DrinkMe

Start Time 17 24 h clock 3 v 3.21

2.8

Ethanol g/L
Body weight 85 kilograms 2.6
2.4
2.2
Clock Drinks Your Choice Time 2
g/L
1.8
17:00 1 Standard drink - 4% beer 12 Eat
0 TC###
0
###
### 1.6
Standard drink - 4% beer 1.4
17:30 1 12 Eat
0 TC###
0
###
### 1.2
18:00 1 Standard drink - 4% beer 12 0 0 1
Eat TC###
###
###
0.8
18:30 1 Standard drink - 4% beer 12 0
Eat 0
TC###
###
### 0.6
0.4
19:00 1 - 15 0
Eat TC 0
###
###
###
0.2
19:30 1 - 15 0
Eat TC 0
###
###
### 0

20:00 1 - 15 0
Eat 0
TC###
###
### 17 18 19 20 21 22 23 0 1 2 3 4 5 6 7
Time h
20:30 1 - 15 0 0
Eat TC###
###
###
21:00 1 - 15 0
Eat 0
TC###
###
### Type of drink mL v/v%
21:30 1 - 15 0
Eat 0
TC###
###
### Nick & Bill's Homebrew 500 6
22:00 1 - 15 0
Eat 0
TC ###
###
### Pint Steinlager 500 5
22:30 1 - 15 0
Eat 0
TC###
###
### Boilermaker (beer + whisky) 425 9.824
23:00 1 - 15 0
Eat 0
TC###
###
### Mac's Sassy Red - 5% beer 375 5
Eat=Food; TC=Tactical Chunder (vomit) ###
###
### Can - lite beer 375 2.7
###
###
### Glass of wine 100 12.5
Click checkboxes to remove ethanol from gut (TC) or slow
absorption (Eat) ###
###
### Korean 100 year old rice wine 100 13
###
###
### Talisker Malt Whisky 50 46
###
###
###
You have to click several Eat boxes to have any appreciable BaselBieter Kirsch 50 42
effect on concs. Each Eat checkbox slows absorption from###
###
### Glass of Port 50 15
the time of the checked box to the time of the next Eat
checkbox ###
###
### Tequila 50 37
###
###
### Standard drink - 4% beer 300 4
Show Science Sheet ###
###
### Cup of Green Goddess 150 9
###
###
### Double Vodka Red Bull 250 8
Show Data Sheet
###
###
### - 0 0
Show FA Model ###
###
###
###
### Tactical Chunder -1500 3.5
###
###
###
###
###
###

Excel macros must be enabled to run the clinical pharmacologist simulation model.

The idea for the Drink Me! worksheet came from an anonymous workbook developed by a financial
analyst. The financial analyst model assumes the dose is instantaneously and completely absorbed
one hour after the nominal time of the drink. It is then eliminated by an approximate first-order process.
The Excel workbook (drink plan.xls) on which this worksheet is based has been found at:
http://www.geocities.com/beerbeerbeerandbrisbane/
The clinical pharmacologist model is described in more detail on the Science worksheet. The graph on
the Drink Me! worksheet compares the financial analyst model with the well stirred mixed-order
elimination model.
The tactical chunder is implemented as an immediate loss from the gut. The ethanol amount lost is
constrained not to be more than the amount remaining to be absorbed.

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The effect of food (Eat) is to slow the rate of absorption of ethanol from the gut.

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Effects of Ethanol
Ethanol PKPD Web Page
Possible death Death from respiratory paralysis

Coma Coma and anaesthesia. Depressed or abolished reflexes. Hypothermia, impaired circulation and
respiration. Possible death.
Stupor Apathy, general inertia, approaching paralysis. Marked lack of ability to stand or walk.Vomiting,
incontinence, stupor, sleep, coma

Confusion Disorientation, mental confusion and dizziness, Exaggerated emotions - fear, anger and
grief. Some loss of perception. Decreased pain sense, impaired balance and slurred speech. Sleep in the
absence of stimulating input.
Excitement Emotional instability, and loss of initial judgement. Decreased perception and co-ordination,
staggering gait. Increased reaction time, possible nausea, desire to lie down.

LEGAL DRIVING LIMIT IN MANY COUNTRIES

Blood ethanol concentration 0.5 g/L
Euphoria Increased self confidence, and decreased inhibitions. Loss of attention, judgement
and control, by decrease in co-ordination and sensory perception
2 3 4 5 6 7 Animation Subject may be more talkative and have a feeling of well-being. Slightly slower
reactions.

g Clinical Pharmacologist Model

24 Volume of distribution (L/70kg) ###
20 Maximum Elimination Rate (g/h/70 kg) ###
33 Ethanol concentration at 50% of Max Elim Rate (g/L) ###
15 Absorption Half-Life (h) ###
8
Holford NHG. Clinical pharmacokinetics of ethanol. Clinical Pharmacokinetics
10 1987;13:273-292
10
18
Holford NHG. Complex PK/PD models - an alcoholic experience. International
17 Journal of Clinical Pharmacology and Therapeutics 1997;35(10):465-468
6 Caution: These simulations are based on models.
15 "All models are wrong but some are useful" George Box
10 The predictions are based on average population parameters
11 and do not reflect person to person variation except to the
16 extent that differences may be predicted from body weight.
0 Box GE. The Collected Works of GEP Box. Belmont, CA: Wadsworth Advanced
Books and Software; 1985
-42

ation model.

a financial
ly absorbed
-order process.
t:

. The graph on
d-order

ount lost is

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