The Secret of Natural Remedies

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THE SECRETS OF
NATURAL REMEDIES
THE ULTIMATE GUIDE TO STAYING HEALTHY AND HAPPY
FROM SUPERFOODS TO ALTERNATIVE THERAPIES
FROM TH E M AKERS O F
FOCUS M AG A ZI N E
AL
I
EC ER
SPOFF
FOCUS
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TH E U LTI M ATE M AGA ZI N E FO R CU RI O US MI N DS
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THE FOCUS COLLECTION
THE SECRETS OF
NATURAL REMEDIES
THE ULTIMATE GUIDE TO STAYING HEALTHY AND HAPPY
FROM SUPERFOODS TO ALTERNATIVE THERAPIES
FROM TH E M AKERS O F FOCUS M AGA ZI N E

INTRODUCTION
WELCOME
Superfoods, stress doesn’t cut it – remember how blood-letting was a
busting techniques, popular therapy for centuries?
herbal remedies, health So, what about staying fit and the food on our
hacks, meditation, plates? Which fads are worth the hours in the gym
mystic Eastern practices. or indulging yourself in?
Our lives are forever On page 10, discover the Science of Superfoods.
bombarded by brands From kale to quinoa, salmon to spinach, find out
and social media trying to sell us tips and tricks for which foods deserve the ‘super’ prefix. In Health
leading a healthier, happier life – the natural way. Hack or Quack, on page 18, find out which
Wading through this information overload can be renowned (and lesser known) herbal remedies
exhausting. In this special issue, we’ve extracted really work. Sneak preview: high five to the new
the science and interviewed the experts to give you beauty fad – anti-ageing argan oil – and thumbs
the low down on which natural remedies are down to evening primrose oil.
worth spending your hard-earned cash on – and On page 26, discover why bacterial bugs are
which to avoid. actually good for you and, on page 62, dive into
Some natural remedies have been popular in shallow seas and explore the depths of the jungle
some cultures for centuries – like acupuncture as you go bio-prospecting for new natural
or yoga – while others have only recently grown remedies from the wild.
in popularity, such as the rise of superhero Plus, answers to key health questions (page 70),
superfoods. But the big question is which ones exercise secrets to boost the body and bust the
work – and which don’t. Well, it depends on who belly (page 40), and natural remedies that help
you talk to. Science backs up a number of natural through pregnancy and birth (page 48). Chill out
remedies, while for other lotions, potions, or with stress-busting tips (page 54), find out about
practices, scientists can’t find any rhyme or reason the history and science behind mystic Eastern
why they make us feel so good – it may simply be practices (page 80). And, discover the truth about
the placebo effect (see page 89) at work. acupuncture (page 86), chiropractic therapy (page
You might think that a remedy, which isn’t 94) and other alternative medicines (page 100).
supported by science but has been recommended Finally, on page 106, explore the inner workings of
by a friend (or tenacious marketer), is perfectly your mind as you discover the science behind how
harmless – and, if the placebo effect works for you, mindfulness meditation works.
why not go for it? But the bad news is that some of And breathe...ommm.
these natural remedies or alternative therapies are
actually detrimental to your health – and, in
certain cases, can cause serious harm. The fact
that they’ve been practised throughout history Daniel Bennett, Editor
4 The Secrets of Natural Remedies

MIRACLE NUT
Oil from the nuts of
the argan tree has
anti-ageing properties
ALAMY
The Secrets of Natural Remedies 5

CONTENTS
HEALTH & FITNESS ALTERNATIVE THERAPIES
10 The Science of Superfoods 80 Eastern Influence
Discover which nutrionally dense foods The health benefits of yoga and tai chi
deserve the ‘super’ prefix
86 Acupuncture Unravelled
18 Health Hack or Quack The truth behind this ancient practice
Find out which herbal remedies really
GETTY IMAGES / ILLUSTRATION: ROBIN BOYDEN

work – and which ones are pure hype 94 To Crack or Not to Crack
Sorting fact from fiction in chiropractic therapy
26 The Power of Bacteria
Discover why microbes are good for us, and 100 The Good, the Bad and the Ugly
how they affect our mood
Revealing the alternative therapies that
work – and the ones that don’t
40 Exercise: a Cure for all Ills
Learn about the health benefits that exercise 106 All in the Mind
offers, helping to combat all sorts of ailments
Discover the impressive benefits of mindfulness
meditation – and how it can change your brain
48 A Helping Hand
From folic acid to hypnotherapy, discover
natural remedies for pregnancy and birth
54 Stress Busters
Top 20 ways to stay calm, healthy
and happy when life gets busy
62 Nature’s Pharmacy
Discover the natural remedies
lurking in the depths of our
oceans and jungles
Q&A
SPECIAL
70
34
10
48 40
100
106
HEALTH
& FITNESS
NATURAL WAYS TO ENJOY LIFE TO THE FULLEST
+ The science of SUPERFOODS

+ HEALTH HACKS Herbal remedies
which work (and the ones that don’t)
+ The power of BACTERIA
Why bugs are suprisingly good for us
+ The real benefits of EXERCISE
+ Natural remedies to help through
PREGNANCY AND BIRTH
+ Top 20 STRESS BUSTERS
+ NATURE’S PHARMACY
Natural remedies from the wild
GETTY IMAGES

HEALTH & FITNESS Superfoods
The Science of
Superfoods
Kale and chia, goji berries and blueberries, salmon and
spinach. JAMIE MILLAR investigates the science behind
ISTOCKPHOTO
whether superfoods are the magic bullet that can cure all
our ills, and which ones deserve their ‘super’ prefix

GETTY IMAGES

illed as the superheroes carotene than carrots and more iron The appetite for superfoods is
B
of the culinary world, than spinach. They are often exotic in growing – according to the
today, superfoods are origin – the goji berry hails from the International Food Information
as widespread as Himalayas. “This seems to suggest Council, nearly nine in 10 Americans
comic-book films that they have some special health- are interested in foods that have
– every day a new promoting properties,” says Dr. health benefits beyond basic nutrition
one hits our plates. Blumberg. “Although the countries (what the IFIC calls ‘functional
“There is neither a regulatory nor from which they come are not foods’). But they’re also swallowing
scientific definition of a ‘superfood’,” characterised by especially healthful some unsubstantiated claims.
says Dr. Jeffrey Blumberg, from the or long-lived people.” Legends of doctors discovering
Friedman School of Nutrition remote mountain tribes of age-
Science and Policy at Tufts Be ready to fork out defying, goji-munching centenarians
University, Boston. “It is a marketing Indeed, superfoods are often should self-evidently be taken with a
term which marketers apparently do rediscovered and repackaged staples large pinch of pink Himalayan sea
not wish to define either.” However, of ancient civilisations, which also salt – another superfood with little
through an equally unscientific lends them credibility and a quasi- scientific backing to elevate it above
survey of the books and blogs that mythical air, even though those the table variety. But there’s scarcely a
liberally sprinkle the term – more ancient civilisations are long-dead. grain of proof for the efficacy of the
on those later – some common Like the goji berry, which allegedly goji berry or any other superfruit.
characteristics of these so-called helped Chinese herbalist Li Ching A 1994 Chinese study of 79
superfoods can be discerned. Yuen live to the ripe old (unverified) patients with advanced cancers found
Superfoods typically have high age of 256. Coincidentally, he also that their conditions regressed when
levels of certain nutrients – such as sold goji berries. Which leads us to treated with goji polysaccharides – in
the goji berry, which boasts more perhaps the defining characteristic of conjunction with immunotherapy.
vitamin C than oranges, more beta most superfoods – they’re expensive. But information about the design of
GETTY IMAGES
GOJI BERRIES
Popular among celebrities
from Madonna to Miranda
Kerr, goji berries have high
levels of certain nutrients

the study and the compounds used is,
like evidence for the majority of goji’s
Everest-sized claims, lacking. Another
study, on goji juice’s effects on brain
activity, was only performed on 34
people, and inconclusive at that.
Most of the various studies related
to goji and immunity, heart disease,
and life expectancy have been either
small, or used concentrated extracts
which would be unrealistic – not
to mention costly – to eat the
equivalent of in real life.
Free radicals
Like many superfoods, such as açaí
and blueberries, goji berries are touted
as being high in dietary antioxidants.
“They act to quench reactive oxygen,
nitrogen and halide species – often
called ‘free radicals’,” explains Dr.
Blumberg, who is also the senior
scientist at Tufts’ Antioxidant
Research Lab in the US. Free radicals GREEN GIANTS Vegetables are known to contain all sorts of beneficial vitamins and
minerals. For example, kale has been found to lower the risk of cancer and heart disease
are commonly cited as causing cancer
– the marketing goes then that more
antioxidants means less cancer. The For one thing, more is not always that much good either. “While
science is not so straightforward. better. “While consuming more antioxidants are what marketers focus
“Many free radicals play important, antioxidant-rich fruits, vegetables, on, the science does not indicate that
positive roles in cell biology and whole grains, nuts and seeds can they’re the most important part of a
human physiology,” says Dr. certainly be good, everything can be food’s nutritional repertoire,” says
Blumberg. “In excessive amounts, harmful at a high enough intake,” Kamal Patel, a nutrition researcher
though – generally referred to as says Dr. Blumberg. One study on and director of examine.com, an
‘oxidative stress’ – they can damage people at risk of developing lung independent study analysis website.
cell constituents like lipids, proteins, cancer had to be stopped because “The federal government used to use
and DNA, and contribute both to the those given antioxidants were dying the ORAC antioxidant scale, but no
aging process and the development of more quickly. But while a diet that’s longer does due to lack of support for
many chronic diseases, including high in antioxidant-rich produce its impact on health.”
cancer. However, this simple concept probably won’t do you much harm – Nor will the presence of high levels
is actually extraordinarily complex, unless you consume them in wine of antioxidants in a food, super or
and incompletely understood.” form – they won’t necessarily do you otherwise, necessarily result in a
proportional antioxidant effect. For
example, anthocyanins, found in the
The goji berry boasts more vitamin C than blueberry – often referred to as
the grandaddy of the superfood
oranges, more beta carotene than carrots movement – have been shown to
GETTY IMAGES
inhibit growth of cancerous human

and more iron than spinach colon cells in vitro. But there’s no
evidence that the flavonoids, the class ´

The problem is not that superfoods are a con

– many are highly nutritious – but calling
of antioxidants that anthocyanins
belong to, are even absorbed in the them ‘super’ gives unrealistic expectations
human body – indeed, studies show
that less than five per cent survives
consumption and is promptly
excreted. “When you consume an in North Carolina. “But the North theme in the new 2015-2020 dietary
antioxidant, the main antioxidant Carolina university system demands guidelines for Americans,” says Prof.
effect often comes from your body’s contractual agreement that gives the Nieman. “The term ‘superfood’ is not
reaction to consuming a foreign primary investigator ‘academic used by most scientists in the field,
substance, rather than from the freedom’, or the right to publish the because the implication is that one
substance itself,” says Patel. “Plus, data, positive or negative. Many of can expect quick and high-end health
our body’s own antioxidant the companies I work with are so benefits.” By all means, sprinkle some
systems – involving compounds like convinced that their product has chia seeds on your oatmeal, and even
glutathione – are more powerful special effects that they sign these stir in some blueberries. You’ll get a
than what we can get from food.” agreements.” What buyers should nutritional boost, you just won’t
beware of are studies conducted instantly become immortal: “What
Tricky to study in-house by companies, which are matters is the habitual eating pattern
The proof of the superfood pudding “close to worthless”, says Prof. over months and years.”
is in the eating – by humans, not Nieman. But while industry-funded
mice or rats. But unfortunately, most doesn’t mean false, the anointed A balanced diet
scientific research is not conducted superfood might not be much By seeing superfoods as a magic
this way. “Nutrition studies often better than a cheaper, less exotic bullet, we risk shooting ourselves in
don’t apply to real life on a 1:1 basis,” equivalent that doesn’t have the same the foot. “Some people think if they
says Patel. “If you want to test, say, commercial imperative (see page 17). eat one ‘superfruit’, they don’t need to
the effect of grape juice on cognition, The problem is not so much that eat the recommended 2-4 servings of
you’d give it enough time, plus you’d superfoods are a con – many of fruit a day,” says Dr. Blumberg. But
check to make sure they actually them, like chia seeds (right) or kale, no one superfood is a panacea; nor
drink it. In real life, that almost never are highly nutritious – more that will it make up for other deficiencies.
happens.” Lifestyle factors are calling them ‘super’ gives unrealistic “Adding superfoods to a good diet is
difficult if not impossible to separate. expectations of what they will do. fine,” says Dr. David Katz, Director
And there are other problems, says “I prefer the concept of ‘high nutrient of Yale University’s Prevention
Patel: pilot studies and animal trials density’ foods, which is a central Research Center in the US.
will often use larger dosages, while “Counting on them to compensate
‘acute’ studies will look at just the for a bad diet is not.” And undue
food without any other things emphasis on superfoods can be
consumed. Meanwhile, eating unhealthy. “The term helps
different foods together, which is companies sell product,
what most of us do, can dramatically and it ‘helps’ consumers
alter their effects for better or worse: oversimplify their diets,”
“Co-consumption makes things says Patel. All the experts
more complicated.” cited here stressed the
Another issue affecting superfood importance of consuming
research is that it is often paid for by a wide variety of natural,
interested parties. “We’re funded by ‘whole’ foods, which in
food and supplement companies in turn reduces their individual
many of the studies we conduct,” The blueberry is significance. “No single food or
GETTY IMAGES
admits Professor David Nieman, often referred to beverage is important enough to

as the grandaddy
Director of the Human Performance of the superfood stand out from the overall
Labs at Appalachian State University movement lifestyle,” says Prof. Nieman. ´

Inflated health benefits
The chia seed is a good example of how claims about superfoods can grow out of all proportion
A variety of mint, over recent years minerals. Indeed, cheerleaders of State University in North Carolina.
chia has broken out of those chia allege you could eat it and “We conducted several randomised
novelty pet-shaped pot plants to nothing else. human trials showing that chia
become an Aztec warrior miracle “It’s a good example of how seeds provide good nutrition and
food. It’s a complete protein with all companies and distributors can be included in a healthy eating
the amino acids required to build promote the mystique and magical pattern that over time – along
muscle, plus more omega-3 than health benefits that go way beyond with physical activity and weight
GETTY IMAGES
salmon, more fibre than flaxseed, the science,” says Professor David management – is consistent with
and wealthier than Montezuma Nieman, Director of the Human good health. But there’s nothing
himself in antioxidants and Performance Labs at Appalachian quick or miraculous about them.”

SOUTHERN CLIMES
Fields of the crop quinoa
lie in front of a majestic
mountain range in Chile
Another unintended consequence overlook other beneficial foods. Ultimately, while superfoods may
of the fashionable superfood label can “Açaí and other exotic-sounding be a misnomer, we shouldn’t throw
be felt in their countries of origin as foods haven’t been shown to be the broccoli out with the coconut
they attain trendy status in the healthier than other foods, and there water (a sugary waste product of
developed world. Quinoa, aka ‘the are few if any long-term studies on farming that is no better for
miracle grain of the Andes’, tripled in their effects on disease,” says Patel. rehydration than plain old H2O).
price between 2006 and 2011, If such things as superfoods exist, “The term is more about
becoming too expensive for many in then they’re hiding behind their marketing than meaning,” says
its native Peru and Bolivia. Diversity secret identities as the mild-mannered Dr. Katz. “But, of course, there is no
of crops also takes a hit as farmers Clark Kents of the supermarket clear definition of ‘junk food’ either.
jump on the lucrative bandwagon. produce section. “Garlic has a tonne Sometimes we understand terms
And, ironically, people in those of evidence,” says Patel. “Potatoes are without precise definitions. And
countries wind up eating more cheap, nutritious and filling, yet they being nutrient-dense does, in general,
imported junk food, because it’s don’t get much attention – or they make a food better. There are
cheaper. (However, quinoa is now get negative attention, because they complications in how nutrients are
being grown in the UK.) Meanwhile, have white flesh.” metabolised, of course. But that
the Ethiopian government recently doesn’t undermine the value of
lifted a ban on the export of teff (a naturally nutrient-rich foods.”
gluten-free super-grain), which was Potatoes are cheap, They just aren’t necessarily the
imposed in 2006 amid fears of a grain most heavily marketed ones. Or the
shortage. They’re increasing yield by and nutritious, yet most expensive. Rather than hero-
40 per cent first to ensure adequate
supply, but there are still concerns.
they don’t get much worship particular superfoods, think
of your diet as like The Avengers: a
Superfoods can be costly for us too attention – or they diverse assortment of colourful
GETTY IMAGES
– they drive us to spend more, feed characters with different powers that
the untrue notion that healthy eating get negative attention work well together. And the largest
has to be expensive, and lead us to part of it should be green. ■

Everyday heroes
They’re not new or exotic, and they don’t always grab the headlines. But if these widely
available ‘superfoods’ aren’t already in your kitchen, they should be
GARLIC EXTRA-VIRGIN
Better known for warding OLIVE OIL
off vampires and first A Mediterranean mainstay,
dates, there is evidence the the healthy fats in this
bulb can lower blood cure-oil cut cardiovascular
pressure and cholesterol, disease and inflammation.
plus even prevent colds But don’t fry with it – high
and certain cancers. heat damages its nutrients.
BROCCOLI APPLE
Containing high levels of Crunching this doctor-
vitamin C and folate deterring fruit, which is
(natural folic acid), this high in antioxidants and
fibrous cruciferous fibre, has been associated
vegetable can stem with reduced risk of
cholesterol and cardiovascular disease,
triglycerides, which cause diabetes, asthma and
cardiovascular disease. some cancers.
ONION WALNUT
A member of the alium This has the highest
family, it contains a antioxidant activity of any
potent anti-inflammatory nut and is the only one with
antioxidant called a significant amount of
quercetin, which reduces omega-3. A review
blood pressure and suggests they could stave
cancer risk. off cardiovascular disease.
TOMATO BEET
Technically a fruit, it is low Rich in iron and folate, beets
in starch and sugar, but can make you hard to beat
high in fibre, vitamin C, – their nitrates lower blood
beta-carotene and a pressure and your personal
potent antioxidant called best time, while some
lycopene. Cooking in olive studies show improved
oil increases its absorption. exercise performance.
SPINACH SALMON
Popeye’s preferred Think pink. Oily fish reduces
GETTY IMAGES / ISTOCKPHOTO
superfood packs high levels cardiovascular disease risk,

of bone-strengthening lowering blood pressure,
calcium and vitamin K, and lubricating arterial fat
as well as vitamin A, build-up. Salmon is high in
and almost as much iron omega-3, vitamin D, some
as beef. B vitamins and selenium.

