4/8/2020 Hemostasis - NCA- CLS Q's Flashcards | Quizlet

Hemostasis - NCA- CLS Q's

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Created by

Cesar_Sarmiento9

Terms in this set (29)

Oral Anticoagulation Be neutralized by protamine sulfate,

therapy with coumadin Coumadin interferes with the synthesis of
may do all of the factors 2,7,9,10 by consuming vitamin K.
following except? Protamine sulfates may be used to
A: Prolong the Pro- counteract heparin but not coumadin
thrombin time
B:Act in the peripheral
blood to decrease factor
activity
C:Prolong the APTT
D:be neutralized by
protamine sulfate

Blood collected for 3.2% sodium citrate with a 9:1 Blood to

anticoagulation therapy anticoagulant ratio
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should be collected in?

A: 3.5% sodium citrate
with a 9:1 Blood to
anticoagulant ratio
B: 3.2% sodium citrate
with a 9:1 Blood to
anticoagulant ratio
C:4% sodium citrate with
a 8:1 Blood to
anticoagulant ratio
D: 3.8% sodium citrate
with a 10:1 Blood to
anticoagulant ratio

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All of the following Decreased prothrombin.

conditions may cause an
increased thrombin time
except?
A: Hypofibrinogenemia
B: Increased fibrin
degradation products
C: Heparin Therapy
D: decreased
prothrombin

What pathway does the Intrinsic pathway

APTT screen for?

The APTT is a screening XIII, the APTT is not sensitive for

test for all coagulation deficiencies in factor 13,
factors in the intrinsic
pathway except for?
A: VIII
B:IX
C:XI
D:XIII

The coagulation factor VIII, factor 8 is severely decreased in

that is decreased in hemophilia A, factor IX(9) is decreased in
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hemophilia A is? hemophilia B.

A: IX
B: X:
C:VIII
D:VII

Thawing of platelet poor 35-38 C, the preffered temperature is 37

plasma that has been degrees C.
stored at -40 degrees C
for anticoagulation
studies should be
performed at what
temperature?

A: 0-4 C
B:4-8 C
C: 10-20 C
D: 35-38 C

Which two plasma V and VIII, factors 5 and 8 may lose as

coagulation factors are much as 50% activity at room temperature
least stable in vitro? after 8 hours.
A: VII and IX
B:V and VIII
C: XI and XII
D:I and III

A clinical laboratory Request a new sample, Samples for an

technician notes that a APTT should be help at room temp for no
specimen for an APTT longer than four hours.
has been stored at room
temperature for five
hours prior to testing,
The CLT should?
A: Perform the APTT
report the results
B:Perform the APTT and
report the results, noting
the delay in processing.
C: Dilute the sample 1:1
with a buffered saline to
correct the pH and
perform the APTT
D: Request a new
sample.

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Disseminated Activation of both intrinsic and extrinsic

Intravascular systems and a consumption of platelets.
Coagulation (DIC) may
display which of the
following coagulation
problems?
A: An activation of the
extrinsic system and a
prolonged bleeding time
B: Activation of the
intrinsic system and a
decreased factor VIII
C: Activation of both
intrinsic and extrinsic
systems and a
consumption of
platelets.
D: a prolonged bleeding
time and a reduction of
factor VIII

A new lot os controls for 11.1 sec

prothrombin has a mean
of 12.2 with and SD of .4.
Which of the following
results would not be
acceptable?
A: 11.1 sec
B:11.5 sec
C: 12.3 sec
D: 12.6 sec

An upward trend was Loss of precision. Shifts, trends, and

observed over a six day increased scatter all indicate a loss of
period in a quality precision.
control for a
prothrombin time
procedure performed
on a photo optical
instrument. This
observation indicates a ?
A: decreased in the
standard deviation and
thus a change in the
reference range of the
procedure
B: Loss of precision
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C: Decreased coefficient
of variation
D: loss of accuracy but
not precision

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Plasma is diluted in a Influence of inhibitors. Dilution of plasma

fibrinogen determination in this procedure produces an excess of
to decrease the ? thrombin. Thus nullifying the effect of
A: amount of thrombin inhibitors and making fibrinogen the rate
necessary limiting factor.
B: Influence of inhibitors.
C: amount of calcium
needed
D: Effect of deficiencies
in the other coagulation
factors

Up to what % HCT are 55%,

regular sodium citrate
tubes effective ?

A: 45%
B:65%
C:55%
D: 75%

What should the order of BLUE, GREEN, EDTA.

draw be when drawing a
hematology tube( EDTA),
Chemistry tube(TIGER
GREEN) and a
hemostasis tube (BLUE)?

