremsstrahlung contamination of electron beams depends


on electron beam energy and is typically:
Less than 1 % for
4 MeV electron beams.

Less than 2.5 % for


10 MeV electron beams.

Less than 4 % for


20 MeV electron beams.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.1.6 Slide 2

8.1 CENTRAL AXIS DEPTH DOSE DISTRIBUTIONS


8.1.6 Dose distribution beyond zmax

Electron dose gradient G


is defined as follows:
G

Rp
Rp Rq

Dose gradient G for lower


electron beam energies is
steeper than that for higher
electron energies.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.1.6 Slide 3

8.2 DOSIMETRIC PARAMETERS OF ELECTRON BEAMS


8.2.1 Electron beam energy specification

Spectrum of the electron beam is very complex and is


influenced by the medium the beam traverses.
Just before exiting the waveguide through the beryllium exit
window the electron beam is almost monoenergetic.

The electron energy is degraded randomly when electrons pass


through the exit window, scattering foil, transmission ionization
chamber and air. This results in a relatively broad spectrum of
electron energies on the patient surface.

As the electrons penetrate into tissue, their spectrum is


broadened and degraded further in energy.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.2.1 Slide 1

8.2 DOSIMETRIC PARAMETERS OF ELECTRON BEAMS


8.2.1 Electron beam energy specification

Spectrum of the electron beam depends on the point of


measurement in the beam.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.2.1 Slide 2

8.2 DOSIMETRIC PARAMETERS OF ELECTRON BEAMS


8.2.1 Electron beam energy specification

Several parameters are used for describing the beam


quality of an electron beam:
Most probable energy EKp (0) of the electron beam on phantom
surface.

Mean energy EK (0) of the electron beam on the phantom surface.

Half-value depth R50 on the percentage depth dose curve of the


electron beam.

Practical range Rp of the electron beam.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.2.1 Slide 3

8.2 DOSIMETRIC PARAMETERS OF ELECTRON BEAMS


8.2.1 Electron beam energy specification

The most probable energy EKp (0) on the phantom surface


is defined by the position of the spectral peak.

EKp (0) is related to the practical range Rp (in cm) of the


electron beam through the following polynomial equation:
EKp (0) C1 C2Rp C3Rp2

For water: C1 0.22 MeV


C 2 1.98 MeV/cm
C3 0.0025 MeV/cm2

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.2.1 Slide 4

8.2 DOSIMETRIC PARAMETERS OF ELECTRON BEAMS


8.2.1 Electron beam energy specification

The mean electron energy EK (0) of the electron beam on

the phantom surface is slightly smaller than the most


probable energy EKp (0) on the phantom surface as a result
of an asymmetrical shape of the electron spectrum.

The mean electron energy EK (0) is


related to the half-value depth R50 as:
EK (0) CR50

The constant C for water is 2.33 MeV/cm.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.2.1 Slide 5

8.2 DOSIMETRIC PARAMETERS OF ELECTRON BEAMS


8.2.1 Electron beam energy specification

Harder has shown that the most probable energy EKp (z)
and the mean energy E(z) of the electron beam at a
depth z in the phantom or patient decrease linearly with z.

Harders relationships are expressed as follows:

z
E ( z ) E (0) 1
Rp
p
K

Note:

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p
K

and

z
E ( z ) E (0) 1

Rp

EKp (z 0) EKp (0)

E(z 0) E(0)

EKp (z Rp ) 0

E(z Rp ) 0

Radiation Oncology Physics: A Handbook for Teachers and Students - 8.2.1 Slide 6

8.2 DOSIMETRIC PARAMETERS OF ELECTRON BEAMS


8.2.2 Typical depth dose parameters as a function of energy

Typical electron beam depth dose parameters that should


be measured for each clinical electron beam
Energy
(MeV)

R90
(cm)

R80
(cm)

R50
(cm)

Rp
(cm)

E(0)
(MeV)

Surface
dose %

1.7

1.8

2.2

2.9

5.6

81

2.4

2.6

3.0

4.0

7.2

83

10

3.1

3.3

3.9

4.8

9.2

86

12

3.7

4.1

4.8

6.0

11.3

90

15

4.7

5.2

6.1

7.5

14.0

92

18

5.5

5.9

7.3

9.1

17.4

96

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.2.2 Slide 1

8.2 DOSIMETRIC PARAMETERS OF ELECTRON BEAMS


8.2.3 Percentage depth dose

Similarly to PDDs for photon beams, the PDDs for


electron beams, at a given source-surface distance SSD,
depend upon:
Depth z in phantom (patient).
Electron beam kinetic energy
EK(0) on phantom surface.

