Trends and Determinants of Maternal Mortality in Mizan-Tepi University Teaching and Bonga General Hospital From 2011 - 2015: A Case Control Study
Trends and Determinants of Maternal Mortality in Mizan-Tepi University Teaching and Bonga General Hospital From 2011 - 2015: A Case Control Study
Trends and Determinants of Maternal Mortality in Mizan-Tepi University Teaching and Bonga General Hospital From 2011 - 2015: A Case Control Study
Societies that have achieved the lowest level of maternal didn’t include the assessment of admission and status of
mortality through preventing pregnancies, reducing incidence mother (dead or alive) during discharge were excluded.
of certain pregnancy complications, and having adequate
Sample size was determined using epi-info version 7 by
facilities and well trained staff to treat the complications
taking the following assumptions: 95% CI, and 90% power,
[8-12].
odds ratio of 0.27 (odds of women having less than 24 labour
Ethiopia is making progress to achieve MDG 5a by reducing length over odds of women having greater than 24hr labour
MMR by 69% from 1990 MMR, even though there are length) from study done in Tigray region, case to control ratio
inconsistencies between figures at international, national level 1:4 and the prevalence of exposure among controls were
and different regional data’s. Between1st July 2010 to 30th 97.6% (proportion of controls delivered in less than 24hr)
June 2012 there were an increase of MMR in public hospitals taken from unmatched case control study done in Tigray
of Tigray regional state. The 2011 EDHS (676/100,000) shows regional state [14]. A total of 975 charts, 195 cases and 780
that there is bit increment of MMR from 2005 EDHS controls were planned to include in the study. But due to poor
(673/100,000), even though the 95 % CI is coinciding. 2005 registration and shortage of sample, we included 595 samples,
EDHS report (673/100,000) and joint estimation by WHO, 119 cases and 476 controls [15,16].
UNICEF, UNFPD and world bank in same year (740/100,000)
Records of both cases and controls were selected from
have wide variation [7,13-16].
delivery ward, operation theatre, PNC ward; gynecologic ward
Although our country reduces the maternal death from which full fills the inclusion and exclusion criteria of the study
previous times as the report of international organizations, still [17-20].
the number of death that occurs currently is high as WHO
First cases were identified from log book or registration
maternal death classification. In contrary, some hospital based
book, which were found in the study period, from respective
study in our country shows inconsistency in death trend. So
wards then sampling frame was prepared in both hospitals.
the need of further study is unquestionable to identify trend
Then after, 119 cases were proportionally allotted for each
and factors affecting maternal death. Particularly institutions
hospital. After identifying the cases included in the sample the
based study is important to observe the trend, and associated
time of admission was identified for each selected cases
factors of maternal death.
[21,22]. For each case, four controls were selected, which were
admitted immediately preceding or following a case. Selected
Methods 119 maternal death and 476 controls charts were reviewed.
Maternal death charts which were included in the sample but
Study area and period missed charts were replaced by random selection from charts
which were not included in the sample. When maternal death
The study was conducted in Mizan-Tepi university teaching charts were replaced the controls were also replaced together
& Bonga general hospital. Which are located southwest, with case [23-26].
Ethiopia. The hospitals provide care for south-western Ethiopia
with a catchment population of about 5 million. Internal Data collection instrument was adapted from Maternal
medicine, surgery, obstetrics and gynecology and pediatrics Death Surveillance and Response Technical Guideline of
are the major departments. Institution based case control Ethiopia [27]. The checklist consists of socio-demographic
study design was used from 2011 – 2015 charts. data, obstetric and delivery history, presence of co morbidities,
cause of death, antenatal and intranatal risks and presence of
The source Population of the study was all charts of mothers complications. Three midwives were recruited and trained for
who visited Mizan-Tepi university teaching & Bonga general two days. The training was cover about the contents of the
hospital for maternal health service utilization. Whereas the tool, ethical considerations and way of extraction of necessary
Study Population for case was all charts of mothers who were information from chart. Two public health supervisors were
passed away during pregnancy, delivery and 42 days after monitored and followed data collection while the principal
delivery in Mizan-Tepi university teaching & Bonga general investigator supervised the overall data collection process.
