Please tell your doctor or pharmacist if you are taking or have recently taken any

PACKAGE LEAFLET: INFORMATION FOR THE USER other medicines, including medicines obtained without a prescription.
Glibenclamide 2.5mg Tablets The dose of Glibenclamide may need to be reduced if you are taking the following:
Glibenclamide 5mg Tablets • drugs which are used to treat infections e.g. fluconazole, sulphonamides
(Glibenclamide) • pain killers e.g. aspirin, phenylbutazone
• blood thinning agents e.g. heparin
Read all of this leaflet carefully before you start taking this medicine.
• cholesterol lowering agents e.g. clofibrate
• Keep this leaflet. You may need to read it again.
• anti-depressants e.g. MAOIs, nortriptyline
• If you have any further questions, ask your doctor or pharmacist.
• drugs for high blood pressure and heart failure e.g. captopril, enalapril
• This medicine has been prescribed for you. Do not pass it on to others. It
may harm them, even if their symptoms are the same as yours. • medicines for stomach ulcers and dyspepsia e.g. cimetidine, ranitidine
• If any of the side effects gets serious, or if you notice any side effects not • drugs for obesity and gout
listed in this leaflet, please tell your doctor or pharmacist.
The dose of Glibenclamide may need to be increased if you are taking the
following:
In this leaflet:
• rifampicin.
1. What Glibenclamide Tablets are and what they are used for
2. Before you take Glibenclamide Tablets • tablets for getting rid of water in the body.
3. How to take Glibenclamide Tablets • drugs for high blood pressure and heart trouble.
4. Possible side effects • some products purchased at the chemists may have a high sugar content
5. How to store Glibenclamide Tablets which may raise blood sugar levels.
6. Further information
Taking Glibenclamide Tablets with food and drink:
1. WHAT GLIBENCLAMIDE TABLETS ARE AND WHAT THEY ARE
USED FOR Glibenclamide should be taken with or immediately after food.
Alcohol may cause flushes in some patients and can affect the levels of sugar in
Glibenclamide belongs to a group of medicines known as oral hypoglycaemics your blood.
which are used for the treatment of diabetics who do not need insulin but who
need more than just diet to control their diabetes.
Pregnancy and breast-feeding
2. BEFORE YOU TAKE GLIBENCLAMIDE TABLETS
Tell your doctor if you are pregnant, planning to become pregnant or breast-
Do not take Glibenclamide Tablets: feeding.
• If you are allergic (hypersensitive) to Glibenclamide
Do not breastfeed whilst on Glibenclamide Tablets without advice from your
• If you have severe liver or kidney problems doctor.
• If you have severe thyroid or adrenal gland problems
• If you have ever had a diabetic coma Effects on the ability to drive and use machines:
• When you are under unusual stress such as surgery, trauma or severe infection
If you experience the symptoms of low blood sugar (hypoglycaemia) you should
Take special care with Glibenclamide Tablets: not drive or operate machinery. Low blood sugar may occur at the beginning of
When you are about to do strenuous exercise as this medicine can cause blood treatment while your doctor is trying to find the dose that bests suits you. Your
sugar levels to get too low, known as “hypoglycaemia”. Early warning symptoms doctor will give you further advice. When your blood sugar is stabilized you may
of low blood sugar include faintness, sweating, trembling, confusion or headache. drive or operate machinery.
You will need to eat and drink something sugary quickly.
Important information about some of the ingredients of Glibenclamide
Ask your doctor for more information about the symptoms of hypoglycaemia
and what you should do if it happens. It is important that relatives and close Tablets
workmates know that you have diabetes and are taking medication so that they These tablets contain lactose so take care if you have been told by your doctor
can recognize the symptoms of hypoglycaemia and help if necessary. that you have intolerance to some sugars such as lactose.

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3. HOW TO TAKE GLIBENCLAMIDE TABLETS - Stomach upsets such as nausea, vomiting, abdominal pain, diarrhoea, loss of
appetite or a metallic taste. Taking doses with food may reduce these problems.
