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    Stevia Has Anti-Diabetic Properties and Compares Favorably With The Drug Glibenclamide But Without The Adverse Effects

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    Ramona
    An animal study found that a medium-polar extract from Stevia rebaudiana leaves had antidiabetic properties in alloxan-induced diabetic rats, reducing blood glucose levels without causing hypoglycemia. The Stevia extract compared favorably to the drug glibenclamide in controlling blood sugar but without the adverse effects like hypoglycemia and weight loss seen with glibenclamide. The Stevia extract was found to protect pancreatic beta cells from alloxan necrosis.

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    Stevia Has Anti-Diabetic Properties and Compares Favorably With The Drug Glibenclamide But Without The Adverse Effects

    Uploaded by

    Ramona
    23 views2 pages
    An animal study found that a medium-polar extract from Stevia rebaudiana leaves had antidiabetic properties in alloxan-induced diabetic rats, reducing blood glucose levels without causing hypoglycemia. The Stevia extract compared favorably to the drug glibenclamide in controlling blood sugar but without the adverse effects like hypoglycemia and weight loss seen with glibenclamide. The Stevia extract was found to protect pancreatic beta cells from alloxan necrosis.

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    Stevia

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    Stevia Has Anti

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    An animal study found that a medium-polar extract from Stevia rebaudiana leaves had antidiabetic properties in alloxan-induced diabetic rats, reducing blood glucose levels without causing hypoglycemia. The Stevia extract compared favorably to the drug glibenclamide in controlling blood sugar but without the adverse effects like hypoglycemia and weight loss seen with glibenclamide. The Stevia extract was found to protect pancreatic beta cells from alloxan necrosis.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    23 views2 pages

    Stevia Has Anti-Diabetic Properties and Compares Favorably With The Drug Glibenclamide But Without The Adverse Effects

    Uploaded by

    Ramona
    An animal study found that a medium-polar extract from Stevia rebaudiana leaves had antidiabetic properties in alloxan-induced diabetic rats, reducing blood glucose levels without causing hypoglycemia. The Stevia extract compared favorably to the drug glibenclamide in controlling blood sugar but without the adverse effects like hypoglycemia and weight loss seen with glibenclamide. The Stevia extract was found to protect pancreatic beta cells from alloxan necrosis.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 2

    Stevia has anti-diabetic properties

    and compares favorably with the


    drug glibenclamide but without the
    adverse effects. - GreenMedInfo Summary
    Abstract Title:
    Antidiabetic activity of medium-polar extract from the leaves of Stevia rebaudiana Bert.
    (Bertoni) on alloxan-induced diabetic rats.

    Abstract Source:
    J Pharm Bioallied Sci. 2011 Apr ;3(2):242-8. PMID: 21687353

    Abstract Author(s):
    Himanshu Misra, Manish Soni, Narendra Silawat, Darshana Mehta, B K Mehta, D C Jain

    Article Affiliation:
    School of Studies in Chemistry and Biochemistry, Vikram University, Ujjain - 456 010,
    Madhya Pradesh, India.

    Abstract:
    OBJECTIVE: To investigate the medicative effects of medium-polar (benzene:acetone, 1:1,
    v/v) extract of leaves from Stevia rebaudiana (family Asteraceae) on alloxan-induced
    diabetic rats.

    MATERIALS AND METHODS: Diabetes was induced in adult albino Wistar rats by
    intraperitoneal (i.p.) injection of alloxan (180 mg/kg). Medium-polar extract was
    administered orally at daily dose of 200 and 400 mg/kg body wt. basis for 10 days. The
    control group received normal saline (0.9%) for the same duration. Glibenclamide was
    used as positive control reference drug against Stevia extract.

    RESULTS: Medium-polar leaf extract of S. rebaudiana (200 and 400 mg/kg) produced a
    delayed but significant (P<0.01) decrease in the blood glucose level, without producing
    condition of hypoglycemia after treatment, together with lesser loss in the body weight
    as compared with standard positive control drug glibenclamide.

    CONCLUSIONS: Treatment of diabetes with sulfonylurea drugs (glibenclamide) causes


    hypoglycemia followed by greater reduction in body weight, which are the most
    worrisome effects of these drugs. Stevia extract was found to antagonize the necrotic
    action of alloxan and thus had a re-vitalizing effect on-cells of pancreas.

    Article Published Date : Apr 01, 2011


    Study Type : Animal Study
    Additional Links
    Substances : Stevia : CK(64) : AC(25)
    Diseases : Diabetes Mellitus: Type 1 : CK(1130) : AC(301)
    Pharmacological Actions : Hypoglycemic Agents : CK(1446) : AC(342)
    Additional Keywords : Beta Cell Regeneration : CK(78) : AC(29), Superiority of Natural
    Substances versus Drugs : CK(1316) : AC(251)
    Problem Substances : Glibenclamide : CK(122) : AC(3)
    Adverse Pharmacological Actions : Hypoglycemic : CK(12) : AC(2)

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