PVC Unido ConDuplicados

TY - JOUR
AB - Cardiogenic embolism has accounted for one in six ischemic strokes in recent
clinical studies. We review the recent clinical literature about the natural
history, diagnosis, and management of cardioembolic stroke. Long-term
anticoagulation may be indicated for primary stroke prevention in high-risk patient
subgroups with non-rheumatic atrial fibrillation. The prevalence of left
ventricular thrombi, and probably also emboli, following an acute anterior
myocardial infarction has been reduced by heparin, but the value of subsequent oral
anticoagulation for persistent left ventricular thrombi has been disputed. Two
clinical subgroups of mitral valve prolapse have been emerging: one benign and the
other prone to complications, including embolism. Paradoxical embolism has
increasingly been reported as contrast echocardiography has permitted a reliable
diagnosis of patent foramen ovale. The embolic risk of infective endocarditis is
low (less than 5%) when infection is controlled; early embolism during uncontrolled
infection does not strongly predict later stroke. Low-intensity anticoagulation
(international normalized ratio, 2.0 to 3.0) may be sufficient prophylaxis for many
embolism-prone cardiac disorders.
AN - 2662950
DA - Jul
DP - NLM
ET - 1989/07/01
IS - 7
J2 - Archives of neurology
KW - Atrial Fibrillation/complications
Cerebrovascular Disorders/epidemiology/*etiology
Coronary Disease/*complications
Coronary Thrombosis/complications
Embolism/*complications
Endocarditis/complications
Humans
Intracranial Embolism and Thrombosis/*etiology
Ischemic Attack, Transient/epidemiology/etiology
Mitral Valve Prolapse/complications
Myocardial Infarction/complications
LA - eng
N1 - Journal Article
Review
United States
Arch Neurol. 1989 Jul;46(7):727-43.
PY - 1989
SN - 0003-9942 (Print)
0003-9942
SP - 727-43
ST - Cardiogenic brain embolism. The second report of the Cerebral Embolism Task
Force
T2 - Arch Neurol
TI - Cardiogenic brain embolism. The second report of the Cerebral Embolism Task
Force
VL - 46
ID - 2550
ER -
TY - JOUR
AB - The multiplication of the indication of radiofrequency for curative or
palliative treatment of cardiac arrhythmias motivated the Rhythmology Working Group
to set up a register of the complications related to this technique. Five thousand
six hundred and eighty nine cases from 19 French centres were recensed up to March
1996. There were 2765 ablations of a Bundle of Kent, 1579 ablations of slow
pathways, 621 ablations of atrial flutter, 25 ablations of atrial tachycardia, 200
ablations of ventricular tachycardia and 499 ablations of the Bundle of His. Eighty
five complications (1.5%), two of which were lethal (0.04%), were reported. The
complications of catheterization (27% of all complications) were pneumothorax (n =
6), arterial thrombosis (n = 3), venous thrombosis with and without pulmonary
embolism (n = 8), haematoma (n = 2), femoral pseudoaneurysm (n = 1), arteriovenous
fistula (n = 1), infection (n = 2), valvular disease with mitral or aortic
regurgitation (n = 3). Other complications were specific to the ablation
itself:skin burns at the site of the patch (n = 2), ventricular fibrillation (n =
3), coronary events (n = 2), vascular events (n = 2), tamponade (n = 12), one of
which was lethal, and transient or permanent complete atrioventricular block (n =
32) complicating ablation of antero and posteroseptal accessory pathways, atrial
flutter and slow intranodal reentry pathways (n = 25). One lethal cerebral
haemorrhage occurred the day after an ablation procedure. It was not possible to
identify a predictive factor in these complications apart from the operator's
experience. There were 1.4% of complications in Kent bundle ablations, 1.9% in
ablation of slow pathway, 0.6% in atrial flutter and tachycardia, 1.5% for
ventricular tachycardia and 1.9% for Bundle of His. The authors concluded that the
prevalence of complications, though small with minimal risk of mortality (0.04%),
should incite physicians to reserve this technique for symptomatic patients or
those with potentially lethal arrhythmias.
AN - 9137725
DA - Dec
DP - NLM
ET - 1996/12/01
IS - 12
J2 - Archives des maladies du coeur et des vaisseaux
KW - Arrhythmias, Cardiac/*surgery
Catheter Ablation/*adverse effects/methods/statistics & numerical data
France/epidemiology
Heart Conduction System/surgery
Humans
Incidence
Retrospective Studies
Risk Factors
Time Factors
LA - fre
N1 - English Abstract
Journal Article
Multicenter Study
Review
France
Arch Mal Coeur Vaiss. 1996 Dec;89(12):1599-605.
OP - Complications des ablations par radiofréquence. Expérience française. Le
Groupe de Rythmologie de la Société Française de Cardiologie.
PY - 1996
SN - 0003-9683 (Print)
0003-9683
SP - 1599-605
ST - [Complications of radiofrequency ablation: A French experience. Le Groupe de
Rythmologie de la Société Francaise de Cardiologie]
T2 - Arch Mal Coeur Vaiss
TI - [Complications of radiofrequency ablation: A French experience. Le Groupe de
Rythmologie de la Société Francaise de Cardiologie]
VL - 89
ID - 2902
ER -
TY - JOUR
AB - The Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM)
Study is a randomized evaluation of treatment of atrial fibrillation by 1 of 2
strategies: ventricular rate control and anticoagulation versus rhythm control and
anticoagulation. The primary end point is total mortality, analyzed by intention-
to-treat. Secondary end points are composite end points (total mortality, disabling
intracranial bleed [subdural and/or subarachnoid hemorrhage], stroke [embolus,
thrombosis, hemorrhage], disabling anoxic encephalopathy, cardiac arrest, major
noncentral nervous system bleed), cost of therapy, and quality of life. AFFIRM will
randomize therapy and follow 5,300 patients for an average of 3.5 years (minimum 2
years) at 200 sites in the United States and Canada.
AN - 9164885
DA - May 1
DP - NLM
ET - 1997/05/01
IS - 9
J2 - The American journal of cardiology
KW - Adrenergic beta-Antagonists/*therapeutic use
Aged
Anti-Arrhythmia Agents/*therapeutic use
Atrial Fibrillation/complications/mortality/*therapy
Cardiac Pacing, Artificial
Catheter Ablation
Cerebral Hemorrhage/etiology
Cerebrovascular Disorders/etiology
Electrocardiography, Ambulatory
Fibrinolytic Agents/administration & dosage
Follow-Up Studies
Heart Arrest/etiology
Heart Rate/drug effects
Hemorrhage/etiology
Humans
Multicenter Studies as Topic/methods
Patient Selection
Quality of Life
Randomized Controlled Trials as Topic/*methods
Recurrence
Research Design
Risk Factors
Survival Rate
LA - eng
N1 - N01-HC-55139/HC/NHLBI NIH HHS/United States
Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.
United States
Am J Cardiol. 1997 May 1;79(9):1198-202.
PY - 1997
SN - 0002-9149 (Print)
0002-9149
SP - 1198-202
ST - Atrial fibrillation follow-up investigation of rhythm management -- the
AFFIRM study design. The Planning and Steering Committees of the AFFIRM study for
the NHLBI AFFIRM investigators
T2 - Am J Cardiol
TI - Atrial fibrillation follow-up investigation of rhythm management -- the
AFFIRM study design. The Planning and Steering Committees of the AFFIRM study for
the NHLBI AFFIRM investigators
VL - 79
ID - 2987
ER -
TY - JOUR
AB - A multicenter, retrospective study was undertaken to determine the prevalence
of and risk factors for thromboembolism and efficacy of therapy in patients with
atrial fibrillation. The primary prevention group consisted of 1,819 Japanese
patients (mean age 64 years). During the mean follow-up period of 4.6 years. 158
patients developed cerebral thromboembolism or peripheral embolism (1.9%/year). The
annual rate of thromboembolic complications was 0.9% for patients without
underlying heart disease which was significantly lower compared with that for
patients with underlying heart disease (p < 0.001). The annual rate was 1.4% among
patients treated with aspirin (alone and in combination with other drugs except for
warfarin), 1.4% with warfarin (alone and in combination with other drugs) and 1.1%
with ticlopidine. The risk was lower for patients receiving these drugs (2.2%/year,
p < 0.001). Among 801 patients not receiving treatment for thromboembolism, the
annual rate was 0.9% for patients without underlying heart disease, which was
significantly lower compared with patients with underlying heart diseases (e.g.,
2.5% for ischemic heart disease and 2.1% for mitral valve disease, p < 0.001).
Multivariate analysis using quantification method II revealed hypertension, sick
sinus syndrome and left ventricular dysfunction (> or = NYHA class II) as risk
factors for embolism. Although limited due to its retrospective nature, the present
study suggests that the risk for embolism seems low in patients with atrial
fibrillation but is not associated with underlying heart diseases or other risk
factors, and antiplatelet treatment seems beneficial for these patients.
AN - 9594372
DA - Apr
DP - NLM
ET - 1998/05/22
IS - 4
J2 - Journal of cardiology
KW - Anticoagulants/*therapeutic use
Aspirin/therapeutic use
Atrial Fibrillation/*complications
Dipyridamole/therapeutic use
Female
Heart Diseases/drug therapy
Humans
Male
Middle Aged
Multivariate Analysis
Platelet Aggregation Inhibitors/*therapeutic use
Prevalence
Prognosis
Risk Factors
Thromboembolism/epidemiology/*etiology/prevention & control
Ticlopidine/therapeutic use
Warfarin/therapeutic use
LA - jpn
N1 - English Abstract
Journal Article
Multicenter Study
Netherlands
J Cardiol. 1998 Apr;31(4):227-38.
PY - 1998
SN - 0914-5087 (Print)
0914-5087
SP - 227-38
ST - [Atrial fibrillation and thromboembolism: a multicenter cooperative study.
Research Group for Antiarrhythmic Drug Therapy]
T2 - J Cardiol
TI - [Atrial fibrillation and thromboembolism: a multicenter cooperative study.
Research Group for Antiarrhythmic Drug Therapy]
VL - 31
ID - 3048
ER -
TY - JOUR
AB - BACKGROUND: Cardiac arrest with widespread cerebral ischemia frequently leads
to severe neurologic impairment. We studied whether mild systemic hypothermia
increases the rate of neurologic recovery after resuscitation from cardiac arrest
due to ventricular fibrillation. METHODS: In this multicenter trial with blinded
assessment of the outcome, patients who had been resuscitated after cardiac arrest
due to ventricular fibrillation were randomly assigned to undergo therapeutic
hypothermia (target temperature, 32 degrees C to 34 degrees C, measured in the
bladder) over a period of 24 hours or to receive standard treatment with
normothermia. The primary end point was a favorable neurologic outcome within six
months after cardiac arrest; secondary end points were mortality within six months
and the rate of complications within seven days. RESULTS: Seventy-five of the 136
patients in the hypothermia group for whom data were available (55 percent) had a
favorable neurologic outcome (cerebral-performance category, 1 [good recovery] or 2
[moderate disability]), as compared with 54 of 137 (39 percent) in the normothermia
group (risk ratio, 1.40; 95 percent confidence interval, 1.08 to 1.81). Mortality
at six months was 41 percent in the hypothermia group (56 of 137 patients died), as
compared with 55 percent in the normothermia group (76 of 138 patients; risk ratio,
0.74; 95 percent confidence interval, 0.58 to 0.95). The complication rate did not
differ significantly between the two groups. CONCLUSIONS: In patients who have been
successfully resuscitated after cardiac arrest due to ventricular fibrillation,
therapeutic mild hypothermia increased the rate of a favorable neurologic outcome
and reduced mortality.
AN - 11856793
DA - Feb 21
DO - 10.1056/NEJMoa012689
DP - NLM
ET - 2002/02/22
IS - 8
J2 - The New England journal of medicine
KW - Brain Diseases/etiology/*prevention & control
Cardiopulmonary Resuscitation
Heart Arrest/etiology/mortality/*therapy
Humans
*Hypothermia, Induced
Hypoxia-Ischemia, Brain/complications
Logistic Models
Single-Blind Method
Survival Analysis
Treatment Outcome
Ventricular Fibrillation/complications/therapy
LA - eng
N1 - 1533-4406
Hypothermia after Cardiac Arrest Study Group
Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
United States
N Engl J Med. 2002 Feb 21;346(8):549-56. doi: 10.1056/NEJMoa012689.
PY - 2002
SN - 0028-4793
SP - 549-56
ST - Mild therapeutic hypothermia to improve the neurologic outcome after cardiac
arrest
T2 - N Engl J Med
TI - Mild therapeutic hypothermia to improve the neurologic outcome after cardiac
arrest
VL - 346
ID - 2908
ER -
TY - JOUR
AN - 15106548
DA - Oct
DP - NLM
ET - 2004/04/27
IS - 10
J2 - Heart advisor
KW - Atrial Fibrillation/*complications
Heart Arrest/*etiology
Humans
Stroke/*etiology
Ventricular Fibrillation/*complications
LA - eng
N1 - Journal Article
United States
Heart Advis. 2003 Oct;6(10):8.
PY - 2003
SN - 1523-9004 (Print)
1523-9004
SP - 8
ST - I have atrial fibrillation. What's the difference between my condition and
ventricular fibrillation? How do they compare as risk factors for cardiac arrest?
T2 - Heart Advis
TI - I have atrial fibrillation. What's the difference between my condition and
ventricular fibrillation? How do they compare as risk factors for cardiac arrest?
VL - 6
ID - 2760
ER -
TY - JOUR
AB - BACKGROUND: Although evidence supports the prophylactic use of beta-blockade
in cardiac surgery, postoperative atrial fibrillation or flutter occurs in 40% to
60% of patients. Trials that assessed whether amiodarone prophylaxis decreases the
incidence of postoperative atrial tachyarrhythmias have had mixed results and were
not specifically powered to detect changes in cardiovascular morbidity, length of
stay, or mortality. PURPOSE: To see whether prophylactic administration of
amiodarone decreases the incidence of major cardiovascular events, length of stay,
and mortality after cardiac surgery. DATA SOURCES: English-language and non-
English-language publications listed in the MEDLINE, EMBASE, and CINAHL databases
and the Cochrane Central Register of Controlled Trials, and bibliographies of
published reviews. Sources were searched from the earliest possible dates through
February 2005. STUDY SELECTION: Double-blind, randomized studies comparing
amiodarone with placebo that reported the incidence of supraventricular arrhythmia,
atrial fibrillation, or atrial flutter as the primary end point. DATA EXTRACTION:
Two investigators independently collected all data. Discrepancies were resolved by
consensus. DATA SYNTHESIS: After DerSimonian-Laird random-effects models were used
to combine data from 10 trials involving 1744 patients, amiodarone therapy was
found to decrease the incidence of atrial fibrillation or flutter (relative risk,
0.64 [95% CI, 0.55 to 0.75]), ventricular tachycardia and fibrillation (relative
risk, 0.42 [CI, 0.28 to 0.63]), stroke (relative risk, 0.39 [CI, 0.21 to 0.76]),
and length of stay (weighted mean difference, -0.63 day [CI, -1.03 to -0.23 days]).
All studies reported adverse events, but none indicated how these events were
assessed. Three studies found significantly more adverse events with amiodarone
therapy, including nausea permitting continuation of therapy, bradycardia of
unclear clinical significance, and increased intensive care monitoring and support.
LIMITATIONS: Not all studies used beta-blockade, and regimens were not uniform
among trials. Few trials met the stringent inclusion criteria, some did not report
each type of cardiovascular event, and none reported completeness of follow-up.
CONCLUSIONS: Amiodarone prophylaxis decreases the occurrence of atrial
fibrillation, ventricular tachyarrhythmias, and stroke and length of stay after
cardiac surgery. To further evaluate the potential benefits of concomitant
prophylaxis with beta-blockers and amiodarone, a multicenter, randomized, double-
blind trial with cardiovascular outcomes that compares amiodarone with placebo in
patients already receiving beta-blocker prophylaxis is needed.
AD - Rush University Medical Center, Chicago, Illinois 60612, USA.
AN - 16144891
AU - Aasbo, J. D.
AU - Lawrence, A. T.
AU - Krishnan, K.
AU - Kim, M. H.
AU - Trohman, R. G.
DA - Sep 6
DO - 10.7326/0003-4819-143-5-200509060-00008
DP - NLM
ET - 2005/09/08
IS - 5
J2 - Annals of internal medicine
KW - Amiodarone/*therapeutic use
Arrhythmias, Cardiac/prevention & control
Atrial Fibrillation/prevention & control
Atrial Flutter/prevention & control
Cardiac Surgical Procedures/*adverse effects
Cardiovascular Diseases/etiology/*prevention & control
Humans
Length of Stay
Myocardial Infarction/prevention & control
Stroke/prevention & control
LA - eng
N1 - 1539-3704
Aasbo, Johan D
Lawrence, Andrew T
Krishnan, Kousik
Kim, Michael H
Trohman, Richard G
Journal Article
Meta-Analysis
United States
Ann Intern Med. 2005 Sep 6;143(5):327-36. doi: 10.7326/0003-4819-143-5-200509060-
00008.
PY - 2005
SN - 0003-4819
SP - 327-36
ST - Amiodarone prophylaxis reduces major cardiovascular morbidity and length of
stay after cardiac surgery: a meta-analysis
T2 - Ann Intern Med
TI - Amiodarone prophylaxis reduces major cardiovascular morbidity and length of
stay after cardiac surgery: a meta-analysis
VL - 143
ID - 2644
ER -
TY - JOUR
AB - OBJECTIVE: Brain injuries may induce cardiac dysrhythmias and sudden cardiac
death. METHODS: We analyzed 12-lead electrocardiograms of 493 consecutive patients
with brain infarction (BI) proved by an magnetic resonance imaging and 493 control
subjects matched for age, sex, and center. Insular involvement (insula (+/-)) was
assessed by two independent readings of the magnetic resonance imaging scans. Cases
were followed for 5 years. RESULTS: Acute BI was independently associated with
heart rate (< or = 64 beats/min), abnormal repolarization, atrial fibrillation, and
ventricular and supraventricular ectopic beats. Lower heart rate in BI patients was
due to an interaction with smoking (p for interaction = 0.004). Insula(+) group was
significantly associated with abnormal repolarization with no interaction with
infarct side. Atrial fibrillation by history was also more frequent in the
insula(+) than in the insula(-) group (p = 0.07). After adjustment for age, sex,
cardiovascular history, and handicap at admission, right insula(+) BI was
significantly associated with 2-year all-cause death (hazard ratio, 2.11; 95%
confidence interval, 1.27-3.52) and with vascular death (hazard ratio, 2.00; 95%
confidence interval, 1.00-3.93). In multivariate analysis including age, sex,
cardiovascular history, handicap at admission, and lesion side, increased QTc
interval and left bundle branch block were independent predictors of all-cause and
vascular mortality at 2 years in right insula(+) patients. INTERPRETATION: These
findings support the notion that right insular involvement may lead to
electrocardiographic abnormalities with potential prognostic implications. This
could be important for optimal care in patients with right insular infarct.
AD - Department of Neurology and Stroke Centre, Bichat University Hospital, Denis
Diderot University and Medical School, Paris, France.
AN - 16566012
AU - Abboud, H.
AU - Berroir, S.
AU - Labreuche, J.
AU - Orjuela, K.
AU - Amarenco, P.
DA - Apr
DO - 10.1002/ana.20806
DP - NLM
ET - 2006/03/28
IS - 4
J2 - Annals of neurology
KW - Adult
Aged
Aged, 80 and over
Arrhythmias, Cardiac/*etiology/*mortality
Brain Infarction/*complications/pathology
Case-Control Studies
Electrocardiography/methods
Female
Follow-Up Studies
Functional Laterality
Humans
Magnetic Resonance Imaging/methods
Male
Middle Aged
Proportional Hazards Models
Statistics, Nonparametric
Survival Analysis
Survival Rate
LA - eng
N1 - Abboud, Halim
Berroir, Stéphane
Labreuche, Julien
Orjuela, Karen
Amarenco, Pierre
GENIC Investigators
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
United States
Ann Neurol. 2006 Apr;59(4):691-9. doi: 10.1002/ana.20806.
PY - 2006
SN - 0364-5134 (Print)
0364-5134
SP - 691-9
ST - Insular involvement in brain infarction increases risk for cardiac arrhythmia
and death
T2 - Ann Neurol
TI - Insular involvement in brain infarction increases risk for cardiac arrhythmia
and death
VL - 59
ID - 2321
ER -
TY - JOUR
AB - BACKGROUND: Although the use of transcatheter aortic valve replacement (TAVR)
has recently become an attractive strategy in prohibitive surgical high-risk
patients undergoing aortic valve replacement (AVR), the most appropriate treatment
option in patients with an intermediate- to high-risk profile- whether conventional
surgery (SAVR) or TAVR-has been widely debated. METHODS: One hundred and forty-
three consecutive patients with intermediate to high risk were prospectively
enrolled and selected to undergo SAVR (Group 1 [G1], n = 63) or TAVR (Group 2 [G2],
n = 80) following a multidisciplinary evaluation including frailty, anatomy, and
degree of atherosclerotic disease of the aorta/peripheral vessels. The mean
logistic EuroSCORE (G1 = 20.11 ± 7.144 versus G2 = 23.33 ± 8.97; P = .022), STS
score (G1 = 5.722 ± 1.309 versus G2 = 5.958 ± 1.689; P = .347), and preoperative
demographics such as sex, left ventricular ejection fraction (LVEF), body mass
index (BMI), peripheral vascular disease, diabetes, atrial fibrillation, renal
impairment and syncope were similar. Of note, chronic obstructive pulmonary disease
was more frequent in TAVR patients (G2 [46.2%] versus G1 [19.0%]; P = .001),
whereas pulmonary hypertension was more frequent in SAVR group (G1 [47.6%] versus
G2 [17.5%]; P = .000). The SAVR was performed with either a mechanical or tissue
valve; meanwhile, TAVR was performed with either Core valve prosthesis or Edwards-
Sapiens XT valve. RESULTS: SAVR group showed higher incidence of some postoperative
complications compared to TAVR, namely, postoperative bleeding (4.8% versus 0.0%; P
= .048), tamponade (4.8% versus 0.0%; P = .048) and postoperative atrial
fibrillation (34.9% versus 10.0%; P = .000), whereas TAVR group had a higher
incidence of other sets of postoperative complications, namely, left bundle branch
block (58.8% versus 4.8%; P = .000), need for permanent pacemaker implantation
(25.0% versus 1.6%; P = .000) and peripheral vascular complications (15.0% versus
0.0%; P = .001). On the contrary, when the two groups were compared they did not
show any significant difference regarding anemia requiring more than two units of
blood transfusion, postoperative renal failure, stroke, myocardial infarction, and
hospital mortality. P = .534, .873, .258, .373 and .072 respectively. Hospital
mortality was similar among the two groups (G1 = 0% versus G2 = 5%; P = .072). At
the 24-month follow-up, overall mortality, major adverse cardiac and
cerebrovascular events were comparable between the two groups but prosthetic
regurgitation was better in SAVR group (G2 = 8 patients [10.0%] versus G1 = 1
patient [1.6%] in SAVR group; P = .040). CONCLUSION: In this study, we could not
detect an advantage in survival when SAVR or TAVR were utilized in intermediate to
high surgical risk patients needing aortic valve replacement for severe aortic
stenosis.
AD - Department of Cardiac Surgery, Madinah Cardiac Centre, Kingdom of Saudi
Arabia. a_ewais@yahoo.com.
AN - 31596707
AU - Abdelgawad, A. M. E.
AU - Hussein, M. A.
AU - Naeim, H.
AU - Abuelatta, R.
AU - Alghamdy, S.
DA - Aug 27
DO - 10.1532/hsf.2243
DP - NLM
ET - 2019/10/10
IS - 5
J2 - The heart surgery forum
KW - Aged
Aged, 80 and over
Aortic Valve/*surgery
Aortic Valve Stenosis/*surgery
Atrial Fibrillation/etiology
Bundle-Branch Block/etiology
Cardiac Tamponade/etiology
Female
Heart Valve Prosthesis
Heart Valve Prosthesis Implantation/adverse effects/*methods/mortality
Hospital Mortality
Humans
Hypertension, Pulmonary/complications
Male
Middle Aged
Myocardial Infarction/etiology
Postoperative Complications/*etiology
Postoperative Hemorrhage/etiology
Prosthesis Design
Pulmonary Disease, Chronic Obstructive/complications
Stroke/etiology
Transcatheter Aortic Valve Replacement/adverse effects/methods/mortality
Treatment Outcome
LA - eng
N1 - 1522-6662
Abdelgawad, Ahmed Moustafa Ewiss
Hussein, Mohamed A
Naeim, Hesham
Abuelatta, Reda
Alghamdy, Saleh
Comparative Study
Journal Article
United States
Heart Surg Forum. 2019 Aug 27;22(5):E331-E339. doi: 10.1532/hsf.2243.
PY - 2019
SN - 1098-3511
SP - E331-e339
ST - A Comparative Study of TAVR versus SAVR in Moderate and High-Risk Surgical
Patients: Hospital Outcome and Midterm Results
T2 - Heart Surg Forum
TI - A Comparative Study of TAVR versus SAVR in Moderate and High-Risk Surgical
Patients: Hospital Outcome and Midterm Results
VL - 22
ID - 2320
ER -
TY - JOUR
AB - BACKGROUND: Our aim was to describe the incidence and predictors of stroke in
patients who have heart failure without atrial fibrillation (AF). METHODS AND
RESULTS: We pooled 2 contemporary heart failure trials, the Controlled Rosuvastatin
in Multinational Trial Heart Failure (CORONA) and the Gruppo Italiano per lo Studio
della Sopravvivenza nell'Insufficienza cardiaca-Heart Failure trial (GISSI-HF). Of
the 9585 total patients, 6054 did not have AF. Stroke occurred in 165 patients
(4.7%) with AF and in 206 patients (3.4%) without AF (rates 16.8/1000 patient-years
and 11.1/1000 patient-years, respectively). Using Cox proportional-hazards models,
we identified the following independent predictors of stroke in patients without AF
(ranked by χ(2) value): age (hazard ratio, 1.34; 95% confidence interval, 1.18-1.63
per 10 years), New York Heart Association class (1.60, 1.21-2.12 class III/IV
versus II), diabetes mellitus treated with insulin (1.87, 1.22-2.88), body mass
index (0.74, 0.60-0.91 per 5 kg/m(2) up to 30), and previous stroke (1.81, 1.19-
2.74). N-terminal pro B-type natriuretic peptide (available in 2632 patients) was
also an independent predictor of stroke (hazard ratio, 1.31; 1.11-1.57 per log
unit) when added to this model. With the use of a risk score formulated from these
predictors, we found that patients in the upper third of risk had a rate of stroke
that approximated the risk in patients with AF. CONCLUSIONS: A small number of
demographic and clinical variables identified a subset of patients who have heart
failure without AF at a high risk of stroke.
AD - From Institute of Cardiovascular and Medical Sciences, University of Glasgow,
United Kingdom (A.H.A.-R., A.-C.P., R.L.F., P.S.J., K.R.L., J.J.V.M.); IRCCS-RL:
Istituto Mario Negri, Milan, Italy (R.L.); Consorzio Mario Negri Sud, S Maria
Imbaro, Italy (G.T.); Sahlgrenska Academy, Gothenburg University, Sweden (J.W.);
Rikshospitalet University Hospital, Oslo, Norway (J.K.); University of Birmingham,
Centre for Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom
(G.Y.H.L.); Aalborg Thrombosis Research Unit, Department of Clinical Medicine,
Aalborg University, Aalborg, Denmark (G.Y.H.L.); ANMCO Research Center, Florence,
Italy (A.P.M.); and Maria Cecilia Hospital, GVM Care&Research - E.S. Health Science
Foundation, Cotignola, Italy (L.T.).
From Institute of Cardiovascular and Medical Sciences, University of Glasgow,
United Kingdom (A.H.A.-R., A.-C.P., R.L.F., P.S.J., K.R.L., J.J.V.M.); IRCCS-RL:
Istituto Mario Negri, Milan, Italy (R.L.); Consorzio Mario Negri Sud, S Maria
Imbaro, Italy (G.T.); Sahlgrenska Academy, Gothenburg University, Sweden (J.W.);
Rikshospitalet University Hospital, Oslo, Norway (J.K.); University of Birmingham,
Centre for Cardiovascular Sciences, City Hospital, Birmingham, United Kingdom
(G.Y.H.L.); Aalborg Thrombosis Research Unit, Department of Clinical Medicine,
Aalborg University, Aalborg, Denmark (G.Y.H.L.); ANMCO Research Center, Florence,
Italy (A.P.M.); and Maria Cecilia Hospital, GVM Care&Research - E.S. Health Science
Foundation, Cotignola, Italy (L.T.). john.mcmurray@glasgow.ac.uk.
AN - 25810334
AU - Abdul-Rahim, A. H.
AU - Perez, A. C.
AU - Fulton, R. L.
AU - Jhund, P. S.
AU - Latini, R.
AU - Tognoni, G.
AU - Wikstrand, J.
AU - Kjekshus, J.
AU - Lip, G. Y.
AU - Maggioni, A. P.
AU - Tavazzi, L.
AU - Lees, K. R.
AU - McMurray, J. J.
DA - Apr 28
DO - 10.1161/circulationaha.114.013760
DP - NLM
ET - 2015/03/27
IS - 17
J2 - Circulation
KW - Adult
Aged
Aged, 80 and over
Benzimidazoles/therapeutic use
Biomarkers/blood
Cardiovascular Agents/therapeutic use
Diabetes Mellitus, Type 1/complications
Fatty Acids, Omega-3/*therapeutic use
Female
Fluorobenzenes/*therapeutic use
Follow-Up Studies
Heart Failure/complications/*drug therapy
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use
Kaplan-Meier Estimate
Male
Middle Aged
Natriuretic Peptide, Brain/*blood
Peptide Fragments/*blood
Pyrimidines/*therapeutic use
Randomized Controlled Trials as Topic
Risk Factors
Rosuvastatin Calcium
Stroke/epidemiology/*etiology/prevention & control
Stroke Volume
Sulfonamides/*therapeutic use
Tetrazoles/therapeutic use
atrial fibrillation
heart failure
sinus rhythm
stroke
ventricular ejection fraction
LA - eng
N1 - 1524-4539
Abdul-Rahim, Azmil H
Perez, Ana-Cristina
Fulton, Rachael L
Jhund, Pardeep S
Latini, Roberto
Tognoni, Gianni
Wikstrand, John
Kjekshus, John
Lip, Gregory Y H
Maggioni, Aldo P
Tavazzi, Luigi
Lees, Kennedy R
McMurray, John J V
Investigators of the Controlled Rosuvastatin Multinational Study in Heart Failure
(CORONA)
GISSI-Heart Failure (GISSI-HF) Committees and Investigators
MR/N003403/1/MRC_/Medical Research Council/United Kingdom
Journal Article
Meta-Analysis
United States
Circulation. 2015 Apr 28;131(17):1486-94; discussion 1494. doi:
10.1161/CIRCULATIONAHA.114.013760. Epub 2015 Mar 25.
PY - 2015
SN - 0009-7322
SP - 1486-94; discussion 1494
ST - Risk of Stroke in Chronic Heart Failure Patients Without Atrial Fibrillation:
Analysis of the Controlled Rosuvastatin in Multinational Trial Heart Failure
(CORONA) and the Gruppo Italiano per lo Studio della Sopravvivenza
nell'Insufficienza Cardiaca-Heart Failure (GISSI-HF) Trials
T2 - Circulation
TI - Risk of Stroke in Chronic Heart Failure Patients Without Atrial Fibrillation:
Analysis of the Controlled Rosuvastatin in Multinational Trial Heart Failure
(CORONA) and the Gruppo Italiano per lo Studio della Sopravvivenza
nell'Insufficienza Cardiaca-Heart Failure (GISSI-HF) Trials
VL - 131
ID - 2563
ER -
TY - JOUR
AB - Hypertension-hypervolemia therapy (HHT) is widely employed for treatment
against vasospasm after subarachnoid hemorrhage (SAH). A few investigations have
been reported to establish the fact that HHT results in a high incidence of
congestive heart failure and pulmonary edema as well as deterioration of brain
edema. From the point of view that the cerebral circulation is not independent of
the systemic circulation, the authors investigated the effect of HHT on the
systemic circulation of patients with SAH. In 72 patients, intracranial pressure
(ICP), pulmonary catheter wedge pressure (PCWP), pulmonary arterial pressure (PA),
central venous pressure (CVP), arterial pressure (AP), cardiac index (CI), arterial
blood gas (ABGS), electrocardiogram (ECG), serum and urine electrolytes were
monitored postoperatively. Furthermore, among these patients, the flow (Flow),
volume (Volume) and velocity (Velocity) of the cortical vessels were monitored by
means of a Laser Doppler in 25 patients. A cisternal or spinal drain was placed in
all of the patients. Elevation of PCWP and CVP and Flow were observed when 300ml of
10% glycerol was administered within a period of 30 minutes, whereas administration
of the same dose of glycerol over a period of 60 or 120 minutes caused no
significant changes on these parameters. Elevation of PCWP and CVP and decrease of
CI and Flow, occasionally associated with premature ventricular contraction (PVC),
were observed in some patients when 100ml of 25% albumin was administered. However,
administration of the same dose of albumin over a period of 120 or 240 minutes did
not cause deterioration of the cardiac function. These facts could be explained by
Guyton's law in which massive transfusion causes cardiac dysfunction.(ABSTRACT
TRUNCATED AT 250 WORDS)
AD - Department of Neurosurgery, Jikei University School of Medicine.
AN - 1570056
AU - Abe, S.
AU - Wada, T.
AU - Miyazaki, Y.
AU - Kanki, T.
AU - Hashimoto, T.
AU - Nakamura, N.
DA - Apr
DP - NLM
ET - 1992/04/01
IS - 4
J2 - No shinkei geka. Neurological surgery
KW - Aged
Blood Circulation
*Blood Pressure
*Blood Volume
Cerebrovascular Circulation
Heart Failure/etiology
Hemodynamics
Humans
Intracranial Aneurysm/complications
Intracranial Pressure
Ischemic Attack, Transient/physiopathology/*therapy
Male
Middle Aged
Subarachnoid Hemorrhage/complications
Treatment Outcome
LA - jpn
N1 - Abe, S
Wada, T
Miyazaki, Y
Kanki, T
Hashimoto, T
Nakamura, N
Case Reports
English Abstract
Journal Article
Japan
No Shinkei Geka. 1992 Apr;20(4):357-65.
PY - 1992
SN - 0301-2603 (Print)
0301-2603
SP - 357-65
ST - [Serious pitfalls which can be encountered in a course of hypertension-
hypervolemia therapy for vasospasm]
T2 - No Shinkei Geka
TI - [Serious pitfalls which can be encountered in a course of hypertension-
hypervolemia therapy for vasospasm]
VL - 20
ID - 2732
ER -
TY - JOUR
AB - BACKGROUND AND PURPOSE: Stroke is the third leading cause of death in most
Western countries. Cardioembolism might be responsible for 15% to 20% of ischemic
strokes. Although atrial fibrillation can be diagnosed by electrocardiography, the
remaining causes of cardioembolic stroke are diagnosed by echocardiography. Recent
recommendations on the management of acute ischemic stroke fail to consider
echocardiography as an essential test in all patients. METHODS: We conducted a
prospective observational study, performing transthoracic echocardiography on all
patients admitted in our hospital with ischemic stroke, in sinus rhythm, from
January 7, 2002, to October 16, 2003. Findings compatible with heart diseases that
would indicate anticoagulation as beneficial were identified. RESULTS: Of the 853
patients admitted with ischemic stroke, transthoracic echocardiography was
performed on 846 (99.2%). Of the 435 patients with ischemic stroke, in sinus
rhythm, 37.2% had findings indicating anticoagulation as beneficial: dilated
cardiopathy (19.1%), previous anterior wall myocardial infarction (6.2%), left
ventricular systolic dysfunction with an ejection fraction <35% (3.7%), mitral
valve stenosis with enlarged left atria (1.6%), intracardiac masses (0.5%),
valvular prosthesis (0.2%), and >1 abnormality (5.5%). CONCLUSIONS: In our study,
transthoracic echocardiography had therapy implications in 37.2% of ischemic stroke
patients in sinus rhythm. Transthoracic echocardiography should be considered an
essential test in all ischemic stroke patients in sinus rhythm.
AD - Cardiac and Neurologic Ultrassonography Laboratory, Hospital do Espírito
Santo-Evora, Evora, Portugal. ttabreu@clix.pt
AN - 15947277
AU - Abreu, T. T.
AU - Mateus, S.
AU - Correia, J.
DA - Jul
DO - 10.1161/01.Str.0000170636.08554.49
DP - NLM
ET - 2005/06/11
IS - 7
J2 - Stroke
KW - Aged
Aged, 80 and over
Anticoagulants/therapeutic use
Atrial Fibrillation
Cardiomyopathy, Dilated/diagnosis
Echocardiography/*methods
Embolism/*diagnosis/*therapy
Female
Heart Atria/abnormalities
Humans
Ischemia/pathology
Male
Middle Aged
Mitral Valve Stenosis/diagnosis
Myocardial Infarction/diagnosis
Myocardial Ischemia/*diagnosis/*therapy
Stroke/*diagnosis/*therapy
Stroke Volume
Systole
Ventricular Dysfunction, Left/diagnosis
LA - eng
N1 - 1524-4628
Abreu, Tiago Tribolet de
Mateus, Sónia
Correia, José
Journal Article
United States
Stroke. 2005 Jul;36(7):1565-6. doi: 10.1161/01.STR.0000170636.08554.49. Epub 2005
Jun 9.
PY - 2005
SN - 0039-2499
SP - 1565-6
ST - Therapy implications of transthoracic echocardiography in acute ischemic
stroke patients
T2 - Stroke
TI - Therapy implications of transthoracic echocardiography in acute ischemic
stroke patients
VL - 36
ID - 2446
ER -
TY - JOUR
AB - BACKGROUND AND OBJECTIVES: The new oral anticoagulants (NOACs) are used
for the prevention of thromboembolic complications in patients with non-valvular
atrial fibrillation (AF) and those at risk of deep venous thrombosis. Their rapid
onset of action and predictable pharmacokinetic and pharmacodynamic profiles make
them the optimal alternative to warfarin in the treatment of these two categories
of patients. Unfortunately, however, NOACs cannot be used in patients with valvular
AF or valvular cardiac prostheses. Although mechanical valves are effectively a
contraindication to NOAC use due to several pathophysiological mechanisms that
promote the use of warfarin rather than NOACs, few data exist regarding the use of
such new pharmacological compounds on patients with cardiac biological valves or
those who have undergone mitral repair or tubular aortic graft implantation.
METHODS: Our case series involved 27 patients [mean age 70 ± 10 years; mean
CHA2DS2-VASc (Congestive heart failure, Hypertension, Age ≥75 years (doubled),
Diabetes mellitus, Stroke/transient ischemic attack (doubled), Vascular disease,
Age 65-74 years, Sex category): 6 ± 1.4; and mean HAS-BLED (Hypertension, Abnormal
renal and liver function, Stroke, Bleeding, Labile international normalized ratios,
Elderly, Drugs or alcohol): 4 ± 1] with AF and biological prostheses, repaired
mitral valves, or tubular aortic graft who were treated with the factor Xa
inhibitor rivaroxaban due to inefficacy or adverse effects of warfarin. RESULTS:
The mean left ventricular ejection fraction was 48 ± 9 %, the left atrial diameter
was 46.5 ± 7 mm, and the estimated glomerular filtration rate was
45 ± 21 mL/min/1.73 m(2). The mean duration of treatment was 15 ± 2 months. No
relevant complications or recurrent thromboembolic events occurred. Three patients
had recurrent nose bleeding and two had hematuria that led to reduction of the
rivaroxaban dose by the treating physician to 15 mg once a day after 4 months of
therapy. No further bleeding episode was recorded after escalating the dose.
CONCLUSIONS: Rivaroxaban is a valuable treatment option for patients with
biological prostheses, repaired mitral valves, or a tubular aortic graft in order
to prevent thromboembolic complications.
AD - Salvatore Maugeri Foundation I.R.C.C.S., Telese Terme, Benevento, Italy.
Section of Cardiovascular Diseases, Department of Emergency and Organ
Transplantation, School of Medicine, University of Bari, Piazza G. Cesare 11,
70124, Bari, Italy.
San Francesco Hospital, Telese Terme, Benevento, Italy.
Department of Geriatrics, Campus Bio-Medico University, Rome, Italy.
Section of Cardiovascular Diseases, Department of Emergency and Organ
Transplantation, School of Medicine, University of Bari, Piazza G. Cesare 11,
70124, Bari, Italy. marcomatteo.ciccone@uniba.it.
AN - 27401780
AU - Acanfora, D.
AU - Acanfora, C.
AU - Scicchitano, P.
AU - Longobardi, M.
AU - Furgi, G.
AU - Casucci, G.
AU - Lanzillo, B.
AU - Dentamaro, I.
AU - Zito, A.
AU - Incalzi, R. A.
AU - Ciccone, M. M.
DA - Oct
DO - 10.1007/s40261-016-0436-5
DP - NLM
ET - 2016/07/13
IS - 10
J2 - Clinical drug investigation
KW - Aged
Aged, 80 and over
Anticoagulants/*therapeutic use
Atrial Fibrillation/complications
Female
Fibrinolytic Agents/therapeutic use
Heart Failure/physiopathology
Hemorrhage/chemically induced
Humans
Hypertension/drug therapy
International Normalized Ratio
Male
Middle Aged
Rivaroxaban/*therapeutic use
Stroke/*prevention & control
Thromboembolism/*prevention & control
LA - eng
N1 - 1179-1918
Acanfora, Domenico
Acanfora, Chiara
Scicchitano, Pietro
Longobardi, Marialaura
Furgi, Giuseppe
Casucci, Gerardo
Lanzillo, Bernardo
Dentamaro, Ilaria
Zito, Annapaola
Incalzi, Raffaele Antonelli
Ciccone, Marco Matteo
Journal Article
New Zealand
Clin Drug Investig. 2016 Oct;36(10):857-62. doi: 10.1007/s40261-016-0436-5.
PY - 2016
SN - 1173-2563
SP - 857-62
ST - Safety and Feasibility of Treatment with Rivaroxaban for Non-Canonical
Indications: A Case Series Analysis
T2 - Clin Drug Investig
TI - Safety and Feasibility of Treatment with Rivaroxaban for Non-Canonical
Indications: A Case Series Analysis
VL - 36
ID - 2522
ER -
TY - JOUR
AB - BACKGROUND: Cardiovascular disease is the leading cause of pregnancy-related
death in the United States. Identification of short-term indicators of
cardiovascular morbidity has the potential to alter the course of this devastating
disease among women. It has been established that hypertensive disorders of
pregnancy are associated with increased risk of cardiovascular disease 10-30 years
after delivery; however, little is known about the association of hypertensive
disorders of pregnancy with cardiovascular morbidity during the delivery
hospitalization. OBJECTIVE: We aimed to identify the immediate risk of
cardiovascular morbidity during the delivery hospitalization among women who
experienced a hypertensive disorder of pregnancy. MATERIALS AND METHODS: This
retrospective cohort study of women, 15-55 years old with a singleton gestation
between 2008 and 2012 in New York City, examined the risk of severe cardiovascular
morbidity in women with hypertensive disorders of pregnancy compared with
normotensive women during their delivery hospitalization. Women with a history of
chronic hypertension, diabetes mellitus, or cardiovascular disease were excluded.
Mortality and severe cardiovascular morbidity (myocardial infarction,
cerebrovascular disease, acute heart failure, heart failure or arrest during labor
or procedure, cardiomyopathy, cardiac arrest and ventricular fibrillation, or
conversion of cardiac rhythm) during the delivery hospitalization were identified
using birth certificates and discharge record coding. Using multivariable logistic
regression, we assessed the association between hypertensive disorders of pregnancy
and severe cardiovascular morbidity, adjusting for relevant sociodemographic and
pregnancy-specific clinical risk factors. RESULTS: A total of 569,900 women met
inclusion criteria. Of those women, 39,624 (6.9%) had a hypertensive disorder of
pregnancy: 11,301 (1.9%) gestational hypertension; 16,117 (2.8%) preeclampsia
without severe features; and 12,206 (2.1%) preeclampsia with severe features, of
whom 319 (0.06%) had eclampsia. Among women with a hypertensive disorder of
pregnancy, 431 experienced severe cardiovascular morbidity (10.9 per 1000
deliveries; 95% confidence interval, 9.9-11.9). Among normotensive women, 1780
women experienced severe cardiovascular morbidity (3.4 per 1000 deliveries; 95%
confidence interval, 3.2-3.5). Compared with normotensive women, there was a
progressively increased risk of cardiovascular morbidity with gestational
hypertension (adjusted odds ratio, 1.18; 95% confidence interval, 0.92-1.52),
preeclampsia without severe features (adjusted odds ratio, 1.96; 95% confidence
interval, 1.66-2.32), preeclampsia with severe features (adjusted odds ratio, 3.46;
95% confidence interval, 2.99-4.00), and eclampsia (adjusted odds ratio, 12.46; 95%
confidence interval, 7.69-20.22). Of the 39,624 women with hypertensive disorders
of pregnancy, there were 15 maternal deaths, 14 of which involved 1 or more cases
of severe cardiovascular morbidity. CONCLUSION: Hypertensive disorders of
pregnancy, particularly preeclampsia with severe features and eclampsia, are
significantly associated with cardiovascular morbidity during the delivery
hospitalization. Increased vigilance, including diligent screening for cardiac
pathology in patients with hypertensive disorders of pregnancy, may lead to
decreased morbidity for mothers.
AD - Department of Obstetrics, Gynecology, and Reproductive Science, Yale New
Haven Hospital, New Haven, CT. Electronic address: Christina.ackerman@yale.edu.
Department of Gynecology and Obstetrics, Emory University, Atlanta, GA.
Department of Cardiology, Yale New Haven Hospital, New Haven, CT.
Department of Obstetrics, Gynecology, and Reproductive Science, Yale New Haven
Hospital, New Haven, CT.
Department of Obstetrics and Gynecology, Queen's University School of Medicine,
Kingston, ON, Canada.
AN - 30742823
AU - Ackerman, C. M.
AU - Platner, M. H.
AU - Spatz, E. S.
AU - Illuzzi, J. L.
AU - Xu, X.
AU - Campbell, K. H.
AU - Smith, G. N.
AU - Paidas, M. J.
AU - Lipkind, H. S.
DA - Jun
DO - 10.1016/j.ajog.2019.02.010
DP - NLM
ET - 2019/02/12
IS - 6
J2 - American journal of obstetrics and gynecology
KW - Adolescent
Adult
Cardiomyopathies/epidemiology
Cardiovascular Diseases/*epidemiology
Cerebrovascular Disorders/epidemiology
Cohort Studies
Eclampsia/epidemiology
Educational Status
Electric Countershock
Ethnic Groups/statistics & numerical data
Female
Heart Arrest/epidemiology
Heart Failure/epidemiology
*Hospitalization
Humans
Hypertension, Pregnancy-Induced/*epidemiology
Information Storage and Retrieval
Insurance, Health/statistics & numerical data
Logistic Models
Middle Aged
Myocardial Infarction/epidemiology
New York City/epidemiology
Obesity, Maternal/epidemiology
Poverty/statistics & numerical data
Pre-Eclampsia/epidemiology
Pregnancy
Severity of Illness Index
Ventricular Fibrillation/epidemiology
Young Adult
*cardiovascular morbidity
*preeclampsia
*severe maternal morbidity
LA - eng
N1 - 1097-6868
Ackerman, Christina M
Platner, Marissa H
Spatz, Erica S
Illuzzi, Jessica L
Xu, Xiao
Campbell, Katherine H
Smith, Graeme N
Paidas, Michael J
Lipkind, Heather S
Journal Article
United States
Am J Obstet Gynecol. 2019 Jun;220(6):582.e1-582.e11. doi:
10.1016/j.ajog.2019.02.010. Epub 2019 Feb 8.
PY - 2019
SN - 0002-9378
SP - 582.e1-582.e11
ST - Severe cardiovascular morbidity in women with hypertensive diseases during
delivery hospitalization
T2 - Am J Obstet Gynecol
TI - Severe cardiovascular morbidity in women with hypertensive diseases during
delivery hospitalization
VL - 220
ID - 3071
ER -
TY - JOUR
AB - In a number of cardiac conditions (acute myocardial infarction, chronic left
ventricular aneurysm, dilated cardiomyopathy, infective endocarditis and atrial
fibrillation in the absence of valvular disease), the risk of embolism gives cause
for concern. Although anticoagulation with warfarin (Coumadin)-derivatives has been
shown to be effective in some of these situations, there is no evidence regarding
the role of antiplatelet agents. The common factor in the thromboembolic potential
of acute myocardial infarction, chronic left ventricular aneurysm and dilated
cardiomyopathy is mural thrombus. This can be detected by two-dimensional
echocardiography and indium-111 platelet scintigraphy. Although of value in
elucidating the natural history of mural thrombus, in most cases, management is not
substantially aided by these investigations. In patients with extensive myocardial
infarction, particularly anterior infarction, moderate intensity anticoagulation
started soon after hospital admission reduces the rate of embolism. After 8 to 12
weeks, embolic risk is low so that anticoagulants can usually be discontinued.
