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Meta Abstract of Sesd4 Lect2

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Fuel storage, lipid metabolism and glycogen

metabolism
The body require a continuous supply of
glucose; initially this requirement is met by
.storing glucose as glycogen
Glycogen is highly branched polymer of
glucose residues linked together by glycosidic
.bonds.it store in liver and skeletal muscle
The glycogen is degraded in skeletal muscle in
response to exercise and in the liver in
.response to fasting or stress condition
The metabolism is highly regulated by
.allosteric control and covalent modification
Any defect or deficiency of one of the enzyme
involve in its metabolism will cause a clinical
problem (glycogen storage disease) which
result in tissue damage, fasting hypoglycemia,
.poor exercise tolerance
:Lipid metabolism
.Lipids are generally hydrophobic compound
In addition, they are different types of it
including fatty acid derivatives, hydroxyl-
.methyl-glutaric acid derivatives and vitamin
The major dietary and storage lipid is
triacyglyceroles, which store in adipose tissue,
and it hydrolyzed and give energy in prolong
aerobic exercise, stress situations such as
.starvation and during pregnancy
On hydrolysis of TG, it give glycerol and fatty
acids this is a complex process that requires
.bile salts and lipase enzyme
.The metabolism of glycerol occur in the liver
TG are hydrolyzed when the body subjected
to stress condition, by enzyme hormone
sensitive lipase to release FA and glycerol that
diffuse from the tissue (lipolysis)
The condition of oxidation of FA to release
energy is called beta-oxidation and it is occurs
.in the mitochondria
Acetyl Co-A is produce by the catabolism of
FA also from (sugars, alcohol and certain
amino acids) can be oxidized via stage 3 of
catabolism.it is also important in lipid
biosynthesis
The liver and some of adipose tissue are the
.site of lipogenesis
The energy produce by lipid oxidation much
more than the energy produce by protein and
.carbohydrates

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