Pharmacology of Metabolic Drugs: Nurlaili Susanti
Pharmacology of Metabolic Drugs: Nurlaili Susanti
Metabolic Drugs
Nurlaili Susanti
Learning Objective:
14
Complications of Insulin Therapy
Contraindication:
1. Hepatic impairment
2. Renal impairment
3. Alcoholism
4. Heart failure
4. Thiazolidinediones/ TZDs
(Glitazones)
Sitagliptin
Inactive Inactive
GLP-1 GIP
Incretin mimetics and DPP-4 inhibitors:
major differences
Hypoglycaemia No No
37
Sodium-glucose transport
(SGLT)-2 inhibitor
PANCREAS
1. GLUCOSE
PRODUCTION 3. PERIPHERAL
GLUCOSE UPTAKE
Biguanides 2. INSULIN SECRETION
Thiazolidinediones
Thiazolidinediones Sulfonylureas
Biguanides
Meglitinides
INTESTINE
5. INTESTINAL HORMONES
4. GLUCOSE Incretin
ABSORPTION
alpha-glucosidase inhibitors 41
Antidislipidemic Drugs
- STATIN
- DERIVAT FIBRAT ACID
- BILE ACID
SEQUESTRAN
- NIKOTINIC ACID
- INHIBITOR OF
INTESTINAL
STEROL ABSORBTION
- FISH OIL
1. STATIN
• Mevastatin, Lovastatin, Pravastatin, Simvastatin,
Atorvastatin, Rosuvastatin, Fluvastatin
Effect of Statin on LDL, HDL and Trigliserid level
The other effect of Statin (based on invitro study)
• Derivat: Ezetimibe
Mechanism : inhibit cholesterol absorption in intestine
Pharmacokinetic
• Easily absorbed and conjugated in the intestine to active
glucoronide
• Undergo enterohepatic circulation
• Excretion through feces