Sex Linked Worksheet

Name: _______________________________ Per: ____ Desk: ________ Sec: ____ Date: _______________
Sex-Linked Traits Worksheet

Background Information:
Sex-linked traits are those whose genes are found on the X chromosome but not
on the Y chromosome. In humans the X chromosomes are much larger than the Y
chromosome and contains thousands of more genes than the Y chromosome. For each
of the genes that are exclusively on the X chromosomes, females, who are XX, would
obviously have two alleles. Males, who are XY, would have only one allele. Thus
females with one recessive allele and one dominant allele, for a gene that is unique to
the X chromosome, will always display the dominant phenotype. However, a male with
a recessive allele for a gene unique to the X chromosome will always exhibit that
recessive trait because there is no other corresponding allele on the Y chromosome.
In humans, each of two different sex-linked genes has a defective recessive
allele that causes a disease. The diseases are hemophilia and colorblindness. In
hemophilia, the defective allele prevents the synthesis of a factor needed for blood
clotting. In colorblindness, the defective allele prevents a person from seeing certain
colors.
Use the information below to answer the following questions.
XH- X chromosome with normal dominant allele (no hemophilia)

Xh - X chromosome with recessive hemophilia allele
Y - Y chromosome (does not contain comparable gene)
XB - X chromosome with normal dominant allele (not colorblind)
Xb - X chromosome with recessive colorblind allele
Y -Y chromosome (does not contain comparable gene)
1. Write the genotypes for the following phenotypes of red-green color

blindness.
B
a. normal male ______X Y_______
B B
b. normal female carrying no colorblind alleles (Homozygous) ___ X X _____
b
c. colorblind male ___________ X Y______________
B b
d. normal female carrying the colorblind allele (Heterozygous) ____ X X _____
b b
e. colorblind female ______ X X ________
2. XBXB x XbY XB XB
a. What proportion/percent of the male children
are colorblind? _____0%_______ X b XB Xb XBXb
b. What proportion/percent of the female children Y XBY XBY

are colorblind?_____0%_______
3. XBXb x XBY
XB Xb
a. What proportion of the male children are B B
X X BX XBXb
colorblind? ______50%________
b. What proportion of the female children are

colorblind?________0%_______
Y XBY XbY
4. What is the probability that a colorblind woman who marries a man with normal
vision will have a colorblind child? ______50%________
Xb Xb
XbXb x XB Y B b
XBXb
XB X X
Y XbY XbY
5. A normal-sighted woman (whose father was colorblind)

B b b
marries a colorblind man. X X x X Y
XB Xb
a. What is the probability that they will have a son
who is colorblind? _____50%____ B b
Xb X X XbXb
b. What is the probability that they will have a

colorblind daughter? ____50%____
Y XBY XbY
For the following Sex-Linked Punnett Squares:
H= normal blood clotting

h=hemophilia
6. XHXh x XHY
a. What is the probability that any of their offspring

XH Xh
will have hemophilia? _______25%________
H XHXH XHXh
X
H
Y X Y XhY
7. A woman who is a carrier for hemophilia marries a hemophiliac man.

XH Xh x XhY
XH Xh
a. What proportion of the male children are
hemophiliacs?_______50%_______ H h
XhXh
Xh X X
b. What proportion of the female children are
hemophiliacs?______ 50%_______
Y XHY XhY
8. A phenotypically normal man marries a homozygous normal woman.

XHXH x XHY
XH XH
H H
a. What is the probability that any of their children X X HX XHXH
will be hemophiliacs?________0%___________
Y XHY XHY
9. A phenotypically normal woman has phenotypically normal parents. However, she
has a hemophiliac brother.
(Mom is carrier) (Dad) Brother
XH Xh x XH Y XhY (got Xh from Mom)
XH Xh
a. What are her chances of being a carrier for
H XHXH XHXh
hemophilia?______50%________ X
Y XHY XhY
ANSWER THE FOLLOWING QUESTIONS USING YOUR KNOWLEDGE OF SEX-

LINKED TRAITS, THE BACKGROUND INFORMATION AND YOUR NOTES.
10. What is a sex-linked trait?
Those traits whose genes are found on the X chromosome but NOT on the Y
chromosome
11. Why must males inherit colorblindness or hemophilia from their mothers?
Because their mother gives them their X chromosome.
12. Why is colorblindness or hemophilia more common in males than in

females?
Because the trait is recessive and since they only have one allele, there is no
Other allele expressed. So what they have on their one X chromosome is what
Is expressed. Females can have one recessive allele but it is masked by the
Dominant normal allele.

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What is a sex-linked trait?

What is a sex-linked trait?

Why must males inherit colorblindness or hemophilia from their mothers?

Why must males inherit colorblindness or hemophilia from their mothers?

Name: _______________________________ Per: ____ Desk: ________ Sec: ____ Date: _______________

Sex-Linked Traits Worksheet

Use the information below to answer the following questions.

XH- X chromosome with normal dominant allele (no hemophilia)

1. Write the genotypes for the following phenotypes of red-green color

b. What proportion/percent of the female children Y XBY XBY

b. What proportion of the female children are

5. A normal-sighted woman (whose father was colorblind)

b. What is the probability that they will have a

H= normal blood clotting

a. What is the probability that any of their offspring

7. A woman who is a carrier for hemophilia marries a hemophiliac man.

8. A phenotypically normal man marries a homozygous normal woman.

ANSWER THE FOLLOWING QUESTIONS USING YOUR KNOWLEDGE OF SEX-

10. What is a sex-linked trait?

Because their mother gives them their X chromosome.

12. Why is colorblindness or hemophilia more common in males than in

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Name: _________________ Per: Desk: Sec: Date: _