Ledger 2007
Ledger 2007
Ledger 2007
ORIGINAL ARTICLE
Abstract
This study aimed to investigate the long-term effects of group music therapy on agitation manifested by nursing home
residents with Alzheimer’s disease. A non-randomised experimental design was employed with one group receiving weekly
music therapy (n ¼ 26) and another group receiving standard nursing home care (n ¼ 19). Agitation levels were measured
five times over one year using the Cohen-Mansfield Agitation Inventory (Cohen-Mansfield, J. (1989). Agitation in the
elderly. In N. Billig & P. V. Rabins (Eds.), Issues in geriatric psychiatry (pp. 101–113). Basel, Switzerland: Karger). Although
music therapy participants showed short-term reductions in agitation, there were no significant differences between the
groups in the range, frequency, and severity of agitated behaviours manifested over time. Multiple measures of treatment
efficacy are necessary to better understand the long-term effects music therapy programs have on this population.
Introduction
Agitation leads to severe disturbances in the quality (Mahoney, Volicer, & Hurley, 2000; Opie,
of life of people with Alzheimer’s disease and Rosewarne, & O’Connor, 1999).
their carers (Cohen-Manfield, 1986, 1999; Foli & Music therapy is one intervention which aims to
Shah, 2000; Marin et al., 1997). Estimates of the create secure, stimulating environments, to meet
prevalence of agitation vary depending on the social and emotional needs, and to reduce agitation
terminology, assessment tool, population, and displayed by people with Alzheimer’s disease and
setting employed (Colenda, 1995; Tractenberg, other types of dementia (Brotons, Koger, &
Weiner, & Thal, 2002), ranging from 24% to 98% Pickett-Cooper, 1997; Nugent, 2002). Short-term
of people diagnosed with dementia (Gruber- reductions in agitated behaviour have been reported
Baldini, Boustani, Sloane, & Zimmerman, in music therapy case studies and research under-
2004; Sourial, McCusker, Cole, & Abrahamowicz, taken with people with dementia (Brotons &
2001). Pickett-Cooper, 1996; Fitzgerald-Cloutier, 1993;
People with Alzheimer’s disease show a range of Groene, 1993; Nugent, 2000; Ridder, 2003;
agitated behaviours, including repetitive acts, behav- Suzuki et al., 2004; Thomas, Heitman, &
iours inappropriate to social norms, and aggressive Alexander, 1997). Explanations for the success of
behaviours towards self or others (Cohen-Mansfield music therapy in reducing agitation include the
& Martin, 1999). The progression of a person’s effects of music on attention (Baker, 2002; Ridder,
agitated behaviours is difficult to predict. Although 2003) and quality of life components (Ruud, 1998).
agitated behaviours are likely to persist and increase Familiar music may serve to regulate a person’s
in severity over time, they do not worsen system- arousal to a moderate level (Baker, 2002; Ridder,
atically (Eustace et al., 2002; Haupt, Kurz, & Jänner, 2003), or redirect a person’s attention from
2000; Levy et al., 1996). Instead, agitated behav- misleading or confusing stimuli (Gerdner, 1999).
