PKSolver 2.

0 Non-Compartmental Analysis of Plasma Data after Extravascular Input

Time Unit h Method Linear Trapezoidal

Conc Unit μg/ml Analyst Rusydina Sabila
Dose 500 Date 2019-5-8
Dose Unit mg Time 11:27:07

Time Conc ln(C) AUC AUMC R R_adj

0.5 2.75 1.01160091 0.6875 0.34375
1 6.24 1.83098018 2.935 2.2475
1.5 8.5 2.14006616 6.62 6.995
2 9.81 2.28340227 11.1975 15.0875 -0.9997928 0.99944753
3 7.43 2.00552586 19.8175 36.0425 -0.9997197 0.99915922
4 5.6 1.7227666 26.3325 58.3875 -0.9996426 0.99857047
6 3.19 1.16002092 35.1225 99.9275
8 1.91 0.64710324 40.2225 134.3475

12

10

8
Concentration (μg/ml)

0
0 1 2 3 4 5 6 7 8 9
Time (h)

10
Concentration (μg/ml)

1
Concentrat

1
0 1 2 3 4 5 6 7 8 9
Time (h)

10
Concentration (μg/ml)

1
0 1 2 3 4 5 6 7 8 9
Time (h)
avascular Input

Parameter Unit Value

Lambda_z 1/h 0.273929609
t1/2 h 2.530384292
Tmax h 2
Cmax μg/ml 9.81
Tlag h 0
Clast_obs/Cmax 0.194699286
AUC 0-t μg/ml*h 40.2225
AUC 0-inf_obs μg/ml*h 47.19509418
AUC 0-t/0-inf_obs 0.852260191
AUMC 0-inf_obs μg/ml*h^2 215.5822166
MRT 0-inf_obs h 4.567894615
Vz/F_obs (mg)/(μg/ml) 38.67534256
Cl/F_obs (mg)/(μg/ml)/h 10.59432148
PKSolver 2.0 Non-Compartmental Analysis of Plasma Data after Extravascular Input

Time Unit h Method Linear Trapezoidal

Conc Unit μg/ml Analyst Rusydina Sabila
Dose 200 Date 2019-5-8
Dose Unit mg Time 11:28:46

Time Conc ln(C) AUC AUMC R R_adj

0.5 5.31 1.66959184 1.3275 0.66375 -0.9999942 0.99998644
1 4.62 1.53039471 3.81 2.4825 -0.9999929 0.99998301
1.5 4.02 1.3912819 5.97 5.145 -0.9999911 0.9999777
2 3.5 1.25276297 7.85 8.4025 -0.9999882 0.99996845
3 2.65 0.97455964 10.925 15.8775 -0.9999818 0.99994539
4 2.01 0.69813472 13.255 23.8725 -0.9999728 0.9998913
6 1.16 0.14842001 16.425 38.8725
8 0.66 -0.4155154 18.245 51.1125

4
Concentration (μg/ml)

0
0 1 2 3 4 5 6 7 8 9
Time (h)

10
Concentration (μg/ml)

0.1
 1

Concentrat

0.1
0 1 2 3 4 5 6 7 8 9
Time (h)

10
Concentration (μg/ml)

0.1
0 1 2 3 4 5 6 7 8 9
Time (h)
avascular Input

Parameter Unit Value

Lambda_z 1/h 0.277521768
t1/2 h 2.497631751
Tmax h 0.5
Cmax μg/ml 5.31
Tlag h 0
Clast_obs/Cmax 0.124293785
AUC 0-t μg/ml*h 18.245
AUC 0-inf_obs μg/ml*h 20.62319182
AUC 0-t/0-inf_obs 0.88468362
AUMC 0-inf_obs μg/ml*h^2 78.70742296
MRT 0-inf_obs h 3.816452063
Vz/F_obs (mg)/(μg/ml) 34.94435752
Cl/F_obs (mg)/(μg/ml)/h 9.697819898
PKSolver 2.0 Compartmental Analysis of Plasma Data after Intravenous Bolus Input

Time Unit h
Conc Unit μg/ml Analyst Rusydina Sabila
Dose 200 Date 2019-5-8
Dose Unit mg Time 11:31:39

