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    Anatomy Notes Leydig

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    jed guico
    Leydig cells and Sertoli cells are the two main cell types in the testes. Leydig cells produce and secrete testosterone and are located in the interstitium. Sertoli cells provide structural and nutritional support to developing sperm cells and are columnar cells extending through the seminiferous tubules. Both cell types have distinct nuclear and cytoplasmic features that support their roles in sperm production and testosterone secretion.

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    Anatomy Notes Leydig

    Uploaded by

    jed guico
    20 views1 page
    Leydig cells and Sertoli cells are the two main cell types in the testes. Leydig cells produce and secrete testosterone and are located in the interstitium. Sertoli cells provide structural and nutritional support to developing sperm cells and are columnar cells extending through the seminiferous tubules. Both cell types have distinct nuclear and cytoplasmic features that support their roles in sperm production and testosterone secretion.

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    Leydig cells and Sertoli cells are the two main cell types in the testes. Leydig cells produce and secrete testosterone and are located in the interstitium. Sertoli cells provide structural and nutritional support to developing sperm cells and are columnar cells extending through the seminiferous tubules. Both cell types have distinct nuclear and cytoplasmic features that support their roles in sperm production and testosterone secretion.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    20 views1 page

    Anatomy Notes Leydig

    Uploaded by

    jed guico
    Leydig cells and Sertoli cells are the two main cell types in the testes. Leydig cells produce and secrete testosterone and are located in the interstitium. Sertoli cells provide structural and nutritional support to developing sperm cells and are columnar cells extending through the seminiferous tubules. Both cell types have distinct nuclear and cytoplasmic features that support their roles in sperm production and testosterone secretion.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
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    LEYDIG CELLS SERTOLI CELLS

     Most functional cells in the interstitium o Basically columnar resting upon the basal lamina
     Synthesize and secrete male sex steroids called and extending upward through the full thickness of
    androgens the epithelium to its free surface
     Testosterone – most abundant androgen released o Thin processes radiate laterally to surround the
    by Leydig cells spermatogenic cells and occupy the interstices
     Exist in small clusters of cells among them
     15-20 um in diameter o Nucleus is ovoid about 9 x 12 um and has large
     Central round nucleus with peripheral nucleolus
    heterochromatin and one or more prominent o Cytoplasm:
    nucleoli  numerous slender mitochondria often oriented
     Cytoplasm: parallel along the long axis of the cell
    - well-developed Golgi Apparatus close to the  lipid droplets
    nucleus which helps elaborate an abundance  occasional lipofuscin pigment granules
    of SER, which contains the enzymes for  sparse RER
    testosterone synthesis  well-developed SER (for secretion and
    - also contains lysosomes, peroxisomes, and modification of steroid hormones)
    conspicuous crystals of Reinke; function is
    unknown Crystalloids of Charcot-Bottcher
    - inclusions peculiar to human sertoli cells
     Interstitial tissue contains numerous small - slender, fusiform structures10 to 25 um long
    lymphatic vessels and abundant interstitial fluid
     The testosterone produced by the leydig cells
    enters the interstitial fluid Functions:
     Androgens enter the systemic circulation through  trophic function in spermatogenesis
    the interstitial fenestrated capillaries near leydig  Help phagocytose and destroy cells that die during
    cells spermatogenesis and residual bodies shed by
    spermatids during spermiogenesis
     Secrete fluids that create a hospitable environment
    for spermatozoa in the seminiferous tubules
     FSH and testosterone stimulate sertoli cells to
    secrete androgen binding protein
     very high concentrations of testosterone are
    required to support the spermatogenic cycle of
    the seminiferous epithelium
     Androgen binding protein concentrates
    tstosterone in the microenvironment of the
    semiferous epthelium
     Sertoli cells also secrete the protein inhibin, which
    provides feedback that helps inhibit FSH production
    by adenohypophysial gonadotropes either by directly
    affecting the hormone producing gonadotropes or
    by affecting the secretion of hypothalamic GnRH

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