Patients with chronic left ventricular aneurysm have a low incidence of embolism;
anticoagulation is, therefore, inappropriate. Dilated cardiomyopathy is associated
with a high risk of embolism; moderate intensity anticoagulation may be advisable
in many such cases. Little information is available regarding the incidence of
thromboembolism or the role of antithrombotic therapy in the patient with a
diffusely dilated left ventricle due to ischemic heart disease. In native valve
infective endocarditis, the risk of hemorrhage is high, and the efficacy of
conventional anticoagulants unclear; thus, anticoagulation should not be instituted
for the cardiac condition as such. However, in prosthetic valve endocarditis, the
risk of embolism seems to be very high, and anticoagulant therapy should be
continued, but with great care because there is a substantial risk of cerebral
hemorrhage. Atrial fibrillation in patients with valvular heart disease is dealt
with in a previous review. Patients with nonvalvular atrial fibrillation are at
varying risk of embolism, depending on the etiology of the arrhythmia; trials of
antithrombotic therapy are needed for the various subsets of patients. In most
elderly patients, the etiology is not known, and their stroke risk is high. The
risk of embolism in younger patients with idiopathic atrial fibrillation is so low
as to make any antithrombotic therapy unnecessary.(ABSTRACT TRUNCATED AT 400 WORDS)
AN - 3537072
AU - Adams, P. C.
AU - Cohen, M.
AU - Chesebro, J. H.
AU - Fuster, V.
DA - Dec
DO - 10.1016/s0735-1097(86)80009-2
DP - NLM
ET - 1986/12/01
IS - 6 Suppl B
J2 - Journal of the American College of Cardiology
Cardiomyopathy, Dilated/complications
Endocarditis, Bacterial/complications
Heart Aneurysm/complications
Heart Diseases/*complications
Humans
Thromboembolism/etiology/*prevention & control
LA - eng
N1 - Adams, P C
Cohen, M
Chesebro, J H
Fuster, V
Journal Article
Review
United States
J Am Coll Cardiol. 1986 Dec;8(6 Suppl B):76B-87B. doi: 10.1016/s0735-1097(86)80009-
2.
PY - 1986
SN - 0735-1097 (Print)
0735-1097
SP - 76b-87b
ST - Thrombosis and embolism from cardiac chambers and infected valves
T2 - J Am Coll Cardiol
TI - Thrombosis and embolism from cardiac chambers and infected valves
VL - 8
ID - 2977
ER -
TY - JOUR
AB - BACKGROUND: Africa has a growing burden of stroke with associated high
morbidity and a 3-year fatality rate of 84%. Cardiac disease contributes to stroke
occurrence and outcomes, but the precise relationship of abnormalities as noted on
a cheap and widely available test, the electrocardiogram (ECG), and acute stroke
outcomes have not been previously characterized in Africans. OBJECTIVES: The study
assessed the prevalence and prognoses of various ECG abnormalities among African
acute stroke patients encountered in a multisite, cross-national epidemiologic
study. METHODS: We included 890 patients from Nigeria and Ghana with acute stroke
who had 12-lead ECG recording within first 24 h of admission and stroke classified
based on brain computed tomography scan or magnetic resonance imaging. Stroke
severity at baseline was assessed using the Stroke Levity Scale (SLS), whereas 1-
month outcome was assessed using the modified Rankin Scale (mRS). RESULTS:
Patients' mean age was 58.4 ± 13.4 years, 490 were men (55%) and 400 were women
(45%), 65.5% had ischemic stroke, and 85.4% had at least 1 ECG abnormality. Women
were significantly more likely to have atrial fibrillation, or left ventricular
hypertrophy with or without strain pattern. Compared to ischemic stroke patients,
hemorrhagic stroke patients were less likely to have atrial fibrillation (1.0% vs.
6.7%; p = 0.002), but more likely to have left ventricular hypertrophy (64.4% vs.
51.4%; p = 0.004). Odds of severe disability or death at 1 month were higher with
severe stroke (AOR: 2.25; 95% confidence interval: 1.44 to 3.50), or atrial
enlargement (AOR: 1.45; 95% confidence interval: 1.04 to 2.02). CONCLUSIONS: About
4 in 5 acute stroke patients in this African cohort had evidence of a baseline ECG
abnormality, but presence of any atrial enlargement was the only independent ECG
predictor of death or disability.
AD - University of Ibadan, Ibadan, Nigeria.
Medical University of South Carolina, Charleston, SC, USA.
Federal Medical Centre, Abeokuta, Nigeria.
Ahmadu Bello University, Zaria, Nigeria.
University of Ghana Medical School, Accra, Ghana.
University of Ilorin Teaching Hospital, Ilorin, Nigeria.
Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Federal Medical Center, Umuahia, Nigeria.
Jos University Teaching Hospital, Jos, Nigeria.
Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
Sacred Heart Hospital, Abeokuta, Nigeria.
Federal University Teaching Hospital, Ido-Ekiti, Nigeria.
University of Alabama at Birmingham, Birmingham, AL, USA.
University of Kentucky at Lexington, Lexington, KY, USA.
Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria.
Aminu Kano Teaching Hospital, Kano, Nigeria.
Delta State University Teaching Hospital, Ogara, Nigeria.
Federal Medical Centre, Owo, Nigeria.
University of Ibadan, Ibadan, Nigeria. Electronic address: mayowaowolabi@yahoo.com.
AN - 28302557
AU - Adeoye, A. M.
AU - Ogah, O. S.
AU - Ovbiagele, B.
AU - Akinyemi, R.
AU - Shidali, V.
AU - Agyekum, F.
AU - Aje, A.
AU - Adebayo, O.
AU - Akinyemi, J. O.
AU - Kolo, P.
AU - Appiah, L. T.
AU - Iheonye, H.
AU - Kelechukwu, U.
AU - Ganiyu, A.
AU - Olunuga, T. O.
AU - Akpa, O.
AU - Olagoke, O. O.
AU - Sarfo, F. S.
AU - Wahab, K.
AU - Olowookere, S.
AU - Fakunle, A.
AU - Akpalu, A.
AU - Adebayo, P. B.
AU - Nkromah, K.
AU - Yaria, J.
AU - Ibinaiye, P.
AU - Ogbole, G.
AU - Olumayowa, A.
AU - Lakoh, S.
AU - Calys-Tagoe, B.
AU - Olowoyo, P.
AU - Innocent, C.
AU - Tiwari, H. K.
AU - Arnett, D.
AU - Godwin, O.
AU - Ayotunde, B.
AU - Akpalu, J.
AU - Obiora, O.
AU - Joseph, O.
AU - Omisore, A.
AU - Jenkins, C.
AU - Lackland, D.
AU - Owolabi, L.
AU - Isah, S.
AU - Dambatta, A. H.
AU - Komolafe, M.
AU - Bock-Oruma, A.
AU - Melikam, E. S.
AU - Imoh, L. C.
AU - Sunmonu, T.
AU - Gebregziabher, M.
AU - Olabisi, O.
AU - Armstrong, K.
AU - Onyeonoro, U. U.
AU - Sanya, E.
AU - Agunloye, A. M.
AU - Ogunjimi, L.
AU - Arulogun, O.
AU - Farombi, T. H.
AU - Obiabo, O.
AU - Obiako, R.
AU - Owolabi, M.
C2 - PMC5582979
C6 - NIHMS844241
DA - Jun
DO - 10.1016/j.gheart.2017.01.002
DP - NLM
ET - 2017/03/18
IS - 2
J2 - Global heart
KW - Arrhythmias, Cardiac/complications/physiopathology
Brain/diagnostic imaging
Cardiomyopathy, Hypertrophic/complications/physiopathology
Cross-Sectional Studies
*Electrocardiography
Female
Ghana/epidemiology
Heart Rate/*physiology
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Nigeria/epidemiology
Prevalence
Prognosis
Stroke/*epidemiology/etiology/physiopathology
Survival Rate/trends
Tomography, X-Ray Computed
LA - eng
N1 - 2211-8179
Adeoye, Abiodun M
Ogah, Okechukwu S
Ovbiagele, Bruce
Akinyemi, Rufus
Shidali, Vincent
Agyekum, Francis
Aje, Akinyemi
Adebayo, Oladimeji
Akinyemi, Joshua O
Kolo, Philip
Appiah, Lambert Tetteh
Iheonye, Henry
Kelechukwu, Uwanuruochi
Ganiyu, Amusa
Olunuga, Taiwo O
Akpa, Onoja
Olagoke, Ojo Olakanmi
Sarfo, Fred Stephen
Wahab, Kolawole
Olowookere, Samuel
Fakunle, Adekunle
Akpalu, Albert
Adebayo, Philip B
Nkromah, Kwadwo
Yaria, Joseph
Ibinaiye, Philip
Ogbole, Godwin
Olumayowa, Aridegbe
Lakoh, Sulaiman
Calys-Tagoe, Benedict
Olowoyo, Paul
Innocent, Chukwuonye
Tiwari, Hemant K
Arnett, Donna
Godwin, Osaigbovo
Ayotunde, Bisi
Akpalu, Josephine
Obiora, Okeke
Joseph, Odo
Omisore, Adeleye
Jenkins, Carolyn
Lackland, Daniel
Owolabi, Lukman
Isah, Suleiman
Dambatta, Abdu H
Komolafe, Morenikeji
Bock-Oruma, Andrew
Melikam, Ezinne Sylvia
Imoh, Lucius Chidiebere
Sunmonu, Taofiki
Gebregziabher, Mulugeta
Olabisi, Oluyemisi
Armstrong, Kevin
Onyeonoro, Ugochukwu U
Sanya, Emmanuel
Agunloye, Atinuke M
Ogunjimi, Luqman
Arulogun, Oyedunni
Farombi, Temitope H
Obiabo, Olugbo
Obiako, Reginald
Owolabi, Mayowa
SIREN Team as part of the H3Africa Consortium
D43 TW009140/TW/FIC NIH HHS/United States
U54 HG007479/HG/NHGRI NIH HHS/United States
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Glob Heart. 2017 Jun;12(2):99-105. doi: 10.1016/j.gheart.2017.01.002. Epub 2017 Mar
14.
PY - 2017
SN - 2211-8160 (Print)
2211-8160
SP - 99-105
ST - Prevalence and Prognostic Features of ECG Abnormalities in Acute Stroke:
Findings From the SIREN Study Among Africans
T2 - Glob Heart
TI - Prevalence and Prognostic Features of ECG Abnormalities in Acute Stroke:
Findings From the SIREN Study Among Africans
VL - 12
ID - 2465
ER -
TY - JOUR
AB - PURPOSE: Atrial fibrillation (AF) is commonly associated with structural
heart disease. Although heart failure (HF) has been proposed as a risk factor for
stroke, the coexistence of the 2 diseases increases disproportionally the risk of
thromboembolic events. Our objective was to conduct a systematic review to assess
the effect of HF on the end points of stroke, systemic embolism (SE), or mortality
in patients with AF. METHODS: A literature search was performed to identify studies
that examined stroke/ SE in relation to AF and HF. Overall, 405 articles satisfied
the preinclusion criteria. FINDINGS: In studies in which HF was based on a clinical
diagnosis, HF independently increased stroke/SE in 5 of 13 studies, conferring 1.6-
to 3.1-fold increase in risk. When HF was defined as impaired left ventricular (LV)
function on echocardiography, the additive risk was evident in 4 of 6 studies, with
1.7- to 2.6-fold increase in the risk of stroke/SE. The data about HF with
preserved ejection fraction were less robust, although a recent presentation with
acute decompensated HF increased the risk of stroke/SE, irrespective of ejection
fraction. IMPLICATIONS: LV systolic impairment as identified by echocardiography is
an independent risk factor for stroke/SE, although the magnitude by which it
increases the risk of stroke cannot be precisely quantified. Whether a clinical
diagnosis of HF is a significant risk factor remains inconclusive, although when
the diagnosis is certain (recent decompensation requiring hospitalization), it does
seem to be a significant risk factor irrespective of LV systolic function.
AD - University of Birmingham Centre for Cardiovascular Sciences, City Hospital,
Birmingham, United Kingdom.
University of Birmingham Centre for Cardiovascular Sciences, City Hospital,
Birmingham, United Kingdom. Electronic address: g.y.h.lip@bham.ac.uk.
AN - 25146364
AU - Agarwal, M.
AU - Apostolakis, S.
AU - Lane, D. A.
AU - Lip, G. Y.
DA - Sep 1
DO - 10.1016/j.clinthera.2014.07.015
DP - NLM
ET - 2014/08/26
IS - 9
J2 - Clinical therapeutics
KW - Atrial Fibrillation/*complications/*mortality
Echocardiography
Heart Failure/*complications/diagnostic imaging
Humans
Risk Factors
Stroke/epidemiology/*etiology
Stroke Volume
Thromboembolism/epidemiology/*etiology
Ventricular Dysfunction, Left/*complications/diagnostic imaging
atrial fibrillation
cardiac failure
stroke
thromboembolism
LA - eng
N1 - 1879-114x
Agarwal, Megha
Apostolakis, Stavros
Lane, Deirdre A
Lip, Gregory Y H
Journal Article
Review
Systematic Review
United States
Clin Ther. 2014 Sep 1;36(9):1135-44. doi: 10.1016/j.clinthera.2014.07.015. Epub
2014 Aug 19.
PY - 2014
SN - 0149-2918
SP - 1135-44
ST - The impact of heart failure and left ventricular dysfunction in predicting
stroke, thromboembolism, and mortality in atrial fibrillation patients: a
systematic review
T2 - Clin Ther
TI - The impact of heart failure and left ventricular dysfunction in predicting
stroke, thromboembolism, and mortality in atrial fibrillation patients: a
systematic review
VL - 36
ID - 2399
ER -
TY - JOUR
AB - BACKGROUND AND PURPOSE: Premature ventricular complexes (PVCs) detected from
long-term ECG recordings have been associated with an increased risk of ischemic
stroke. Whether PVCs seen on routine ECG, commonly used in clinical practice, are
associated with an increased risk of ischemic stroke remains unstudied. METHODS:
This analysis included 24 460 participants (aged, 64.5+9.3 years; 55.1% women;
40.0% blacks) from the Reasons for Geographic and Racial Differences in Stroke
(REGARDS) study who were free of stroke at the time of enrollment. PVCs were
ascertained from baseline ECG (2003-2007), and incident stroke cases through 2011
were confirmed by an adjudication committee. RESULTS: A total of 1415 (5.8%)
participants had at least 1 PVC at baseline, and 591 developed incident ischemic
stroke during an average (SD) follow-up of 6.0 (2.0) years. In a cox proportional
hazards model adjusted for age, sex, race, geographic region, education, previous
heart disease, systolic blood pressure, blood pressure-lowering medications,
current smoking, diabetes mellitus, left ventricular hypertrophy by ECG, and
aspirin use and warfarin use, the presence of PVCs was associated with 38%
increased risk of ischemic stroke (hazard ratio [95% confidence interval], 1.38
[1.05-1.81]). CONCLUSIONS: PVCs are common on routine screening ECGs and are
associated with an increased risk of ischemic stroke.
AD - From the Division of Cardiology (S.K.A.) and Department of Internal Medicine
(J.C.), Icahn School of Medicine at Mount Sinai, New York, NY; Department of
Biostatistics (F.P., S.E.J., G.H.) and Department of Epidemiology (V.J.H.), School
of Public Health, University of Alabama at Birmingham; Department of Neurology,
University of Cincannati, OH (B.K., D.K.); and Division of Epidemiology and
Prevention EpiCare, Division of Public Health Sciences, Wake Forest School of
Medicine, Winston Salem, NC (E.Z.S.). sunilagarwal1@gmail.com.
From the Division of Cardiology (S.K.A.) and Department of Internal Medicine
(J.C.), Icahn School of Medicine at Mount Sinai, New York, NY; Department of
Biostatistics (F.P., S.E.J., G.H.) and Department of Epidemiology (V.J.H.), School
of Public Health, University of Alabama at Birmingham; Department of Neurology,
University of Cincannati, OH (B.K., D.K.); and Division of Epidemiology and
Prevention EpiCare, Division of Public Health Sciences, Wake Forest School of
Medicine, Winston Salem, NC (E.Z.S.).
AN - 25873602
AU - Agarwal, S. K.
AU - Chao, J.
AU - Peace, F.
AU - Judd, S. E.
AU - Kissela, B.
AU - Kleindorfer, D.
AU - Howard, V. J.
AU - Howard, G.
AU - Soliman, E. Z.
C2 - PMC4414890
C6 - NIHMS675009
DA - May
DO - 10.1161/strokeaha.114.008447
DP - NLM
ET - 2015/04/16
IS - 5
J2 - Stroke
KW - African Continental Ancestry Group
Aged
Brain Ischemia/diagnosis/epidemiology
Electrocardiography
European Continental Ancestry Group
Female
Follow-Up Studies
Humans
Male
Middle Aged
Risk Factors
Stroke/*diagnosis/epidemiology
Ventricular Premature Complexes/complications/*diagnosis/epidemiology
hypoxia-ischemia, brain
stroke
ventricular premature complexes
LA - eng
N1 - 1524-4628
Agarwal, Sunil K
Chao, Jennifer
Peace, Frederick
Judd, Suzanne E
Kissela, Brett
Kleindorfer, Dawn
Howard, Virginia J
Howard, George
Soliman, Elsayed Z
U01 NS041588/NS/NINDS NIH HHS/United States
UL1 TR000077/TR/NCATS NIH HHS/United States
Journal Article
Stroke. 2015 May;46(5):1365-7. doi: 10.1161/STROKEAHA.114.008447. Epub 2015 Apr 14.
PY - 2015
SN - 0039-2499 (Print)
0039-2499
SP - 1365-7
ST - Premature ventricular complexes on screening electrocardiogram and risk of
ischemic stroke
T2 - Stroke
TI - Premature ventricular complexes on screening electrocardiogram and risk of
ischemic stroke
VL - 46
ID - 2331
ER -
TY - JOUR
AB - BACKGROUND AND PURPOSE: Premature ventricular complexes (PVCs) on a 2-minute
electrocardiogram are a common, largely asymptomatic finding associated with
increased risk of coronary heart disease and death. They may reflect
atherosclerosis or other pathogenic pathways that predispose to arrhythmias and
stroke. METHODS: We conducted a prospective evaluation of the Atherosclerosis Risk
In Communities Study cohort (n=14,783) of middle-aged men and women to assess
whether the presence of PVCs at study baseline (1987 to 1989) influenced the risk
of incident stroke through December 31, 2004. RESULTS: PVCs were seen in 6.1% of
the participants at baseline, and 729 (4.9%) had incident stroke. The unadjusted
cumulative proportion of incident stroke in individuals with any PVC was 6.6%
compared with 4.1% in those without PVC. The unadjusted hazard ratio of incident
stroke in individuals with any PVC compared with those without any PVCs was 1.71
(95% CI, 1.33 to 2.20). Among individuals without hypertension and diabetes at
baseline, PVCs were independently associated with incident stroke (hazard ratio:
1.72; 95% CI: 1.14 to 2.59). Among those with either diabetes or hypertension, the
presence of any PVCs did not increase the risk of stroke. The association was
stronger for noncarotid embolic stroke than for thrombotic stroke and its magnitude
increased with higher frequency of PVCs. CONCLUSIONS: Frequent PVCs are associated
with risk of incident stroke in participants free of hypertension and diabetes.
This suggests that PVCs may contribute to atrioventricular remodeling or may be a
risk marker for incident stroke, particularly embolic stroke.
AD - University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7075, USA.
AN - 20167922
AU - Agarwal, S. K.
AU - Heiss, G.
AU - Rautaharju, P. M.
AU - Shahar, E.
AU - Massing, M. W.
AU - Simpson, R. J., Jr.
C2 - PMC2866170
C6 - NIHMS181225
DA - Apr
DO - 10.1161/strokeaha.109.567800
DP - NLM
ET - 2010/02/20
IS - 4
J2 - Stroke
KW - Atherosclerosis/complications/physiopathology
Electrocardiography
Female
Humans
Interviews as Topic
Male
Middle Aged
Prospective Studies
Risk Factors
Stroke/*etiology/physiopathology
Ventricular Premature Complexes/*complications/physiopathology
LA - eng
N1 - 1524-4628
Agarwal, Sunil K
Heiss, Gerardo
Rautaharju, Pentti M
Shahar, Eyal
Massing, Mark W
Simpson, Ross J Jr
N01HC55020/HL/NHLBI NIH HHS/United States
N01-HC-55022/HC/NHLBI NIH HHS/United States
N01 HC055018/HC/NHLBI NIH HHS/United States
Journal Article
Stroke. 2010 Apr;41(4):588-93. doi: 10.1161/STROKEAHA.109.567800. Epub 2010 Feb 18.
PY - 2010
SN - 0039-2499 (Print)
0039-2499
SP - 588-93
ST - Premature ventricular complexes and the risk of incident stroke: the
Atherosclerosis Risk In Communities (ARIC) Study
T2 - Stroke
TI - Premature ventricular complexes and the risk of incident stroke: the
Atherosclerosis Risk In Communities (ARIC) Study
VL - 41
ID - 2413
ER -
TY - JOUR
AB - In this review, the authors discuss the role of ECG in prediction of stroke.
ECG plays an important role in detection of several stroke risk factors/predictors
including atrial fibrillation and left ventricular hypertrophy; both are components
of the Framingham Stroke Risk Score. Multiple other ECG traits have also emerged as
potential predictors of stroke, namely cardiac electrical/structural remodeling--Q
wave, QRS/QT duration, bundle blocks, P wave duration/amplitude/dispersion, other
waveform angles and slopes; higher automaticity--ectopic beats; and re-entry--
atrial tachyarrhythmia; and higher vulnerability to arrhythmia--heart rate and its
variability. Most of these predictors are not ready for prime time yet; however,
further research focusing on their role in risk stratification and prevention of
stroke may be useful. In this article, the authors discuss the prevalence,
mechanisms and clinical applications of traditional and novel ECG markers in the
prevention and treatment of stroke.
AD - Johns Hopkins University, 2020 E. Monument Street, B321, Baltimore, MD 21224,
USA. sunilagarwal@jhu.edu
AN - 23895029
AU - Agarwal, S. K.
AU - Soliman, E. Z.
DA - Jul
DO - 10.1586/14779072.2013.811980
DP - NLM
ET - 2013/07/31
IS - 7
J2 - Expert review of cardiovascular therapy
Biomarkers/metabolism
Electrocardiography/*methods
Heart Rate
Humans
Hypertrophy, Left Ventricular/complications
Risk Factors
Stroke/*diagnosis/etiology
LA - eng
N1 - 1744-8344
Agarwal, Sunil K
Soliman, Elsayed Z
Journal Article
Review
England
Expert Rev Cardiovasc Ther. 2013 Jul;11(7):853-61. doi:
10.1586/14779072.2013.811980.
PY - 2013
SN - 1477-9072
SP - 853-61
ST - ECG abnormalities and stroke incidence
T2 - Expert Rev Cardiovasc Ther
TI - ECG abnormalities and stroke incidence
VL - 11
ID - 2365
ER -
TY - JOUR
AB - INTRODUCTION: Cardiac manifestations of intracranial subarachnoid hemorrhage
patients include mild electrocardiogram variability, reversible left ventricular
dysfunction (Takotsubo), non-ST elevation myocardial infarction, ST-elevation
myocardial infarction and cardiac arrest, but their clinical relevance is unclear.
The aim of the present study was to categorize the relative frequency of different
cardiac abnormalities in patients with subarachnoid hemorrhage and determine the
influence of each abnormality on outcome. METHODS: A retrospective review of 617
consecutive patients who presented with non-traumatic aneurysmal subarachnoid
hemorrhage at our institution was performed. A cohort of 87 (14.1%) patients who
required concomitantly cardiological evaluation was selected for subgroup
univariate and multi-variable analysis of radiographic, clinical and cardiac data.
RESULTS: Cardiac complications included myocardial infarction arrhythmia and
congestive heart failure in 47%, 63% and 31% of the patients respectively. The
overall mortality of our cohort (23%) was similar to that of national inpatient
databases. In our cohort a high World Federation of Neurosurgical Surgeons grading
scale and a troponin level >1.0 mcg/L were associated with a 33 times and 10 times
higher risk of death respectively. CONCLUSIONS: Among patients suffering from
cardiac events at the time of aneurysmal subarachnoid hemorrhage, those with
myocardial infarction and in particular those with a troponin level greater than
1.0 mcg/L had a 10 times increased risk of death.
AD - Department of Neurosurgery, University of South Florida, Tampa, Florida.
Department of Anesthesia and Intensive Care, San Raffaele Scientific Institute,
Milan, Italy.
Core Biostatistics, University of South Florida, Tampa, Florida.
Department of Surgery, University of South Florida, Tampa, Florida.
Florida Cardiology Institute, Tampa, Florida.
Florida Gulf-to-Bay Anesthesia, Tampa, Florida.
AN - 24364008
AU - Ahmadian, A.
AU - Mizzi, A.
AU - Banasiak, M.
AU - Downes, K.
AU - Camporesi, E. M.
AU - Thompson Sullebarger, J.
AU - Vasan, R.
AU - Mangar, D.
AU - van Loveren, H. R.
AU - Agazzi, S.
C2 - PMC3848675
DP - NLM
ET - 2013/12/24
IS - 3
J2 - Heart, lung and vessels
KW - Mi
Sah
Takotsubo stress cardiomyopathy
arrhythmia
cardiac outcomes
intracranial aneurysm
myocardial Infarction
subarachnoid hemorrhage
LA - eng
N1 - 2283-3420
Ahmadian, A
Mizzi, A
Banasiak, M
Downes, K
Camporesi, E M
Thompson Sullebarger, J
Vasan, R
Mangar, D
van Loveren, H R
Agazzi, S
Journal Article
Heart Lung Vessel. 2013;5(3):168-78.
PY - 2013
SN - 2282-8419 (Print)
2282-8419
SP - 168-78
ST - Cardiac manifestations of subarachnoid hemorrhage
T2 - Heart Lung Vessel
TI - Cardiac manifestations of subarachnoid hemorrhage
VL - 5
ID - 3113
ER -
TY - JOUR
AB - BACKGROUND: Troponin elevation with electrocardiography changes is not
uncommon in patients with acute ischemic stroke; however, it is still unclear
whether the mechanism of these changes is due to cardiac problems or neurally
mediated myocytic damage. Thus, we investigated cardiac and neurological predictors
of troponin elevation in those patients. METHODS AND RESULTS: We retrospectively
analyzed medical data of the prospectively registered ischemic stroke patients on
stroke registry who were admitted and underwent a serum cardiac troponin I and 12-
lead electrocardiography within 24 hours of symptom onset. However, patients with
well-known troponin-elevating comorbidities were excluded from the analysis. Among
1404 ischemic stroke patients, 121 (8.7%) had elevated troponin, which was defined
as more than 0.04 mg/mL. Multivariable analysis identified electrocardiography
abnormalities such as QTc-prolongation (odds ratio [OR]: 1.52, 95% CI: 1.02-2.28),
left ventricular hypertrophy (OR: 2.14, 95% CI 1.43-3.19), Q-wave (OR: 2.53, 95%
CI: 1.48-4.32), and ST elevation (OR: 2.74, 95% CI: 1.12-6.72) as cardiac variables
associated with troponin elevation, and higher National Institutes of Health Stroke
Scale score (OR: 1.04, 95% CI: 1.01-1.07) and insular cortical lesions (OR: 2.78,
95% CI: 1.85-4.19) as neurological variables associated with troponin elevation.
Incidence of troponin elevation as well as QTc-prolongation was increased further
in combination with cardiac and neurological factors. CONCLUSIONS: Certain cardiac
and neurological conditions in acute ischemic stroke may contribute to troponin
elevation. The proposed concept of cardiac vulnerability to cerebrogenic stress can
be a practical interpretation of troponin elevation and electrocardiography
abnormalities in stroke patients.
AD - Department of Neurology, Asan Medical Center, University of Ulsan, College of
Medicine, Seoul, Korea.
Division of Cardiology, Asan Medical Center, University of Ulsan, College of
Medical School, Asan Medical Center, University of Ulsan, College of Medicine,
Seoul, Korea.
Clinical Research Center, Asan Medical Center, University of Ulsan, College of
Department of Neurology, St. Vincent's Hospital, College of Medicine, The Catholic
University of Korea, Suwon, Korea.
Department of Neurology, Veterans Health Service Medical Center, Seoul, South
Korea.
Department of Neurology, Chosun University Hospital, Gwangju, South Korea.
Department of Neurology, Asan Medical Center, University of Ulsan, College of
Medicine, Seoul, Korea sunkwon7@gmail.com.
AN - 27792642
AU - Ahn, S. H.
AU - Kim, Y. H.
AU - Shin, C. H.
AU - Lee, J. S.
AU - Kim, B. J.
AU - Kim, Y. J.
AU - Noh, S. M.
AU - Kim, S. M.
AU - Kang, H. G.
AU - Kang, D. W.
AU - Kim, J. S.
AU - Kwon, S. U.
C2 - PMC5121511
DA - Oct 6
DO - 10.1161/jaha.116.004135
DP - NLM
ET - 2016/10/30
IS - 10
J2 - Journal of the American Heart Association
KW - Adult
Aged
Aged, 80 and over
Arrhythmias, Cardiac/*blood/physiopathology
Brain Ischemia/*blood/physiopathology
Cerebral Cortex/*blood supply
Electrocardiography
Female
Humans
Hypertrophy, Left Ventricular/*blood/physiopathology
Logistic Models
Male
Middle Aged
Odds Ratio
Stroke/*blood/physiopathology
Troponin I/*blood
Young Adult
*cardiac disease
*electrocardiography
*infarction
*insular
*troponin
LA - eng
N1 - 2047-9980
Ahn, Sung-Ho
Kim, Young-Hak
Shin, Chol-Ho
Lee, Ji-Sung
Kim, Bum-Joon
Kim, Yeon-Jung
Noh, Sang-Mi
Kim, Seung-Min
Kang, Hyun-Goo
Kang, Dong-Wha
Kim, Jong S
Kwon, Sun U
Journal Article
J Am Heart Assoc. 2016 Oct 6;5(10):e004135. doi: 10.1161/JAHA.116.004135.
PY - 2016
SN - 2047-9980
ST - Cardiac Vulnerability to Cerebrogenic Stress as a Possible Cause of Troponin
Elevation in Stroke
T2 - J Am Heart Assoc
TI - Cardiac Vulnerability to Cerebrogenic Stress as a Possible Cause of Troponin
Elevation in Stroke
VL - 5
ID - 2507
ER -
TY - JOUR
AB - Some patients with hypertrophic cardiomyopathy (HCM) develop systolic
dysfunction, called the dilated phase of HCM (d-HCM), which is associated with
increased morbidity and mortality. We conducted a retrospective study using an HCM
database to clarify the incidence, clinical characteristics, and long-term outcomes
of d-HCM. We analyzed an HCM cohort consisting of 434 patients (273 with apical HCM
and 161 with non-apical HCM; 18 had obstructive HCM, 16 had dilated HCM, and 127
had other HCM) diagnosed by echocardiography in our hospital between 1991 and 2010.
The follow-up period was 8.4 ± 6.7 years. The mean age at final follow-up was 67 ±
14 years, and 304 patients (70%) were men. The mean age of the 16 d-HCM patients at
the initial visit was 45 ± 17 years, the age at final follow-up was 59 ± 18 years,
and 13 were men. Thirteen d-HCM patients developed atrial fibrillation and six
patients developed ischemic stroke. Twelve d-HCM patients were implanted with
cardiac devices: one pacemaker, nine implantable cardioverter-defibrillators, and
two cardiac resynchronization therapy with defibrillator. Five patients died of
progressive heart failure at the age of 61 ± 23 years. The age at the initial visit
and final follow-up were lower and the NYHA class, brain natriuretic peptide
levels, and left ventricular function at initial evaluation were worse in the d-HCM
group. Univariate analysis demonstrated that a lower age at the initial visit was
associated with d-HCM (hazard ratio 0.955/1 year increase; 95% CI 0.920-0.991, P =
0.015). In our HCM cohort, the incidence of d-HCM was 4%. A high prevalence of
atrial fibrillation and cerebral infarction and poor prognosis were noted in this
group, despite patients undergoing medication and device implantation.
AD - Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.
AN - 30606897
AU - Aizawa, Y.
AU - Tanimoto, Y.
AU - Hirata, Y.
AU - Fujisawa, T.
AU - Fukuoka, R.
AU - Nakajima, K.
AU - Katsumata, Y.
AU - Nishiyama, T.
AU - Kimura, T.
AU - Yuasa, S.
AU - Kohno, T.
AU - Kohsaka, S.
AU - Murata, M.
AU - Maekawa, Y.
AU - Furukawa, Y.
AU - Takatsuki, S.
AU - Fukuda, K.
DA - Dec 25
DO - 10.2302/kjm.2018-0004-OA
DP - NLM
ET - 2019/01/05
IS - 4
J2 - The Keio journal of medicine
KW - Adult
Aged
Aged, 80 and over
Atrial Fibrillation/diagnostic imaging/mortality/*physiopathology/therapy
Biomarkers/blood
Cardiac Resynchronization Therapy/methods
Cardiomyopathy, Dilated/diagnostic imaging/mortality/*physiopathology/therapy
Cardiomyopathy, Hypertrophic/diagnostic imaging/mortality/*physiopathology/therapy
Cardiotonic Agents/therapeutic use
Defibrillators, Implantable
Echocardiography
Female
Follow-Up Studies
Heart Failure/diagnostic imaging/mortality/*physiopathology/therapy
Humans
Incidence
Japan/epidemiology
Male
Middle Aged
Natriuretic Peptide, Brain/blood
Pacemaker, Artificial
Stroke/diagnostic imaging/mortality/*physiopathology/therapy
Survival Analysis
Ventricular Function, Left/physiology
dilated phase
hypertrophic cardiomyopathy
prognosis
systolic dysfunction
LA - eng
N1 - 1880-1293
Aizawa, Yoshiyasu
Tanimoto, Yoko
Hirata, Yoshiko
Fujisawa, Taishi
Fukuoka, Ryoma
Nakajima, Kazuaki
Katsumata, Yoshinori
Nishiyama, Takahiko
Kimura, Takehiro
Yuasa, Shinsuke
Kohno, Takashi
Kohsaka, Shun
Murata, Mitsushige
Maekawa, Yuichiro
Furukawa, Yoshiko
Takatsuki, Seiji
Fukuda, Keiichi
Journal Article
Japan
Keio J Med. 2019 Dec 25;68(4):87-94. doi: 10.2302/kjm.2018-0004-OA. Epub 2018 Dec
29.
PY - 2019
SN - 0022-9717
SP - 87-94
ST - Incidence, Clinical Characteristics, and Long-term Outcome of the Dilated
Phase of Hypertrophic Cardiomyopathy
T2 - Keio J Med
TI - Incidence, Clinical Characteristics, and Long-term Outcome of the Dilated
Phase of Hypertrophic Cardiomyopathy
VL - 68
ID - 2369
ER -
TY - JOUR
AB - Effect of atrial fibrillation (AF) on short- and long-term outcomes in heart
failure (HF) is controversial. Accordingly, we examined this relationship in a
national multicenter project using data from the Hearts Function Assessment
Registry Trial in Saudi Arabia that studied the clinical features and outcomes of
patients admitted with de novo and acute on chronic HF. Out of 2593 patients with
HF, 449 (17.8%) had AF at presentation. Patients with AF were more likely to be
males and older (mean age 65.2 ± 15.0 vs 60.5 ± 14.8 years) to have a history of
ventricular tachycardia/ventricular fibrillation (3.1% vs 1.9%) or cerebrovascular
accident (15.0% vs 8.5%). However, they were less likely to have diabetes (66.0% vs
55.9%) or coronary artery disease (55.6% vs 42.3%). The 1-, 2-, and 3-year crude
mortality rates were significantly higher in patients with AF (23.2% vs 18.3%,
27.4% vs 22.3%, and 27.8% vs 23.2%, respectively). However, there was no
significant difference in mortality after adjusting for covariates. Thus, in
patients admitted with HF, AF upon presentation was not associated with increased
mortality.
AD - 1 King Fahad Cardiac Center, Department of Cardiac Sciences, College of
Medicine, King Saud University, Riyadh, Saudi Arabia.
2 Prince Salman Heart Center, King Fahad Medical City, Riyadh, Saudi Arabia.
3 Cardiology Department, Tanta University, Egypt.
4 North West Armed Forces Hospital, Tabuk, Saudi Arabia.
5 King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
6 Prince Sultan Cardiac Center, Riyadh, Saudi Arabia.
7 Madina Cardiac Center, Al Madina Al Monaoarah, Saudi Arabia.
8 King Saud Medical Complex, Riyadh, Saudi Arabia.
9 Al-Eman Hospital, Riyadh, Saudi Arabia.
10 King Fahad General Hospital, Jeddah, Saudi Arabia.
11 King Fahad Hospital, Baha, Saudi Arabia.
12 Prince Sultan Cardiac Center, Hafouf, Saudi Arabia.
13 Armed Forces Hospital Southern Region, Khamis Mushayt, Saudi Arabia.
14 National Guard Hospital, Jeddah, Saudi Arabia.
AN - 28592150
AU - Ajlan, M.
AU - Almazroa, L.
AU - AlHabib, K. F.
AU - Elasfar, A. A.
AU - Alfaleh, H.
AU - Albackr, H.
AU - Kashour, T.
AU - Hersi, A.
AU - Hussein, G. A.
AU - Mimish, L.
AU - Almasood, A.
AU - AlHabeeb, W.
AU - AlGhamdi, S.
AU - Alsharari, M.
AU - Chakra, E.
AU - Malik, A.
AU - Soomro, R.
AU - Ghabashi, A.
AU - Al-Murayeh, M.
AU - Abuosa, A.
DA - Feb
DO - 10.1177/0003319717711764
DP - NLM
ET - 2017/06/09
IS - 2
J2 - Angiology
KW - Aged
Atrial Fibrillation/complications/*epidemiology/mortality
Coronary Artery Disease/complications/epidemiology/mortality
Female
Heart Failure/complications/*epidemiology/mortality
Hospitalization/statistics & numerical data
Humans
Male
Middle Aged
Registries/statistics & numerical data
Saudi Arabia
Stroke/complications/epidemiology/mortality
atrial fibrillation
heart failure
long-term outcomes
LA - eng
N1 - 1940-1574
Ajlan, M
Almazroa, L
AlHabib, Khalid F
Elasfar, Abdelfatah A
Alfaleh, Hussam
Albackr, Hanan
Kashour, Tarek
Hersi, Ahmad
Orcid: 0000-0001-5991-5318
Hussein, Gamal A
Mimish, Layth
Almasood, Ali
AlHabeeb, Waleed
AlGhamdi, Saleh
Alsharari, Mubrouk
Chakra, Esmail
Malik, Asif
Soomro, Raza
Ghabashi, Abdullah
Al-Murayeh, Mushabab
Abuosa, Ahmed
Journal Article
United States
Angiology. 2018 Feb;69(2):151-157. doi: 10.1177/0003319717711764. Epub 2017 Jun 8.
PY - 2018
SN - 0003-3197
SP - 151-157
ST - Atrial Fibrillation in Patients Hospitalized With Heart Failure: Patient
Characteristics and Outcomes From the HEARTS Registry
T2 - Angiology
TI - Atrial Fibrillation in Patients Hospitalized With Heart Failure: Patient
Characteristics and Outcomes From the HEARTS Registry
VL - 69
ID - 2438
ER -
TY - JOUR
AB - AIM: Breath-holding spells are common in infancy and early childhood, and
patients are frequently referred to paediatric cardiology clinics for exclusion of
heart disease. Recent data reveal subsequent development of epilepsy and
neurocardiogenic syncope. Autonomic dysregulation and increased vagal stimulation
leading to cardiac arrest and cerebral ischaemia is considered as the cause. Iron
deficiency anaemia may be associated with these spells. We studied QT dispersion
for the assessment of ventricular repolarization in these patients. METHODS: The
study group consisted of 19 girls and 24 boys between 3 and 108 mo of age (mean +/-
SD = 22.7 +/- 17.7 mo); and the control group consisted of 13 girls and 12 boys
between 3 and 57 mo of age (mean +/- SD = 22.9 +/- 15.1 mo). QT interval was
measured; corrected QT interval (QTc), QT dispersion (QTd) and QTc dispersion
(QTcd) were calculated from 12-lead surface electrocardiograms of the patients and
the control group. RESULTS: There was no statistically significant difference in
terms of QT and QTc intervals between patient and control groups, while QTd and
QTcd values were significantly increased in patients with breath-holding spells
compared to the healthy children. QT dispersion was 59.5 +/- 35.9 ms and 44.8 +/-
11.9 ms, respectively, in patients and controls (p < 0.05). QTc dispersion was
102.1 +/- 41.9 ms and 79.6 +/- 24.6 ms, respectively (p < 0.01). The presence of
iron deficiency did not effect the QT and QTc dispersion. CONCLUSION: QT dispersion
is increased in patients with breath-holding spells, and this finding justifies
further investigation for rhythm abnormalities and autonomic dysfunction in this
patient group.
AD - Faculty of Medicine, Marmara University, Istanbul, Turkey.
figenakalin@superonline.com
AN - 15244225
AU - Akalin, F.
AU - Turan, S.
AU - Güran, T.
AU - Ayabakan, C.
AU - Yilmaz, Y.
DA - Jun
DP - NLM
ET - 2004/07/13
IS - 6
J2 - Acta paediatrica (Oslo, Norway : 1992)
KW - Arrhythmias, Cardiac/diagnosis/*etiology/physiopathology
Child, Preschool
*Crying
Electrocardiography
Humans
Infant
Iron/*deficiency
*Respiration
Syncope/diagnosis/*etiology/physiopathology
LA - eng
N1 - Akalin, F
Turan, S
Güran, T
Ayabakan, C
Yilmaz, Y
Journal Article
Norway
Acta Paediatr. 2004 Jun;93(6):770-4.
PY - 2004
SN - 0803-5253 (Print)
0803-5253
SP - 770-4
ST - Increased QT dispersion in breath-holding spells
T2 - Acta Paediatr
TI - Increased QT dispersion in breath-holding spells
VL - 93
ID - 2814
ER -
TY - JOUR
AB - In the present study, Holter ECG (24 hours continuous monitoring) was applied
for detection of arrhythmia in patients with cerebral infarction to elucidate the
relationship between arrhythmias and types of cerebral infarction. The subjects
were 111 patients (80 males and 31 females) with cerebral infarction who were
admitted to our institution during the acute stage. Their average age was 65.4
years old. They were divided into the following three groups: Group L; patients
having a large low density area on CT including the cortex, group S; those having a
small low density area in the basal ganglia, and group N; those having no low
density area on CT. Holter ECG was taken at least three weeks after onset in all
cases. Fourteen of them were also examined in the acute stage, and these findings
were compared with those taken in the chronic stage. Three Holter ECGs recorded
incidentally before the onset of stroke were used for comparison. Based on the
basic rhythms recorded on the Holter ECG, the subjects were divided into sinus
rhythm and atrial fibrillation cases. The total number of ventricular premature
contractions (VPCs), were determined in each case. There was little difference in
the number of total VPCs among the records taken in the pre-onset, acute and
chronic stages. There also was no relation between the total number of VPCs and the
age, history of hypertension, and the site of infarction on CT. There was no
consistent relationship between the total number of VPCs in cases with atrial
fibrillation and CT findings.(ABSTRACT TRUNCATED AT 250 WORDS)
AN - 2795966
AU - Akashi, N.
DA - Mar
DO - 10.3143/geriatrics.26.153
DP - NLM
ET - 1989/03/01
IS - 2
J2 - Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics
KW - Aged
Arrhythmias, Cardiac/etiology/*physiopathology
Cerebral Infarction/*complications
Female
Humans
Male
Middle Aged
Monitoring, Physiologic
LA - jpn
N1 - Akashi, N
English Abstract
Journal Article
Japan
Nihon Ronen Igakkai Zasshi. 1989 Mar;26(2):153-9. doi: 10.3143/geriatrics.26.153.
PY - 1989
SN - 0300-9173 (Print)
0300-9173
SP - 153-9
ST - [Arrhythmia in patients with cerebral infarction evaluated by Holter ECG]
T2 - Nihon Ronen Igakkai Zasshi
TI - [Arrhythmia in patients with cerebral infarction evaluated by Holter ECG]
VL - 26
ID - 2625
ER -
TY - JOUR
AB - INTRODUCTION: Metabolic syndrome (MetS) is defined as an association between
diabetes, hypertension, obesity and dyslipidemia and an increased risk of
cardiovascular disease. Mitral annular calcification (MAC) is associated with
several cardiovascular disorders, including coronary artery disease, atrial
fibrillation (AF), heart failure, ischemic stroke and increased mortality. The
CHA2DS2-VASc score is used to estimate thromboembolic risk in AF. However, the
association among MAC, MetS and thromboembolic risk is unknown and was evaluated in
the current study. METHODS: The study group consisted of 94 patients with MAC and
86 patients with MetS. Patients were divided into two groups: those with and those
without MAC. RESULTS: Patients with MAC had a higher MetS rate (P<0.001). In
patients with MAC, the CHA2DS2-VASc scores and the rate of cerebrovascular accident
and AF were significantly higher compared to those without MAC (P<0.001, for both
parameters). The results of the multivariate regression analysis showed that
history of smoking, presence of MetS and high CHA2DS2-VASc scores were associated
with the development of MAC. ROC curve analyses showed that CHA2DS2-VASc scores
were significant predictors for MAC (C-statistic: 0.78; 95% CI: 0.706-0.855,
P<0.001). Correlation analysis indicated that MAC was positively correlated with
the presence of MetS and CHA2DS2-VASc score (P=0.001, r=0.264; P<0.001, r=0.490).
CONCLUSION: We have shown that CHA2DS2-VASc score and presence of MetS rates were
significantly higher in patients with MAC compared without MAC. Presence of MAC was
correlated with CHA2DS2-VASc score, presence of MetS, AF and left atrial diameter
and negatively correlated with left ventricular ejection fraction.
AD - Suleyman Demirel University Medical School Department of Cardiology Isparta
Turkey Department of Cardiology, Suleyman Demirel University, Medical School,
Isparta, Turkey.
Suleyman Demirel University Medical School Department of Cardiovascular Surgery
Isparta Turkey Department of Cardiovascular Surgery, Suleyman Demirel University,
Medical School, Isparta, Turkey.
AN - 31719007
AU - Aksoy, F.
AU - Guler, S.
AU - Kahraman, F.
AU - Kuyumcu, M. S.
AU - Bagcı, A.
AU - Bas, H. A.
AU - Uysal, D.
AU - Varol, E.
C2 - PMC6852443
DA - Dec 1
DO - 10.21470/1678-9741-2019-0062
DP - NLM
ET - 2019/11/14
IS - 5
J2 - Brazilian journal of cardiovascular surgery
KW - Aged
Aged, 80 and over
Atrial Fibrillation/physiopathology
Calcinosis/*complications/physiopathology
Echocardiography
Female
Heart Valve Diseases/*complications/physiopathology
Humans
Logistic Models
Male
Metabolic Syndrome/*complications/physiopathology
Middle Aged
*Mitral Valve/physiopathology
Prospective Studies
Risk Assessment/methods
Risk Factors
Sensitivity and Specificity
Stroke Volume/physiology
Thromboembolism/*etiology/physiopathology
*Atrial Fibrilation
*Brain Ischemia
*Coronary Artery Disease
*Hypertension
*Metabolic Syndrome
*Stroke
*Thromboembolism
LA - eng
N1 - 1678-9741
Aksoy, Fatih
Guler, Serdar
Kahraman, Fatih
Kuyumcu, Mevlüt Serdar
Bagcı, Ali
Bas, Hasan Aydın
Uysal, Dinçer
Varol, Ercan
Journal Article
Braz J Cardiovasc Surg. 2019 Dec 1;34(5):535-541. doi: 10.21470/1678-9741-2019-
0062.
PY - 2019
SN - 0102-7638 (Print)
0102-7638
SP - 535-541
ST - The Relationship Between Mitral Annular Calcification, Metabolic Syndrome and
Thromboembolic Risk
T2 - Braz J Cardiovasc Surg
TI - The Relationship Between Mitral Annular Calcification, Metabolic Syndrome and
Thromboembolic Risk
VL - 34
ID - 3052
ER -
TY - JOUR
AB - PURPOSE: Neuronal system activity plays an important role for the prognosis
of patients with atrial fibrillation (AF). Using (123)I metaiodobenzylguanidine
((123)I-MIBG) scintigraphy, we investigated whether a cardiac sympathetic nervous
system (SNS) abnormality would be associated with an increased risk of vascular
events in patients with paroxysmal AF. METHODS: (123)I-MIBG scintigraphy was
performed in 69 consecutive patients (67 + or - 13 years, 62% men) with paroxysmal
AF who did not have structural heart disease. SNS integrity was assessed from the
heart to mediastinum (H/M) ratio on delayed imaging. Serum concentration of C-
reactive protein (CRP) was measured before (123)I-MIBG study. RESULTS: During a
mean of 4.5 + or - 3.6 years follow-up, 19 patients had myocardial infarction,
stroke or heart failure (range: 0.2-11.5 years). SNS abnormality (H/M ratio <2.7)
and high CRP (> or = 0.3 mg/dl) were associated with the vascular events (58.3% in
14 of 24 patients with SNS abnormality vs 11.1% in 5 of 45 patients without SNS
abnormality, p < 0.0001, 52.4% in 11 of 21 patients with high CRP vs 16.7% in 8 of
48 patients without high CRP, p < 0.0001). After adjustment for potential
confounding variables such as age, left atrial dimension and left ventricular
function, SNS abnormality was an independent predictor of vascular events with a
hazard ratio of 4.1 [95% confidence interval (CI): 1.3-12.6, p = 0.014]. Further,
SNS abnormality had an incremental and additive prognostic power in combination
with high CRP with an adjusted hazard ratio of 4.1 (95% CI: 1.5-10.9, p = 0.006).