HEALTH & FITNESS Health Hack or Quack
Health Hack
or Quack
In this A-Z of popular herbal remedies,
LUIS VILLAZON sorts fact from
fiction, revealing which work and
which are pure hype
What the scores mean

We looked at the available scientific
research to determine how much
evidence there is for any claimed
health benefits of each herbal remedy.
왎 첸 첸 첸 첸 Placebo (see page 89)

왎 왎 첸 첸 첸 Mostly hype
왎 왎 왎 첸 첸 Conflicting evidence
왎 왎 왎 왎 첸 Seems promising
왎 왎 왎 왎 왎 Cure
GETTY IMAGES
Echinacea purpurea,
commonly known as
the purple coneflower

´

The yellow fruit

of the argan tree,
Argania spinosa,
which contains
the argan nut
C IS FOR
CHLORELLA
Chlorella pyrenoidosa is a single-
celled freshwater alga that has been
explored as a potential food source,
because it is high in protein and
calories. As a medical supplement
though, the benefits are much less
convincing. Several studies have
looked in vain for antioxidant, blood
pressure lowering or weight loss
effects. There is some very limited
evidence that it might boost the
immune system, and reduce the
symptoms of fibromyalgia, but a lot
more research would be needed to
confirm these effects.
RATING 왎 왎 첸 첸 첸
D IS FOR
DONG QUAI
Also known as ‘female ginseng’,
dong quai is a relative of the angelica
plant. It is sometimes prescribed by
practitioners of Traditional Chinese
Medicine for symptoms of
menopause or painful menstruation.
Some laboratory research has shown
that it relaxes the muscles of the
A IS FOR
ARGAN OIL
The argan nut grows in Morocco on
B IS FOR
BEE POLLEN
Bee pollen is just ordinary flower
uterus and opens blood capillaries,
but studies that looked for actual
therapeutic benefits in human
those thorny trees that goats climb. pollen that happens to have been patients have generally found it is no
It’s added to many cosmetics and collected by bees. It’s a mixture of better than a placebo. And it may
toasted argan oil is also used in sugar, protein and fat, which makes even be dangerous in some
cooking. The oil contains it a fairly high-energy food source, circumstances, since it’s been shown
antioxidant vitamin E, and linoleic but that’s about it. The claims that it to interfere with blood clotting.
acid, which has anti-inflammatory is an effective treatment for cancer, RATING 왎 첸 첸 첸 첸
properties. A recent study found or that it can boost athletic or sexual
that it improves the elasticity of the performance, is not backed up by
skin of postmenopausal women – any hard scientific data.
making it look younger and wrinkle- RATING 왎 첸 첸 첸 첸
free. This seems to work whether
it’s applied as a cream or taken
internally, so you might as well eat
GETTY IMAGES
it because it can also lower your It’s a myth that

pollen collected
blood cholesterol. by bees can
RATING 왎 왎 왎 왎 첸 treat cancer

The herb Echinacea is
E IS FOR
ECHINACEA
Also known as purple coneflower,
extracted from the
purple cone flower,
Echinacea purpurea
Echinacea purpurea contains

polysaccharide compounds that
are thought to increase the activity
of the immune system. Several
studies have attempted to test
the herb as a treatment for the
common cold, and the results are
decidedly mixed. A large study in
2007, for example, found that it
reduced both the duration of
cold infections, and your chances
of catching a cold. Meanwhile,
two other studies funded by
the National Center for
Complementary and Integrative
G IS FOR GREEN-LIPPED
MUSSEL EXTRACT
New Zealand green-lipped mussels
H IS FOR
HYALURONIC ACID
You have around 15g of hyaluronic
Health (part of the National contain certain fats that are known acid in your body right now. It’s a
Institutes of Health in the US) to have an anti-inflammatory effect. large molecule that acts as a
found no benefit. Because of this, green-lipped mussel lubricant and a filler in the skin, eyes
RATING 왎 왎 왎 첸 첸 extract has been studied as a possible and joints. Hyaluronic acid is used
treatment for arthritis. The evidence by plastic surgeons to plump out lips
isn’t very strong, however. Several and it’s a common ingredient in skin
F IS FOR
FOLIC ACID
Folate or vitamin B9 can’t be
comprehensive reviews of multiple
studies have concluded that it is no
better than a placebo. This might
moisturising creams. There’s no
evidence that taking hyaluronic acid
orally has any anti-aging effect on
synthesised within the body so be because the active ingredient the skin, but some studies have
we have to obtain it from our diet. degrades once it is extracted into shown that it reduces the symptoms
Since 1998, the FDA in the US has pill form. of arthritis in the knee.
required that folic acid is added to RATING 왎 왎 첸 첸 첸 RATING 왎 왎 왎 첸 첸
bread, cereal, rice, pasta and flour.
Folate is particularly important Folic acid is important
for the development
during the early development of a healthy foetus
of the foetus, so woman of
childbearing age are recommended
to take an extra 0.4 mg/day to
reduce the risk of neural tube
defects and premature birth.
Surprisingly, a 2013 study in mice
found that the foetus can also be
affected by the low folate levels in
the father’s diet. Folic acid can
affect which genes in the sperm are
activated, so a B9 supplement or a
healthy diet rich in dark leafy
GETTY IMAGES
vegetables is important for

prospective fathers too.
RATING 왎 왎 왎 왎 왎 ´

The nectar from
I IS FOR
IRON
Iron deficiency is the most common
the Manuka tree
in New Zealand
can be made
into honey
nutritional deficiency in the world,

but in the UK it is rare because
foods, such as bread, are often
fortified with iron. A 2012 study
found that adult women may be
mildly iron deficient even if they are
not medically anaemic, and taking
iron supplements reduced how tired
they felt. However, the effect was
very small, and too much iron is
certainly harmful. Accidental
overdoses of iron supplements are a
leading cause of child poisoning
K IS FOR
KRILL OIL
Red krill oil comes from the shrimp-
M IS FOR
MANUKA HONEY
Honey is a broad spectrum
deaths in the US, so keep your like crustaceans that whales eat. It antibiotic, but we still don’t fully
tablets locked safely away. contains eicosapentaenoic acid and understand how it kills bacteria.
RATING 왎 왎 왎 왎 첸 docosahexaenoic acid, commonly Manuka honey is made from the
known as omega-3 fatty acids – nectar of the New Zealand Manuka
well known for reducing the risk of tree and has the strongest
heart disease. It’s claimed that krill antibacterial effect. But lab studies
St. John’s Wort oil is more effective than fish oil, but have so far failed to translate this
is a good natural
anti-depressant the evidence is much less conclusive. into significant benefits in human
It may be that the slightly different patients. Manuka honey dressings
chemical composition of the might shorten healing times slightly
omega-3 in krill oil makes it more for moderate burns, but the evidence
easily absorbed, but even if true, it for other wounds is quite weak.
would only mean you need a smaller RATING 왎 왎 왎 첸 첸
dose to achieve the same effect.
RATING 왎 왎 왎 첸 첸
J IS FOR
ST. JOHN’S WORT
L IS FOR
L-CARNITINE
Carnitine is an amino acid used by
Several large-scale reviews of studies virtually all your cells in the release of
involving St. John’s Wort have energy. It’s produced in the body, so
concluded that it is more effective at normally there’s no need to take it as
treating depression than standard a supplement. There is some evidence
anti-depressants. The results of that taking L-carnitine (which is the
individual trials vary wildly, though, biologically active form) can improve
in part because the amount of the sperm function, and it may also help
GETTY IMAGES / ALAMY
active ingredient in St. John’s Wort repair muscle damage following

tablets can differ from the amount exercise. Research doesn’t support
claimed on the bottle by a factor of other claims that it boosts athletic
L-carnitine is thought
two or more. performance or increases muscle mass. to help repair muscle
RATING 왎 왎 왎 왎 첸 RATING 왎 왎 왎 왎 첸 damage post exercise

N IS FOR
NETTLE
There is some evidence that stinging
Nettle root has
been found to help
combat hay fever
and osteoarthritis
nettle root is effective against male

urination problems caused by an
enlarged prostate, such as difficulty
urinating or incontinence. We don’t
know how this works yet, because
other studies have shown that nettle
definitely doesn’t actually reduce the
size of the prostate. Nettle also has
an antihistamine effect, and some
studies have found that it helps
against osteoarthritis and hay fever.
RATING 왎 왎 왎 왎 첸
P IS FOR
PRIMROSE OIL
Extracted from the seeds of the
evening primrose plant, it contains
gamma-linolenic acid (GLA), which CoEnzyme Q-10
is also found in borage oil and can help treat
high blood
blackcurrant oil. Evening primrose pressure
has been heavily promoted in the
O
past as a treatment for pre-menstrual
IS FOR syndrome (PMS) and eczema. The
ODOURLESS GARLIC
Diets naturally high in garlic are
known to be associated with low
incidence of colon cancer, and there
US National Institute of Health and
the FDA both agree, however, that
there isn’t enough evidence to
support either claim. There are some
Q IS FOR
Q-10
Coenzyme Q-10 is produced
is some evidence that taking garlic in studies that did find a benefit, but naturally in the body and is used
an odourless capsule form provides these have subsequently been by the mitochondria in your cells
the same protection. Garlic capsules criticised as poorly designed. Most of to produce energy. Studies show
also seem to lower blood pressure the research in support of evening that it can be an effective treatment
slightly, but we still don’t know if primrose was sponsored by Efamol for chronic heart failure or high
this results in fewer deaths from Ltd – a company that marketed the blood pressure. But the evidence
heart disease. And an extensive study supplement – and the British for its usefulness against a wide
at Stanford in the US, published in Medical Journal has since called range of other diseases including
2007, found that garlic, in any form, evening primrose oil “the remedy for cancer and fibromyalgia is
does not reduce blood cholesterol. which there is no disease”. currently inconclusive.
RATING 왎 왎 왎 왎 첸 RATING 왎 왎 첸 첸 첸 RATING 왎 왎 왎 첸 첸 ´

R IS FOR
RASPBERRY KETONE
This chemical is used as a flavouring
in the food industry, but it is also
sold online as a weight-loss medicine.
Studies in rodents have shown that
at very high doses, raspberry ketone
alters the metabolism to increase
the rate at which fat is burned.
But there is no evidence that this
works in humans.
RATING 왎 왎 첸 첸 첸 The spiky fruit
of the plant
Tribulus terrestris
Spirulina is known
for being a good
source of protein
T IS FOR
TRIBULUS TERRESTRIS
The puncturevine, or Tribulus
V IS FOR
VITAMIN K2
Vitamin K is found in plants and is
terrestris, is a weed that produces important for blood clotting and
small spiky fruits. Extracts of these strong bones. K2 is the bacterial
fruits have been shown to increase form of vitamin K, and has similar
testosterone levels in rodents. This effects in humans when taken as a
doesn’t seem to happen in humans, supplement. There is good evidence
though. Studies have failed to show that it slows the rate of bone density
significant improvements in blood loss in the elderly, although less

testosterone levels or muscle mass. A effectively than hormone therapy in
few small-scale studies have shown a menopausal women. A few studies
limited improvement in male libido have also shown that high doses may
and erectile function. be helpful in treating liver cancer.
RATING 왎 왎 첸 첸 첸 RATING 왎 왎 왎 왎 첸
U IS FOR
UVA URSI
S
The bearberry plant, Arctostaphylos
IS FOR uva ursi, produces fruit that contain
SPIRULINA the hydroquinone compound
Made from dried blue-green arbutin. This is an antibacterial that
bacteria, spirulina is a good source of passes into your urine, and one study
protein (although it doesn’t contain found it can be effective against
any vitamin B12). There are some urinary tract infections, but there is
lab studies that have shown possible limited research into its effectiveness
immune system boosting effects, but in humans. Hydroquinones can also
these haven’t been replicated in cause liver damage in high doses, so
humans. One small-scale study using it for more than five days, or Arctostaphylos
found that spirulina was effective at more than five times in one year is uva ursi,
commonly
treating chronic arsenic poisoning. not recommended. known as
RATING 왎 왎 왎 첸 첸 RATING 왎 왎 첸 첸 첸 bearberry

W IS FOR
WHEATGRASS
Wheatgrass is simply the leaves of
the young wheat plant. It contains
roughly the same nutrient content as
the same weight of spinach or
broccoli. As a food, it’s fine, if a little
unpleasant tasting. As a medicine,
the evidence is very weak. Some
small studies have found that it
reduces the symptoms of ulcerative
colitis and the side effects of
chemotherapy, but most of the
claims that it rids the body of toxins
or oxygenates the blood are not
supported by science.
RATING 왎 첸 첸 첸 첸
American ginseng may

lower blood sugar and
boost the immune
system
Chromium in
Brewer’s yeast
is beneficial for
some diabetics
X IS FOR
XI YANG SHEN
Also known as American ginseng,
Y IS FOR
YEAST
Brewer’s yeast (Saccharomyces
Z IS FOR
ZINC
Over 300 enzymes in your body
both this and Asian ginseng contain cerevisiae) is a good source of require zinc to function. Dietary
chemicals called ginsenosides and selenium, chromium and B-complex deficiency is more common in
gintonin. Despite a long history of vitamins (but not B12 – that’s a vegetarians, because phytates present
use in Traditional Chinese myth). The most important in whole grains and legumes inhibit
Medicine, the evidence for health micronutrient is chromium. zinc absorption. Zinc supplements
benefits of ginseng is fairly weak. Numerous studies have shown that it seem to help protect against age-
Some small trials have found it helps type 2 diabetes sufferers by related macular degeneration
lowers blood sugar and boosts increasing their tolerance to blood (AMD), and conflicting evidence
the immune system, but claims glucose and reducing the amount of suggests it may reduce the symptoms
that it improves ‘wellness’, reduces insulin they need. There is also some of the common cold. But zinc can be
stress or acts as an aphrodisiac are limited evidence that it lowers the very toxic at high doses and interferes
not backed by well-designed LDL ‘bad’ cholesterol and raises with antibiotic medication, so use
scientific studies. HDL ‘good’ cholesterol. supplements with caution. ■
ALAMY
RATING 왎 왎 왎 첸 첸 RATING 왎 왎 왎 왎 왎 RATING 왎 왎 왎 첸 첸

HEALTH & FITNESS Bacteria

THE POWER OF
BACTERIAMicroorganisms are the perfect natural remedy to fend off
many a malady. NICOLA DAVIS reveals how these tiny
bugs protect your health – and even affect your mood
B
acteria. For many it’s role in immunity. In fact, you’ve that weighs about the same as a
a dirty word, been friends for a while. Most of human brain. And perhaps that’s
suggesting a your gut microbiota (including fitting, for while it’s long been
collection of invaders bacteria) initially came from your known that the brain can influence
to be obliterated with mother’s birth canal as you entered the gut, modern science is showing
a lemon-fresh spray. the world, or from skin and the that communication can go both
ILLUSTRATION: MAGIC TORCH
Yet the staggering surrounding environment if you ways. Indeed, recent studies have
truth is that you are more bacteria were born by caesarean. Once you’re revealed that the gut microbiota
than body – the gut alone holds over out in the open, multiple factors could be involved in a host of
100 trillion bacteria of myriad such as diet, antibiotics, genetics and conditions such as obesity, social
species, many of which help with stress will influence the microbiota. behaviour deficits, Parkinson’s
breaking down food and play a vital The upshot is a cornucopia of bugs disease and anxiety. That’s right – ´

Brain-derived neurotrophic factor (BDNF)

– a substance that affects the survival,
growth and connection of brain cells
microbes might be meddling with before and after bacterial derived neurotrophic factor (BDNF)
your mood. colonisation. Surprisingly, the protein – a substance in the brain that
It’s a hot topic of research that researchers found that the germ-free affects the survival, growth and
exploded just 10 years ago when a mice had greater amounts of stress- connection of neurons (brain cells).
team of Japanese researchers delved related hormones when restrained A wave of research involving
into the gut microbiota of mice. But than animals with microbes. Yet germ-free mice followed. One
these weren’t any old mice. They were when young germ-free mice were particularly intriguing study was
raised in a sterile environment, colonised by certain bacteria, their carried out by Dr. Jane Foster and her
therefore making them ‘germ free’. stress response changed. What’s colleagues from McMaster University
This created a clean slate with which more, the germ-free mice also showed in Canada. Using a cross-shaped
to study the brain and behaviour differences in the levels of a brain- maze, they found that germ-free mice
spent more time hanging out in
exposed areas than their bugged-up
Germ-free mice had greater amounts of peers. This suggested reduced levels
AYACOP, WIKI COMMONS
of anxiety, despite having increased

stress-related hormones when restrained levels of a stress-related hormone.
Furthermore, the germ-free mice
than animals with microbes showed changes to the levels of
BDNF-encoding molecules, which

ON TEST A germ-free mouse taking part in a study to monitor stress hormones, where
scientists compare time spent on the exposed and hidden parts of the cross-shaped maze
CROSS SECTION Confocal light micrograph of a section through a blood vessel in the
brain, showing the arrangement of cells that form the blood-brain barrier
suggests the gut microbiota might increase their anxious demeanour. young. If the same effect is observed
tinker with how the brain is wired for Nevertheless, the notion that in humans, it could imply a need for
anxiety. “We know what brain bugs can affect behaviour is pretty interventions in childhood and
regions are involved, and what’s mind-boggling. In one of the most pre-adolescence. Interestingly, the
interesting is those brain regions are astonishing studies, a team of composition of our own gut
changed in these manipulations of researchers transferred gut microbes microbiota is unstable until we reach
microbiota,” says Dr. Foster. from an anxious strain of mouse about three years of age. “It’s just
The interesting relationship into a germ-free mouse of a more developing, and that is also the same
between microbiota and behaviour, adventurous strain – and vice versa. period of life when the brain is
however, is far from simple. Changes The result? A behaviour transplant. developing,” states Professor Emeran
to levels of BDNF-encoding Mayer, a gastroenterologist at the
molecules appear to differ between Bugging out University of California, Los Angeles.
SCIENCE PHOTO LIBRARY / UCLA
sexes. Meanwhile, a recent study Yet questions abound, especially Interventions in elderly people
using one strain of rat found that the regarding the significance of age. might also be important because our
animals actually appeared to behave Indeed, some studies suggest that gut bacteria levels naturally start to
in a more anxious way when they stress responses and anxiety levels in decline as we age. “The microbiota
didn’t have gut microbiota. Studies germ-free mice can only be altered by composition, diversity [and]
have also found that infecting mice colonisation with bacteria if such abundance kind of reverses back to
with populations of ‘bad’ bacteria can exposure occurs when the animals are the way it was in childhood,” says ´

Various bacteria
species might Small but mighty
influence mood Most bacteria are just a few micrometres
in length – smaller than red blood cells
in humans
Bacteria are typically made up of just
a single cell each, but these cells are
very different to those that make up
Prof. Mayer. “So again it’s quite the human body. Bacterial cells do not
possible that any manipulations or have a membrane-bound nucleus. And
besides chromosomal DNA, bacteria
any influence on brain function will
can have ‘extra’ little loops of DNA
be greater at that time.” called plasmids. They also lack
Exactly how the gut microbiota membrane-bound organelles such as
bring about changes to the brain and mitochondria – the ‘batteries’ of our
behaviour is far from clear-cut. “If I own cells – and nearly all bacteria
have a headache it could be because I cells possess a cell wall.
Some bacteria are able to
bumped my head, or it could be harness light energy, while others
because I am dehydrated. Those make use of chemical reactions
are two very different mechanisms involving organic or inorganic
where the readout is the same,” says compounds to fuel processes in the
Dr. Foster. “It is the same thing here.” cell. Bacterial cells are typically just a
few micrometres (µm) in length.
And the mechanisms are myriad.
Lactobacillus cells, for example, are
Among the mooted possibilities, gut around 3µm long. Our own cells,
bacteria – or the molecules they however, can vary in size quite widely.
produce – could directly or Red blood cells are typically 7µm in
indirectly interact with branches of diameter. And ova, the largest human
the vagus nerve in the gut. They cells, can reach 120µm – roughly the
width of a human hair.
could signal to the brain, affect
hormonal signalling routes, interact
with the immune system, or trigger
responses via pathways that include
Lactobacillus Red blood cell Human hair
neurons within the gut lining and the 3µm 7µm 120µm
vagus nerve. What’s more, just a few
months ago, researchers revealed that 1 µm = 1 micrometre = 1 millionth of a metre
the gut microbiota could affect the
permeability of the blood-brain
barrier. It’s a web of intrigue. the animals more chilled out [and] and Lactobacillus species might
changed the brain chemistry,” influence mood in humans as well as
Mood swings Prof. Cryan explains. “When we cut rodents. In one trial, healthy people
“There are so many different types of the vagus nerve this didn’t happen.” given a blend of such probiotics for 30
bacteria and they are all having very But complexities are never far away. days were found to fare better in
different effects on different aspects “Some of our colleagues in Canada questionnaires probing anxiety,
of physiology,” says Professor John have done similar studies with depression and stress than those who
Cryan from the University of Cork. different bacteria and showed that were given a placebo. But that doesn’t
In one study, scientists at it wasn’t dependent on the vagus,” mean we should be stocking our
McMaster University joined forces he adds. shelves with probiotics just yet. “For
with Cryan and his team to probe the It’s a problem worth probing. me, taking a probiotic is like saying
impact of the probiotic Lactobacillus While human studies are few and far I’ll take a drug,” says Prof. Cryan.
rhamnosus on healthy mice. “It between, there is a tantalising “You might take a statin for cardio-
dampened down anxiety and made suggestion that various Bifidobacteria vascular disease, but you wouldn’t ´