hospital between 2011 to 2015, cases was ascertained based
on the information of chart. If death was reported on the To assure the quality of data, data collectors were trained
chart, it has been taken as a case. While, all charts of mothers until they became well familiar with the instrument. Every day
who visited Mizan-Tepi university teaching & Bonga general filled checklist was reviewed and checked for completeness
hospital for maternal health service utilization from 2011 to and relevance by supervisors and principal investigator.
2015 were Controls. After data collection, each filled checklist was given a unique
The sample population was randomly selected cards of code by the principal investigator. Then the data was entered
cases and controls during the study period. Cases that fulfill in to epi-info version 3.5.1 after that exported to SPSS version
the standard definitions of maternal mortality given by ICD – 21 for analysis. Frequencies were used to check for entry
10 and controls which came for maternal health service errors, missed values and outliers. Any identified error was
utilization were included. But cases that were registered on corrected with the revision of the original data using the code
the log book but whose charts’ were missed and Charts that numbers.
Multiple imputations were considered if there is greater or seven (39.8%) of the women were developed labor
equal to 0.001% of missing values. The maximum number of abnormality. However, 245 (41.8%) of women were delivered
missing values allowed for multiple imputations was 30%. If by spontaneous vaginal delivery (SVD). More than half, 341
there was more than 30% missing values the chart was (57.3%) of the births were attended by midwifery. From
replaced by random selection from available charts. Missed women who had 3 – 4 gravidity, 3 – 4 parity, and women who
charts and charts which don’t include the final assessment of don’t have ANC were 26%, 27%, and 63% were died
admission and status during discharge were replaced by respectively (Table1).
random selection from cases which were not included in
About, 37% and 35% of women were died from women who
sample together with controls.
had length of labour greater than 24 hrs more and who had
Bivariate analysis was used to determine the association labor abnormality respectively. From all women who undergo
between different factors and the outcome variable. Variables destructive delivery procedures, half of them were died (Table
that have p value less than or equal to 0.05 was entered into 1). Pertaining to mode of delivery, 197(33.6%) of women were
multivariate binary logistic regression to identify independent delivered by C/S. while, 245(41.8%) were delivered by
predictors of maternal mortality. Confidence interval of 95% spontaneous vaginal delivery (SVD) (Figure 2).
was used to see the precision of the study and the level of
significance was taken at p value ≤ 0.05. The adjusted odds
ratio with the 95% CI was reported. Graphical presentation
such as tables, line graphs and pie charts was used to present
the result findings of the study.
Maternal mortality trend was done using the total number
of cases occurred in the study period. Trend was shown using
MMRatio. The total MMRatio in five year and each year MMR
was calculated using the following formula:
����� ������ �� �������� ����ℎ �� �ℎ� ����� ������
��� = ����� ������ �� ���� ����ℎ� �� �ℎ� ����� ������
× 100, 000
Figure 1 Shows age of women delivered from 2011 -2015 at
Prior to data collection, ethical clearance was obtained from Mizan–Tepi university teaching and Bonga hospitals 2016.
Research and Ethics committee of the College of Health
sciences, Mizan-Tepi University. Written permission letter was
also received from Mizan-Tepi university teaching & Bonga
general hospital CEO. In order to establish anonymous linkage
only the codes, not the names of the participant from the
chart, was registered on the questionnaire.
Result
A total of 119 cases (dead women) and 476 controls
(survived women) were included in the study. Variables such
as, ethnicity, educational status, marital status, occupation,
Figure 2 Shows mode of delivery among women delivered
and income were incomplete in 99% of charts: As a result, they
from 2011 -2015 in Mizan Tepi university teaching and
were excluded from analysis.