CONCLUSION: SNS abnormality is predictive of vascular events in patients with
idiopathic paroxysmal AF.
AD - Division of Cardiology, Department of Medicine, Showa University School of
Medicine, 1-5-8 Hatanodai, Shinagawaku, Tokyo 142-8666, Japan.
hzn01233@s02.itscom.net
AN - 20016894
AU - Akutsu, Y.
AU - Kaneko, K.
AU - Kodama, Y.
AU - Li, H. L.
AU - Suyama, J.
AU - Shinozuka, A.
AU - Gokan, T.
AU - Kawamura, M.
AU - Asano, T.
AU - Hamazaki, Y.
AU - Tanno, K.
AU - Kobayashi, Y.
DA - Apr
DO - 10.1007/s00259-009-1322-7
DP - NLM
ET - 2009/12/18
IS - 4
J2 - European journal of nuclear medicine and molecular imaging
KW - *3-Iodobenzylguanidine
Aged
Aged, 80 and over
Atrial Fibrillation/blood/etiology/*physiopathology
C-Reactive Protein/analysis
Disease-Free Survival
Female
Follow-Up Studies
Heart Failure/*epidemiology
Humans
*Iodine Radioisotopes
Japan/epidemiology
Male
Middle Aged
Myocardial Infarction/*epidemiology/etiology
Prognosis
Prospective Studies
*Radiopharmaceuticals
Risk
Stroke/*epidemiology/etiology
Sympathetic Nervous System/*physiopathology
LA - eng
N1 - 1619-7089
Akutsu, Yasushi
Kaneko, Kyouichi
Kodama, Yusuke
Li, Hui-Ling
Suyama, Jumpei
Shinozuka, Akira
Gokan, Takehiko
Kawamura, Mitsuharu
Asano, Taku
Hamazaki, Yuji
Tanno, Kaoru
Kobayashi, Youichi
Journal Article
Germany
Eur J Nucl Med Mol Imaging. 2010 Apr;37(4):742-9. doi: 10.1007/s00259-009-1322-7.
Epub 2009 Dec 17.
PY - 2010
SN - 1619-7070
SP - 742-9
ST - Significance of cardiac sympathetic nervous system abnormality for predicting
vascular events in patients with idiopathic paroxysmal atrial fibrillation
T2 - Eur J Nucl Med Mol Imaging
TI - Significance of cardiac sympathetic nervous system abnormality for predicting
vascular events in patients with idiopathic paroxysmal atrial fibrillation
VL - 37
ID - 2667
ER -
TY - JOUR
AB - BACKGROUND: The khat plant is a stimulant similar to amphetamine and is
thought to induce coronary artery spasm. Khat is widely chewed by individuals
originating from the Horn of Africa and the Arabian Peninsula. The aim of this
study was to evaluate the clinical characteristics and outcome of khat chewers
presenting with acute coronary syndrome. METHODS AND RESULTS: From October 1, 2008,
through June, 30, 2009, 7399 consecutive patients with acute coronary syndrome were
enrolled in the Second Gulf Registry of Acute Coronary Events (Gulf RACE-2).
Nineteen percent of patients were khat chewers; 81% were not. Khat chewers were
older, more often male, and less likely to have cardiovascular risk factors. Khat
chewers were less likely to have a history of coronary artery disease and more
likely to present late and to have higher heart rate and advanced Killip class on
admission. Khat chewers were more likely to present with ST-segment-elevation
myocardial infarction. Overall, khat chewers had higher risk of death, recurrent
myocardial ischemia, cardiogenic shock, ventricular arrhythmia, and stroke compared
with non-khat chewers. After adjustment for baseline variability, khat chewing was
found to be an independent risk factor of death and for recurrent ischemia, heart
failure, and stroke. CONCLUSIONS: Our data confirm earlier observations of worse
in-hospital outcome among acute coronary syndrome patients who chew khat. This
worse outcome persists up to 1 year from the index event. This observational report
underscores the importance of improving education concerning the cardiovascular
risks of khat chewing.
AD - Department of Cardiology, Hamad Medical Corp, Qatar.
AN - 22155995
AU - Ali, W. M.
AU - Al Habib, K. F.
AU - Al-Motarreb, A.
AU - Singh, R.
AU - Hersi, A.
AU - Al Faleh, H.
AU - Asaad, N.
AU - Al Saif, S.
AU - Almahmeed, W.
AU - Sulaiman, K.
AU - Amin, H.
AU - Al-Lawati, J.
AU - Al Bustani, N.
AU - Al-Sagheer, N. Q.
AU - Al-Qahtani, A.
AU - Al Suwaidi, J.
DA - Dec 13
DP - NLM
ET - 2011/12/14
IS - 24
J2 - Circulation
KW - Acute Coronary Syndrome/*epidemiology/ethnology/*mortality
Adult
Aged
Amphetamine/*adverse effects
Catha/*adverse effects
Female
Heart Failure/epidemiology/mortality
Humans
Incidence
Male
Middle Aged
Middle East/epidemiology
Myocardial Ischemia/epidemiology/mortality
Plant Preparations/*adverse effects
Prospective Studies
Registries
Risk Factors
Stroke/epidemiology/mortality
Survival Rate
LA - eng
N1 - 1524-4539
Ali, Waleed M
Al Habib, K F
Al-Motarreb, Ahmed
Singh, Rajvir
Hersi, Ahmad
Al Faleh, Hussam
Asaad, Nidal
Al Saif, Shukri
Almahmeed, Wael
Sulaiman, Kadhim
Amin, Haitham
Al-Lawati, Jawad
Al Bustani, Nizar
Al-Sagheer, Norah Q
Al-Qahtani, Awad
Al Suwaidi, Jassim
Journal Article
Multicenter Study
United States
Circulation. 2011 Dec 13;124(24):2681-9. doi: 10.1161/CIRCULATIONAHA.111.039768.
PY - 2011
SN - 0009-7322
SP - 2681-9
ST - Acute coronary syndrome and khat herbal amphetamine use: an observational
report
T2 - Circulation
TI - Acute coronary syndrome and khat herbal amphetamine use: an observational
report
VL - 124
ID - 2913
ER -
TY - JOUR
AB - INTRODUCTION: Atrial fibrillation and atrial flutter account for one third of
hospitalizations due to arrhythmias, determining great social and economic impacts.
In Brazil, data on hospital care of these patients is scarce. OBJECTIVE: To
investigate the arrhythmia subtype of atrial fibrillation and flutter patients in
the emergency setting and compare the clinical profile, thromboembolic risk and
anticoagulants use. METHODS: Cross-sectional retrospective study, with data
collection from medical records of every patient treated for atrial fibrillation
and flutter in the emergency department of Instituto de Cardiologia do Rio Grande
do Sul during the first trimester of 2012. RESULTS: We included 407 patients (356
had atrial fibrillation and 51 had flutter). Patients with paroxysmal atrial
fibrillation were in average 5 years younger than those with persistent atrial
fibrillation. Compared to paroxysmal atrial fibrillation patients, those with
persistent atrial fibrillation and flutter had larger atrial diameter (48.6 ± 7.2
vs. 47.2 ± 6.2 vs. 42.3 ± 6.4; p < 0.01) and lower left ventricular ejection
fraction (66.8 ± 11 vs. 53.9 ± 17 vs. 57.4 ± 16; p < 0.01). The prevalence of
stroke and heart failure was higher in persistent atrial fibrillation and flutter
patients. Those with paroxysmal atrial fibrillation and flutter had higher
prevalence of CHADS2 score of zero when compared to those with persistent atrial
fibrillation (27.8% vs. 18% vs. 4.9%; p < 0.01). The prevalence of anticoagulation
in patients with CHA2DS2-Vasc ≤ 2 was 40%. CONCLUSIONS: The population in our
registry was similar in its comorbidities and demographic profile to those of North
American and European registries. Despite the high thromboembolic risk, the use of
anticoagulants was low, revealing difficulties for incorporating guideline
recommendations. Public health strategies should be adopted in order to improve
these rates.
AD - Fundação Universitária de Cardiologia, Instituto de Cardiologia do Rio Grande
do Sul, Porto Alegre, RS, BR.
AN - 26016782
AU - Almeida, E. D.
AU - Guimarães, R. B.
AU - Stephan, L. S.
AU - Medeiros, A. K.
AU - Foltz, K.
AU - Santanna, R. T.
AU - Pires, L. M.
AU - Kruse, M. L.
AU - Lima, G. G.
AU - Leiria, T. L.
C2 - PMC4523282 article was reported.
DA - Jul
DO - 10.5935/abc.20150049
DP - NLM
ET - 2015/05/29
IS - 1
J2 - Arquivos brasileiros de cardiologia
KW - Age Factors
Aged
Aged, 80 and over
Atrial Fibrillation/epidemiology/*physiopathology
Atrial Flutter/epidemiology/*physiopathology
Brazil/epidemiology
Comorbidity
Epidemiologic Methods
Female
Humans
Male
Middle Aged
Reference Values
Risk Factors
Sex Factors
Stroke/etiology/prevention & control
Thromboembolism/etiology/prevention & control
LA - eng
por
N1 - 1678-4170
Almeida, Eduardo Dytz
Guimarães, Raphael Boesche
Stephan, Laura Siga
Medeiros, Alexandre Kreling
Foltz, Katia
Santanna, Roberto Tofani
Pires, Leonardo Martins
Kruse, Marcelo Lapa
Lima, Gustavo Glotz de
Leiria, Tiago Luiz Luz
Comparative Study
Journal Article
Arq Bras Cardiol. 2015 Jul;105(1):3-10. doi: 10.5935/abc.20150049. Epub 2015 May
19.
PY - 2015
SN - 0066-782X (Print)
0066-782x
SP - 3-10
ST - Clinical Differences between Subtypes of Atrial Fibrillation and Flutter:
Cross-Sectional Registry of 407 Patients
T2 - Arq Bras Cardiol
TI - Clinical Differences between Subtypes of Atrial Fibrillation and Flutter:
Cross-Sectional Registry of 407 Patients
VL - 105
ID - 2498
ER -
TY - JOUR
AB - BACKGROUND: A variety of ECG changes occur as an aftermath of stroke.
Prolongation of the QTc interval is a well-documented change. We analyzed QTc
interval prolongation among patients with acute hemorrhagic strokes. METHODS: This
observational study was conducted at the Emergency Department of Sulaymaniyah
General Teaching Hospital and Shar Hospital from September 1(st), 2014 to August
31(st), 2015. Fifty patients who developed acute spontaneous hypertensive
intracerebral hemorrhage (ICH) and 50 patients who developed acute non-traumatic
subarachnoid hemorrhage (SAH) were included in the study. All patients underwent
resting 12-lead ECG within half an hour of admission. The QTc interval was
calculated and analyzed in those 100 patients. RESULTS: Females (62%) outnumbered
males (38%) with a female to male ratio of 1.6:1. Forty percent of the patients
were between 60-69 years of age. Hypertension was seen in 82% of patients while
left ventricular hypertrophy was documented in 40% of patients. The QTc was
prolonged in 38 patients (17 patients in the ICH group and 21 patients in the SAH
group). In both groups, males demonstrated QTc prolongation more than females.
However, there were no statistically significant gender difference between both
groups and within the same group. There was a statistically significant association
between SAH and QTc prolongation (p-value<0.001); the ICH group did not demonstrate
any significant relationship with QTc prolongation. CONCLUSION: Prolongation in the
QTc interval was "statistically" associated with acute SAH only. No gender
difference was noted; whether this observation is clinically significant or not, it
needs further analytic studies.
AD - Department of Medicine, School of Medicine, International Medical University,
Malaysia.
Department of Neurology, Shar Hospital, Iraq.
AN - 28974832
AU - Amin, O. S. M.
AU - Al-Bajalan, S. J.
AU - Mubarak, A.
C2 - PMC5585806
DA - Jun
DO - 10.5455/medarh.2017.71.193-197
DP - NLM
ET - 2017/10/05
IS - 3
J2 - Medical archives (Sarajevo, Bosnia and Herzegovina)
KW - Aged
Cerebral Hemorrhage/*complications
Echocardiography
Electrocardiography
Female
Humans
Hypertension/complications
Long QT Syndrome/*etiology
Male
Middle Aged
Sex Distribution
Stroke/*complications
Subarachnoid Hemorrhage/*complications
Ecg
QTc interval prolongation
intracerebral hemorrhage
stroke
LA - eng
N1 - 1986-5961
Amin, Osama Shukir Muhammed
Al-Bajalan, Sarwer Jamal
Mubarak, Alaa
Journal Article
Multicenter Study
Observational Study
Med Arch. 2017 Jun;71(3):193-197. doi: 10.5455/medarh.2017.71.193-197.
PY - 2017
SN - 0350-199X (Print)
0350-199x
SP - 193-197
ST - QTc Interval Prolongation and Hemorrhagic Stroke: Any Difference Between
Acute Spontaneous Intracerebral Hemorrhage and Acute Non-traumatic Subarachnoid
Hemorrhage?
T2 - Med Arch
TI - QTc Interval Prolongation and Hemorrhagic Stroke: Any Difference Between
Acute Spontaneous Intracerebral Hemorrhage and Acute Non-traumatic Subarachnoid
Hemorrhage?
VL - 71
ID - 2428
ER -
TY - JOUR
AB - Anticoagulation with warfarin is the most effective means of reducing stroke
in AF. The generally recommended INR goal is 2-3. Aspirin provides a modest degree
of stroke protection in AF but is inferior to warfarin. Assessment of stroke risk
is critical in determining whether to prescribe warfarin therapy to a patient with
AF. The most important risk factors for stroke in AF are age over 65 years,
hypertension, prior stroke, and left ventricular dysfunction or heart failure. The
risk of warfarin may be less than commonly believed, but increases when warfarin is
combined with aspirin. Patients with paroxysmal AF are not at lower risk of stroke
than those with persistent AF and should be treated with warfarin. Apparently
successful therapy with antiarrhythmic agents does not eliminate the need for
anticoagulation. New antithrombotic therapies are being studied and may soon
provide an alternative to warfarin.
AD - Rhode Island Hospital/Brown Medical School, USA.
AN - 15168633
AU - Anderson, M.
AU - Kirk, M.
DA - Apr
DP - NLM
ET - 2004/06/01
IS - 4
J2 - Medicine and health, Rhode Island
Atrial Fibrillation/*drug therapy
Azetidines/therapeutic use
Benzylamines
Fibrinolytic Agents/*therapeutic use
Humans
Prodrugs/therapeutic use
Warfarin/*therapeutic use
LA - eng
N1 - Anderson, Maria
Kirk, Malcolm
Journal Article
United States
Med Health R I. 2004 Apr;87(4):98-100.
PY - 2004
SN - 1086-5462 (Print)
1086-5462
SP - 98-100
ST - Anticoagulation in atrial fibrillation
T2 - Med Health R I
TI - Anticoagulation in atrial fibrillation
VL - 87
ID - 2562
ER -
TY - JOUR
AB - BACKGROUND: Metabolic syndrome (MetS) is frequently associated with coronary
artery disease, but data on the impact of MetS on long-term outcome of patients
undergoing coronary artery bypass grafting are still lacking. The aim of the
present study was to assess the effect of MetS on mortality and morbidity late
after coronary artery bypass grafting. METHODS: A total of 1,726 consecutive
patients who had elective coronary artery bypass grafting were retrospectively
reviewed and clinical follow-up was completed (mean follow-up time, 34.4 months;
range, 6 to 79 months). The MetS was diagnosed using the modified Adult Treatment
Panel III criteria, and to eliminate covariate differences, a propensity score
adjustment was used. Major adverse cerebral and cardiovascular events were
investigated, and C-reactive protein levels were assessed both preoperatively,
postoperatively, and at follow-up. RESULTS: A total of 798 of 1,726 patients
(46.2%) met the diagnostic criteria for MetS. At follow-up, all-cause mortality (7%
versus 4.6%; p=0.04), cardiac arrhythmias (35.3% versus 25.2%; p<0.0001), renal
failure (12% versus 8.7%; p=0.03), and major adverse cerebral and cardiovascular
events (52.4% versus 39.5%; p<0.0001) showed a significantly higher incidence in
MetS patients. Variables correlated with late mortality at propensity-adjusted Cox
proportional-hazards regression were age (p=0.0008), preoperative left ventricular
ejection fraction (p=0.001), preoperative renal failure (p=0.001), and MetS
(p=0.006). Higher C-reactive protein levels were found preoperatively (8.6±2.3
versus 5.14±3.1 mg/L; p<0.0001) and both early (71.2±9 versus 49.6±8.7 mg/L;
p<0.0001) and late (7.4±2.7 versus 4.8±2.5 mg/L; p<0.0001) after surgery.
CONCLUSIONS: The main finding of our study was the association between MetS and
mortality both early and late after coronary artery bypass grafting. Thus, MetS
should be recognized as an independent preoperative variable that can lead to the
identification of high-risk patients and as a risk factor to correct with lifestyle
modifications and pharmacologic therapy.
AD - Cardiac Surgery Department, University of Rome La Sapienza, Faculty of
Medicine and Psychology, Rome, Italy. emilianoangeloni@gmail.com
AN - 22197615
AU - Angeloni, E.
AU - Melina, G.
AU - Benedetto, U.
AU - Refice, S.
AU - Capuano, F.
AU - Roscitano, A.
AU - Comito, C.
AU - Sinatra, R.
DA - Feb
DO - 10.1016/j.athoracsur.2011.10.066
DP - NLM
ET - 2011/12/27
IS - 2
J2 - The Annals of thoracic surgery
KW - Aged
Arrhythmias, Cardiac/mortality
Blood Glucose/analysis
Cause of Death
Coronary Artery Bypass/*statistics & numerical data
Diabetes Complications/blood/epidemiology
Female
Follow-Up Studies
Heart Diseases/epidemiology
Humans
Inflammation/blood
Kidney Failure, Chronic/mortality
Lipids/blood
Male
Metabolic Syndrome/blood/*epidemiology
Middle Aged
Postoperative Complications/epidemiology
Risk Factors
Stroke/epidemiology
Treatment Outcome
LA - eng
N1 - 1552-6259
Angeloni, Emiliano
Melina, Giovanni
Benedetto, Umberto
Refice, Simone
Capuano, Fabio
Roscitano, Antonino
Comito, Cosimo
Sinatra, Riccardo
Journal Article
Netherlands
Ann Thorac Surg. 2012 Feb;93(2):537-44. doi: 10.1016/j.athoracsur.2011.10.066. Epub
2011 Dec 23.
PY - 2012
SN - 0003-4975
SP - 537-44
ST - Metabolic syndrome affects midterm outcome after coronary artery bypass
grafting
T2 - Ann Thorac Surg
TI - Metabolic syndrome affects midterm outcome after coronary artery bypass
grafting
VL - 93
ID - 2617
ER -
TY - JOUR
AB - BACKGROUND: Echocardiographically determined left ventricular hypertrophy
(LVH) is a marker of cardiovascular disease related to prognosis and clinical
outcomes. We sought to determine if LVH is a measure of outcomes in atrial
fibrillation (AF) patients. METHODS: We performed a post-hoc analysis of patients
with echocardiographic data enrolled in the Atrial Fibrillation Follow-up
Investigation of Rhythm Management (AFFIRM) Trial. Patients were stratified based
on gender-adjusted echocardiography derived interventricular septal (IVS)
thickness, relative wall thickness (RWT), gender-adjusted LV mass, and type of LV
remodeling (normal LV geometry, concentric hypertrophy, eccentric hypertrophy, and
concentric remodeling). RESULTS: Of 4060 patients in AFFIRM, echocardiographic data
were available in 2433 patients (60%). Multivariate analysis revealed that LVH
defined as moderately or severely abnormal IVS thickness was an independent
predictor of both all cause mortality (HR 1.46, 95%CI 1.14-1.86, p=0.003) and
stroke (HR 1.89, 95%CI 1.17-3.08, p=0.01). This association was confirmed when IVS
thickness was assessed as continuous or categorical variable. Concentric LV
hypertrophy was associated with the highest rates of all cause mortality (HR 1.53;
95%CI 1.11-2.12; p=0.009). CONCLUSION: An easily obtained echocardiographic index
of LVH (IVS thickness) may enhance risk stratification of patients with AF, and
raise the possibility that LVH regression should be a therapeutic target in this
population.
Division of Cardiovascular Medicine, University of Iowa Hospitals and Clinics, Iowa
City, IA, United States.
Birmingham, United Kingdom. Electronic address: g.y.h.lip@bham.ac.uk.
AN - 24315343
AU - Sullivan, R. M.
AU - Olshansky, B.
AU - Lip, G. Y.
DA - Jan 1
DO - 10.1016/j.ijcard.2013.11.002
DP - NLM
ET - 2013/12/10
IS - 3
J2 - International journal of cardiology
KW - Aged
Atrial Fibrillation/*diagnostic imaging/*mortality
Brain Ischemia/mortality
Echocardiography
Female
Follow-Up Studies
Humans
Hypertrophy, Left Ventricular/*diagnostic imaging/*mortality
Male
Middle Aged
Outcome Assessment, Health Care
Prognosis
Risk Factors
Stroke/mortality
Ventricular Remodeling
All cause mortality
Atrial fibrillation
Left ventricular geometry
Left ventricular hypertrophy
Stroke
LA - eng
N1 - 1874-1754
Sullivan, Renee M
Olshansky, Brian
Lip, Gregory Y H
Journal Article
Netherlands
Int J Cardiol. 2014 Jan 1;170(3):303-8. doi: 10.1016/j.ijcard.2013.11.002. Epub
2013 Nov 13.
PY - 2014
SN - 0167-5273
SP - 303-8
ST - Left ventricular geometry and outcomes in patients with atrial fibrillation:
the AFFIRM Trial
T2 - Int J Cardiol
TI - Left ventricular geometry and outcomes in patients with atrial fibrillation:
the AFFIRM Trial
VL - 170
ID - 2515
ER -
TY - JOUR
AB - Atrial arrhythmias are commonly encountered by the primary care clinician.
They are usually asymptomatic or have only minor symptoms, unless the ventricular
rate becomes very rapid. The challenges for the clinician are to recognize the
benign from the more severe arrhythmias, to identify and treat the precipitating
cause, to control the symptoms that concern the patient, and to prevent any
complications. There are new medicinal and nonmedicinal treatments available that
offer greater likelihood of acute and long-term success in the treatment, and
sometimes cure, of the original arrhythmias.
AD - Department of Family Practice, 96th Medical Group, Family Practice Residency
Program, Eglin Air Force Base, Florida, USA.
AN - 10918675
AU - Applegate, T. E.
DA - Sep
DO - 10.1016/s0095-4543(05)70169-x
DP - NLM
ET - 2000/08/05
IS - 3
J2 - Primary care
KW - Adult
Aged
Aged, 80 and over
Anti-Arrhythmia Agents/therapeutic use
Arrhythmias, Cardiac/complications/*diagnosis/etiology/physiopathology/*therapy
Cardiac Surgical Procedures
Electrocardiography
*Heart Atria
Humans
Middle Aged
Stroke/complications/epidemiology/prevention & control
United States/epidemiology
LA - eng
N1 - Applegate, T E
Journal Article
Review
United States
Prim Care. 2000 Sep;27(3):677-708;vi. doi: 10.1016/s0095-4543(05)70169-x.
PY - 2000
SN - 0095-4543 (Print)
0095-4543
SP - 677-708;vi
ST - Atrial arrhythmias
T2 - Prim Care
TI - Atrial arrhythmias
VL - 27
ID - 2584
ER -
TY - JOUR
AB - A 7-year prospective study of 379 hypertensive patients was conducted with
primary comprehensive clinical and device examination of the patients in hospital
followed by annual control in hospital or outpatient setting. Two groups were
formed: with uncomplicated essential hypertension (EH)(n = 263, group 1); with EH
complicated by brain infarction (BI) (n = 116, group 2). Overall prognostic
correctness was 85.9%. BI was predicted by age, smoking, high intake of salt,
absence of regular antihypertensive therapy, non-dipper pattern, low output,
atherosclerotic changes of major head arteries, frequent paroxysms of cardiac
fibrillation, ventricular extrasystole, abnormal blood rheology. Integral index of
the patient condition calculated on the basis of the decisive prognosis rule (data
of the primary examination + MI within 7-year follow-up) enables targeted
prevention of cerebral complications.
AN - 15164507
AU - Ardashev, V. N.
AU - Fursov, A. N.
AU - Konev, A. V.
AU - Kulichik, T. D.
AU - Chubarova, O. G.
AU - Krivozubov, E. F.
DP - NLM
ET - 2004/05/29
IS - 4
J2 - Klinicheskaia meditsina
KW - Adult
Cerebral Infarction/*etiology/physiopathology
Female
Humans
Hypertension/*complications/diagnostic imaging/physiopathology
Male
Middle Aged
Predictive Value of Tests
Prognosis
Risk Factors
Ultrasonography, Doppler
LA - rus
N1 - Ardashev, V N
Fursov, A N
Konev, A V
Kulichik, T D
Chubarova, O G
Krivozubov, E F
Journal Article
Russia (Federation)
Klin Med (Mosk). 2004;82(4):40-3.
OP - Prognozirovanie razvitiia infarkta mozga u bol'nykh gipertonicheskoĭ
bolezn'iu.
PY - 2004
SN - 0023-2149 (Print)
0023-2149
SP - 40-3
ST - [Prediction of brain infarction in hypertensive patients]
T2 - Klin Med (Mosk)
TI - [Prediction of brain infarction in hypertensive patients]
VL - 82
ID - 2864
ER -
TY - JOUR
AB - Hypokalemia, as an adverse consequence of severe alkalosis, can prolong QT
interval and cause torsades de pointes. This report describes a rare case of
central neurogenic hyperventilation as a result of brainstem infarct, presenting
primarily with refractory ventricular tachyarrhythmia due to secondary hypokalemia.
AD - Institute of Cardiovascular Diseases, Madras Medical Mission, Chennai, Tamil
Nadu.
AN - 20635740
AU - Ardhanari, S.
AU - Gomathi, S. B.
AU - Anita, L.
AU - Harish, A.
AU - Ajit, S. M.
AU - Pandurangi, U. M.
DA - Jul-Aug
DP - NLM
ET - 2010/07/20
IS - 4
J2 - Indian heart journal
KW - Adult
Alkalosis, Respiratory/complications
Cerebral Infarction/*complications/*diagnosis/etiology
Fatal Outcome
Female
Humans
Torsades de Pointes/*etiology
LA - eng
N1 - Ardhanari, Sivakumar
Gomathi S, Balashankar
Anita, L
Harish, A
Ajit S, Mullasari
Pandurangi, Ulhas M
Case Reports
Journal Article
India
Indian Heart J. 2009 Jul-Aug;61(4):368-70.
PY - 2009
SN - 0019-4832 (Print)
0019-4832
SP - 368-70
ST - Brainstem infarct presenting as torsades de pointes
T2 - Indian Heart J
TI - Brainstem infarct presenting as torsades de pointes
VL - 61
ID - 2767
ER -
TY - JOUR
AB - Atrial fibrillation (AF) is common during the course of acute myocardial
infarction and is associated with left atrial (LA) dilatation. However, the role of
LA depolarization abnormality on the electrocardiogram (ECG) in the setting of LA
dilatation was not studied in this context. Patients admitted with non-ST-segment
elevation myocardial infarction (NSTEMI) who developed new-onset AF (International
Classification of Diseases, Ninth Revision code 427.31) were prospectively
identified. Baseline ECGs and echocardiograms before the admission event were
reviewed. Follow-up was directed toward pertinent cardiovascular events, atrial
tachyarrhythmias, and death as end points. Of 101 patients with NSTEMI who had new-
onset AF, 88 had current echocardiograms and 69 had LA dilatation (78%). Total
follow-up was 24 months (mean 21.4). Prolonged P-wave duration (> or =110 ms) and
decreased left ventricular fractional shortening were most significant in those
with LA dilatation and were independently associated with AF. In those with LA
dilatation, the prevalence of such abnormal atrial depolarization on ECGs was 56%.
AF (43% vs 15%; p = 0.03) and heart failure (63% vs 35%; p = 0.03) occurred more
often in this subset, but there was no difference in mortality. However, the
overall prevalence of late cardiovascular complications in this subset was higher
(71% vs 45%; p = 0.02) compared with that of immediate complications (20% vs 26%; p
= 0.60). In conclusion, there is higher recurrence of AF in patients with NSTEMI
who have a combination of electrocardiographic and echocardiographic LA
abnormalities compared with those without.
AD - Division of Cardiology, Department of Medicine, St. Boniface General
Hospital/University of Manitoba, Winnipeg, Manitoba, Canada. vignendra@hotmail.com
AN - 18157961
AU - Ariyarajah, V.
AU - Malinski, M.
AU - Khadem, A.
AU - Harizi, R.
AU - Wolfe, K.
AU - Spodick, D. H.
DA - Jan 1
DO - 10.1016/j.amjcard.2007.07.044
DP - NLM
ET - 2007/12/26
IS - 1
KW - Aged
Atrial Fibrillation/diagnosis/*epidemiology
Dilatation, Pathologic/diagnostic imaging
Electrocardiography
Female
Follow-Up Studies
Heart Atria/*pathology
Humans
Male
Myocardial Infarction/*epidemiology
Prospective Studies
Recurrence
Risk Assessment
Stroke/epidemiology
Stroke Volume
Ultrasonography
LA - eng
N1 - Ariyarajah, Vignendra
Malinski, Maciej
Khadem, Aliasghar
Harizi, Robert
Wolfe, Kevin
Spodick, David H
Journal Article
United States
Am J Cardiol. 2008 Jan 1;101(1):30-4. doi: 10.1016/j.amjcard.2007.07.044. Epub 2007
Nov 13.
PY - 2008
SN - 0002-9149 (Print)
0002-9149
SP - 30-4
ST - Relation of recurrence of atrial fibrillation after non-ST-elevation acute
myocardial infarction to left atrial abnormality
T2 - Am J Cardiol
TI - Relation of recurrence of atrial fibrillation after non-ST-elevation acute
myocardial infarction to left atrial abnormality
VL - 101
ID - 2693
ER -
TY - JOUR
AB - The ECG is useful in diagnosing acute myocardial infarction and unrecognized
Q-wave myocardial infarction in the elderly. Unrecognized myocardial infarction and
myocardial infarction associated with clinical symptoms have a similar incidence of
new coronary events. Ischemic ST-segment depression on the resting ECG is
associated with an increased incidence of new coronary events. The ECG is useful in
the diagnosis of LV hypertrophy but is less sensitive and less specific than
echocardiography in diagnosing LV hypertrophy. ECG LV hypertrophy is associated
with an increased incidence of cardiovascular events in the elderly. However,
echocardiographic LV hypertrophy is more sensitive in predicting new coronary
events, atherothrombotic brain infarction, and congestive heart failure than is ECG
LV hypertrophy. The ECG is also useful in diagnosing conduction defects and
arrhythmias in the elderly. In the elderly, left bundle branch block,
intraventricular conduction defect, Type II second-degree atrioventricular block,
and pacer rhythm are associated with an increased incidence of new cardiac events,
whereas right bundle branch block, left anterior fascicular block, and first-degree
atrioventricular block are not. In the elderly, atrial fibrillation is associated
with an increased incidence of thromboembolic stroke and new cardiac events.
Premature atrial complexes and paroxysmal supraventricular tachycardia are not
associated with an increased cardiac risk. Complex ventricular arrhythmias on the
resting ECG are associated with an increased incidence of cardiac events in elderly
patients with heart disease but not in elderly patients without heart disease.
(ABSTRACT TRUNCATED AT 250 WORDS)
AD - Hebrew Hospital Home, Bronx, NY 10475.
AN - 1478052
AU - Aronow, W. S.
DA - Nov
DP - NLM
ET - 1992/11/01
IS - 11
J2 - Comprehensive therapy
KW - Aged
Arrhythmias, Cardiac/*diagnosis
Heart Block/diagnosis
Humans
Hypertrophy, Left Ventricular/diagnosis
Myocardial Ischemia/*diagnosis
Rest
LA - eng
N1 - Aronow, W S
Journal Article
Review
United States
Compr Ther. 1992 Nov;18(11):11-6.
PY - 1992
SN - 0098-8243 (Print)
0098-8243
SP - 11-6
ST - Usefulness of the resting electrocardiogram in the elderly
T2 - Compr Ther
TI - Usefulness of the resting electrocardiogram in the elderly
VL - 18
ID - 2847
ER -
TY - JOUR
AB - OBJECTIVE: To review the management of the older person with atrial
fibrillation (AF). DATA SOURCES: A computer-assisted search of the English language
literature (MEDLINE) database followed by a manual search of the bibliographies of
pertinent articles. STUDY SELECTION: Studies on the management of persons with AF
were screened for review. Studies of persons older than age 60 and recent studies
were emphasized. DATA EXTRACTION: Pertinent data were extracted from the reviewed
articles. Emphasis was placed on studies involving older persons. Relevant articles
were reviewed in depth. DATA SYNTHESIS: Available data about the management of
persons with paroxysmal or chronic AF were summarized CONCLUSIONS: Management of AF
includes treatment of the underlying disease and precipitating factors. Immediate
direct-current cardioversion should be performed in persons with AF associated with
an acute myocardial infarction, chest pain caused by myocardial ischemia,
hypotension, severe heart failure, or syncope. Intravenous verapamil, diltiazem, or
beta-blockers should be used to slow a very rapid ventricular rate associated with
AF immediately. Oral verapamil, diltiazem, or a beta-blocker should be given if a
rapid ventricular rate occurs at rest or during exercise despite digoxin.
Amiodarone may be used in selected persons with symptomatic life-threatening AF
refractory to other drug therapy. Nondrug therapies should be performed in persons
with symptomatic AF in whom a rapid ventricular rate cannot be slowed by drug
therapy. Paroxysmal AF associated with the tachycardia-bradycardia syndrome should
be treated with a permanent pacemaker in combination with drugs. A permanent
pacemaker should be implanted in persons with AF who develop cerebral symptoms such
as dizziness or syncope associated with ventricular pauses greater than 3 seconds
that are not drug-induced. Elective cardioversion of AF should not be performed in
asymptomatic older persons with chronic AF. Unless transesophageal echocardiography
has shown no thrombus in the left atrial appendage before cardioversion, oral
warfarin should be given for 3 weeks before elective direct-current or drug
cardioversion of AF and continued for at least 4 weeks after maintenance of sinus
rhythm. Many cardiologists prefer the treatment strategy, especially in older
persons, of ventricular rate control plus warfarin rather than maintaining sinus
rhythm with antiarrhythmic drugs. Digoxin should be avoided in persons with sinus
rhythm who have a history of paroxysmal AF. Older persons with chronic or
paroxysmal AF who are at high risk for stroke or who have a history of hypertension
and no contraindications to warfarin should receive long-term warfarin to achieve
an International Normalized Ratio of 2.0 to 3.0. Older persons with AF who are at
low risk for stroke or who have contraindications to warfarin should receive 325 mg
of aspirin daily.
AD - Hebrew Hospital Home, Bronx, New York 10475, USA.
AN - 10366178
AU - Aronow, W. S.
DA - Jun
DO - 10.1111/j.1532-5415.1999.tb01602.x
DP - NLM
ET - 1999/06/12
IS - 6
J2 - Journal of the American Geriatrics Society
KW - Aged
Aged, 80 and over
Atrial Fibrillation/diagnosis/epidemiology/physiopathology/*therapy
Catheter Ablation
Disease Susceptibility
Heart Rate
Humans
Middle Aged
Prevalence
Risk Factors
LA - eng
N1 - Aronow, W S
Journal Article
Review
United States
J Am Geriatr Soc. 1999 Jun;47(6):740-8. doi: 10.1111/j.1532-5415.1999.tb01602.x.
PY - 1999
SN - 0002-8614 (Print)
0002-8614
SP - 740-8
ST - Management of the older person with atrial fibrillation
T2 - J Am Geriatr Soc
TI - Management of the older person with atrial fibrillation
VL - 47
ID - 2809
ER -
TY - JOUR
AB - The prevalence and incidence of atrial fibrillation increase with age. Atrial
fibrillation is associated with a higher incidence of coronary events, stroke, and
mortality than sinus rhythm. A fast ventricular rate associated with atrial
fibrillation may cause tachycardia-related cardiomyopathy. Management of atrial
fibrillation includes treatment of underlying causes and precipitating factors.
Immediate direct-current cardioversion should be performed in persons with atrial
fibrillation associated with acute myocardial infarction, chest pain due to
myocardial ischemia, hypotension, severe heart failure, or syncope. Intravenous
beta-blockers, verapamil, or diltiazem may be used to immediately slow a fast
ventricular rate associated with atrial fibrillation. An oral beta-blocker,
verapamil, or diltiazem should be given to persons with atrial fibrillation if a
rapid ventricular rate occurs a rest or during exercise despite digoxin. Amiodarone
may be used in selected persons with symptomatic life-threatening atrial
fibrillation refractory to other drug therapy. Nondrug therapies should be
performed in persons with symptomatic atrial fibrillation in whom a rapid
ventricular rate cannot be slowed by drug therapy. Paroxysmal atrial fibrillation
associated with the tachycardia-bradycardia syndrome should be managed with a
permanent pacemaker in combination with drugs. A permanent pacemaker should be
implanted in persons with atrial fibrillation in whom symptoms such as dizziness or
syncope associated with non-drug-induced ventricular pauses longer than 3 seconds
develop. Elective direct-current cardioversion has a higher success rate and a
lower incidence of cardiac adverse effects than medical cardioversion in converting
atrial fibrillation to sinus rhythm. Unless transesophageal echocardiography shows
no thrombus in the left atrial appendage before cardioversion, oral warfarin should
be given for 3 weeks before elective direct-current or drug cardioversion of atrial
fibrillation and continued for at least 4 weeks after maintenance of sinus rhythm.
Many cardiologists prefer the treatment strategy of ventricular rate control plus
warfarin rather than to maintain sinus rhythm with antiarrhythmic drugs, especially
in older patients. Digoxin should not be used in persons with paroxysmal atrial
fibrillation. Patients with chronic or paroxysmal atrial fibrillation who are at
high risk for stroke should be treated with long-term warfarin to achieve an
International Normalized Ratio (INR) of 2.0 to 3.0. Persons with atrial
fibrillation who are at low risk for stroke or who have contraindications to
warfarin should receive 325 mg aspirin daily.
AD - Department of Medicine, Westchester Medical Center/New York Medical College,
Valhalla, New York 10595, USA. WSAronow@aol.com
AN - 11975840
AU - Aronow, W. S.
DA - Mar-Apr
DO - 10.1097/00132580-200203000-00006
DP - NLM
ET - 2002/04/27
IS - 2
J2 - Heart disease (Hagerstown, Md.)
KW - Age Factors
Aged
Aged, 80 and over
*Atrial Fibrillation/complications/epidemiology/therapy
Causality
Electrocardiography
Female
Humans
Incidence
Male
Middle Aged
Prevalence
Stroke/epidemiology/etiology/therapy
Thromboembolism/epidemiology/etiology/therapy
Ventricular Dysfunction, Left/complications/epidemiology
LA - eng
N1 - Aronow, Wilbert S
Journal Article
Review
United States
Heart Dis. 2002 Mar-Apr;4(2):91-101. doi: 10.1097/00132580-200203000-00006.
PY - 2002
SN - 1521-737X (Print)
1521-737x
SP - 91-101
ST - Atrial fibrillation
T2 - Heart Dis
TI - Atrial fibrillation
VL - 4
ID - 2508
ER -
TY - JOUR
AB - Patients with obstructive sleep apnea (OSA) have an increased prevalence of
systemic and pulmonary hypertension, left ventricular (LV) hypertrophy, LV systolic
and diastolic dysfunction, and congestive heart failure, increased platelet
aggregability, and increased susceptibility to thrombotic and embolic cardiac and
cerebrovascular events. Patients with OSA have an increased prevalence of coronary
artery disease, myocardial infarction, nocturnal angina, and myocardial ischemia,
arrhythmias, and sudden cardiac death. Patients with OSA also have an increased
prevalence of stroke. Treatment of OSA with continuous positive airway pressure
improves cardiac efficiency in patients with heart failure, causes a reduction in
the frequency of nocturnal ischemic ST-segment depression, relieves nocturnal
angina, and causes a reduction in the occurrence of new cardiovascular events and
an increase in the time to such events.
AD - Department of Medicine, Division of Cardiology, New York Medical College,
Valhalla, NY 10595, USA. WSAronow@aol.com
AN - 18004019
AU - Aronow, W. S.
DA - Summer
DO - 10.1007/s12019-007-8004-9
DP - NLM
ET - 2007/11/16
IS - 2
J2 - Comprehensive therapy
KW - Arrhythmias, Cardiac/complications
Cardiovascular Diseases/*complications
Coronary Artery Disease/complications
Heart Failure/complications
Humans
Sleep Apnea, Obstructive/*complications
Stroke/complications
LA - eng
N1 - Aronow, Wilbert S
Journal Article
United States
Compr Ther. 2007 Summer;33(2):82-6. doi: 10.1007/s12019-007-8004-9.
PY - 2007
SN - 0098-8243 (Print)
0098-8243
SP - 82-6
ST - Cardiovascular manifestations seen in obstructive sleep apnea
T2 - Compr Ther
TI - Cardiovascular manifestations seen in obstructive sleep apnea
VL - 33
ID - 2456
ER -
TY - JOUR
AB - Atrial fibrillation (AF) is often complicated by a life-threatening
ventricular response, and emergency electrocardioversion and/or drug therapy to
reduce the rapid ventricular rate may be necessary. However, patients with AF and
Wolff-Parkinson-White syndrome should not be given digoxin or calcium channel
blockers. Elective direct current (DC) cardioversion has a higher success rate and
a lower incidence of cardiac adverse effects than does medical cardioversion in
converting AF to sinus rhythm. Unless transesophageal echocardiography has shown no
thrombus in the left atrial appendage before cardioversion, oral warfarin should be
given for 3 weeks before elective direct current or drug cardioversion of AF and
continued for at least 4 weeks after maintenance of sinus rhythm. Many
cardiologists prefer, especially in older patients, ventricular rate control plus
warfarin rather than maintaining sinus rhythm with antiarrhythmic drugs. Patients
with chronic or paroxysmal AF at high risk for stroke should be treated with long-
term warfarin to achieve an international normalized ratio of 2.0-3.0. Patients
with AF at low risk for stroke or with contraindications to warfarin should be
treated with aspirin 325 mg daily. Management of atrial flutter is similar to
management of AF.
AD - Department of Medicine, Division of Cardiology, New York Medical
College/Westchester Medical Center, Valhalla, New York 10595, USA. wsaronow@aol.com
AN - 18708824
AU - Aronow, W. S.
DA - Sep-Oct
DO - 10.1097/CRD.0b013e3181723694
DP - NLM
ET - 2008/08/19
IS - 5
J2 - Cardiology in review
KW - Anti-Arrhythmia Agents/therapeutic use
Atrial Fibrillation/complications/drug therapy/physiopathology/*therapy
Atrial Flutter/complications/drug therapy/physiopathology/*therapy
Humans
Platelet Aggregation Inhibitors/therapeutic use
Risk Factors
Stroke/etiology
LA - eng
N1 - 1538-4683
Aronow, Wilbert S
Journal Article
Review
United States
Cardiol Rev. 2008 Sep-Oct;16(5):230-9. doi: 10.1097/CRD.0b013e3181723694.
PY - 2008
SN - 1061-5377
SP - 230-9
ST - Treatment of atrial fibrillation and atrial flutter: Part II
T2 - Cardiol Rev
TI - Treatment of atrial fibrillation and atrial flutter: Part II
VL - 16
ID - 2505
ER -
TY - JOUR
AB - Atrial fibrillation (AF) is associated with a higher incidence of mortality,
stroke, and coronary events than is sinus rhythm. AF with a rapid ventricular rate
may cause a tachycardia-related cardiomyopathy. Immediate direct-current (DC)
cardioversion should be performed in patients with AF and acute myocardial
infarction, chest pain due to myocardial ischemia, hypotension, severe heart
failure, or syncope. Intravenous beta blockers, diltiazem, or verapamil may be
administered to slow immediately a very rapid ventricular rate in AF. An oral beta
blocker, verapamil, or diltiazem should be used in persons with AF if a fast
ventricular rate occurs at rest or during exercise despite digoxin. Amiodarone may
be used in selected patients with symptomatic life-threatening AF refractory to
other drugs. Digoxin should not be used to treat patients with paroxysmal AF.
Nondrug therapies should be performed in patients with symptomatic AF in whom a
rapid ventricular rate cannot be slowed by drugs. Paroxysmal AF associated with the
tachycardia-bradycardia syndrome should be treated with a permanent pacemaker in
combination with drugs. A permanent pacemaker should be implanted in patients with
AF and symptoms such as dizziness or syncope associated with ventricular pauses
greater than 3 seconds which are not drug-induced. Elective DC cardioversion has a
higher success rate and a lower incidence of cardiac adverse effects than does
medical cardioversion in converting AF to sinus rhythm. Unless transesophageal
echocardiography has shown no thrombus in the left atrial appendage before
cardioversion, oral warfarin should be given for 3 weeks before elective DC or drug
cardioversion of AF and continued for at least 4 weeks after maintenance of sinus
rhythm. Many cardiologists prefer, especially in older patients, ventricular rate
control plus warfarin rather than maintaining sinus rhythm with antiar-rhythmic
drugs. Patients with chronic or paroxysmal AF at high risk for stroke should be
treated with long-term warfarin to achieve an International Normalized Ratio of 2.0
to 3.0. Patients with AF at low risk for stroke or with contraindications to
warfarin should be treated with aspirin 325 mg daily.
AD - Division of Cardiology, Department of Medicine New York Medical College,
Alhalla, New York, NY, USA. wsaronow@aol.com
AN - 19182738
AU - Aronow, W. S.
DA - Feb
DP - NLM
ET - 2009/02/03
IS - 1
J2 - Minerva medica
KW - Aged
Aged, 80 and over
Atrial Fibrillation/complications/*therapy
Catheter Ablation
Humans
Middle Aged
Risk
LA - eng
N1 - Aronow, W S
Journal Article
Review
Italy
Minerva Med. 2009 Feb;100(1):3-24. Epub 2009 Jan 30.
PY - 2009
SN - 0026-4806 (Print)
0026-4806
SP - 3-24
ST - Management of atrial fibrillation in the elderly
T2 - Minerva Med
TI - Management of atrial fibrillation in the elderly
VL - 100
ID - 2595
ER -
TY - JOUR
AB - In the total population, cerebrovascular ischemic diseases account for 0.2-
0.3% cases per year, and in the 20-40% of them it is possible to recognize a
cardioembolic mechanism. The cardiological examination in patients with stroke is,
therefore, aimed at detecting cardiac sources of emboli (left atrial, valvular, and
ventricular thrombosis, atherosclerotic plaques of ascending aorta), and at
identifying the cardiovascular disease directly or indirectly associated with
ischemic stroke. Transesophageal echocardiography (TEE) is particularly suitable
for this purpose, due to the proximity of the transducer to the posterior cardiac
structures and to its better resolution. Many recent reports have demonstrated that
TEE not only improves the recognition of known cardioembolic diseases (intracardiac
thrombi, mitral stenosis, valvular prosthesis thrombosis, endocardial infectious
diseases), but is also the most reliable non invasive technique suitable to detect
atherosclerotic lesions of the ascending aorta. Furthermore, TEE allowed to
recognize new anatomic and functional abnormalities, such as left atrial
spontaneous echo contrast, atrial septal aneurysm, patent foramen ovale, frequently
associated with stroke. Noteworthy, TEE is the only technique suitable for
functional and anatomic evaluation of the left atrial appendage. The Authors
studied by TEE the functional properties of left atrial appendage in patients with
severe mitral stenosis with or without atrial fibrillation, as compared to patients
with left atrial thrombosis. Results showed that fractional shortening of left
appendage was greatly reduced, at the same extent in the 3 groups, demonstrating
that abnormalities in left atrial appendage emptying could be a risk factor for
atrial thrombosis. In order to compare TEE with the transthoracic 2D-echo for the
detection of cardioembolic sources, the Authors studied 63 patients with ischemic
stroke. TEE revealed a possible cardioembolic source in 70% of younger patients and
in 50% of patients older than 45 years. These abnormalities were detected by TEE
respectively in 10% and in 1.8% of cases. These data are in agreement with many
other reports in literature, and suggest the usefulness of TEE in the evaluation of
patients with ischemic stroke and no evidence of severe atherosclerotic
cerebrovascular disease, in contrast to the poor role of TEE. Another important
field is the prevention of stroke in patients at high risk of cardioembolic events.