Time Conc ln(Conc) Conc_pre Residual Weight Parameter Unit

0.5 5.31 1.66959184 6.82741361 -1.5174136 1 C0 μg/ml
1 4.62 1.53039471 4.14103568 0.47896432 1 k10 1/h
1.5 4.02 1.3912819 2.5116651 1.5083349 1
2 3.5 1.25276297 1.52340189 1.97659811 1 Parameter Unit
3 2.65 0.97455964 0.56042824 2.08957176 1 t1/2 h
4 2.01 0.69813472 0.20617003 1.80382997 1 V (mg)/(μg/ml)
6 1.16 0.14842001 0.02790208 1.13209792 1 CL (mg)/(μg/ml)/h
8 0.66 -0.4155154 0.00377614 0.65622386 1 AUC 0-t μg/ml*h
8
AUC 0-inf μg/ml*h
7 Predicted AUMC μg/ml*h^2
Observed MRT h
6 Vss mg/(μg/ml)
Concentration (μg/ml)

5 Diagnostics Value
r obs-pre 0.901979891
4 SS 18.046353312
WSS 18.046353312
3 R^2 0.8012400139
WR^2 0.8012400139
2 SE 1.7342795484
AIC 27.143549054
1 SC 27.302432138

0
0 1 2 3 4 5 6 7 8 9
Time (h)

10

Predicted
Observed
1
Concentration (μg/ml)

0.1

0.01

0.001
 0.1

Concentrat 0.01

0.001
0 1 2 3 4 5 6 7 8 9
Time (h)

Residual Plot
2.5

1.5

1
Residual (μg/ml)

0.5

0
0 1 2 3 4 5 6 7 8 9
-0.5

-1

-1.5

-2
Time (h)
 Value Time Conc_Pre
11.25650204 0.5 6.82741361
1 0.57575758 6.32929177
0.65151515 5.86751244
Value 0.72727273 5.43942411
0.693147181 0.8030303 5.04256871
17.76750888 0.87878788 4.67466752
17.76750888 0.95454545 4.33360806
11.25272591 1.03030303 4.01743199
11.25650204 1.10606061 3.72432384
11.25650204 1.18181818 3.45260058
1 1.25757576 3.20070201
17.76750888 1.33333333 2.96718172
1.40909091 2.75069886
1.48484848 2.5500104
1.56060606 2.36396397
1.63636364 2.19149133
1.71212121 2.03160213
1.78787879 1.8833783
1.86363636 1.74596875
1.93939394 1.61858447
2.01515152 1.50049403
2.09090909 1.39101936
2.16666667 1.28953186
2.24242424 1.1954488
2.31818182 1.10822995
2.39393939 1.02737451
2.46969697 0.95241821
2.54545455 0.88293065
2.62121212 0.81851284
2.6969697 0.75879489
2.77272727 0.70343391
2.84848485 0.65211202
2.92424242 0.60453452
3 0.56042824
3.07575758 0.51953991
3.15151515 0.48163475
3.22727273 0.44649512
3.3030303 0.41391925
3.37878788 0.38372008
3.45454545 0.35572421
3.53030303 0.3297709
3.60606061 0.305711117
3.68181818 0.28340671
3.75757576 0.26272962
3.83333333 0.24356111
3.90909091 0.22579111
3.98484848 0.2093176
4.06060606 0.19404598
4.13636364 0.17988856
4.21212121 0.16676406
4.28787879 0.15459711
4.36363636 0.14331784
4.43939394 0.1328615
4.51515152 0.12316805
4.59090909 0.11418182
4.66666667 0.10585122
4.74242424 0.09812841
4.81818182 0.09096905
4.89393939 0.08433204
4.96969697 0.07817925
5.04545455 0.07247536
5.12121212 0.06718762
5.1969697 0.06228568
5.27272727 0.05774137
5.34848485 0.05352861
5.42424242 0.04962322
5.5 0.04600275
5.57575758 0.04264643
5.65151515 0.03953499
5.72727273 0.03665055
5.8030303 0.03397656
5.87878788 0.03149766
5.95454545 0.02919962
6.03030303 0.02706924
6.10606061 0.0250943
6.18181818 0.02326344
6.25757576 0.02156616
6.33333333 0.01999271
6.40909091 0.01853406
6.48484848 0.01718183
6.56060606 0.01592826
6.63636364 0.01476615
6.71212121 0.01368883
6.78787879 0.0126901
6.86363636 0.01176424
6.93939394 0.01090594
7.01515152 0.01011025
7.09090909 0.00937261
7.16666667 0.0086888
7.24242424 0.00805487
7.31818182 0.00746719
7.39393939 0.00692239
7.46969697 0.00641734
7.54545455 0.00594914
7.62121212 0.0055151
7.6969697 0.00511272
7.77272727 0.0047397
7.84848485 0.0043939
7.92424242 0.00407332
8 0.00377614
PKSolver 2.0 Compartmental Analysis of Plasma Data after Extravascular Input