MARTIN OEGGERLI
Intestinal bacteria help

us to digest food and
absorb nutrients

Gut feeling
Probiotics and prebiotics have alleged health benefits for us.
But what are the differences between them?
Prebiotics are substances that we through liquid drinks, yoghurts or ‘probiotics’ as the health claims
cannot digest, but are believed to tablets. Some of the most studied of such products have not been
promote ‘good’ bacteria in the gut. probiotics are of the genera approved, but manufacturers
Prebiotics occur naturally in some Lactobacillus and Bifidobacterium. are allowed to list the strain of
foods and include carbohydrates, The health benefits of probiotics bacteria included.
such as fructo-oligosaccharides, are specific to each strain and According to market researchers
galacto-oligosaccharides and inulin. different commercial products BCC Research, the global market
Probiotics are live microbes that contain different bacteria strains. for such products is expected to
are thought to bring a health Commercial products in the EU be worth around $36.7bn (£24bn)
benefit. They are often ingested are banned from using the label by 2018.
ALAMY

Prof. John Cryan studies
the effects microbes
have on our physiology
take it if you had depression – that’s

where we are with probiotics. We
need to get more precise about which
bacteria are doing what and why.”
Of mice and men

While it is still early days, Prof. Cryan
foresees a future of ‘psychobiotics’ –
probiotics that could be prescribed to
help treat people who are suffering
from mental health conditions.
Taking substances that promote the
presence of ‘good’ gut bacteria,
known as prebiotics, might also
prove beneficial.
“I think down the road there is a
lot of hope that people will, in
addition to getting their blood taken
when they go to their GP, also get a
quick snapshot of what’s going on in
their microbiome,” states Prof. Cryan.
That, he believes, could lead to the particular behaviour,” says Prof. the three groups in the connectivity
prescription of probiotics, perhaps in Mayer. “In humans, these layers of of various brain regions when resting.
parallel to various other treatments. prefrontal cortex can compensate and But when the women were asked to
Dr. Foster is cautious. “Until make up for it.” match images of angry or frightened
we have some evidence that the As Prof. Mayer has found, gut faces to similar pictures, the probiotic
microbiome is different in different bacteria do appear to have some group showed a decrease in the
mental health disorders – and how it impact on the human brain. In one activity of brain regions involved in
is different – we can’t really talk about small study funded by dairy product emotion and sensation. It was a
how relevant what we are learning in manufacturer Danone, Prof. Mayer’s surprise. “I didn’t expect it,” says Prof.
the mouse is to people,” she explains. team split a cohort of healthy women Mayer candidly. “I was a sceptic in
There are significant differences into three groups. One group was the beginning of all these animal
CLARE KEOGH, UNIVERSITY COLLEGE CORK
between mice and men, including the given a probiotic yoghurt, one a studies. They just seemed too
fact that the human brain boasts a probiotic-free dairy product and the outlandish – it seemed like it just
very different prefrontal cortex to that other nothing at all. The women’s didn’t fit into our paradigm of
of a rodent. This will affect the ways brains were scanned using functional brain-gut interactions.” But, he points
in which the gut microbiota may Magnetic Resonance Imaging out, there’s more to do. “It would be
function. “If your microbiota send (fMRI) at the start of the experiment, nice to repeat a study like the one we
a signal to lower lying brain areas, then again after four weeks of taking did, possibly in a population with
the mouse doesn’t have much to the intervention. The study found anxiety so that we can determine
compensate for that and it exhibits a that there were differences between [whether] these brain changes seen
with the probiotic are also correlated
with subjective changes in anxiety.”
“The probiotic group showed a decrease Just how big an influence microbes
have over our mood has yet to be
in the activity of brain regions involved in determined, but Prof. Cryan believes
we might be surprised. “It’s worth
emotion and sensation” considering that they are the master
puppeteers,” he says. ■

THERE’S NO
PLACE LIKE
HOME
Microbes don’t just affect our mood (see page 26), they’re
also key to keeping us healthy. TOM IRELAND reveals a
surprising picture of the bugs found around the home, and
how each family has its own personal zoo of bacteria
H
uman beings are looking at how the bacteria that genetic diversity of microbes in each
increasingly seen by we (and those that we live with) environment – its ‘microbiome’ –
scientists as walking deposit around us interact with and compare how genetically
microbial the buildings we inhabit. similar bacteria were to those
ecosystems. Our Researchers from the Home found elsewhere.
bodies contain Microbiome Project recently assessed The bacterial flora of each
about three times as the microbial communities household was so unique that
many bacterial cells as human ones, associated with seven families and researchers were able to
and we each deposit a unique blend their homes over six weeks, accurately match individuals to
ILLUSTRATION: ROBIN BOYDEN
of bacterial cells everywhere we go. including three families that moved their dwellings – even when
Microbiologists are only just to a new house. They found that we their ‘home’ was in fact a
beginning to understand how the quickly spread our own ‘microbial hotel room they’d
trillions of organisms that live in and signature’ throughout the places we only recently
on our bodies affect our digestion, live. By sequencing the DNA of moved into. Not
immune response and behaviour. bacteria in the home, the researchers only did all the
An emerging area of study is were able to create a picture of the houses contain ´

very different bacteria from each cleaning, the more bacteria they microbially similar to each other than
other, the study also showed that deposit. The best thing they could do those not sharing a home. The hands
when families moved, their microbial to reduce the amount of microbes in of young couples and couples with
signature quickly re-established itself their homes is not be there, says Lax: children were especially similar,
in the new location. “When you think of what people’s thanks to regular physical contact.
The reason our bacteria dominate homes are made from, they are But there’s one area of the body
the places we live is simply because mostly relatively new materials that where we are each more individual
there are few other routes by which bacteria haven’t evolved to live and – the nose.
bacteria enter those buildings. thrive on. These homes would “The nose is a fairly stable
“Almost all of the bacteria in the normally have quite a low bacterial environment that may be more
home can be traced back to the biomass until someone comes in.” unique to each person,” says Lax.
inhabitants,” says Simon Lax, a “But for places like the hand, it really
graduate student in the Department It’s a family affair comes down to what you’ve been in
of Ecology and Evolution at the Who we live with and what we do contact with, what you do for a living,
University of Chicago, and co-author also plays a key role in determining who you’ve met, and whether you
of the study. “If you have humans which bacteria take up residence in live in the country or in the city.
constantly coming into a home, then our homes. The study found that It’s more of a lifestyle thing than
they are the most common source people sharing a home are more anything genetic.”
of bacteria.”
Some studies suggest people now
spend between 22 and 23 hours a day
indoors – and nearly 70 per cent of Obsessive cleaners might want to re-think
that time is spent in our homes. All
that time at home might make you
their strategy: the study suggests that the
want to clean up. But obsessive more people potter around the house
cleaners might want to re-think their
strategy – the study suggests that the cleaning, the more bacteria they deposit
more people potter around the house

Although the bacteria found on
Trillions of microbes live
people and their homes were always in and on our bodies
highly correlated, houses were not
necessarily closely matched with the
bacteria of their pet. The presence of
a pet does, however, hugely expand
the diversity of bacteria found in a
BIOLOGY & BUILT ENVIRONMENT CENTER/UNIVERSITY OF OREGON/CAMERON SLAYDEN/COSMOCYTE
home. Samples from homes with pets

contained more proteobacteria, a class
of microbe that contains many
well-known pathogens including
Salmonella and E. coli. While that
may sound like a bad thing, the more
we understand microbial diversity the
more we find that it helps us in more
ways than it harms us. Exposure to
varied bacteria at a young age is
important for the development of a covered head to toe in this strange for how long bacteria survive in the
healthy immune system, for instance. microbial mixture, but that it might home, and also how to eradicate
“It’s not really a case of one house actually be a vital part of a growing them. This new approach may
being more unhygienic than the family’s health. contribute towards a fuller
other,” says Lax. “But what we understanding of what a healthy
know isn’t good for babies and A new understanding home is – for example, what levels of
young children is only experiencing The Home Microbiome Project is one bacteria can help develop a healthy
the microbiome of their own of the studies to treat families, their immune system and what levels may
environment and the bacteria of their microbes, and their homes as complex constitute a health hazard. And it’s
parents,” he says. It’s a bewildering interacting ecosystems. Research has not just physical health where
concept – not only that we are traditionally focused on where and bacteria can do good – the ´

Microbial hotspots in our homes
Dish sponge/cloth (321,629,869)

Our perception of hygiene often bears little relation to the reality of what
microbes live where. Here’s a rundown of some of the most colonised areas
Kitchen
Countertop sink
Stove Cutting
knobs
14%
board
18%
32% 45%
Percentage of
homes where
coliforms (faecal
bacteria) were
found on Dish
kitchen items sponge
77%
3X
more bacteria are in the human digestive
tract than there are cells in the human body
1.5ml of human saliva has 150 million bacteria – equivalent to
the amount found in one litre of Thames water
An iPad may house MICROORGANISMS ON

30 times more HOUSEHOLD OBJECTS
Staphylococcus The microorganisms found
Coffee reservoir
aureus, the bacteria included Staphylococcus aureus,
Tennis ball/pet toy
that can cause MRSA, 100,000 yeasts, moulds, and coliforms

than a toilet seat such as E. coli and Salmonella,
Kitchen sink
80,000 as measured by the US National

Tap handle
Concentration of microorganisms per 10cm2
60,000 Sanitation Foundation

40,000
20,000
One sneeze
can increase 10,000
the amount of
Countertop
1,000
Staphylococcus
Stove knobs
aureus in the air 800

Toilet seat
Gear stick
nearly fivefold 600

400
Chopping board
200
Toilet handle
100
Pens
1,000,000,000,000 80
Keyboard
iPod
60
40
Money
bacteria are harboured on human skin,

which is 3 per cent of the total number 20
of cells that make up the human body 0
Household object

Microbiome Institute at the Only experiencing the microbiome of their
University of Cork, in Ireland, have
linked bacteria to reduced stress and own environment and the bacteria of their
better memory (see page 57).
Back at the Home Microbiome parents isn’t good for babies
Project, the team’s next aim is to scale Simon Lax, Department of Ecology and Evolution at the University of Chicago
up its investigation and survey the
microbiome of hospitals. “We are
now taking this approach and
applying it to environments where the some bioscience companies believe wherever they go. “I’m not grossed
health implications are much higher,” sprays containing ‘good bacteria’ out by it, but it definitely makes you
says Lax. “We’ve seen hospitals with may be a more effective way of think. Am I leaving my signature
identical layouts and identical preventing dangerous human behind when I visit this house? Am I
cleaning methods, so it can only be pathogens from taking hold in changing what bacteria live here?”
the different people that affect the certain places. In time, maybe we will all come to
bacterial samples found there. And More projects measuring the see our house’s bacteria not as dirty
in a hospital environment, there impact of microbes in the built intruders, but welcome guests –
really are such things as good and environment are planned. Some even perhaps even tiny members of our
bad microbiomes.” involve architects, who hope that extended family. On the sofa tonight,
As our understanding shifts from a future buildings can be built to sit back and relax in the knowledge
fear of all bacteria to recognising their encourage a healthy microbiome, or that it’s just you, your family, and a
role in ecosystems, our approach to species that absorb pollutants. trillion bacteria that seem to enjoy
tackling infection is likely to change. For Lax, the results of his study your company in particular.
Attempts to simply wipe bacteria have opened his eyes to the unseen It’s true what they say – there
away seem increasingly futile. Indeed, microbial mark humans make really is no place like home. ■ ´

HEALTH & FITNESS Exercise
EXERCISE
A cure for all ills
Our ability to run, ride, swim, and play sport offers us a
wealth of health benefits. ROB KEMP looks at how it can
combat many physical and psychological ailments
P
erhaps the best immunity to illness are just some to. As a result, rest and
advertisement for the of the conditions from which recovery are as vital to
natural ‘cures’ science says a regular workout can ensuring exercise is effective
exercise can provide save us. in the long term. Always
comes in the shape of As an increasingly convenience- seek out expert advice or
the warnings we get focused, sedentary lifestyle becomes talk with your doctor.”
if we abstain from the norm for too many, the need to The key is to get the right
regularly breaking into a fitness- get active has never been greater. balance – pushing your body
focused sweat. But Professor John Brewer, Head to achieve the best results from
Depression, obesity, lethargy, heart of the School of Sport, Health and the natural benefits exercise has to
disease, insomnia, dangerously high Applied Science at St Mary’s offer, while also giving it time
levels of fat around the internal University in London, warns: to recover.
GETTY IMAGES
organs, impotence, breathing “Listen to your body. Exercise is So what exactly will exercise do to
difficulties, poor concentration, about adaptation, you put your body cure your ills? And how? Find out on
low self-esteem and a weakened through stresses that it has to adjust the next few pages... ´

The Secrets of Natural Remedies41
Hit the highs

Running has been shown to release endorphins and aid with sleep
Beyond the positive influence release of natural opiates. “The numb pain, like opoids such as
exercise has upon the body’s ‘runner’s high’ as we now know it morphine or codeine,” adds Dr.
strength, fat reduction and overall stems from the creation in the body Herbert. As a result, exercise
function, exercise can trigger a of endorphins, designed to ease and the release of endorphin
series of chemical reactions that pain in the body.” substances, such as
influence the body’s hormonal Although the ‘sweet spot’ for endocannabinoids, may contribute
response and boost the brain in endorphin release is commonly said to pain relief and relaxation.
many ways. to be a comfortable-to-hard effort And for those of you who are
“One of the most widely run, Herbert points out that many reading this in bed and not feeling
acknowledged benefits is the forms of exercise can trigger the sleepy, the next time you’re
‘runner’s high’,” explains Dr. Peter ‘high’. Research from Oxford struggling to get a decent night’s
Herbert, a physiologist at the University even found that simply sleep, it’s worth knowing that
University of Wales Trinity exercising in groups raised the donning your running shoes can
Saint David. Back in the 1990s, release of endorphins quicker for make a huge difference. A number
GETTY IMAGES
researchers began to identify links some than exercising alone. of studies confirm that sleep quality
between exercise and feelings of “These endorphins are opoid for insomniacs can be made a
euphoria that stem from the neuropeptides – chemicals which whole lot better with more exercise.

Keep your heart healthy
Walk a minimum of 150 minutes a week to lower your risk of heart disease
As the body adapts to the demands developing the capillaries, easing contributor to cutting cardiovascular
exercise puts upon it, other health constrictions in peripheral disease, which is one of the leading
remedies become apparent. circulation, and reducing the causes of death in the UK.
Hypertension, or high blood pressure,” says Professor John Getting at least 150 minutes a
pressure issues, can be combated Brewer, Head of the School of week of moderate-intensity aerobic
through exercise. “Aerobic activity, Sport, Health and Applied Science activity can lower your risk of heart
even at moderate levels through at St. Mary’s University in London. disease, reports the American Heart
regular walking, has been shown to It’s just one example of how Association – while also improving
trigger vascular adaptations, exercise can be a significant your cholesterol levels.
Defend against depression

Exercise stimulates the production of mood-lifting serotonin
Studies reveal that significant improvements A polarized light

exercise can reduce stress in self-esteem and micrograph (PLM) of the
and have longer term mood, along with fewer neurotransmitter serotonin
effects on one’s mood. incidents of depression
Over time, the hormonal among people who
response that exercise exercise outdoors.
triggers is an effective “For many people
treatment for depression. exercise and the positive
Research published in the impact it has upon the way
Journal of Psychiatry and you look can also be a
Neuroscience shows raised remedy for melancholy,”
GETTY IMAGES / SCIENCE PICTURE LIBRARY
levels of tryptophan in says Professor John

athletes, especially in Brewer, Head of the
endurance runners – School of Sport, Health
that is an indicator of and Applied Science at
raised levels of a mood- St. Mary’s University in
elevating neurotransmitter London. “Studies confirm
known as serotonin. it can contribute to curing
Psychology specialists low self-esteem, especially
at the University of Essex among those who work
have also recorded out with a team.”
´

Beat brittle bones

Regular bone and muscle strengthening
exercise slows bone density loss
“The ageing process can health issues, such as a

take its toll on your bones, hip fracture, making sure
joints and muscles,” you’re doing moderately
explains physiologist intense walking for 120 to
Dr. Herbert. 300 minutes a week will
Medical conditions such cut your risk.
as arthritis of the joints Exercise has been
and a natural depletion of shown to help in the
bone density put us at prevention of arthritis and
greater risk of serious other conditions affecting
injury if we have accidents the joints, such as gout
such as falls. and osteoarthritis.
But simply taking part Research also shows
in routine bone and low-impact aerobic
muscle-strengthening activity can help those
aerobic exercise can slow suffering with joint
the loss of bone density as conditions to better
we age. For age-related manage their pain.
Keep it up
Sexual function, and problems such as impotence,
may be given a helping hand by regular workouts
Research from the US and occuring,” explains

Nigeria shows that for Professor John Brewer,
men with erectile Head of the School of
dysfunction, aerobic Sport, Health and Applied
exercise can provide a Science at St. Mary’s
natural alternative to the University in London.
little blue pills. Psychological issues,
“Certainly major such as low self-esteem
components in the causes and high levels of
of impotence can be stress, are also given as
physical – with a reasons for impotence –
sedentary lifestyle often something exercise can
cited as a risk factor in it also help.
ALAMY / GETTY IMAGES

Exercise may reduce the
risk of colon cancer by as
much as 25 per cent
Combat disease
Exercise can help in the fight against cancer and diabetes
Running, walking, cycling or Exercising at a moderate intensity impact it can have on reducing
playing an active role in team for 120 to 150 minutes a week has colon cancer in men and women
sports can provide a natural been shown to reduce these risk may be as high as 25 per cent.
medicine to ward off type 2 factors in a series of studies. Although studies continue,
diabetes and metabolic syndrome Research also reveals how there’s some suggestion that a
– a condition with symptoms that exercise is becoming key to person’s risk of endometrial cancer
may include too much fat around reducing the risk of some cancers. and lung cancer may be lower if
the waist, high blood pressure, low Regular physical activity was found they get regular physical activity
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HDL (good) cholesterol, high to reduce the risk of breast cancer when compared to people who are
triglycerides or high blood sugar. in women by 12 per cent, while the not active.
´