iours are more episodic in nature, fluctuating over A person with dementia may then be more able to
time. Possible causes of agitation include interpret his or her environment and any fear
under-stimulating or demanding environments, or or agitation may be lessened. Success in singing,
a person’s reduced ability to communicate and have playing instruments, moving to music, or sharing
his/her needs met (Cohen-Mansfield & Martin, memories or views related to music, may also meet
1999). Interventions that address these possible a person’s unmet needs for self-expression, achieve-
causes of agitation are therefore imperative ment, and meaning in life (Clair & Bernstein, 1990;
Correspondence: Alison Ledger, Clinical Lecturer in Music Therapy, School of Music, University of Queensland,
Australia 4072. Tel: þ61 7 3365 4146. Fax: þ61 7 3365 4488. E-mail: a.ledger@uq.edu.au
ISSN 1360-7863 print/ISSN 1364-6915 online/07/030330–338 ß 2007 Taylor & Francis
DOI: 10.1080/13607860600963406
Long-term effects of music therapy on agitation 331
Pollack & Namazi, 1992; Prickett & Moore, 1991; The chosen nursing homes were either community,
Ridder, 2003; Rio, 2002; Short, 1995; church, or privately operated and offered a mixture
Tomaino, 2000). Music therapy groups may espe- of high and low nursing care. Each nursing home
cially promote feelings of belonging among partici- provided residents with access to activities such as
pants with dementia (Ebberts, 1994; Pollack & outings, concerts, arts and crafts, games, cooking,
Namazi, 1992; Rio, 2002). As agitation is viewed or gardening.
as an expression of feelings of despair, frustration,
boredom, or loneliness (Cohen-Mansfield & Martin, Participants
1999), music therapy may reduce agitated
behaviour by lessening such feelings (Ashida, 2000; A sample of 60 participants (30 experimental and
Bright, 1997; Groene, 1993; Pollack & Namazi, 30 control) was required to detect significant
1992; Rio, 2002; Short, 1995). differences between the experimental and control
Although research indicates that music is an groups (p50.05, power of 80%). Sixty-eight were
effective intervention for reducing agitated behav- initially recruited to allow for attrition. Inclusion
iours, there are weaknesses and limitations to criteria comprised:
existing studies, including small sample sizes and (a) Primary diagnosis of Alzheimer’s type dementia.
within-participants designs (Brotons et al., 1997; (b) Stage 4, 5, or 6 on the Global Deterioration
Koger, Chapin, & Brotons, 1999; Lou, 2001; Scale (GDS) for assessment of primary degen-
Nugent, 2002; Sheratt, Thornton, & Hatton, erative dementia (Reisberg, Ferris, De Leon, &
2004b; Ridder, 2005; Vink, Birks, Bruinsma, & Crook, 1982).
Scholten, 2003). Furthermore, no studies have (c) Cognitive impairment evident upon
specifically tested whether music therapy can have Mini-Mental State Examination (MMSE523.
long-term influences on the agitation levels of people Folstein, Folstein, & McHugh, 1975) or Mental
with dementia (Ledger & Baker, 2005). This study Status Questionnaire administration (MSQ > 2
aimed to address the limitations of earlier research, errors; Kahn, Goldfarb, Pollack, & Peck, 1960).
by employing a large sample size and a control
group, and investigating the possibility that music Due to the high prevalence of agitation among
therapy has long-term effects on people with people with moderate to severe dementia
Alzheimer’s disease. The study specifically tested (Sourial et al., 2001), presence of agitation was not
whether music therapy participants with Alzheimer’s specified as an inclusion criterion. Nursing home
disease manifested fewer, less frequent, or less severe residents were to be excluded if they were in poor
types of agitated behaviours over time than people health (indicating that they were unlikely to com-
who were not receiving music therapy. plete the year-long study). Although variability in
demographic characteristics, psychotropic medica-
tion use, levels of pain, depression and fatigue,
quality of staffing, quality of relationships with
Method
others, and past experiences of stress were consid-
Design ered likely to influence participants’ agitation levels,
The study employed a longitudinal repeated mea- it was expected that these variables would be
sures design with an experimental and control group. balanced between the experimental and control
Participants were studied over a one-year period, this participants. Although these variables were not
being appropriate to detect agitation changes in the controlled, data pertaining to these variables was
participants (Levy et al., 1996; Weiner et al., 1998). collected and the influence of these variables
Experimental group participants were offered weekly was explored.