Always take Glibenclamide Tablets exactly as your doctor has told you. You They often get better spontaneously so you should continue to take the tablets
should check with your doctor or pharmacist if you are not sure. unless your stomach is upset and shows no sign of getting better after a few days.
These tablets should be taken orally once a day with or immediately after breakfast - Increased appetite and weight gain
or the first main meal of the day. - decrease in the amount of sodium level in your blood (shown by blood tests)
The usual starting dose for Glibenclamide is 2.5 – 5mg which can be increased if any of the side effects gets serious, or if you notice any side effects not listed
if necessary. Your doctor will decide the dose which is best for you. in this leaflet, please tell your doctor or pharmacist.
You should continue to take these tablets for as long as your doctor tells you to.
5. HOW TO STORE GLIBENCLAMIDE TABLETS
If you take more Glibenclamide than you should
If you accidentally take too many Glibenclamide Tablets seek immediate medical Keep out of the reach and sight of children.
advice by contacting your doctor or nearest hospital casualty department. Do not use your medicine after the expiry date shown on the label.
If you forget to take Glibenclamide Tablets The expiry date refers to the last day of the month.
If you forget to take a dose, take the missing dose as soon as you remember, with These tablets should not be stored above 25°C and should be kept in their original
your next meal. If it is time for the next dose do not double the dose to make container to protect them from light and moisture.
up for the one you missed. Medicines should not be disposed of via wastewater or household water. Ask
your pharmacist how to dispose of medicines no longer required. These measures
If you stop taking Glibenclamide Tablets will help protect the environment.
Do not stop taking this medicine without consulting your doctor or pharmacist.
6. FURTHER INFORMATION
If you have any further questions on the use of this medicine, ask your doctor
or pharmacist. What Glibenclamide Tablets contain:
4. POSSIBLE SIDE EFFECTS The active substance is Glibenclamide.
Like all medicines Glibenclamide Tablets can cause some side effects although The 2.5mg tablet contains 2.5mg of glibenclamide and the 5.0mg tablet contains
not everybody gets them. 5.0mg glibenclamide.
If the following happens, stop taking this medicine and tell your doctor immediately The other ingredients are lactose, maize starch, povidone K30 and magnesium
or go to the casualty department at your nearest hospital: stearate.
- Allergic reactions (including inflammation of blood vessels, often with skin What Glibenclamide Tablets look like and the contents of the pack:
rash) which may develop into serious reactions with difficulty in breathing, fall
in blood pressure and sometimes progressing to shock. Glibenclamide 2.5mg Tablets are white, circular tablets marked CP on one face
and GL2.5 on the other.
- Abnormal liver function including yellowing of the skin and eyes (jaundice)
problems with the bile flow (cholestasis), inflammation of the liver (hepatitis) The registered pack sizes are 10, 14, 28, 100, 500 and 1000 tablets.
or liver failure,
Glibenclamide 5mg Tablets are white, capsule-shaped tablets marked CP on one
- Allergy (hypersensitivity) of the skin such as itching, rash, hives and increased face and GL5 on either side of a breakline, on the other face.
sensitivity to sun. Some mild allergic reactions may develop into serious reaction,
which causes severe blistering of the skin, mouth, eyes and genitals. The registered pack sizes are 28, 100, 500 and 1000 tablets.
- Severe hypoglycameia including loss of consciousness, seizures or coma. Some
patients experienced the following side effects whilst taking this medicine. Tell Marketing Authorization Holder and Manufacturer
your doctor if you experience any of the following symptoms:
Aurobindo Pharma Limited,
Rare side effects (affects more than 1 patient in 10,000 and less than 1 patient Ares, Odyssey Business Park,
in 1000 people)
West End Road,
- Lower blood sugar than normal (hypoglycaemia) (See Section 2 - Take special South Ruislip HA4 6QD,
care with Glibenclamide)
United Kingdom
- Decrease in the number of blood cells:
- Blood platelets (which makes infections more likely) PL 20532/0079 POM
- Red blood cells (which can make the skin pale and cause weakness or PL 20535/0080
breathlessness)
Very rare (affects less than 1 patient in 10,000) This leaflet was last approved in {08/2011}.
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