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    Polyethylene Glycol 6000

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    hemya7
    Polyethylene glycol 6000 (PEG-6000) is a polyether compound used in industrial manufacturing and medicine. PEG has a repeating structure of HO-CH2-(CH2-O-CH2-)n-CH2-OH and is used as an inactive ingredient in pharmaceuticals as a solvent, plasticizer, and tablet lubricant. PEGylation involves attaching PEGs to protein medications to improve solubility. PEG is also used as a bowel prep and laxative. PEG has low toxicity and systemic absorption less than 0.5%.

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    Polyethylene Glycol 6000

    Uploaded by

    hemya7
    233 views4 pages
    Polyethylene glycol 6000 (PEG-6000) is a polyether compound used in industrial manufacturing and medicine. PEG has a repeating structure of HO-CH2-(CH2-O-CH2-)n-CH2-OH and is used as an inactive ingredient in pharmaceuticals as a solvent, plasticizer, and tablet lubricant. PEGylation involves attaching PEGs to protein medications to improve solubility. PEG is also used as a bowel prep and laxative. PEG has low toxicity and systemic absorption less than 0.5%.

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    Polyethylene Glycol 6000

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    Polyethylene glycol 6000 (PEG-6000) is a polyether compound used in industrial manufacturing and medicine. PEG has a repeating structure of HO-CH2-(CH2-O-CH2-)n-CH2-OH and is used as an inactive ingredient in pharmaceuticals as a solvent, plasticizer, and tablet lubricant. PEGylation involves attaching PEGs to protein medications to improve solubility. PEG is also used as a bowel prep and laxative. PEG has low toxicity and systemic absorption less than 0.5%.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    233 views4 pages

    Polyethylene Glycol 6000

    Uploaded by

    hemya7
    Polyethylene glycol 6000 (PEG-6000) is a polyether compound used in industrial manufacturing and medicine. PEG has a repeating structure of HO-CH2-(CH2-O-CH2-)n-CH2-OH and is used as an inactive ingredient in pharmaceuticals as a solvent, plasticizer, and tablet lubricant. PEGylation involves attaching PEGs to protein medications to improve solubility. PEG is also used as a bowel prep and laxative. PEG has low toxicity and systemic absorption less than 0.5%.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    PEG is a polyether compound used in pharmaceuticals and industrial applications. It has low toxicity and is used as a solvent, plasticizer, and lubricant. PEGylation increases drug solubility.

    PEG is used as a solvent, plasticizer, surfactant, in ointments, suppositories, and to lubricate tablets and capsules. It is also used for bowel preps and as a laxative.

    PEG has a repeating chemical structure and is also known as polyethylene oxide. It has low melting and boiling points, is soluble in water, and has low toxicity with minimal systemic absorption.

    Polyethylene Glycol

    6000
    PEG-6000

    6.POLYETHYLENE GLYCOL 6000


    Polyethylene glycol 6000 (PEG) is a polyether compound with many applications from
    industrial manufacturing to medicine. The structure of PEG is (note the repeated element
    in parentheses):

    HO-CH2-(CH2-O-CH2-)n-CH2-OH

    PEG is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending


    on its molecular weight.

    Polyethylene glycol, referred to as PEG, is used as an inactive ingredient in the


    pharmaceutical industry as a solvent, plasticizer, surfactant, ointments and suppository
    base, and tablet and capsule lubricant. PEG has low toxicity with systemic absorption less
    than 0.5%.

    PEGylation occurs when PEGs are attached to various protein medications, allowing for
    greater solubility for certain drugs. Examples of PEG medications include PEG-
    interferon alpha (Pegintron) and PEG-filgrastim (Neulasta). PEG is also available as a
    bowel prep for colonoscopy procedures and as a laxative.

    PEG 400 indicates the average molecular weight of the specific PEG at 400. [2] PEG 3350
    is a laxative available over-the-counter by the name of Miralax. In this case, PEG is
    considered an "active" ingredient, even though systemic absorption is less than 0.5%.