The role of TEE before and immediately after cardioversion in patients with atrial
fibrillation has been recently studied by several papers. Cardioversion was proved
at low risk of stroke when TEE did not show left atrial or left appendage
thrombosis. Therefore, the transesophageal approach identifies patients needing
prolonged anticoagulation (roughly 20%), avoiding an undue, potentially dangerous
therapy.
AD - Istituto Pluridisciplinare di Clinica Medica, Università degli Studi,
Messina.
AN - 8020030
AU - Arrigo, F.
AU - Carerj, S.
AU - Pizzimenti, G.
DA - Dec
DP - NLM
ET - 1993/12/01
IS - 12 Suppl 1
J2 - Cardiologia (Rome, Italy)
KW - Adult
Aortic Diseases/complications/diagnostic imaging
Arteriosclerosis/complications/diagnostic imaging
Atrial Fibrillation/complications/diagnostic imaging
Cerebrovascular Disorders/*diagnostic imaging/epidemiology/etiology/physiopathology
Echocardiography/methods
*Echocardiography, Transesophageal
Female
Heart Aneurysm/complications/diagnostic imaging
Heart Atria/diagnostic imaging
Heart Diseases/*complications/*diagnostic imaging
Heart Neoplasms/complications/diagnostic imaging
Heart Valve Diseases/complications/diagnostic imaging
Heart Ventricles/diagnostic imaging
Humans
Male
Middle Aged
Thorax
Thrombosis/*complications/*diagnostic imaging
LA - ita
N1 - Arrigo, F
Carerj, S
Pizzimenti, G
Comparative Study
Journal Article
Review
Italy
Cardiologia. 1993 Dec;38(12 Suppl 1):301-17.
OP - Ruolo dell'ecografia transesofagea nello studio delle embolie di origine
cardiaca.
PY - 1993
SN - 0393-1978 (Print)
0393-1978
SP - 301-17
ST - [Role of transesophageal echography in the study of embolism of cardiac
origin]
T2 - Cardiologia
TI - [Role of transesophageal echography in the study of embolism of cardiac
origin]
VL - 38
ID - 3050
ER -
TY - JOUR
AB - BACKGROUND: This study aimed to evaluate age at the first onset of cardiac
complications and variation of frequency of complications between different
congenital heart defects. METHODS: The analysis included participants of the Swiss
Adult Congenital Heart Disease Registry (SACHER). For this study, cardiac
complications up to the time of inclusion in SACHER were analysed. Complications
included atrial fibrillation, atrial flutter, supraventricular tachycardia,
ventricular tachycardia, complete heart block, heart failure, stroke, endocarditis,
myocardial infarction, and pulmonary hypertension. Incidence rates (IR; incidence
rate per 1000 patient-years) for different age categories and diagnosis groups were
analysed. RESULTS: Of 2731 patients (55% male, mean age 34 ± 14 years, 92,349
patient-years), a total of 767 (28%) had experienced at least 1 cardiac
complication. The majority of complications (550; 72%) occurred in adulthood (> 18
years). Apart from perioperative stroke (IR: 1.77 in age group ≤ 4 years) and
complete heart block (IR: 2.36 in age group ≤ 4 years), IR were much lower in
childhood (IR < 1 for all complications between 5 and 17 years). Incidence of
cardiac complications increased during adult life with highest IR for atrial
fibrillation and atrial flutter in the age group ≥ 50 years (IR: 17.6 and 9.7,
respectively). There were important variations of the distribution of complications
among different diagnosis groups. CONCLUSIONS: Cardiac complications are frequent
in congenital heart disease. Apart from perioperative stroke and complete heart
block, IR are low in childhood but the incidence increases during adult life. These
data underscore the need of lifelong follow-up and may help for better allocation
of resources maintaining follow-up.
AD - Department of Cardiology, University Hospital of Basel, University of Basel,
Basel, Switzerland.
Department of Cardiology, University Hospital of Basel, University of Basel, Basel,
Switzerland; Department of Cardiology, Kantonsspital St Gallen, St Gallen,
Switzerland.
University Heart Center, Department of Cardiology, University of Zurich, Zurich,
Switzerland.
Center for Congenital Heart Disease, Department of Cardiology, Inselspital,
University of Bern, Bern, Switzerland.
Department of Cardiology and Cardiac Surgery (CHUV), Centre Hospitalier
Universitaire Vaudois, Lausanne, Switzerland.
Department of Cardiology, Kantonsspital St Gallen, St Gallen, Switzerland.
The Cardiovascular Center, Klinik im Park, Zurich, Switzerland.
Department of Cardiology, University Hospital of Basel, University of Basel, Basel,
Switzerland. Electronic address: daniel.tobler@usb.ch.
AN - 30527151
AU - Arslani, K.
AU - Roffler, N.
AU - Zurek, M.
AU - Greutmann, M.
AU - Schwerzmann, M.
AU - Bouchardy, J.
AU - Rutz, T.
AU - Ehl, N. F.
AU - Jost, C. A.
AU - Tobler, D.
DA - Dec
DO - 10.1016/j.cjca.2018.09.010
DP - NLM
ET - 2018/12/12
IS - 12
J2 - The Canadian journal of cardiology
KW - Adult
Age of Onset
Aging
Arrhythmias, Cardiac/epidemiology
Endocarditis/epidemiology
Female
Heart Block/epidemiology
Heart Defects, Congenital/*epidemiology
Humans
Hypertension, Pulmonary/epidemiology
Incidence
Male
Registries
Stroke/epidemiology
Switzerland/epidemiology
LA - eng
N1 - 1916-7075
Arslani, Ketina
Roffler, Nico
Zurek, Marzena
Greutmann, Matthias
Schwerzmann, Markus
Bouchardy, Judith
Rutz, Tobias
Ehl, Niklas F
Jost, Christine Attenhofer
Tobler, Daniel
SACHER Investigators
Journal Article
England
Can J Cardiol. 2018 Dec;34(12):1624-1630. doi: 10.1016/j.cjca.2018.09.010. Epub
2018 Sep 29.
PY - 2018
SN - 0828-282x
SP - 1624-1630
ST - Patterns of Incidence Rates of Cardiac Complications in Patients With
Congenital Heart Disease
T2 - Can J Cardiol
TI - Patterns of Incidence Rates of Cardiac Complications in Patients With
Congenital Heart Disease
VL - 34
ID - 2324
ER -
TY - JOUR
AB - The last few decades have witnessed a global rise in adult obesity of
epidemic proportions. The potential impact of this is emphasized when one considers
that body mass index (BMI) is a powerful predictor of death, type 2 diabetes (T2DM)
and cardiovascular (CV) morbidity and mortality [1, 2]. Similarly we have witnessed
a parallel rise in the incidence of atrial fibrillation (AF), the commonest
sustained cardiac arrhythmia, which is also a significant cause of cardiovascular
morbidity and mortality. Part of this increase is attributable to advances in the
treatment of coronary heart disease (CHD) and heart failure (HF) improving life
expectancy and consequently the prevalence of AF. However, epidemiological studies
have demonstrated an independent association between obesity and AF, possibly
reflecting common pathophysiology and risk factors for both conditions. Indeed,
weight gain and obesity are associated with structural and functional changes of
the cardiovascular system including left atrial and ventricular remodeling,
haemodynamic alterations, autonomic dysfunction, and diastolic dysfunction.
Moreover, diabetic cardiomyopathy is characterized by an adverse structural and
functional cardiac phenotype which may predispose to the development of AF [3]. In
this review, we discuss the pathophysiological and mechanistic relationships
between obesity, diabetes and AF, and the challenges posed in the management of
this high-risk group of individuals.
AD - Division of Cardiovascular Sciences, The University of Manchester, UK.
AN - 22920475
AU - Asghar, O.
AU - Alam, U.
AU - Hayat, S. A.
AU - Aghamohammadzadeh, R.
AU - Heagerty, A. M.
AU - Malik, R. A.
C2 - PMC3492809
DA - Nov
DO - 10.2174/157340312803760749
DP - NLM
ET - 2012/08/28
IS - 4
J2 - Current cardiology reviews
KW - Adipokines/physiology
Atrial Fibrillation/*etiology/therapy
Autonomic Nervous System Diseases/etiology
Catheter Ablation/methods
Diabetes Mellitus, Type 2/*etiology
Diabetic Angiopathies/*etiology
Hemorrhage/etiology
Humans
Metabolic Syndrome/etiology
Obesity/*complications
Risk Factors
Stroke/etiology
Thrombosis/etiology
LA - eng
N1 - 1875-6557
Asghar, O
Alam, U
Hayat, S A
Aghamohammadzadeh, R
Heagerty, A M
Malik, R A
Journal Article
Review
Curr Cardiol Rev. 2012 Nov;8(4):253-64. doi: 10.2174/157340312803760749.
PY - 2012
SN - 1573-403X (Print)
1573-403x
SP - 253-64
ST - Obesity, diabetes and atrial fibrillation; epidemiology, mechanisms and
interventions
T2 - Curr Cardiol Rev
TI - Obesity, diabetes and atrial fibrillation; epidemiology, mechanisms and
interventions
VL - 8
ID - 2414
ER -
TY - JOUR
AB - Nonrheumatic atrial fibrillation (NRAF) and left ventricular hypertrophy
(LVH) have long been recognised as risk factors for cerebral ischaemia and as
predictors of recurrent vascular events. In the present study we aimed at
determining the value of NRAF and LVH as predictors of recurrent vascular events in
a cohort of patients with a first-ever episode of reversible ischemic neurological
deficit (RIND). The study included 54 patients (37 men and 17 women, aged 62 +/-
9.6 yrs) who had suffered RIND; they were followed up for 30 days after the stroke
in clinical conditions and for 12 months as outpatients. The patients were studied
during the hospital stay by means of routine tests (electrocardiography, standard
laboratory tests) and specialised studies (computer tomography, echocardiography).
By the end of the one-year outpatient follow up there were 8 (14.8%) recurrent
cerebrovascular events. By combining the statistically significant cerebrovascular
risk factors (male sex, sudden onset of the event and moderately high systolic and
diastolic blood pressure) with factors not reaching statistical significance (LVH,
NRAF) we developed a statistically significant prediction model for patients with
RIND.
AD - Clinic of Neurology, Medical University, Plovdiv, Bulgaria.
AN - 12751684
AU - Atanassova, P. A.
AU - Vukov, M. I.
AU - Chalakova, N. T.
AU - Tokmakova, M. P.
AU - Dobreva, B. V.
DP - NLM
ET - 2003/05/20
IS - 4
J2 - Folia medica
KW - Atrial Fibrillation/*etiology
Autonomic Nervous System Diseases/*diagnosis/physiopathology
Disease Progression
Female
*Heart Conduction System/physiology
Humans
Hypertrophy, Left Ventricular/*etiology
Male
Middle Aged
Myocardial Ischemia/etiology/*physiopathology
Prognosis
LA - eng
N1 - Atanassova, Penka A
Vukov, Mircho I
Chalakova, Nedka T
Tokmakova, Maria P
Dobreva, Bistra V
Journal Article
Bulgaria
Folia Med (Plovdiv). 2002;44(4):23-7.
PY - 2002
SN - 0204-8043 (Print)
0204-8043
SP - 23-7
ST - Nonrheumatic atrial fibrillation and left ventricular hypertrophy in the
prognosis of reversible ischaemic neurological deficit
T2 - Folia Med (Plovdiv)
TI - Nonrheumatic atrial fibrillation and left ventricular hypertrophy in the
prognosis of reversible ischaemic neurological deficit
VL - 44
ID - 2982
ER -
TY - JOUR
AB - BACKGROUND: The fundamental goal of cardiopulmonary resuscitation (CPR) is
recovery of the heart and the brain. This is best achieved by (1) immediate CPR for
coronary and cerebral perfusion, (2) correction of the cause of cardiac arrest, and
(3) controlled cardioplegic cardiac reperfusion. Failure of such an integrated
therapy may cause permanent brain damage despite cardiac resuscitation. METHODS:
This strategy was applied at four centers to 34 sudden cardiac death patients (a)
after acute myocardial infarction (n = 20), (b) "intraoperatively" following
successful discontinuation of cardiopulmonary bypass (n = 4), and (c)
"postoperatively" in the surgical ICU (n = 10). In each witnessed arrest the
patient failed to respond to conventional CPR with ACLS interventions, including
defibrillation. The cardiac arrest interval was 72 +/- 43 min (20-150 min).
Compression and drugs maintained a BP > 60 mmHg to avoid cerebral hypoperfusion.
Operating room (OR) transfer was delayed until the blood pressure was monitored. In
four patients femoral bypass maintained perfusion while an angiographic diagnosis
was made. RESULTS: Management principles included no repeat defibrillation attempts
after 10 min of unsuccessful CPR, catheter-monitored peak BP > 60 mmHg during
diagnosis and transit to the operating room, left ventricular venting during
cardiopulmonary bypass and 20 min global and graft substrate enriched blood
cardioplegic reperfusion. Survival was 79.4% with two neurological complications
(5.8%). CONCLUSIONS: Recovery without adverse neurological outcomes is possible in
a large number of cardiac arrest victims following prolonged manual CPR. Therapy is
directed toward maintaining a monitored peak BP above 60 mmHg, determining the
nature of the cardiac cause, and correcting it with controlled reperfusion to
preserve function.
AD - Department of Surgery, Norwood Clinic and Kemp-Carraway Heart Institute,
Birmingham, AL, USA. dra@norwoodclinic.com
AN - 16759784
AU - Athanasuleas, C. L.
AU - Buckberg, G. D.
AU - Allen, B. S.
AU - Beyersdorf, F.
AU - Kirsh, M. M.
DA - Jul
DO - 10.1016/j.resuscitation.2005.11.017
DP - NLM
ET - 2006/06/09
IS - 1
J2 - Resuscitation
KW - Cardioplegic Solutions/therapeutic use
*Cardiopulmonary Bypass
Cardiopulmonary Resuscitation/methods
Coronary Artery Bypass
Death, Sudden, Cardiac/prevention & control
Heart Arrest/complications/mortality/*therapy
Humans
Middle Aged
Myocardial Reperfusion/methods
Resuscitation/*methods
Ventricular Fibrillation/therapy
LA - eng
N1 - Athanasuleas, Constantine L
Buckberg, Gerald D
Allen, Bradley S
Beyersdorf, Friedhelm
Kirsh, Marvin M
Journal Article
Ireland
Resuscitation. 2006 Jul;70(1):44-51. doi: 10.1016/j.resuscitation.2005.11.017. Epub
2006 Jun 6.
PY - 2006
SN - 0300-9572 (Print)
0300-9572
SP - 44-51
ST - Sudden cardiac death: directing the scope of resuscitation towards the heart
and brain
T2 - Resuscitation
TI - Sudden cardiac death: directing the scope of resuscitation towards the heart
and brain
VL - 70
ID - 2997
ER -
TY - JOUR
AB - Candidates for chronic warfarin therapy often have co-morbid conditions, such
as heart failure, with reduced left ventricular ejection fraction. Previous reports
have demonstrated an increased risk of over-anticoagulation due to reduced warfarin
dose requirement in patients with decompensated heart failure. However, the
influence of left ventricular systolic dysfunction (LVSD), defined as left
ventricular ejection fraction <40%, on warfarin response has not been evaluated.
Here, we assess the influence of LVSD on warfarin dose, anticoagulation control
(percent time in target range), and risk of over-anticoagulation (international
normalized ratio >4) and major hemorrhage. Of the 1,354 patients included in this
prospective cohort study, 214 patients (16%) had LVSD. Patients with LVSD required
11% lower warfarin dose compared with those without LVSD (p <0.001) using
multivariate linear regression analyses. Using multivariate Cox proportional
hazards model, patients with LVSD experienced similar levels of anticoagulation
control (percent time in target range: 51% vs 53% p = 0.15), risk of over-
anticoagulation (international normalized ratio >4; hazard ratio 1.01, 95%
confidence interval 0.82 to 1.25; p = 0.91), and risk of major hemorrhage (hazard
ratio 1.11; 95% confidence interval 0.70 to 1.74; p = 0.66). Addition of LVSD
variable in the model increased the variability explained from 35% to 36% for
warfarin dose prediction. In conclusion, our results demonstrate that patients with
LVSD require lower doses of warfarin. Whether warfarin dosing algorithms
incorporating LVSD in determining initial doses improves outcomes needs to be
evaluated.
AD - Division of Cardiovascular Disease, Department of Medicine, University of
Alabama at Birmingham, Alabama.
Department of Epidemiology, University of Alabama at Birmingham, Alabama.
Section on Statistical Genetics, Department of Biostatistics, University of Alabama
at Birmingham, Alabama.
Department of Pathology and Laboratory Medicine, Emory University, Atlanta,
Georgia.
Department of Neurology, University of Alabama at Birmingham, Alabama. Electronic
address: nlimdi@uab.edu.
AN - 27241839
AU - Ather, S.
AU - Shendre, A.
AU - Beasley, T. M.
AU - Brown, T.
AU - Hill, C. E.
AU - Prabhu, S. D.
AU - Limdi, N. A.
C2 - PMC4962063
C6 - NIHMS791202
DA - Jul 15
DO - 10.1016/j.amjcard.2016.04.047
DP - NLM
ET - 2016/06/01
IS - 2
KW - Aged
Algorithms
Atrial Fibrillation/complications/drug therapy/epidemiology
Cohort Studies
Comorbidity
Dose-Response Relationship, Drug
Drug Dosage Calculations
Female
Heart Failure/epidemiology/*physiopathology
Hemorrhage/*chemically induced
Humans
Ischemic Attack, Transient/drug therapy/epidemiology/etiology/prevention & control
Linear Models
Male
Middle Aged
Myocardial Infarction/drug therapy/epidemiology
Peripheral Arterial Disease/drug therapy/epidemiology
Prospective Studies
Risk Factors
Stroke/drug therapy/epidemiology/etiology/prevention & control
Stroke Volume
Venous Thromboembolism/drug therapy/epidemiology
Ventricular Dysfunction, Left/epidemiology/*physiopathology
Ventricular Function, Left
LA - eng
N1 - 1879-1913
Ather, Sameer
Shendre, Aditi
Beasley, T Mark
Brown, Todd
Hill, Charles E
Prabhu, Sumanth D
Limdi, Nita A
K24 HL133373/HL/NHLBI NIH HHS/United States
UL1 RR025777/RR/NCRR NIH HHS/United States
R01 HL092173/HL/NHLBI NIH HHS/United States
R01 GM081488/GM/NIGMS NIH HHS/United States
Journal Article
Am J Cardiol. 2016 Jul 15;118(2):232-6. doi: 10.1016/j.amjcard.2016.04.047. Epub
2016 May 5.
PY - 2016
SN - 0002-9149 (Print)
0002-9149
SP - 232-6
ST - Effect of Left Ventricular Systolic Dysfunction on Response to Warfarin
T2 - Am J Cardiol
TI - Effect of Left Ventricular Systolic Dysfunction on Response to Warfarin
VL - 118
ID - 2594
ER -
TY - JOUR
AB - PURPOSE: In an effort to reduce the frequency of central nervous system (CNS)
progression in patients with metastatic melanoma with ongoing systemic response to
biochemotherapy, we modified our standard concurrent biochemotherapy regimen by
replacing dacarbazine (DTIC) with oral temozolomide. EXPERIMENTAL DESIGN: Patients
received cisplatin, vinblastine, and temozolomide (20 mg/m(2) cisplatin and 1.2
mg/m(2) vinblastine i.v., days 1-4; 150 mg/m(2) p.o. temozolomide, days 1-4)
concurrent with interleukin 2 (9 MIU/m(2)/day) by continuous i.v. infusion on days
1-4 and IFN-alpha (5 MU/m(2)/day) on days 1-5, 8, 10, and 12. Prophylactic
antibiotics and a maximum of four cycles were administered. Routine granulocyte-
colony stimulating factor and aggressive antiemetics were also provided. Tumor
staging included torso computed tomography scans and brain magnetic resonance
imaging pretreatment, after cycle 4 and then every 3 months for 2 years. Torso
computed tomography scans were also performed after cycle 2. RESULTS: A total of
147 treatment cycles were administered to 48 patients. No patients had received
prior chemotherapy or interleukin 2; however, 19 (40%) had received prior adjuvant
IFN-alpha. Significant toxicities included 2 deaths from cardiac events
(pericarditis al tamponade and posttreatment myocardial infarction with associated
ventricular arrhythmia) and 3 gastrointestinal serious adverse events
(pancreatitis, appendicitis, and upper GI bleed). No other nonhematological grade 4
toxicities were observed. Tumor responses were seen in 22 of 47 evaluable patients
(relative risk, 47%) with 7 complete responses (15%). Response durations ranged
from 1 to 29+ months with 1 currently ongoing. Median survival was 7.5 months. The
CNS was the initial site of progression in 2 responding patients. An additional 6
responding patients developed CNS progression within 3 months of systemic
progression. Initial CNS progression was significantly less frequent what was seen
with the prior DTIC-based biochemotherapy regimen (2 of 22 versus 12 of 19; P =
0.001). CONCLUSION: This regimen appears to be active and reasonably well tolerated
in patients with metastatic melanoma. Although the substitution of temozolomide for
DTIC reduced the incidence of initial CNS progression, this effect did not appear
to result in an improved overall outcome.
AD - Department of Medicine, Division of Hematology/Oncology, Beth Israel
Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
matkins@caregroup.harvard.edu
AN - 12374674
AU - Atkins, M. B.
AU - Gollob, J. A.
AU - Sosman, J. A.
AU - McDermott, D. F.
AU - Tutin, L.
AU - Sorokin, P.
AU - Parker, R. A.
AU - Mier, J. W.
DA - Oct
DP - NLM
ET - 2002/10/11
IS - 10
J2 - Clinical cancer research : an official journal of the American Association
for Cancer Research
KW - Adult
Aged
Antineoplastic Combined Chemotherapy Protocols/adverse effects/*therapeutic use
Brain Neoplasms/*drug therapy/pathology
Cisplatin/administration & dosage/adverse effects
Dacarbazine/administration & dosage/adverse effects/*analogs & derivatives
Female
Granulocyte Colony-Stimulating Factor/therapeutic use
Humans
Infusions, Intravenous
Interferon alpha-2
Interferon-alpha/administration & dosage/adverse effects
Interleukin-2/administration & dosage/adverse effects
Male
Melanoma/*drug therapy/secondary
Middle Aged
Pilot Projects
Recombinant Proteins
Temozolomide
Treatment Outcome
Vinblastine/administration & dosage/adverse effects
LA - eng
N1 - Atkins, Michael B
Gollob, Jared A
Sosman, Jeffrey A
McDermott, David F
Tutin, Linda
Sorokin, Patricia
Parker, Robert A
Mier, James W
Clinical Trial
Clinical Trial, Phase II
Comparative Study
Journal Article
United States
Clin Cancer Res. 2002 Oct;8(10):3075-81.
PY - 2002
SN - 1078-0432 (Print)
1078-0432
SP - 3075-81
ST - A phase II pilot trial of concurrent biochemotherapy with cisplatin,
vinblastine, temozolomide, interleukin 2, and IFN-alpha 2B in patients with
metastatic melanoma
T2 - Clin Cancer Res
TI - A phase II pilot trial of concurrent biochemotherapy with cisplatin,
vinblastine, temozolomide, interleukin 2, and IFN-alpha 2B in patients with
metastatic melanoma
VL - 8
ID - 3120
ER -
TY - JOUR
AB - A 65-year-old man with previous history of congestive heart failure and
genetically proven Becker muscular dystrophy (BMD) was suddenly suffered from
aphasia and right hemiplegia. Physical examination showed severe motor aphasia,
right hemiplegia, and signs of left heart failure. An echocardiogram before the
onset of aphasia showed markedly dilated left ventricle and decreased ventricular
contraction. Intracardiac thrombus was not detected. Although his electrocardiogram
on admission showed sinus rhythm, atrial fibrillation was noted at the time of
neurological deterioration. MRI of the brain revealed acute infarction in the
territory of the left middle cerebral artery and the left anterior inferior
cerebellar artery. MR angiography showed vascular occlusion at the left M2 segment.
Cerebral embolism due to atrial fibrillation associated with BMD-related DCM was
diagnosed. While an administration of anti-coagulant, diuretics, and dopamine
relieved his respiratory distress and right hemiplegia, severe motor aphasia
persisted. Cerebral embolism may be a notable complication in patients with BMD
presenting with late-life expression of skeletal muscular weakness and antecedent
cardiac involvement.
AD - Department of Neurology, Baba Memorial Hospital, 4-244 Higashi,
Hamaderafunao-cho, Sakai, Osaka 592-8555, Japan.
AN - 15098362
AU - Atsumi, M.
AU - Tanaka, A.
AU - Kawarabayashi, T.
AU - Nishio, S.
AU - Sakamoto, H.
AU - Hasegawa, T.
AU - Kitaguchi, M.
DA - Feb
DP - NLM
ET - 2004/04/22
IS - 2
J2 - No to shinkei = Brain and nerve
KW - Aged
Atrial Fibrillation/complications/diagnosis
Cardiomyopathy, Dilated/diagnosis/*etiology
Electrocardiography
Humans
Intracranial Embolism/diagnosis/*etiology
Magnetic Resonance Angiography
Male
Muscular Dystrophy, Duchenne/*complications
LA - jpn
N1 - Atsumi, Masahiko
Tanaka, Atsushi
Kawarabayashi, Takahiko
Nishio, Shunji
Sakamoto, Hikaru
Hasegawa, Takanori
Kitaguchi, Masataka
Case Reports
English Abstract
Journal Article
Japan
No To Shinkei. 2004 Feb;56(2):163-7.
PY - 2004
SN - 0006-8969 (Print)
0006-8969
SP - 163-7
ST - [Cerebral embolism associated with Becker muscular dystrophy-related dilated
cardiomyopathy]
T2 - No To Shinkei
TI - [Cerebral embolism associated with Becker muscular dystrophy-related dilated
cardiomyopathy]
VL - 56
ID - 2729
ER -
TY - JOUR
AB - BACKGROUND: Patient selection for transcatheter aortic valve implantation
(TAVI) remains a major concern. Indeed, despite promising results, it is still
unclear which patients are most and least likely to benefit from this procedure.
AIMS: To identify predictors of 6-month poor clinical outcomes after TAVI. METHODS:
Patients who were discharged from our institution with a transcatheter-implanted
aortic valve were followed prospectively. Our population was divided into two
groups ('good outcomes' and 'poor outcomes') according to occurrence of primary
endpoint (composite of all-cause mortality, all stroke, hospitalizations for valve-
related symptoms or worsening heart failure from discharge to 6 months or 6-month
New York Heart Association functional class III or IV). Patient characteristics
were studied to find predictors of poor outcomes. RESULTS: We included 163 patients
(mean age, 79.9 ± 8.8 years; 90 men [55%]; mean logistic EuroSCORE, 18.4 ± 11.4%).
The primary endpoint occurred in 49 patients (mean age, 83 ± 5 years; 31 men
[63%]). By multivariable analysis, atrial fibrillation (odds ratio [OR] 3.94),
systolic pulmonary artery pressure ≥60 mmHg (OR 7.56) and right ventricular
dysfunction (OR 3.55) were independent predictors of poor outcomes, whereas
baseline aortic regurgitation ≥2/4 (OR 0.07) demonstrated a protective effect.
CONCLUSION: Atrial fibrillation, severe baseline pulmonary hypertension and right
ventricular dysfunction (i.e. variables suggesting a more evolved aortic stenosis)
were predictors of 6-month poor outcomes. Conversely, baseline aortic regurgitation
≥2/4 showed a protective effect, which needs to be confirmed in future studies. Our
study highlights the need for a specific 'TAVI risk score', which could lead to
better patient selection.
AD - Inserm, U1099, Rennes, France; Université de Rennes 1, LTSI, Rennes, France;
CHU de Rennes, Service de Cardiologie et Maladies Vasculaires, Rennes, France;
Inserm, CIC-IT804, Rennes, France. Electronic address: vincent.auffret@chu-
rennes.fr.
Inserm, U1099, Rennes, France; Université de Rennes 1, LTSI, Rennes, France; CHU de
Rennes, Service de Cardiologie et Maladies Vasculaires, Rennes, France; Inserm,
CIC-IT804, Rennes, France.
CHU de Rennes, Service de Pharmacologie Clinique, Rennes, France.
CHU de Rennes, Service de Gériatrie, Rennes, France.
CHU de Rennes, Service de Chirurgie Cardiaque, Thoracique et Vasculaire, Rennes,
France.
AN - 24361056
AU - Auffret, V.
AU - Boulmier, D.
AU - Oger, E.
AU - Bedossa, M.
AU - Donal, E.
AU - Laurent, M.
AU - Sost, G.
AU - Beneux, X.
AU - Harmouche, M.
AU - Verhoye, J. P.
AU - Le Breton, H.
DA - Jan
DO - 10.1016/j.acvd.2013.10.005
DP - NLM
ET - 2013/12/24
IS - 1
J2 - Archives of cardiovascular diseases
KW - Aged
Aged, 80 and over
Aortic Valve Insufficiency/mortality/physiopathology
Aortic Valve Stenosis/diagnosis/mortality/physiopathology/*therapy
Atrial Fibrillation/mortality/physiopathology
Cardiac Catheterization/*adverse effects/mortality
Chi-Square Distribution
Female
Heart Failure/mortality/physiopathology
Heart Valve Prosthesis Implantation/*adverse effects/methods/mortality
Humans
Hypertension, Pulmonary/mortality/physiopathology
Logistic Models
Male
Odds Ratio
Patient Readmission
Patient Selection
Prospective Studies
Risk Factors
Stroke/mortality/physiopathology
Time Factors
Treatment Outcome
Ventricular Dysfunction, Right/mortality/physiopathology
Aortic regurgitation
Aortic stenosis
Insuffisance aortique
Outcomes
Résultat
Sténose aortique
Transcatheter aortic valve implantation
Valve aortique percutanée
LA - eng
N1 - 1875-2128
Auffret, Vincent
Boulmier, Dominique
Oger, Emmanuel
Bedossa, Marc
Donal, Erwan
Laurent, Marcel
Sost, Gwenaelle
Beneux, Xavier
Harmouche, Majid
Verhoye, Jean-Philippe
Le Breton, Hervé
Journal Article
Netherlands
Arch Cardiovasc Dis. 2014 Jan;107(1):10-20. doi: 10.1016/j.acvd.2013.10.005. Epub
2013 Dec 18.
PY - 2014
SN - 1875-2128
SP - 10-20
ST - Predictors of 6-month poor clinical outcomes after transcatheter aortic valve
implantation
T2 - Arch Cardiovasc Dis
TI - Predictors of 6-month poor clinical outcomes after transcatheter aortic valve
implantation
VL - 107
ID - 2565
ER -
TY - JOUR
AB - BACKGROUND: We evaluated cerebrovascular events (CVE) after kidney
transplantation (KTx) and sought to identify pre-transplant predictors of transient
ischaemic attacks (TIA) and strokes post-transplantation. METHODS: A total of 1617
consecutive kidney and 16 kidney-pancreas recipients transplanted between 1995 and
2005 were analysed in this retrospective single-centre study. Risk factors for CVE,
e.g. recipient and donor age and gender, diagnosis of chronic kidney disease, end-
stage renal disease (ESRD) duration, histories of hypertension, hyperlipidaemia,
smoking, atrial fibrillation (AF), diabetes mellitus (DM), ischaemic heart,
peripheral- and cerebro-vascular disease, as well as pre-transplant myocardial
infarction or CVE (i.e. TIA/strokes) were analysed. Furthermore, the predictive
value of pre-transplant screening tests, i.e. echocardiography (n = 1184) and
carotid ultrasound (n = 922), was investigated. RESULTS: During a median follow-up
of 4 years, 64 CVE (54 strokes and 10 TIA) were observed. Nineteen (5.1%) of 373
deceased patients died from fatal stroke. Recipient age, history of AF and
hyperlipidaemia (P = 0.00, respectively), reduced left ventricular function (LVF)
(P = 0.01) and the degree of stenosis by carotid ultrasound (P = 0.002), duration
of ESRD (P = 0.03) and interstitial nephritis as renal disease cause (P = 0.04)
evolved as predictors of TIA/stroke post-transplant in univariate analysis. In
multivariable analysis, AF (P = 0.001) and DM (P = 0.037) were significant
predictors for post-transplant CVE. CONCLUSIONS: AF and DM are independent
predictors of CVE after KTx. Beyond their general ability to detect severely
comorbid patients, pre-transplant screening tests (e.g. carotid ultrasound or
echocardiography) were not able to identify renal transplant candidates at risk for
CVE after transplantation.
AD - Universitätsklinik für Innere Medizin III, Medizinische Universität Wien,
Währinger Gürtel 18-20, A-1090 Wien, Austria.
AN - 18045824
AU - Aull-Watschinger, S.
AU - Konstantin, H.
AU - Demetriou, D.
AU - Schillinger, M.
AU - Habicht, A.
AU - Hörl, W. H.
AU - Watschinger, B.
DA - Apr
DO - 10.1093/ndt/gfm766
DP - NLM
ET - 2007/11/30
IS - 4
J2 - Nephrology, dialysis, transplantation : official publication of the European
Dialysis and Transplant Association - European Renal Association
KW - Atrial Fibrillation/complications/diagnosis/epidemiology
Austria/epidemiology
Echocardiography
Female
Follow-Up Studies
Humans
Incidence
Kidney Failure, Chronic/*surgery
Kidney Transplantation/*adverse effects
Male
Middle Aged
Postoperative Complications
Prognosis
Risk Factors
Stroke/diagnosis/epidemiology/*etiology
LA - eng
N1 - 1460-2385
Aull-Watschinger, Susanne
Konstantin, Hermina
Demetriou, Demetrakis
Schillinger, Martin
Habicht, Antje
Hörl, Walter H
Watschinger, Bruno
Comparative Study
Journal Article
England
Nephrol Dial Transplant. 2008 Apr;23(4):1429-35. doi: 10.1093/ndt/gfm766. Epub 2007
Nov 28.
PY - 2008
SN - 0931-0509
SP - 1429-35
ST - Pre-transplant predictors of cerebrovascular events after kidney
transplantation
T2 - Nephrol Dial Transplant
TI - Pre-transplant predictors of cerebrovascular events after kidney
transplantation
VL - 23
ID - 2656
ER -
TY - JOUR
AB - The predictive ability of the CHADS2 index to stratify stroke risk may be
mechanistically linked to severity of left atrial (LA) dysfunction. This study
investigated the association between the CHADS2 score and LA function. We performed
resting transthoracic echocardiography in 970 patients with stable coronary heart
disease and normal ejection fraction and calculated baseline LA functional index
(LAFI) using a validated formula: (LA emptying fraction×left ventricular outflow
tract velocity time integral)/LA end-systolic volume indexed to body surface area.
We performed regression analyses to evaluate the association between risk scores
and LAFI. Among 970 subjects, mean CHADS2 was 1.7±1.2. Mean LAFI decreased across
tertiles of CHADS2 (42.8±18.1, 37.8±19.1, 36.7±19.4, p<0.001). After adjustment for
age, sex, race, systolic blood pressure, hyperlipidemia, myocardial infarction,
revascularization, body mass index, smoking, and alcohol use, high CHADS2 remained
associated with the lowest quartile of LAFI (odds ratio 2.34, p=0.001). In
multivariable analysis of component co-morbidities, heart failure, age, and
creatinine clearance<60 ml/min were strongly associated with LA dysfunction. For
every point increase in CHADS2, the LAFI decreased by 4.0%. Secondary analyses
using CHA2DS2-VASc and R2CHADS2 scores replicated these results. Findings were
consistent when excluding patients with baseline atrial fibrillation. In
conclusion, CHADS2, CHA2DS2-VASc, and R2CHADS2 scores are associated with LA
dysfunction, even in patients without baseline atrial fibrillation. These findings
merit further study to determine the role of LA dysfunction in cardioembolic stroke
and the value of LAFI for risk stratification.
AD - Division of Cardiovascular Medicine, Department of Medicine, Stanford
University, Stanford, California; Veterans Affairs Medical Center, Palo Alto,
California.
Department of Medicine, University of California, San Francisco, California;
Veterans Affairs Medical Center, San Francisco, California.
Doris Duke Clinical Research Fellowship Program, University of California, San
Francisco, California; School of Medicine, University of California, Irvine,
California.
Department of Medicine, University of California, San Francisco, California;
Veterans Affairs Medical Center, San Francisco, California; Department of
Epidemiology and Biostatistics, University of California, San Francisco,
California.
Veterans Affairs Medical Center, San Francisco, California; Division of Cardiology,
Department of Medicine, University of California, San Francisco, California.
Division of Cardiovascular Medicine, Department of Medicine, Stanford University,
Stanford, California; Veterans Affairs Medical Center, Palo Alto, California.
Electronic address: mintu@stanford.edu.
AN - 24507169
AU - Azarbal, F.
AU - Welles, C. C.
AU - Wong, J. M.
AU - Whooley, M. A.
AU - Schiller, N. B.
AU - Turakhia, M. P.
DA - Apr 1
DO - 10.1016/j.amjcard.2013.12.028
DP - NLM
ET - 2014/02/11
IS - 7
KW - Aged
Atrial Fibrillation/*diagnosis/physiopathology
Atrial Function, Left/*physiology
Coronary Disease/complications/*diagnosis/physiopathology
Electrocardiography
Female
Follow-Up Studies
Humans
Incidence
Male
Middle Aged
Odds Ratio
Prognosis
Prospective Studies
Risk Assessment/*methods
Risk Factors
LA - eng
N1 - 1879-1913
Azarbal, Farnaz
Welles, Christine C
Wong, Jonathan M
Whooley, Mary A
Schiller, Nelson B
Turakhia, Mintu P
Comparative Study
Journal Article
Multicenter Study
Research Support, U.S. Gov't, Non-P.H.S.
United States
Am J Cardiol. 2014 Apr 1;113(7):1166-72. doi: 10.1016/j.amjcard.2013.12.028. Epub
2014 Jan 15.
PY - 2014
SN - 0002-9149
SP - 1166-72
ST - Association of CHADS2, CHA2DS2-VASc, and R2CHADS2 scores with left atrial
dysfunction in patients with coronary heart disease (from the Heart and Soul study)
T2 - Am J Cardiol
TI - Association of CHADS2, CHA2DS2-VASc, and R2CHADS2 scores with left atrial
dysfunction in patients with coronary heart disease (from the Heart and Soul study)
VL - 113
ID - 2488
ER -
TY - JOUR
AB - BACKGROUND: Left atrial (LA) strain as a marker for discrimination of risk
for stroke and transient ischemic attack (TIA) in patients with atrial fibrillation
and low-risk CHADS(2) scores (≤1) has yet to be examined. METHODS: Patients with
atrial fibrillation, stroke or TIA, and CHADS(2) scores ≤ 1 before their events
were identified retrospectively from a large single-center stroke registry and
compared with age-matched and gender-matched controls. Antihypertensive use and
echocardiographic parameters including chamber volumes and left ventricular mass
and LA peak negative and positive strain and strain rate were compared between
groups. RESULTS: Fifty-seven patients meeting entry criteria were identified.
Patients demonstrated significantly lower left ventricular ejection fractions,
larger LA dimensions, and larger LA volume indexes (24.4 ± 11.9 vs 32.3 ± 13.3
mL/m(2), P = .012) compared with controls. Both peak negative LA strain (-3.2 ±
1.2% vs -6.9 ± 4.2%, P < .001) and peak positive LA strain (14 ± 11% vs 25 ± 12%, P
< .001) were significantly reduced in patients compared with controls. Peak
negative LA strain was significantly associated with stroke by binary logistic
regression (odds ratio, 2.15; P < .001). CONCLUSIONS: In patients with low-risk
CHADS(2) scores, atrial fibrillation, and stroke or TIA, reduced LA strain is a
potentially sensitive maker for increased risk for stroke or TIA. These results
suggest that LA strain may have potential as a tool for helping guide the decision
for or against oral anticoagulation in this group of patients.
AD - Henry Low Heart Center, Division of Cardiology, Hartford Hospital, Hartford,
Connecticut, USA.
AN - 23067897
AU - Azemi, T.
AU - Rabdiya, V. M.
AU - Ayirala, S. R.
AU - McCullough, L. D.
AU - Silverman, D. I.
DA - Dec
DO - 10.1016/j.echo.2012.09.004
DP - NLM
ET - 2012/10/17
IS - 12
J2 - Journal of the American Society of Echocardiography : official publication of
the American Society of Echocardiography
KW - Aged
Atrial Fibrillation/*diagnostic imaging/*epidemiology/physiopathology
Comorbidity
Connecticut/epidemiology
Elastic Modulus
Elasticity Imaging Techniques/statistics & numerical data
Female
Heart Atria/*diagnostic imaging/physiopathology
Humans
Incidence
Ischemic Attack, Transient/*diagnostic imaging/*epidemiology/physiopathology
Male
Registries
Reproducibility of Results
Risk Factors
Stroke/*diagnostic imaging/*epidemiology/physiopathology
LA - eng
N1 - 1097-6795
Azemi, Talhat
Rabdiya, Vimal M
Ayirala, Srilatha R
McCullough, Louise D
Silverman, David I
Journal Article
United States
J Am Soc Echocardiogr. 2012 Dec;25(12):1327-32. doi: 10.1016/j.echo.2012.09.004.
Epub 2012 Oct 12.
PY - 2012
SN - 0894-7317
SP - 1327-32
ST - Left atrial strain is reduced in patients with atrial fibrillation, stroke or
TIA, and low risk CHADS(2) scores
T2 - J Am Soc Echocardiogr
TI - Left atrial strain is reduced in patients with atrial fibrillation, stroke or
TIA, and low risk CHADS(2) scores
VL - 25
ID - 2397
ER -
TY - JOUR
AB - Cardioembolic stroke accounts for one third of all ischemic strokes, and
atrial fibrillation (AF) is the cardiac source of emboli in 50% of them. However,
the absolute risk of stroke associated with AF has enormous variability, and
several clinical risk stratification schemes have been proposed. One of the most
validated and used in clinical practice is the CHADS2 index, characterized by its
simplicity and rapid application. Current recommendations about antithrombotic
therapy in AF patients are based on assessment of annual risk of stroke; thus,
antiaggregation is indicated in patients with a low risk, and anticoagulation is
prescribed when annual risk is greater than 2.5%. Relevant studies comparing rate
and rhythm control do not defend achievement and maintenance of sinus rhythm as a
routine management of AF patients and demonstrate that rate control is comparable
or even better than rhythm control in terms of survival and quality of life.
Optimal control of blood pressure is a relevant factor in preventing cardioembolic
stroke in AF patients, because hypertension multiplies the risk of stroke by 12.
Antihypertensive drugs such as angiotensin-converting enzyme inhibitors and
angiotensin II receptor blockers proved to reduce AF recurrences, especially in the
context of left ventricular dysfunction and ventricular hypertrophy.
AD - Department of Cardiology, Hospital Clínico Universitario, Santiago de
Compostela, Spain.
AN - 19342836
AU - Babarro, E. G.
AU - Rego, A. R.
AU - González-Juanatey, J. R.
DO - 10.1159/000200444
DP - NLM
ET - 2009/04/15
J2 - Cerebrovascular diseases (Basel, Switzerland)
Antihypertensive Agents/therapeutic use
Atrial Fibrillation/complications/drug therapy
Cardiovascular Agents/*therapeutic use
Embolism/etiology/*prevention & control
Heart Diseases/complications/*drug therapy
Humans
Hypertension/complications/drug therapy
*Patient Care Team
Patient Selection
Practice Guidelines as Topic
Risk Assessment
Risk Factors
Secondary Prevention
Stroke/etiology/*prevention & control
Treatment Outcome
LA - eng
N1 - 1421-9786
Babarro, Eva González
Rego, Ana Román
González-Juanatey, José Ramón
Journal Article
Review
Switzerland
Cerebrovasc Dis. 2009;27 Suppl 1:82-7. doi: 10.1159/000200444. Epub 2009 Apr 3.
PY - 2009
SN - 1015-9770
SP - 82-7
ST - Cardioembolic stroke: call for a multidisciplinary approach
T2 - Cerebrovasc Dis
TI - Cardioembolic stroke: call for a multidisciplinary approach
VL - 27 Suppl 1
ID - 2521
ER -
TY - JOUR
AB - BACKGROUND: Late morbidity and mortality remain problematic after repair of
tetralogy of Fallot (TOF). We hypothesized that fibrosis detected by late
gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) would be
present in adults with repaired TOF and would be related to adverse markers of
outcome. METHOD AND RESULTS: LGE was scored in the right and left ventricles (RV
and LV) of 92 adult patients who had undergone TOF repair. RV LGE was seen in all
patients at surgical sites located in the outflow tract (99%) or the site of
ventricular septal defect patching (98%) and in the inferior RV insertion point
(79%) and trabeculated myocardium (24%). LV LGE (53%) was located at the apex
consistent with apical vent insertion (49%), in the inferior or lateral wall
consistent with infarction (5%), or in other areas (8%). Patients with supramedian
RV LGE score were older (38 versus 27 years, P<0.001) and more symptomatic (38%
versus 8% in New York Heart Association class II or greater, P=0.001), had
increased levels of atrial natriuretic peptide (7.3 versus 4.9 pmol/L, P=0.041),
and had a trend to higher brain natriuretic peptide (12.3 versus 7.2 pmol/L,
P=0.086), exercise intolerance (maximum VO2 24 versus 28 mL.min(-1).kg(-1),
P=0.021), RV dysfunction (RV end-systolic volume 61 versus 55 mL/m2, P=0.018; RV
ejection fraction 50% versus 56%, P=0.007), and clinical arrhythmia (26% versus
10%, P=0.039). Non-apical vent LV LGE also correlated with markers of adverse
outcome. In a multivariate model, RV LGE remained a predictor of arrhythmia.
CONCLUSIONS: RV and LV LGE were common after TOF repair and were related to adverse
clinical markers, including ventricular dysfunction, exercise intolerance, and
neurohormonal activation. Furthermore, RV LGE was significantly associated with
clinical arrhythmia.
AD - Adult Congenital Heart Unit, Royal Brompton Hospital, London SW3 6NP, United
Kingdom. sonya@doctors.org.uk
AN - 16432072
AU - Babu-Narayan, S. V.
AU - Kilner, P. J.
AU - Li, W.
AU - Moon, J. C.
AU - Goktekin, O.
AU - Davlouros, P. A.
AU - Khan, M.
AU - Ho, S. Y.
AU - Pennell, D. J.
AU - Gatzoulis, M. A.
DA - Jan 24
DP - NLM
ET - 2006/01/25
IS - 3
J2 - Circulation
KW - Adolescent
Adult
Arrhythmias, Cardiac/pathology
Child
Child, Preschool
Fibrosis
Gadolinium
Heart Diseases/*epidemiology/*pathology/surgery
Humans
Magnetic Resonance Imaging/*methods/standards
Middle Aged
Risk Factors
Tetralogy of Fallot/*epidemiology/*surgery
Treatment Outcome
Ventricular Dysfunction/pathology
LA - eng
N1 - 1524-4539
Babu-Narayan, Sonya V
Kilner, Philip J
Li, Wei
Moon, James C
Goktekin, Omer
Davlouros, Periklis A
Khan, Mohammed
Ho, Siew Yen
Pennell, Dudley J
Gatzoulis, Michael A
Journal Article
United States
Circulation. 2006 Jan 24;113(3):405-13. doi: 10.1161/CIRCULATIONAHA.105.548727.
PY - 2006
SN - 0009-7322
SP - 405-13
ST - Ventricular fibrosis suggested by cardiovascular magnetic resonance in adults
with repaired tetralogy of fallot and its relationship to adverse markers of
clinical outcome
T2 - Circulation
TI - Ventricular fibrosis suggested by cardiovascular magnetic resonance in adults
with repaired tetralogy of fallot and its relationship to adverse markers of
clinical outcome
VL - 113
ID - 2873
ER -
TY - JOUR
AB - The incidence and the nature of medium-term complications of automatic
implantable cardiac defibrillators (AICD) were studied. Seventy-nine AICD were
implanted in 50 consecutive patients (42 men, aged 54.5 +/- 13.7 years). Forty-six
patients had spontaneous ventricular arrhythmia. These arrhythmias were resistant
to treatment (N = 9), reproducible with treatment (N = 28). In 4 patients, the
indication was prophylactic, in 2 a Brugada syndrome, in 2 syncope with reinducible
ventricular tachycardia and in 1 patient, torsades with a short coupling interval.
Forty-six patients had underlying cardiac disease (ischaemic, N = 28, primary
dilated cardiomyopathy, N = 10, others, N = 8). The ejection fraction was > 40% in
32 patients. The average follow-up was 41.3 +/- 34.9 months. Eight patients died, 2
from cardiac failure. Twenty-one patients (42%) had 1 or more complications related
to their AICD. These occurred: in the operative period (N = 3): 1 post-shock
atrioventricular block, 1 ruptured electrode and 1 increased threshold with
amiodarone; in the postoperative period (N = 6): infection in 3 cases,
cerebrovascular accident in 1 case, deep venous thrombosis of the left arm in 1
case, pneumothorax in 1 case. In the medium-term, the complications were mainly
inappropriate electrical shocks observed in 14 patients related to atrial
arrhythmias in 7 cases, sinus tachycardia in 1 case, over-detection of
myopotentials in 2 cases and electrode dysfunction in 4 cases. In addition, the
authors observed complications related to the material: AICD failure in 1 case,
electrode displacement in 1 case, and electrode rupture in 3 cases. The authors
conclude that AICD are effective for the treatment of malignant ventricular
arrhythmias which justify strict specialist follow-up given the incidence and
diversity of their complications.