Bonga hospitals, 2016.
Age distribution
Majority, 397 (66.7%) of women in this study were in the Obstetric complications
age group of 20-34 years. While the least age group was age
greater or equal to 35 years old. More than 22% of females Thirty two (94.6%) of women had co morbidity, of those
died from the age group of 20 – 34 years old (Figure 1). anemia and HIV/AIDs accounts 15 (46.9%) each. Whereas, 25
(4.2%) were developed abnormal puerperium. Of which, PPH
was the most common that accounts 17 (68%) (Table 2).
Obstetric and delivery history
Taking into account, risk during antenatal period 68(11.4%)
Regarding to obstetric and delivery history around 393 of the women’s were presented with different antenatal risks
(66.1%) were gravid 1-2 and 480 (80.7%) were in parity 0-2. (placenta previa, multiple gestation, & abruption placenta). Of
Majority, 413 (69.4%) were attending ANC. of those 187 those, more than half of them were died. From total women
(45.2%) were attended 4 times and more. From the total
women, 227 (38.2%) were come to the hospitals through
referral due to different complication. Two hundred thirty
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Health Science Journal 2016
ISSN 1791-809X Vol.10 No.5:16
who had abnormal puerperium only 20% of them were Mode of delivery
survived (Table 2).
SVD 218 (89%) 27 (11%)
Table 1 Shows obstetric and delivery history among women Vaginal assisted (instrumental,
who gave birth from 2011 -2015 in Mizan –Tepi university episo..) 126 (89.4%) 15 (10.6%)
teaching and Bonga hospitals 2016. C/S 126 (64%) 71 (36%)
Table 3 Bivariate and multivariate logistic regression analysis of factors associated with maternal mortality in Mizan- Tepi
university teaching and Bonga hospitals town (n=595), May 2016.
Maternal status
Attending ANC
Yes 360 53 1 1
Length of labor
Labor abnormality
No 322 36 1 1
No 397 21 1 1
Hemorrhage
No 471 95 1 1
Uterine rupture
No 465 66 1 1
Abortion
No 473 107 1 1
Presence of co-morbidity
No 455 108 1 1
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ISSN 1791-809X Vol.10 No.5:16
Anemia
No 469 111 1 1
Abnormal puerperium
No 471 99 1 1
Antenatal risks
No 435 92 1 1
Birth attendant
MSc in surgery & obs. 109 17 1.7 (0.89, 3.17) 0.23 (0.05,1.09)
Midwives 312 29 1 1
Mode of delivery
SVD 218 27 1 1
Vaginal assisted delivery (induc,epi) 126 15 0.96 (0.49, 1.87) 0.57 (0.19,1.69)
There is strong association between attending ANC and death than who delivered spontaneous vaginal delivery (SVD)
maternal mortality. That is women who were not attending (AOR=10.9, 95% CI 2.13, 56.2) (Table 3).
ANC were 2.4 times more at risk for death than those who
attend (AOR=2.4, 95% CI 1.19-4.83). And those who develop
prolonged labor or whose labor greater than 24hrs were 4
Discussion
times more at risk for death than labor less than 24 hrs Maternal death in our country has a decreasing trend as
(AOR=4, 95% CI. 1.86-8.74). depicted by different reports and reviews. As, 2013 combined
Similarly presences of obstetric complications were reports of WHOM, UNICEF, the World Bank and UNFPD,
significantly associated with maternal mortality. Women who Ethiopia shows a decreasing pattern of maternal death.