Time Unit h
Conc Unit μg/ml Analyst Rusydina Sabila
Dose 500 Date 2019-5-8
Dose Unit mg Time 11:34:21

Time Conc ln(Conc) Conc_pre Residual Weight Parameter Unit

0.5 2.75 1.01160091 6.99434741 -4.2443474 1 A μg/ml
1 6.24 1.83098018 8.48221041 -2.2422104 1 Alpha 1/h
1.5 8.5 2.14006616 7.71493297 0.78506703 1 B μg/ml
2 9.81 2.28340227 6.23738802 3.57261198 1 Beta 1/h
3 7.43 2.00552586 3.43999483 3.99000517 1 ka 1/h
4 5.6 1.7227666 1.68639902 3.91360098 1
6 3.19 1.16002092 0.34196319 2.84803681 1 Parameter Unit
8 1.91 0.64710324 0.06163765 1.84836235 1 k10 1/h
k12 1/h
k21 1/h
12 t1/2Alpha h
t1/2Beta h
Predicted t1/2ka h
10 Observed V/F (mg)/(μg/ml)
CL/F (mg)/(μg/ml)/h
V2/F (mg)/(μg/ml)
8
Concentration (μg/ml)

CL2/F (mg)/(μg/ml)/h
Tmax h
Cmax μg/ml
6
AUC 0-t μg/ml*h
AUC 0-inf μg/ml*h
AUMC μg/ml*h^2
4
MRT h

2 Diagnostics Value
r obs-pre 0.5359954431
SS 79.18605004
0 WSS 79.18605004
0 1 2 3 4 5 6 7 8 9 R^2 0.7489148642
Time (h) WR^2 0.7489148642
SE 5.1376405103
10 AIC 44.97440118
SC 45.371608888
Predicted
Observed
Concentration (μg/ml)

1
Concentrat

1
0 1 2 3 4 5 6 7 8 9
Time (h)