AD - Service de chirurgie cardiaque, centre hospitalier universitaire Trousseau,
37044 Tours.
AN - 11190454
AU - Babuty, D.
AU - Fauchier, L.
AU - Charniot, J. C.
AU - Grimbert, M.
AU - Tena-Carbi, D.
AU - Poret, P.
AU - Neville, P.
AU - Fauchier, J. P.
AU - Cosnay, P.
DA - Nov
DP - NLM
ET - 2001/02/24
IS - 11
KW - Adult
Aged
Cause of Death
Defibrillators, Implantable/*adverse effects
Female
Follow-Up Studies
Humans
Incidence
Male
Middle Aged
Stroke/etiology
Venous Thrombosis/etiology
Ventricular Fibrillation/*therapy
LA - fre
N1 - Babuty, D
Fauchier, L
Charniot, J C
Grimbert, M
Tena-Carbi, D
Poret, P
Neville, P
Fauchier, J P
Cosnay, P
English Abstract
Journal Article
France
Arch Mal Coeur Vaiss. 2000 Nov;93(11):1269-75.
OP - Complications à moyen terme du défibrillateur cardiaque automatique
implantable.
PY - 2000
SN - 0003-9683 (Print)
0003-9683
SP - 1269-75
ST - [Mid-term complications of automatic implantable cardiac defibrillators]
TI - [Mid-term complications of automatic implantable cardiac defibrillators]
VL - 93
ID - 2684
ER -
TY - JOUR
AB - BACKGROUND: With an increasing awareness of health issues and greater
emphasis on preventive medicine, the general population is living longer and
healthier lives than ever before. Physicians are taking care of older patients,
many of whom may require cardiac surgical procedures. Improving cardiopulmonary
bypass technology allows for safer procedures with reduced morbidity and mortality
even in older patients. METHODS: We have performed a retrospective analysis of 42
consecutive nonagenarian patients who underwent open-heart procedures over a 10-
year period (1993 to 2002) at our institution. Their demographic profiles,
operative data, perioperative results, and long-term outcomes were recorded and
analyzed. RESULTS: Twenty-two women and 20 men with an age range of 90 to 97 years
(mean, 91.4 years) had open-heart surgery over the study period. The complication
rate was 67% overall, consisting of 7% respiratory (pneumonia, respiratory failure,
reintubation), 7% hemorrhagic or embolic (postoperative bleeding, cerebral vascular
accident), 12% infectious (wound infection, sepsis), and 31% new arrhythmia (atrial
fibrillation, atrial flutter, ventricular tachycardia, ventricular fibrillation).
Despite these complication rates, average hospital stay was 17.5 days (median, 11
days), with an intensive care unit stay of 12.0 days (median, 5 days). Thirty-day
survival was 95% and survival to discharge was 93% (three deaths total; one cardiac
arrest at hospital day 134 and two perioperative deaths; one ventricular
arrhythmia, one cerebral vascular accident). The only statistically significant
risk factor of mortality was emergency surgery. Currently, 81% are still alive an
average of 2.53 years since surgery (range, 0.16 to 7.1 years). CONCLUSIONS: With
improving techniques and greater attention to detail, the select nonagenarian can
safely undergo cardiac surgery.
AD - Department of Cardiothoracic Surgery, New York Presbyterian Hospital-Cornell
University Medical College, New York, New York 10021, USA.
AN - 12683566
AU - Bacchetta, M. D.
AU - Ko, W.
AU - Girardi, L. N.
AU - Mack, C. A.
AU - Krieger, K. H.
AU - Isom, O. W.
AU - Lee, L. Y.
DA - Apr
DO - 10.1016/s0003-4975(02)04666-0
DP - NLM
ET - 2003/04/10
IS - 4
KW - Age Factors
Aged
Aged, 80 and over
*Cardiac Surgical Procedures
Cardiopulmonary Bypass
Emergencies
Female
Humans
Intensive Care Units
Length of Stay
Male
Treatment Outcome
LA - eng
N1 - Bacchetta, Matthew D
Ko, Wilson
Girardi, Leonard N
Mack, Charles A
Krieger, Karl H
Isom, O Wayne
Lee, Leonard Y
Journal Article
Review
Netherlands
Ann Thorac Surg. 2003 Apr;75(4):1215-20. doi: 10.1016/s0003-4975(02)04666-0.
PY - 2003
SN - 0003-4975 (Print)
0003-4975
SP - 1215-20
ST - Outcomes of cardiac surgery in nonagenarians: a 10-year experience
TI - Outcomes of cardiac surgery in nonagenarians: a 10-year experience
VL - 75
ID - 3070
ER -
TY - JOUR
AB - Almost 50% of patients with congestive heart failure (HF) have preserved
ejection fraction (PEF). Data on the effect of HF-PEF on atrial fibrillation
outcomes are lacking. We assessed the prognostic significance of HF-PEF in an
atrial fibrillation population compared to a systolic heart failure (SHF)
population. A post hoc analysis of the National Heart, Lung, and Blood Institute-
limited access data set of the Atrial Fibrillation Follow-up Investigation of
Rhythm Management (AFFIRM) trial was carried out. The patients with a history of
congestive HF and a preserved ejection fraction (EF >50%) were classified as having
HF-PEF (n = 320). The patients with congestive HF and a qualitatively depressed EF
(EF <50%) were classified as having SHF (n = 402). Cox proportional hazards
analysis was performed. The mean follow-up duration was 1,181 ± 534 days/patient.
The patients with HF-PEF had lower all-cause mortality (hazard ratio [HR] 0.62, 95%
confidence interval [CI] 0.46 to 0.85, p = 0.003) and cardiovascular mortality (HR
0.56, 95% CI 0.38 to 0.84, p = 0.006), with a possible decreased arrhythmic end
point (HR 0.39, 95% CI 0.16 to 1.006, p = 0.052) than did the patients with SHF. No
differences were observed for ischemic stroke (HR 1.08, 95% CI 0.48 to 2.39, p =
0.86), rehospitalization (HR 0.89, 95% CI 0.75 to 1.07, p = 0.24), or progression
to New York Heart Association class III-IV (odds ratio 0.80, 95% CI 0.42 to 1.54, p
= 0.522). In conclusion, although patients with HF-PEF have better mortality
outcomes than those with SHF, the morbidity appears to be similar.
AD - Department of Internal Medicine, Wayne State University School of Medicine,
Detroit, Michigan, USA.
AN - 21855829
AU - Badheka, A. O.
AU - Rathod, A.
AU - Kizilbash, M. A.
AU - Bhardwaj, A.
AU - Ali, O.
AU - Afonso, L.
AU - Jacob, S.
DA - Nov 1
DO - 10.1016/j.amjcard.2011.06.045
DP - NLM
ET - 2011/08/23
IS - 9
KW - Age Factors
Aged
Atrial Fibrillation/*epidemiology
Disease Progression
Female
Heart Failure/*epidemiology
Humans
Hypertension/epidemiology
Male
Patient Readmission
Prognosis
Sex Factors
Stroke/epidemiology
*Stroke Volume
LA - eng
N1 - 1879-1913
Badheka, Apurva O
Rathod, Ankit
Kizilbash, Mohammad A
Bhardwaj, Aditya
Ali, Omaima
Afonso, Luis
Jacob, Sony
Comparative Study
Journal Article
United States
Am J Cardiol. 2011 Nov 1;108(9):1283-8. doi: 10.1016/j.amjcard.2011.06.045. Epub
2011 Aug 18.
PY - 2011
SN - 0002-9149
SP - 1283-8
ST - Comparison of mortality and morbidity in patients with atrial fibrillation
and heart failure with preserved versus decreased left ventricular ejection
fraction
T2 - Am J Cardiol
TI - Comparison of mortality and morbidity in patients with atrial fibrillation
and heart failure with preserved versus decreased left ventricular ejection
fraction
VL - 108
ID - 2637
ER -
TY - JOUR
AB - Amiodarone has been proposed to decrease atrial fibrillation after cardiac
surgery. The literature was systematically reviewed for randomized trials comparing
amiodarone with control for prevention of atrial fibrillation. Data were extracted
on study characteristics, quality, and incidence of atrial fibrillation,
cardiovascular outcomes, and length of hospitalization. Nineteen trials were
included. Amiodarone reduced the odds ratio of atrial fibrillation (0.50; 95%
confidence interval [CI]: 0.43 to 0.59, p < 0.0001), ventricular tachyarrhythmias
(0.39; 95% CI: 0.26 to 0.58, p < 0.0001), and strokes (0.53; 95% CI: 0.30 to 0.92,
p = 0.02). Amiodarone reduced hospital stay (0.6 days; 95% CI: 0.4 to 0.8, p <
0.0001). Amiodarone decreased atrial fibrillation, reduced perioperative
ventricular tachyarrhythmias and strokes, and reduced duration of hospitalization.
The current evidence supports recommending the routine use of perioperative
amiodarone for cardiac surgery.
AD - Department of Critical Care Medicine, University of Calgary, Calgary,
Alberta, Canada; Department of Community Health Sciences, University of Calgary,
Calgary, Alberta, Canada; Department of Intensive Care, Austin Hospital, Melbourne,
Victoria, Australia.
AN - 17062287
AU - Bagshaw, S. M.
AU - Galbraith, P. D.
AU - Mitchell, L. B.
AU - Sauve, R.
AU - Exner, D. V.
AU - Ghali, W. A.
DA - Nov
DO - 10.1016/j.athoracsur.2006.06.032
DP - NLM
ET - 2006/10/26
IS - 5
KW - Adrenergic beta-Antagonists/therapeutic use
Amiodarone/*therapeutic use
Atrial Fibrillation/epidemiology/etiology/*prevention & control
Chemoprevention
Humans
Incidence
Length of Stay
LA - eng
N1 - 1552-6259
Bagshaw, Sean M
Galbraith, P Diane
Mitchell, L Brent
Sauve, Reg
Exner, Derek V
Ghali, William A
Journal Article
Meta-Analysis
Review
Netherlands
Ann Thorac Surg. 2006 Nov;82(5):1927-37. doi: 10.1016/j.athoracsur.2006.06.032.
PY - 2006
SN - 0003-4975
SP - 1927-37
ST - Prophylactic amiodarone for prevention of atrial fibrillation after cardiac
surgery: a meta-analysis
TI - Prophylactic amiodarone for prevention of atrial fibrillation after cardiac
surgery: a meta-analysis
VL - 82
ID - 2639
ER -
TY - JOUR
AB - Lead wire malposition is a known, but rare complication of permanent
pacemaker or defibrillator implantation. The actual incidence and prevalence is
unknown and management options for inadvertent left ventricular lead malposition
have not been uniform. Current recommendations include systemic anticoagulation
with warfarin or surgical lead removal with circulatory arrest for compelling
clinical scenarios. Percutaneous left-sided lead extraction is contraindicated due
to the potentially increased risk of thromboembolic complications associated with
this procedure. To our knowledge, this is the first report of percutaneous
extraction of inadvertently placed left ventricular and left atrial endocardial
pacemaker leads with flow-preserving complete cerebral embolic protection. We also
review the current literature regarding the incidence, management, and percutaneous
extraction of left-sided cardiac leads.
AD - Division of Cardiovascular Medicine and Sulpizio Cardiovascular Center,
University of California, San Diego, California.
AN - 25581608
AU - Bahadorani, J. N.
AU - Schricker, A. A.
AU - Pretorius, V. G.
AU - Birgersdotter-Green, U.
AU - Dominguez, A.
AU - Mahmud, E.
DA - Oct
DO - 10.1002/ccd.25826
DP - NLM
ET - 2015/01/13
IS - 4
J2 - Catheterization and cardiovascular interventions : official journal of the
Society for Cardiac Angiography & Interventions
KW - Aged
Device Removal/*methods
Electrodes, Implanted
Embolic Protection Devices/*statistics & numerical data
Endovascular Procedures/methods
*Equipment Failure
Follow-Up Studies
Humans
Intracranial Embolism/*prevention & control
Male
Pacemaker, Artificial/*adverse effects
Risk Assessment
Sick Sinus Syndrome/diagnostic imaging/*therapy
Treatment Outcome
cerebral embolic protection
distal embolic protection device
lead wire malposition
percutaneous lead extraction
LA - eng
N1 - 1522-726x
Bahadorani, John N
Schricker, Amir A
Pretorius, Victor G
Birgersdotter-Green, Ulrika
Dominguez, Arturo
Mahmud, Ehtisham
Case Reports
Journal Article
United States
Catheter Cardiovasc Interv. 2015 Oct;86(4):777-85. doi: 10.1002/ccd.25826. Epub
2015 Feb 12.
PY - 2015
SN - 1522-1946
SP - 777-85
ST - Percutaneous extraction of inadvertently placed left-sided pacemaker leads
with complete cerebral embolic protection
T2 - Catheter Cardiovasc Interv
TI - Percutaneous extraction of inadvertently placed left-sided pacemaker leads
with complete cerebral embolic protection
VL - 86
ID - 2904
ER -
TY - JOUR
AB - BACKGROUND: Brain natriuretic peptide (BNP) is increasingly being used for
screening and monitoring of congestive heart failure. However, the role of BNP in
patients with atrial fibrillation (AF) and normal left ventricular function has not
been determined. This study investigates serum N-terminal pro-brain natriuretic
peptide (NT-proBNP) level and its clinical implications in patients with AF.
METHODS: Serum NT-proBNP levels were measured by enzyme-linked immunosorbent assay
(ELISA) and transthoracic echocardiography was performed in 136 subjects (90 cases
with AF and 46 cases with sinus rhythm [SR]). Subjects were excluded if they had a
history of myocardial infarction, cardiomyopathy, rheumatic heart disease, or
hyperthyroidism that preceded the onset of AF. Controls (n = 30) were from a
healthy outpatient primary care population. Potential determinants of serum NT-
proBNP levels were identified by univariate and multivariate analyses. RESULTS:
Individuals with AF had higher serum NT-proBNP levels (689.56 +/- 251.87 fmol/ml)
than those with SR (456.11 +/- 148.14 fmol/ml, P < 0.01) and control subjects
(415.83 +/- 62.02 fmol/ml, P < 0.01). Individuals with SR and control subjects did
not show significant difference at serum NT-proBNP levels (P > 0.05). The
regression model of serum NT-proBNP levels and clinical predictors showed that
presence of AF, older age, and larger right atrial diameter were independently
predictive of higher serum NT-proBNP values. CONCLUSIONS: Patients with AF were
associated with increased serum NT-proBNP levels. Examining the change of serum NT-
proBNP levels is helpful to evaluate the cardiac function in patients with AF.
AD - Department of Cardiology, Beijing Hospital, Chinese Academy of Medical
Sciences and Peking Union Medical College, Beijing, China.
AN - 20014208
AU - Bai, M.
AU - Yang, J.
AU - Li, Y.
C2 - PMC6653281
DA - Dec
DO - 10.1002/clc.20478
DP - NLM
ET - 2009/12/17
IS - 12
J2 - Clinical cardiology
Age Factors
Aged
Atrial Fibrillation/*blood
Echocardiography
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
Middle Aged
Stroke Volume
LA - eng
N1 - 1932-8737
Bai, Mei
Yang, Jiefu
Li, Yingying
Journal Article
Clin Cardiol. 2009 Dec;32(12):E1-5. doi: 10.1002/clc.20478.
PY - 2009
SN - 0160-9289 (Print)
0160-9289
SP - E1-5
ST - Serum N-terminal-pro-brain natriuretic peptide level and its clinical
implications in patients with atrial fibrillation
T2 - Clin Cardiol
TI - Serum N-terminal-pro-brain natriuretic peptide level and its clinical
implications in patients with atrial fibrillation
VL - 32
ID - 3039
ER -
TY - JOUR
AB - INTRODUCTION: Atrial fibrillation (AF) is the most common, sustained rhythm
disturbance. The prevalence of AF is increasing as people live longer. Common
conditions such as hypertension and ischaemic heart disease play an important role
in the development of AF. The presence of AF is associated with increased morbidity
and mortality from stroke and heart failure, particularly in patients with
structural heart disease. SOURCES OF DATA: This article provides evidence-based
information on the key aspects of managing AF which is based on major guidelines,
landmark clinical trials and meta-analyses. AREAS OF AGREEMENT: It is well
recognized that both rate control and rhythm control are important strategies for
the management of AF, but each approach should be chosen according to individual
patient circumstances. A vast majority of elderly, relatively asymptomatic patients
will benefit from ventricular rate control. Embolic stroke remains a major
complication of AF. Yet, anticoagulation with warfarin remains underprescribed,
especially in the elderly due to the presumed risk of bleeding. The technique of
catheter ablation continues to improve and is generally successful in younger
patients with relatively normal hearts. AREAS OF CONTROVERSY: There are clinically
relevant differences among published schemes designed to stratify stroke risk in
patients with AF. The CHADS2 score is currently the most simple system to give some
initial estimate of stroke risk in AF patients, but could significantly
underestimate this risk, particularly in those who fall in the 'intermediate' risk
category. GROWING POINTS AND AREAS TIMELY FOR DEVELOPING RESEARCH: Novel
antiarrhythmic agents, including atrial specific agents with improved efficacy and
safety profile, are currently under development. New antithrombotic agents with
efficacy similar to warfarin which do not require regular INR testing appear to be
promising, but there are lack of data about their long-term safety. There is
increasing evidence that inflammation and fibrosis may play a major role in the
initiation and maintenance of AF. Statins by means of their pleotropic effects and
angiotensin-converting enzyme inhibitors and angiotensin receptor blockers by
preventing atrial remodelling may prove useful in preventing the development of AF.
However, there is insufficient evidence to expand the use of these agents to a
wider patient population at risk of AF. It needs to be seen if strategies towards
primary and secondary prevention with treatment of underlying heart disease and
modification of risk factors have a larger effect than specific interventions in
preventing the burden of AF in the general population.
AD - Ground Floor, Jenner Wing, St George's, University of London, Cranmer
Terrace, Tooting, London SW170RE, UK.
AN - 19059992
AU - Bajpai, A.
AU - Savelieva, I.
AU - Camm, A. J.
DO - 10.1093/bmb/ldn046
DP - NLM
ET - 2008/12/09
IS - 1
J2 - British medical bulletin
KW - Adult
Aged
Aged, 80 and over
Atrial Fibrillation/complications/*drug therapy/physiopathology
Female
Heart Atria/physiopathology
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use
Male
Middle Aged
Myocardial Ischemia/*etiology/prevention & control
Risk Factors
Stroke/*etiology/prevention & control
LA - eng
N1 - 1471-8391
Bajpai, Abhay
Savelieva, Irina
Camm, A John
Journal Article
Review
England
Br Med Bull. 2008;88(1):75-94. doi: 10.1093/bmb/ldn046. Epub 2008 Dec 5.
PY - 2008
SN - 0007-1420
SP - 75-94
ST - Treatment of atrial fibrillation
T2 - Br Med Bull
TI - Treatment of atrial fibrillation
VL - 88
ID - 2418
ER -
TY - JOUR
AB - OBJECTIVE: Women with congenital heart disease (CHD) are at risk for adverse
cardiac events during pregnancy; however, the risk of events late after pregnancy
(late cardiac events; LCE) has not been well studied. A study was undertaken to
examine the frequency and determinants of LCE in a large cohort of women with CHD.
DESIGN: Baseline characteristics and pregnancy were prospectively recorded. LCE
(>6months after delivery) were determined by chart review. Survival analysis was
used to determine the risk factors for LCE. SETTING: A tertiary care referral
hospital. PATIENTS: The outcomes of 405 pregnancies were studied (318 women; median
follow-up 2.6&emsp14;years). MAIN OUTCOME MEASURES: LCE included cardiac
death/arrest, pulmonary oedema, arrhythmia or stroke. RESULTS: LCE occurred after
12% (50/405) of pregnancies. The 5-year rate of LCE was higher in women with
adverse cardiac events during pregnancy than in those without (27±9% vs 15±3%, HR
2.2, p=0.02). Women at highest risk for LCE were those with functional
limitations/cyanosis (HR 3.9, 95% CI 1.2 to 13.0), subaortic ventricular
dysfunction (HR 3.0, 95% CI 1.4 to 6.6), subpulmonary ventricular dysfunction
and/or significant pulmonary regurgitation (HR 3.2, 95% CI 1.6 to 6.6), left heart
obstruction (HR 2.6, 95% CI 1.2 to 5.2) and cardiac events before or during
pregnancy (HR 2.6, 95% CI 1.3 to 4.9). In women with 0, 1 or >1 risk predictors the
5-year rate of LCE was 7±2%, 23±5% and 44±10%, respectively (p<0.001). CONCLUSIONS:
In women with CHD, pre-pregnancy maternal characteristics can help to identify
women at increased risk for LCE. Adverse cardiac events during pregnancy are
important and are associated with an increased risk of LCE.
AD - University of Toronto Pregnancy and Heart Disease Research Program, Mount
Sinai and Toronto General Hospitals, Toronto, Ontario, Canada.
AN - 20937754
AU - Balint, O. H.
AU - Siu, S. C.
AU - Mason, J.
AU - Grewal, J.
AU - Wald, R.
AU - Oechslin, E. N.
AU - Kovacs, B.
AU - Sermer, M.
AU - Colman, J. M.
AU - Silversides, C. K.
DA - Oct
DO - 10.1136/hrt.2010.202838
DP - NLM
ET - 2010/10/13
IS - 20
J2 - Heart (British Cardiac Society)
KW - Adult
Arrhythmias, Cardiac/etiology
Death, Sudden, Cardiac/etiology
Female
Heart Defects, Congenital/*complications/diagnosis
Humans
Maternal Age
Parity
Pregnancy
Pregnancy Complications, Cardiovascular/*diagnosis
Pregnancy Outcome
Prognosis
Pulmonary Edema/etiology
Stroke/etiology
Young Adult
LA - eng
N1 - 1468-201x
Balint, Olga H
Siu, Samuel C
Mason, Jennifer
Grewal, Jasmine
Wald, Rachel
Oechslin, Erwin N
Kovacs, Brigitte
Sermer, Mathew
Colman, Jack M
Silversides, Candice K
53030/Canadian Institutes of Health Research/Canada
Journal Article
England
Heart. 2010 Oct;96(20):1656-61. doi: 10.1136/hrt.2010.202838.
PY - 2010
SN - 1355-6037
SP - 1656-61
ST - Cardiac outcomes after pregnancy in women with congenital heart disease
T2 - Heart
TI - Cardiac outcomes after pregnancy in women with congenital heart disease
VL - 96
ID - 2447
ER -
TY - JOUR
AB - OBJECTIVES: This study assessed trends in transesophageal echocardiography
(TEE) use, rate of left atrial appendage (LAA) thrombus detection, and incidence of
periprocedural cerebrovascular accident (CVA) since transitioning to a strategy of
uninterrupted warfarin or briefly interrupted novel oral anticoagulant therapy
in 2010. BACKGROUND: TEE is routinely performed before ablation for atrial
fibrillation (AF) to ensure absence of LAA thrombus. METHODS: Patients with AF
ablation presenting between January 2010 and September 2015 at Johns Hopkins
Hospital were enrolled in an AF ablation registry; TEE and ablation outcomes were
retrospectively analyzed. Presence of LAA thrombus, dense spontaneous echo contrast
(SEC), or patent foramen ovale (PFO) were recorded. CVA incidence from procedure
onset to 30 days post-procedure was evaluated using electronic medical record
review. RESULTS: Pre-procedure TEE was performed in 646 of 1,224 AF ablation cases
(52.8%). There was a decline in pre-procedure TEE use from 86% in 2010 to 42% in
2015 (p < 0.001). CVA incidence was 4/1,224 (0.33%) cases, and did not change
during the study period. TEE findings included LAA thrombus (n = 6; 0.93%), PFO
(n = 23; 3.6%), and dense spontaneous echo contrast (n = 99; 15.3%). Both SEC and
LAA thrombus were associated with persistent AF, higher CHA(2)DS(2)VASC score,
increased LA size, reduced LAA flow velocity, and decreased left ventricular
ejection fraction. PFO was not associated with prior AF ablation, and SEC was not
associated with increased CVA incidence. CONCLUSIONS: CVA is a rare complication of
AF ablation in patients with minimally interrupted anticoagulation. Pre-ablation
TEE may be reasonably avoided in patients without high-risk features.
AD - Johns Hopkins Hospital Heart and Vascular Institute, Baltimore, Maryland.
Johns Hopkins Hospital Heart and Vascular Institute, Baltimore, Maryland.
Electronic address: dspragg1@jhmi.edu.
AN - 29759444
AU - Balouch, M.
AU - Gucuk Ipek, E.
AU - Chrispin, J.
AU - Bajwa, R. J.
AU - Zghaib, T.
AU - Berger, R. D.
AU - Ashikaga, H.
AU - Calkins, H.
AU - Nazarian, S.
AU - Marine, J. E.
AU - Spragg, D. D.
DA - Apr
DO - 10.1016/j.jacep.2016.09.011
DP - NLM
ET - 2018/05/16
IS - 4
J2 - JACC. Clinical electrophysiology
KW - Aged
Atrial Fibrillation/*surgery
Catheter Ablation/*adverse effects
Echocardiography, Transesophageal/*statistics & numerical data
Female
Humans
Male
Middle Aged
Registries
Stroke/*diagnostic imaging/epidemiology/etiology
Thrombosis/epidemiology/prevention & control
Treatment Outcome
*ablation
*atrial fibrillation
*transesophageal echocardiography
LA - eng
N1 - 2405-5018
Balouch, Muhammad
Gucuk Ipek, Esra
Chrispin, Jonathan
Bajwa, Rizma J
Zghaib, Tarek
Berger, Ronald D
Ashikaga, Hiroshi
Calkins, Hugh
Nazarian, Saman
Marine, Joseph E
Spragg, David D
Journal Article
United States
JACC Clin Electrophysiol. 2017 Apr;3(4):329-336. doi: 10.1016/j.jacep.2016.09.011.
Epub 2016 Nov 23.
PY - 2017
SN - 2405-500x
SP - 329-336
ST - Trends in Transesophageal Echocardiography Use, Findings, and Clinical
Outcomes in the Era of Minimally Interrupted Anticoagulation for Atrial
Fibrillation Ablation
T2 - JACC Clin Electrophysiol
TI - Trends in Transesophageal Echocardiography Use, Findings, and Clinical
Outcomes in the Era of Minimally Interrupted Anticoagulation for Atrial
Fibrillation Ablation
VL - 3
ID - 2513
ER -
TY - JOUR
AB - OBJECTIVE: We sought to determine the impact of preoperative or postoperative
atrial fibrillation on survival, stroke, and cardiac function after mitral
valvuloplasty for mitral regurgitation. METHODS: Between 1991 and 2003, 1026
patients with nonischemic/noncardiomyopathy mitral valve regurgitation underwent
mitral valve plasty in 3 centers; 663 patients remained in sinus rhythm (group A),
and 363 patients had atrial fibrillation or flutter preoperatively (group B) with
concomitant maze procedures (group BM, n = 163) or without maze procedures (group
BN, n = 200). RESULTS: Eight-year freedom from cardiovascular-related death was
better in group A (99.3%) than group B (BM: 96.9%, BN: 81.6%) ( P < .001) and also
better in group BM than group BN ( P = .007). The adjusted hazard ratio of group B
versus group A for preoperative differences was 5.1 (95% confidence interval: 1.8-
14.8). Eight-year freedom from stroke was better in group A (99.2%) than group B
(BM: 98.2%, BN: 82.6%) ( P < .001) and also better in group BM than group BN ( P
< .001). Patients with preoperative atrial fibrillation had larger left atria and
left ventricular systolic dimensions. The adjunct maze procedure improved left
ventricular systolic dimensions over mitral repair alone (group A vs B: P = .359;
group BM vs BN: P = .001). CONCLUSION: Preoperative permanent/persistent atrial
fibrillation was associated with a dilated left atrium and reduced left ventricular
function in patients with mitral regurgitation. Including the maze procedure with
mitral repair improved survival, late cardiac function, and freedom from late
stroke.
AD - Department of Cardiovascular Surgery, National Cardiovascular Center, 5-7-1
Fujishirodai, Suita, Osaka 565-8565, Japan. kobando@hsp.ncvc.go.jp
AN - 15867777
AU - Bando, K.
AU - Kasegawa, H.
AU - Okada, Y.
AU - Kobayashi, J.
AU - Kada, A.
AU - Shimokawa, T.
AU - Nasu, M.
AU - Nakatani, S.
AU - Niwaya, K.
AU - Tagusari, O.
AU - Nakajima, H.
AU - Hirata, M.
AU - Yagihara, T.
AU - Kitamura, S.
DA - May
DO - 10.1016/j.jtcvs.2004.10.037
DP - NLM
ET - 2005/05/04
IS - 5
J2 - The Journal of thoracic and cardiovascular surgery
KW - Actuarial Analysis
Adult
Aged
Atrial Flutter/*complications
Catheterization/adverse effects/*methods/mortality
Female
Follow-Up Studies
Humans
Incidence
Japan/epidemiology
Male
Middle Aged
Mitral Valve Insufficiency/complications/diagnostic imaging/*therapy
Morbidity
Recurrence
Stroke/epidemiology/etiology
Survival Analysis
Treatment Outcome
Ultrasonography
Ventricular Dysfunction, Left/etiology
LA - eng
N1 - Bando, Ko
Kasegawa, Hitoshi
Okada, Yukikatsu
Kobayashi, Junjiro
Kada, Akiko
Shimokawa, Tomoki
Nasu, Michinori
Nakatani, Satoshi
Niwaya, Kazuo
Tagusari, Osamu
Nakajima, Hiroyuki
Hirata, Mitsuhiro
Yagihara, Toshikatsu
Kitamura, Soichiro
Journal Article
United States
J Thorac Cardiovasc Surg. 2005 May;129(5):1032-40. doi:
10.1016/j.jtcvs.2004.10.037.
PY - 2005
SN - 0022-5223 (Print)
0022-5223
SP - 1032-40
ST - Impact of preoperative and postoperative atrial fibrillation on outcome after
mitral valvuloplasty for nonischemic mitral regurgitation
T2 - J Thorac Cardiovasc Surg
TI - Impact of preoperative and postoperative atrial fibrillation on outcome after
mitral valvuloplasty for nonischemic mitral regurgitation
VL - 129
ID - 2585
ER -
TY - JOUR
AB - BACKGROUND: Lipid-lowering drugs, particularly statins, have anti-
inflammatory and antioxidant properties that may prevent atrial fibrillation (AF).
This effect has not been investigated on new-onset AF in asymptomatic patients with
aortic stenosis (AS). METHODS: Asymptomatic patients with mild-to-moderate AS (n =
1,421) were randomized (1:1) to double-blind simvastatin 40 mg and ezetimibe 10 mg
combination or placebo and followed up for a mean of 4.3 years. The primary end
point was the time to new-onset AF adjudicated by 12-lead electrocardiogram at a
core laboratory reading center. Secondary outcomes were the correlates of new-onset
AF with nonfatal nonhemorrhagic stroke and a combined end point of AS-related
events. RESULTS: During the course of the study, new-onset AF was detected in 85
(6%) patients (14.2/1,000 person-years of follow-up). At baseline, patients who
developed AF were, compared with those remaining in sinus rhythm, older and had a
higher left ventricular mass index a smaller aortic valve area index. Treatment
with simvastatin and ezetimibe was not associated with less new-onset AF (odds
ratio 0.89 [95% CI 0.57-1.97], P = .717). In contrast, age (hazard ratio [HR] 1.07
[95% CI 1.05-1.10], P < .001) and left ventricular mass index (HR 1.01 [95% CI
1.01-1.02], P < .001) were independent predictors of new-onset AF. The occurrence
of new-onset AF was independently associated with 2-fold higher risk of AS-related
outcomes (HR 1.65 [95% CI 1.02-2.66], P = .04) and 4-fold higher risk of nonfatal
nonhemorrhagic stroke (HR 4.04 [95% CI 1.18-13.82], P = .03). CONCLUSIONS:
Simvastatin and ezetimibe were not associated with less new-onset AF. Older age and
greater left ventricular mass index were independent predictors of AF development.
New-onset AF was associated with a worsening of prognosis.
AD - Department of Cardiology, The Heart Center, Rigshospitalet, Copenhagen,
Denmark. casperbang@hotmail.com
AN - 22520536
AU - Bang, C. N.
AU - Greve, A. M.
AU - Boman, K.
AU - Egstrup, K.
AU - Gohlke-Baerwolf, C.
AU - Køber, L.
AU - Nienaber, C. A.
AU - Ray, S.
AU - Rossebø, A. B.
AU - Wachtell, K.
DA - Apr
DO - 10.1016/j.ahj.2012.01.026
DP - NLM
ET - 2012/04/24
IS - 4
J2 - American heart journal
KW - Aged
Aged, 80 and over
Anticholesteremic Agents/*therapeutic use
Aortic Valve Stenosis/*complications
Atrial Fibrillation/diagnostic imaging/epidemiology/etiology/pathology/*prevention
&
control
Azetidines/*therapeutic use
Double-Blind Method
Ezetimibe
Female
Heart Ventricles/pathology
Humans
Male
Middle Aged
Prognosis
Simvastatin/*therapeutic use
Stroke/epidemiology
Time Factors
Ultrasonography
LA - eng
N1 - 1097-6744
Bang, Casper N
Greve, Anders M
Boman, Kurt
Egstrup, Kenneth
Gohlke-Baerwolf, Christa
Køber, Lars
Nienaber, Christoph A
Ray, Simon
Rossebø, Anne B
Wachtell, Kristian
Journal Article
Multicenter Study
United States
Am Heart J. 2012 Apr;163(4):690-6. doi: 10.1016/j.ahj.2012.01.026.
PY - 2012
SN - 0002-8703
SP - 690-6
ST - Effect of lipid lowering on new-onset atrial fibrillation in patients with
asymptomatic aortic stenosis: the Simvastatin and Ezetimibe in Aortic Stenosis
(SEAS) study
T2 - Am Heart J
TI - Effect of lipid lowering on new-onset atrial fibrillation in patients with
asymptomatic aortic stenosis: the Simvastatin and Ezetimibe in Aortic Stenosis
(SEAS) study
VL - 163
ID - 2537
ER -
TY - JOUR
AB - BACKGROUND: Atrial fibrillation (AF), the most common sustained arrhythmia in
CKD, is associated with poor clinical outcomes in both patients without CKD and
patients with dialysis-treated ESRD. However, less is known about AF-associated
outcomes in patients with CKD who do not require dialysis. METHODS: To
prospectively examine the association of new-onset AF with subsequent risks of
cardiovascular disease events and death among adults with CKD, we studied
participants enrolled in the Chronic Renal Insufficiency Cohort Study who did not
have AF at baseline. Outcomes included heart failure, myocardial infarction,
stroke, and death occurring after diagnosis of AF. We used Cox regression models
and marginal structural models to examine the association of incident AF with
subsequent risk of cardiovascular disease events and death, adjusting for patient
characteristics, laboratory values, and medication use. RESULTS: Among 3080
participants, 323 (10.5%) developed incident AF during a mean 6.1 years of follow-
up. Compared with participants who did not develop AF, those who did had higher
adjusted rates of heart failure (hazard ratio [HR], 5.17; 95% confidence interval
[95% CI], 3.89 to 6.87), myocardial infarction (HR, 3.64; 95% CI, 2.50 to 5.31),
stroke (HR, 2.66; 95% CI, 1.50 to 4.74), and death (HR, 3.30; 95% CI, 2.65 to
4.12). These associations remained robust with additional adjustment for biomarkers
of inflammation, cardiac stress, and mineral metabolism; left ventricular mass;
ejection fraction; and left atrial diameter. CONCLUSIONS: Incident AF is
independently associated with two- to five-fold increased rates of developing
subsequent heart failure, myocardial infarction, stroke, or death in adults with
CKD. These findings have important implications for cardiovascular risk reduction.
AD - Division of Nephrology, Department of Medicine, University of Washington,
Seattle, Washington; nbansal@nephrology.washington.edu.
Departments of Medicine and Epidemiology and Biostatistics, University of
Pennsylvania, Philadelphia, Pennsylvania.
Department of Medicine, Johns Hopkins University, Baltimore, Maryland.
Department of Medicine, Tulane University, New Orleans, Louisiana.
Department of Medicine, University of Michigan, Ann Arbor, Michigan.
National Institutes of Health, Bethesda, Maryland.
Department of Medicine, Baylor College of Medicine, Houston, Texas.
Department of Medicine, University Hospitals, Case Western Reserve University,
Cleveland, Ohio.
Department of Medicine, University of Illinois at Chicago, Chicago, Illinois.
Department of Medicine, Wake Forest University, Winston-Salem, North Carolina.
Kaiser Permanente Northern California, Oakland, California.
Department of Epidemiology and Biostatistics, University of California, San
Francisco, San Francisco, California; and.
Department of Health Research and Policy, Stanford University, Stanford,
California.
AN - 30377231
AU - Bansal, N.
AU - Xie, D.
AU - Sha, D.
AU - Appel, L. J.
AU - Deo, R.
AU - Feldman, H. I.
AU - He, J.
AU - Jamerson, K.
AU - Kusek, J. W.
AU - Messe, S.
AU - Navaneethan, S. D.
AU - Rahman, M.
AU - Ricardo, A. C.
AU - Soliman, E. Z.
AU - Townsend, R.
AU - Go, A. S.
C2 - PMC6287862
DA - Dec
DO - 10.1681/asn.2018050514
DP - NLM
ET - 2018/11/01
IS - 12
J2 - Journal of the American Society of Nephrology : JASN
KW - Adult
Aged
Atrial Fibrillation/*complications/epidemiology/mortality
Cardiovascular Diseases/*complications/epidemiology/mortality
Cohort Studies
Female
Heart Failure/complications/epidemiology/mortality
Humans
Male
Middle Aged
Prognosis
Prospective Studies
Renal Insufficiency, Chronic/*complications/mortality
Risk Factors
Stroke/complications/epidemiology/mortality
Young Adult
*cardiovascular events
*chronic kidney disease
*heart failure
LA - eng
N1 - 1533-3450
Bansal, Nisha
Xie, Dawei
Sha, Daohang
Appel, Lawrence J
Deo, Rajat
Feldman, Harold I
He, Jiang
Jamerson, Kenneth
Kusek, John W
Messe, Steven
Navaneethan, Sankar D
Rahman, Mahboob
Ricardo, Ana Catherine
Soliman, Elsayed Z
Townsend, Raymond
Go, Alan S
U01 DK060963/DK/NIDDK NIH HHS/United States
K23 DK094829/DK/NIDDK NIH HHS/United States
R01 DK103612/DK/NIDDK NIH HHS/United States
M01 RR016500/RR/NCRR NIH HHS/United States
P20 GM109036/GM/NIGMS NIH HHS/United States
Journal Article
J Am Soc Nephrol. 2018 Dec;29(12):2859-2869. doi: 10.1681/ASN.2018050514. Epub 2018
Oct 30.
PY - 2018
SN - 1046-6673 (Print)
1046-6673
SP - 2859-2869
ST - Cardiovascular Events after New-Onset Atrial Fibrillation in Adults with CKD:
Results from the Chronic Renal Insufficiency Cohort (CRIC) Study
T2 - J Am Soc Nephrol
TI - Cardiovascular Events after New-Onset Atrial Fibrillation in Adults with CKD:
Results from the Chronic Renal Insufficiency Cohort (CRIC) Study
VL - 29
ID - 2297
ER -
TY - JOUR
AB - OBJECTIVE: To assess the estimated 10-year risk of stroke among hypertensive
outpatients known with diabetes from cardiovascular clinics of 36 tertiary
hospitals in China and to analyze the characteristics of the risk factors and the
10-year risk of stroke between the southern and the northern patients. METHODS: A
multi-center prevalence survey was conducted from October 2011 to June 2012.
Hypertensive outpatients known with diabetes were enrolled from cardiovascular
clinics of 36 tertiary hospitals in China. A total of 15 914 outpatients were
included in the final analysis. The 10-year probability of stroke was evaluated by
the Framingham stroke risk profile. According to the 10-year probability of stroke,
patients were divided into low risk ( ≤ 5%), medium risk (6%∼9%) and high risk ( ≥
10%). RESULTS: (1) Of all the hypertensive outpatients known with diabetes, the
mean age was (64.6 ± 10.1) years and the mean systolic pressure was (138.7 ± 19.3)
mmHg (1 mmHg = 0.133 kPa). Among them, 7.4% with atrial fibrillation, 11.2% with
left ventricular hypertrophy, 57.2% with cardiovascular diseases, 17.1% smokers and
37.0% using mono-hypoglycemic agent. The southern patients who were older with more
smokers had higher proportions of men and left ventricular hypertrophy, lower
levels of systolic blood pressure, and lower proportions of other cardiovascular
diseases than those of the northern patients ( all P < 0.05). (2) The mean 10-year
probability of stroke was (20.9 ± 16.2) %. The southern patients had a higher mean
10-year probability of stroke than that of the northern patients [(22.4 ± 17.1) %
vs (19.7 ± 15.2) %] (P < 0.01) . After adjusted by age and sex, the southern
patients still had a higher mean 10-year probability of stroke (P < 0.05) . (3) All
the patients had 7.7% with low risk, 17.4% with medium risk, and 74.9% with high
risk. The southern patients had lower proportions of low and medium risk than those
of the northern patients (6.7% vs 8.4%, 15.5% vs 18.9%), but had a higher
proportion of high risk than that of the northern patients (77.7% vs 72.7%, all P <
0.01). CONCLUSIONS: Among the hypertensive outpatients known with diabetes from the
cardiovascular clinics of our study, most of them were at the 10-year high risk of
stroke. The southern patients had a higher mean 10-year probability of stroke than
that of the northern patients.
AD - Department of Cardiology, Peking University First Hospital, Beijing 100034,
China. Email: huoyong @263.net.cn.
AN - 25623559
AU - Bao, B.
AU - Zhou, Y.
AU - Liu, J.
AU - Huo, Y.
DA - Dec
DP - NLM
ET - 2015/01/28
IS - 12
J2 - Zhonghua nei ke za zhi
KW - Aged
Ambulatory Care Facilities/*statistics & numerical data
Asian Continental Ancestry Group
Atrial Fibrillation
*Blood Pressure
Cardiovascular Diseases/ethnology
China/epidemiology
Diabetes Mellitus/diagnosis/drug therapy/ethnology
Female
Hospitals/*statistics & numerical data
Humans
Hypertension/complications/drug therapy/*ethnology
Hypertrophy, Left Ventricular
Hypoglycemic Agents/administration & dosage
Male
Middle Aged
Obesity/epidemiology
*Outpatients
Prevalence
Probability
Residence Characteristics
Risk Factors
Stroke/*ethnology/etiology
Tertiary Care Centers
LA - chi
N1 - Bao, Bingnan
Zhou, Yingsheng
Liu, Jun
Huo, Yong
Journal Article
Multicenter Study
China
Zhonghua Nei Ke Za Zhi. 2014 Dec;53(12):941-6.
PY - 2014
SN - 0578-1426 (Print)
0578-1426
SP - 941-6
ST - [The 10-year stroke risk in hypertensive outpatients combined with diabetes
in cardiovascular clinics of 36 tertiary hospitals in China]
T2 - Zhonghua Nei Ke Za Zhi
TI - [The 10-year stroke risk in hypertensive outpatients combined with diabetes
in cardiovascular clinics of 36 tertiary hospitals in China]
VL - 53
ID - 2788
ER -
TY - JOUR
AB - Death from acute hemispheric infarction is commonly associated with stroke
size, but the potential role of the internal carotid artery (ICA) in this
phenomenon is poorly understood. The aim of the present study was to analyse the
relation between the degree of ipsilateral and contralateral ICA stenosis, infarct
type and death. We studied 2,148 first-ever stroke patients with anterior
circulation infarction from the Lausanne Stroke Registry. Doppler ultrasonography
with frequency spectral analysis and Duplex-scanning were performed systematically
during the acute phase of stroke. The patients were divided into groups according
to the degree of ipsilateral and contralateral ICA stenosis. The case fatality
ratios (CFR) at hospital discharge were obtained for each group. Several clinical
features including age, stroke topography, level of consciousness, limb weakness on
admission, type of onset, hyperglycemia, previous transient ischemic attack,
cardiac ischemia, cardiac arrhythmia and left ventricular hypertrophy were also
studied. Mortality increased significantly with ipsilateral ICA stenosis: </=50%
stenosis, 2.8%, (44/1,549); >50% and </=90% stenosis, 3.5%, (6/170); >90% stenosis,
5.6%, (24/429); p = 0.026, but not significantly with contralateral ICA stenosis.
However, patients without ipsilateral ICA stenosis had significantly higher
mortality when contralateral stenosis was present: 16.7% (3/18) versus 2.7%
(41/1,531), p = 0.013. This corresponded to an increased frequency of strokes
involving the whole middle cerebral artery territory, with impaired consciousness
at onset of stroke. Patients with ipsilateral stenosis had similar CFR
independently of the presence or absence of contralateral stenosis. In conclusion,
patency of the contralateral ICA may be an important contributory factor of larger
infarction and indirectly of stroke mortality in patients with no ipsilateral
stenosis.
AD - Service de Neurologie, Centre Hospitalier Universitaire Vaudois, Université
de Lausanne, Suisse, Switzerland.
AN - 9885323
AU - Baptista, M. V.
AU - van Melle, G.
AU - Bogousslavsky, J.
DA - Jan
DO - 10.1159/000007992
DP - NLM
ET - 1999/01/14
IS - 1
J2 - European neurology
KW - Acute Disease
Age Distribution
Aged
Brain Ischemia/complications/diagnostic imaging/*physiopathology
Carotid Arteries/diagnostic imaging/*physiopathology
Carotid Stenosis/*complications/epidemiology/physiopathology
Cerebral Infarction/diagnostic imaging/etiology/mortality/*physiopathology
*Cerebrovascular Circulation
Comorbidity
Consciousness Disorders/etiology
Female
Hemodynamics
Humans
Hyperglycemia/epidemiology
Hypertrophy, Left Ventricular/epidemiology
Ischemic Attack, Transient/epidemiology
Male
Middle Aged
Muscle Weakness/etiology
Myocardial Ischemia/epidemiology
Risk Factors
Switzerland/epidemiology
Ultrasonography, Doppler, Transcranial
LA - eng
N1 - Baptista, M V
van Melle, G
Bogousslavsky, J
Comparative Study
Journal Article
Switzerland
Eur Neurol. 1999 Jan;41(1):15-9. doi: 10.1159/000007992.
PY - 1999
SN - 0014-3022 (Print)
0014-3022
SP - 15-9
ST - Death from ischemic stroke in the anterior circulation: the contralateral
carotid matters
T2 - Eur Neurol
TI - Death from ischemic stroke in the anterior circulation: the contralateral
carotid matters
VL - 41
ID - 2640
ER -
TY - JOUR
AB - We aimed to study in-hospital mortality after a first-ever stroke (brain
infarction or parenchymatous hemorrhage) and to determine its predictors using
easily obtainable variables. The main outcome measure was vital status at hospital
discharge. Clinical features and type of stroke, with a particular emphasis on age,
stroke topography and presumed causes of stroke, were studied in 3362 consecutive
patients from the Lausanne Stroke Registry. Overall mortality was 4.8%. Brain
hemorrhage mortality was 14.4% (48/333) and brain infarction mortality was 3.70%
(112/3029). Localizations with high mortality included infratentorial (17.5%) and
deep hemispheric (15.9%) territories for brain hemorrhage and, for brain
infarction, multiple localizations in the posterior circulation (18.4%) and large
middle cerebral artery territory (15.5%). Presumed causes of stroke associated with
high mortality included saccular aneurysm (58.3%) and hypertensive arteriopathy
(13.0%) for brain hemorrhage and, for brain infarction, dissection (10.4%),
arteritis (8.3%), hematologic conditions (6.7%) and coexisting arterial and cardiac
sources of embolism (5.2%). Multivariate logistic analysis showed that impaired
consciousness on admission and limb weakness were good predictors of mortality for
brain hemorrhage, while impaired consciousness and the cumulative effect of
progressive worsening, limb weakness, left ventricular hypertrophy, past history of
cardiac arrhythmia and previous transient ischemic attack were predictors of
mortality for brain infarction. Age was not an independent predictor of stroke
mortality, but for brain infarction the number of cumulative factors considered in
the model increased with age. Our study shows that several factors associated with
death risk are available during the first few hours after onset of stroke. Age
alone is not critical, although its interaction with other factors should be
considered.
AD - Service de Neurologie, Centre Hospitalier Universitaire Vaudois, Lausanne,
Switzerland.
AN - 10475103
AU - Baptista, M. V.
AU - van Melle, G.
AU - Bogousslavsky, J.
DA - Jul 1
DO - 10.1016/s0022-510x(99)00117-3
DP - NLM
ET - 1999/09/04
IS - 2
J2 - Journal of the neurological sciences
KW - Adolescent
Adult
Age Distribution
Aged
Brain Ischemia/etiology/*mortality
Cerebral Hemorrhage/etiology/*mortality
Female
*Hospital Mortality
Humans
Male
Middle Aged
Registries/*statistics & numerical data
Stroke/etiology/mortality
LA - eng
N1 - Baptista, M V
van Melle, G
Bogousslavsky, J
Journal Article
Netherlands
J Neurol Sci. 1999 Jul 1;166(2):107-14. doi: 10.1016/s0022-510x(99)00117-3.