Fend off fat

Exercise burns calories, which inevitably aids in weight loss,
but running also stems the production of the ‘hunger hormone’
One of the most apparent remedies done regularly enough – was as levels you need to create a calorie
exercise can bring is around weight good as gym training for those deficit – burning more calories
loss and weight management. looking to lose or maintain their than you consume. To burn off
A whole host of research, weight. Interestingly, a study of 2lbs of fat costs around 8,000-
including studies from the Journal 50,000 patients between 1999 and 9,000 calories.”
of Applied Physiology, highlight how 2012 found that those who walked Running a marathon will only
a combination of aerobic exercise regularly had lower body mass hit around a third of that figure.
and resistance training (using indexes (BMIs) than patients who By creating a daily deficit of 500
weights, machines or bodyweight took part in high-intensity exercise. calories, through heart-rate raising
to train muscles) can have a Although the results aren’t and exercise and controlling your
positive impact on fat levels and shouldn’t be immediate, regular calorie intake, you can make
waist circumference among exercise in conjunction with a serious in-roads into your body
overweight subjects. Resistance managed, balanced diet has been fat percentages.
training has been shown to shown to be the safest, more Researchers from the
contribute to the development of effective means of shedding fat University of Western Australia
muscle mass, changes in body and keeping it off. have also found that running
composition and fat reduction. “The body fuels exercise with contributed to weight control
Just moderate intensity aerobic energy drawn from within – from by regulating appetite. Runners
activity, such as walking, can make blood sugars and body fat,” performing interval sessions in
serious in-roads into weight loss, explains Professor John Brewer, a trial reported fewer cravings
too. In one of the most recently Head of the School of Sport, Health for snacks as a result of the
published studies, from the London and Applied Science at St. Mary’s exercise regime curtailing the
School of Economics, researchers University in London. “In order to production of ghrelin, nicknamed
found that brisk walking – when lose weight and reduce body fat the ‘hunger hormone’.
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Stay sharp
Exercise keeps us mentally fit too
Aerobic exercise, or a of Sports Medicine, and

combination of aerobic another presented at the
and muscle-strengthening 2015 Alzheimer’s
activities, three to five Association International
times a week for 30 to 60 Conference, found that
minutes can help maintain both regular aerobic
learning and keep exercise and some
judgement skills sharp. forms of resistance
Meanwhile, natural brain training improved
reactions to exercise have hippocampus-related
been shown to protect us memory, and slowed
from forgetfulness, and down cognitive decline.
improve problem solving A study from the
and thought processes. University of Montreal
Recent research even noted that those of us who
suggests that exercise use the weight room to
throughout one’s lifetime build muscle may be giving
can play a major role in the brain a lift, too. The
battling the onset of study suggests that the
age-related ailments, raised levels of growth
such as dementia. Several factor 1 (IGF-1) caused by
studies, including one resistance training helps in
from Japan published in neuron (brain cell) growth
the International Journal and longevity.
Natural exercise supplements

Dr. Emma Derbyshire, an expert in nutritional physiology at Manchester Metropolitan
University, reveals natural exercise supplements that can make your workout more effective
CAFFEINE CHERRY JUICE RED MEAT PROTEIN

A natural stimulant found Cherries are a great source (Iron) (Essential amino acids)
in tea, coffee, cocoa and of antioxidants, including Lean red meat is an Protein is needed during
colas, caffeine has long vitamins A and C, as well as important source of exercise to offset muscle
been known to enhance anthocyanins – red, blue essential nutrients, wasting, which can occur
GETTY IMAGES / ISTOCKPHOTO
performance. Lower doses and purple pigments which including iron, zinc and when protein intakes are
of caffeine (about 200mg have potent antioxidant energy-yielding B-vitamins. inadequate. High-quality
or <3mg per kg body mass) properties. Drinking cherry Female endurance runners protein, such as that found
are thought to help juice, which contains these in particular are vulnerable in fish or red meat, can
improve alertness, mood components, may help to to iron deficiencies, and so help to maintain muscle
and concentration during reduce inflammation and should try to include lean size and strength,
and after exercise, with few ease muscle soreness red meat regularly within particularly when combined
if any adverse side effects. after exercise. their diets. with resistance training. ■

HEALTH & FITNESS A Helping Hand
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A HELPING
HAND
Months of queasiness, topped off by a 24-hour (plus) labour.

Many mums have had to deal with the hardships of
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pregnancy, followed by a harrowing birth. ZOE CORMIER

investigates natural ways to make the experience easier
´

Research suggests that water birth might

facilitate women to have a birth without
J
ust imagine pushing an
object the size of a interventions, such as an epidural
watermelon through Ethel Burns, Senior Lecturer in Midwifery at Oxford Brookes University
the most sensitive part
of your body. Labour
could take hours, even
days. Sound terrifying? pregnant women are treated with and other positions at prenatal yoga
For many women – and their partners white gloves, so they go into labour classes. This ancient practice has been
– the anticipation of childbirth can thinking they’re fragile and not shown to have a number of health
be scary. This fear can make the appreciating how strong they can be.” benefits (see page 80), and a recent
experience more painful by Most practitioners who teach study by Japanese researchers found
enhancing anxiety and muscle ‘alternative’ methods to overcome that prenatal yoga can help expectant
tension. It’s a complex interaction labour pain, which don’t involve mothers – reducing pelvic pain
between the mind and body during epidurals or other drugs, advocate during birth by preparing the
an incredibly intense experience. finding ways to quell adrenaline and abdominal muscles for labour.
“In mainstream medical fear with a variety of tactics. From Of course, once it gets to the actual
treatment, pregnant women tend to hypnobirth to birthing pools, they birth, muscle control becomes key. As
have quick check ups that examine are increasingly popular, and a far cry labour kicks in, contracting certain
the physical state of them and their from women simply lying flat on their muscles while relaxing others is a
baby, but don’t usually prepare them backs in front of doctors wielding delicate tango between exertion and
for the actual event – physically and forceps. But do they work? agony. Studies show pain is reduced
mentally,” says Emily Koehler, a during labour if a doula or birth
so-called ‘doula’, who gives support Ancient practices partner massages the perineum (the
and advice to women during Many mums-in-waiting prepare for region between the thighs and the
pregnancy and birth. “Traditionally, battle by striking the warrior pose, pelvic diaphragm) or carries out
acupressure, as shown by research
published in the journal Acta
Obstetricia et Gynecologica. But,
others recommend more exotic
techniques to limber yourself (and
your baby) into the right position.
“One of my favourite tools is the
‘rebozo’,” says Nici Shipway, a mother
and doula based in Toronto, Canada.
This traditional South American
shawl can be wrapped around the
mother’s belly to help open the
hips, and give a relaxing cradling
movement. “It’s not only soothing for
the mum, it helps move the baby into
the right position.”
Hot water
Riding out contractions – or giving
birth entirely – in a shallow, warm
pool is increasingly popular.
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STRIKE A POSE Understandably so. Who doesn’t

Practising prenatal yoga can enjoy chilling out in a hot bath at the
reduce pain during labour
end of a long day? So, for expectant

WATER BABY
Birthing pools reduce the
amount of drugs a mother
needs during birth
mums the psychological familiarity have shown that water births require newborn babies, due to faecal matter
adds to the soothing qualities of the less pharmacological relief, cause less spilling into the pool, but studies of
warm water, while the buoyancy tearing of the perineum, and provide water birth (at least, in developed
helps with back and muscle pain. greater maternal satisfaction and countries) found no evidence of
“In the UK, birthing pool use a higher chance of spontaneous increased rates of infection. An
during labour is now a mainstream birth. This has been proven – not Italian study, published in 2014,
practice,” says Ethel Burns, Senior only by Burns’ own study of almost which looked at the experiences of
Lecturer in Midwifery at Oxford 8,000 women, which was published more than 2,600 women found “clear
Brookes University, where water in the journal Birth in 2012 – but also medical advantages”, including
births are a standard treatment in a study of more than 31,000 “significantly shorter labour duration,
available in the NHS. “There is women from several countries, a net reduction in episiotomy rates;
research to suggest that water birth published in the Journal of Midwifery and a marked drop in requests for
might facilitate women to have a and Women’s Health in 2014, pain relievers.”
birth without interventions, such as which found the potential risks to But, inevitably, there are
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an epidural.” be ‘minimal’. some possible risks. “Although

Numerous randomised controlled There are some fears that water observational studies haven’t shown
trials and observational studies birth could lead to infections in an association between water birth ´

and extensive perineal trauma, some

clinicians express concern that it may
predispose women to this outcome,”
says Burns, as shown by an American
study published in the Journal of
Midwifery and Women’s Health in
2016. This is a real concern, but the
jury is still out. As Burns points out:
“One way to study this would be
using randomised controlled trials.”
Mind control
Another one of the most popular new
treatments to ease pain is the widely-
hyped ‘hypnobirthing’. Often termed
‘self-hypnosis’, the technique involves
a mixture of breathing exercises,
visualisations and meditative
practices to calm the body, and break
the ‘fear-tension-pain’ cycle. In other
words, mind over matter – if the
mind can create anxiety, and anxiety
can create pain, quelling mental noise
can reduce pain.
Proponents of hypnobirthing RELAX AND BREATHE
claim that not only can it reduce pain A group learns hypnobirthing
techniques in preparation for labour
and the use of pain-quenching
epidurals, it can also shorten the
duration of labour. understanding of how the body and bypass their fears and biologies with
“It’s about getting the mind out of hormones work, and how to use the generic hypnobirthing
the way, so that the body can do what mental and physical tactics to reduce programme,” says Toronto-based
it was designed to do,” says Kate your own pain, can give you an Tanya Pillay, a certified hypnotist,
Johnson, who is based in the UK, and enormous amount of confidence, who signed up for hypnobirthing for
trained to become a professional which in itself will help make the her own pregnancy five years ago.
hypnobirth therapist after using the experience more positive.” “While I appreciate the impetus to
technique during the birth of her first Many women have found that radically modify the mind, it’s a lot to
child. While Johnson never tells her hypnobirthing dramatically helped ask an expectant mother not to use
clients that hypnobirthing guarantees with the pain. But many others report the words ‘pain’ or ‘contraction’.
a pain-free labour, she feels the that the technique ceases to work in Referring to the sensations as
training and knowledge will the final throes of labour. ‘discomfort’ and ‘surges’ just wasn’t
invariably help. “Having a greater “Not every woman is able to realistic for me.”
As with all new birthing
techniques, some sing the praises of
Mind over matter: if the mind can create hypnobirthing, while others feel the
hype is overblown. So what does the
anxiety, and anxiety can create pain, science say?
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“The problem is that the labour

quelling mental noise can reduce pain ward is a difficult environment to
relax in,” says Soo Downe, Professor

TAKING CARE
Empathetic assistance
from a caregiver is known
to help mothers give birth
in Midwifery Studies at the ‘regression to the mean’ – things even programme for pregnancy, I would
University of Central Lancashire. out to the middle and you don’t see a teach a birth partner how to be a
“But there definitely is physiological huge effect at the big scale.” hypnotist for the mother, with a
evidence that hypnotherapy works.” customised series of hypnosis sessions
Last year, Prof. Downe published What’s in a name to address the mother’s personal
the second largest randomised Most practitioners and researchers fears, beliefs, values and preferences
controlled trial of first-time mothers would agree – part of the problem in when applying metaphors and
taught self-hypnosis or another popular misunderstandings of the relaxation techniques.”
standard therapy. The results, therapy lie not in the technique, but Which gets to the heart of all birth
published in the British Journal of in the name. Hypnobirthing is not a therapies – figuring out what works
Obstetrics and Gynaecology, showed form of ‘hypnosis’ as most of us for the individual and customising all
that of the 680 women involved in would understand the term – nobody the tactics for each mother.
the trial, those given hypnobirthing snaps their fingers and puts you into “Of all the therapies, the one we
training requested an epidural 27.9 an otherworldly trance. Some think have the strongest evidence for is the
per cent of the time, compared to it should be called ‘meditative birth’, continuity of the relationship the
30.3 per cent of the control group but even that label doesn’t quite mother has with their caregiver,” says
– not a huge difference. hit the mark. Prof. Downe.
“For some women, hypnobirthing For her part, Pillay thinks that In other words: massages, mantras,
GETTY IMAGES
absolutely does work, but not for there should be a genuine form of mind control – it can all help, but in
others,” says Prof. Downe. “So in big hypnotic therapy for birth pain. “If this most primal of acts, it’s the
population-based studies, you see a I were to write my own hypnosis human contact that is key. ■

HEALTH & FITNESS Stress Busters
20 STRESS
BUSTERS
Over half of us now face the crucible of urban commutes,
increased working hours and less job satisfaction. With things
only set to become more stressful, ALEX HARRIS explains
how it’s time to take matters into our own hands

S
tress is a delicate Americans report feeling more fraternity are utterly at odds –
balancing act. On its stressed now than five years ago, from acupuncture to supplements,
tightrope wobbles while stress causes 75 per cent of expensive retreats to extensive
your health and all doctor visits, according to the books, contrasting studies abound,
happiness – stay US Centers for Disease Control conflicting opinions more so. It’s
surefooted and it’s a and Prevention. On these negative enough to give you a stress-induced
useful tool, but push effects the medical science migraine. Perhaps take some witch
too hard and stress can tip the community can agree. hazel for it. Actually, don’t. Try these
balance and your body toward some But scientists are in less accord study-backed remedies instead.
ghastly diseases you definitely want to when it comes to the sure fit of Stress is a subjective experience.
GETTY IMAGES
avoid. In chronic amounts, it flattens so-called cures, of which you To the men and women in white
your mental faculties and increases have probably seen, and indeed coats, these are objectively the
inflammation. Around 44 per cent of tried, many. In fact, the medical best cures. ´

2 Listen to some
aural medicine
Stress can be a killer, but rock music can keep you
off the stairway to heaven. In a recent study into
the mental effects of head bangers, scientists at
the University of Queensland, Australia, discovered
that, contrary to accepted wisdom, heavy
metal music can help you regulate
emotions, such as anger and
sadness. You don’t have
to go full emo – a
10-minute session
is all it takes to
get back out
1 Get a pet
If work stress has you chewing the carpet, fret
not – Fido has your back. Coming home to a faithful pet
can de-stress you, curb blood pressure, and encourage
the release of feel-good hormones, such as dopamine.
of black.
That’s according to research in the Journal of

Psychosomatic Research. Even some law schools in
America are bringing puppies in for ‘cuddle days’ to
help students deal with the rigmarole of their final
exams. Which is a smart rule, if you ask us.
3 Take a hike
You don’t need scientists to tell you that taking
a walk in nature can help boost your mood and reduce
negative feelings. But scientists at the University of
Michigan, in the US, decided to prove it anyway. Their
follow-up research was more interesting. They found
that even looking at a picture of nature, or some trees
or plants, can reduce cortisol and improve your mood,
even more than a walk in an urban area. Google
Images just became your new RX.
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5 Block out
After a severely stressful
event, loading up
Tetris® on your
phone can keep
the event from
sticking in your
memory, while
also reducing
the risk of it
re-emerging as
post-traumatic
stress further down
4 Take a tea break

Emulate the Brits and put the kettle on
during times of difficulty. A study by City University
in London found that, when placed in a stressful
situation, test subjects denied a cup of tea showed
the line. That’s
because focusing on
a highly engaging
visual task can
override your visual
memory, blocking out
what would otherwise
a 25 per cent increase in anxiety, while those force its way in
allowed a brew actually enjoyed a four per cent permanently. The
reduction. Aside from the benefits of the calming research from Oxford
amino acid L-theanine, abundant in tea, the ritual of University is being
making the tea itself was found to be beneficial. utilised by everyone from
Milk is optional. the military to regular civvies.
Best fall in line.
7 Get dirty with bugs

The so-called ‘microbiome’ of bacteria
living inside each of us has been linked
with everything from risk of disease to body
composition. Now, bacteria-loving scientists are
arguing the case for probiotics as a stress reliever.
Having previously shown the strain Bifidobacterium
longum 1714 (try getting your mouth round that) to
have a mitigating effect on anxiety, the Microbiome
Institute at The University of Cork, Ireland, have
now linked it to reduced stress and better memory.
6 Play mind games

If Tetris® isn’t your thing, more conventional
video games might be. And that’s no bad thing. A study
co-authored by two graduate students (why aren’t we
surprised?) from the University of Wisconsin, US, showed
that violent video games were a quick-fire solution to

stress. Watch your dosage, though, as too much can
increase the likelihood of you reacting aggressively.
Short bursts on your daily commute are best, which a
separate study at McGill University, Canada, found
reduces the stress hormone cortisol by 17 per cent. ´

8 Enjoy a cup
of coffee
If you prefer your hot drinks black
with a crema floating on top, then
don’t change your habit just yet.
Coffee could be a stress reliever.
While an excess of caffeine will give
you the jitters, an international
team of researchers found that
mice exposed to a certain amount
of caffeine prevented adenosine
receptors in the brain from reacting
to stressful situations. So, if this
also works for humans, your arabica
could help combat stress during a
tough day.
9 Keep your cool

The Scandinavians do a lot right when
it comes to health – they eat lots of fish, walk
everywhere, and ski like the ice is running out.
But it turns out their best trait is their collective
penchant for roasting away in a sauna. Published in
the journal JAMA Internal Medicine, one particular
paper reports some interesting findings. Sauna
bathing is associated with a reduced risk of
cardiovascular problems and all-cause mortality,
meaning that a stress-induced heart attack will be
off the menu if you bake yourself regularly.
10 Laugh it off
Perhaps you’re a highbrow satire fan or
maybe you just appreciate seeing someone fall over on
YouTube. Either way, that fit of laughter will fortify your
brain against stress. In the short term, it activates your
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stress response, then immediately calms you down, while

bringing in more beneficial oxygen. In the long run, a
regular guffaw has been shown to benefit your immune
system. No joke.

12 Take a breather
If your paperwork is piling up, just pause.
One of the most well-established stress busters is
actually internal. Harvard scientist Herbert Benson
created the idea of the Relaxation Response, and a
plethora of studies have backed up his notion. Slow,
rhythmic breathing calms your nervous system, allows
you to deal with mounting pressure, and can help bring
your to-do list back down to Earth.
11 Get creative
Perhaps you approach those mindfulness
colouring books with a drop of scepticism, but you can’t
argue with the recent findings of a San Francisco
University study. The researchers found that, mindfulness
aside, engaging in a creative pursuit out of work allows
you to better deal with challenging times while actually
improving your performance when back in the work-
place. Pick up the guitar or dig out your paint brushes
– it’s all beneficial to your brain.
13 Help others
Despite the fact that we’re focusing on
looking after number one here, it pays to take others
into consideration. That’s according to a study
published in Clinical Psychological Science, a journal
of the Association for Psychological Science, which
found that providing help to others – friends,
acquaintances or even strangers – protects your
mental health against the impact of daily stress.
Something as trivial as holding open a door for a
colleague can keep work pressure from getting in.
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14 Have a glass
of milk
Calcium has long been the friend of
the health conscious. But it’s good for
more than your bones. A study in the
Archives of Internal Medicine
discovered that milk is particularly
good for women who suffer from
stressful PMS symptoms. In
fact, those who drank four
servings a day saw their risk
of pre-period misery
plummet by almost half.
We’ll drink to that.
15 Do the washing up
Tough day at work? It’s your turn to do the
washing up. Extra chores might feel like self-flagellation
after an onerous 9-5 at the office, but in fact the
opposite is true. Florida State University scientists did
a load of extra dishes (we’re sure their partners were
pleased) to determine whether the contemplative and
uniquely tactile moment yielded any brain benefits. It
turns out that getting up to your elbows in bubbles calms
the mind and reduces stress hormones. It’s also likely to
induce boredom and a longing for Netflix, if you ask us.
16 Crack your noggin

The high-fat low-fat diet debate has been
grabbing tabloid inches lately. While many nutritional
scientists are at each other’s throats about what should
be going down them, there’s one dietary truth everyone
can digest – polyunsaturated fats from nuts are pretty
good for you. So good, in fact, that a daily serving of
walnuts can positively influence your blood pressure
under stress. So say researchers at Penn State
University, US, who tested the nuts and the nut oil on
22 people over six weeks before reaching these findings.
The fact that walnuts look like tiny brains must be Nature
trying to tell us something.
17 Find a bro
Depression and stress are so often
uttered in the same sentence. And yet, while the
former is wont to make you more insular and
reclusive, the latter is actually totally different and
might make you more social. A surprising study by
German researchers found that stressed men in
particular are more likely to seek out social
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bonding. Which is rather convenient, as quality bro

time has been found to mitigate stress hormones.

