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    Subiecte Lucrare 1 2013-2014 English

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    Andrei Amza
    This document contains 10 sections with questions about virology and immunology concepts including: 1) Cytopathic effects of viruses and the clinical syndromes they cause 2) Isolating and identifying influenza viruses from samples 3) Advantages and disadvantages of live attenuated vaccines and cell cultures used to produce them

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    © All Rights Reserved
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    Subiecte Lucrare 1 2013-2014 English

    Uploaded by

    Andrei Amza
    31 views4 pages
    This document contains 10 sections with questions about virology and immunology concepts including: 1) Cytopathic effects of viruses and the clinical syndromes they cause 2) Isolating and identifying influenza viruses from samples 3) Advantages and disadvantages of live attenuated vaccines and cell cultures used to produce them

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    Subiecte Lucrare 1 2013-2014 English - Copy

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    This document contains 10 sections with questions about virology and immunology concepts including: 1) Cytopathic effects of viruses and the clinical syndromes they cause 2) Isolating and identifying influenza viruses from samples 3) Advantages and disadvantages of live attenuated vaccines and cell cultures used to produce them

    Copyright:

    © All Rights Reserved
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    31 views4 pages

    Subiecte Lucrare 1 2013-2014 English

    Uploaded by

    Andrei Amza
    This document contains 10 sections with questions about virology and immunology concepts including: 1) Cytopathic effects of viruses and the clinical syndromes they cause 2) Isolating and identifying influenza viruses from samples 3) Advantages and disadvantages of live attenuated vaccines and cell cultures used to produce them

    Copyright:

    © All Rights Reserved
    Download as DOC, PDF, TXT or read online from Scribd
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    You are on page 1of 4

    BILET 1

    1. What type of CPE is represented in this image? Which viruses can produce such changes? What are the
    clinical syndromes in which these viruses are frequently involved?

    2. How are influenza viruses isolated? What are the most appropriate samples to be collected and how can
    you identify influenza viruses presence in the sample? How can you identify the viral subtype?
    3. What are the advantages and disadvantages of live attenuated vaccines? On which type of cell cultures
    can these vaccines be produced? Why?

    BILET 2

    1. What reaction is represented in this image? When can you use it? What does A9 well represent?

    2. What is the mechanism of the antiviral activity of interferons?


    3. What is a diploid cell line? How is it obtained? Can you use a transformed cell line gor vaccine
    production? Why?

    BILET 3

    1. How do viruses enter in a cell? What is the mechanism of viral entry for enveloped and naked
    viruses?
    2. What type of reactions are represented in this image? During the diagnosis of which infection can
    you use this type of reactions? What does E8 well represent?

    3. How does a T-cell receptor recognize a viral antigen?


    BILET 4

    1. What type of CPE is represented in this image? Which viruses can produce such changes? What are the
    clinical syndromes in which these viruses are frequently involved?

    2. What type of viruses are characterised by antigenic variability? Why? What are the mechanisms behind
    this variability?.
    3. What is the role of dendritic cells in the antiviral immunity?

    BILET 5

    1. What type of CPE is represented in this image? Which viruses can produce such changes? In which
    phase of the viral replicative cycle do you see such changes?

    2. What is the role of T helper cells in antiviral immunity? How do these lymphocites recognize the
    antigen?
    3. How are influenza vaccines produced? Why do we have to reformulate the vaccine each year?

    BILET 6

    1. What type of CPE is represented in this image? Which viruses can produce such changes? In which
    phase of the viral replicative cycle do you see such changes?
    .

    2. Give an example of cellular cooperation in antiviral immunity .


    3. What type of reaction can you use for a rapid diagnosis in influenza?
    BILET 7

    1. How can you isolate influenza viruses? How can you identify the viral subtype ?
    2. How are interferons produced during a viral infection ? What are the roles of IFNs ?
    3. What type of CPE is represented in this image? Which viruses can produce such changes? In which
    phase of the viral replicative cycle do you see such changes?

    BILET 8
    1.What is the role of T cytotoxic cells in antiviral immunity? How do these lymphocites recognize the antigen?
    2.What type of reaction is represented in this image? During the diagnosis of which infection can you use this
    type of reactions?

    3. What is the difference between a negative single strandede RNA virus and a positive single strandede RNA
    one?

    BILET 9

    1. What type of CPE is represented in this image? Which viruses can produce such changes? In which
    phase of the viral replicative cycle do you see such changes?

    1. Influenza viruses infect many species. Why arent avian viruses easily transmitted to humans? How is
    the interspecies transfer made?
    2. Which types of cells participate in antiviral cytotoxicity?
    BILET 10
    What type of reaction is represented in this image? During the diagnosis of which infection can you
    use this type of reactions?

    1. What are initial phases in the viral lyfe cycle (eclipse) ?


    2. How can you obtain a live attenuated vaccine? Give an example of such a vaccine.

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