PY - 1999
SN - 0022-510X (Print)
0022-510x
SP - 107-14
ST - Prediction of in-hospital mortality after first-ever stroke: the Lausanne
Stroke Registry
T2 - J Neurol Sci
TI - Prediction of in-hospital mortality after first-ever stroke: the Lausanne
Stroke Registry
VL - 166
ID - 2654
ER -
TY - JOUR
AB - INTRODUCTION: A sudden loss of consciousness followed by abnormal movements
can be ictal or syncopal in origin. Transient response by the brain to sudden
decrease of blood flow may cause sudden loss of consciousness followed by abnormal
movements that mimic seizure. Dysrhythmia is one of the important and critical
reasons of such events that should be differentiated from seizure. CASE
PRESENTATION: In this case report we describe a 55 year-old woman admitted to our
emergency department first with the impression of seizure. Eventually, it was
realized that she had suffered from brain hypo-perfusion secondary to hypokalemia
induced arrhythmia. Her arrhythmia was managed by unsynchronized biphasic shock in
acute phase and also potassium replacement. She was then admitted to the CCU
(Coronary Care Unit) where she received further care for medical management and
drug dose adjustment and was discharged 4 days later. CONCLUSIONS: Syncope from
arrhythmia most commonly results from ventricular tachycardia, which accounts for
11% of all cases of syncope. Torsades de point is a unique type of ventricular
tachycardia, characterized by QRS complexes of changing amplitude proceeded by
prolonged QT intervals and almost often followed by loss of consciousness and also
seizure like movements. Prolonged QT interval which is an important provocative
factor for torsades de point commonly results from interactions between drug
therapy, myocardial ischemia, and electrolyte disturbances such as hypokalemia or
hypomagnesaemia. Changes in the extracellular potassium level have predominant and
profound influences on the function of the cardiovascular system that may provoke
fatal demonstrations such as QT prolongation, ventricular arrhythmia and even
cardiac arrest. Electrolyte assessment is particularly important in certain patient
populations, such as the elderly in whom a variety of pathological states or
conditions like dehydration or renal failure are more common. Early identification
and correction of these disturbances are necessary to control either seizures or
seizure-like movements and prevent permanent brain damage, as anticonvulsants alone
are generally ineffective.
AD - Department of Emergency Medicine, Shohada Tajrish Hospital, Shahid Beheshti
University of Medical Sciences, Tehran, IR Iran.
Department of Pediatrics, Vali Asr Hospital, Ghazvin University of Medical
Sciences, Abyek, IR Iran.
AN - 24350174
AU - Baratloo, A.
AU - Rouhipour, A.
AU - Forouzanfar, M.
AU - Rahmati, F.
AU - Hashemi, B.
C2 - PMC3864401
DA - Dec
DO - 10.5812/traumamon.12016
DP - NLM
ET - 2013/12/19
IS - 3
J2 - Trauma monthly
KW - Arrhythmias, Cardiac
Hypokalemia
Seizures
LA - eng
N1 - 2251-7472
Baratloo, Alireza
Rouhipour, Alaleh
Forouzanfar, Mohammadmahdi
Rahmati, Farhad
Hashemi, Behrooz
Case Reports
Trauma Mon. 2013 Dec;18(3):141-4. doi: 10.5812/traumamon.12016. Epub 2013 Oct 13.
PY - 2013
SN - 2251-7464 (Print)
2251-7472
SP - 141-4
ST - Hypokalemia-induced abnormal movements: case report
T2 - Trauma Mon
TI - Hypokalemia-induced abnormal movements: case report
VL - 18
ID - 3061
ER -
TY - JOUR
AB - BACKGROUND: Stroke complicates cardiac surgical procedures in a substantial
number of patients. The mechanism of stroke is predominantly embolic, although
hypoperfusion may play a role. The aim of this study was to determine whether
radiologic appearances in this population were consistent with an embolic cause.
METHODS: We reviewed computed tomographic scans and medical records in 24 patients
who suffered stroke after cardiac operation. Stroke was evident at 24 hours in 19
patients (79%). Infarcts were multiple in 16 and single in 3 patients (group 1).
The remaining 5 patients suffered stroke beyond 24 hours and had single infarcts on
computed tomographic scan (group 2). RESULTS: In group 1, 15 patients (79%) had
bilateral cerebellar infarcts, 4 (74%) had posterior cerebral artery infarcts, 10
(53%) had posterior watershed infarcts, and 11 patients (58%) had middle cerebral
artery branch infarcts. The mean number of vascular territories involved was 5.1
(range, 1 to 10). Mobile atheromatous plaque was present in the ascending aorta or
arch in 5 of 9 patients (56%) in group 1. In group 2, stroke occurred in close
association with atrial or ventricular fibrillation in 3 of 5 patients (60%).
CONCLUSIONS: In patients with radiologic evidence of infarction, perioperative
strokes after cardiac operation are typically multiple, and involve the posterior
parts of the brain, consistent with atheroembolization. Delayed strokes may be
attributable to cardiogenic embolism.
AD - Department of Neurology, Cornell University Medical College, New York, New
York, USA.
AN - 9647076
AU - Barbut, D.
AU - Grassineau, D.
AU - Lis, E.
AU - Heier, L.
AU - Hartman, G. S.
AU - Isom, O. W.
DA - Jun
DO - 10.1016/s0003-4975(98)00272-0
DP - NLM
ET - 1998/07/01
IS - 6
KW - Aged
Aged, 80 and over
Aorta/diagnostic imaging
Aorta, Thoracic/diagnostic imaging
Aortic Diseases/diagnostic imaging/etiology
Arteriosclerosis/diagnostic imaging/etiology
Cerebellum/blood supply
Cerebral Arteries/diagnostic imaging
Cerebral Infarction/diagnostic imaging/*etiology
Cerebrovascular Disorders/diagnostic imaging/*etiology
Echocardiography, Transesophageal
Embolism/diagnostic imaging/etiology
Female
Humans
Infarction/diagnostic imaging/etiology
Intracranial Embolism and Thrombosis/diagnostic imaging/etiology
Intraoperative Complications/diagnostic imaging
Male
Middle Aged
Time Factors
Ventricular Fibrillation/etiology
LA - eng
N1 - Barbut, D
Grassineau, D
Lis, E
Heier, L
Hartman, G S
Isom, O W
Journal Article
Netherlands
Ann Thorac Surg. 1998 Jun;65(6):1656-9. doi: 10.1016/s0003-4975(98)00272-0.
PY - 1998
SN - 0003-4975 (Print)
0003-4975
SP - 1656-9
ST - Posterior distribution of infarcts in strokes related to cardiac operations
TI - Posterior distribution of infarcts in strokes related to cardiac operations
VL - 65
ID - 2634
ER -
TY - JOUR
AB - BACKGROUND: Maintenance of sinus rhythm has been associated with lower
mortality, but whether atrial fibrillation (AF) ablation per se benefits hard
outcomes such as mortality and stroke is still debated. OBJECTIVE: To determine
whether AF ablation is associated with a reduction in all-cause mortality and
stroke compared with medical therapy alone. METHODS: Literature search looking for
both randomized and observational studies comparing AF catheter ablation vs.
medical management. Data pooled using random-effects. Risk ratios (RR) with 95%
confidence intervals (CI) used as a measure of treatment effect. The primary and
secondary outcomes were all-cause mortality and occurrence of cerebrovascular
events during follow-up, respectively. RESULTS: Thirty studies were eligible for
inclusion, comprising 78,966 patients (25,129 receiving AF ablation and 53,837 on
medical treatment) and 233,990patient-years of follow-up. The pooled data of
studies revealed that ablation was associated with lower risk of all-cause
mortality: 5.7% vs. 17.9%; RR=0.44, 95% CI 0.32-0.62, p<0.001. In a sensitivity
analysis by study design, a survival benefit of AF ablation was seen in randomized
studies, with no heterogeneity (mortality risk 4.2% vs. 8.9%; RR=0.55, 95% CI 0.39-
0.79, p=0.001, I(2)=0%), and also in observational studies, but with marked
heterogeneity (6.1% vs. 18.3%; RR=0.39, 95% CI 0.26-0.59, p<0.001, I(2)=95%). The
mortality benefit in randomized studies was mainly driven by trials performed in
patients with left ventricular (LV) dysfunction and heart failure. The pooled risk
of a cerebrovascular event was lower in patients receiving AF ablation (2.3% vs.
5.5%; RR=0.57, 95% CI 0.46-0.70, p<0.001, I(2)=62%), but no difference was seen in
randomized trials (2.2% vs. 2.1%; RR=0.94, 95% CI 0.46-1.94, p=0.87, I(2)=0%).
CONCLUSIONS: Ablation of atrial fibrillation associates with a survival benefit
compared with medical treatment alone, although evidence is restricted to the
setting of heart failure and LV systolic dysfunction.
AD - Cardiology Department, Papworth Hospital NHS Foundation Trust, Cambridge, UK.
Electronic address: sergioncbarra@gmail.com.
Cardiology Department, Papworth Hospital NHS Foundation Trust, Cambridge, UK;
Division of Clinical Electrophysiology, Department of Cardiology, Grochowski
Hospital, Postgraduate Medical School, Warsaw, Poland.
Paris Cardiovascular Research Center, Paris, France; Cardiology Department, MaxCure
Hospitals, Hyderabad, India.
Cardiology Department, Clinique Pasteur, Toulouse, France.
Cardiology Department, Papworth Hospital NHS Foundation Trust, Cambridge, UK.
Cardiology Department, V. N. Gaia Hospital Center, V. N. Gaia, Portugal.
Paris Cardiovascular Research Center, Paris, France; Cardiology Department,
European Georges Pompidou Hospital, Paris, France; Paris Descartes University,
Paris, France.
Barts Heart Centre, Barts Health NHS Trust, London, UK.
AN - 29887429
AU - Barra, S.
AU - Baran, J.
AU - Narayanan, K.
AU - Boveda, S.
AU - Fynn, S.
AU - Heck, P.
AU - Grace, A.
AU - Agarwal, S.
AU - Primo, J.
AU - Marijon, E.
AU - Providência, R.
DA - Sep 1
DO - 10.1016/j.ijcard.2018.03.068
DP - NLM
ET - 2018/06/12
KW - Atrial Fibrillation/*mortality/*surgery
Catheter Ablation/adverse effects/*mortality/trends
Humans
Mortality/trends
Observational Studies as Topic/methods
Randomized Controlled Trials as Topic/methods
Stroke/*mortality/*surgery
Treatment Outcome
Ablation
Atrial fibrillation
Meta-analysis
Mortality
Stroke
LA - eng
N1 - 1874-1754
Barra, Sérgio
Baran, Jakub
Narayanan, Kumar
Boveda, Serge
Fynn, Simon
Heck, Patrick
Grace, Andrew
Agarwal, Sharad
Primo, João
Marijon, Eloi
Providência, Rui
Journal Article
Meta-Analysis
Systematic Review
Netherlands
Int J Cardiol. 2018 Sep 1;266:136-142. doi: 10.1016/j.ijcard.2018.03.068.
PY - 2018
SN - 0167-5273
SP - 136-142
ST - Association of catheter ablation for atrial fibrillation with mortality and
stroke: A systematic review and meta-analysis
T2 - Int J Cardiol
TI - Association of catheter ablation for atrial fibrillation with mortality and
stroke: A systematic review and meta-analysis
VL - 266
ID - 2323
ER -
TY - JOUR
AB - Atrial fibrillation (AF) is the most common sustained arrhythmia. While
antiarrhythmic agents and electrical cardioversion are highly effective in
restoring sinus rhythm, the results obtained in prevention of recurrences are
disappointing. Recently, angiotensin II has been recognized as a key factor in
atrial structural and electrical remodeling associated with AF. So there are
several potential mechanisms by which inhibition of the renin-angiotensin-
aldosterone system may reduce AF. In this review, we report the results of studies
evaluating the effect of angiotensin II receptor blockers (ARBs) in various
clinical settings (i.e., lone AF, hypertension, high-risk patients, congestive
heart failure, secondary prevention). However, many of these studies are small and
retrospective and have a limited follow-up; moreover, since AF is related to
several causes, chiefly heart diseases, patients with different characteristics
have often been enrolled. Thus, it is not surprising that the results obtained are
frequently conflicting. With these limitations and considering only the results of
larger studies with longer follow-up, ARBs are effective in preventing AF in
patients with congestive heart failure or hypertension with left ventricular
hypertrophy or coronary artery/cerebrovascular disease. In any case, the use of
ARBs is not recommended at present in clinical practice to prevent AF.
AD - Antonio Cardarelli Hospital, Cardiology Unit, Via Antonio Cardarelli 9, 80128
Naples, Italy.
AN - 19466911
AU - Barra, S.
AU - Silvestri, N.
AU - Vitagliano, G.
AU - Madrid, A.
AU - Gaeta, G.
DA - Jun
DO - 10.1517/14656560902973736
DP - NLM
ET - 2009/05/27
IS - 9
J2 - Expert opinion on pharmacotherapy
KW - Angiotensin II Type 1 Receptor Blockers/pharmacology/*therapeutic use
Animals
Atrial Fibrillation/physiopathology/*prevention & control
Clinical Trials as Topic/methods
Contraindications
Humans
Receptor, Angiotensin, Type 1/physiology
LA - eng
N1 - 1744-7666
Barra, Silvia
Silvestri, Nunzia
Vitagliano, Giancarlo
Madrid, Alfredo
Gaeta, Giovanni
Journal Article
Review
England
Expert Opin Pharmacother. 2009 Jun;10(9):1395-411. doi: 10.1517/14656560902973736.
PY - 2009
SN - 1465-6566
SP - 1395-411
ST - Angiotensin II receptor blockers in the prevention of atrial fibrillation
T2 - Expert Opin Pharmacother
TI - Angiotensin II receptor blockers in the prevention of atrial fibrillation
VL - 10
ID - 2881
ER -
TY - JOUR
AB - The objective of the investigation was an attempt to analyze some aspects of
the heart-brain relationship. The group was formed by 626 patients with the
diagnosis of focal cerebral ischaemia (CI) and 191 patients with the diagnosis of
subarachnoidal haemorrhage (SAH). It was revealed that the CI group comprised 77.3%
patients with a pathological finding on the heart. Analysis revealed moreover that
in the group of patients with "congestive heart failure" there was a significantly
higher percentage of patients with a severe neurological deficit as compared to the
group with a "normal" ECG (p < 0.001). Atrial fibrillation causes a fivefold
increase of the risk of cerebral infarction. The incidence of ECG abnormalities of
various types was significantly higher in the group of patients with CI during
long-term ECG monitoring, as compared to the results of conventional ECG
examination (p < 0.001). The value of long-term ECG monitoring was confirmed also
in an investigation of these changes in a group of patients with arterial
hypertension, quari potential candidates of cerebral infarction. The relationship
between cardiac and cerebral function was tested also in an investigation focused
on the incidence of ectopic activity and changes of the QT interval. It was
revealed that while the percentage rate of ectopic activity assessed by
conventional ECG examination was in the group of "improved" patients 18.0%, long-
term monitoring revealed a rate as high as 48.0%, the difference being
statistically significant. Similar significant differences were observed also on
analysis of the QT interval: in the group of patients with neurological
"improvement" the QT interval was significantly shorter, as compared with the group
with neurological "deterioration". It was assumed that the prolonged QT interval
could be the cause of sudden death. A cardio-cerebral relationship was found also
on analysis of changes of the cerebral circulation (CBF) in different forms of
cardiac insufficiency. It was revealed that isolated ventricular extrasystoles
reduced the CBF by 8.0%, isolated atrial extrasystoles by 12% and in atrio-
ventricular tachyarrhythmia the CBF is reduced by as much as 25.0%. The cerebro-
cardiac relationship was tested in a group of patients with SAH. ECG abnormalities
of a varying type were found in 30.7% of the patients with SAH. They are described
in as many as 100% of patients and were detected also other in cerebral disorders,
such as contusion of the brain, intraoerebral haemorrhage and cerebral tumours.
AD - I. neurologická klinika FN a LF UK, Bratislava.
AN - 8928426
AU - Bartko, D.
AU - Dukát, A.
AU - Janco, S.
AU - Porubec, V.
AU - Traubner, P.
DA - Jul
DP - NLM
ET - 1996/07/01
IS - 7
J2 - Vnitrni lekarstvi
KW - Arrhythmias, Cardiac/*complications/physiopathology
Cerebrovascular Disorders/*etiology/physiopathology
Electrocardiography
Heart Failure/*complications/physiopathology
Humans
Ischemic Attack, Transient/etiology/physiopathology
Middle Aged
Subarachnoid Hemorrhage/*etiology/physiopathology
LA - slo
N1 - Bartko, D
Dukát, A
Janco, S
Porubec, V
Traubner, P
English Abstract
Journal Article
Czech Republic
Vnitr Lek. 1996 Jul;42(7):482-9.
OP - Srdce a mozog. Niektoré aspekty vzájomných vzt'ahov.
PY - 1996
SN - 0042-773X (Print)
0042-773x
SP - 482-9
ST - [The heart and the brain. Aspects of their interrelations]
T2 - Vnitr Lek
TI - [The heart and the brain. Aspects of their interrelations]
VL - 42
ID - 2702
ER -
TY - JOUR
AB - Atrial fibrillation (AF), one of the most prevalent supra-ventricular
arrhythmia in adults, is related to a substantial increase in the risk of
thromboembolic events requiring tailored preventive strategy. In AF, antithrombotic
therapy should be individualized according to a careful decisionmaking process,
taking in account the likely concomitant presence of risk factors for stroke and
bleeding. Anticoagulation management is particularly challenging in women with AF,
to the extent that female sex is incorporated in commonly used stratification
schemes for both thromboembolic and bleeding risk evaluation. Nevertheless, gender-
based differences on the efficacy and safety of either "old" (i.e. vitamin K
antagonist) or "new" oral anticoagulants (i.e. direct thrombin inhibitors and
activated factor X inhibitors) are not conclusive and not always reported. This
review aims to analyse the literature on sex differences in AF anticoagulation
management. We focus on safety data, bleeding complications and specific
haemostatic mechanisms currently under investigation, which could account for
observed disparities among sexes. Moreover, details on sex difference in response
to anticoagulant treatment will be discussed. Comparing old and new
antithrombotics, a need clearly emerges for differentiated and integrated
strategies for the treatment of AF in female patients.
AD - I Clinica Medica, Viale del Policlinico 155, Roma, 00161, Italy.
stefania.basili@uniroma1.it.
AN - 25686858
AU - Basili, S.
AU - Raparelli, V.
AU - Proietti, M.
AU - Napoleone, L.
AU - Ferroni, P.
AU - Franconi, F.
DO - 10.2174/1570161113666150216152054
DP - NLM
ET - 2015/02/18
IS - 6
J2 - Current vascular pharmacology
KW - Administration, Oral
Adult
Anticoagulants/*administration & dosage/adverse effects/pharmacology
Atrial Fibrillation/complications/*drug therapy
Female
Humans
Male
Risk Factors
Sex Factors
LA - eng
N1 - 1875-6212
Basili, Stefania
Raparelli, Valeria
Proietti, Marco
Napoleone, Laura
Ferroni, Patrizia
Franconi, Flavia
Journal Article
Review
United Arab Emirates
Curr Vasc Pharmacol. 2015;13(6):738-48. doi: 10.2174/1570161113666150216152054.
PY - 2015
SN - 1570-1611
SP - 738-48
ST - Old And New Oral Anticoagulants In Management Of Atrial Fibrillation: A
Double-Edged Sword For Women
T2 - Curr Vasc Pharmacol
TI - Old And New Oral Anticoagulants In Management Of Atrial Fibrillation: A
Double-Edged Sword For Women
VL - 13
ID - 2398
ER -
TY - JOUR
AB - Atrial fibrillation (AF) is the most common sustained arrhythmia and is
associated with stroke, cognitive impairment, and cardiovascular death. Some
predisposing factors - as aging, diabetes, hypertension - induce and maintain
electrophysiological and ultrastructural remodeling that usually includes fibrosis.
Interatrial conduction disturbances play a crucial role in the initiation of atrial
fibrosis and in its associated complications. The diagnosis of interatrial blocks
(IABs) is easy to perform using the surface ECG. IAB is classified as partial when
the P wave duration is ≥120 ms, and advanced if the P wave also presents a biphasic
pattern in II, III and aVF. IAB is very frequent in the elderly and, particularly
in the case of the advanced type, is associated with AF, AF recurrences, stroke,
and dementia. The anticoagulation in elderly patients at high risk of AF without
documented arrhythmias is an open issue but recent data suggest that it might have
a role, particularly in elderly patients with structural heart disease, high
CHA(2)DS(2)VASc (Congestive heart failure/left ventricular dysfunction,
Hypertension, Age ≥ 75 [doubled], Diabetes, Stroke [doubled] - Vascular disease,
Age 65-74, and Sex category [female]), and advanced IAB. In this debate, we discuss
the association of surface ECG IAB, a marker of atrial fibrosis, with AF and
stroke. We also present the rationale that justifies further studies regarding
anticoagulation in some of these patients.
AD - Fundació Investigació Cardiovascular, ICCC, Hospital de Sant Pau, Barcelona,
Spain.
Hospital General Universitario Gregorio Marañón. CIBERCV, Universidad Complutense,
Universidad Europea, Madrid, Spain. mmselles@secardiologia.es.
Servicio de Cardiología, Hospital General Universitario Gregorio Marañón, Calle Dr.
Esquerdo 46, 28007, Madrid, Spain. mmselles@secardiologia.es.
Hospital Universitari Germans Trias i Pujol, UAB, Barcelona, Spain.
Hospital del Mar Medical Research Institute, Barcelona, Spain.
Queen's University, Kingston, ON, Canada.
AN - 28760133
AU - Bayés de Luna, A.
AU - Martínez-Sellés, M.
AU - Bayés-Genís, A.
AU - Elosua, R.
AU - Baranchuk, A.
C2 - PMC5537952
DA - Jul 31
DO - 10.1186/s12872-017-0650-y
DP - NLM
ET - 2017/08/02
IS - 1
J2 - BMC cardiovascular disorders
KW - Aged
Anticoagulants/*administration & dosage/adverse effects
Atrial Fibrillation/complications/diagnosis/*drug therapy/physiopathology
Clinical Decision-Making
Drug Administration Schedule
Female
Fibrosis
Heart Atria/*drug effects/pathology/physiopathology
Humans
Interatrial Block/complications/*diagnostic imaging/physiopathology
Male
Recurrence
Risk Assessment
Risk Factors
Stroke/etiology/physiopathology/*prevention & control
Treatment Outcome
*Atrial fibrillation
*Interatrial block
*Risk
*Stroke
Not applicable. COMPETING INTERESTS: The authors declare that they have no
competing
interests. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to
jurisdictional claims in published maps and institutional affiliations.
LA - eng
N1 - 1471-2261
Bayés de Luna, Antoni
Martínez-Sellés, Manuel
Orcid: 0000-0003-0289-6229
Bayés-Genís, Antoni
Elosua, Roberto
Baranchuk, Adrian
Journal Article
BMC Cardiovasc Disord. 2017 Jul 31;17(1):211. doi: 10.1186/s12872-017-0650-y.
PY - 2017
SN - 1471-2261
SP - 211
ST - Surface ECG interatrial block-guided treatment for stroke prevention:
rationale for an attractive hypothesis
T2 - BMC Cardiovasc Disord
TI - Surface ECG interatrial block-guided treatment for stroke prevention:
rationale for an attractive hypothesis
VL - 17
ID - 2392
ER -
TY - JOUR
AB - BACKGROUND: When temporary arterial occlusion of the parent artery is
difficult for anatomical reasons, or when inadvertent aneurysmal rupture occurs
during surgical dissection, adenosine administration can be used to produce flow
arrest and brief, profound systemic hypotension that can facilitate intracranial
aneurysm clip ligation. There is a concern, however, that the flow arrest and
profound hypotension produced by adenosine, although brief, may cause cerebral
ischemia and therefore worsen neurologic outcome compared with other techniques to
facilitate aneurysm clip ligation. Therefore, we performed a retrospective, case-
control study to determine whether adenosine-induced flow arrest had negative
effects on the neurologic outcome of our patients. METHODS: We reviewed the
perioperative records of all patients in our intracranial aneurysm surgery outcomes
database between August 1, 2006, and June 15, 2012. The primary outcome was the
presence or absence of a poor neurologic outcome 48 hours after surgery, with a
modified Rankin scale score >2 being defined as a poor neurologic outcome. The
neurologic outcome at the time of hospital discharge was a secondary outcome.
Secondary outcomes related to cardiac morbidity included atrial or ventricular
arrhythmia requiring treatment and elevated cardiac biomarkers consistent with
ischemia (i.e., Troponin-I). RESULTS: During the study period, adenosine-induced
flow arrest was used in 72 of the 413 patients (17.4%) who underwent intracranial
aneurysm clip ligation. The difference in the incidence of poor neurological
outcome, with or without the use of adenosine, was no larger than 15.7% at 48 hours
after surgery (P =0.524) or -12.7% at discharge (P = 0.741). In addition, the
difference in the incidence of cardiac morbidity was no larger than -16.0% for
persistent arrhythmia (P = 0.155) or -9.4% for biomarkers of myocardial ischemia (P
= 0.898) in the initial 48 hours after surgery. CONCLUSION: When used to facilitate
intracranial aneurysm clip ligation, adenosine-induced flow arrest was associated
with no more than a 15.7% increase or a 12.7% decrease in the incidence of a poor
neurologic outcome at either 48 hours or at the time of hospital discharge. In
addition, adenosine use was not associated with cardiac morbidity in the
perioperative period (i.e., persistent arrhythmia or biomarkers of cardiac
ischemia).
AD - From the Department of Anesthesiology and Neurological Surgery, Northwestern
University Feinberg School of Medicine, Chicago, Illinois.
AN - 24108260
AU - Bebawy, J. F.
AU - Zeeni, C.
AU - Sharma, S.
AU - Kim, E. S.
AU - DeWood, M. S.
AU - Hemmer, L. B.
AU - Ramaiah, V. K.
AU - Bendok, B. R.
AU - Koht, A.
AU - Gupta, D. K.
DA - Nov
DO - 10.1213/ANE.0b013e3182a6d31b
DP - NLM
ET - 2013/10/11
IS - 5
J2 - Anesthesia and analgesia
KW - Adenosine/*adverse effects
Adult
Aged
Cerebrovascular Circulation/drug effects
Female
Humans
Intracranial Aneurysm/*surgery
Ligation/adverse effects
Male
Middle Aged
Myocardial Ischemia/etiology
Nervous System Diseases/diagnosis/*etiology
Neurosurgical Procedures/*adverse effects/methods
Perfusion
Perioperative Care
Surgical Instruments/*adverse effects
Treatment Outcome
LA - eng
N1 - 1526-7598
Bebawy, John F
Zeeni, Carine
Sharma, Sonal
Kim, Edina S
DeWood, Mark S
Hemmer, Laura B
Ramaiah, Vijay K
Bendok, Bernard R
Koht, Antoun
Gupta, Dhanesh K
Journal Article
United States
Anesth Analg. 2013 Nov;117(5):1205-10. doi: 10.1213/ANE.0b013e3182a6d31b.
PY - 2013
SN - 0003-2999
SP - 1205-10
ST - Adenosine-induced flow arrest to facilitate intracranial aneurysm clip
ligation does not worsen neurologic outcome
T2 - Anesth Analg
TI - Adenosine-induced flow arrest to facilitate intracranial aneurysm clip
ligation does not worsen neurologic outcome
VL - 117
ID - 2899
ER -
TY - JOUR
AB - In order to study the influence of repetitive episodes of ventricular
fibrillation (VF) during defibrillator implantation on the electrical activity of
the brain, we performed an electroencephalographic (EEG) monitoring during
implantation procedure in 18 patients. For defibrillation threshold testing 62
episodes of VF (1-6 episodes per patient) were induced. The mean duration of VF was
20 +/- 12 s; the mean duration of hypotension during an episode (defined as a mean
arterial pressure of 50 mm Hg or less) was 33 +/- 16 s. EEG monitoring was
performed using the International 10-20 System. The duration of cardiac arrest-
related EEG alteration was assessed by an experienced neurologist and could be
determined in 41 test-episodes; in 21 episodes analysis was not possible due to
poor recordings. Ischemia-related EEG changes started 7.8 +/- 4.6 s after VF
induction and lasted 64 +/- 49 s (range, 12-240). The duration of EEG alteration
was significantly (p < .001) correlated with the duration of VF episodes (r = .71)
and the associated hypotension (r = .82). With regard to patients the duration of
ischemia related EEG changes also correlated significantly (p = .001) with the
individual cumulative duration of VF (r = .85) and the associated hypotension (r
= .88). In females EEG changes lasted longer than in males (p = .03); this finding,
however, was only based on 2 women. Other clinical parameters, such as patient age,
degree of congestive heart failure, left ventricular ejection fraction, stroke
volume and cardiac index, the order of episodes within the testing sequence, and
the time interval between episodes did not correlate with the duration of EEG
alteration after VF induction. The duration of ischemia-related EEG alteration
during VF episodes depends on the duration of cardiac arrest. In females EEG
changes tended to last longer than in males, however, this finding has to be
confirmed. An association with other clinical parameters has not been observed.
Limitation of VF duration appears to be the most important factor to avoid
prolonged cerebral ischemia.
AD - Abteilung Kardiologie/Pulmologie Klinikum Benjamin Franklin Freie Universität
Berlin.
AN - 7502566
AU - Behrens, S.
AU - Spies, C.
AU - Neumann, U.
AU - Ehlers, C.
AU - Kraemer, S.
AU - Brüggemann, T.
AU - Andresen, D.
DA - Oct
DP - NLM
ET - 1995/10/01
IS - 10
J2 - Zeitschrift fur Kardiologie
KW - Adult
Aged
Brain Ischemia/*etiology/physiopathology
Cerebral Cortex/blood supply/physiopathology
*Defibrillators, Implantable
Delta Rhythm
Electroencephalography
Female
Hemodynamics/physiology
Humans
Male
Middle Aged
Theta Rhythm
Ventricular Fibrillation/physiopathology/*therapy
LA - ger
N1 - Behrens, S
Spies, C
Neumann, U
Ehlers, C
Kraemer, S
Brüggemann, T
Andresen, D
English Abstract
Journal Article
Germany
Z Kardiol. 1995 Oct;84(10):798-807.
OP - Zerebrale Ischämie während der Implantation automatischer Defibrillatoren.
PY - 1995
SN - 0300-5860 (Print)
0300-5860
SP - 798-807
ST - [Cerebral ischemia during implantation of automatic defibrillators]
T2 - Z Kardiol
TI - [Cerebral ischemia during implantation of automatic defibrillators]
VL - 84
ID - 2916
ER -
TY - JOUR
AB - BACKGROUND: Atrial fibrillation (AF) causes substantial morbidity. It is
uncertain whether AF is associated with excess mortality independent of associated
cardiac conditions and risk factors. METHODS AND RESULTS: We examined the mortality
of subjects 55 to 94 years of age who developed AF during 40 years of follow-up of
the original Framingham Heart Study cohort. Of the original 5209 subjects, 296 men
and 325 women (mean ages, 74 and 76 years, respectively) developed AF and met
eligibility criteria. By pooled logistic regression, after adjustment for age,
hypertension, smoking, diabetes, left ventricular hypertrophy, myocardial
infarction, congestive heart failure, valvular heart disease, and stroke or
transient ischemic attack, AF was associated with an OR for death of 1.5 (95% CI,
1.2 to 1.8) in men and 1.9 (95% CI, 1.5 to 2.2) in women. The risk of mortality
conferred by AF did not significantly vary by age. However, there was a significant
AF-sex interaction: AF diminished the female advantage in survival. In secondary
multivariate analyses, in subjects free of valvular heart disease and preexisting
cardiovascular disease, AF remained significantly associated with excess mortality,
with about a doubling of mortality in both sexes. CONCLUSIONS: In subjects from the
original cohort of the Framingham Heart Study, AF was associated with a 1.5- to
1.9-fold mortality risk after adjustment for the preexisting cardiovascular
conditions with which AF was related. The decreased survival seen with AF was
present in men and women and across a wide range of ages.
AD - National Heart, Lung, and Blood Institute's Framingham Heart Study, National
Institutes of Health, Mass, USA. emelia@fram.nhlbi.nih.gov
AN - 9737513
AU - Benjamin, E. J.
AU - Wolf, P. A.
AU - D'Agostino, R. B.
AU - Silbershatz, H.
AU - Kannel, W. B.
AU - Levy, D.
DA - Sep 8
DO - 10.1161/01.cir.98.10.946
DP - NLM
ET - 1998/09/16
IS - 10
J2 - Circulation
KW - Adult
Age Factors
Aged
Aged, 80 and over
Atrial Fibrillation/*mortality
Blood Pressure
Cohort Studies
Diabetes Mellitus/epidemiology
Female
Follow-Up Studies
Heart Valve Diseases/epidemiology
Humans
Male
Massachusetts
Middle Aged
Regression Analysis
Risk Factors
Sex Factors
Smoking/epidemiology
Time Factors
LA - eng
N1 - Benjamin, E J
Wolf, P A
D'Agostino, R B
Silbershatz, H
Kannel, W B
Levy, D
5-R01-NS-17590-16/NS/NINDS NIH HHS/United States
Journal Article
United States
Circulation. 1998 Sep 8;98(10):946-52. doi: 10.1161/01.cir.98.10.946.
PY - 1998
SN - 0009-7322 (Print)
0009-7322
SP - 946-52
ST - Impact of atrial fibrillation on the risk of death: the Framingham Heart
Study
T2 - Circulation
TI - Impact of atrial fibrillation on the risk of death: the Framingham Heart
Study
VL - 98
ID - 2290
ER -
TY - JOUR
AB - Patients with newly diagnosed atrial fibrillation (AF) and a rapid
ventricular response may present with a reduced left ventricular ejection fraction
(LVEF). We compared long-term outcomes of these patients with those with preserved
LVEF. This retrospective cohort study included 385 consecutive adults with newly
diagnosed AF with rapid ventricular response, presenting to a single medical center
from January 2006 to August 2014. Patients with a history of coronary artery
disease or known cardiomyopathy were excluded. Patients were divided into 2 groups:
those with an LVEF ≤55% (n = 147) (REF) and those with an LVEF >55% (n = 238)
(PEF). Echocardiographic parameters, all-cause mortality, cardiovascular mortality,
and stroke rates were compared between both groups at baseline and a minimum of 1-
year follow-up. The mean age of patients was 68 ± 1.1 in REF versus 60 ± 7.4 in PEF
(p = 0.39). There were no significant differences in baseline co-morbidities
between both groups. The mean LVEF during the index admission was 47.7 ± 0.8% in
REF versus 65.5 ± 0.3% in PEF. The average duration of follow-up was 2.8 years.
Patients with REF had higher all-cause mortality (32.7% REF vs 20.6% PEF, odds
ratio 2.17, p = 0.008). Patients with REF had higher rates of subsequent clinic or
ER visits for AF with a rapid ventricular response (32% REF vs 22.7% PEF, p =
0.044). The incidence of stroke was similar between both groups (17% REF vs 18.9%
PEF, p = 0.639). Of the patients with REF, 64% had subsequent EF recovery and had
similar outcomes compared with patients with PEF. Baseline LV end-diastolic
diameter predicted all-cause mortality (odds ratio 1.14, p = 0.003) in the REF
group. None of the echocardiographic parameters predicted EF recovery. In
conclusion, in patients with new AF with rapid ventricular response, REF was
associated with higher long-term all-cause mortality. Those with subsequent LVEF
recovery after medical therapy appear to have a similar prognosis compared with
those with initial PEF.
AD - Division of Cardiovascular Medicine, Department of Internal Medicine,
University of Wisconsin Hospitals and Clinics, Madison, Wisconsin. Electronic
address: minamecheal@yahoo.com.
Department of Medicine, University of Wisconsin Hospitals and Clinics, Madison,
Wisconsin.
Department of Biostatistics, University of Wisconsin School of Medicine and Public
Health, Madison, Wisconsin.
Division of Cardiovascular Medicine, Department of Internal Medicine, University of
Wisconsin Hospitals and Clinics, Madison, Wisconsin.
AN - 28029361
AU - Benjamin, M. M.
AU - Chaddha, A.
AU - Sampene, E.
AU - Field, M. E.
AU - Rahko, P. S.
DA - Dec 15
DO - 10.1016/j.amjcard.2016.08.073
DP - NLM
ET - 2016/12/29
IS - 12
KW - Aged
Atrial Fibrillation/complications/diagnostic imaging/*physiopathology
Cardiovascular Diseases/mortality
Cohort Studies
Echocardiography
Female
Humans
Male
Middle Aged
Mortality
Odds Ratio
Prognosis
*Stroke Volume
LA - eng
N1 - 1879-1913
Benjamin, Mina M
Chaddha, Ashish
Sampene, Emmanuel
Field, Michael E
Rahko, Peter S
Comparative Study
Journal Article
United States
Am J Cardiol. 2016 Dec 15;118(12):1831-1835. doi: 10.1016/j.amjcard.2016.08.073.
Epub 2016 Oct 11.
PY - 2016
SN - 0002-9149
SP - 1831-1835
ST - Comparison of Outcomes of Atrial Fibrillation in Patients With Reduced Versus
Preserved Left Ventricular Ejection Fraction
T2 - Am J Cardiol
TI - Comparison of Outcomes of Atrial Fibrillation in Patients With Reduced Versus
Preserved Left Ventricular Ejection Fraction
VL - 118
ID - 2519
ER -
TY - JOUR
AB - Following acute myocardial infarction, re-establishment of coronary perfusion
aggravates further injuries in the heart and remote organs including the brain as a
consequence of ischemia/reperfusion (I/R) injury. Since pretreatment with metformin
attenuated both cardiac and cerebral I/R injury via AMP-activated protein kinase
(AMPK) pathways, we hypothesized that metformin given after ischemia mitigates both
cardiac and brain pathologies following cardiac I/R. Male Wistar rats were
subjected to either cardiac I/R (30 min-ischemia/120 min-reperfusion; n = 30) or
sham operation (n = 5). Metformin 200 mg/kg was given intravenously to the cardiac
I/R group (n = 10/group), either during ischemia (D-MET) or at the onset of
reperfusion (R-MET). Left ventricular ejection fraction (LVEF) and arrhythmia
scores were determined. The heart and brain tissues were collected to determine the
extent of injury, mitochondrial function, and apoptosis. Additionally, microglial
morphology, Alzheimer's proteins, and dendritic spine density were determined in
the brain. Cardiac I/R led to not only reduced LVEF, cardiac mitochondrial
dysfunction, and arrhythmias, but also brain mitochondrial dysfunction, apoptosis,
Alzheimer's protein aggregation, microglial activation, and dendritic spine loss. A
single dose of metformin did not alter p-AMPK/AMPK in both organs. In the heart,
impaired LVEF, arrhythmias, infarct size expansion, mitochondrial dysfunction, and
apoptosis were not alleviated. On the contrary, metformin attenuated brain
mitochondrial dysfunction, apoptosis, and Alzheimer's protein levels. Microglial
morphology and dendritic spine density were additionally preserved in D-MET group.
In conclusion, metformin given during ischemia preferentially provides
neuroprotection against brain mitochondrial dysfunction, apoptosis, microglial
activation, and dendritic spine loss in an AMPK-independent manner following
cardiac I/R injury.
AD - Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center,
Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand; Center of
Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai
50200, Thailand.
Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center,
50200, Thailand; Cardiac Electrophysiology Unit, Department of Physiology, Faculty
of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center,
50200, Thailand; Department of Oral Biology and Diagnostic Sciences, Faculty of
Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand. Electronic address:
siriporn.c@cmu.ac.th.
AN - 32621957
AU - Benjanuwattra, J.
AU - Apaijai, N.
AU - Chunchai, T.
AU - Kerdphoo, S.
AU - Jaiwongkam, T.
AU - Arunsak, B.
AU - Wongsuchai, S.
AU - Chattipakorn, N.
AU - Chattipakorn, S. C.
DA - Jul 2
DO - 10.1016/j.bbadis.2020.165893
DP - NLM
ET - 2020/07/06
IS - 10
J2 - Biochimica et biophysica acta. Molecular basis of disease
KW - Ampk
Apoptosis
Brain
Cardiac ischemia/reperfusion
Heart
Metformin
Mitochondria
competing financial interests or personal relationships that could have appeared to
influence the work reported in this paper.
LA - eng
N1 - 1879-260x
Benjanuwattra, Juthipong
Apaijai, Nattayaporn
Chunchai, Titikorn
Kerdphoo, Sasiwan
Jaiwongkam, Thidarat
Arunsak, Bussarin
Wongsuchai, Supawit
Chattipakorn, Nipon
Chattipakorn, Siriporn C
Journal Article
Netherlands
Biochim Biophys Acta Mol Basis Dis. 2020 Jul 2;1866(10):165893. doi:
10.1016/j.bbadis.2020.165893.
PY - 2020
SN - 0925-4439
SP - 165893
ST - Metformin preferentially provides neuroprotection following cardiac
ischemia/reperfusion in non-diabetic rats
T2 - Biochim Biophys Acta Mol Basis Dis
TI - Metformin preferentially provides neuroprotection following cardiac
ischemia/reperfusion in non-diabetic rats
VL - 1866
ID - 3072
ER -
TY - JOUR
AB - Background and Purpose- Atrial fibrillation (AF) is associated with dementia
independent of clinical stroke. The mechanisms underlying this association remain
unclear. In a community-based cohort, the ARIC study (Atherosclerosis Risk in
Communities), we evaluated (1) the longitudinal association of incident AF and (2)
the cross-sectional association of prevalent AF with brain magnetic resonance
imaging (MRI) abnormalities. Methods- The longitudinal analysis included 963
participants (mean age, 73±4.4 years; 62% women; 51% black) without prevalent
stroke or AF who underwent a brain MRI in 1993 to 1995 and a second MRI in 2004 to
2006 (mean, 10.6±0.8 years). Outcomes included subclinical cerebral infarctions,
sulcal size, ventricular size, and, for the cross-sectional analysis, white matter
hyperintensity volume and total brain volume. Results- In the longitudinal
analysis, 29 (3.0%) participants developed AF after the first brain MRI. Those who
developed AF had higher odds of increase in subclinical cerebral infarctions (odds
ratio [OR], 3.08; 95% CI, 1.39-6.83), worsening sulcal grade (OR, 3.56; 95% CI,
1.04-12.2), and worsening ventricular grade (OR, 9.34; 95% CI, 1.24-70.2). In
cross-sectional analysis, of 969 participants, 35 (3.6%) had prevalent AF at the
time of the 2004 to 2006 MRI scan. Those with AF had greater odds of higher sulcal
(OR, 3.9; 95% CI, 1.7-9.1) and ventricular grade (OR, 2.4; 95% CI, 1.0-5.7) after
multivariable adjustment and no difference in white matter hyperintensity or total
brain volume. Conclusions- AF is independently associated with increase in
subclinical cerebral infarction and worsening sulcal and ventricular grade-
morphological changes associated with aging and dementia. More research is needed
to define the mechanisms underlying AF-related neurodegeneration.
AD - From the Cardiovascular Division, Department of Medicine, University of
Minnesota Medical Center, Minneapolis (J.P.B., L.Y.C.).
Division of Epidemiology and Community Health, School of Public Health, University
of Minnesota, Minneapolis (F.L.N., P.L.L.).
Department of Neurology, University of Mississippi Medical Center, Jackson (T.M.).
Department of Epidemiology and Prevention, Epidemiological Cardiology Research
Center, Wake Forest University School of Medicine, Winston-Salem, NC (E.Z.S.).
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD
(R.F.G.).
Department of Epidemiology, Rollins School of Public Health, Emory University,
Atlanta, GA (A.A.).
AN - 30908155
AU - Berman, J. P.
AU - Norby, F. L.
AU - Mosley, T.
AU - Soliman, E. Z.
AU - Gottesman, R. F.
AU - Lutsey, P. L.
AU - Alonso, A.
AU - Chen, L. Y.
C2 - PMC6662638
C6 - NIHMS1522228
DA - Apr
DO - 10.1161/strokeaha.118.024143
DP - NLM
ET - 2019/03/26
IS - 4
J2 - Stroke
KW - Aged
Atrial Fibrillation/*diagnostic imaging
Brain/*diagnostic imaging
Dementia/*diagnostic imaging
Female
Humans
Longitudinal Studies
Male
Organ Size/physiology
Risk Factors
White Matter/diagnostic imaging
*cognitive dysfunction
*dementia
*magnetic resonance imaging
*research
LA - eng
N1 - 1524-4628
Berman, Jeremy P
Norby, Faye L
Mosley, Thomas
Soliman, Elsayed Z
Gottesman, Rebecca F
Lutsey, Pamela L
Alonso, Alvaro
Chen, Lin Y
U01 HL096812/HL/NHLBI NIH HHS/United States
16EIA26410001/AHA/American Heart Association-American Stroke Association/United
States
HHSN268201700001I/HL/NHLBI NIH HHS/United States
K24 AG052573/AG/NIA NIH HHS/United States
Journal Article
Stroke. 2019 Apr;50(4):783-788. doi: 10.1161/STROKEAHA.118.024143.
PY - 2019
SN - 0039-2499 (Print)
0039-2499
SP - 783-788
ST - Atrial Fibrillation and Brain Magnetic Resonance Imaging Abnormalities
T2 - Stroke
TI - Atrial Fibrillation and Brain Magnetic Resonance Imaging Abnormalities
VL - 50
ID - 2939
ER -
TY - JOUR
AB - One hundred and eighty-two patients (100 females, 82 males) with mitral valve
prolapse (MVP) confirmed by echocardiography are described. Their ages range from
12 to 87 years (mean 48 years). The symptoms of breathlessness, pain in the chest
and palpitations were analysed. They were associated with left ventricular failure,
co-existing ischaemic heart disease and arrhythmias in some, but in a proportion
the symptoms were thought to be due to psychoneurosis. Seventy-two patients (40 per
cent) were referred because of complications of MVP. In 67 patients (37 per cent)
the condition was discovered by chance and in 43 patients (24 per cent) neurotic
symptoms had led to referral to hospital. A systolic click was heard in 117
patients (54 per cent); 41 patients (23 per cent) had a late systolic murmur and 30
patients (16 per cent) had a pansystolic murmur. The incidence of murmurs rose with
increasing age, and pansystolic murmurs were more frequent in males. Thirty-two
patients (18 per cent) had neither a click nor a murmur. Twenty-four patients (13
per cent) had associated supraventricular tachycardia and 22 (12 per cent) atrial
fibrillation. Twelve patients (7 per cent) had severe mitral incompetence and eight
(4 per cent) developed bacterial endocarditis. Only three patients had symptoms
suggesting cerebral ischaemia. Twelve patients (7 per cent) had associated aortic
incompetence. Twenty-two patients had had an inguinal hernia, the incidence in
males over 50 being 26 per cent. Twenty-six patients (14 per cent) had non-specific
T wave changes in the electrocardiogram. Echocardiography showed that 112 patients
(62 per cent) had mid-systolic buckling of the posterior leaflet and 70 patients
(38 per cent) had holosystolic prolapse. In view of the high incidence of
complications it is felt that the long-term prognosis not as good as has been
generally believed.
AN - 6611838
AU - Beton, D. C.
AU - Brear, S. G.
AU - Edwards, J. D.
AU - Leonard, J. C.
DA - Spring
DP - NLM
ET - 1983/01/01
IS - 206
J2 - The Quarterly journal of medicine
KW - Adolescent
Adult
Aged
Child
Dyspnea/etiology
Echocardiography
Electrocardiography
Endocarditis, Bacterial/etiology
Female
Heart Rate
Humans
Ischemic Attack, Transient/etiology
Male
Middle Aged
Mitral Valve Insufficiency/etiology
Mitral Valve Prolapse/complications/diagnosis/*physiopathology
Prognosis
LA - eng
N1 - Beton, D C
Brear, S G
Edwards, J D
Leonard, J C
Journal Article
England
Q J Med. 1983 Spring;52(206):150-64.
PY - 1983
SN - 0033-5622 (Print)
0033-5622
SP - 150-64
ST - Mitral valve prolapse: an assessment of clinical features, associated
conditions and prognosis
T2 - Q J Med
TI - Mitral valve prolapse: an assessment of clinical features, associated
conditions and prognosis
VL - 52
ID - 2746
ER -
TY - JOUR
AB - Over the last decade brain natriuretic peptide (BNP) emerged as a cardiac
hormone of clinical interest in diagnosis, prognosis and treatment of patients with
Heart Failure (HF). The diagnostic potential of BNP is now well established both in
patients with suspected HF as well as in patients with asymptomatic left
ventricular systolic dysfunction. The prognostic information obtained from BNP
levels in HF and acute myocardial infarction patients seems even more promising.