18 Clean up your act
Exercise beats stress. Not exactly
groundbreaking stuff. More surprising, however, is the
news that working up a sweat even when cleaning your
bedroom can improve your mood and reduce feelings
of depression. University College London researchers
studied 20,000 people and found that taking part in
sports cuts your risk of stress by a third, but vigorous
housework is enough to reduce the risk to the tune of
20 per cent. The researchers say to aim for a solid
20 minutes and your mind will be as clear as the floor.
20 Give a hug
We’re going to get all mushy for this last
tip. It’s accepted science that getting physical with a
regular hug from a loved one releases oxytocin, which is
why it’s known as the hug hormone. But there’s another
biochemical argument for wrapping yourself around your
housemate after a terrible day, which comes in the form
of anandamide. This one is known as the bliss molecule
on account of its link to happiness, and the fact that its
release feels similar to the effects of smoking cannabis,
according to University of California Irvine scientists.
That’s a high we can get behind. ■
19 Ditch social media

Facebook might make you feel more
connected but, in mental terms at least, the opposite is
true. A study by the Happiness Research Institute in
Copenhagen took a group of participants and had half

eschew the social media site. After just a week, the
offline half reported feeling happier, and less angry,
lonely and depressed. What’s more, people on Facebook
were 55 per cent more likely to feel stressed. So take a
break occasionally and your friends will thank you. ´

HEALTH & FITNESS Nature’s Pharmacy
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Nature’s
PHARMACY
Deep oceans, shallow seas and dense forests are
teeming with natural remedies, just waiting to be
discovered.HELEN SCALES dives in to reveal how
scientists are looking to the natural world for inspiration
COLOURFUL SEA SLUG

A nudibranch, Chromodoris
lochi, on the Tubbataha Reef in
the Sulu Sea, the Philippines ´

AROMATIC HERB
The sweet wormwood
plant, Artemisia annua,
used to make anti-
O
n a coral atoll in the malarial drugs
South China Sea,
300 miles off the
coast of Borneo,
I prepare for a
distinctly unusual
scuba dive. Among
my equipment are plastic bags, thick
rubber gloves and a large chisel –
not things I normally need while I’m
diving, but essential for what I’m
about to do.
I drift downwards through water
so clear it feels as if I’m flying. The
coral reef stretches out below me like
a flourishing garden, every centimetre
packed with life. Nearing the bottom
I prepare myself to shake off a deeply
ingrained instinct: look but don’t
touch. It’s a rule I usually stick to, not
only to avoid upsetting the fragile
wildlife, but also for my own sake.
Plenty of things on a coral reef
will bite or more likely sting me.
To survive in such crowded
neighbourhoods, reef creatures have
evolved many means of attack and
defence, often involving potent
chemical warfare. It’s one of the
chief reasons why these bustling
ecosystems are a focus for so-called
‘bio-prospecting’.
Many important Western medicines have
For several decades scientists have their origins in the natural world, such as
been searching reefs for novel
molecules that could form the basis aspirin from willow tree bark
for new medicines. The first step in
the process, and my task on this dive,
is to gather samples.
Bristol University. He’s one of many from Nature is an idea grounded in
Inspired by Nature scientists tapping into the treasure centuries-old traditional remedies
From fungi that grow in the fur of trove of complex compounds that made from plants and animals, and
three-toed sloths to a sea snail’s have been evolving in the wild for it’s been an immensely successful
sleep-inducing sting, mud from deep millions of years. Known as natural approach. Many important Western
ocean trenches to a Gila monster’s products, these can be almost medicines have their origins in the
SCIENCE PHOTO LIBRARY
drool, there’s no saying where the anything with the potential to natural world – aspirin from willow
drugs of the future might come from provide antibacterial, antiviral, tree bark, the chemotherapy drug
– all are distinct possibilities. anti-inflammatory, anti-cancer or Taxol from Pacific yew tree bark, and
“Nature is the greatest chemist,” any number of other health benefits. cholesterol-lowering statins from
says Dr. Paul Race, a biochemist from Seeking medicinal inspiration strains of soil-borne fungi.

CANCER WARRIOR
The sea squirt Ecteinascidia
turbinata is a source of the
anti-cancer drug Ecteinascidin,
as found in Yondelis
In 2015, three scientists were themselves to the solid structure of

awarded the Nobel Prize in medicine the reef and don’t move, creatures
for their natural product discoveries. such as sea squirts and sea sponges.
Chinese chemist Tu Youyou isolated Carefully, I scrape them off, one by
the powerful anti-malarial drug, one, into plastic bags.
Artemisinin, from the sweet Sedentary creatures like these have
wormwood plant. Professors a proven track record in the search for
William C. Campbell and Satoshi new medicines. Back in 1969, the US
Omura together discovered Food and Drug Administration
Avermectin, based on strains of approved cytarabine as an anti-cancer
NATURE PICTURE LIBRARY / GETTY IMAGES
bacteria, which combat river treatment. It was one of the first

blindness and elephantiasis. drugs inspired by marine creatures,
Altogether, in the last 30 years, this one based on extracts taken from
around half the newly released sponges growing on reefs in the
medicines have been based on natural Florida Keys. Other reef-based
products, including plenty that were medicines include Prialt, a powerful
found on coral reefs. painkiller developed from the deadly
Prialt ziconotide is a non-
Back in the South China Sea, I addictive painkiller, derived from sting of a cone snail, and Yondelis
zero in on gelatinous animals that fix the cone snail, Conus magus which was discovered in a Caribbean ´

NEON SEA SLUG

The nudibranch Nembrotha
kubaryana in Triton Bay,
Papua New Guinea
GETTY IMAGES

Molecules that are
powerful enough to
deter hungry
predators often turn
out to be lethal to
cancerous cells too
sea squirt and FDA-approved as a

chemotherapy agent in 2015. Clinical
trials are underway for dozens more
natural products from coral reef
creatures, and not only the ones that
stay put.
Brightly coloured sea slugs, also
known as nudibranchs, that glide
around coral reefs have shown
themselves to be a fruitful source of
novel molecules. Without a shell for ‘CONAN THE BACTERIUM’ Deinococcus radiodurans got this nickname due to being one
of the toughest bacteria on the planet – and hence a potential source for powerful new drugs
protection, these relatives of sea snails
instead load their tissues with
bad-tasting, noxious chemicals to than from cancer and diabetes put from these remote, harsh places can
ward off attack – their colours are a together. On the flip side, bacteria be challenging. Manned submarines
stark warning of what lies inside. could also provide solutions to this can venture into the depths, but at
Molecules that are powerful enough growing problem. huge cost. A cheaper option is to
to deter hungry predators often turn Many research teams are turning deploy so-called ‘mud missiles’,
out to be lethal to cancerous cells too. to the enormous and largely 1.8m-long probes designed to plunge
Sea slugs don’t produce these anti- undiscovered diversity of bacteria, into the ocean floor and bring back
predatory compounds themselves, especially those living in extreme mud samples. And it seems to be well
but acquire and accumulate them environments where life is tough, like worth the effort.
from their food, mainly seaweeds and in the deep sea, at the freezing poles Prof. Jaspars describes deep sea
sponges. Researchers are also starting or in scorching deserts. These trenches as ‘negative islands’ that
to realise that many new chemicals ‘extremophiles’ commonly evolve an reach down into the ocean, instead of
being found among coral reef arsenal of complex compounds to up. Each isolated chasm is potentially
dwellers are in fact made by bacteria survive, outcompete and ultimately home to its own pool of microbes that
living inside them. kill each other. have evolved unique chemicals.
Bacteria have become a major “It’s really these unusual or novel “At the moment we have around
focus for natural product research for natural products that we’re chasing,” 13,000 or 14,000 different bacterial
two key reasons. First is the rising tide says Dr. Race. strains,” says Prof. Jaspars. These were
of drug-resistant ‘superbugs’ – isolated from deep sea mud across the
bacteria that can no longer be treated Deep search globe, including off Antarctica,
with standard antibiotics. It’s thought Professor Marcel Jaspars is project China, Chile, New Zealand and
that unless new medications are leader at PharmaSea, an international South Africa. “We’re trying to figure
developed, and soon, the annual research team hunting for new out which are the high value ones,”
death toll from untreatable infections antibiotics in the seas, in particular says Prof. Jaspars. “The ones that are
could rise to 10 million people from deep oceanic trenches. actually doing interesting things.”
worldwide by 2050 – more deaths Getting hold of microbe samples Routine screening involves taking ´

Deadly cone
snails under threat purified extracts from lab-grown
bacteria and testing them against a
suite of pathogens. Prof. Jaspars’ team
The lethal creatures were once milked for their venom are also conducting trials for any
likely effects against diseases of the
Collecting mud samples from demand for these little animals central nervous system, such as
the deep sea or removing a few has soared. Research laboratories epilepsy. “We’re finding things that
sponges from a reef has minimal around the world became
environmental impact, but desperate to get their hands on are looking very promising,” he says.
bio-prospecting can sometimes cone snail venom ducts, the fleshy
lead to problems in the tubes that secrete conotoxins, and A new way to grow bugs
natural world. for a time the only place to find In the chase to find novel microbial
For centuries, tropical cone them was the wild. molecules, researchers face a major
snails have been renowned as Precisely how many cone snails
stumbling block – even though the
some of the deadliest animals were taken from coral reefs
in the sea, capable of killing worldwide isn’t known, but the natural world is teeming with
people by impaling them with number was undoubtedly microbes, only around one per cent
tiny, toxin-laden teeth. In the enormous. Laboratories reported will actually grow in laboratory
1980s, researchers traced the buying venom ducts by the pound, conditions. And if you can’t grow it in
snails’ deadly power to potent each consignment taken from at the lab, it becomes very difficult to
molecules in their spit, now least 10,000 snails.
known as conotoxins. Fortunately for cone snails study it. The standard approach is to
Further research revealed that alternatives were found. First, take samples of soil, deep sea mud or
each cone snail species makes cone snails were kept alive in blended sea sponge, separate out the
hundreds of different conotoxins, laboratories and milked for their bacteria and culture them on Petri
each having a highly specific venom, originally by persuading dishes. Roughly one in a hundred
effect on nerve cells, blocking or them to attack inflated condoms.
bacterial strains will survive in the
jamming open signals between More recently, molecular advances
them. This makes conotoxins mean that synthetic conotoxins lab, the rest perish outside their
immensely useful tools for medical can now easily be made, and wild natural environment. Until, that is, a
and neurological research, and as cone snail venom is no longer the new device came along that is helping
powerful drugs. Consequently, hot commodity it once was. to remove this hurdle by convincing
bacteria they’re still in the wild.
The Isolation Chip, or iChip, is a
small, plastic block pitted with
hundreds of tiny wells. To set one up
all you need to do is take a spoonful
of soil or mud, dilute it with water,
FLPA
and pour the mixture into the iChip.
Teixobactin is just one

of many thousands of
bacterial compounds
showing huge
Cone snails are venomous,
potential for the
predatory marine gastropods
that capture their prey using future of antibiotics
long, harpoon-like teeth

Next, cover the wells with a porous
membrane that allows nutrients and
water to pass through, but not
bacteria. Then bury the whole thing
in a bucket of the same sediment and
leave it for a month or so (and to
mimic the deep sea, put it in a
pressurised chamber). A single
bacterium sits in each tiny well and
soon begins to multiply. This gives
researchers hundreds of colonies of
individual bacterial strains ready for
testing, including many that
normally refuse to grow in the lab.
The whole thing seems remarkably
simple, but it took a research team at ISOLATION CHIP This small, plastic block contains hundreds of tiny wells in which
bacteria multiply to create hundreds of colonies that scientists can study
Northeastern University in Boston,
Massachusetts, more than a decade to
perfect. The team’s work, led by the development of drug-resistance. the natural world to see what else they
SLAVA EPSTEIN, NORTHEASTERN UNIVERSITY / SCIENCE PICTURE LIBRARY
Professors Slava Epstein and Kim This new antibiotic works by can find.
Lewis, hit the news headlines in 2015 attacking bacterial cell walls in a way It’s not yet a hundred years since
when they announced their discovery never seen before, and which bacteria Alexander Fleming made the
of a brand new antibiotic. may find very difficult to overcome. revolutionary discovery that a patch
Teixobactin is made by a strain of Within the confines of the lab, the of mould could kill bacteria. Since
bacteria found in a soil sample from a Northeastern researchers did all they then, many more antibiotics have
field in Maine. It’s just one of many could to encourage bacteria to been found, and many of them used
thousands of bacterial compounds develop resistance to teixobactin, but and overused until they no longer
newly isolated in iChips, and it’s they failed. work against virulent, resistant strains
showing huge potential for the future “At this stage there appears to be of bacteria. The search for new, more
of antibiotics. Anthrax, tuberculosis no route to resistance,” says Dr. Race, effective medicines has never been
and the notorious superbug MRSA of the new finding. more urgent. And even though there
have all succumbed to teixobactin in Time will tell whether teixobactin are now technologies and powerful
lab tests. makes it to market. In the meantime, research tools that Fleming would
Even more promising is the Epstein, Lewis and colleagues will never have dreamt of, researchers are
discovery that it could help combat continue dipping their iChips into still returning to the natural world
for inspiration.
Back on the reef, my dive
computer tells me that my collecting
An illustration of the
ground-breaking new
time is up. I slowly swim to the
antibiotic teixobactin surface and pass into the boat my
(yellow) causing a plastic sample bags, filled with blobs
bacterium to rupture
of shapeless goo. On deck, we empty
the bags into plastic trays and
meticulously label and document
each specimen. Then we parcel them
up, ready to freight to laboratories
where the task of hunting for useful
substances, and maybe even new
medicines, will begin. ■

NATURAL REMEDIES Q&A Special
QA &
SPECIAL
Expert advice on natural ways to stay
healthy, from avoiding jet lag to coping with
gluten intolerance, dealing with depression
to alleviating allergies...

Why do some people
get allergies?
Allergies are caused by an overactive immune
system. There’s evidence that this is inherited, but
many studies have also shown that growing up in an
excessively clean environment can trigger allergies.
People from big families tend to have been exposed
to more bacteria and have a lower chance of
developing allergies. But, for example, if you had
skin cream containing peanut oil as a baby, you are
more likely to be allergic to peanuts as an adult,
and soy in formula milk may also trigger peanut
allergies, perhaps because the proteins have similar
molecular shapes.
GETTY IMAGES

How long does a

bacterium live?
Bacteria don’t have a fixed lifespan
because they don’t grow old. When
bacteria reproduce, they split into two
equal halves, and neither can be
regarded as the parent or the child.
You could say that so long as a
single one of its descendants
survives, the original bacterium
does too. Individual bacteria can
also turn themselves into spores
with a tough coat to protect them
from dry conditions. Bacterial spores
have been successfully revived from
250-million-year-old salt crystals found
in New Mexico in 2000. But if we assume
that the global bacteria population is
stable, then it follows that one bacterium
must die for each new one that is produced.
Neisseria
Bacteria divide somewhere between once meningitides,
every 12 minutes and once every 24 hours. So the the agent which
average lifespan of a bacterium is around 12 hours or so. causes meningitis
What should I avoid if

I’m gluten intolerant?
Avoid anything with autoimmune condition,
wheat, rye, barley or where your immune
spelt. That means regular system becomes
bread, pasta, cereals, sensitised to gliaden, a
cakes and biscuits are protein in gluten.
out. You will also need to When you eat gluten
lay off the beer, and read your immune system will
labels carefully, as many not only attack these
processed foods have molecules, but also the
gluten in them. lining of your gut, causing
But be aware that inflammation, with
gluten-free foods are common symptoms
often packed with salt including bloating,
and sugar. diarrhoea, constipation
SCIENCE PICTURE LIBRARY / ALAMY
If you think you might and weight loss. The only

be intolerant to gluten, real way to test for
then you should get coeliac disease is to
yourself properly tested have a blood test,
to exclude coeliac where doctors look for
disease. Around one per antibodies. Alternatively,
cent of the population is have a biopsy of your
affected by this small intestine.