group music therapy treatment, while control group Participants were allocated to either the experi-
participants received their usual nursing and therapy mental or control group based on their current place
care. This design was approved by one of the human of residence (convenience sample). The five nursing
ethics committees of the University of Queensland in homes assigned to the experimental condition were
accordance with the National Health and Medical all within Brisbane, as this condition required weekly
Research Council’s guidelines. visits from a registered music therapist. Consent for
68 eligible participants was obtained, however
eight did not participate in the study because:
Settings
(a) five participants in the experimental group chose
Thirteen nursing homes in Queensland (12) and not to participate in music therapy; (b) one partici-
Victoria (1) participated in the study, two of which pant in the control group moved to a different nursing
already offered music therapy services to its nursing home and subsequently began receiving music
home residents. Nursing homes within organizations therapy; (c) one participant died before receiving
known to show interest in music therapy services the first session of music therapy; (d) one participant
were selected based on location (i.e. within reason- became distressed in music therapy and the service
able travelling distance from research personnel). discontinued after she received five sessions.
332 A. J. Ledger & F. A. Baker
Table I. Characteristics of participants.
Age 71–75 3 0
76–80 4 3
81–85 6 7
86–90 9 6
91–95 3 2
96–100 1 1
Gender Male 4 1
Female 22 18
GDS stage 4 4 2
5 14 10
6 8 7
Level of cognitive impairment Mild 4 1
Moderate 7 6
Severe 15 10
Not recorded 0 2
Medications Acetylcholinesterase inhibitors 3 5
Antipsychotic 11 4
Antidepressant 7 8
Antianxiety 3 2
Narcotic 1 1
Social Support Once/week or more 21 11
Less than once/week 5 7
Not recorded 0 1
yExperimental n ¼ 26; Control n ¼ 19; Total N ¼ 45
Of the 60 participants who began the study, only brain injury, cerebral aneurysm, and epilepsy.
45 participants completed all five testing phases. Twenty-two experimental and seventeen control
One participant from the experimental group left the group participants were assessed as in stages five or
study when she moved away and ceased receiving six (moderate or moderately severe Alzheimer’s
music therapy treatment. A further 14 participants disease) on the GDS and the remainder
(three from the experimental group and eleven from (four experimental, two control) were assessed as
the control group) passed away in the course of the in stage four (mild Alzheimer’s disease) of the GDS.
year’s research. Due to the highly individual, Most participants (experimental n ¼ 22, control
fluctuating, and unpredictable nature of agitation n ¼ 16) showed moderate to severe cognitive impair-
(Levy et al., 1996), only the data from those ment on either the MMSE or MSQ. A greater
participants who completed the study were included proportion of the experimental participants (42%
in the analysis. of experimental participants versus 21% of control
Characteristics of the 45 participants (26 experi- participants) had been prescribed antipsychotic
mental, 19 control) who completed the study are medication, which may have contributed to
displayed in Table I. The participants ranged from lower baseline agitation levels (Weiner &
71 to 96 years of age (experimental group Schneider, 2003).
M ¼ 84.81, SD ¼ 6.62; control group M ¼ 85.63,
SD ¼ 5.22) and most were female. Three partici- Intervention
pants in the experimental group and none in the
control group were from non-English speaking Participants in the experimental group participated
backgrounds. About three quarters of the partici- in weekly sessions (30–45 minutes) of group music
pants (21 experimental, 12 control) had contact with therapy for at least 42 weeks within a year. Research
family or friends at least once per week. None of the suggests that the effects of music therapy on
participants had received music therapy treatment agitation can be noted with one-to three-weekly
prior to the commencement of the research. sessions (Brotons & Pickett-Cooper, 1996; Clair &
Experimental group participants who completed Bernstein, 1990; Ebberts, 1994; Jennings & Vance,
the study attended a mean number of 44.65 3.1 2002; Olderog Millard & Smith, 1989;
music therapy group sessions during the year of Sambandham & Schirm, 1995; Suzuki et al.,
research. 2004). Sessions were held at consistent times in
Some participants had neurological or psychiatric accordance with residents’ existing routines–three of
disorders alongside dementia of the Alzheimer’s type the groups took place in the morning and two
(experimental n ¼ 9, control n ¼ 6), such as depres- of the groups took place in the mid afternoon.