Nesiritide is a synthetic peptide, homologous to endogenous BNP. It is a balanced
vasodilator with diuretic and natriuretic properties. It decreases the elevated
levels of neurohormones resulting from activation of the sympathetic and renin-
aldosterone systems in HF. The results of clinical trials involving more than 2000
patients with decompensated HF are now available. In these trials nesiritide was
administered by single or repeated bolus injections, as well as by sustained
infusions. Nesiritide has been shown to produce a potent, dose-related vasodilator
effect that is rapid in onset and sustained during infusion. Balanced vasodilation
is reflected by decreases in systemic vascular resistance, pulmonary artery wedge
pressure and right atrial pressure. No tachyphylaxis has been observed in these
trials. Efficacy of nesiritide in the treatment of decompensated HF has been
demonstrated. Trials comparing nesiritide with conventional treatment of
decompensated HF showed that nesiritide compares favorably to standard agents. The
safety profile has been excellent with a dose-dependent hypotension as the major
side effect. Ventricular arrhythmia was not more frequent in patients treated with
nesiritide than with placebo. Thus, nesiritide appears to be useful as a first-line
agent in the treatment of patients with decompensated HF.
AD - Department of Internal Medicine, Servico de Medicina 3, Hospital S. João,
Faculdade de Medicina da Universidade do Porto, Unidad I&D Cardiovascular do Porto,
Portugal. pbettfer@esoterica.pt.
AN - 12070532
AU - Bettencourt, P.
DA - Winter
DO - 10.1111/j.1527-3466.2002.tb00080.x
DP - NLM
ET - 2002/06/19
IS - 1
J2 - Cardiovascular drug reviews
KW - Animals
Clinical Trials as Topic
Heart Failure/*drug therapy
Humans
Natriuretic Peptide, Brain/administration & dosage/adverse
effects/pharmacokinetics/pharmacology/*therapeutic use
Prognosis
Ventricular Dysfunction, Left/drug therapy/physiopathology
LA - eng
N1 - Bettencourt, Paulo
Journal Article
Review
United States
Cardiovasc Drug Rev. 2002 Winter;20(1):27-36. doi: 10.1111/j.1527-
3466.2002.tb00080.x.
PY - 2002
SN - 0897-5957 (Print)
0897-5957
SP - 27-36
ST - Brain natriuretic peptide (nesiritide) in the treatment of heart failure
T2 - Cardiovasc Drug Rev
TI - Brain natriuretic peptide (nesiritide) in the treatment of heart failure
VL - 20
ID - 3091
ER -
TY - JOUR
AB - The objective of this study was to investigate the prognostic significance of
12-lead electrocardiogram (ECG) patterns in a large multicenter cohort of patients
with hypertrophic cardiomyopathy; 1,004 consecutive patients with hypertrophic
cardiomyopathy and a recorded standard ECG (64% men, mean age 50 ± 16 years) were
evaluated at 4 Italian centers. The study end points were sudden cardiac death
(SCD) or surrogates, including appropriate implanted cardiac defibrillator
discharge and resuscitated cardiac arrest and major cardiovascular events
(including SCD or surrogates and death due to heart failure, cardioembolic stroke,
or heart transplantation). Prevalence of baseline electrocardiographic
characteristics was: normal ECG 4%, ST-segment depression 56%, pseudonecrosis waves
33%, "pseudo-ST-segment elevation myocardial infarction (STEMI)" pattern 17%, QRS
duration ≥120 ms 17%, giant inverted T waves 6%, and low QRS voltages 3%. During a
mean follow-up of 7.4 ± 6.8 years, 77 patients experienced SCD or surrogates and
154 patients experienced major cardiovascular events. Independent predictors of SCD
or surrogates were unexplained syncope (hazard ratio [HR] 2.5, 95% confidence
interval [CI] 1.4 to 4.5, p = 0.003), left ventricular ejection fraction <50% (HR
3.5, 95% CI 1.9 to 6.7, p = 0.0001), nonsustained ventricular tachycardia (HR 1.7,
95% CI 1.1 to 2.6, p = 0.027), pseudo-STEMI pattern (HR 2.3, 95% CI 1.4 to 3.8, p =
0.001), QRS duration ≥120 ms (HR 1.8, 95% CI 1.1 to 3.0, p = 0.033), and low QRS
voltages (HR 2.3, 95% CI 1.01 to 5.1, p = 0.048). Independent predictors of major
cardiovascular events were age (HR 1.02, 95% CI 1.01 to 1.03, p = 0.0001), LV
ejection fraction <50% (HR 3.73, 95% CI 2.39 to 5.83, p = 0.0001), pseudo-STEMI
pattern (HR 1.66, 95% CI 1.13 to 2.45, p = 0.010), QRS duration ≥120 ms (HR 1.69,
95% CI 1.16 to 2.47, p = 0.007), and prolonged QTc interval (HR 1.68, 95% CI 1.21
to 2.34, p = 0.002). In conclusion, a detailed qualitative and quantitative
electrocardiographic analyses provide independent predictors of prognosis that
could be integrated with the available score systems to improve the power of the
current model.
AD - Cardiology, Department of Experimental Diagnostic and Specialty Medicine,
Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Cardiothoracovascular Department, Referral Center for Myocardial Diseases, Azienda
Ospedaliera Universitaria Careggi, Florence, Italy.
Department of Clinical and Molecular Medicine, Sapienza University of Rome, Rome,
Italy.
Department of Cardiology, Monaldi Hospital, University of Naples, Naples, Italy.
Cardiology, Department of Experimental Diagnostic and Specialty Medicine, Alma
Mater Studiorum, University of Bologna, Bologna, Italy. Electronic address:
claudio.rapezzi@unibo.it.
AN - 27289293
AU - Biagini, E.
AU - Pazzi, C.
AU - Olivotto, I.
AU - Musumeci, B.
AU - Limongelli, G.
AU - Boriani, G.
AU - Pacileo, G.
AU - Mastromarino, V.
AU - Bacchi Reggiani, M. L.
AU - Lorenzini, M.
AU - Lai, F.
AU - Berardini, A.
AU - Mingardi, F.
AU - Rosmini, S.
AU - Resciniti, E.
AU - Borghi, C.
AU - Autore, C.
AU - Cecchi, F.
AU - Rapezzi, C.
DA - Aug 1
DO - 10.1016/j.amjcard.2016.05.023
DP - NLM
ET - 2016/06/13
IS - 3
KW - Adolescent
Adult
Age Factors
Aged
Cardiomyopathy, Hypertrophic/mortality/*physiopathology
Death, Sudden, Cardiac/*epidemiology
Electrocardiography
Female
Heart Failure/*mortality
Heart Transplantation
Humans
Italy/epidemiology
Male
Middle Aged
Stroke/*mortality
Stroke Volume
Syncope/epidemiology
Tachycardia, Ventricular/epidemiology/physiopathology
Young Adult
LA - eng
N1 - 1879-1913
Biagini, Elena
Pazzi, Chiara
Olivotto, Iacopo
Musumeci, Beatrice
Limongelli, Giuseppe
Boriani, Giuseppe
Pacileo, Giuseppe
Mastromarino, Vittoria
Bacchi Reggiani, Maria Letizia
Lorenzini, Massimiliano
Lai, Francesco
Berardini, Alessandra
Mingardi, Francesca
Rosmini, Stefania
Resciniti, Elvira
Borghi, Claudia
Autore, Camillo
Cecchi, Franco
Rapezzi, Claudio
Journal Article
Observational Study
United States
Am J Cardiol. 2016 Aug 1;118(3):432-9. doi: 10.1016/j.amjcard.2016.05.023. Epub
2016 May 15.
PY - 2016
SN - 0002-9149
SP - 432-9
ST - Usefulness of Electrocardiographic Patterns at Presentation to Predict Long-
term Risk of Cardiac Death in Patients With Hypertrophic Cardiomyopathy
T2 - Am J Cardiol
TI - Usefulness of Electrocardiographic Patterns at Presentation to Predict Long-
term Risk of Cardiac Death in Patients With Hypertrophic Cardiomyopathy
VL - 118
ID - 2494
ER -
TY - JOUR
AN - 6051551
AU - Bialostozky, L.
AU - Guerra Beltrán, S.
AU - Hurtado De Río, D.
DA - Jul-Aug
DP - NLM
ET - 1967/07/01
IS - 4
J2 - Archivos del Instituto de Cardiologia de Mexico
KW - Adult
Aged
Heart Block/surgery
Humans
Male
*Pacemaker, Artificial
Tachycardia/*etiology
LA - spa
N1 - Bialostozky, L
Guerra Beltrán, S
Hurtado De Río, D
Journal Article
Mexico
Arch Inst Cardiol Mex. 1967 Jul-Aug;37(4):489-92.
OP - Taquicardia ventricular secundaria a mal funcionamiento de marcapaso interno.
Informe de dos casos.
PY - 1967
SN - 0020-3785 (Print)
SP - 489-92
ST - [Ventricular tachycardia secondary to malfunctioning of internal pacemakers.
Report on 2 cases]
T2 - Arch Inst Cardiol Mex
TI - [Ventricular tachycardia secondary to malfunctioning of internal pacemakers.
Report on 2 cases]
VL - 37
ID - 2777
ER -
TY - JOUR
AB - WHAT IS KNOWN AND OBJECTIVE: Although inappropriate use of digoxin has been
described in various populations, a real-world evaluation of patterns of digoxin
prescription has not been well studied in patients with atrial fibrillation (AF).
The aim of this study was to identify prevalence, indications and appropriateness
of digoxin use in the general population of patients with non-valvular AF (NVAF) in
Turkey. METHODS: We included and classified patients from the RAMSES (ReAl-life
Multicentre Survey Evaluating Stroke prevention strategies in Turkey) study, a
prospective registry including 6273 patients with NVAF, on the basis of digoxin
use. After excluding the data of 73 patients whose medical history about digoxin
use or left ventricle function was absent, 6200 patients were included for the
final analysis. Digoxin use was considered inappropriate if patients did not have
left ventricular systolic dysfunction or symptomatic heart failure (HF). RESULTS
AND DISCUSSION: Digoxin was used in 1274 (20·5%) patients. Patients treated with
digoxin were older (71·4 ± 9·8 years vs. 69·2 ± 10·9 years, P < 0·001), more likely
to be female (58·8% vs. 55·9%, P = 0·019) and had more common comorbidities such as
HF (40·2% vs. 17·4%), diabetes (26·4% vs. 21·1%), coronary artery disease (35·3 vs.
27·6%) and persistent/permanent AF (93·4% vs. 78·4%; P < 0·001 for each
comparison). Of the 1274 patients, the indication of digoxin use was considered
inappropriate in 762 (59·8%). WHAT IS NEW AND CONCLUSION: Our findings show that
nearly one-fifth of the patients with NVAF were on digoxin therapy and nearly 60%
of these patients were receiving digoxin with inappropriate indications in a real-
world setting.
AD - Department of Cardiology, Faculty of Medicine, Mugla Sitki Kocman University,
Muğla, Turkey.
Department of Cardiology, Faculty of Medicine, Mugla Sitki Kocman University,
Muğla, Turkey. drvolkandogan@hotmail.com.
Department of Cardiology, Faculty of Medicine, Sivas Cumhuriyet University, Sivas,
Turkey.
Department of Cardiology, Kahramanmaraş Necip Fazıl State Hospital, Kahramanmaraş,
Turkey.
Department of Cardiology, Trabzon Ahi Evren Chest Cardiovascular Surgery Education
and Research Hospital, Trabzon, Turkey.
Department of Cardiology, Fethiye State Hospital, Muğla, Turkey.
Department of Cardiology, Elazığ Education and Research Hospital, Elazig, Turkey.
Department of Cardiology, Burdur State Hospital, Burdur, Turkey.
Department of Cardiology, İskilip Atıf Hoca State Hospital, İskilip, Turkey.
Department of Cardiology, Samsun Education and Research Hospital, Samsun, Turkey.
Kartal Kosuyolu Heart Education and Research Hospital, Istanbul, Turkey.
AN - 27671101
AU - Biteker, M.
AU - Başaran, Ö
AU - Dogan, V.
AU - Beton, O.
AU - Tekinalp, M.
AU - Çağrı Aykan, A.
AU - Kalaycıoğlu, E.
AU - Bolat, I.
AU - TaŞar, O.
AU - Şafak, Ö
AU - Kalçık, M.
AU - Yaman, M.
AU - Kırma, C.
DA - Dec
DO - 10.1111/jcpt.12460
DP - NLM
ET - 2016/10/28
IS - 6
J2 - Journal of clinical pharmacy and therapeutics
KW - Aged
Comorbidity
Digoxin/*therapeutic use
Female
Heart Failure/drug therapy
Heart Ventricles/drug effects
Humans
Male
Prospective Studies
Stroke/drug therapy
Turkey
*congestive heart failure
*digoxin
LA - eng
N1 - 1365-2710
Biteker, M
Başaran, Ö
Dogan, V
Beton, O
Tekinalp, M
Çağrı Aykan, A
Kalaycıoğlu, E
Bolat, I
TaŞar, O
Şafak, Ö
Kalçık, M
Yaman, M
Kırma, C
Clinical Trial
Journal Article
Multicenter Study
Observational Study
England
J Clin Pharm Ther. 2016 Dec;41(6):711-717. doi: 10.1111/jcpt.12460. Epub 2016 Sep
27.
PY - 2016
SN - 0269-4727
SP - 711-717
ST - Real-life use of digoxin in patients with non-valvular atrial fibrillation:
data from the RAMSES study
T2 - J Clin Pharm Ther
TI - Real-life use of digoxin in patients with non-valvular atrial fibrillation:
data from the RAMSES study
VL - 41
ID - 2576
ER -
TY - JOUR
AB - This study prospectively evaluated the role of transesophageal
echocardiography (TEE) in screening for atrial thrombi before electrical
cardioversion in 40 nonanticoagulated patients with nonvalvular atrial fibrillation
(n = 33) or atrial flutter (n = 7). Transthoracic echocardiography did not detect
atrial thrombus in any patient. TEE detected left atrial appendage thrombi in five
patients (12%, p = 0.03), significantly associated with left ventricular systolic
dysfunction (p = 0.02) and left atrial spontaneous echo contrast (p = 0.04).
Cardioversion was cancelled in the five patients with thrombi and in two patients
with spontaneous reversion before planned cardioversion. Cardioversion was
successful in 25 (76%) of the 33 remaining patients. Cerebral embolism occurred 24
hours after successful cardioversion in one patient with atrial fibrillation and
left ventricular dysfunction, who had left atrial spontaneous echo contrast, but no
thrombus was detected by TEE before cardioversion. Repeat TEE after embolism showed
a fresh left atrial appendage thrombus and increased left atrial spontaneous echo
contrast. These results indicate that TEE improves the detection of left atrial
appendage thrombi in candidates for cardioversion, in whom the procedure may be
deferred. However, the exclusion by TEE of preexisting atrial thrombi before
cardioversion does not eliminate the risk of embolism after cardioversion because
of persistent atrial stasis and de novo thrombosis.
AD - Department of Cardiovascular Medicine, Prince Henry Hospital, Sydney,
Australia.
AN - 8338008
AU - Black, I. W.
AU - Hopkins, A. P.
AU - Lee, L. C.
AU - Walsh, W. F.
DA - Aug
DO - 10.1016/0002-8703(93)91054-i
DP - NLM
ET - 1993/08/01
IS - 2
KW - Anticoagulants
Atrial Fibrillation/*diagnostic imaging/therapy
Atrial Flutter/*diagnostic imaging/therapy
*Electric Countershock
Embolism/prevention & control
Female
Heart Diseases/*diagnostic imaging/epidemiology
Humans
Male
Middle Aged
Prospective Studies
Risk Factors
Thrombosis/*diagnostic imaging/epidemiology
LA - eng
N1 - Black, I W
Hopkins, A P
Lee, L C
Walsh, W F
Journal Article
United States
Am Heart J. 1993 Aug;126(2):375-81. doi: 10.1016/0002-8703(93)91054-i.
PY - 1993
SN - 0002-8703 (Print)
0002-8703
SP - 375-81
ST - Evaluation of transesophageal echocardiography before cardioversion of atrial
fibrillation and flutter in nonanticoagulated patients
T2 - Am Heart J
TI - Evaluation of transesophageal echocardiography before cardioversion of atrial
fibrillation and flutter in nonanticoagulated patients
VL - 126
ID - 2830
ER -
TY - JOUR
AB - The Atrial Fibrillation (AF) Follow-up Investigation of Rhythm Management
(AFFIRM) and Rate Control versus Electrical Cardioversion for Persistent Atrial
Fibrillation Study (RACE) Trials evaluated strategies of rate control or rhythm
control in atrial fibrillation. AFFIRM enrolled patients with recent onset AF, and
at entry over half of all patients were in sinus rhythm. At any point in the trial,
the achieved difference in cardiac rhythm was likely only about 30%. In RACE all
patients were entered in AF, and at the end of the study, sinus rhythm was present
in 10% vs 39%. The strategy of rate control was non-inferior to the rhythm control
strategy in both trials, and permits consideration of rate control as primary
therapy. However, the actual differences in rhythm were relatively small, and do
not allow the conclusion that maintenance of sinus rhythm is inferior to non-
maintenance. Current guidelines recommend that patients with paroxysmal AF receive
warfarin if they have risk factors for stroke. This is supported by data from
AFFIRM. Most strokes in AFFIRM occurred either during subtherapeutic INR, or after
cessation of warfarin. Since more patients in the rhythm control arm of AFFIRM
discontinued warfarin, it is possible that asymptomatic recurrences of paroxysmal
AF fostered clot development and embolization. We cannot answer from the data
available whether or not it is safe to discontinue anticoagulation if all episodes
of AF are suppressed. Among the reasons that AF is associated with increased
mortality may be that it encourages development of congestive heart failure or
progressive left ventricular dysfunction. Congestive heart failure occurrence was
monitored in both trials, and occurred at a rate of 2-5% without significant
differences between rate and rhythm arms. In patients with heart failure at entry,
a mortality trend in AFFIRM favored the rhythm control arm. The issue of
survivorship and rhythm control in AF in congestive heart failure is undergoing
further testing.
AD - Mayo Clinic Jacksonville, Division of Cardiovascular Diseases, Florida, USA.
blackshear.joseph@mayo.edu
AN - 15071255
AU - Blackshear, J. L.
AU - Safford, R. E.
DA - Dec
DO - 10.1023/b:Cepr.0000023140.38226.75
DP - NLM
ET - 2004/04/09
IS - 4
J2 - Cardiac electrophysiology review
KW - Anticoagulants/therapeutic use
Atrial Fibrillation/drug therapy/physiopathology/*therapy
Humans
LA - eng
N1 - Blackshear, Joseph L
Safford, Robert E
AFFIRM trial
RACE trial
Journal Article
Review
United States
Card Electrophysiol Rev. 2003 Dec;7(4):366-9. doi:
10.1023/B:CEPR.0000023140.38226.75.
PY - 2003
SN - 1385-2264 (Print)
1385-2264
SP - 366-9
ST - AFFIRM and RACE trials: implications for the management of atrial
fibrillation
T2 - Card Electrophysiol Rev
TI - AFFIRM and RACE trials: implications for the management of atrial
fibrillation
VL - 7
ID - 2551
ER -
TY - JOUR
AB - AIMS: Ventricular arrhythmia is the main cause of sudden cardiac death.
Intracardiac strain, myocardial and extracellular matrix remodelling, and
subsequent myocardial fibrosis are involved in arrhythmia pathogenesis. The present
study investigates the relationship between cardiac fibrosis [procollagen type I
aminoterminal peptide (PINP), procollagen type III aminoterminal peptide (PIIINP),
TIMP1, membrane metalloproteinase I], pressure overload [brain natriuretic peptide
(BNP)] inflammation [high sensitivity (hs)-C-reactive protein] serum markers, and
the incidence of ventricular tachycardia (VT) in implantable cardioverter-
defibrillators (ICD) recipients. METHODS AND RESULTS: Serum markers were collected
in 121 patients implanted for spontaneous sustained VT and a prior history of
myocardial infarction. VT incidence was obtained during ICD interrogation. Over a 1
year period, 38 patients (31%) experienced at least 1 VT. In a multivariate
analysis, a left ventricular ejection fraction <0.35 (OR = 2.19, 95%CI 1.00-4.79, P
= 0.049), an increased serum BNP (OR = 3.75, 95%CI 1.46-9.67, P = 0.014), an
increased hs-C-reactive protein (OR = 3.2, 95%CI 1.26-8.10, P = 0.006), an
increased PINP (OR = 3.71, 95%CI 1.40-9.88, P = 0.009), and a decreased PIIINP (OR
= 0.21, 95%CI 0.08-0.59, P = 0.003) were associated with a higher VT incidence.
CONCLUSION: In coronary artery disease patients: (1) BNP is not only a marker of
left ventricular dysfunction, but also a marker of VT; (2) combined 'high PINP and
low PIIINP' is a strong VT marker; and 3) inflammatory process is involved in VT
pathogenesis.
AD - Département de Cardiologie, CHU de Nancy, Hôpital de Brabois, Rue du Morvan,
54511, Vandoeuvre-lès-Nancy, France. h.blangy@chu-nancy.fr
AN - 17526509
AU - Blangy, H.
AU - Sadoul, N.
AU - Dousset, B.
AU - Radauceanu, A.
AU - Fay, R.
AU - Aliot, E.
AU - Zannad, F.
DA - Sep
DO - 10.1093/europace/eum102
DP - NLM
ET - 2007/05/29
IS - 9
J2 - Europace : European pacing, arrhythmias, and cardiac electrophysiology :
journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular
electrophysiology of the European Society of Cardiology
KW - Adult
Aged
Aged, 80 and over
C-Reactive Protein/*biosynthesis
Female
Humans
Inflammation
Male
Middle Aged
Myocardial Infarction/*blood/*therapy
Procollagen/*blood
Prospective Studies
Research Design
Risk
Tachycardia, Ventricular/*blood/*diagnosis
LA - eng
N1 - Blangy, Hugues
Sadoul, Nicolas
Dousset, Brigitte
Radauceanu, Anca
Fay, Renaud
Aliot, Etienne
Zannad, Faiez
Journal Article
England
Europace. 2007 Sep;9(9):724-9. doi: 10.1093/europace/eum102. Epub 2007 May 24.
PY - 2007
SN - 1099-5129 (Print)
1099-5129
SP - 724-9
ST - Serum BNP, hs-C-reactive protein, procollagen to assess the risk of
ventricular tachycardia in ICD recipients after myocardial infarction
T2 - Europace
TI - Serum BNP, hs-C-reactive protein, procollagen to assess the risk of
ventricular tachycardia in ICD recipients after myocardial infarction
VL - 9
ID - 2940
ER -
TY - JOUR
AB - INTRODUCTION: Acute cerebral injuries, such as cerebral ischemic or
hemorrhagic events, have been repeatedly correlated with sudden electrocardiogram
(ECG) changes, such as cardiac arrhythmias, QT prolongation, and T-wave inversion
(the "cerebral T-wave"). Injuries to the insular cortex have been reported in the
literature to result in such changes, possibly due to increased sympathetic tone to
the cardiac system. CASE REPORT: A 65-year-old gentleman presented with an acute
right middle cerebral artery territory infarction, and was found to have ECG
abnormalities and left ventricular dysfunction, which improved after the acute
phase of the stroke. CONCLUSIONS: Acute ischemic infarcts, particularly to the
right insular cortex, can result in ECG abnormalities, such as QT prolongation and
T-wave inversion, as well as acute systolic heart failure; all of which may be
reversible after the acute phase of the stroke.
AD - Mayo Clinic in Scottsdale, Scottsdale, AZ.
AN - 29953038
AU - Blech, B.
AU - O'Carroll, C.
DA - Jul
DO - 10.1097/nrl.0000000000000185
DP - NLM
ET - 2018/06/29
IS - 4
J2 - The neurologist
KW - Acute Disease
Aged
Electrocardiography
Heart Failure, Systolic/*diagnosis/etiology
Humans
Infarction, Middle Cerebral Artery/complications/*diagnosis
Long QT Syndrome/*diagnosis/etiology
Male
Ventricular Dysfunction, Left/*diagnosis/etiology
LA - eng
N1 - 2331-2637
Blech, Benzion
O'Carroll, Cumara
Case Reports
Journal Article
United States
Neurologist. 2018 Jul;23(4):135-137. doi: 10.1097/NRL.0000000000000185.
PY - 2018
SN - 1074-7931
SP - 135-137
ST - Acute Right Middle Cerebral Artery Occlusion Resulting in Acute Systolic
Heart Failure, Cerebral T-Waves, and QTc Prolongation: A Case Report
T2 - Neurologist
TI - Acute Right Middle Cerebral Artery Occlusion Resulting in Acute Systolic
Heart Failure, Cerebral T-Waves, and QTc Prolongation: A Case Report
VL - 23
ID - 2388
ER -
TY - JOUR
AB - Recently disorders of sinus node function have found increasing interest in
clinical medicine thanks to new diagnostic and therapeutic developments. This paper
represents a comprehensive review of these conditions, combined under the name
"Sick Sinus Syndrome" (SSS). Besides a detailed analysis of 63 cases seen at our
institution, the results of other groups are compared and extensively discussed.
The clinical picture of the SSS is characterized by a wide variety of bradycardiac
and tachycardic atrial arrhythmias, occurring separately or in combination. These
can be classified in three subgroups: Patients with exclusive sinus bradycardia;
patients with sinoatrial exit block or transient episodes of sinus arrest with or
without AV escape rhythms; and finally patients with the bradycardia/tachycardia-
syndrome, which are complicated by additional atrial tachyarrhythmias. The
symptomatology of the SSS is multiform and extends from symptomless cases and those
with only general signs of reduced cardiac function to patients with recurrent
severe syncopal attacks which may lead to cerebral damage and even death. Besides
the typical history, the diagnosis of the SSS primarily rests upon the ECG,
especially the long term ECG recorded continuously on a 24 hrs. tape (Holter
technique). Also the exercise ECG is of some value, characteristically showing an
inadequate increase in the sinus rate, sometimes with AV escape systoles and
-rhythms. In addition various provocative tests have been devised which are of help
to differentiate between a pathologic and a normal sinus node function. Among these
the determination of the sinus node recovery time following overdrive atrial pacing
has gained wide acceptance. In most cases the exact etiology of the SSS is not
known. In addition to coronary and inflammatory heart diseases a primarily
degenerative lesion of the sinus node, comparable to cases with "primary heart
block" are discussed. There is also a remarkably frequent past history diththeria.
Rarer causes of the condition represent cases with cardiomyopathy, thyreotoxic
heart disease, collagen and other disorders and also a familial manifestation of
the SSS has been described. Therapeutically, pharmacologic treatment with
vagolytic, beta-adrenergic or the common antiarrhythmic drugs is often
unsuccessful, especially in the treatment of the Brady-Tachy-Syndrome. Digitalis
glycosides, however, are frequently of some value, as they represent an effective
prophylactic agent against atrial tachyarrhythmias without prolonging the sinus
node recovery time or reducing significantly the sinus rate. While a few patients
do not require any treatment, an artificial cardiac pacemaker has to be inserted in
most cases. Atrial stimulation may be superior to ventricular on-demand pacing in
some patients, and also a special system for the treatment of the SSS combined with
significant AV block (binodal disease) has been designed, the bifocal sequential
pacemaker.
AN - 1099830
AU - Blömer, H.
AU - Wirtzfeld, A.
AU - Delius, W.
AU - Sebening, H.
DA - Aug
DP - NLM
ET - 1975/08/01
IS - 8
KW - Age Factors
Aged
Arrhythmias, Cardiac/*diagnosis/etiology/therapy
Atrial Flutter/diagnosis
Atropine
Bradycardia/diagnosis
Chronic Disease
Coronary Disease/complications
Electrocardiography
Exercise Test
Female
Heart Rate
Humans
Hyperthyroidism/complications
Male
Middle Aged
Prognosis
Rheumatic Fever/complications
Sex Factors
*Sinoatrial Node
Syncope/etiology
Tachycardia/diagnosis
LA - ger
N1 - Blömer, H
Wirtzfeld, A
Delius, W
Sebening, H
English Abstract
Journal Article
Review
Germany
Z Kardiol. 1975 Aug;64(8):697-721.
OP - Das Sinusknoten-Syndrom.
PY - 1975
SN - 0300-5860 (Print)
0300-5860
SP - 697-721
ST - [Sinus node syndrome]
T2 - Z Kardiol
TI - [Sinus node syndrome]
VL - 64
ID - 2823
ER -
TY - JOUR
AB - OBJECTIVE: To investigate the diagnostic yield of prehospital ECG monitoring
provided by emergency medical services in the case of suspected stroke. METHODS:
Consecutive patients with acute stroke admitted to our tertiary stroke center via
emergency medical services and with available prehospital ECG were prospectively
included during a 12-month study period. We assessed prehospital ECG recordings and
compared the results to regular 12-lead ECG on admission and after continuous ECG
monitoring at the stroke unit. RESULTS: Overall, 259 patients with prehospital ECG
recording were included in the study (90.3% ischemic stroke, 9.7% intracerebral
hemorrhage). Atrial fibrillation (AF) was detected in 25.1% of patients, second-
degree or greater atrioventricular block in 5.4%, significant ST-segment elevation
in 5.0%, and ventricular ectopy in 9.7%. In 18 patients, a diagnosis of new-onset
AF with direct clinical consequences for the evaluation and secondary prevention of
stroke was established by the prehospital recordings. In 2 patients, the AF
episodes were limited to the prehospital period and were not detected by ECG on
admission or during subsequent monitoring at the stroke unit. Of 126 patients
(48.6%) with relevant abnormalities in the prehospital ECG, 16.7% received medical
antiarrhythmic therapy during transport to the hospital, and 6.4% were transferred
to a cardiology unit within the first 24 hours in the hospital. CONCLUSIONS: In a
selected cohort of patients with stroke, the in-field recordings of the ECG
detected a relevant rate of cardiac arrhythmia. The results can add to the in-
hospital evaluation and should be considered in prehospital care of acute stroke.
AD - From the Departments of Neurology (T.B., B.K., M. Kopp, N.K., S.H., S.S., M.
Köhrmann) and Cardiology (M.A.), Universitätsklinikum Erlangen; and Department of
Neurology (M. Köhrmann), Universitätsklinikum Essen, Germany. Tobias.Bobinger@uk-
erlangen.de.
From the Departments of Neurology (T.B., B.K., M. Kopp, N.K., S.H., S.S., M.
Köhrmann) and Cardiology (M.A.), Universitätsklinikum Erlangen; and Department of
Neurology (M. Köhrmann), Universitätsklinikum Essen, Germany.
AN - 28432194
AU - Bobinger, T.
AU - Kallmünzer, B.
AU - Kopp, M.
AU - Kurka, N.
AU - Arnold, M.
AU - Heider, S.
AU - Schwab, S.
AU - Köhrmann, M.
DA - May 16
DO - 10.1212/wnl.0000000000003940
DP - NLM
ET - 2017/04/23
IS - 20
J2 - Neurology
KW - Aged
Aged, 80 and over
Atrial Fibrillation/complications/diagnostic imaging/physiopathology
Brain Ischemia/complications/diagnostic imaging/physiopathology
Cerebral Hemorrhage/complications/diagnostic imaging/physiopathology
*Emergency Medical Services
Female
Humans
Male
Prevalence
Prospective Studies
Stroke/complications/*diagnostic imaging/physiopathology
LA - eng
N1 - 1526-632x
Bobinger, Tobias
Kallmünzer, Bernd
Kopp, Markus
Kurka, Natalia
Arnold, Martin
Heider, Stefan
Schwab, Stefan
Köhrmann, Martin
Journal Article
United States
Neurology. 2017 May 16;88(20):1894-1898. doi: 10.1212/WNL.0000000000003940. Epub
2017 Apr 21.
PY - 2017
SN - 0028-3878
SP - 1894-1898
ST - Diagnostic value of prehospital ECG in acute stroke patients
T2 - Neurology
TI - Diagnostic value of prehospital ECG in acute stroke patients
VL - 88
ID - 2411
ER -
TY - JOUR
AB - BACKGROUND: Early repolarization pattern (ER) gained attention as a risk
factor for ventricular arrhythmia and sudden cardiac death in the general
population. While electrocardiographic abnormalities are frequent findings in
stroke patients, data on ER pattern in this population are lacking. METHODS: We
assessed the prevalence of ER pattern in consecutive acute stroke patients at a
tertiary stroke center. Functional outcome after 90 days was analyzed to determine
the effect of an ER pattern on mortality. Multivariate logistic regression analysis
was used to identify factors associated with an ER pattern. RESULTS: Out of 1141
consecutive stroke patients 771 patients remained for analysis after application of
exclusion criteria. ER was observed in 62 (8.04%) patients. ER was more prevalent
among subjects with intracerebral and subarachnoidal hemorrhage (13.0%) than among
patients with ischemic stroke (7.0%; p = 0.024). Multiple regression analysis
revealed QRS-duration (OR 0.972 95% CI 0.950-0.994, p = 0.012), QT-duration (OR
1.009, 95% CI 1.004-1.014, p = 0.001) and mechanical ventilation on admission (OR
0.320, 95% CI 0.136-0.752, p = 0.009) as independent predictors for ER. Overall ER
on admission was not associated with increased mortality at 3-month follow-up (ER
11.3% vs. non-ER 9.2%; p = 0.582). CONCLUSIONS: ER is frequently found among
patients with acute cerebrovascular events and is more prevalent in patients with
hemorrhagic compared to ischemic events. Our study yields no evidence that ER is
associated with worse outcome or mortality after stroke.
AD - Department of Neurology, Universitätsklinikum Erlangen-Nuremberg,
Schwabachanlage 6, 91054, Erlangen, Germany, tobias.bobinger@uk-erlangen.de.
AN - 25707765
AU - Bobinger, T.
AU - Kopp, M.
AU - Kurka, N.
AU - Arnold, M.
AU - Hilz, M. J.
AU - Huttner, H. B.
AU - Schwab, S.
AU - Köhrmann, M.
DA - Aug
DO - 10.1007/s00392-015-0831-6
DP - NLM
ET - 2015/02/25
IS - 8
J2 - Clinical research in cardiology : official journal of the German Cardiac
Society
KW - Action Potentials
Aged
Arrhythmias, Cardiac/*diagnosis/*epidemiology/mortality/physiopathology
Brain Ischemia/diagnosis/*epidemiology/mortality/physiopathology/therapy
Female
Germany/epidemiology
Heart Conduction System/*physiopathology
Humans
Intracranial Hemorrhages/diagnosis/*epidemiology/mortality/physiopathology/therapy
Logistic Models
Male
Middle Aged
Odds Ratio
Prevalence
Prognosis
Prospective Studies
Risk Assessment
Risk Factors
Stroke/diagnosis/*epidemiology/mortality/physiopathology/therapy
Time Factors
LA - eng
N1 - 1861-0692
Bobinger, Tobias
Kallmünzer, Bernd
Kopp, Markus
Kurka, Natalia
Arnold, Martin
Hilz, Max-Josef
Huttner, Hagen B
Schwab, Stefan
Köhrmann, Martin
Journal Article
Observational Study
Germany
Clin Res Cardiol. 2015 Aug;104(8):666-71. doi: 10.1007/s00392-015-0831-6. Epub 2015
Feb 25.
PY - 2015
SN - 1861-0684
SP - 666-71
ST - Prevalence and impact on outcome of electrocardiographic early repolarization
patterns among stroke patients: a prospective observational study
T2 - Clin Res Cardiol
TI - Prevalence and impact on outcome of electrocardiographic early repolarization
patterns among stroke patients: a prospective observational study
VL - 104
ID - 2372
ER -
TY - JOUR
AB - Atrial pacing (AP), despite its beneficial hemodynamic and antiarrhythmic
effect, is still an underused mode of stimulation. The main purpose of this study
was to evaluate the long-term results of AP. Sixty four patients (pts) with sinus
node disease (28 male and 36 female: mean age 54.2; range: 44-88 years), 3.2% of
the total implantation at our clinic were treated with AP between 1982-96. Criteria
for atrial pacing were: no AV block in the history, no AV-block during carotid
sinus massage, Wenckebach point > 130/min, left atrium < 50 mm, left ventricular EF
> 40%. The indication for pacing was predominant sinus bradycardia (SB) in 34 pts
and tachycardia-bradycardia syndrome (TBS) in 30 pts. Pts with TBS were on
antiarrhythmic treatment, while most pts with SB received no antiarrhythmic drugs.
All the pts were checked up at every 3-6 month. Sixty-two pts were followed for 3-
154 (mean: 67) months, two pts were lost for follow-up. Repeated lead dislodgment
occurred in two pts, which made a pacing mode change necessary. Four pts died
during the follow-up period for non-cardiac reasons. At the end of the follow-up
period the data of 60 pts were available for evaluation (33 pts with SB, 27 pts
with TBS). All the pts with SB were in sinus rhythm, and no patient developed AV
block by the end of the follow-up period. Seven out of 27 pts with TBS developed
chronic atrial fibrillation, 3 out of them suffered a cerebral embolism; the
remaining 20 pts were in sinus rhythm, and the number of paroxysmal attacks
decreased significantly, which improved their quality of life significantly. Three
pts in this group developed a temporary complete AV block, which regressed with
decreasing the dosage of antiarrhythmic drugs. Atrial pacing is proved to be a safe
and reliable treatment for sick sinus syndrome. Proper patient selection is crucial
in preventing the development of AV conduction disturbance. Atrial stimulation had
a satisfactory long-term antiarrhythmic effect in pts with sick sinus syndrome
(SSS).
AD - Cardiovascular Center, Imre Haynal University of Health Sciences, Budapest,
Hungary.
AN - 9474681
AU - Böhm, A.
AU - Pintér, A.
AU - Székely, A.
AU - Préda, I.
DA - Jan
DO - 10.1111/j.1540-8159.1998.tb01097.x
DP - NLM
ET - 1998/02/25
IS - 1 Pt 2
J2 - Pacing and clinical electrophysiology : PACE
Arrhythmia, Sinus/*therapy
Cardiac Pacing, Artificial/*methods
Evaluation Studies as Topic
Female
Follow-Up Studies
Heart Atria
Humans
Male
Middle Aged
Patient Selection
Sick Sinus Syndrome/*therapy
Time Factors
LA - eng
N1 - Böhm, A
Pintér, A
Székely, A
Préda, I
Journal Article
United States
Pacing Clin Electrophysiol. 1998 Jan;21(1 Pt 2):246-9. doi: 10.1111/j.1540-
8159.1998.tb01097.x.
PY - 1998
SN - 0147-8389 (Print)
0147-8389
SP - 246-9
ST - Clinical observations with long-term atrial pacing
T2 - Pacing Clin Electrophysiol
TI - Clinical observations with long-term atrial pacing
VL - 21
ID - 2923
ER -
TY - JOUR
AB - From July 1986 to January 1991, 123 patients with Wolff-Parkinson-White
syndrome underwent operation for ablation of aberrant conduction pathways. There
were 85 male and 38 female patients ranging in age from 11 months to 68 years.
Associated anomalies included Ebstein's anomaly, sudden death syndrome, coronary
artery disease, cardiomyopathy, abdominal aortic aneurysm, neurofibromatosis, other
arrhythmias, or other complex congenital heart disease. Forty-one patients had
multiple accessory pathways. Operative results showed a 7% initial failure rate,
which dropped to 3% after reoperation. One patient had undergone previous operation
for Wolff-Parkinson-White syndrome at another institution. Procedures performed
concomitantly included mitral or tricuspid valve repair or replacement (6), right
ventricular conduit replacement, subaortic resection, Fontan repair, corrected
transposition repair, coronary artery bypass, and placement of an automatic
internal cardioverter defibrillator. There was no operative mortality. Late follow-
up is 27 +/- 16 months, and complications included mitral regurgitation and
myocardial infarction. By comparison, in the last 12 months 124 patients with the
Wolff-Parkinson-White syndrome underwent catheter ablation using radiofrequency
current. There were 9 patients with multiple pathways. One hundred twelve patients
(90%) had all accessory atrioventricular connections ablated and have remained free
of symptomatic tachycardia. There have been 12 failures (10%), of which 5 have had
operation and 7 are being treated medically. Mean follow-up is 7 +/- 5 months, and
complications included circumflex coronary artery occlusion, excessive bleeding,
valve perforation, and cerebral vascular accident.(ABSTRACT TRUNCATED AT 250 WORDS)
AD - Section of Thoracic Surgery, University of Michigan Medical Center, Ann
Arbor.
AN - 1898133
AU - Bolling, S. F.
AU - Morady, F.
AU - Calkins, H.
AU - Kadish, A.
AU - de Buitleir, M.
AU - Langberg, J.
AU - Dick, M.
AU - Lupinetti, F. M.
AU - Bove, E. L.
DA - Sep
DO - 10.1016/0003-4975(91)90906-7
DP - NLM
ET - 1991/09/01
IS - 3
KW - Adolescent
Adult
Aged
Child
Child, Preschool
*Electrocoagulation/adverse effects/methods
Female
Follow-Up Studies
Humans
Infant
Male
Middle Aged
Radio Waves
Wolff-Parkinson-White Syndrome/*surgery
LA - eng
N1 - Bolling, S F
Morady, F
Calkins, H
Kadish, A
de Buitleir, M
Langberg, J
Dick, M
Lupinetti, F M
Bove, E L
Comparative Study
Journal Article
Netherlands
Ann Thorac Surg. 1991 Sep;52(3):461-8. doi: 10.1016/0003-4975(91)90906-7.
PY - 1991
SN - 0003-4975 (Print)
0003-4975
SP - 461-8
ST - Current treatment for Wolff-Parkinson-White syndrome: results and surgical
implications
TI - Current treatment for Wolff-Parkinson-White syndrome: results and surgical
implications
VL - 52
ID - 3022
ER -
TY - JOUR
AB - BACKGROUND AND PURPOSE: Emery-Dreifuss muscular dystrophy (EDMD) is a rare
inherited disorder associated with cardiac involvement. We investigated the
spectrum and relevance of the cardiac manifestations of EDMD, focusing on
bradyarrhythmias and tachyarrhythmias (including atrial fibrillation/flutter),
embolic stroke, and heart failure. METHODS AND RESULTS: Eighteen patients (age
42.8+/-19.6 years) with genetically confirmed X-linked (n=10, including 3 carriers)
or autosomal dominant (n=8) EDMD were followed for a period ranging from 1 to 30
years in a research center for neuromuscular diseases and in a university
cardiological department. Pacemakers were required by 10 of 18 (56%) patients for
bradyarrhythmia, and related complications occurred in 3 of 10 (30%) cases. Atrial
fibrillation/flutter developed in 11 of 18 (61%) patients, with atrial standstill
subsequently occurring in 5 of 11 (45%) cases and embolic stroke (most often
disabling) in 4 of 11 (36%). Heart failure requiring transplantation occurred in 1
of 18 (6%) patients, and asymptomatic left ventricular dysfunction in a further 3
(17%). No relationship was evident between neuromuscular impairment and cardiac
involvement. CONCLUSIONS: Both X-linked and autosomal dominant EDMD patients risk
not only bradyarrhythmia (requiring pacemaker implant) but also atrial
fibrillation/flutter, which often anticipates atrial standstill and can cause
disabling embolic stroke at a relatively young age. Antithromboembolic prophylaxis
has to be recommended in EDMD patients with atrial fibrillation/flutter or atrial
standstill. With careful monitoring, survival after pacemaker implant may be long.
Heart failure, which seems to occur only in a minority of patients, may be severe.
AD - Institute of Cardiology, Policlinico S. Orsola-Malpighi, University of
Bologna, Italy. cardio1@almadns.unibo.it
AN - 12649505
AU - Boriani, G.
AU - Gallina, M.
AU - Merlini, L.
AU - Bonne, G.
AU - Toniolo, D.
AU - Amati, S.
AU - Biffi, M.
AU - Martignani, C.
AU - Frabetti, L.
AU - Bonvicini, M.
AU - Rapezzi, C.
AU - Branzi, A.
DA - Apr
DO - 10.1161/01.Str.0000064322.47667.49
DP - NLM
ET - 2003/03/22
IS - 4
J2 - Stroke
KW - Adult
Aged
Atrial Fibrillation/diagnosis/epidemiology
Atrial Flutter/diagnosis/epidemiology
Bradycardia/diagnosis/therapy
Child
Child, Preschool
Electrocardiography
Female
Follow-Up Studies
Heart Diseases/*diagnosis/diagnostic imaging/therapy
Heart Failure/diagnosis/epidemiology
Humans
Infant
Male
Middle Aged
Muscular Dystrophy, Emery-Dreifuss/complications/*diagnosis/*therapy
*Pacemaker, Artificial/adverse effects
Pedigree
Thromboembolism/complications/epidemiology
Ultrasonography
Ventricular Dysfunction, Left/diagnosis/epidemiology
LA - eng
N1 - 1524-4628
Boriani, Giuseppe
Gallina, Margherita
Merlini, Luciano
Bonne, Gisèle
Toniolo, Daniela
Amati, Silvia
Biffi, Mauro
Martignani, Cristian
Frabetti, Lorenzo
Bonvicini, Marco
Rapezzi, Claudio
Branzi, Angelo
Journal Article
United States
Stroke. 2003 Apr;34(4):901-8. doi: 10.1161/01.STR.0000064322.47667.49. Epub 2003
Mar 20.
PY - 2003
SN - 0039-2499
SP - 901-8
ST - Clinical relevance of atrial fibrillation/flutter, stroke, pacemaker implant,
and heart failure in Emery-Dreifuss muscular dystrophy: a long-term longitudinal
study
T2 - Stroke
TI - Clinical relevance of atrial fibrillation/flutter, stroke, pacemaker implant,
and heart failure in Emery-Dreifuss muscular dystrophy: a long-term longitudinal
study
VL - 34
ID - 2506
ER -
TY - JOUR
AB - Sinus node disease (SND), a common indication to implant a pacemaker, is
frequently associated with atrial fibrillation (AF), either at implantation
(paroxysmal AF) or during follow-up, which often evolves to persistent or permanent
AF. Pacemakers with an atrial lead allow continuous monitoring of the atrial rhythm
and enable detection of the burden of AF. Asymptomatic atrial tachyarrhythmias,
being associated with increased risk of stroke, have important prognostic
implications, and their detection could guide decision-making about antithrombotic
prophylaxis. Pacing mode and pacing algorithms can influence the occurrence of AF
and atrial tachyarrhythmias. In DDD/DDDR pacing mode, reduction of unnecessary
right ventricular pacing positively affects the occurrence and evolution of AF, but
patients with a history of atrial tachyarrhythmias maintain an increased risk of
arrhythmic events. In the MINERVA study, the use of algorithms that act in the
atrium for preventive pacing and atrial antitachycardia pacing while minimizing
right ventricular pacing was beneficial in patients with SND and previous atrial
tachyarrhythmias, and was associated with a significant reduction in evolution to
permanent AF. New information available on therapies delivered at the atrial level
by implanted devices suggests clinical advantages that could improve current
guidelines for the management of AF and atrial tachyarrhythmias.
AD - Institute of Cardiology, Department of Experimental, Diagnostic and Specialty
Medicine, University of Bologna, S. Orsola-Malpighi University Hospital, Via
Massarenti 9, 40138 Bologna, Italy.
Institute of Internal Medicine and Cardiology, University of Florence, Viale
Morgagni 85, 50134 Florence, Italy.
AN - 25781413
AU - Boriani, G.
AU - Padeletti, L.
DA - Jun
DO - 10.1038/nrcardio.2015.30
DP - NLM
ET - 2015/03/18
IS - 6
J2 - Nature reviews. Cardiology
KW - Atrial Fibrillation/*diagnosis/etiology/*therapy
Bradycardia/*complications
Cardiac Pacing, Artificial/methods
Humans
Sick Sinus Syndrome/complications/therapy
LA - eng
N1 - 1759-5010
Boriani, Giuseppe
Padeletti, Luigi
Journal Article
Review
England
Nat Rev Cardiol. 2015 Jun;12(6):337-49. doi: 10.1038/nrcardio.2015.30. Epub 2015
Mar 17.
PY - 2015
SN - 1759-5002
SP - 337-49
ST - Management of atrial fibrillation in bradyarrhythmias
T2 - Nat Rev Cardiol
TI - Management of atrial fibrillation in bradyarrhythmias
VL - 12
ID - 2373
ER -
TY - JOUR
AB - AIM: to determine risk factors of early cardiovascular complications after
beating-heart coronary artery bypass grafting (CABG) in patients with ischemic
coronary disease (IHD) and type two diabetes (D2). MATERIALS AND METHODS: We
included into this study 188 patients (mean age 59 years, 85.1% men) with IHD and
D2 who underwent off-pump CABG. The following cardiovascular complications (CVC)
registered within 7 days after surgery were analyzed: myocardial infarction (MI),
stroke/transient ischemic attack (S/TIA), atrial fibrillation (AF). The control
group of patients without CVC was formed by case-control method. In the study
groups we compared IHD severity, coronary angiography, brachiocephalic and
peripheral arteries duplex ultrasonography data, blood pressure level, glomerular
filtration rate, EuroSCORE II risk, preoperative glycemic parameters and
hypoglycemic therapy, as well as CABG volume and severity. Factors associated with
postoperative CVC were determined by multiple stepwise logistic regression. RESULTS
AND CONCLUSIONS: CVC were registered in 47 patients (MI - in 18, S/TIA - in 2, AF -
in 27). As compared with the control group patients with CVC had higher Canadian
Cardiovascular Society angina class and EuroSCORE II risk, lower left ventricular
ejection fraction and glomerular filtration rate; they more frequently had left
main coronary artery involvement, total coronary artery occlusions, carotid and
peripheral artery disease. Group of patients with CVC had higher levels of
glycosylated hemoglobin, serum glucose and its diurnal variability, as well as
higher proportion of patients switched preoperatively from oral hypoglycemic agents
to rapid-acting insulin. According to logistic regression most informative
predictors of CVC were peripheral artery disease (odds ratio [OR] 3.4, 95%
confidence interval [CI] 1.7-7.1), diurnal serum glucose variability on admission
day (OR 13.2, 95% CI 5.9-30.0 per 0.1 mmol/l) and the day before surgery (OR 1.3,
95%CI 1.2-2.4 per 0.1 mmol/l), and switching from oral hypoglycemic agents to
insulin (OR 2.5, 95%CI 1.2-5.5).