Top 10
common foods
highest in iron
RDA = recommended daily allowance
1. Liver
Iron in 100g: 23mg
264% men’s RDA;
155% women’s RDA
2. Dark chocolate
Iron in 100g: 17mg
195% men’s RDA;
114% women’s RDA
3. Pumpkin seeds
Iron in 100g: 15mg
172% men’s RDA;
101% women’s RDA
4. Oysters
Iron in 100g: 9.2mg
106% men’s RDA;
62% women’s RDA
5. Cashew nuts
Iron in 100g: 6.1mg
70% men’s RDA;
41% women’s RDA
6. Beef
Iron in 100g: 3.8mg
43% men’s RDA;
26% women’s RDA
Why do some people 7. Lentils

Iron in 100g: 3.7mg
get migraines? 42% men’s RDA;
25% women’s RDA
Amazingly, the precise cause of menopause. Certain foods and

migraines is still unknown. These additives can cause migraines, 8. Spinach
intense headaches, often on one and people who diet, skip meals Iron in 100g: 3.6mg
41% men’s RDA;
side and accompanied by nausea or consume a lot of caffeine can 24% women’s RDA
and sometimes visions of zigzag suffer. Disturbed sleep and jetlag
lines and extreme sensitivity to can also cause them.
SCIENCE PICTURE LIBRARY / ISTOCKPHOTO
light and noise, must be caused One rare inherited type called 9. Tofu
by abnormal brain activity. But familial hemiplegic migraine is Iron in 100g: 2.7mg
31% men’s RDA;
we just don’t know what kind or caused by four specific gene 18% women’s RDA
whether there are many mutations. More common types
different causes. are also associated with many
Hormonal fluctuations, different genes that affect brain 10. Quinoa
especially in oestrogen, can function. The simplest answer Iron in 100g: 1.5mg
17% men’s RDA;
trigger migraines. So some lies in the family. Up to 90 per 10% women’s RDA
women suffer more during cent of sufferers have a family
menstruation, pregnancy or history of migraines.
´

What’s worse for your mood — interrupted

sleep or shortened sleep?
Interrupted sleep. At least, that’s than usual, while others had be like being woken by a crying
what one recent study shows. their sleep interrupted several baby or a snoring partner. They
We’ve long known that sleep times. Both groups had the same break into your sleep cycle at
deprivation makes people bad- total amount of sleep, but the random times, therefore disrupting
tempered and miserable, and that interrupted sleepers reported the normal sleep pattern. But if you
insomnia is linked to depression, worse changes in mood. regularly wake up in the night, you
but exactly why is less certain. The researchers concluded that are probably waking at the end of
When volunteers slept in a lab and a lack of slow-wave sleep, which is each cycle, and so this would not
reported their mood every day, the deepest type of sleep, was to have the same detrimental effect
some were made to go to bed later blame. But these interruptions may on your slow-wave sleep.
ALAMY

What are the most
successful therapies
for depression?
There’s no simple answer long sessions. But a newer
because success depends therapy called behavioural
on age, sex, the type of activation also did well.
depression, and whether These are both based on
it’s combined with anxiety the idea that depression is
or other mental-health made worse by adopting
problems. Generally, the wrong coping
therapies based on strategies. So patients are
exploring and changing the helped to understand what
patient’s own thoughts and triggers their depression
behaviour are far more and how their reactions to
effective than traditional life’s events affect their
talking therapies, such as moods and emotions.
psychoanalysis. Alternative Learning to replace bad
therapies, although coping strategies, such as
popular, also fare badly. drugs and drink, with
One meta-analysis positive coping strategies
combined many studies can help, either used alone
and found that cognitive or in combination with
behavioural therapy (CBT) medication. See page 102
did best, especially with for a good herbal remedy.
What vitamin could you

live the longest without?
Vitamin E. Adults only need 15mg a day and you’d get
that from three tablespoons of sunflower or rapeseed
oil, as well as lots of other common foods. The only
people who normally suffer from vitamin E
deficiency are those with another disorder,
such as cystic fibrosis, that interferes with
its absorption. Vitamin E is an antioxidant
that protects your nerves and retinas
from damage caused by free radicals.
But even people born with a genetic
disorder that prevents them
from using vitamin E don’t
develop symptoms for at
least the first four
years. Although
the disorder can
cause blindness
ISTOCKPHOTO / GETTY IMAGES
and muscle
weakness, it isn’t
normally fatal.
Molecular model
of Vitamin E with
Vitamin E capsules
´

Six tricks to
help avoid jet lag
Travelling long-haul this
summer? These simple steps
can help you to beat the pain…
Choose the right trip
If you like staying up late, it
could be a sign your body
clock runs slower than
average. People like this
find it easier to fly west,
but much harder to fly east.
Prepare yourself
If you can, shift your sleep
patterns before you fly. If
you’re flying east, going to
bed and getting up a few
hours earlier the week
before will reduce the
difference when you arrive.
Use the flight

Give yourself more time to
adapt by changing your
watch as soon as you
board the plane. You’ll
have to eat and sleep
according to the time at
your destination as well.
Keep drinking
Dehydration doesn’t help,
so drink plenty of water
and stay off the coffee.
The air on a plane is
drier than on land, so
you’ll probably need to
drink more than you
Is mindfulness good for you?
usually would.
Generally, yes, but not always and groups and few have looked
Catch some rays not for everyone. Derived from seriously at negative effects. Being
Daylight helps you adjust, Buddhist teachings, mindfulness mindful is extremely hard at first
so go for a walk outside means paying steady attention to — trying to clear your mind means
when you arrive. If it’s the present moment without letting facing up to all those unwanted
night-time, avoid using your mind wander into fantasies, thoughts and fears. This can be
laptops and phones —
fears or planning (see page 109). painful and disturbing, so some
these give off light that
You can practise mindfulness in people feel a lot worse before
confuses your body.
meditation or in the midst of finding the benefits of a calmer
Time capsules
ordinary life. The Mindfulness- mind. Stress hormones can
Melatonin tablets are Based Stress Reduction increase even when people say
proven to help with trips programme claims to decrease they feel more relaxed, and
east if they’re taken at the anxiety and depression, and psychiatrists have warned of
right time, a few hours increase concentration and troubling side-effects, including a
wellbeing, with remarkable results changing sense of self, and floods
GETTY IMAGES
before bed. In the UK,

you’ll need a doctor to reported from prisons, schools, of traumatic memories. A good
check it’s okay for you. homes and workplaces. Yet many mindfulness teacher makes all
experiments lack proper control the difference.

Does locally
produced honey
prevent hay fever?
No. The myth is that local pollen in honey
can desensitise the allergic reaction, but
there’s no evidence to support it. A 2002
study at the University of Connecticut
compared locally-produced, unfiltered honey,
with nationally-produced, filtered honey and
honey-flavoured corn syrup. In double-blind trials,
there was no difference between the three in
reducing hay fever symptoms. The pollen in honey is
nearly all the heavy, flower pollen that doesn’t cause
hay fever. The pollen that sets your nose running is
much lighter and comes from grasses and trees that
bees don’t visit.
Do we still get
vitamin D from
sunshine when we
sit behind glass?
No. Ordinary window glass is only transparent
to wavelengths of light longer than 330
nanometres. But to synthesise vitamin D, we
need UVB wavelengths between 270 and
ALAMY / GETTY IMAGES
300nm. You can get a suntan through glass,

but to make vitamin D you need to be
outside. On the other hand, at least 50 per
cent of UVA can penetrate through glass, so
skin ageing can still take place. ■

ALTERNATIVE
THERAPIES
THE REAL SCIENCE BEHIND THESE REMEDIES
+ EASTERN PRACTICES
The health benefits of yoga and tai chi
+ ACUPUNCTURE UNRAVELLED
The truth behind this ancient practice
+ Sorting fact from fiction in
CHIROPRACTIC THERAPY
+ Revealed: ALTERNATIVE THERAPIES
which work (and the ones that don’t)
+ The impressive benefits of
MINDFULNESS MEDITATION
ISTOCKPHOTO

ALTERNATIVE THERAPIES Eastern Influence
GETTY IMAGES

EASTERN
Influence
Ancient practices, like yoga and tai chi, have been around
for centuries in the East. But following the cultural swing in
the ‘60s, they’re now also mainstream in the West.
ZOE CORMIER investigates their potential health benefits
´

C
hances are you pass
at least one yoga
studio on your way
to work. Where once
you laughed at the
slightly bizarre-
sounding term
‘downward dog’, it’s now likely to be
part of your everyday urban
dictionary. Indeed, yoga is booming.
And devotees claim that daily practise
not only helps them stay healthy – it
also keeps them sane.
“These are more than mere
health-care practices – they’re often
tied to an entire world view, and once
something becomes part of your
identity package, it becomes hard to
dispassionately address it,” says
Professor Timothy Caulfield,
Research Chair in Health Law and
Policy at the University of Alberta,
Canada, and author of The Cure for
Everything: Untangling the Twisted
Messages about Health, Fitness and
Happiness. “A massive industry has
built up around these practices –
there’s a huge amount of marketing
and advertising behind them.”
But does that mean there are no people find emotionally appealing.” reducing pain, improving memory,
benefits? Of course not, he says. But Nonetheless, a cursory browse treating arthritis, alleviating
the likes of yoga and other Eastern through scientific journals will depression, fine-tuning balance,
physical disciplines are on a par with uncover thousands of studies that treating insomnia, and helping with
the benefits from any other form of purport to show real, measurable dozens of chronic health conditions
light exercise or focused relaxation. biological benefits. from COPD to type 2 diabetes to the
“There’s nothing special or magical side effects of chemotherapy.
about tai chi or yoga. The muscles in The Red Dragon rises One of the biggest problems with
your body don’t know if you’re doing Take the case of tai chi. This Chinese all research that purports to show the
downward dog or bench presses. It’s martial art involves slow but precise benefits of complementary medicine,
just that there are underlying movements. Studies claim this gentle says Professor Michael Irwin, MD, of
philosophies to these disciplines that exercise has all sorts of benefits: the University of California, Los
Angeles Collaborative Centers for
Integrative Medicine, is that they
‘Yogis’ had more grey matter in a part of measure the influence of a treatment
– say, mindfulness – without
the brain called the ‘insular cortex’, which comparing it to the influence of a
GETTY IMAGES
‘gold standard’ well-recognised

correlated with increased pain tolerance treatment, such as a medication.
“Where is the comparative efficacy

mean that we should dismiss tai chi: what does the science say? Thousands
“There’s something more complex of studies have found numerous
going on.” benefits. Yoga seems to particularly
In this – and other studies – tai help alleviate depression caused by
chi selectively reduced inflammation, insomnia, as it regulates melatonin
as measured by blood levels of a levels in the blood, aiding sleep
protein called C-reactive protein, patterns. Some studies, however,
which is produced by the liver in have made more grandiose claims,
response to injury or some other form such as one in the California Journal
of physical stress. of Health Promotion from 2015
“But, while tai chi didn’t target stating that “yoga in jails helps make
sleep behaviour, it did target better fathers”.
overarching bodily processes, most Psychologist Dr. Catherine
importantly inflammation,” he says. Bushnell, Scientific Director of
“When you suffer inflammation you the Division of Intramural Research
report more depression, fatigue and at the National Center for
feelings of social disconnectedness. If Complementary and Integrative
you reduce inflammation, you Health in the US has investigated the
begin to feel better in a measurable, physical effects of yoga
number of ways.” by looking at the brains of people
So tai chi’s many devoted who practise it regularly. In 2014
practitioners can feel reassured. in the journal Cerebral Cortex,
she and her co-authors reported
Strike a pose that ‘yogis’ had an increased
GO WITH THE FLOW The Eastern practice that’s amount of grey matter in a part
A group practices tai probably been most widely adopted of the brain called the ‘insular
chi in Lumpini Park in
Bangkok, Thailand in the West is yoga. In any given cortex’, which correlated with
year, seven per cent of American increased pain tolerance. The
adults practise yoga at some point. more experience subjects had
data?” says Prof. Irwin. “As a medical Yoga dates back to the fifth with yoga, the more grey
doctor, I need to know if these century BCE in India. The matter in the insular cortex,
practices work as well as standard practice involves a routine of and the more pain tolerance.
treatments, because we’ll never get stretches and poses, combined Delving deeper into the
them into the public health sector with breathing exercises and brain, in 2015 the same team
unless we can show that they’re as bouts of meditation, and comes published a detailed report
efficacious as what’s already on offer.” in a huge variety of forms – in Frontiers in Neuroscience
Which is why Dr. Irwin decided from the athletic (such as comparing the brains of
to compare cognitive behavioural Ashtanga) to the more meditative people who regularly
therapy (CBT) with tai chi, which (like Yin) to Westernised versions practise yoga with
in the past he had found useful in (such as acroyoga). people who do not.
alleviating insomnia for the elderly. Millions anecdotally report a Magnetic resonance ´
In a study published in the journal huge range of benefits from
Sleep in 2014, they reported that increased strength and flexibility,
when treated with either CBT, tai chi pain relief and heightened energy,
or sleep seminar education, people to more esoteric psychological
given CBT fared far better than those effects, such as Seven per cent
ISTOCKPHOTO
with either sleep education or tai chi depression alleviation of American

adults practise
– it was almost twice as effective. and reduced yoga in any
But Prof. Irwin warns that doesn’t anxiety. But given year

WARRIOR II POSE
This yoga posture is
also known as
Virabhadrasana II
imaging showed measurable several different activities that are components of yoga. Both appear
differences in a number of brain healthy for you,” says Dr. Bushnell. to have a significant effect (see page
regions, which the team say could Moreover, yoga may just work 106), but how do they work in
explain why the grey matter of yogis particularly well because of the combination? As the effects are
declines more slowly than their routine and structure that is built difficult to tease out, scientists are
contemporaries. “Yoga seems to offer into the practice – just as the not quite sure yet.
a protective effect as we age,” says discipline required for chess or What is clear is that yoga can be
Dr. Bushnell. Impressive and detailed Sudoku may help with someone’s good for you. So should everybody
as the analysis is, could it just be as mental dexterity. take it up, as the Prime Minister of
Professor Caulfield suggests – the India has repeatedly proclaimed?
product of exercise, maybe with some Mind and matter Not necessarily.
relaxation thrown in? One interesting question to come out If you have limited mobility, due
GETTY IMAGES
“Prof. Caulfield is absolutely right of Bushnell’s neuroimaging work is to arthritis or some other health
– there’s nothing special about yoga. the relative contributions of the condition, attempting to perform
It’s just that the practice combines meditative and the physical complex positions can be painful,

There’s nothing special about yoga, the
practice just combines several different
activities that are healthy for you
Dr. Bushnell, US National Center for Complementary and Integrative Health
LOST IN THOUGHT
The relaxed Sukhasana
pose allows yoga
practioners to meditate
disorder. Her 2014 report in the Previous reports, such as in the

Journal of Psychiatric Practice showed Journal of Mental Health, Religion &
that the vast majority of respondents Culture in 2001, showed that even
felt yoga had a variety of positive sedentary medication can precipitate
effects on their general health, but mania and psychosis.
also cognitive benefits, like feelings of New, heated forms of yoga, such
emotional positivity, distraction from as Bikram, were even more likely to
worry and increased clarity. The cause these manic symptoms.
stressful and demoralising. And, for survey contained comments such as: Maybe not surprising, as there is
some people, stress can be a catalyst. “Yoga reminds me that there can be physiological evidence that heated
Dr. Lisa Uebelacker, Associate happy moments,” “It deters reclusive yoga can speed the body’s metabolism
Professor of Psychiatry and Human behaviour,” and “It gives me a break of medications, like aripiprazole.
Behavior at Brown University in from my thoughts.” So, it seems that yoga can be
Rhode Island, US, carried out a small Overall, 44 per cent of the beneficial for many, but potentially
study on people with bipolar disorder, respondents said that yoga reduced dangerous for some. Yet that is true
who suffer from dramatic highs and their manic or hypomanic symptoms, of every form of exercise and mental
lows, but do not tend to respond to 19 per cent said it sometimes did, and training. Everybody is different, and
medication for their bipolar disorder. seven per cent said yoga did not there is no such thing as a one-size
Dr. Uebelacker wanted to find out reduce their manic symptoms. fits-all solution. Which is exactly
whether yoga might help, so she But here’s where things get more what centuries of scientific scrutiny
GETTY IMAGES
conducted an internet survey of 70 complicated: when asked if yoga ever of the human condition has shown
yoga practitioners who met all the had a negative impact on their bipolar – diversity is the norm, and
formal diagnostic criteria for bipolar symptoms, nine per cent said yes. exception is the rule. ■

ALTERNATIVE THERAPIES Acupuncture Unravelled
Acupuncture
UnravelledMillions of people around the world use acupuncture for a
whole range of conditions. But does science support the
practice? Is it really worth turning your body into a pin
cushion? EDZARD ERNST investigates
ISTOCKPHOTO

ANCIENT PRACTICE
Acupuncture involves
piercing the surface of the
skin with fine needles

O
f all the alternative picture does not become much totality of the available evidence, and
therapies, clearer: for every trial suggesting that this is best done by conducting what
acupuncture is acupuncture works for this or that is called a ‘systematic review’.
perhaps the best condition, there is at least one further Most experts agree that, among
known. Almost study showing the exact opposite. systematic reviews, so-called
everyone seems to Cochrane Reviews are second to none
have heard that it is In search of evidence – they are regularly updated to the
ancient, comes from China and In such a situation it is tempting to highest standards by independent
involves sticking needles into special select those results that seem to experts in a transparent fashion.
points along lines called ‘meridians’. confirm our preconceived ideas and Today, numerous Cochrane Reviews
But does it work? The answer to this discretely forget about the rest. are available, summarising the
question depends on who you ask. However, cherry-picking is a evidence for acupuncture as a
Sure it works, say the sceptics – it’s hallmark of pseudoscience of which treatment of specific conditions (see
a powerful placebo (see right), but it acupuncture, like all alternative ‘What the science says’ on page 90).
has no effects beyond that. By medicine, has more than its fair share. What’s evident from these
contrast, some physicians claim that If we are interested in the truth, we publications is fairly obvious –
it is helpful for a limited range of must always critically evaluate the acupuncture has been studied for a ´
conditions, yet admit that the effect is
far from impressive. And an
acupuncturist might explain that his
therapy would not have survived
thousands of years, if it were not
effective – it re-balances the body’s
life-energy and therefore works for
any condition that afflicts humans.
Yes, the realm of acupuncture is
rife with opinions and fallacies – and
short on certainties. The popular
argument that any treatment which
has ‘stood the test of time’ must also
be good, for instance, is a classic
fallacy that regularly misleads many
of us. If we want to know the truth,
we better look for some real evidence
– and, in medicine, that means results
of clinical trials.
Thousands of such studies are
currently available. At first sight, this
seems like good news, but oddly it is
GETTY IMAGES
ANCIENT ART
yet another source of confusion – An old Chinese traditional
medicine book that dates
the vast majority of these trials are of from the Qing Dynasty
such poor quality that they tell us
next to nothing. Moreover, several
investigations have demonstrated that
virtually all studies originating from
If we want to know the truth, we better look
China arrive at positive conclusions for some real evidence – and, in medicine,
– their reliability is thus less than
encouraging. Even if we only assess that means results of clinical trials
the seemingly rigorous studies, the

ALL IN THE MIND
Taking an inert substance,
such as a sugar pill, tricks
the brain into thinking
it’s beneficial
The Placebo Effect

How the body reacts when unknowingly given an inert treatment
The mind is a powerful tool. It plays effects of a compassionate and thus benefit patients. So,
a crucial role in the placebo effect consultation with a healthcare clinicians often try to maximise
– the beneficial physical effect professional, and the fact that them. As all therapeutic
experienced by a person when they humans change when being interventions are associated
undergo an inert treatment. For observed (the Hawthorne Effect). with placebo effects, they don’t
example, if someone takes a pill Placebo effects are non-specific necessarily need to administer
that they think will help alleviate effects, and are the result of placebos for that to happen.
pain, but it’s just an inert sugar pill unconscious conditioning and If a patient’s symptoms are
containing no active substance, conscious expectation. Neuro- improved after the administration
yet they start to feel better, the imaging, and other studies, have of a therapy, one tends to assume
placebo effect has been at work. found that people experience the that this is the result of the
Every time a person is treated, placebo response due to a release treatment. However, because
they experience two main effects: of certain neurotransmitters. the therapeutic response is
the specific effect of the treatment, Non-specific effects can distort normally not just the result of
and a range of non-specific effects. the results of clinical trials, and the therapy, but also due to a
The latter are largely unrelated to therefore investigators try to multitude of phenomena, this is
the actual treatment – like the minimise them in research. In not necessarily true. Patients
GETTY IMAGES
fact that most conditions get clinical practice, placebo effects improve even with ineffective or
better even without treatment, the can positively impact the outcome, mildly harmful treatments.

