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    Introduction To Vitamin D

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    aboelsoud mohamed
    Vitamin D is a fat-soluble vitamin that is obtained through dietary sources like fatty fish or through dermal synthesis in the skin upon exposure to sunlight. It requires enzymatic conversion in the liver and kidneys to become biologically active. Vitamin D plays an essential role in bone health by maintaining adequate calcium absorption, and deficiency can lead to soft bones and rickets in children or osteomalacia in adults. While sunlight is the major natural source of vitamin D, darker-skinned individuals and those in low sunlight areas are at higher risk of deficiency. The Scientific Advisory Committee on Nutrition recommends a minimum serum level of 25 nmol/L to prevent bone diseases, though higher levels may be needed for optimal bone

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    Introduction To Vitamin D

    Uploaded by

    aboelsoud mohamed
    64 views2 pages
    Vitamin D is a fat-soluble vitamin that is obtained through dietary sources like fatty fish or through dermal synthesis in the skin upon exposure to sunlight. It requires enzymatic conversion in the liver and kidneys to become biologically active. Vitamin D plays an essential role in bone health by maintaining adequate calcium absorption, and deficiency can lead to soft bones and rickets in children or osteomalacia in adults. While sunlight is the major natural source of vitamin D, darker-skinned individuals and those in low sunlight areas are at higher risk of deficiency. The Scientific Advisory Committee on Nutrition recommends a minimum serum level of 25 nmol/L to prevent bone diseases, though higher levels may be needed for optimal bone

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    Introduction to Vitamin D

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    Introduction to Vitamin D

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    Vitamin D is a fat-soluble vitamin that is obtained through dietary sources like fatty fish or through dermal synthesis in the skin upon exposure to sunlight. It requires enzymatic conversion in the liver and kidneys to become biologically active. Vitamin D plays an essential role in bone health by maintaining adequate calcium absorption, and deficiency can lead to soft bones and rickets in children or osteomalacia in adults. While sunlight is the major natural source of vitamin D, darker-skinned individuals and those in low sunlight areas are at higher risk of deficiency. The Scientific Advisory Committee on Nutrition recommends a minimum serum level of 25 nmol/L to prevent bone diseases, though higher levels may be needed for optimal bone

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    64 views2 pages

    Introduction To Vitamin D

    Uploaded by

    aboelsoud mohamed
    Vitamin D is a fat-soluble vitamin that is obtained through dietary sources like fatty fish or through dermal synthesis in the skin upon exposure to sunlight. It requires enzymatic conversion in the liver and kidneys to become biologically active. Vitamin D plays an essential role in bone health by maintaining adequate calcium absorption, and deficiency can lead to soft bones and rickets in children or osteomalacia in adults. While sunlight is the major natural source of vitamin D, darker-skinned individuals and those in low sunlight areas are at higher risk of deficiency. The Scientific Advisory Committee on Nutrition recommends a minimum serum level of 25 nmol/L to prevent bone diseases, though higher levels may be needed for optimal bone

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
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    Vitamin D: introduction

    Vitamin D is a fat-soluble vitamin. Very few foods naturally contain vitamin D (fatty fish
    livers are the exception), so dermal synthesis is the major natural source of the vitamin.
    Vitamin D from the diet or dermal synthesis is biologically inactive and requires enzymatic
    conversion to active metabolites. Vitamin D is converted enzymatically in the liver to 25-
    hydroxyvitamin D (25[OH]D), the major circulating form of vitamin D, and then in the
    kidney to 1,25-dihydroxyvitamin D, the active form of vitamin D.

    Vitamin D is well known for its essential role in maintaining healthy bones. Deficiency
    causes bones to become soft and weak: a condition known as rickets in children and
    osteomalacia in adults. The majority of vitamin D is produced via skin synthesis under the
    action of sunlight, with smaller amounts from dietary sources such as oily fish, meat and
    eggs. Adequate exposure to ultraviolet (UV) light is therefore necessary to maintain levels.

    Other physiological roles of vitamin D in maintaining health are now recognized. Some
    evidence suggests that vitamin D deficiency is associated with increased risk of
    cardiovascular diseases, some cancers, type 2 diabetes and multiple sclerosis. In addition,
    there is also some evidence that low levels are associated with increased risk of all cause
    mortality. It is also possible that the relationship is mediated through the association of
    vitamin D deficiency with other risk factors, such as lack of physical activity and obesity.

    Vitamin D production is in part dependent on skin pigmentation with paler-skinned


    individuals able to synthesis vitamin D more efficiently under UV exposure; therefore,
    darker-skinned individuals who move to a region experiencing low sunlight are at particular
    risk of deficiency.
    The Scientific Advisory Committee on Nutrition (2016) recommends that individuals should
    have serum concentrations of vitamin D above a ‘population protective level’ of 25 nmol/L
    throughout the year. This concentration is considered sufficient to prevent rickets in children
    and osteomalacia in adults. Elsewhere, serum concentrations below 50 nmol/L are
    considered to be deficient, and higher concentrations such as 75 nmol/L have been
    recommended for optimal bone health.

    There have been few well-conducted randomized controlled trials of vitamin D


    supplementation in healthy adults and those that have been performed have not shown clear
    evidence of a benefit from taking supplements. In a recent meta-analysis found that vitamin
    D supplementation alone did not reduce cancer incidence or mortality. The potential risks of
    excessive sun exposure must also be considered in the context of attempts to increase vitamin
    D levels. Clearer evidence is required regarding the health effects, safety and practicality of
    increasing population vitamin D levels.

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