Residual Plot
5

2
Residual (μg/ml)

0
0 1 2 3 4 5 6 7 8 9
-1

-2

-3

-4

-5
Time (h)
 Value Time Conc_Pre
10357.50729 0 0
1 0.08080808 1.71943636
10355.06592 0.16161616 3.17177268
1 0.24242424 4.38812779
1.0011138105 0.32323232 5.39639779
0.4040404 6.22156901
Value 0.48484848 6.88600165
1 0.56565657 7.40968705
0 0.64646465 7.81048077
1 0.72727273 8.10431372
0.693147181 0.80808081 8.30538348
0.693147181 0.88888889 8.42632741
0.692376005 0.96969697 8.47837939
21.69741997 1.05050505 8.47151157
21.69741997 1.13131313 8.41456264
0 1.21212121 8.31535371
0 1.29292929 8.18079308
0.99944349 1.37373737 8.01697083
8.482211723 1.45454545 7.82924429
22.97491496 1.53535354 7.62231509
23.0442145 1.61616162 7.40029871
46.06279067 1.6969697 7.16678717
1.998887429 1.77777778 6.92490551
1.85858586 6.67736269
1.93939394 6.42649732
2.02020202 6.1743189
2.1010101 5.92254482
2.18181818 5.67263358
2.26262626 5.42581472
2.34343434 5.18311549
2.42424242 4.94538496
2.50505051 4.71331542
2.58585859 4.48746165
2.66666667 4.2682581
2.74747475 4.05603423
2.82828283 3.85102822
2.90909091 3.65339912
2.98989899 3.46323775
3.07070707 3.28057629
3.15151515 3.10539691
3.23232323 2.93763926
3.31313131 2.77720727
3.39393939 2.62397499
3.47474747 2.47779185
3.55555556 2.33848725
3.63636364 2.20587454
3.71717172 2.07975459
3.7979798 1.95991883
3.87878788 1.84615189
3.95959596 1.73823399
4.04040404 1.63594286
4.12121212 1.53905545
4.2020202 1.44734946
4.28282828 1.36060448
4.36363636 1.2786031
4.44444444 1.20113176
4.52525253 1.12798145
4.60606061 1.0589483
4.68686869 0.99383403
4.76767677 0.93244634
4.84848485 0.87459916
4.92929293 0.82011284
5.01010101 0.76881427
5.09090909 0.72053697
5.17171717 0.67512107
5.25252525 0.63241333
5.33333333 0.59226704
5.41414141 0.55454195
5.49494949 0.51910413
5.57575758 0.48582587
5.65656566 0.45458548
5.73737374 0.42526715
5.81818182 0.39776078
5.8989899 0.37196176
5.97979798 0.34777081
6.06060606 0.32509377
6.14141414 0.3038414
6.22222222 0.2839292
6.3030303 0.26527719
6.38383838 0.24780974
6.46464646 0.23145536
6.54545455 0.21614652
6.62626263 0.20181947
6.70707071 0.18841405
6.78787879 0.17587352
6.86868687 0.1641444
6.94949495 0.1531763
7.03030303 0.14292176
7.11111111 0.1333361
7.19191919 0.12437728
7.27272727 0.11600576
7.35353535 0.10818434
7.43434343 0.10087808
7.51515152 0.09405414
7.5959596 0.08768167
7.67676768 0.0817317
7.75757576 0.07617705
7.83838384 0.0709922
7.91919192 0.06615321
8 0.06163765
PKSolver 2.0 Compartmental Analysis of Plasma Data after Intravenous Bolus Input

Time Unit h
Conc Unit μg/ml Analyst Rusydina Sabila
Dose 200 Date 2019-5-8
Dose Unit mg Time 12:03:09

Time Conc ln(Conc) Conc_pre Residual Weight Parameter Unit

0.5 5.31 1.66959184 5.30990099 9.9009E-05 1 A μg/ml
1 4.62 1.53039471 4.61995363 4.6366E-05 1 Alpha 1/h
1.5 4.02 1.3912819 4.02041966 -0.0004197 1 B μg/ml
2 3.5 1.25276297 3.49921226 0.00078774 1 Beta 1/h
3 2.65 0.97455964 2.65161985 -0.0016199 1
4 2.01 0.69813472 2.00993332 6.6679E-05 1 Parameter Unit
6 1.16 0.14842001 1.15540169 0.00459831 1 k10 1/h
8 0.66 -0.4155154 0.66437808 -0.0043781 1 k12 1/h
k21 1/h
t1/2Alpha h
6 t1/2Beta h
C0 μg/ml
Predicted V (mg)/(μg/ml)
5 Observed CL (mg)/(μg/ml)/h
V2 (mg)/(μg/ml)
CL2 (mg)/(μg/ml)/h
4
Concentration (μg/ml)

AUC 0-t μg/ml*h

AUC 0-inf μg/ml*h
AUMC μg/ml*h^2
3
MRT h
Vss mg/(μg/ml)
2
Diagnostics Value
r obs-pre 0.9999988722
1 SS 4.374905E-05
WSS 4.374905E-05
R^2 0.9999995182
0 WR^2 0.9999995182
0 1 2 3 4 5 6 7 8 9 SE 0.0033071533
Time (h) AIC -72.29632479
SC -71.97855862
10

Predicted
Observed
Concentration (μg/ml)

0.1
 1

Concentrat

0.1
0 1 2 3 4 5 6 7 8 9
Time (h)