Field size A on phantom


surface.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.2.3 Slide 1

8.2 DOSIMETRIC PARAMETERS OF ELECTRON BEAMS


8.2.3 Percentage depth dose

PDDs of electron beams are measured with:


Cylindrical, small-volume ionization chamber in water phantom.
Diode detector in water phantom.

Parallel-plate ionization chamber in water phantom.


Radiographic or radiochromic film in solid water phantom.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.2.3 Slide 2

8.2 DOSIMETRIC PARAMETERS OF ELECTRON BEAMS


8.2.3 Percentage depth dose

Measurement of electron beam PDDs:


If ionization chamber is used, the measured depth ionization
distribution must be converted into a depth dose distribution by
using the appropriate stopping power ratios, water to air, at depths
in phantom.

If diode is used, the diode ionization signal represents the dose


directly, because the stopping power ratio, water to silicon, is
essentially independent of electron energy and hence depth.

If film is used, the characteristic curve (H and D curve) for the


given film should be used to determine the dose against the film
density.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.2.3 Slide 3

8.2 DOSIMETRIC PARAMETERS OF ELECTRON BEAMS


8.2.3 Percentage depth dose

Dependence of PDDs on electron beam field size.

For relatively large field sizes the PDD distribution at a


given electron beam energy is essentially independent of
field size.

When the side of the electron field is smaller than the


practical range Rp, lateral electronic equilibrium will not
exist on the beam central axis and both the PDDs as well
as the output factors exhibit a significant dependence on
field size.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.2.3 Slide 4

8.2 DOSIMETRIC PARAMETERS OF ELECTRON BEAMS


8.2.3 Percentage depth dose

PDDs for small electron fields


For a decreasing field size,
when the side of the field
decreases to below the Rp
value for a given electron
energy:

Depth dose maximum


decreases.
Surface dose increases.
Rp remains essentially
constant, except when the field
size becomes very small.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.2.3 Slide 5

8.2 DOSIMETRIC PARAMETERS OF ELECTRON BEAMS


8.2.3 Percentage depth dose

PDDs for oblique incidence.

Angle of obliquity is defined as the angle between the


electron beam central axis and the normal to the
phantom or patient surface. Angle 0 corresponds to
normal beam incidence.

For oblique beam incidences, especially at large angles


the PDD characteristics of electron beams deviate
significantly from those for normal beam incidence.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.2.3 Slide 6

8.2 DOSIMETRIC PARAMETERS OF ELECTRON BEAMS


8.2.3 Percentage depth dose

Percentage depth dose for oblique beam incidence

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.2.3 Slide 7

8.2 DOSIMETRIC PARAMETERS OF ELECTRON BEAMS


8.2.3 Percentage depth dose

Depth dose for oblique beam incidence

Obliquity effect becomes significant for angles of


incidence exceeding 45o.
Obliquity factor OF( ,z) accounts for the change in depth
dose at a given depth z in phantom and is normalized to
0
1.00 at zmax at normal incidence
.

Obliquity factor at zmax is larger than 1 (see insets on


previous slide).

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.2.3 Slide 8

8.2 DOSIMETRIC PARAMETERS OF ELECTRON BEAMS


8.2.4 Output factors

The output factor for a given electron energy and field


size (delineated by applicator or cone) is defined as the
ratio of the dose for the specific field size (applicator) to
the dose for a 1010 cm2 reference field size
(applicator), both measured at depth zmax on the beam
central axis in phantom at a nominal SSD of 100 cm.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.2.4 Slide 1

8.2 DOSIMETRIC PARAMETERS OF ELECTRON BEAMS


8.2.4 Output factors

When using electron beams


from a linac, the photon
collimator must be opened to
the appropriate setting for a
given electron applicator.

