Sinarest Tab
Sinarest Tab
Sinarest Tab
COMPOSITION
Paracetamol IP 500 mg
Phenylephrine hydrochloride IP 10 mg
Chlorpheniramine maleate IP 2 mg
Caffeine (anhydrous) IP 30 mg
DESCRIPTION
Sympathomimetic decongestants reduce the nasal congestion due to increased nasal blood
flow associated with colds and influenza. Phenylephrine is sympathomimetic vasoconstrictor
that has been used as a decongestant. It is a relatively selective alpha-adrenoceptor agonist.
The majority of the sympathomimetic action is due to direct stimulation of the adrenoceptors
and relatively little is due to an indirect effect via release of noradrenaline. Its pressor action is
weaker than that of noradrenaline but of longer duration. At therapeutic doses, it does not
cause significant stimulation of the central nervous system.
Chlorpheniramine in SINAREST Tablet provides prompt relief of itchy- watery eyes, runny nose,
sneezing, itching of the nose or throat due to respiratory allergies.
Caffeine in SINAREST Tablets enhances the analgesic activity of Paracetamol and serves to
reduce incidence of sedation due to Chlorpheniramine maleate.
The pharmacokinetics of this combination of SINAREST Tablet is well matched and synergistic.
All the drugs are well absorbed orally.
INDICATIONS
•Relief of allergic symptoms of the nose or throat due to upper respiratory tract allergies.
CONTRAINDICATIONS
•Severe hypertension.
PRECAUTIONS
SINAREST Tablet contains Paracetamol and therefore should not be used in conjunction with
other Paracetamol containing products.
SINAREST Tablet should be used with caution in patients with renal or hepatic dysfunction,
diabetes mellitus, hyperthyroidism, cardiovascular problems, epilepsy and closed angle
glaucoma.
It is advisable not to drive or operate machinery when on treatment with SINAREST Tablet.
DRUG INTERACTIONS
SINAREST Tablet is generally well tolerated and adverse events are rare. Hypersensitive
individuals may display ephedrine-like reactions such as tachycardia, palpitations, headache,
dizziness and nausea. Use of sympathomimetics has been associated with fear, anxiety,
restlessness, tremor, weakness, dysuria, insomnia, hallucinations and convulsions.
Chlorpheniramine in SINAREST Tablet may cause sedation.
PRESENTATION