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Losartan Potassium Drug Study

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DRUG NAME CLASSIFICATION INDICATIONS CONTRAINDICATIO ROUTE & DOSAGE DRUG ACTION ADVERSE EFFECTS

NS
Generic name: Cardiovascular Losartan is used for Hypersensitivity to PO: The usual Angiotensin, Side effects
Losartan agent treating losartan starting dose of formed in the blood reported included
Potassium hypertension, left losartan for adults by the action of diarrhea, muscle
Angiotensin II ventricular Pregnancy is 50 mg daily. The angiotensin cramps, dizziness,
Brand name: receptor antagonist hypertrophy [category C (first maximum dose is converting enzyme insomnia, and nasal
(increase in trimester), category 100 mg daily. The (ACE), is a powerful congestion.
Cozaar Antihypertensive muscle) and D (second and third total daily dose chemical that Losartan also may
diabetic trimesters)] may be divided and attaches to cause a persistent
nephropathy administered twice angiotensin cough, increase
(kidney disease). Lactation daily. Losartan may receptors found in serum potassium,
be given with or many tissues but and angioedema.
without food. primarily on smooth Losartan may
The starting dose of muscle cells of reduce kidney
losartan for blood vessels. function in some
pediatric patients 6 Angiotensin's patients and should
years of age or attachment to the not be used by
older is 0.7 mg/kg receptors causes patients who have
up to 50 mg once the blood vessels to bilateral renal
daily. Doses more narrow artery stenosis
than 1.4 mg/kg or (vasoconstrict) (narrowing of both
100 mg daily have which leads to an arteries going to
not been evaluated increase in blood the kidneys). Rare
in pediatric pressure cases of
patients. (hypertension). rhabdomyolysis
Losartan (more (muscle
specifically, the breakdown) have
chemical formed been reported.
when the liver
converts the
inactive losartan
into an active
chemical) blocks
the angiotensin
receptor. By
blocking the action
of angiotensin,
losartan dilates
blood vessels and
thereby reduces
blood pressure.
NURSING Assessment
CONSIDERATIONS Monitor BP at drug trough (prior to a scheduled dose).
Monitor drug effectiveness when losartan is used as monotherapy.
Inadequate response may be improved by splitting the daily dose into twice-daily dose.
Lab tests: Monitor CBC, electrolytes, liver & kidney function with long-term therapy.

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