Typical electron applicator


sizes at nominal SSD are:
Circular with diameter: 5 cm
Square: 10x10 cm2; 1515 cm2;
2020 cm2; and 2525 cm2.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.2.4 Slide 2

8.2 DOSIMETRIC PARAMETERS OF ELECTRON BEAMS


8.2.4 Output factors

Often collimating blocks made of lead or a low melting


point alloy (e.g., Cerrobend) are used for field shaping.
These blocks are attached to the end of the electron cone
(applicator) and produce the required irregular field.

Output factors, normalized to the standard 1010 cm2


electron cone, must be measured for all custom-made
irregular fields.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.2.4 Slide 3

8.2 DOSIMETRIC PARAMETERS OF ELECTRON BEAMS


8.2.4 Output factors

For small irregular field sizes the extra shielding affects


not only the output factors but also the PDD distribution
because of the lack of lateral scatter.

For custom-made small fields, in addition to output


factors, the full electron beam PDD distribution should be
measured.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.2.4 Slide 4

8.2 DOSIMETRIC PARAMETERS OF ELECTRON BEAMS


8.2.5 Therapeutic range

Depth of the 90 % dose level on the beam central axis


(R90) beyond zmax is defined as the therapeutic range for
electron beam therapy.

R90 is approximately equal to EK/4 in cm of water, where


EK is the nominal kinetic energy in MeV of the electron
beam.

R80, the depth that corresponds to the 80 % PDD beyond


zmax, may also be used as the therapeutic range and is
approximated by EK/3 in cm of water.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.2.5 Slide 1

8.2 DOSIMETRIC PARAMETERS OF ELECTRON BEAMS


8.2.6 Profiles and off-axis ratio

A dose profile represents a


plot of dose at a given
depth in phantom against
the distance from the
beam central axis.

Profile is measured in a
plane perpendicular to the
beam central axis at a
given depth z in phantom.
Dose profile measured at a depth
of dose maximum zmax in water for
a 12 MeV electron beam and
2525 cm2 applicator cone.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.2.6 Slide 1

8.2 DOSIMETRIC PARAMETERS OF ELECTRON BEAMS


8.2.6 Profiles and off-axis ratio

Two different normalizations are used for beam profiles:


The profile data for a given depth in phantom may be normalized
to the dose at zmax on the central axis (point P). The dose value
on the beam central axis for z zmax then represents the central
axis PDD value.

The profile data for a given depth in phantom may also be


normalized to the value on the beam central axis (point Q). The
values off the central axis for z zmax are then referred to as the
off-axis ratios (OARs).

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.2.6 Slide 2

8.2 DOSIMETRIC PARAMETERS OF ELECTRON BEAMS


8.2.7 Flatness and symmetry

According to the International


Electrotechnical Commission (IEC)
the specification for beam flatness of
electron beams is given for zmax
under two conditions:
Distance between the 90 % dose
level and the geometrical beam
edge should not exceed 10 mm
along major field axes and 20 mm
along diagonals.

Maximum value of the absorbed


dose anywhere within the region
bounded by the 90 % isodose
contour should not exceed 1.05
times the absorbed dose on the
axis of the beam at the same depth.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.2.7 Slide 1

8.2 DOSIMETRIC PARAMETERS OF ELECTRON BEAMS


8.2.7 Flatness and symmetry

According to the International Electrotechnical Commission (IEC)


the specification for symmetry of electron beams requires that the
cross-beam profile measured at depth zmax should not differ by
more than 3 % for any pair of symmetric points with respect to the
central ray.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.2.7 Slide 2

8.3 CLINICAL CONSIDERATIONS


8.3.1 Dose specification and reporting

Electron beam therapy is usually applied in treatment of


superficial or subcutaneous disease.

Treatment is usually delivered with a single direct electron


field at a nominal SSD of 100 cm.

The dose is usually prescribed at a depth that lies at, or


beyond, the distal margin of the target.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.1 Slide 1

8.3 CLINICAL CONSIDERATIONS


8.3.1 Dose specification and reporting

To maximize healthy tissue sparing beyond the tumour


and to provide relatively homogeneous target coverage
treatments are usually prescribed at zmax, R90, or R80.

