1) All trans retinoic acid is used in the treatment of tumor associated with?

a. BCR-ABL
b. PML – RARA
c. cMYC
d. CEBPA

2) A 11-year-old boy cam with history of cough for 15 days. On examination he was
found to have cervical lymphadenopathy. Lymph node biopsy showed the below
finding. Which of the following is the most appropriate diagnosis?

a. Leprosy
b. Sarcoidosis
c. TB
d. Syphilis
3) A 30-year-old women came with complaints of easy fatigability, exertional dyspnea
and weight loss. She also complaints of frequent fall. Physical examination revealed
there was bilateral decrease in vibration sense. Her hemoglobin levels were 8.2g%.
She was treated with folate. Her anemia improved but neurological symptoms
worsened. Which of the following is the most probable reason for her condition?
a. Folate not absorbed
b. Unmasked pyridoxine deficiency
c. Deficiency of folate reductase in CNS
d. Folate therapy caused rapid use of B12 stores aggravating symptoms

4) A 25-year-old man presents for a routine physical examination. The patient is tall (6
ft, 5 in) and on examination he was found to have an early diastolic murmur. His
family pedigree is as given below. Which of the following is the mode of inheritance
by which the disease is likely to be transmitted?
 a. AD
b. AR
c. XLR
d. XLD

5) Meiosis or reduction division occurs in which of the following cells after birth?
a. Adrenal gland
b. Adult ovary
c. Prepubertal testis
d. Prostate
6) Which of the following factors play a major role in initiation of thrombus formation?
a. Vasoconstriction
b. Coagulation cascade activation
c. Platelets activation
d. Endothelial injury

7) 33-year-old man presents with a 5-week history of calf pain and swelling and low-
grade fever. Serum levels of creatine kinase are elevated. A muscle biopsy reveals
numerous eosinophils also she had peripheral blood eosinophilia. Which of the
following interleukins is primarily responsible for the increase in eosinophils in this
patient?
a. IL2
b. IL4
c. IL1
d. IL6
8) Which of the following is the etiology of werner syndrome?
a. Telomerase lengthening
b. Lamin mutation
c. Lipid peroxidation
d. DNA helicase defect

9) A 45-year-old person who is a chronic smoker came to the clinic with complaints of
cough. The physician examines the patient and take a biopsy. The picture in the
biopsy was as the description below. Which of the following cellular changes has
happened in this patient?

a. Hyperplasia
b. Dysplasia
c. Metaplasia
d. CIN 3
10) A 5 year old male child presented to the clinic with history of recurrent infections.
On examination the child had rashes as shown below. Routine blood investigations
revealed the patient had low platelets. Which of the following is the probable
diagnosis in the kid?

a. Job syndrome
b. Wiskott Aldrich syndrome
c. Henoch scholein purpura
d. ….
11) Which of the following is the correct statement related to Huntington's Chorea?
a. It is a tri-nucleotide expansion mutation related disorder
b. There is loss of function type of mutation
c. There are abnormal repeats of CUG
d. Abnormality is seen due to mutation in Chromosome 6

12) Graft used from an identical twin is called as?

a. Xenograft
b. Allograft
c. Autograft
d. Isograft
13) A patient admitted in the ICU was initiated on Warfarin treatment, which of the
clotting factor would be affected?
a. Factor 2
b. Factor 6
c. Factor 12
d. Factor 9

14) A 10-year-old boy, presents with complaints of fatigue and abdominal pain after
playing football. On detailed history taking he also complaints of painful swelling of
digits in the past. On USG of abdomen he was found to have a small spleen. Which of
the following is the most likely diagnosis?
a. Acute pancreatitis
b. Sickle cell anemia
c. Iron deficiency anemia
d. ….
15) Why is CPD better than ACD for storage of blood?
a. Because it’s less acidic
b. Improves oxygen transport
c. Hypertonicity of blood
d. More citrate ions

16) A 25-year-old male presented with a 2cm thyoid nodule. A throidectomy was done.
The histology picture is given below. What could be the diagnosis?

a. Papillary Carcinoma thyroid

b. Follicular adenoma
c. Graves disease
d. Adenomatous goiter
17) A 30-year-old came with complaints of thyroid swelling. On investigations her TSH
levels were found to be elevated. Post operative HPE reports showed lymphocytic
infiltration and hurthle cells. Which of the following is the most likely diagnosis?
a. Graves disease
b. Follicular carcinoma
c. Hashimoto thyroiditis
d. Medullary carcinoma thyroid