What the
science says wide range of conditions, and
critical assessments of the findings
therapies that are effective beyond
placebo. According to the best
rarely, if ever, generate a convincingly evidence available, acupuncture does
Conclusions from the 10 positive verdict. not fall into this category.
most recent Cochrane The slightly paradoxical thing is,
Reviews on acupuncture How could it work? we do not need placebo therapies for
Given that we cannot be sure whether generating placebo effects – giving
“Acupuncture could be a valuable acupuncture works, it seems almost effective treatments with compassion
non-pharmacological tool...” futile to ask “how does it work?” Yet and empathy also generates placebo
[tension-type headache]. it is only fair to mention that several effects, which is an almost inevitable
“Acupuncture without electrical theories as to acupuncture’s mode of bonus to any intervention. In other
stimulation probably does not action have been formulated. words, the placebo effect is no
reduce pain or improve fatigue, Traditional acupuncturists tend to justification for employing these
overall well-being or sleep” adhere to the old Chinese myth that treatments – otherwise we open the
[fibromyalgia]. acupuncture works by re-balancing door to all sorts of quackery to the
“The current evidence is not our life-forces when they have detriment of effective healthcare.
sufficiently rigorous...” [insomnia]. become unbalanced. Western
acupuncturists, by contrast, are keen The trump card
“Acupuncture may reduce on suggestions that acupuncture Time to play the last trump card in
period pain.”
affects neurophysiological pathways, the hands of acupuncture fans –
“We found insufficient evidence for instance, by increasing the level of safety. At least, our treatment cannot
to recommend the use of endorphins in the brain. Sceptics cause any harm, they claim. Yet
acupuncture for people would, however, insist that these again, sceptics are not impressed by
with depression.” notions are mere theories. The this argument and stress that this
“We found insufficient evidence explanation for both the evidence statement is based more on wishful
to determine whether from clinical trials and the millennia thinking than on sound evidence.
acupuncture is effective for of experience is much simpler – Even Chinese acupuncturists recently
controlling menopausal acupuncture has all the qualities of a agreed with this view. They
vasomotor symptoms.” powerful placebo, as it’s exotic, summarised all the adverse events of
“The current evidence does invasive, mildly painful and involves acupuncture ever published in the
not support acupuncture for touch and time with a therapist. Chinese literature, and found 1,038
treating epilepsy.” But surely the main thing is not cases of serious adverse events,
the mechanism of action, but the fact including 35 fatalities and hundreds
“Sham-controlled RCTs have that acupuncture helps patients, even of potentially life-threatening
found no benefits of acupuncture
relative to a credible sham if the benefit heavily relies on placebo complications. To put this into
acupuncture control for IBS and other non-specific effects. In this context, in general, Chinese
symptom severity or IBS-related case, do we really need acupuncture? publications are strongly biased in
quality of life.” We could simply maximise the favour of acupuncture, as shown by
placebo effect the best we can, while an article in Controlled Clinical Trials.
“We could not reach any
conclusion about the efficacy and simultaneously administering Thus the level of under-reporting
safety of acupuncture as we treatments that truly work, such as must be assumed to be huge, and the ´
identified no trials for inclusion in
this review” [mumps in children].
[The evidence] “does not provide Acupunture has all the qualities of a powerful
reliable support for either the
effectiveness or safety of placebo, as it’s exotic, invasive, mildly painful
acupuncture” [sudden onset
ankle sprains in adults]. and involves touch and time with a therapist

KNEE-DEEP IN NEEDLES
An acupuncturist treats a
patient’s knee by inserting
fine needles into the joint
GETTY IMAGES

LIFE FORCE
Acupuncturists stick
needles into special
points along lines
called ‘meridians’
GETTY IMAGES

According to the more modern view of
acupuncture, it might be effective for just
true figure of adverse effects caused
by acupuncture could be much a very small range of conditions
bigger. From large studies done in the
West, we know that about 10 per cent
of all patients will experience mild to
moderate adverse effects after on giving it a shot, it’s worth bearing a life forces, and could be said to use
acupuncture. The most frequent type few things in mind. It is often non-scientific diagnostic methods.
of serious complication is caused by claimed that acupuncture has ‘stood In contrast, medical acupuncturists
an acupuncture needle piercing an the test of time’, and that its long tend to cite neurophysiological
internal organ, such as a lung or the history proves its effectiveness and explanations as to how acupuncture
heart. If we add to all this the risks of safety. This argument is as popular in might work. These may appear
false diagnoses through the obsolete the realm of alternative medicine as it scientific and plausible, however, they
techniques used by traditional is misleading. A long history of usage are just theories and constitute no
acupuncturists, it’s impossible to deny proves very little – think of blood- proof for the validity of acupuncture
that acupuncture has considerable letting which was used for millennia, as a medical intervention. And then
potential to do serious harm. even though it killed thousands. there are the therapeutic claims
Secondly, we often think of made for acupuncture, which are
A fine line acupuncture as being one single mostly unfounded.
Considering the complexities, treatment, but there are numerous According to the traditional view,
myths, fallacies, uncertainties and different forms of this therapy and acupuncture is useful for virtually
confusions around the topic, it is many types of therapists. Traditional every condition affecting mankind.
not easy to come up with any clear Chinese acupuncturists have not But according to the more modern
recommendations for those who normally studied medicine. They view, it might be effective for just a
are nevertheless tempted to try base their practice on the Taoist very small range of conditions. Once
acupuncture. So if you’re planning philosophy of the balance between we critically examine the reliable
evidence, we realise that acupuncture
relies heavily on a powerful placebo
effect. The question of whether it has
effects beyond placebo has so far not
been answered conclusively.
Few acupuncturists seem to warn
their patients of possible adverse
effects. Yet minor side effects occur
in about 10 per cent of all patients,
and numerous serious complications
are on record. Well over 100 fatalities
have been reported in the medical
literature – a figure which, due to
the lack of a monitoring system,
may represent the tip of a much
bigger iceberg.
Given that there is little good
evidence that acupuncture works
beyond a placebo response, and that
acupuncture is associated with finite
MERIDIAN LINES risks, it seems to follow that, in most
GETTY IMAGES
According to acupuncturists,
life force, known as ‘qi’, flows situations, the risk and benefit
through the body along these balance for this treatment fails to be
intersecting pathways
convincingly positive. ■

ALTERNATIVE THERAPIES Chiropractic Therapy
TO
CRACK
or not to
CRACK
Chiropractic therapy is used to treat all sorts of conditions.

But controversy reigns over how effective it actually is.
ALAMY
NATALIE ADAM investigates

SCIENCE PICTURE LIBRARY

M
any of us get a bad interference with the flow of what
back from time to they called innate intelligence (II)
time. In fact, it’s – an energy or force within the body.
the most common Some chiropractors claim that this
complaint among undetectable force is responsible for
people who seek all health complaints.
medical help. So But there’s no scientific evidence
where do these people go? According to support the existence of such
to research, a large number of subluxations or innate intelligence. In
Americans with back pain seek conventional medicine, the term
treatment from a chiropractor. subluxation is used to describe a
Chiropractors apply pressure to the partial dislocation of a joint, where
spine, usually with enough force to the bones meeting at that joint are
produce the characteristic cracking or moved away from their normal
clicking sounds people associate with position by trauma, such as the
the practice. It’s thought to come impact from a fall. These show up in
from the (painless) creation and x-rays, but would not normally be
popping of bubbles in the fluid that treated by manipulating the joint.
lubricates our joints. Some patients “The chiropractic term
fear the sound. Others relish it as subluxation is different and, although
the audible relief of stiff, tight, or some chiropractors claim to be able to
sore muscles. see them in x-rays, there seems to be
Chiropractic therapy has been no clear consensus as to what they
around for over 100 years. Daniel look like, with different practitioners
David Palmer came up with the often seeing greatly varied
concept in the late 19th century, after subluxations in the same spinal x-ray,”
he met janitor Harvey Lillard who says former psychiatrist Stephen
had suffered from impaired hearing Barrett, who is now a science writer
for 17 years. Palmer claimed that he and co-curator of the website
restored Lillard’s hearing by moving Chirobase, which he runs with
a misaligned spinal bone, or vertebra, retired chiropractor Sam Homola.
back into its normal position. Shortly Opinions on what to treat differ
after this, he realigned another among chiropractors – and this
man’s vertebra, reputedly helping to affects the way they practise. do not. The former are often
alleviate his heart trouble. Palmer Broadly speaking, the chiropractic considered to work more in line with
and his co-believers maintained that community has split into two camps conventional medical beliefs and
‘subluxations’, which they described – those that limit their treatments to evidence-based practices. The latter
as slight misalignments in the conditions commonly associated with are more likely to be thought of as
vertebrae, were the cause of all the musculoskeletal system – the ‘alternative’ in their practise. So the
health-related problems. This was framework of bones and muscles that big question is – does chiropractic
due to the subluxations causing make up the body – and those that therapy work? The answer, of course,
depends on two things: who you ask,
and what you ask them.
Many reviews and studies have found In search of evidence
inconclusive evidence for the effectiveness In 2010, the General Chiropractic
Council – the body that regulates all
of spinal manipulation for low back pain chiropractors in the UK – funded a
review into the effectiveness of

A chiropractor
manipulating the
lumbar vertebrae
manual therapies in the UK, and Chiropractors increasingly offer February 2015, he published a study
concluded that spinal manipulation a ‘one stop shop’ says Associate in the journal Spine which concluded
and mobilisation has moderate to Professor Michael Schneider, from that hands-on manipulation dealt
mild benefits in adults suffering from the Department of Physical Therapy, with low back pain more effectively
some types of back and neck pain. School of Health and Rehabilitation in the short term than what he
But chiropractors are not the only Sciences at the University of deemed “usual medical care” –
people to offer spinal manipulation. Pittsburgh, in the US. “Primary care where physicians advise patients to
Primary care physicians, physical physicians would diagnose low back stay physically active and prescribe
therapists and osteopathic doctors do pain, and are likely to offer some over-the-counter medication.
it, too. So why do 40 per cent of form of medication to alleviate pain, But other reviews and studies have
North Americans choose to go or referral to another provider for found inconclusive evidence for the
straight to a chiropractor, compared non-pharmacological treatment. A effectiveness of spinal manipulation
to 34 per cent who would visit a chiropractor provides both the roles for low back pain, or suggested
primary care physician, and just one of diagnosis and treatment.” that there is no clear difference in
per cent who would go to a physical Schneider has worked as a patient benefit seen from spinal
therapist or occupational therapist? chiropractor for over 30 years. In manipulation, compared to other ´

Manipulations of the seven uppermost

vertebrae can result in an artery supplying
therapies including exercise, no
therapy, or the use of non-steroidal the brain to tear, causing a type of stroke
anti-inflammatory drugs (NSAIDs),
such as ibuprofen.
In 2007, the American Pain
Society (APS) and American College have more positive conclusions than only two to three days, we might
of Physicians jointly published those authored by independent accept them as a necessary step on
clinical practice guidelines on the academics, as there is a conflict the way to getting better,” says Prof.
diagnosis and treatment of low back of interest.” Ernst. “But much more worrying are
pain. These recommend “non- In 2006, Prof. Ernst carried out the reports of serious complication
pharmacologic therapy with a systematic review of spinal associated with neck manipulations.”
proven benefits”, including spinal manipulation, where he analysed While there are reports of
manipulation, for low back pain. But collective data from sixteen papers. dislocations and fractures, more
the guidelines do point out that this is The verdict – they failed to show that concerning are the cases of stroke.
a “weak recommendation”, and APS spinal manipulation is an effective Manipulations of the seven
spokesperson Steve Majewski said: treatment for any condition. uppermost vertebrae can result in an
“whether a recommendation is weak artery supplying the brain to tear,
or strong is based on the quality of The risks causing a type of stroke called a
the evidence reviewed”. Ineffective is acceptable, but vertebral artery dissection (VAD), as
Who carries out a study and how ineffective and risky would cause shown in studies such as one by
they do it affects this quality of concern – so what are the side effects? University of California neurologists.
evidence – a view held strongly by The most common side effect of This can lead to permanent disability,
Edzard Ernst, Emeritus Professor of spinal manipulation is short-term or even death. “Several hundred such
Complementary Medicine, the soreness in the muscles around the instances have been reported,” says
University of Exeter: “Some studies manipulated area. This is no different Prof. Ernst. “But as there is no
are prone to bias. A good literature to feeling a bit sore after a massage. effective monitoring system, their
review must include some critical But there are more serious risks. true number could be much higher.”
assessment of the quality of the “About half of all chiropractic But Schneider points out that
methods used. There is evidence that patients suffer from mild to moderate VAD stroke is rare, and says patients
studies authored by chiropractors side effects but, as they usually last need to consider the risk against
benefit when deciding upon a
treatment option for neck pain. “Risk
is a relative thing. While a stroke is a
very significant risk, it is a very low
incidence risk that needs to be
weighed against the benefits of the
manipulation. For low back pain, the
benefits seem to outweigh the risks,
but if a patient is being treated for a
misdiagnosed condition, or one that
has no proven benefit, then the risk
appears more significant.”
Healing by placebo effect

The debate about the merits of
chiropractic therapy gets murkier still
GETTY IMAGES
when we move beyond the spine.

Some chiropractors claim to treat
conditions such as asthma and infant

Proprioceptive Neuromuscular
Facilitation (PNF) stretching is
used to treat torticollis, when
the neck becomes ‘locked’
colic, which aren’t problems normally manipulations is rarely encouraging.” fear create biological changes in the
associated by conventional medicine But, despite the mainstream brain that amplify our symptoms.
with the musculoskeletal system. scepticism, huge numbers of Trials suggest receiving empathetic
“If the risks outweigh the benefits, Americans still visit chiropractors care, as well as having positive
the treatment cannot normally be every year. So what’s the benefit? It expectations for treatment helps to
recommended for routine care,” could simply be an increasing desire reverse this. Psychological influences
says Prof. Ernst. “In the case of to avoid pills and a placebo effect (see such as empathy, social interaction
chiropractic therapy, the evidence page 89), linked to the one-on-one and expectation create biological
suggesting that it is effective is limited attention of a caring practitioner. changes that ease pain. So it’s not an
to very few conditions, and even there “Pain is linked to fear,” says illusion, or a change in perception,
it is too weak to claim it is of proven Jo Marchant, a science writer and the pain is reduced through just the
effectiveness. It follows that the risk/ author of Cure: A Journey into the same physical mechanism as when
benefit balance of chiropractic Science of Mind over Body. “Stress and you take a painkiller.” ■

ALTERNATIVE THERAPIES The Good, the Bad, and the Ugly
ALAMY

Alternative
THERAPIES
The Good, the Bad
and the Ugly
From homeopathy to hypnotherapy, EDZARD ERNST
looks at some well-known alternative therapies and
medicines – revealing which can work and which to avoid
A
lternative therapies is the conventional treatment available risk-free. This is dangerously wrong,
the umbrella term for a specific condition. because nature is not necessarily
for a diverse array of Why then are they so popular? harmless, and seemingly innocent
treatments, which One reason is that – rightly or treatments, such as homeopathy, can
have little in wrongly – conventional clinicians are become potentially life threatening.
common, other than often unable to build therapeutic For example, if a cancer patient
not being accepted relationships with their patients that forfeits conventional treatments
by most conventional healthcare are as empathetic and compassionate in favour of some homeopathic
professionals. So any general as those of alternative practitioners. In remedies, their life is in grave danger.
judgements about their effectiveness other words, the current popularity of So, the take-home message is to
are somewhat nonsensical. Very few alternative medicine is also a poignant be cautious, and study the evidence
GETTY IMAGES
alternative therapies are supported by criticism of modern health care. carefully and critically. If an
sound evidence and, to the best of our Most of us think that alternative alternative therapy sounds too good
knowledge, none works better than treatments are natural, and hence to be true, it probably is! ´

THE GOOD
Alternative treatments with encouraging evidence that they work
Herbal medicines clearly fall into this range of active compounds in the
category. They usually contain a extract turns out to be far less
multitude of pharmacologically active effective than the full plant extract
ingredients, so it’s hardly surprising with its multitude of ingredients.
that some of them are effective. Hypnotherapy is being promoted
Perhaps the best researched herbal for many conditions including pain,
medicine is St. John’s Wort, which is anxiety and smoking, but for none is
used mostly for mild to moderate the evidence stronger than for
depression. The most recent irritable bowel syndrome (IBS). A
systematic review showed that recent review summarised the
St. John’s Wort extracts were findings from 25 clinical trials, and
“superior to placebo” in treating concluded that “collectively this body
depression, as effective as of research shows unequivocally that
conventional anti-depressants for both adults and children with
and “associated with significantly IBS, hypnosis treatment is highly
fewer dropouts because of adverse efficacious in reducing bowel
effects”. (Having said that, St. John’s symptoms, and can offer lasting and
Wort interacts with around half of substantial symptom relief for a large
prescription drugs, so should be proportion of patients who do not
taken with care – see page 105.) respond adequately to usual medical
If herbal extracts can be that treatment approaches”. This might be
good, why not isolate the active on the optimistic side, but it is
principle from the messy concoction nevertheless clear, that hypnotherapy
of ingredients and market them as shows some promise.
pure compounds? This is precisely Some experts might object
what many scientists try to do, because they would not categorise
sometimes with huge success. hypnotherapy as an alternative
Aspirin, for instance, has been treatment. They might have a point:
derived from the willow bark and has one of the most notorious problems
become one of the most successful with alternative therapies in general
drugs of all time. But for other is that, once a therapy has been
herbs, such as St. John’s Wort, this shown to work, it will be accepted by
approach is not viable, because one health care professionals, and thus
single ingredient from the whole ceases to be ‘alternative’.
St. John’s Wort extracts

were “superior to placebo”
in treating depression
GETTY IMAGES

HERBAL BEAUTY
Hypericum perforatum,
commonly known as
St. John’s Wort

THE BAD
Treatments that have been shown to be ineffective
Few treatments ﬁt better into this than pure placebos (see page 89). methods. Healers claim to channel
category than homeopathy. It was Science is normally a poor tool for healing ‘energy’ into a patient’s
invented about 200 years ago by proving a negative, but in the case body, where it allegedly stimulates
the German doctor Samuel of homeopathy the evidence is now their self-healing mechanisms.
Hahnemann, who thought that fairly clear (it is only homeopaths There have been numerous studies
‘like cures like’. Essentially, this who refuse to accept it). The of these treatments, and the most
means that, if your eyes start most thorough assessment of rigorous of them seem to agree
watering when you cut an onion, homeopathy has recently been that the effects are due to placebo.
a homeopath would use the onion published by the National Health A recent study was aimed at
to cure conditions which are and Medical Research Council of testing the effectiveness of energy
associated with runny eyes. But Australia. The conclusions of this healing on the wellbeing of 247
homeopaths don’t just administer austere panel could hardly be more colorectal cancer patients.
the onion, they dilute the extract straightforward: “…there are no Compared with other patients
many times until typically not a health conditions for which there is who had not been exposed to the
single molecule of it is left in the reliable evidence that homeopathy healing ‘energy’, no overall effect
remedy they prescribe. is effective. Homeopathy should of healing was noted on quality of
Of course, such features render not be used to treat health life, depressive symptoms, mood
homeopathy utterly implausible. conditions that are chronic, serious or sleep quality. The authors
So, it is hardly surprising that the or could become serious.” concluded that the healing
300-odd clinical trials, which have Meanwhile, spiritual healing is the effectiveness on wellbeing was,
tested its effectiveness for various term often used for treatments however, related to factors such as
conditions, fail to show that such as Reiki, Therapeutic Touch, self-selection and a positive
homeopathic remedies are more and other para-normal healing attitude toward the treatment.
POINTLESS PILLS
Vials containing pills for
homeopathic remedies
GETTY IMAGES