If the treatment dose is specified at R80 or R90, the skin


dose may exceed the prescription dose.

Since the maximum dose in the target may exceed the


prescribed dose by up to 20 %, the maximum dose should
be reported for all electron beam treatments.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.1 Slide 2

8.3 CLINICAL CONSIDERATIONS


8.3.2 Small field sizes

The PDD curves for electron beams do not depend on field


size, except for small fields where the side of the field is
smaller than the practical range of the electron beam.

When lateral scatter equilibrium


is not reached at small electron
fields:
Dose rate at zmax decreases
Depth of maximum dose, zmax,
moves closer to the surface
PDD curve becomes less steep,

in comparison to a 1010 cm2


field.
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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.2 Slide 1

8.3 CLINICAL CONSIDERATIONS


8.3.3 Isodose distributions

Isodose curves are lines


connecting points of equal
dose in the irradiated
medium.

Isodose curves are usually


drawn at regular intervals
of absorbed dose and are
expressed as a percentage
of the dose at a reference
point, which is usually
taken as the zmax point on
the beam central axis.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.3 Slide 1

8.3 CLINICAL CONSIDERATIONS


8.3.3 Isodose distributions

As electron beam penetrates a


medium (absorber), the beam
expands rapidly below the
surface because of electron
scattering on absorber atoms.

The spread of the isodose


curves varies depending on:

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Isodose level.
Energy of the beam.
Field size.
Beam collimation.

Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.3 Slide 2

8.3 CLINICAL CONSIDERATIONS


8.3.3 Isodose distributions

A particular characteristic of
electron beam isodose curves
is the bulging out of the low
value isodose curves (<20 %)
as a direct result of the
increase in electron scattering
angle with decreasing electron
energy.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.3 Slide 3

8.3 CLINICAL CONSIDERATIONS


8.3.3 Isodose distributions

At energies above 15 MeV


electron beams exhibit a lateral
constriction of the higher value
isodose curves (>80 %). The
higher is the electron beam
energy, the more pronounced
is the effect.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.3 Slide 4

8.3 CLINICAL CONSIDERATIONS


8.3.3 Isodose distributions

The term penumbra generally defines the region at the


edge of the radiation beam over which the dose rate
changes rapidly as a function of distance from the beam
central axis.

The physical penumbra of an electron beam may be


defined as the distance between two specified isodose
curves at a specified depth in phantom.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.3 Slide 5

8.3 CLINICAL CONSIDERATIONS


8.3.3 Isodose distributions

In determination of the
physical penumbra of an
electron beam the ICRU
recommends that:
The 80 % and 20 % isodose
curves be used.

The specified depth of


measurement be R85/2, where
R85 is the depth of the 85 %
dose level beyond zmax on the
electron beam central ray.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.3 Slide 6

8.3 CLINICAL CONSIDERATIONS


8.3.3 Isodose distributions

In electron beam therapy, the air gap is defined as the


separation between the patient and the end of the
applicator cone. The standard air gap is 5 cm.

With increasing air gap:


Low value isodose curves diverge.
High value isodose curves converge toward the central axis of the
beam.

Physical penumbra increases.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.3 Slide 7

8.3 CLINICAL CONSIDERATIONS


8.3.4 Field shaping

To achieve a more customized electron field shape, a lead


or metal alloy cut-out may be constructed and placed on
the applicator as close to the patient as possible.

Field shapes may be determined from conventional or


virtual simulation, but are most often prescribed clinically
by a physician prior to the first treatment.

As a rule of thumb, divide the practical range Rp by 10 to


obtain the approximate thickness of lead required for
shielding (<5 %).

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.4 Slide 1

8.3 CLINICAL CONSIDERATIONS


8.3.4 Field shaping

For certain treatments, such as treatments of the lip,


buccal mucosa, eyelids or ear lobes, it may be
advantageous to use an internal shield to protect the
normal structures beyond the target volume.

Internal shields are usually coated with low atomic number


materials to minimize the electron backscattering into
healthy tissue above the shield.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.4 Slide 2

8.3 CLINICAL CONSIDERATIONS


8.3.4 Field shaping

Extended SSDs have various effects on electron beam


parameters and are generally not advisable.