18) Loss of foot process is classical in case of?

a. Membranous glomerulonephritis
b. Minimal change disease
c. IgA nephropathy
d. Diabetic nephropathy
19) A 51-year-old person came with complaints of hematuria to the clinic. On
examination he was normotensive and had pedal edema. Investigations revealed the
patient had no glycosuria and had a creatinine value of 9mg%. Renal biopsy is as
shown below. Which of the following investigations one should do to identify the
etiology of the disease?

a. ANA
b. Anti GBM Antibodies
c. HIV RNA
d. Urine Immunoelectrophoresis

20) Which of the following disease will have bulky friable cardiac vegetations?
a. Libman Sachs endocarditis
b. Infective endocarditis
c. Rheumatic carditis
d. NBTE
21) Which of the following will be seen on cardiac biopsy of a patient who had an post
MI reperfusion injury?
a. Waviness of fibres
b. Eosniophilic contraction bands
c. Neutrophils in cardiac muscle
d. Swelling of cells

22) A 20 year old presented with swelling in the wrist joint for 2 years duration. HPE
showed spindle shaped cells and verocay bodies. Which of the following is the
diganois?
a. Neurofibroma
b. Schwannoma
c. Lipoma
d. Dermoid cyst
23) A 35-year-old heterosexual patient diagnosed with HIV had history of chronic watery
diarrhea. Colonoscopic biopsy is shown as below. Which of the following is your
most probable diagnosis?

a. Giardia
b. Cryptosporidium
c. Microspora
d. CMV

24) A 5 year old kid presented with history of blood in stools. On examination there was
a polypoidal mass in rectum, biopsy of which is shown as below. Your most probable
diagnosis?
 a. Villous adenoma
b. Juvenile polyp
c. Vascular malformation
d. Serrated adenoma

25) A 30 year old male came with complaints of swelling around the Knee joint. Histo
pathological examination of the swelling demonstrated many giant cells interspersed
with mono-nuclear cells. Your most probable diagnosis is?
a. Osteosarcoma
b. Chondrosarcoma
c. Ewings sarcoma
d. Giant cell tumour
26) Which of the following is true about PAN?
a. Microscopy shows fibrinoid necrosis in large arteries
b. ANCA is positive
c. 30% people have HbsAg positive
d. Patient has hypogammaglobulinemia

27) A 40-year-old person presented with 10X8 cm swelling in retroperitoneum, biopsy

form the lesion is as shown below. Molecular analysis demonstrated t(12,16). Which
of the following is your most probable diagnosis?

a. Myxoid liposarcoma
b. Lipoma
c. Synovial sarcoma
d. Pleomorphic sarcoma
28) 20-year-old presented to the clinic with history of malabsorption diarrhea and poor
appetite. vomiting, poor appetite. Duodenal Biopsy of the patient showed crypt
hyperplasia, villi atrophy, CD8+ cells in lamina propria. Your most probable diagnosis
is.
a. Environmental enteropathy
b. Celiac disease
c. Whipples disease
d. Chronic Pancreatitis

29) A 40-year-old women presented to the clinic with a 4 cm mass in the upper outer
quadrant. Biopsy from the mass showed densely packed cells with bland nuclei and
mucin infiltrating the stroma. Which of the following is your diagnosis?
a. Colloid carcinoma
b. Tubular carcinoma
c. Papillary carcinoma
d. Medullary carcinoma
30) A 35-year-old woman with a long history of dyspnea, chronic cough, sputum
production, and wheezing dies of respiratory failure following a bout of lobar
pneumonia. She was not a smoker or alcoholic. The lung at autopsy is shown in the
image. Which of the following underlying conditions was most likely associated with
the pathologic changes shown here?

a. Mutation in dynein arms

b. Cystic fibrosis
c. Alpha 1 antitrypsin deficiency
d. Antibodies against type 4 collagen
31) A 23-year-old male presented to the clinic with history of fatigue and tiredness. On
investigation he was found to have Hb values of – 9gm%, MCV of 101 FL. Peripheral
smear examination showed macrocytic RBC and hypersegmented neutrophils. Which
of the following is the most likely etiology?
a. Lead poisoning
b. Iron deficiency anemia
c. Chronic alcoholism
d. Hemolytic anemia

32) Which of the following infection is common within 1-4 months post transplant?
a. CMV
b. Herpes
c. Varicella
d. EBV