BUY WITH CAUTION
Ingredients for sale at a
Traditional Chinese
Medicine store
THE UGLY
Potentially harmful treatments that should be avoided
Asian herbal remedies are shown to contain toxic substances protects a patient from a
notorious for being adulterated – causing damage to the liver, potentially deadly blood clot, or
with synthetic drugs, and some kidneys or other organs. Other that a woman gets pregnant
investigations have shown that herbal medicines have the potential despite taking oral contraceptives.
more than a quarter of Chinese to interact with prescribed And then there is the risk of
herbal creams contained potentially medicines. For instance, St John’s contamination or adulteration.
damaging corticosteroids. Wort interacts with about 50 per Recently the UK regulator recalled
While many herbal medicines, cent of all prescription drugs, a large quantity of St. John’s Wort
such as St. John’s Wort (see page and so the blood level of the tablets because they were
102), contain pharmacologically prescription drug can become contaminated with a liver-toxic
GETTY IMAGES
active ingredients, some herbal too low to have the desired effect. compound originating from another
medicines can also do harm. There In turn, this can mean that a plant that inadvertently made its
are many plants that have been prescribed anticoagulant no longer way into the remedy. ■

ALTERNATIVE THERAPIES Mindfulness
All in the
MIND
Far from just a hippie habit, mindfulness meditation is gaining
a following all around the world – becoming more and more
mainstream. ROBERT MATTHEWS looks at the science
behind it, and reveals how the practice is not only changing
the way we think, but our actual brain structure too
GETTY IMAGES

´

A
fter years of battling
chronic pain, Anne*
had all but given up
hope of finding a
safe but effective
source of relief. So
when a friend
asked her to try a radically different
way of dealing with her affliction,
she agreed.
As it involved sitting and actually
focusing on her pain, she could have
been excused for having her doubts.
Yet after trying it for eight weeks,
Anne was so impressed by the results
she decided to make it part of her life:
“I use it all the time, and it helps me
with my pain.”
She’s far from alone. Millions of
people are now using mindfulness
meditation to deal with a host of
conditions, from stress and depression
to physical pain and binge eating.
Based on ancient practices once
deemed the preserve of religious ALL IN A DAY’S WORK
Mindfulness meditation is
ascetics and hippies, the claims now now being practised by
being made for mindfulness Google employees at the
Googleplex headquarters
meditation are impressive – so much
so that multinationals like Google
PETER DASILVA/THE NEW YORK TIMES/REDUX/EYEVINE

and Ikea have embraced it. Last year millions of practitioners insisted it Institute of Technology in the US,
an All-party UK Parliamentary worked for them, its association with he began practising Zen Buddhist
Group called for its adoption by mysticism and navel-gazing led most meditation in the 1970s. His
schools, hospitals and prisons. scientists to avoid investigating it. Yet experiences led him to try distilling
Meanwhile, there’s been an explosion without proper scientific evaluation, its essence into a non-religious form
in the numbers of courses, books and what could be a genuinely effective he thought might benefit others.
websites offering to bring the power technique might never reach those Known as Mindfulness-Based
of mindfulness to us all. And of who could benefit from it. Stress Reduction (MBSR), it was
course, there’s no shortage of apps The scientist generally credited based around the practise of simply
for it. with breaking the deadlock is Jon observing one’s own mind at work,
Kabat-Zinn. As a molecular biology and noting what thoughts arise from
Science or self-deception? PhD student at the Massachusetts moment to moment without ´
Yet can so simple a technique really
achieve so much? Or do the claims
really say more about the power of
self-deception – and what are the
The claims now being made for mindfulness
risks of taking them seriously? meditation are impressive, so much so that
Until recently, evidence for the
effectiveness of the technique was multinationals like Google have embraced it
almost entirely anecdotal. While

In a nutshell
What mindfulness meditation is – and what it isn’t
The very idea of meditation find that within seconds their minds minutes or more. However it’s done,
comes with a lot of baggage and have wandered. The intrusive practitioners typically become
misconceptions. Some believe it thoughts can be anything from increasingly aware of the vagaries
demands religious faith. Others memories of past arguments to of the mind, and how acceptance of
think it requires hours of sitting in feelings of cosmic bliss. But, the even ‘bad’ thoughts helps rob them
the lotus position while banishing key to mindfulness is simply to note of their power.
all thought. that the thought has arisen and But as interest in mindfulness
In reality, mindfulness meditation return to focusing on the breath. meditation has grown, so have
simply involves becoming aware of The classic beginner’s mistake is reports of people having negative
one’s thoughts, feelings and to feel bad about having intrusive reactions to it. Some find
surroundings without judgement. thoughts or become lost in them. themselves experiencing traumatic
It can be done anywhere, “The brain will always produce thoughts, panic or even loss of the
anytime, though beginners are thoughts – that’s what it does,” sense of self.
advised to start practising in a says Harvard psychologist and According to Dr. Germer, such
place where they can sit quietly for mindfulness expert Dr. Chris responses can be a sign of being
a few minutes without distraction. Germer, author of The Mindful Path too hard on oneself: “Most adverse
The idea is then to become to Self-Compassion. “Mindfulness effects are caused by too much
aware – ‘mindful’ – of some allows us to develop a more formal sitting meditation practise.”
aspect of the present, such as one’s harmonious relationship with our He advises being less demanding
own breathing, and focus one’s thoughts and feelings.” – adding that one is still practising
thoughts on that. Starting with short sessions of mindfulness when just noticing, say,
This may sound simple, but even five minutes, the duration of the the warmth of the water during a
experienced practitioners often sessions can be built up to 30 morning shower.
GETTY IMAGES

PAIN RELIEF
Mindfulness meditation
has been found to aid
patients suffering from
judgement (see page 109). Thus, chronic pain
regardless of whether the thoughts
seemed good or bad, the practitioner
simply noted their existence, and let
them go.
By the 1980s, Kabat-Zinn had
begun reporting the outcome of his
studies of MBSR in serious scientific
journals. These suggested that the
technique could be effective for more
than just stress and anxiety. Patients
suffering from chronic pain that
had defied conventional treatment
reported feeling significantly
better after a 10-week course in
mindfulness methods.
In what has since become a
familiar feature of studies on
mindfulness, patients did not report
having rid themselves of all pain.
Instead, they talked of having
changed their response to it. Using
the mindfulness methods, they had
learned simply to note the existence
of the pain rather than judge it as bad
– and, in the process, found they had
robbed it of much of its power. sensation of eating – starting with the remained limited. Many of the claims
mindful consumption of raisins. were based on observations of small
Real-world benefits Kristeller and her colleagues found groups of patients. Few were based on
Other researchers began reporting that over time, the technique so-called ‘randomised controlled
similar benefits in an ever-growing allowed their patients to better trials’ (RCTs), in which patients are
list of ailments and conditions, from control their bingeing, and also randomly allocated either to receive
depression in pregnant women to became less depressed. mindfulness training, or a more
post-traumatic stress disorder in war Yet while the breadth of conventional treatment, or none
veterans. Mindfulness also seemed applications of mindfulness at all.
to help with behavioural problems, expanded, the depth of the evidence Regarded as the gold standard for
ranging from hostility among assessing the value of conventional
prisoners to attention deficits therapies, RCTs are time-consuming
of schoolchildren. and expensive to carry out. Yet
Mindfulness even appeared without them, claims for the
capable of reducing binge eating effectiveness of mindfulness
among people struggling with techniques risked
their weight. Impressed by remaining forever less
Kabat-Zinn’s findings, Jean than compelling. ´
Kristeller of Indiana State

University in the US developed
Mindfulness-Based Eating A new diet: people
struggling to control
Awareness Training (MB-EAT), their binge-eating are
which involves focusing on the finding mindfulness helps

Without randomised controlled
trials, claims for the effectiveness
of mindfulness risked remaining
forever less than compelling
GETTY IMAGES

Researchers are uncovering startling

evidence that the practice actually changes
Now the results of RCTs are
starting to emerge, with intriguing the physical structure of the brain
results. In 2011, a team led by Lone
Fjorback at Aarhus University
Hospital in Denmark, published a
systematic review of 11 RCTs of team have now been echoed by the mindfulness meditation works at
mindfulness-based treatments for latest state-of-the-art review more than just the level of conscious
mental health issues. According to published last year in Nature thought. Researchers are uncovering
the team, the treatments did appear Neuroscience. According to its startling evidence that the practice
to significantly improve mental authors, “Research over the past actually changes the physical
health and reduce the risk of falling two decades broadly supports the structure of the brain.
back into depression. claim that mindfulness meditation This astonishing phenomenon first
In 2013, the journal Clinical […] exerts beneficial effects on began to attract attention around a
Psychology Review published the result physical and mental health, and decade ago, following studies of
of an analysis of over 200 separate cognitive performance.” Buddhist monks carried out by
studies, in an attempt to give a broad But the team also noted that all neuroscientist Richard Davidson at
view of effectiveness. According to this still left one huge question the University of Wisconsin, US.
lead author Dr. Bassam Khoury of unanswered: how does mindfulness The monks appeared to have
the University of Montreal in actually work? patterns of brain activity significantly
Canada, the results were again different to that of untrained
encouraging: “Mindfulness-based Re-wiring the brain students used as ‘controls’. And
therapies were found to be highly Regular practitioners often talk of while all of them had practised
effective in treating psychological acquiring better insight and control meditation in Tibetan monasteries
disorders – namely anxiety and of the seemingly random flow of for many years, the differences were
depression – and somewhat effective thoughts, feelings and emotions most marked with the most
in diminishing psychological through the mind. That, in turn, experienced meditators.
symptoms associated with physical or seems to reduce their significance This intriguing finding led other
medical conditions, like pain.” and impact. researchers to use more sophisticated
The conclusions of Dr. Khoury’s It’s becoming clear, however, that methods capable of detecting actual
physical changes in the brain. And
the findings suggest that specific
parts of the brain are indeed modified
by meditation.
According to the most
comprehensive review of the research
so far, published in Neuroscience and
Biobehavioral Reviews in 2014, one of
the most consistent findings is
modification of a region at the front
of the brain called the rostrolateral
prefrontal cortex (RLPFC).
“While this region plays many
roles, it is particularly crucial for
meta-cognition and introspection,”
explains Kieran Fox of the University
SEEING THE LIGHT of British Columbia in the US, lead
GETTY IMAGES
Mindfulness-based therapies
have been found to be
author of the study.
effective for treating anxiety Another consistent finding was
and depression changes in the dorsal anterior ´

PREPPING FOR AN MRI SCAN Richard J. Davidson (centre), BRAIN SCAN Graphic renderings of Matthieu Ricard’s brain from a
director of the Waisman Lab for Brain Imaging and Behavior, functional Magnetic Resonance Imaging (fMRI) scan done at the
prepares Buddhist monk Matthieu Ricard (left) for an fMRI scan Waisman Lab at the University of Wisconsin-Madison
UNIVERSITY OF WISCONSIN-MADISON UNIVERSITY COMMUNICATIONS
WIRED UP Sitting in a sound-proof room, Buddhist monk Matthieu Ricard is wired up to an electroencephalogram (EEG). Small sensors
that are attached to the scalp pick up the electrical signals produced when brain cells send messages to one another

Cerebrum Somatosensory
cortex
Dorsolateral
prefrontal
cortex
Visual
cortex
Rostrolateral
prefrontal
cortex
Anterior
cingulate
cortex Insula Amygdala
Cerebellum
Hippocampus
MODIFIED BY MEDITATION
Mindfulness meditation
changes the rostrolateral
prefrontal cortex and dorsal
anterior cingulate cortex
cingulate cortex, or dACC. “This demonstrate that these structural validation of its claims as a side
finding is intriguing because the changes are related to changes in issue, given their own experiences
dACC is generally thought to be an cognitive ability or wellbeing, for – and that of countless others over
area critical to ‘self-regulation’ of instance, we shouldn’t assume that the centuries.
various kinds – for instance, these changes are necessarily good But for many others, like chronic
monitoring performance, making – or even meaningful.” pain sufferer Anne*, such validation
sure that behaviour remains adaptive Fox adds that the published studies helps combat doubts that so simple a
and flexible under changing may also be giving a biased picture of technique really can bring such
conditions, and controlling the truth. Researchers and journals impressive benefits.
impulses,” says Fox. “It’s easy to tend not to bother publishing boring, As Anne* puts it: “There is
see how a brain region with these negative results – and Fox and his something very powerful about
functions could be involved in – and colleagues found strong evidence of knowing there is physical objective
perhaps crucial to – meditation.” such ‘publication bias’. proof that it’s working.” ■
But he cautions against making Many practitioners of mindfulness
simplistic inferences. “Until we can meditation will see scientific *Some names have been altered.

ABOUT THE AUTHORS
THE SECRETS OF
NATURAL REMEDIES
Natalie Adam is a science Tom Ireland is managing
and medical writer and editor of The Biologist, the
editor, who has worked for Society of Biology magazine.
FROM THE MAKERS OF BBC FOCUS MAGAZINE The Institute of Cancer On page 34 he reveals why
Research, The Sanger Institute, bacteria are actually really
EDITORIAL London’s Science Museum good for us.
and for National Geographic
Managing Editor Daniel Bennett
documentaries. On page 94 she Rob Kemp is a freelance
Editor Jheni Osman
looks at chiropractic therapy. health and fitness journalist.
Art Editor Paul Jarrold
He writes for newspapers,
Series Art Editor Susanne Frank
Zoe Cormier is a science magazines and websites, such
Picture Editor James Cutmore
writer, author and broadcaster. as Men’s Health, Outdoor
Editorial Production Margaret Harris
Her books include Sex, Drugs Fitness, Runner’s World and
Additional work by Joe Eden, Jason Goodyer,
and Rock n’ Roll: The Science Cycling Plus. He is the author of
Alice Lipscombe-Southwell, James Lloyd, Samantha Nott
of Hedonism and the Hedonism several books including
www.sciencefocus.com of Science. She is the founder Parkrun: a celebration. On page
of the science outreach 40 he looks at how exercise
organisation Guerilla Science. helps with many maladies.
She reveals natural remedies
for pregnancy and birth on Robert Matthews is a
page 48, and on page 80 Visiting Professor of Science at
PRESS AND PUBLIC RELATIONS she looks at ancient Aston University, Birmingham,
Press officer Dominic Lobley 020 7150 5015 Eastern practices. and a renowned science writer
dominic.lobley@immediate.co.uk for the likes of BBC Focus and
SYNDICATION Nicola Davis writes about New Scientist. On page 106 he
science and technology for The delves into the benefits of
Head of licensing & syndication Tim Hudson
Guardian and The Observer, mindfulness meditation.
International Partners’ Manager Anna Brown
and was commissioning editor
PRODUCTION for Observer Tech Monthly. She Jamie Millar is a freelance
Production Director Sarah Powell has a MChem and DPhil in writer and a contributing editor
Production Co-ordinator Emily Mounter Organic Chemistry from the to Men’s Health magazine.
Reprographics Manager Tony Hunt University of Oxford. On page Formerly of GQ, as well as
26 she reveals how bacteria wellness he also writes about
PUBLISHING can affect your mood. the less scientific sphere of
Publisher Jemima Ransome men’s fashion. On page 10
Publishing Director Andy Healy Edzard Ernst is Emeritus he investigates the science
Managing Director Andy Marshall Professor at the University of behind superfoods.
CEO Tom Bureau Exeter, the recipient of the
Deputy Chairman Peter Phippen John Maddox Prize 2015, and Helen Scales is a marine
Chairman Stephen Alexander author of A Scientist in biologist, writer and
BBC WORLDWIDE Wonderland and co-author of broadcaster, based in
Director of Editorial Governance Nicholas Brett Trick or Treatment. On page Cambridge. Her latest book
Director of Consumer Products and Publishing Andrew Moultrie 86 he reveals the truth behind is Spirals in Time. On page 62
Head of UK Publishing Chris Kerwin acupuncture, and on page she dives into the oceans
Publisher Mandy Thwaites 100 he looks at other and explores the jungles to
Publishing Co-ordinator Eva Abramik, UK.Publishing@bbc.com alternative therapies. reveal how bioprospectors
www.bbcworldwide.com/uk--anz/ukpublishing.aspx are finding natural remedies
Alex Harris is an award- in the wild.
With thanks to Clive Irving and Peter Kreisky, winning journalist and
The Kreisky Media Consultancy, LLC commissioning editor for Men’s Luis Villazon is a science
Health magazine, who lives and writer, with a BSc in computing
© Immediate Media Company Bristol Limited, 2016 works in London, and therefore and an MSc in zoology from
knows a thing or two about the Oxford University. His works
Not for resale. All rights reserved. No part of The Secrets of Natural Remedies may be
reproduced in any form or by any means either wholly or in part without prior written
stresses of urban living. On include How Cows Reach
permission of the publisher. Not to be resold, lent, hired out or otherwise disposed of by page 54 he reveals the best 20 The Ground. On page 18 he
way of trade at more than the recommended retail price or in mutilated condition. ways to deal with stress. looks at herbal remedies.
To make a complaint about editorial content please visit immediate.co.uk or contact our
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Cover pictures: Getty Images, iStockphoto, SuperStock, Corbis

Back cover picture: iStockphoto
THE FOCUS COLLECTION
THE SECRETS OF
NATURAL REMEDIES
“Studies show that St. John’s Wort is

more effective at treating depression
than standard anti-depressants.”
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THE FOCUS COLLECTION FROM THE MAKERS OF BBC FOCUS MAGAZINE

SUBSCRIBE TO BBC FOCUS MAGAZINE TODAY PLEASE QUOTE FOBZ16

ORDER ONLINE AT OR CALL

FROM TH E M AKERS O F FOCUS M AGA ZI N E

4 The Secrets of Natural Remedies

The Secrets of Natural Remedies 5

GETTY IMAGES / ILLUSTRATION: ROBIN BOYDEN

+ The science of SUPERFOODS

8 The Secrets of Natural Remedies

10 The Secrets of Natural Remedies

The Secrets of Natural Remedies 11

12 The Secrets of Natural Remedies

inhibit growth of cancerous human

The Secrets of Natural Remedies 13

The problem is not that superfoods are a con

admits Professor David Nieman, often referred to beverage is important enough to

14 The Secrets of Natural Remedies

The Secrets of Natural Remedies 15

16 The Secrets of Natural Remedies

superfood packs high levels cardiovascular disease risk,

The Secrets of Natural Remedies 17

What the scores mean

왎 첸 첸 첸 첸 Placebo (see page 89)

18 The Secrets of Natural Remedies

The Secrets of Natural Remedies 19

The yellow fruit

it because it can also lower your It’s a myth that

20 The Secrets of Natural Remedies

Echinacea purpurea contains

vegetables is important for

The Secrets of Natural Remedies 21

The nectar from

nutritional deficiency in the world,

active ingredient in St. John’s Wort repair muscle damage following

22 The Secrets of Natural Remedies

nettle root is effective against male

The Secrets of Natural Remedies 23

GETTY IMAGES / ALAMY

24 The Secrets of Natural Remedies

American ginseng may

RATING 왎 왎 왎 첸 첸 RATING 왎 왎 왎 왎 왎 RATING 왎 왎 왎 첸 첸

The Secrets of Natural Remedies 25

26 The Secrets of Natural Remedies

The Secrets of Natural Remedies 27

Brain-derived neurotrophic factor (BDNF)

of anxiety, despite having increased

28 The Secrets of Natural Remedies

The Secrets of Natural Remedies 29

30 The Secrets of Natural Remedies

Intestinal bacteria help

The Secrets of Natural Remedies 31

32 The Secrets of Natural Remedies

take it if you had depression – that’s

Of mice and men

The Secrets of Natural Remedies 33

34 The Secrets of Natural Remedies

36 The Secrets of Natural Remedies

home. Samples from homes with pets

The Secrets of Natural Remedies 37