In comparison with treatment at nominal SSD of 100 cm at


extended SSD:
Output is significantly lower
Beam penumbra is larger
PDD distribution changes minimally.

An effective SSD based on the virtual source position is


used when applying the inverse square law to correct the
beam output at zmax for extended SSD.
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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.4 Slide 3

8.3 CLINICAL CONSIDERATIONS


8.3.5 Irregular surface correction

Uneven air gaps as a result of curved patient surfaces are


often present in clinical use of electron beam therapy.

Inverse square law corrections can be made to the dose


distribution to account for the sloping surface.
D(SSDeff g, z )
SSDeff z
Do (SSDeff , z )

SSD

z
)
eff

From F.M. Khan:


The Physics of
Radiation Therapy

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g = air gap
z = depth below surface
SSDeff = distance between the
virtual source and surface

Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.5 Slide 1

8.3 CLINICAL CONSIDERATIONS


8.3.5 Irregular surface correction

Inverse square correction alone does not account for


changes in side scatter as a result of beam obliquity which:
Increases side scatter at the depth of maximum dose, zmax
Shifts zmax toward the surface
Decreases the therapeutic depths R90 and R80.
D(SSDeff g, z )
2

SSDeff z
Do (SSDeff , z )
OF( , z )
SSDeff g z )

From F.M. Khan:


The Physics of
Radiation Therapy

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OF(z, ) = obliquity factor which


accounts for the change in depth
dose at a point in phantom at depth z
for a given angle of obliquity but
same SSDeff as for 0
Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.5 Slide 2

8.3 CLINICAL CONSIDERATIONS


8.3.6 Bolus

Bolus made of tissue equivalent material, such as wax, is


often used in electron beam therapy:

To increase the surface dose.


To shorten the range of a given electron beam in the patient.
To flatten out irregular surfaces.
To reduce the electron beam penetration in some parts of the
treatment field.

Although labour intensive, the use of bolus in electron


beam therapy is very practical, since treatment planning
software for electron beams is limited and empirical data
are normally collected only for standard beam geometries.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.6 Slide 1

8.3 CLINICAL CONSIDERATIONS


8.3.6 Bolus

The use of computed tomography (CT) for treatment


planning enables accurate determination of tumour shape
and patient contour.
If a wax bolus is constructed such that the total distance
from the bolus surface to the required treatment depth is
constant along the length of
the tumour, then the shape
of the resulting isodose
curves will approximate
the shape of the tumour
as determined with
CT scanning.
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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.6 Slide 2

8.3 CLINICAL CONSIDERATIONS


8.3.7 Inhomogeneity corrections

The dose distribution from an electron beam can be


greatly affected by the presence of tissue inhomogeneities
(heterogeneities) such as lung or bone.

The dose inside an inhomogeneity is difficult to calculate


or measure, but the effect of an inhomogeneity on the
dose beyond the inhomogeneity is relatively simple to
measure and quantify.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.7 Slide 1

8.3 CLINICAL CONSIDERATIONS


8.3.7 Inhomogeneity corrections

The simplest correction for a tissue inhomogeneity


involves the scaling of the inhomogeneity thickness by
its electron density relative to that of water and the
determination of the coefficient of equivalent thickness
(CET).

Electron density of an inhomogeneity is essentially


equivalent to the mass density of the inhomogeneity.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.7 Slide 2

8.3 CLINICAL CONSIDERATIONS


8.3.7 Inhomogeneity corrections

CET is used to determine the effective depth in water


equivalent tissue zeff through the following expression:
zeff z t(1 CET)

z = actual depth of the point of interest


in the patient
t = thickness of the inhomogeneity

For example:

Lung has approximate density of 0.25 g/cm3 and a CET of 0.25.


A thickness of 1 cm of lung is equivalent to 0.25 cm of tissue.
Solid bone has approximate density of 1.6 g/cm3 and a CET of 1.6.
A thickness of 1 cm of bone is equivalent to 1.6 cm of tissue.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.7 Slide 3

8.3 CLINICAL CONSIDERATIONS


8.3.7 Inhomogeneity corrections

Effect of lung inhomogeneity on the PDD distribution of an


electron beam (energy: 15 MeV, field: 1010 cm2).