sion, schizophrenia, Parkinson’s Disease, stroke, Groups consisted of two to ten research participants
Long-term effects of music therapy on agitation 333
at any one time. Group music therapy was preferred (Finkel, Lyons, & Anderson, 1992; Miller,
over individual therapy as this intervention is Snowdon, & Vaughan, 1995; Shah, Evans, &
reported in music therapy literature as effective in Parkash, 1998; Sourial et al., 2001; Snowdon,
addressing people’s unmet needs for interaction and Miller, & Vaughn, 1996; Weiner et al., 2000).
belonging (Christie, 1995; Ebberts, 1994; Pollack & As research personnel (the first author and the
Namazi, 1992; Rio, 2002; Silber & Hes, 1995) and research assistant) were only present during music
reducing agitation during and immediately post- therapy sessions, they interviewed nursing staff to
session (Lesta & Petocz, 2006). Participants who obtain more comprehensive CMAI assessments for
resided at nursing homes allocated to the control the research participants. Research personnel
condition received their usual nursing and therapy recorded nurses’ responses on a tick-sheet. Due to
care over the one-year period. the high turnover of nursing staff in the participating
Four of the music therapy groups were conducted nursing homes, it was not always possible to inter-
by the first author (a qualified music therapist) and view the same staff at each of the five time points.
one group was conducted by a research assistant As the goal of the CMAI is ‘‘to achieve the most
(also a qualified music therapist). The musical accurate reflection of the frequency at which these
content of the music therapy sessions was decided behaviours occurred’’ (Cohen-Mansfield, 1991,
by the treating music therapist and varied depending p.4), research personnel interviewed the nurse on
on participants’ assessed needs, abilities, back- duty who had the most frequent contact with
grounds, and musical preferences. Each group research participants during the previous two
had a similar overall structure (greetings-main weeks. An average of three nursing staff were
section-song requests-farewells) and sessions interviewed at each nursing home over the one-year
included techniques that aim to promote period.
self-expression, control, mastery, belonging, and
purpose (Brotons & Pickett-Cooper, 1996; Clair & Analysis
Bernstein, 1990; Ebberts, 1994; Groene, Zapchenk,
Total CMAI scores and subtype scores for each
Marble, & Kantar, 1998; Hanson, Gfeller,
participant at each of the five time points were
Woodworth, Swanson, & Garand, 1996; Prickett &
calculated by assigning values to the frequency
Moore, 1991; Rio, 2002). Participants joined in
ratings for each behaviour (‘‘Never’’ ¼ 0 through to
sessions through listening to music played by the
‘‘Several times an hour’’ ¼ 6). Means and
therapist, choosing or requesting favourite songs,
standard deviations of the experimental and control
guessing song-titles from melodic/lyric clues, sing-
groups’ total and subtype CMAI scores were
ing, playing instruments, moving to music, and
then determined for each time point. A repeated
discussing feelings and memories.
measures multivariate analysis of variance
was employed to test for differences between the
Measures experimental and control groups in the range,
Participants’ agitation levels were assessed using the frequency and severity of agitated behaviours
CMAI-long form (Cohen-Mansfield, Marx, manifested over time.