develop different obstetric complications were 7.2 times more However, the general MMR in these hospitals was 960/105. It
at risk for death compared to counterparts (AOR=7.2, 95% CI has a fluctuation pattern from 764 to 1265/105. It was highest
3.08, 16.72). In addition, uterine rupture was other in 2013 with 1265/105 and lowest in 2015 with 764/105 than
determinant for maternal mortality. Women who develop other study periods in the study period. But, Review of
uterine rupture were 11.4 times more at risk when compared different community and hospital based studies by Ahmed
to their counter parts (AOR=11.4 95% CI 4.27, 30.41). Abdela shows a decreasing pattern of maternal death. Review
made in jimma hospital before 15 years back and in Ambo
There is also statistically significant association between hospital before 5 years back shows fluctuation of MMR from
abnormal puerperium and maternal mortality. That is those 671-3986 per 105 but it was higher in general than the current
who had abnormal puerperium were 10.9 times more at risk of our finding. Review of maternal death from 2002–2006 in
for death than those who had not developed (AOR=10.9, 95% JUSH also shows a decreasing pattern with total MMR of
CI 1.96,59.97). Again, those who had antenatal risks ( placenta 888/105 [7,18,28–30]. Decrease in occurrences of death from
previa, Abruption placenta, Previous C/S & Multiple gestation) previous years in these hospitals particularly after 2010 might
were 3.8 times more likely to die than their complements be because of increasing awareness of community about
(AOR= 3.8, 95% CI 1.64, 8.61). institutional delivery, organizational and policy factors.
Strong association was also found between mode of Organizational factors might be service expansion and human
delivery and maternal mortality. That is women who delivered power expansion, increasing availability and accessibility of
with destructive delivery were 10.9 times more at risk for health institution. The other factor might be after 2010 in our
country there was country wide mobilization to decrease
death of mother with slogan of “no mother should die while 11.4 times more at risk to die than their counter parts (AOR=
she gave birth.” In the other extreme it might be because of 11.4 95% CI 4.27, 30.41). In Senegal women who had uterine
under reporting of death due to fear of bad criticism and rupture were 28 times more likely to die than their counter
captivity of health professionals and health facility. These parts AOR=28.07 95% CI (11.34 69.51) [31,32]. The reason
things might be the reason. might be uterine rupture is the major source of concealed and
revealed hemorrhage that finally leads to death.
Factors affecting maternal death Those who had ante or intranatal risks (placenta previa,
The study revealed that maternal death was significantly Abruption placenta, Previous C/S & Multiple gestation) were
different among women who did not attending ANC and those 3.8 times more likely to die when compared to their
who attend ANC. Women who did not attend ANC were 2.4 counterparts (AOR= 3.8, 95% CI 1.64,8.61). These risks are the
times more at risk for death than those who attend (AOR = 2.4, sources of uterine rupture and hemorrhage which are the
95%CI 1.19 -4.83). This finding was in line with study done in most prominent cause of death.
china and Kenya , those who have not attended ANC were
more likely at risk of death (AOR, 22.3; 95% CI, 4.3-116.0) and Conclusion and Recommendation
AOR 4.1, 95% CI 1.6-10.4) respectively. Attending ANC as a
protective factor from death is observed in public hospital of The number of maternal death has a fluctuation pattern
Tigray [AOR= 0.26, 95% CI (0.12-0.57)]. Similarly study done in over the year. Women who do not have ANC follow up;
Ambo shows that maternal death were higher among women presence of obstetric complications, women who had ante or
who did not attend ANC (11% had ANC Vs 38% had no ANC) intra natal risks and women who had prolonged labour are
[14,18,20,25]. In ante natal care there are many things more at risk for maternal death. Based on the findings from
performed like provisions of iron, folate and other health this study the following recommendations are made. Health
promotive and preventive activities. In addition ANC professionals including HEWs should have to work in
attendance makes the women to prepare for birth and for strengthen approach to improve awareness of the community
complication readiness. These activities prevent death of about pregnancy, its complication and co morbidities, and ANC
mothers. That is why not attending ANC is a risk factor or uptake. Academicians and researchers should dig out
attending ANC become a protective factor. alternative solution for maternal death.
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Health Science Journal 2016
ISSN 1791-809X Vol.10 No.5:16
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