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    A Clinician's Guide To Oral Extended-Release Drug Delivery Systems in Epilepsy

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    JANNIE BELLE RODRIGUEZ
    This document discusses the benefits of oral extended-release drug delivery systems for treating epilepsy. It notes that oral administration remains dominant and extended-release systems can improve adherence, achieve better seizure control, and reduce toxicity by allowing reduced dosing frequencies. While extended-release formulations may enhance patient convenience and adherence, formal studies are still needed to demonstrate their financial impact through reducing costs associated with care and hospitalization.

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    A Clinician's Guide To Oral Extended-Release Drug Delivery Systems in Epilepsy

    Uploaded by

    JANNIE BELLE RODRIGUEZ
    24 views1 page
    This document discusses the benefits of oral extended-release drug delivery systems for treating epilepsy. It notes that oral administration remains dominant and extended-release systems can improve adherence, achieve better seizure control, and reduce toxicity by allowing reduced dosing frequencies. While extended-release formulations may enhance patient convenience and adherence, formal studies are still needed to demonstrate their financial impact through reducing costs associated with care and hospitalization.

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    This document discusses the benefits of oral extended-release drug delivery systems for treating epilepsy. It notes that oral administration remains dominant and extended-release systems can improve adherence, achieve better seizure control, and reduce toxicity by allowing reduced dosing frequencies. While extended-release formulations may enhance patient convenience and adherence, formal studies are still needed to demonstrate their financial impact through reducing costs associated with care and hospitalization.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    24 views1 page

    A Clinician's Guide To Oral Extended-Release Drug Delivery Systems in Epilepsy

    Uploaded by

    JANNIE BELLE RODRIGUEZ
    This document discusses the benefits of oral extended-release drug delivery systems for treating epilepsy. It notes that oral administration remains dominant and extended-release systems can improve adherence, achieve better seizure control, and reduce toxicity by allowing reduced dosing frequencies. While extended-release formulations may enhance patient convenience and adherence, formal studies are still needed to demonstrate their financial impact through reducing costs associated with care and hospitalization.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
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    A Clinician's Guide to Oral Extended-Release Drug

    Delivery Systems in Epilepsy


    James W. Wheless, MD  and Stephanie J. Phelps, PharmD

    Clinical Effectiveness: Oral administration will remain the dominant route of AED delivery to treat
    epilepsy, and oral Extended Release systems are a valuable tool for achieving improved adherence and
    seizure control, and reduced toxicity.

    Patient acceptance: Extended-release formulations can allow for reduction in dose frequency, which
    may enhance convenience and thereby improve adherence.

    Patient adherence: The main benefit is that use of ER formulations improves adherence, which may
    reduce downstream direct and indirect costs associated with care and hospitalization. However, formal
    studies on the financial impact of ER formulations are lacking and are needed.

    Bioequivalence: There are clear benefits for the use of ER formulations compared with IR formulations,
    and that ER formulations should be used for most patients with epilepsy, when appropriate for the
    patient, and when available for their prescribed medication.

    Cost: In general, compared with IR formulations, the manufacturing process and development of ER
    formulations are more technologically complex and time-consuming, consequently translating into
    higher production costs.

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