Rosenthal, 1989) prior to the commencement of the
experimental or control period, and then at three, six, Therapist’s log
nine, and twelve months following commencement of In addition to the CMAI measures, the two qualified
the experimental or control period. The CMAI music therapists conducting the clinical interven-
measures the frequency of 29 agitated behaviours in tions kept a log of observed changes in participants’
the two weeks prior to the CMAI assessment. CMAI agitation from pre to post session using the CMAI
scores can be summarized according to four behav- behaviours as descriptors. Only noticeable changes
iour subtypes – verbal non-aggressive behaviour (e.g., were recorded.
repeated unwarranted requests for attention such as
calling out), verbal aggressive behaviour (e.g., cur-
sing, threatening, or insulting language, verbal sexual Results
advances), physical non-aggressive behaviour
Range and frequency of behaviours
(e.g., repetitive behaviours such as wandering,
tapping, or repeated attempts to undress inappropri- The range and frequency of agitated behaviours are
ately), and physical aggressive behaviour (e.g., reflected in the participants’ mean total CMAI
destroying objects or property, throwing objects, scores, graphed in Figure 1 for the five data
grabbing, pushing people) (Cohen-Mansfield, 1999; collection points. Initial CMAI scores were signifi-
Cohen-Mansfield & Martin, 1999). CMAI scores cantly higher (t ¼ 2.17, p50.05) for the control
correlate significantly with scores on other measures group and both groups showed large standard
of agitation, and demonstrate high internal deviations before the commencement of the
consistency reliability (r 0.82), test-retest reliability music therapy intervention (control group: CMAI
(0.97), and high inter-rater reliability (r ¼ 0.8) M ¼ 39.05, SD ¼ 22.15; experimental group: CMAI
334 A. J. Ledger & F. A. Baker
M ¼ 25.92, SD ¼ 15.42). Total CMAI means for or control; F ¼ 1.61; p ¼ 0.432). This indicated that
both groups fluctuated from one data collection there were no significant differences between the
point to the next. The control group showed a large experimental and control groups in the range and
decrease between the baseline and first reassessment frequency of agitated behaviours manifested
of CMAI, and then a large increase at the next over time.
reassessment (time point 3) before a decline in
agitation at the end of the study (time point 4 and 5).
The experimental group showed an increase
between the baseline and first reassessment of Severity of behaviours
CMAI, followed by a small decrease at the next The means and standard deviations for
CMAI reassessment (time point 3), then an increase CMAI subtype scores (verbal aggressive, verbal
in agitation (time point 4), before returning to an non-aggressive, physical aggressive, and physical
agitation level similar to time points 2 and 3. Control non-aggressive) across the five time points are
group participants showed their highest degree of shown in Table II. In the experimental group, the
agitation at time point 3, but the experimental group course of agitation appeared to remain more stable
showed their highest degree of agitation later, at time for verbal aggressive behaviour (Figure 2) than for
point 4. the other subtypes and are therefore focused on in
The repeated measures multivariate analysis of this paper. However, the repeated measures multi-
variance revealed significant effects within-partici- variate analysis of variance revealed no significant
pants over time (F ¼ 2.61; p50.05), but not
differences between the groups in the manifestation
within-participants over time by group (experimental
of any of the four different types of agitation over
time (verbal non-aggressive F ¼ 0.33, p ¼ 0.57;
45
verbal aggressive F ¼ 0.59; p ¼ 0.45; physical
non-aggressive F ¼ 0.62, p ¼ 0.44; physical aggres-
Experimental
Control sive F ¼ 0.78, p ¼ 0.38). The experimental group did
40
not manifest a significantly lesser degree of
non-aggressive behaviour, nor the more severe
CMAI score
35
aggressive behaviour, over time.
Univariate test results revealed a significant effect
30 of the variables time and group for verbal aggressive
behaviour (F ¼ 2.70; p50.05). It is therefore possi-
25 ble that the experimental group manifested less
verbal aggressive behaviour over time, only the effect
20 size was too small to be detected through multi-
1 2 3 4 5 variate analysis. This interpretation is supported by
Time-point evidence that the experimental group’s levels of
Figure 1. Mean total CMAI scores for the experimental and verbal aggressive behaviour fluctuated less over time
control groups. (Figure 2).