Thickness t of lung
inhomogeneity: 6 cm
Tissue equivalent thickness:
zeff = 1.5 cm

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.7 Slide 4

8.3 CLINICAL CONSIDERATIONS


8.3.7 Inhomogeneity corrections

If an electron beam strikes the interface between two


materials either tangentially or at a large oblique angle, the
resulting scatter perturbation will affect the dose
distribution at the interface.

Lower density material will receive a higher dose, due to


the increased scattering of electrons from the higher
density side.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.7 Slide 5

8.3 CLINICAL CONSIDERATIONS


8.3.7 Inhomogeneity corrections

Edge effects need to be considered in the following


situations:
Inside a patient, at the interfaces between internal structures of
different density.

On the surface of a patient, in regions of sharp surface irregularity.


On the interface between lead shielding and the surface of the
patient, if the shielding is placed superficially on the patient or if it is
internal shielding.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.7 Slide 6

8.3 CLINICAL CONSIDERATIONS


8.3.8 Electron beam combinations

Occasionally, the need arises to abut electron fields. When


abutting two electron fields, it is important to take into
consideration the dosimetric characteristics of electron
beams at depth in the patient.

The large penumbra and bulging isodose lines produce hot


spots and cold spots inside the target volume.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.8 Slide 1

8.3 CLINICAL CONSIDERATIONS


8.3.8 Electron beam combinations

In general, it is best to avoid using adjacent electron fields.


If the use of abutting fields is absolutely necessary, the
following conditions apply:
Contiguous electron beams should be parallel to one another in
order to avoid significant overlapping of the high value isodose
curves at depth in the patient.

Some basic film dosimetry should be carried out at the junction of


the fields to ensure that no significant hot or cold spots in dose
occur.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.8 Slide 2

8.3 CLINICAL CONSIDERATIONS


8.3.8 Electron beam combinations

Electron - photon field matching is easier than electron electron field matching.

A distribution for photon fields is readily available from a


treatment planning system (TPS) and the location of the
electron beam treatment field as well as the associated hot
and cold spots can be determined relative to the photon
field treatment plan.

Matching of electron and photon fields on the skin will


produce a hot spot on the photon side of the treatment.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.8 Slide 3

8.3 CLINICAL CONSIDERATIONS


8.3.9 Electron arc therapy

Electron arc therapy is a special radiotherapeutic


treatment technique in which a rotational electron beam
is used to treat superficial tumour volumes that follow
curved surfaces.

While its usefulness in treatment of certain large


superficial tumours is well recognized, the technique is
not widely used because it is relatively complicated and
cumbersome, and its physical characteristics are poorly
understood.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.9 Slide 1

8.3 CLINICAL CONSIDERATIONS


8.3.9 Electron arc therapy

The dose distribution in the target volume for electron


arc therapy depends in a complicated fashion on:

Electron beam energy


Field width w
Depth of the isocentre di
Source-axis distance f
Patient curvature
Tertiary collimation
Field shape as defined by the secondary collimator

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.9 Slide 2

8.3 CLINICAL CONSIDERATIONS


8.3.9 Electron arc therapy

Two approaches to electron arc therapy have been


developed:
Electron pseudo-arc based on a series of overlapping stationary
electron fields.
Continuous electron arc using a continuous rotating electron beam.

Calculation of dose distributions in electron arc therapy is a


complicated procedure that generally cannot be performed
reliably with the algorithms used for standard electron beam
treatment planning.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.9 Slide 3

8.3 CLINICAL CONSIDERATIONS


8.3.9 Electron arc therapy

Characteristic angle concept represents a semiempirical technique for treatment planning in electron
arc therapy.
Characteristic angle for an
arbitrary point A on the patient
surface is measured between
the central axes of two rotational
electron beams positioned in
such a way that at point A the
frontal edge of one beam
crosses the trailing edge of the
other beam.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.9 Slide 4

8.3 CLINICAL CONSIDERATIONS


8.3.9 Electron arc therapy

Characteristic angle represents a continuous rotation


in which a surface point A receives a contribution from all ray
lines of the electron beam starting with the frontal edge and
finishing with the trailing edge of the rotating electron beam.
w is the nominal field size.
f is the virtual source isocentre distance.
di is the isocentre depth.