Residual Plot
0.006

0.004

0.002
Residual (μg/ml)

0
0 1 2 3 4 5 6 7 8 9

-0.002

-0.004

-0.006
Time (h)
 Value Time Conc_Pre
0.032700007 0.5 5.30990099
0.754226578 0.57575758 5.19901883
6.071656535 0.65151515 5.09047918
0.276581665 0.72727273 4.98423105
0.8030303 4.88022466
Value 0.87878788 4.77841138
0.277523144 0.95454545 4.6787437
0.001617184 1.03030303 4.58117522
0.751667915 1.10606061 4.48566061
0.919017177 1.18181818 4.39215556
2.506121224 1.25757576 4.3006168
6.104356542 1.33333333 4.21100203
32.76348599 1.40909091 4.12326991
9.092625624 1.48484848 4.03738005
0.070489373 1.56060606 3.95329297
0.0529846 1.63636364 3.87097008
19.59392163 1.71212121 3.79037363
21.99584677 1.78787879 3.71146677
79.42822247 1.86363636 3.63421343
3.611055455 1.93939394 3.55857835
32.83397536 2.01515152 3.48452708
2.09090909 3.41202592
2.16666667 3.3410419
2.24242424 3.2715428
2.31818182 3.20349711
2.39393939 3.13687401
2.46969697 3.07164334
2.54545455 3.00777564
2.62121212 2.94524205
2.6969697 2.88401437
2.77272727 2.82406502
2.84848485 2.76536698
2.92424242 2.70789387
3 2.65161985
3.07575758 2.59651964
3.15151515 2.54256853
3.22727273 2.48974231
3.3030303 2.43801731
3.37878788 2.38737039
3.45454545 2.33777887
3.53030303 2.28922058
3.60606061 2.24167382
3.68181818 2.19511737
3.75757576 2.14953043
3.83333333 2.10489268
3.90909091 2.06118421
3.98484848 2.01838556
4.06060606 1.97647765
4.13636364 1.93544185
4.21212121 1.89525988
4.28787879 1.85591388
4.36363636 1.81738637
4.43939394 1.77966022
4.51515152 1.74271868
4.59090909 1.70654534
4.66666667 1.67112417
4.74242424 1.63643944
4.81818182 1.60247578
4.89393939 1.56921813
4.96969697 1.53665175
5.04545455 1.50476221
5.12121212 1.4735354
5.1969697 1.44295748
5.27272727 1.41301494
5.34848485 1.38369451
5.42424242 1.35498323
5.5 1.3268684
5.57575758 1.2993376
5.65151515 1.27237864
5.72727273 1.24597963
5.8030303 1.2201289
5.87878788 1.19481503
5.95454545 1.17002684
6.03030303 1.14575338
6.10606061 1.12198395
6.18181818 1.09870805
6.25757576 1.07591541
6.33333333 1.05359598
6.40909091 1.03173991
6.48484848 1.01033756
6.56060606 0.98937949
6.63636364 0.96885647
6.71212121 0.94875945
6.78787879 0.92907956
6.86363636 0.90980814
6.93939394 0.89093669
7.01515152 0.8724569
7.09090909 0.85436064
7.16666667 0.83663991
7.24242424 0.81928694
7.31818182 0.80229406
7.39393939 0.7856538
7.46969697 0.76935883
7.54545455 0.75340198
7.62121212 0.73777622
7.6969697 0.72247468
7.77272727 0.70749063
7.84848485 0.69281745
7.92424242 0.67844871
8 0.66437808
 Kadar
t (jam)
suspensi oral injeksi intravena
0.5 2.75 5.31 IV ORAL
1 6.24 4.62 11.25650204 22.974914959
1.5 8.5 4.02 11.25650204 23.044214501
2 9.81 3.5
3 7.43 2.65 Fabs =
4 5.6 2.01
6 3.19 1.16
8 1.91 0.66
 AUC
Sukarelawan
Kapsul A Kapsul B Kapsul C Kapsul STD
1 14.1 19.1 9.6 15.8
2 20.2 20 10.6 19
3 19 17.5 14.6 19.3
4 13.2 20.3 13.1 18.4
5 13.5 17.3 10.4 17.2
6 17.9 17.4 8.3 16.5
7 12.4 17.2 14.5 17.9
8 15.8 16.9 11.4 17.5