4
music therapy’s success in maintaining participants’
expressive capabilities. During group sessions, music
3 therapy participants shared memories, joked, greeted
2 and complimented others, and commented on the
music, their achievements, and their experiences
1
within sessions. Participants also voiced concerns
0 regarding aging and losses in health, beauty,
1 2 3 4 5
independence and possessions. Some spoke of
Time-point
anger towards family members and nursing staff.
Figure 2. Mean CMAI scores for verbal aggressive behaviour. The treating music therapists noted that few music
therapy participants exhibited declines in verbal
communication skills during the course of the year
Therapists’ observations and improved language functioning has been
reported as an outcome in previous studies of
Prior to sessions, the therapists noted that most
participants wandered, fidgeted, grabbed or insulted music interventions for people with dementia
others, yelled, complained, made anxious statements (Brotons & Koger, 2000; Quinn, 2003;
(e.g., about others stealing), or asked repetitive Sambandham & Schirm, 1995; Smith, 1986;
questions (e.g., asking to ‘‘go home’’). These Suzuki et al., 2004). The verbal non-aggressive
behaviours were seen considerably less frequently behaviour of the music therapy participants steadily
within music therapy sessions and in many cases, increased over the first nine months of the study, also
participants remained less agitated immediately after supporting an improvement in language functioning.
sessions. The control group’s degree of verbal aggressive
and verbal non-aggressive behaviour decreased in
the final six months of the study. This could indicate
Discussion that control participants were losing the ability to
express agitation in a verbal form. Koss et al. (1997)
The results of this study showed interesting trends attributed limited verbal agitation to increasing
with regard to the longitudinal effects of weekly language difficulties in participants in the lower
music therapy sessions on the agitated behaviours of MMSE stratum. Through exercising verbal skills
people with Alzheimer’s disease. First, there were no within music therapy groups, experimental group
significant differences between the two groups in the participants may have sustained abilities that dete-
range and frequency of agitated behaviours mani- riorated in the control group during the course of
fested over time. Furthermore, there were no the study.
significant differences between the groups in the
manifestation of any of the four different agitation
Limitations of the study
subtypes over time.
The finding that there were no significant differ- High inter- and intra-participant variability in agita-
ences between the groups over time may indicate tion levels may account for the lack of significance
that music therapy has only immediate effects on found between the two conditions. The pooled
agitated behaviours displayed by people with sample’s standard deviation values for the
Alzheimer’s disease (rather than cumulative and total CMAI scores were large (Table III) and total
long-term effects). The treating therapists’ observa- CMAI scores fluctuated substantially from one time
tion that music therapy treatment led to short-term point to the next (Figure 1).
reductions in agitation is supported by the findings Furthermore, the control group showed a greater
of other music therapy studies which examined degree of agitation at baseline and time points 3 and
improvements in the behaviour of people with 5, but the experimental group showed a greater
dementia (Brotons & Pickett-Cooper, 1996; degree of agitation at time points 2 and 4.
Fitzgerald-Cloutier, 1993; Groene, 1993; Jennings The observation that participants showed high
& Vance, 2002; Nugent, 2000; Thomas et al., inter- and intra-participant variability over time is
1997). It is plausible that music therapy only reduces consistent with other music and agitation studies
agitation while it is regulating people’s orientation (Casby & Holm, 1994; Clair & Bernstein, 1994;
and arousal levels (Baker, 2002; Ridder, 2003) or Clark, Lipe, & Bilbrey, 1998; Groene, 1993;
promoting a safe and secure environment (Gerdner, Nugent, 2000; Sherratt, Thornton, & Hatton,
1999). The effects of music therapy may disappear 2004a) and reports in general gerontology literature
once the predictable and structural qualities of (Cohen-Mansfield, 1999, 2000; Levy et al., 1996).
336 A. J. Ledger & F. A. Baker
Table III. Total CMAI means and standard deviations for the measures may be particularly effective in detecting
pooled sample.
changes in agitation levels over time (Sherratt et al.,
Time point M SD 2004b).