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2di sin

di

1 cos
f
2

Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.9 Slide 5

8.3 CLINICAL CONSIDERATIONS


8.3.9 Electron arc therapy

Characteristic angle is uniquely determined by three


treatment parameters
Source-axis distance f
Depth of isocentre di
Field width w

2di sin
1

di

cos
f
2

Electron beams with combinations of di and w that give


the same characteristic angle exhibit very similar radial
percentage depth dose distributions even though they
may differ considerably in individual di and w.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.9 Slide 6

8.3 CLINICAL CONSIDERATIONS


8.3.9 Electron arc therapy

PDDs for rotational electron


beams depend only on:
Electron beam energy.
Characteristic angle .

When a certain PDD is required


for patient treatment one may
choose a that will give the
required beam characteristics.
Since di is fixed by the patient
contour, the required is
obtained by choosing the
appropriate w.
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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.9 Slide 7

8.3 CLINICAL CONSIDERATIONS


8.3.9 Electron arc therapy

Photon contamination of the electron beam is of concern


in electron arc therapy, since the photon contribution from
all beams is added at the isocentre and the isocentre may
be at a critical structure.
Comparison between two dose distributions
measured with film in a humanoid phantom:

(a) Small of 10o (small field width) exhibiting


a large photon contamination at the isocentre
(b) Large of 100o exhibiting a relatively small
photon contamination at the isocentre.

In electron arc therapy the bremsstrahlung dose


at the isocentre is inversely proportional to the
characteristic angle .

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.9 Slide 8

8.3 CLINICAL CONSIDERATIONS


8.3.9 Electron arc therapy

Shape of secondary collimator defining the field width w in


electron arc therapy is usually rectangular and the resulting
treatment volume geometry is cylindrical, such as foe
example in the treatment of the chest wall.

When sites that can only be approximated with spherical


geometry, such as lesions of the scalp, a custom built
secondary collimator defining a non-rectangular field of
appropriate shape must be used to provide a homogeneous
dose in the target volume.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.9 Slide 9

8.3 CLINICAL CONSIDERATIONS


8.3.10 Electron therapy treatment planning

Complexity of electron-tissue interactions makes treatment planning for electron beam therapy difficult and
look up table type algorithms do not predict well the
dose distribution for oblique incidence and tissue
inhomogeneities.

Early methods in electron beam treatment planning were


empirical and based on water phantom measurements
of PDDs and beam profiles for various field sizes,
similarly to the Milan-Bentley method developed for use
in photon beams.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.10 Slide 1

8.3 CLINICAL CONSIDERATIONS


8.3.10 Electron therapy treatment planning

Early methods in electron treatment planning accounted


for tissue inhomogeneities by scaling the percentage
depth doses using the CET approximation which provides
useful parameterization of the electron depth dose curve
but has nothing to do with the physics of electron
transport.

Fermi-Eyges multiple scattering theory considers a broad


electron beam as being made up of many individual pencil
beams that spread out laterally in tissue following a
Gaussian function.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.10 Slide 2

8.3 CLINICAL CONSIDERATIONS


8.3.10 Electron therapy treatment planning

Pencil beam algorithm can account for tissue inhomogeneity,


patient curvature and irregular field shape.

Rudimentary pencil beam algorithms deal with lateral


dispersion but ignore angular dispersion and backscattering
from tissue interfaces.

Despite applying both the stopping powers and scattering


powers, the modern refined pencil beam, multiple scattering
algorithms generally fail to provide accurate dose
distributions for most general clinical conditions.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.10 Slide 3

8.3 CLINICAL CONSIDERATIONS


8.3.10 Electron therapy treatment planning

The most accurate and reliable way to calculate electron


beam dose distributions is through Monte Carlo techniques.

The main drawback of the current Monte Carlo approach to


treatment planning is the relatively long computation time.

With increased computing speed and decreasing hardware


cost, it is expected that Monte Carlo based electron dose
calculation algorithms will soon become available for
routine electron beam treatment planning.

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Radiation Oncology Physics: A Handbook for Teachers and Students - 8.3.10 Slide 5

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