    Structure

    Fig.8.Structure of PEG-6000

    Institute of pharmaceutical science & Research centre Bhagwant University Page 53


    PEG-6000

    1) Nonproprietary Names
    1. Carbowax, GoLYTELY 4. Halflytely,
    2. GlycoLax, Fortrans 5. Macrogol,
    3. TriLyte, Colyte 6. MiraLAX
    2) Boiling Pt: Min. 250°C (1013 hPa)
    3) Melting Pt: 55 to 62 °C
    4) Density: 1.13 g/cm³ (20°C)
    5) Appearance White or almost white, waxy or paraffin-like
    6) Solubility: Soluble in waterIN WATER Y IN WATER

    7) Synonyms

    PEG; Macrogol; Polyoxyethlene; Aquaffin; Nycoline alpha-hydro-omega-hydroxypoly(oxy-


    1,2-ethanediyl); polyethylene glycols; Poly Ethylene Oxide; Polyoxyethylene;
    Polyglycol; 1,2-ethanediol Ehoxylated; Polyoxyethylene ether;
    Polyoxyethylene; Poly(ethylene glycol);

    Chemical Name and CAS registry Number

    poly(oxyethylene, (25322-68-3 )

    Empirical Formula and Mol. Weight


    H(OCH2CH2)nOH [average 6000 g/mol ]

    Functional Category

    Lubricating agent , solubilizing agent, coating agent

    Applications in Pharmaceutical Formulation or Technology

    Chemical uses
    Polyethylene glycol has a low toxicity and is used in a variety of products.[16] The polymer is
    used as a lubricating coating for various surfaces in aqueous and non-aqueous environments.

    Since PEG is a flexible, water-soluble polymer, it can be used to create very high osmotic
    pressures (on the order of tens of atmospheres). It also is unlikely to have specific

    Institute of pharmaceutical science & Research centre Bhagwant University Page 54


    PEG-6000

    interactions with biological chemicals. These properties make PEG one of the most useful
    molecules for applying osmotic pressure in biochemistry,and biomembranesexperiments, in
    particular when using the osmotic stress technique.

    Polyethylene glycol is also commonly used as a polar stationary phase for gas
    chromatography, as well as a heat transfer fluid in electronic testers.

    PEG has also been used to preserve objects that have been salvaged from underwater, as was
    the case with the warship Vasa in Stockholm,[19] the Mary Rose in England and the Ma'agan
    Michael Ship in Israel. It replaces water in wooden objects, making the wood dimensionally
    stable and preventing warping or shrinking of the wood when it dries. In addition, PEG is
    used when working with green wood as a stabilizer, and to prevent shrinkage.

    PEG is often used (as an internal calibration compound) in mass spectrometry experiments,
    with its characteristic fragmentation pattern allowing accurate and reproducible tuning.

    PEG derivatives, such as narrow range ethoxylates, are used as surfactants.

    PEG has been used as the hydrophilic block of amphiphilic block copolymers used to create
    some polymersomes.

    Industrial uses
    Nitrate ester-plasticized polyethylene glycol is used in Trident II ballistic missile solid rocket
    fuel.

    Dimethyl ethers of PEG are the key ingredient of Selexol, a solvent used by coal-
    burning, integrated gasification combined cycle (IGCC) power plants to remove carbon
    dioxideand hydrogen sulfide from the gas waste stream.

    PEG has been used as the gate insulator in an electric double-layer transistor to induce
    superconductivity in an insulator.

    PEG is also used as a polymer host for solid polymer electrolytes. Although not yet in
    commercial production, many groups around the globe are engaged in research on solid
    polymer electrolytes involving PEG, with the aim of improving their properties, and in
    permitting their use in batteries, electro-chromic display systems, and other products in the
    future.

    Institute of pharmaceutical science & Research centre Bhagwant University Page 55

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