Complete A-G: Nutri-West Presents
Complete A-G: Nutri-West Presents
Complete A-G: Nutri-West Presents
Complete A-G
Researched and Formulated by Dr. Dan Murphy
The mitochondria are “powerhouses of the cell” that produce energy. Supporting and protecting these
powerhouses has played an integral role in overall health and the aging process. It is believed that
mitochondrial decay is a major contributor to aging. As our bodies age, nutrient deficiencies and cell
damage (much of which is caused by free radical attacks) can result in the decay of these energy
powerhouses. Free radical attacks can be caused by many things, including toxic exposure to
chemicals, metals, radiation, drugs, and even heavy exercise. Free radicals damage cells and cause
DNA strand breaks, contributing to the aging process and degenerative diseases. With time, we start to
exhibit a diminished capacity for maintaining and protecting these very important cellular organelles.
Lowered antioxidant status can open the door to increased cell damage, particularly to the vulnerable
mitochondria. The mitochondria are vulnerable because they are a major site for leakage of free
radicals into the system, calling for increased protection.
Two very important nutrients that enhance mitochondrial function are alpha lipoic acid and acetyl-L-
carnitine. Evidence-backed research demonstrates the power of these nutrients to support and protect
the mitochondria. Acetyl-L-carnitine optimizes mitochondrial function, while alpha lipoic acid not
only acts as a building block; it possesses dynamic strength as an antioxidant protector. Studies
report a superior ability of these nutrients to enhance the mitochondria that supply the ATP (energy)
that drives all the biochemical reactions in our bodies to keep us alive and well. In fact, many
researchers state that supplementation of alpha lipoic acid and acetyl-L-carnitine can decrease
mitochondrial decay, and actually restore function and the velocity of key enzyme reactions that have
been diminished by oxidative free radicals (Ames BN, Liu J. Delaying the mitochondrial decay of aging with
acetylcarnitine, Ann N Y Acad Sci. 2004 Nov;1033:108-16).
Another integral and synergistic nutrient for mitochondrial function is coenzyme Q-10 (Co-Q-10).
Co-Q-10 is an electron acceptor in the Kreb’s Cycle, which means that it is vital to the process of
making ATP in the mitochondria. It also acts as an antioxidant, which is highly important, because the
leakage of free radicals from the mitochondria, that is such a main source of oxidative damage,
happens at the very site where Co-Q-10 functions. Since oxidative damage to the mitochondria are
suspected in the etiology of many degenerative diseases, it would make sense that we would see Co-Q-
10 show up as a nutrient receiving focus in scientific studies on mitochondrial health and protection.
That is exactly the case, and one review in particular states that “in coenzyme Q 10 therapy, especially
in areas where this therapeutic approach is completely new; the findings highlight the beneficial role
of coenzyme Q-10 as coadjuvant in the treatment of syndromes characterized by increased oxidative
stress and impaired mitochondrial bioenergetics…:, many improvements were cited, from
cardiovascular/vascular effects and neuroprotective mechanisms, to “migraines and age-related
macular degeneration – in whose pathophysiology mitochondrial dysfunction may play a role”.
(Littarru GP & Tiano L Clinical aspects of coenzyme Q10: an update. Curr Opin Clin Nutr Metab Care, 2005;
8(6): 641-6)
Nutri-West’s Complete A-G:
Each Tablet Contains: Biotin 33 mcg, Magnesium (as chelate) 10 mg, Manganese (as chelate) 0.200
mg. Proprietary blend 241.5 mg* of: Acetyl L-Carnitine (as hydrochloride), Alpha Lipoic Acid, L-
Ornithine Ketoglutarate, Co-Enzyme-Q-10, Phosphatidyl Serine, Pyridoxal-5-Phosphate.
Alpha Lipoic Acid, Acetyl-L-Carnitine and Co-Enzyme Q-10 for Nerve Health:
A meta-analysis of 21 double blind clinical trials shows that acetyl-L-carnitine may be beneficial for
neuronal protection as well (Montgomery, S.A. et al. Int. Clin. Psychopharmacol. 18 (2003), pp.61-71). A
meta-analysis of alpha lipoic acid studies showed benefit for diabetic neuropathic deficits (Ziegler D.
et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-
analysis. Diabet Med. 2004 Fef;21(2):114-21., Nowak H, Kempler P, Vargha P, Low PA.). Additionally, “the
neuroprotective mechanisms of coenzyme Q-10 were demonstrated in studies on different
neurological diseases involving mitochondrial dysfunction and oxidative stress” (Littarryu GP&
Tiano L Clinical aspects of coenzyme Q10: an update. Curr Opin Clin Nutr Metab Care, 2005; 8(6): 641-6.)
Alpha Lipoic Acid and Coenzyme Q-10 in Macular Degeneration:
Many degenerative diseases, including macular degeneration, are thought to evolve as a result of aging
and oxidative damage. Researchers have suggested that nutrients such as acetyl-L-carnitine, coenzyme
Q 10, and fish oil, which “affect mitochondrial lipid metabolism, may improve and subsequently
stabilize visual functions, and it may also improve fundus alterations in patients affected by early
macular degeneration” (Feher Jet al. Improvement of visual functions and fundus alterations in early age-
related macular degeneration treated with a combination of acetyl-L-carnitine, n-3 fatty acids, and co Q-10.
Ophthalmologica. 2005 May-Jun;219(3):154-66)
Other synergistic nutrients in Complete A-G: Many other nutrients help to maintain the function and
health of our energy-producing mitochondria. Among them, some of the most important that stand out
are the B vitamins biotin and pyridoxal-5-phosphate (activated B-6, involved in energy co-enzymes),
magnesium (needed for over 200 biological reactions, including energy production), and manganese
(needed for co-enzymes and the antioxidant enzyme SOD). When the lipid metabolism and
mitochondrial enzyme function of the aging brain was studied, researchers demonstrated that
supplementation with phosphatidyl serine “was able to balance the enzymatic functions altered by
aging in several OF the areas examined” (Gatti C et al. Effect of chronic treatment with phosphatidyl serine
on phospholipase A1 and A2 activities in different brain areas of 4 month and 24 month old rats. Farmaco
[Sci]. 1985 Jul;p40(7):493-500) L-Ornithine Ketoglutarate is one of the amino acids known to help
release GH. Supplementation of ornithine has been reported to stimulate the release of GH from the
pituitary (Pearson, D and Shaw, S.Life Extension. New York:Warner Books, 1982:289-290.) Growth
hormone decline with aging has been suggested to be tied to the cause of aging. (Harman SM. Use of
growth hormone for prevention of effects of aging. Ann N Y Acad Sci. 2005 Dec;1055:229-30.)
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The above statements have not been evaluated by the FDA. The nutritional information, suggestions, and research provided are not
intended to diagnose, treat, cure, or prevent disease and should not be used as a substitute for sound medical advice. Please see your
health care professional in all matters pertaining to your physical health.