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    HH

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    yasser
    This document discusses small molecule drug discovery and the challenges involved. It notes that small molecule drug design targets specific macromolecular receptors and several approaches have been developed over time, including computer-aided techniques and high-throughput screening. However, drug discovery is an iterative process where thousands of molecules must be tested to find one with the desired properties, and 90% of experiments fail. The document also discusses polymers and how a research chemist unexpectedly created a new polymer that could have various applications.

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    HH

    Uploaded by

    yasser
    55 views2 pages
    This document discusses small molecule drug discovery and the challenges involved. It notes that small molecule drug design targets specific macromolecular receptors and several approaches have been developed over time, including computer-aided techniques and high-throughput screening. However, drug discovery is an iterative process where thousands of molecules must be tested to find one with the desired properties, and 90% of experiments fail. The document also discusses polymers and how a research chemist unexpectedly created a new polymer that could have various applications.

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    This document discusses small molecule drug discovery and the challenges involved. It notes that small molecule drug design targets specific macromolecular receptors and several approaches have been developed over time, including computer-aided techniques and high-throughput screening. However, drug discovery is an iterative process where thousands of molecules must be tested to find one with the desired properties, and 90% of experiments fail. The document also discusses polymers and how a research chemist unexpectedly created a new polymer that could have various applications.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    55 views2 pages

    HH

    Uploaded by

    yasser
    This document discusses small molecule drug discovery and the challenges involved. It notes that small molecule drug design targets specific macromolecular receptors and several approaches have been developed over time, including computer-aided techniques and high-throughput screening. However, drug discovery is an iterative process where thousands of molecules must be tested to find one with the desired properties, and 90% of experiments fail. The document also discusses polymers and how a research chemist unexpectedly created a new polymer that could have various applications.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
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    Humankind has been in the business of discovering drugs for thousands of years.

    At
    present, small-molecule drug design is based on specific macromolecular receptors as
    targets for inhibition or modulation. To this end, a number of clever approaches have
    evolved over time: computer-aided techniques including structure-activity
    relationships and synthesis, high-throughput screening, quantitative structure-activity
    relationships, hypotheses derived from ligand- and/or structure-based information and
    focused library approaches. In recent years, several alternative strategies have
    appeared in the form of the emerging paradigms of polypharmacology, systems
    biology and personalized medicine. These innovations point to key challenges and
    breakthroughs likely to affect the future of small-molecule drug discovery.
    Every molecule that you make during a drug discovery program is a molecule that has
    never been made in the universe ever you are completely and entirely in no man’s
    land when you are doing this work.
    Large molecules cannot get inside the cell so large molecules can influence diseases
    by interacting with things that are on the surface of the cell, small molecules can get
    inside the cell we can interact with the machinery inside of the cells we can disrupt
    certain process within the cells
    The challenge of drug discovery is finding that molecule and it’s often a needle in a
    hast stack and we will make thousands of molecules in order to find the right one
    which has exactly the same properties that we were searching for and it’s a very
    iterative process you test them in your biological asses you look at their metabolism
    properties and then based on that you go back and make the next molecule that you
    think will be best for your study
    90% of the experiments that you run don’t work, a successful scientist is the one that
    spends his time talking about how to make it work because 10% of the time it does
    but you have to run all ten experiments to figure out which one is the one that will
    ultimately help you refine your hypothesis
    Vue les caracteristique uniques du C6’CH3) new molecule that could eventually
    have applications in medicine, food science and other fields
    La majorities des polymers crees au cours de l’histoire en etait decouvert par le
    hasard When research chemist Jeannette García found a candy-size
    lump of white material in a flask she had recently used, she had no
    idea what she had created. The material stuck firmly to the glass, so
    she used a hammer to break it free. But when she turned the hammer
    on the material itself, it refused to crack. It was in that moment that
    she realized that she made a new polymere
    But what if we already know what we are aiming for? Knowing the
    exact form and properties of the molecule that we are manuplating
    can give us astonishing results Vue les caracteristique uniques du C6’CH3) et
    sa forme crystalline cette molecule sera un sujet d’etude parfait pour la creation de
    nouvelle polymere in the near future
    Global demand for durable, recyclable plastics is expected to soon
    increase. By 2015, for example, both Europe and Japan will require
    that 95 percent of car parts produced there be recyclable.
    But she believes that the new thermoset could also eventually extend
    into a range of applications—anticorrosive and antimicrobial
    coatings, drug delivery, adhesives, 3-D printing, water purification,
    among others.
    Humans have been creating synthetic polymers for the better part of a century,
    and they can now be found in everything from your steering wheel and favorite
    polyester suit to your computer and airplanes. But new polymer-forming chemical
    reactions like this one are extremely rare.

    "Most [polymer] discoveries were made between 1930 and 1950," Garcia
    told Mashable.

    Polymers are essentially macromolecues made up of 10,000 or more atoms and


    they occur in nature (rubber) and have been synthesized in the lab (Polystyrene).

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