A specimen for Shortened due to platelet neutralization of

determination of APTT heparin, factor VIII is stable for over 5
for monitoring heparin hours , but platelet release of heparin
therapy is collected in neutralizing proteins will shorten the APTT
sodium citrate at 9:30 within 1 hour of collection.
and allowed to remain at
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room temperature until it

is brought to the
laboratory at 2:30, what
effect will the storage
have on the results?

A: Shortened due to the

increased glass
activation
B: Prolonged due to the
deterioration of factor
VIII
C: Shortened due to
platelet neutralization of
heparin
D: No effect

A patient with anatomic Test for factor XIII deficiency.

bleeding and poor
wound healing has the
following hemostasis
results:
APTT- Normal
PT- Normal
Platelet count - 195,000
Platelet aggregation -
Normal

What is the logical next

hemostasis test?

A: Lupus anticoagulant
screen
B: Test for a single factor
inhibitor
C: test for factor XII
deficiency
D: test for factor XIII
deficiency

The coagulation factor X(10), Patients with factor X deficiency

deficiency that can have prolonged APTT and PT assays.
display both an
abnormal PT and APTT is
factor?

A: VIII
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B: IX
C:X
D: XI

A patient has an Heparin. Reptilase time is unaffected by

abnormal thrombin time heparin.
and a normal reptilase
time, Which of the
following can produce
this result?
A: Afibrinogenemia
B: Elevated fibrin
degradation products
C: heparin:
D: Coumadin

A patient has a normal PT Mix 1 part patient plasma and 1 part norma
and a prolonged APTT. plasma and repeat the APTT only, If the
To distinguish whether original prolonged test is corrected a
the prolonged APTT is factor deficiency is likely, If mixing yields
caused by a factor prolonged results then an inhibitor is
deficiency or an inhibitor, suspected.
the MLS should?
A: Mix 1 part patient
plasma and 1 part norma
plasma and repeat both
the PT and PTT
B:Mix 1 part patient
plasma and 1 part norma
plasma and repeat the
APTT only
C: Perform a factor X
assay: if prolonged a
factor X deficiency is
indicated
D: perform a plasma
Thrombin time test

The most common activated protein C resistance,

frequent hereditary
condition predisposing
to venous thrombosis is?
A: dysfibrigenemia
B: Protein S deficiency
C: Protein Z deficiency

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D: activated protein C
resistance

An unexpectedly small Antithrombin. Antithrombin inhibits

anticoagulant response thrombin and other activated serine
to heparin therapy may proteases and heparin serves as a
be caused by decreased cofactor for the reaction.
levels of?
A: Antithrombin
B: Platelet factor 4
C: Factor XIII
D: Thromboxane

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Unfractionated Heparin Antithrombin -III, In its natural state

must have which of the Antithrombin-3 is an inhibitor and in the
following coagulation presence of heparin it becomes a very
inhibitors present in potent inhibitor. Therefore heparin therapy
normal amounts in order depends on the levels of AT-3
to properly
anticoagulate a patient?
A: Protein S
B: Protein C
C: Antithrombin III
D: Alpha 2- antiplasmin

An 18 year old female Platelet aggregation studies. These results

was scheduled to have are indicative of a qualitative Von
her wisdom teeth willebrand disease .
removed. Becuase the
patient had a history to
nosebleeds, heavy
menstrual periods, and
easy bruisability, the
surgeon requests a full
coag screen. Results are:
PT: normal
APTT: Prolonged
Platelets: 300,000

What additional
procedure should be

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performed?

A: Factor VII assay.

B: Vitamin K assay
C: Platelet aggregation
studies
D: Thrombin clotting
time.

The formation of D- cross-linked fibrin

Dimer is the by- product
of the effect of plasmin
on?
A: Fibrin degradation
products
B: cross-linked fibrin
C: Fibrinogen
D: plasminogen

What reagent is added Firefly luciferase

to the conventional
aggregometry, to test
platelets for release as
well as aggregation?
A: ATP
B: Firefly luciferase
C:Riscocetin
D: ADP

In the performance of Patient Poor Plasma (PPP)

platelet aggregometry
on patient results, the
instrument should be set
to 100% transmittance
using :

A: Patient Poor plasma

(PPP)
B: Patient Rich plasma
(PRP)
C: Control Patient poor
plasma
D:Control patient rich
plasma

Which of the following Prothrombin deficiency

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conditions can cause a

prolonged thrombin
clotting time?
A: Prothrombin
deficiency
B: Coumadin therapy
C:Antithrombin
deficiency
D:Hypofibrinogenemia

The most common Liver disease. The liver is responsible for

generalized hemostatic the production of nearly all of the plasma
disorder is? coagulation system proteins.
A: Vitamin K deficiency
B: Liver disease
C:Hemophilia
D: Von Willebrand's
disease

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