AD - Irkutsk Regional Clinical Hospital, Irkutsk, Russia.
Irkutsk State Medical Academy of Continuing Education, Irkutsk, Russia.
AN - 28762929
AU - Borodashkina, S. Y.
AU - Protasov, K. V.
AU - Podkamennyi, V. A.
DA - Mar
DP - NLM
ET - 2017/08/02
IS - 3
J2 - Kardiologiia
KW - Atrial Fibrillation/etiology
Canada
Coronary Angiography
Coronary Artery Bypass, Off-Pump/*adverse effects
Coronary Artery Disease/complications/*therapy
Humans
Male
Middle Aged
*Postoperative Complications
Risk Factors
Stroke/etiology
Cabg
cardiovascular complications
diabetes
ischemic heart disease
LA - rus
N1 - Borodashkina, S Y
Protasov, K V
Podkamennyi, V A
Journal Article
Russia (Federation)
Kardiologiia. 2017 Mar;57(3):5-9.
PY - 2017
SN - 0022-9040 (Print)
0022-9040
SP - 5-9
ST - [Risk Factors of Cardiovascular Complications After Beating-Heart Coronary
Artery Bypass Grafting in Patients With Type Two Diabetes]
T2 - Kardiologiia
TI - [Risk Factors of Cardiovascular Complications After Beating-Heart Coronary
Artery Bypass Grafting in Patients With Type Two Diabetes]
VL - 57
ID - 2528
ER -
TY - JOUR
AB - BACKGROUND: We aimed to describe the current management of patients with
atrial fibrillation (AF) by cardiologists, and to identify predicting factors for a
stable disease course. METHODS: 2753 consecutive patients with ECG-confirmed AF in
the previous 12 months were documented in a 1-year observational (non-
interventional) study from 616 centers. Stable disease was defined as having
neither AF related intervention nor change in antiarrhythmic therapy in the
previous 12 months. Stepwise selection of parameters for multivariate regression
was used to identify factors for stable AF. RESULTS: At baseline, paroxysmal AF was
reported in 33.5%, persistent in 26.7%, and permanent in 39.7%; rate control alone
was the prevailing antiarrhythmic strategy (64.2%). Drugs for thromboembolic
prevention were administered in 93.8%, with a clear predominance of oral
anticoagulants (OAC), alone or in combination with antiplatelet drugs. Electrical
or pharmacological conversions were reported in 23.6%. A total of 96 (3.5%)
patients in the total cohort experienced stroke, 72 patients (2.6%) TIA, and 24
(0.9%) arterial embolism. 26% were hospitalized during follow-up (0.4 events per
patient), and 9.4% developed incident heart failure (42% prevalence at follow-up).
The rate of stable patients was 43.4%. In the multivariate model male gender,
history of stroke, and permanent (vs. persistent) AF were associated with stable
disease. Conversely, the factors chronic heart failure, impaired left ventricular
function, rhythm-control (vs. other), OAC and antiplatelet therapy were
significantly correlated with unstable disease. CONCLUSIONS: The relatively low
proportion of stable patients and in particular, the high hospitalization and
stroke rate indicate difficulties in everyday management of patients with AF.
AD - Kardiologische Praxis Asperger Str, Ludwigsburg, Germany. ralph.bosch@kardio-
praxis-lb.de
AN - 22475841
AU - Bosch, R. F.
AU - Kirch, W.
AU - Theuer, J. D.
AU - Pittrow, D.
AU - Kohlhaußen, A.
AU - Willich, S. N.
AU - Bonnemeier, H.
DA - Aug 10
DO - 10.1016/j.ijcard.2012.03.053
DP - NLM
ET - 2012/04/06
IS - 3
KW - Aged
Aged, 80 and over
Atrial Fibrillation/*diagnosis/epidemiology/*therapy
Cohort Studies
Disease Management
Female
Follow-Up Studies
Hospitalization/*trends
Humans
Male
Middle Aged
Prospective Studies
Risk Factors
Treatment Outcome
Atrial fibrillation
Hospitalization
Long-term
Management
Predictors
Thromboembolic prevention, stroke
LA - eng
N1 - 1874-1754
Bosch, Ralph F
Kirch, Wilhelm
Theuer, Juergen-Detlef
Pittrow, David
Kohlhaußen, Annette
Willich, Stefan N
Bonnemeier, Hendrik
Journal Article
Multicenter Study
Observational Study
Netherlands
Int J Cardiol. 2013 Aug 10;167(3):750-6. doi: 10.1016/j.ijcard.2012.03.053. Epub
2012 Apr 3.
PY - 2013
SN - 0167-5273
SP - 750-6
ST - Atrial fibrillation management, outcomes and predictors of stable disease in
daily practice: prospective non-interventional study
T2 - Int J Cardiol
TI - Atrial fibrillation management, outcomes and predictors of stable disease in
daily practice: prospective non-interventional study
VL - 167
ID - 2882
ER -
TY - JOUR
AB - BACKGROUND: It is current opinion that concealed and manifest accessory
pathways (APs) are indistinguishable with respect to their location and
contribution to orthodromic reciprocating tachycardias. The aim of this study was
to compare clinical and electrophysiological characteristics of two groups of
patients. METHODS: Between January 1999 and June 2000, 42 consecutive patients
underwent radiofrequency catheter ablation for paroxysmal atrioventricular
reciprocating tachycardia attributable to a concealed AP. Their clinical and
electrophysiological characteristics were compared with a group of 48 consecutive
patients with manifest AP and supraventricular tachyarrhythmias. RESULTS: There
were no differences regarding gender, the prevalence of heart disease and the age
of onset of symptomatic tachycardias between the two groups. Compared to those with
a manifest AP, the patients presenting with a tachyarrhythmia due to a concealed AP
were older (48 +/- 15 vs 40 +/- 16 years, p < 0.05) and had a longer history of
tachyarrhythmias (22 +/- 16 vs 13 +/- 13 years, p < 0.05). Atrial fibrillation was
more frequent in patients with a manifest AP than in patients with a concealed AP
(50 vs 9.5% respectively, p = 0.02). Atrioventricular reciprocating tachycardia was
a cause of more hospitalizations (76 vs 35%, p = 0.01) and episodes of pre-syncope
(47 vs 22%, p < 0.05) in the group of patients with a concealed AP. The anatomical
site of concealed and manifest APs was significantly different: concealed APs were
more frequently localized in the left side (93% left, 7% right), while manifest APs
were seen in the left side in 64% of cases, in the right side in 29% and in the
posteroseptal left + right region in 7% of cases. The retrograde
electrophysiological properties and the inducibility of other types of reentrant
arrhythmias were similar. Catheter ablation was similarly successful regardless of
whether the AP was concealed or manifest, the rates of success being 91 and 88%
respectively at the first attempt and with a similar number of energy applications
(7 +/- 7 vs 10 +/- 9, p = NS). At a second attempt, the procedure was successful in
100 and 98% of cases respectively. Periprocedural complications occurred in 5% of
patients with a concealed (1 ventricular fibrillation, 1 cerebral transient
ischemic attack) and in 8% of patients with a manifest AP (2 pericardial effusion,
1 transient atrioventricular block, 1 anginal attack with spontaneous recovery) (p
= NS). Complications occurred only for left-sided APs and were independent of the
approach (transseptal or retrograde). Relapse of AP conduction was more frequent in
the group of patients with a manifest than in those with a concealed AP (12 vs 5%),
though not significantly. There were no late complications. CONCLUSIONS: Those
patients presenting with a tachyarrhythmia due to a concealed AP, compared to those
with a manifest AP, were older and had a longer history of tachyarrhythmia. Atrial
fibrillation was more frequent in patients with manifest AP. Atrioventricular
reciprocating tachycardia episodes were longer-lasting and caused more
hospitalizations and more frequently pre-syncope in the group of patients with a
concealed AP. Almost all concealed APs were localized in the left side. The
retrograde electrophysiological properties were similar. The results of
radiofrequency catheter ablation were comparable in both groups.
AD - Unità Operativa di Cardiologia Interventistica, Azienda Ospedaliera S. Maria
Nuova, Via Risorgimento, 80 42100, Reggio Emilia. bottoni.nicola@asmn.re.it
AN - 11582721
AU - Bottoni, N.
AU - Donateo, P.
AU - Tomasi, C.
AU - Lolli, G.
AU - Oddone, D.
AU - Croci, F.
AU - Menozzi, C.
AU - Brignole, M.
DA - Aug
DP - NLM
ET - 2001/10/05
IS - 8
J2 - Italian heart journal. Supplement : official journal of the Italian
Federation of Cardiology
KW - Adult
Atrial Fibrillation/diagnosis/*physiopathology/surgery
Catheter Ablation
Electrophysiology
Female
Humans
Male
Middle Aged
Tachycardia, Supraventricular/diagnosis/*physiopathology/surgery
Wolff-Parkinson-White Syndrome/diagnosis/*physiopathology/surgery
LA - ita
N1 - Bottoni, N
Donateo, P
Tomasi, C
Lolli, G
Oddone, D
Croci, F
Menozzi, C
Brignole, M
Comparative Study
English Abstract
Journal Article
Italy
Ital Heart J Suppl. 2001 Aug;2(8):888-93.
OP - Confronto delle caratteristiche cliniche ed elettrofisiologiche dei pazienti
con via accessoria atrioventricolare occulta e manifesta.
PY - 2001
SN - 1129-4728 (Print)
1129-4728
SP - 888-93
ST - [Comparison of clinical and electrophysiologic characteristics of patients
with occult and manifest atrioventricular accessory pathway]
T2 - Ital Heart J Suppl
TI - [Comparison of clinical and electrophysiologic characteristics of patients
with occult and manifest atrioventricular accessory pathway]
VL - 2
ID - 2824
ER -
TY - JOUR
AB - We describe the extraction of a pacing lead via the femoral artery 5 months
after it was inadvertently introduced through the right subclavian artery and
positioned in the left ventricle. The lead was dislocated from the myocardium by
traction from the subpectoral area and subsequently removed with a retriever
inserted through the femoral artery in order to minimize the risk of cerebral
embolization and bleeding at the entry site. Bleeding was controlled at the
subclavian artery entry site by temporary inflation of a balloon catheter inserted
through the brachial artery, and at the insertion site of the retriever in the
femoral artery with a closure device.
AD - Department of Cardiology, Catharina Hospital, Eindhoven, the Netherlands.
f.bracke@skynet.be
AN - 12914636
AU - Bracke, F.
AU - Meijer, A.
DA - Jul
DO - 10.1046/j.1460-9592.2003.t01-1-00225.x
DP - NLM
ET - 2003/08/14
IS - 7 Pt 1
KW - Catheterization, Peripheral
Femoral Artery
Heart Block/therapy
Humans
Male
*Medical Errors
Middle Aged
Radiography, Interventional
*Subclavian Artery/diagnostic imaging
LA - eng
N1 - Bracke, Frank
Meijer, Albert
Case Reports
Journal Article
United States
Pacing Clin Electrophysiol. 2003 Jul;26(7 Pt 1):1544-7. doi: 10.1046/j.1460-
9592.2003.t01-1-00225.x.
PY - 2003
SN - 0147-8389 (Print)
0147-8389
SP - 1544-7
ST - Lead extraction via the femoral artery of a left ventricular pacing lead
inserted in the subclavian artery
TI - Lead extraction via the femoral artery of a left ventricular pacing lead
inserted in the subclavian artery
VL - 26
ID - 2961
ER -
TY - JOUR
AB - BACKGROUND: Atrial fibrillation (AF) is increasingly prevalent in elderly
patients and adversely affects clinical outcomes after coronary artery bypass
grafting, non-cardiac surgery or myocardial infarction. Aim of the present analysis
was to investigate the prognostic impact of AF in patients undergoing drug eluting
stent (DES) implantation during a 1-year follow-up. PATIENTS AND METHODS: 5,772
consecutive patients undergoing percutaneous coronary intervention were enrolled
into the German Drug Eluting Stent Registry (DES.DE) and were followed for 12
months. Of these 455 had AF and 5,317 in sinus rhythm served as controls.
Univariate and multivariate logistic regression analyses were used to determine the
risk of major adverse cardiac and cerebrovascular events (MACCE) and bleeding
complications. RESULTS: Patients with AF were older (71.3 ± 7.6 vs. 64.7 ± 10.5
years) and had a higher prevalence of diabetes, hypertension, renal insufficiency
as well as more prior bypass surgery, stroke and peripheral arterial disease.
Cardiogenic shock (2.9 vs. 1.4 %; p < 0.05), left ventricular ejection fraction ≤40
% (21.0 vs. 11.4 %; p < 0.0001) and triple vessel disease (44.4 vs. 37.9 %; p <
0.01) were more frequent in patients with AF than in controls. MACCE (OR 2.08, 95 %
CI 1.56-2.77), total mortality (OR 3.27, 95 % CI 2.32-4.62) and non-fatal stroke
(OR 2.03, 95 % CI 1.03-4.00) as well as bleeding complications (OR 1.88, 95 % CI
1.13-3.12) during the 1-year follow-up were more frequent in patients with AF
(univariate analysis). In multivariate analyses adjusting for covariates determined
to be relevant at baseline, the risk for total mortality remained elevated (OR
1.63, 95 % CI 1.05-2.52). CONCLUSIONS: AF is an important predictor of long-term
mortality in patients undergoing DES implantation.
AD - Institut für Pharmakologie und präventive Medizin, Mahlow, Germany.
AN - 23291664
AU - Bramlage, P.
AU - Cuneo, A.
AU - Zeymer, U.
AU - Hochadel, M.
AU - Richardt, G.
AU - Silber, S.
AU - Senges, J.
AU - Nienaber, C. A.
AU - Tebbe, U.
AU - Kuck, K. H.
DA - Apr
DO - 10.1007/s00392-012-0533-2
DP - NLM
ET - 2013/01/08
IS - 4
J2 - Clinical research in cardiology : official journal of the German Cardiac
Society
KW - Age Factors
Aged
Atrial Fibrillation/mortality/*surgery
Cardiovascular Diseases/epidemiology/etiology
*Drug-Eluting Stents
Follow-Up Studies
Germany
Hemorrhage/epidemiology/etiology
Humans
Logistic Models
Middle Aged
Percutaneous Coronary Intervention/*methods
Prognosis
Registries
Time Factors
LA - eng
N1 - 1861-0692
Bramlage, Peter
Cuneo, Alessandro
Zeymer, Uwe
Hochadel, Matthias
Richardt, Gert
Silber, Sigmund
Senges, Jochen
Nienaber, Christoph A
Tebbe, Ulrich
Kuck, Karl-Heinz
Journal Article
Germany
Clin Res Cardiol. 2013 Apr;102(4):289-97. doi: 10.1007/s00392-012-0533-2. Epub 2013
Jan 5.
PY - 2013
SN - 1861-0684
SP - 289-97
ST - Prognosis of patients with atrial fibrillation undergoing percutaneous
coronary intervention receiving drug eluting stents
T2 - Clin Res Cardiol
TI - Prognosis of patients with atrial fibrillation undergoing percutaneous
coronary intervention receiving drug eluting stents
VL - 102
ID - 2647
ER -
TY - JOUR
AB - Cardiac disease is common in patients with cerebrovascular disease (CVD) and
cerebral lesions as such may influence cardiac activity and rhythm. To study the
indication for continuous ECG surveillance of patients with CVD, 100 consecutive
patients admitted to a medical stroke unit were investigated with 24-hour Holter
recordings. The patients' mean age was 73 years and 70% of them had a history of
heart disease. Twenty-three patients had chronic atrial fibrillation and 55% of the
remainder showed ventricular ectopic activity. Serious ventricular arrhythmias were
comparatively rare and mainly seen in association with signs of congestive heart
failure and acute myocardial infarction. A prolonged Q-T interval was registered in
two-thirds of the patients but there was no significant association between this
finding and ventricular ectopic activity. Close observation for cardiac
complications is important in patients with CVD and continuous ECG surveillance is
indicated in selected high-risk patients.
AN - 443083
AU - Britton, M.
AU - de Faire, U.
AU - Helmers, C.
AU - Miah, K.
AU - Ryding, C.
AU - Wester, P. O.
DO - 10.1111/j.0954-6820.1979.tb06076.x
DP - NLM
ET - 1979/01/01
IS - 5
J2 - Acta medica Scandinavica
KW - Aged
Angina Pectoris/complications
Arrhythmias, Cardiac/*complications/diagnosis/mortality
Cerebrovascular Disorders/*complications/diagnosis/mortality
Electrocardiography
Humans
LA - eng
N1 - Britton, M
de Faire, U
Helmers, C
Miah, K
Ryding, C
Wester, P O
Journal Article
Sweden
Acta Med Scand. 1979;205(5):425-8. doi: 10.1111/j.0954-6820.1979.tb06076.x.
PY - 1979
SN - 0001-6101 (Print)
0001-6101
SP - 425-8
ST - Arrhythmias in patients with acute cerebrovascular disease
T2 - Acta Med Scand
TI - Arrhythmias in patients with acute cerebrovascular disease
VL - 205
ID - 2790
ER -
TY - JOUR
AB - Our studies of the brain microvascular system have focused on some aspects
not commonly studied by other research groups because we use some techniques not
often used by others. Our observations tend to add new details to the pathological
picture rather than contradict the mainstream findings. We use large, thick
celloidin sections which provide a three dimensional view of vascular networks, and
alkaline phosphatase (AP) staining which allows one to differentiate between
afferent and efferent vessels. We found millions of lipid microemboli in the brains
of patients after cardiac surgery, and concluded that they caused vascular dementia
in many patients. We previously proposed an animal model of vascular dementia using
brain irradiation, which induces capillary loss. Lipid emboli might also be used to
create an animal model of vascular dementia. The deep white matter is vulnerable to
chronic hypoperfusion because the blood vessels supplying this region arise from
the border-zone and have the longest course of all vessels penetrating the
cerebrum. In cases with leukoaraiosis (LA), we found periventricular venous
collagenosis (PVC), resulting in stenosis. Thirteen of 20 subjects older than 60
years had PVC, and 10 of 13 subjects with severe PVC had LA. Vascular stenosis
might induce chronic ischemia and/or edema in the deep white matter, leading to LA.
We suggest three mechanisms for a possible genetic predisposition to PVC: i) a
predisposition to excessive venous collagenosis; ii) an indirect effect that causes
chronic periventricular ischemia with a reactive over-production of collagen; and
iii) mechanical damage to small vessels due to increased pulsatile motion. We found
tortuous arterioles supplying the deep white matter beginning at about age 50. We
also found a trend toward an increase in tortuosity in LA. If tortuosity is a
factor in LA, it is probably significant in only a subset of cases. String vessels,
remnants of capillaries, occur commonly in the brain, and are increased in
ischemia, AD, and irradiation. Capillary injury or shutdown of blood flow can lead
to capillary loss and string vessel formation. We found string vessels in brains
from preterm babies to the very old. They seem to disappear after some months or
years. We found an early loss of capillaries in LA, followed in a few years by the
disappearance of string vessels. LA lesions do not progress to cortical cavitating
lesions. Our findings raise three questions. 1. Why is the capillary loss arrested
before infarction? 2. Why is there a floor below which the vascular density will
not fall? 3. Why does the process which initiates string vessels shut down? We
explain the vascular changes in LA as follows. LA induces apoptosis with loss of
oligodendrocytes. Capillaries and neuropil are lost. Increased oxygen extraction
from the blood in the deep white matter in LA implies that there are too many cells
for the remaining capillaries. Thus, the capillaries appear to die first. But why
do they stop dying? Perhaps a minimum number of capillaries are needed to transport
the arterial blood to the venous system. Once the capillaries stop dying, no more
string vessels are formed, and the string vessels gradually disappear.
AD - Department of Radiology, Wake Forest University School of Medicine, Medical
Center Boulevard, Winston-Salem, NC 27157, USA. wibrown@wfubmc.edu
AN - 19268311
AU - Brown, W. R.
AU - Moody, D. M.
AU - Thore, C. R.
AU - Anstrom, J. A.
AU - Challa, V. R.
C2 - PMC2713367
C6 - NIHMS97441
DA - Aug 15
DO - 10.1016/j.jns.2009.02.328
DP - NLM
ET - 2009/03/10
IS - 1-2
KW - Animals
Brain/*blood supply/pathology/*physiopathology
Capillaries/pathology/physiopathology
Cardiac Surgical Procedures/adverse effects
Cerebrovascular Disorders/*pathology/physiopathology
Dementia/etiology/*pathology/physiopathology
Dementia, Vascular/etiology/pathology/physiopathology
Disease Models, Animal
Humans
Microvessels/*pathology/physiopathology
Nerve Fibers, Myelinated/*pathology
Veins/pathology/physiopathology
LA - eng
N1 - 1878-5883
Brown, William R
Moody, Dixon M
Thore, Clara R
Anstrom, John A
Challa, Venkata R
R01 NS036780-05/NS/NINDS NIH HHS/United States
R01 CA113321-04/CA/NCI NIH HHS/United States
CA113321/CA/NCI NIH HHS/United States
NS 36780/NS/NINDS NIH HHS/United States
NS20618/NS/NINDS NIH HHS/United States
R01 NS020618/NS/NINDS NIH HHS/United States
R01 CA113321/CA/NCI NIH HHS/United States
Journal Article
J Neurol Sci. 2009 Aug 15;283(1-2):28-31. doi: 10.1016/j.jns.2009.02.328. Epub 2009
Mar 5.
PY - 2009
SN - 0022-510X (Print)
0022-510x
SP - 28-31
ST - Microvascular changes in the white mater in dementia
T2 - J Neurol Sci
TI - Microvascular changes in the white mater in dementia
VL - 283
ID - 3067
ER -
TY - JOUR
AB - This study aimed to investigate different echocardiographic parameters for
predicting atrial fibrillation (AF) in patients with transient ischemic attack
(TIA). Echocardiography was performed in 110 patients (median age 65.8 years, 53%
males) with TIA and no history of stroke or AF. All patients underwent monitoring
with ECG and 72 h Holter-monitoring, and if no AF was found, an insertable cardiac
monitor (ICM) was implanted and patients were followed for a median of 2.2 years.
AF was found in 14 patients: five with Holter-monitoring and nine with ICM. AF
patients had significantly larger left atrial (LA) volumes indexes compared to
patients without AF (26.7 vs. 33.7 ml/m(2), P = 0.03 for 2D images and 26.5 vs.
33.5 ml/m(2), P = 0.0008 for 3D images). Patients with AF also had depressed LA
function assessed with LA emptying fraction measured with 2D echocardiography (46.3
vs. 57.3%, P = 0.005 for patients with and without AF, respectively). Patients with
AF also had depressed left ventricular (LV) function compared to patients without
AF. LV ejection fraction was 55 versus 61%, P = 0.04 in patients with and without
AF, respectively. LV global longitudinal strain (absolute value) was 16.7 in
patients with AF compared to 21.2 in patients without AF (P = 0.001).
Echocardiographic measurements of LA and LV size and function can noninvasively
predict AF in patients with TIA and could potentially be used to guide AF
monitoring strategy.
AD - Department of Cardiology, Odense University Hospital, Sdr. Boulevard 29,
5000, Odense C, Odense, Denmark. KennethBruunPedersen@gmail.com.
Department of Neurology, Odense University Hospital, Odense, Denmark.
Department of Cardiology, Odense University Hospital, Sdr. Boulevard 29, 5000,
Odense C, Odense, Denmark.
AN - 30923993
AU - Bruun Pedersen, K.
AU - Madsen, C.
AU - Sandgaard, N. C. F.
AU - Hey, T. M.
AU - Diederichsen, A. C. P.
AU - Bak, S.
AU - Brandes, A.
DA - Jul
DO - 10.1007/s10554-019-01586-w
DP - NLM
ET - 2019/03/30
IS - 7
J2 - The international journal of cardiovascular imaging
KW - Adolescent
Adult
Aged
Aged, 80 and over
Atrial Fibrillation/*diagnostic imaging/etiology/physiopathology
*Atrial Function, Left
*Echocardiography, Doppler
Female
Heart Ventricles/*diagnostic imaging/physiopathology
Humans
Ischemic Attack, Transient/*complications/diagnosis/physiopathology
Male
Middle Aged
Prognosis
Prospective Studies
Risk Factors
Stroke Volume
Time Factors
*Ventricular Function, Left
Young Adult
Atrial fibrillation
Echocardiography
Global longitudinal strain
Left atrial volume
Transient ischemic attack
LA - eng
N1 - 1875-8312
Bruun Pedersen, Kenneth
Orcid: 0000-0002-4083-147x
Madsen, Charlotte
Sandgaard, Niels Christian Foldager
Hey, Thomas Morris
Diederichsen, Axel Cosmus Pyndt
Bak, Søren
Brandes, Axel
Journal Article
United States
Int J Cardiovasc Imaging. 2019 Jul;35(7):1277-1286. doi: 10.1007/s10554-019-01586-
w. Epub 2019 Mar 28.
PY - 2019
SN - 1569-5794
SP - 1277-1286
ST - Left atrial volume index and left ventricular global longitudinal strain
predict new-onset atrial fibrillation in patients with transient ischemic attack
T2 - Int J Cardiovasc Imaging
TI - Left atrial volume index and left ventricular global longitudinal strain
predict new-onset atrial fibrillation in patients with transient ischemic attack
VL - 35
ID - 2305
ER -
TY - JOUR
AB - BACKGROUND: Despite the increasing number of cardiac implantable electronic
devices (CIED) procedures worldwide, no guideline assessed postoperative
mobilization protocols. Lacking evidences in literature, many centers require 24-
hour immobilization and bed rest to minimize the risk of pacing lead (PL)
dislodgement. Prolonged immobilization may futilely delay discharge, induce pain
and reduced joint mobility especially in elderly patients. We examined whether
early mobilization at 3-h after CIED surgery would result in higher complication
rates, compared with standard 24-hour immobilization. METHODS: Consecutive patients
undergoing CIED implantation were randomized to early (3-h) mobilization protocol
with an arm sling support (E-motion group, EMG) vs. standard (24-h) immobilization
(control group, CG). The primary end-point was 24-month PL dislodgement. Secondary
safety end-point was any major intra-procedural complication (cardiac perforation,
pericardial tamponade, valve damage, haemothorax, pneumothorax, myocardial
infarction, peripheral embolus, TIA/stroke or death). RESULTS: Among 200 enrolled
patients, 86% underwent pacemaker implantation (28% single-chamber, 72% dual-
chamber device), 14% underwent ICD implantation (75% single-chamber, 25% dual-
chamber device). PL fixation was mostly passive (97% atrial PL, 88% ventricular
PL), without differences between EMG and CG (p = 0.99). No differences were
observed in the incidence of 24-month PL dislodgement (3% in the EMG vs. 4% in the
CG, p = 0.99). No major intra-procedural complications were observed. CONCLUSIONS:
Early mobilization at 3-h following CIED surgery is safe and feasible compared with
standard immobilization and is not associated with an increased risk of intra-
procedural complications or 24-month lead dislodgment. So, same-day implantation
and discharge might be possible.
AD - Division of Cardiology, A.O.U. Città della Salute e della Scienza di Torino-
Molinette, Department of Medical Sciences, University of Turin, Turin, Italy.
Division of Cardiology, A.O.U. Città della Salute e della Scienza di Torino-
Molinette, Department of Medical Sciences, University of Turin, Turin, Italy.
Electronic address: alessandro.andreis@unito.it.
Department of Surgical Sciences, University of Turin, Turin, Italy.
AN - 31031076
AU - Budano, C.
AU - Garrone, P.
AU - Castagno, D.
AU - Bissolino, A.
AU - Andreis, A.
AU - Bertolo, L.
AU - Mazzini, D.
AU - Bergamasco, L.
AU - Marra, S.
AU - Gaita, F.
DA - Aug 1
DO - 10.1016/j.ijcard.2019.04.020
DP - NLM
ET - 2019/04/30
KW - Aged
Arrhythmias, Cardiac/*surgery
Female
Follow-Up Studies
Humans
Immobilization/*methods
Male
Patient Discharge/*trends
Postoperative Complications/*prevention & control
Prospective Studies
Risk Factors
Treatment Outcome
*Cardiac implantable electronic device
*Implantable-cardioverter-defibrillator
*Pacemaker
LA - eng
N1 - 1874-1754
Budano, Carlo
Garrone, Paolo
Castagno, Davide
Bissolino, Arianna
Andreis, Alessandro
Bertolo, Laura
Mazzini, Diana
Bergamasco, Laura
Marra, Sebastiano
Gaita, Fiorenzo
Journal Article
Netherlands
Int J Cardiol. 2019 Aug 1;288:82-86. doi: 10.1016/j.ijcard.2019.04.020. Epub 2019
Apr 8.
PY - 2019
SN - 0167-5273
SP - 82-86
ST - Same-day CIED implantation and discharge: Is it possible? The E-MOTION trial
(Early MObilization after pacemaker implantaTION)
T2 - Int J Cardiol
TI - Same-day CIED implantation and discharge: Is it possible? The E-MOTION trial
(Early MObilization after pacemaker implantaTION)
VL - 288
ID - 2930
ER -
TY - JOUR
AB - BACKGROUND: Catheter ablation of atrial fibrillation (AF) is an established
therapy for symptomatic patients. The long-term efficacy and impact of catheter
ablation among patients with severe systolic heart failure (SHF) requires
additional study to understand if outcomes achieved at 1 year are maintained and
mechanisms of AF recurrence. METHODS: Three groups with SHF and 5 years of follow-
up were matched 1:4:4 by age (±5 years) and sex: AF ablation patients receiving
their first ablation (n = 267), AF patients that did not receive an ablation (n =
1,068), and SHF patient without AF (n = 1,068). SHF was based upon clinical
diagnosis and an ejection fraction (EF) ≤35%. Patients were followed for 5-year
primary outcomes of AF recurrence, heart failure, stroke, death, and cardiac
function. RESULTS: At 5 years, 60.7% of patients had clinical recurrence of AF.
Diabetes and a prior heart attack were significant predictors of long-term risk of
AF recurrence. Long-term mortality rates were 27%, 55%, 50%, in the AF ablation,
AF, and no AF groups, respectively (P < 0.0001), with the lower rates attributed to
lower cardiovascular mortality. At 5 years, there was no difference in EF, yet HF
hospitalizations were lower following AF ablation compared to patients with AF and
no ablation. Stroke rates at 5 years trended to be lower in the AF ablation group,
but the difference was not statistically significant. CONCLUSION: Recurrence rates
of AF in patients with SHF after ablation are common at 5 years with an anticipated
ongoing increase. Long-term AF-related comorbidities tended to be less in the AF
ablation group.
AD - Intermountain Heart Institute, Intermountain Medical Center, Murray, Utah,
USA.
AN - 25534572
AU - Bunch, T. J.
AU - May, H. T.
AU - Bair, T. L.
AU - Jacobs, V.
AU - Crandall, B. G.
AU - Cutler, M.
AU - Weiss, J. P.
AU - Mallender, C.
AU - Osborn, J. S.
AU - Anderson, J. L.
AU - Day, J. D.
DA - Apr
DO - 10.1111/jce.12602
DP - NLM
ET - 2014/12/24
IS - 4
J2 - Journal of cardiovascular electrophysiology
KW - Aged
Aged, 80 and over
Atrial Fibrillation/diagnosis/mortality/physiopathology/*surgery
*Catheter Ablation/adverse effects/mortality
Comorbidity
Disease Progression
Female
Heart Failure/mortality/physiopathology
Humans
Male
Middle Aged
Recovery of Function
Recurrence
Risk Factors
Stroke/mortality/physiopathology
Stroke Volume
*Systole
Time Factors
Treatment Outcome
Utah/epidemiology
Ventricular Dysfunction, Left/diagnosis/*epidemiology/mortality/physiopathology
atrial fibrillation
catheter ablation
heart failure
mortality
outcomes
stroke
LA - eng
N1 - 1540-8167
Bunch, T Jared
May, Heidi T
Bair, Tami L
Jacobs, Victoria
Crandall, Brian G
Cutler, Michael
Weiss, J Peter
Mallender, Charles
Osborn, Jeffrey S
Anderson, Jeffrey L
Day, John D
Journal Article
United States
J Cardiovasc Electrophysiol. 2015 Apr;26(4):363-370. doi: 10.1111/jce.12602. Epub
2015 Feb 11.
PY - 2015
SN - 1045-3873
SP - 363-370
ST - Five-year outcomes of catheter ablation in patients with atrial fibrillation
and left ventricular systolic dysfunction
T2 - J Cardiovasc Electrophysiol
TI - Five-year outcomes of catheter ablation in patients with atrial fibrillation
and left ventricular systolic dysfunction
VL - 26
ID - 2463
ER -
TY - JOUR
AB - BACKGROUND/OBJECTIVES: Acute pulmonary embolism (PE) can be a life-
threatening condition. Right ventricular function evaluated by echocardiography,
brain natriuretic peptide levels and several patterns on the electrocardiogram have
been utilized to guide treatment and prognosis. Case reports described heart rate
corrected QT (QTc) prolongation as an ECG finding associated with PE. However, the
prognostic value of QTc prolongation has not been studied. METHODS: Retrospective
chart review of 300 consecutive patients (mean age 60.3 ± 17.6 years; 40.7% men)
diagnosed with acute PE by computed tomography pulmonary angiography or ventilation
perfusion scan were studied. Patients were divided into two groups: a prolonged QTc
group with QTc >460 milliseconds (n=178) and a control group (n=122). We
retrospectively reviewed medical records, electrocardiography, echocardiography and
radiography results. Statistical analyses included unpaired t-test and Fisher's
exact test using Stata version12. RESULTS: The prolonged QTc group demonstrated
significantly increased right ventricular dilatation and systolic dysfunction.
Additionally, the duration of hospitalization and intensive care unit stay were
longer in the prolonged QTc group. Further, the prolonged QTc group had more
hypotensive episodes and received thrombolytic treatment more frequently. There was
no statistical difference in in-patient mortality rates (4.5% for the study group
and 4.2% for the control group, P=1). CONCLUSIONS: Prolonged QTc may prove a novel
predictor for evaluating prognosis in acute PE. Larger studies will need to confirm
this finding.
AN - 25638843
AU - Buppajarntham, S.
AU - Seetha Rammohan, H. R.
AU - Junpaparp, P.
AU - Figueredo, V. M.
DA - Oct
DO - 10.1080/ac.69.5.3044882
DP - NLM
ET - 2015/02/03
IS - 5
J2 - Acta cardiologica
KW - Acute Disease
Echocardiography
Electrocardiography
Female
Hospital Mortality
Humans
Length of Stay/statistics & numerical data
Long QT Syndrome/diagnosis/*physiopathology
Male
Middle Aged
Prognosis
Pulmonary Embolism/diagnosis/*physiopathology
LA - eng
N1 - Buppajarntham, Saranya
Seetha Rammohan, Harish Raj
Junpaparp, Parichart
Figueredo, Vincent M
Journal Article
England
Acta Cardiol. 2014 Oct;69(5):550-5. doi: 10.1080/ac.69.5.3044882.
PY - 2014
SN - 0001-5385 (Print)
0001-5385
SP - 550-5
ST - Prognostic value of prolonged QTc interval in patients with acute pulmonary
embolism
T2 - Acta Cardiol
TI - Prognostic value of prolonged QTc interval in patients with acute pulmonary
embolism
VL - 69
ID - 2973
ER -
TY - JOUR
AB - Atrial fibrillation (AF) presents disorganized activity of atrium with
irregular ventricular striking. It is observed in paroxysmal and persisting form.
Paroxysmal form is more risky for embolism (about 6 times). Aim of this research
was to determine frequency of atrial fibrillation as increased risk for
cerebrovascular insult (CVI). We conducted our research in general hospital Konjic
and all patients who were treated in the period 1998-1999 are included. The results
of the research are the following: 1. Total number of CVI patients was 126 what
compared with total number of hospitalized patients indicates increased prevalence
of 8.8% in relation to world parameters (2-5%). 2. 55.7% CVI patients had verified
persistent AF what also represents increased percentage compared to the world
parameters. 3. The following cardiovascular diseases are involved in the etiology
of AF where CVI was a result: *atherosclerosis of heart 84.9%, *coronary disease
15.6%, *heart malformations, 4.76%, *other diseases (hyperthyroidism 1.5%,
idiopathic AF). 4. Incidence of other risk factors at the patients with CVI and AF:
*hypertension 63.4%, *diabetes mellitus 23.8%, *smoking 9.5%, *hyperlipoproteinemia
5.5%, *2 and more risk factors 97.8%. 5. Patients with CVI and AF are more often
women and more than 60 years old. According to the results of this research, an
incidence of AF in CVI is lager in comparison to the world parameters. AF in
persisting form occurs mostly at arteriosclerosis of heart. Women more than 60
years old are the most jeopardized category. Concerning that CVI is in the first
place as a cause of invalidity and in the third place as a cause of death, AF as a
risk for CVI has important place in the prevention and treatment together with
other risk factors.
AD - Opsća bolnica Konjic.
AN - 11117034
AU - Buturović, N.
AU - Jusufbegović, A.
AU - Radulović, S.
AU - Mulić, S.
DP - NLM
ET - 2000/12/16
IS - 4
J2 - Medicinski arhiv
Bosnia and Herzegovina
Emergency Service, Hospital
Humans
Risk Factors
Stroke/*etiology
LA - hrv
N1 - Buturović, N
Jusufbegović, A
Radulović, S
Mulić, S
English Abstract
Journal Article
Bosnia and Herzegovina
Med Arh. 2000;54(4):237-8.
OP - Ucestalost fibrilacije atrija i cerebrovaskularnog inzulta u zbrinjavanju
pacijenata u urgentnom centru opće bolnice Konjic.
PY - 2000
SN - 0350-199x
SP - 237-8
ST - [Occurrence of atrial fibrillation and cerebrovascular insult in patients at
the Emergency Center of the General Hospital in Konjic]
T2 - Med Arh
TI - [Occurrence of atrial fibrillation and cerebrovascular insult in patients at
the Emergency Center of the General Hospital in Konjic]
VL - 54
ID - 2734
ER -
TY - JOUR
AB - The cohort of workers employed in a Swedish vinyl chloride/poly(vinyl
chloride) plant since its start in the early 1940's has been followed for mortality
and cancer morbidity patterns. Only 21 of the 771 persons could not be traced.
Difficulties in establishing exposure levels at different work areas in the past
makes an evaluation of dose-effect relationships impossible. A four- to fivefold
excess of pancreas/liver tumors was found, including two cases later classified as
angiosarcomas of the liver. The number of brain tumors and suicide do not deviate
significantly from expected. Cardiovascular and cerebrovascular diseases, on the
other hand, differ significantly from the expected. The discrepancies between
previous reports on VCM/PVC workers and this report are discussed. The possible
etiology of the cardiovascular deaths is also discussed.
AN - 1026402
AU - Byrén, D.
AU - Engholm, G.
AU - Englund, A.
AU - Westerholm, P.
C2 - PMC1475258
DA - Oct
DO - 10.1289/ehp.17-1475258
DP - NLM
ET - 1976/10/01
J2 - Environmental health perspectives
KW - Accidents, Occupational
*Chemical Industry
Humans
Mortality
Neoplasms/*epidemiology/mortality
Occupational Diseases/*epidemiology/mortality
*Polyvinyl Chloride
*Polyvinyls
Registries
Suicide/epidemiology
Sweden
Time Factors
Vascular Diseases/epidemiology/mortality
*Vinyl Chloride
*Vinyl Compounds
LA - eng
N1 - Byrén, D
Engholm, G
Englund, A
Westerholm, P
Journal Article
Environ Health Perspect. 1976 Oct;17:167-70. doi: 10.1289/ehp.17-1475258.
PY - 1976
SN - 0091-6765 (Print)
0091-6765
SP - 167-70
ST - Mortality and cancer morbidity in a group of Swedish VCM and PCV production
workers
T2 - Environ Health Perspect
TI - Mortality and cancer morbidity in a group of Swedish VCM and PCV production
workers
VL - 17
ID - 3128
ER -
TY - JOUR
AB - Cardiovascular magnetic resonance (CMR) imaging is being increasingly used to
help identify patients with cardiac sarcoidosis (CS). Whereas ventricular
arrhythmias have been well studied in this population, atrial arrhythmias have not
been thoroughly investigated. We sought to better characterize the arrhythmia
burden of a cohort of patients diagnosed with CS by CMR imaging. Patients with
biopsy-proven extracardiac sarcoidosis were referred to the University of Chicago
for evaluation of the presence of CS. CMR imaging was used to categorize the
patients into 2 groups; those with and those without late gadolinium enhancement
(LGE) for comparison of arrhythmic events. Arrhythmic evaluation included Holter
monitor, event recorder, electrophysiology testing, or implantable cardioverter-
defibrillator (ICD) interrogation; 192 consecutive patients were evaluated with CMR
imaging, 57 of whom did not have ambulatory monitoring results and thus were
excluded. LGE was present in 44 patients. Atrial arrhythmias were documented in 16
patients (36%) with myocardial LGE and in 11 patients (12%) without myocardial LGE
(p = 0.002). Ventricular arrhythmias were documented in 27% of patients with
myocardial LGE and 2.2% of LGE-negative patients (p = 0.00076). Of 26 LGE-positive
patients with ICDs, 8 (30.8%) received therapies, 3 (11.5%) of which were
inappropriate for atrial arrhythmias. In conclusion, atrial arrhythmias were
documented more frequently than ventricular arrhythmias in patients with
sarcoidosis with cardiac involvement and were 3 times more prevalent than in
patients with sarcoidosis without cardiac involvement. Risk-benefit assessment of
anticoagulation for primary prevention of stroke should be performed for patients
with CS. In patients receiving implantable defibrillators, programming to minimize
inappropriate ICD shocks for atrial arrhythmias must be considered.
AD - Department of Medicine, Division of Cardiology, Heart Rhythm Center,
University of Chicago, Chicago, Illinois.
Department of Medicine, University of Illinois Medical Center, Chicago, Illinois.
Department of Medicine, Division of Cardiology, Heart Rhythm Center, University of
Chicago, Chicago, Illinois. Electronic address: jfbeshai@gmail.com.
AN - 24731652
AU - Cain, M. A.
AU - Metzl, M. D.
AU - Patel, A. R.
AU - Addetia, K.
AU - Spencer, K. T.
AU - Sweiss, N. J.
AU - Beshai, J. F.
DA - May 1
DO - 10.1016/j.amjcard.2014.01.434
DP - NLM
ET - 2014/04/16
IS - 9
KW - Adult
Arrhythmias, Cardiac/*complications/physiopathology
Cardiomyopathies/complications/*diagnosis/drug therapy
Female
*Gadolinium
Humans
Magnetic Resonance Imaging/*methods
Male
Middle Aged
Risk Assessment
Sarcoidosis/complications/*diagnosis/drug therapy
LA - eng
N1 - 1879-1913
Cain, Matthew A
Metzl, Mark D
Patel, Amit R
Addetia, Karima
Spencer, Kirk T
Sweiss, Nadera J
Beshai, John F
Journal Article
United States
Am J Cardiol. 2014 May 1;113(9):1556-60. doi: 10.1016/j.amjcard.2014.01.434. Epub
2014 Feb 12.
PY - 2014
SN - 0002-9149
SP - 1556-60
ST - Cardiac sarcoidosis detected by late gadolinium enhancement and prevalence of
atrial arrhythmias
T2 - Am J Cardiol
TI - Cardiac sarcoidosis detected by late gadolinium enhancement and prevalence of
atrial arrhythmias
VL - 113
ID - 2338
ER -
TY - JOUR
AB - BACKGROUND: When a patient survives thrombolysis for acute myocardial
infarction, little information from large studies exists from which to estimate
prognosis during follow-up visits. METHODS AND RESULTS: Baseline, in-hospital, and
later survival data were collected from 41 021 patients enrolled in Global
Utilization of Streptokinase and TPA for Occluded Coronary Arteries, a randomized
trial of 4 thrombolytic-heparin regimens with standard aspirin and beta-blockade.
Cox proportional hazards models were developed to predict 1-year survival in 30-day
survivors (n=37 869) from baseline clinical and ECG factors and in-hospital
factors; a combined model then was developed (C-index 0.800). The model was
simplified into a nomogram to predict individual outcomes (C-index 0.754). Factors
reflecting demographics (advanced age, lighter weight), larger infarctions (higher
Killip class, lower blood pressure, faster heart rate, longer QRS duration),
cardiac risk (smoking, hypertension, prior cerebrovascular disease), and arrhythmia
were important predictors of death between 30 days and 1 year. Black race was
associated with a substantial increase in risk after considering other factors.
Revascularization was associated with reduced risk between 30 days and 1 year.
CONCLUSIONS: When evaluating a patient who has survived acute infarction treated
with thrombolysis, clinicians can estimate the likelihood of survival from factors
easily measured during admission. Although many risk factors clearly relate to age,
left ventricular dysfunction, or clinical instability, black race is an unexplained
risk factor requiring further examination.
AD - Duke Clinical Research Institute, Durham, NC, USA. calif001@mc.duke.edu
AN - 10811588
AU - Califf, R. M.
AU - Pieper, K. S.
AU - Lee, K. L.
AU - Van De Werf, F.
AU - Simes, R. J.
AU - Armstrong, P. W.
AU - Topol, E. J.
DA - May 16
DO - 10.1161/01.cir.101.19.2231
DP - NLM
ET - 2000/05/16
IS - 19
J2 - Circulation
KW - Aged
Coronary Disease/*drug therapy
Female
Humans
Male
Middle Aged
Myocardial Infarction/mortality/*therapy
Prognosis
Streptokinase/*therapeutic use
Survival Analysis
*Thrombolytic Therapy
Tissue Plasminogen Activator/*therapeutic use
LA - eng
N1 - 1524-4539
Califf, R M
Pieper, K S
Lee, K L
Van De Werf, F
Simes, R J
Armstrong, P W
Topol, E J
Clinical Trial
Journal Article
United States
Circulation. 2000 May 16;101(19):2231-8. doi: 10.1161/01.cir.101.19.2231.
PY - 2000
SN - 0009-7322
SP - 2231-8
ST - Prediction of 1-year survival after thrombolysis for acute myocardial
infarction in the global utilization of streptokinase and TPA for occluded coronary
arteries trial
T2 - Circulation
TI - Prediction of 1-year survival after thrombolysis for acute myocardial
infarction in the global utilization of streptokinase and TPA for occluded coronary
arteries trial
VL - 101
ID - 3132
ER -
TY - JOUR
AB - We presented examples of both supraventricular and ventricular rhythm
disorders which can occur in athletic individuals, even presidents. The vast
majority of rhythm problems we deal with in athletes are fortunately benign,
entities such as frequent atrial ectopic beats or VPBs. In each patient
encountered, we ask ourselves the five questions noted in the discussion pertaining
to symptomatology, anatomic source of the arrhythmia, presence or absence of
underlying cardiac disease, and precipitating factors. The most common more
sustained SVTs we see are AVNRT and atrial fibrillation. Atrial flutter is less
common. These are more of a nuisance to patients rather than a threat to their
lives, although rarely cerebral embolic events can occur. Therapy includes
avoidance of precipitating factors and, when necessary, a sequential trial of
available drugs, carefully documenting the response and watching closely for any
pro-arrhythmic events. We infrequently see NSVT in athletes, even triplets of VPBs
on exercise testing, and rarely see instances of sustained VT. The latter merits a
careful search for underlying cardiac disease and usually electrophysiology-guided
drug therapy. New techniques such as radiofrequency ablation of the dysrhythmic
focus may obviate the need for chronic drug therapy in selected cases.
AD - Cardiac Rehabilitation and the Internal Medicine Residency Program, Georgia
Baptist Medical Center, Atlanta 30312-1239.
AN - 1607846
AU - Cantwell, J. D.
AU - Lammert, S.
DA - Jun
DP - NLM
ET - 1992/06/01
IS - 6
J2 - Journal of the Medical Association of Georgia
KW - Adult
Arrhythmias, Cardiac/drug therapy/*etiology/physiopathology
Electrocardiography
Female
Humans
Male
Running/*injuries
LA - eng
N1 - Cantwell, J D
Lammert, S
Case Reports
Journal Article
United States
J Med Assoc Ga. 1992 Jun;81(6):311-5.
PY - 1992
SN - 0025-7028 (Print)
0025-7028
SP - 311-5
ST - Cardiac arrhythmias in presidents and other athletes
T2 - J Med Assoc Ga
TI - Cardiac arrhythmias in presidents and other athletes
VL - 81
ID - 2486
ER -
TY - JOUR
AB - OBJECTIVES: Preventing stroke after coronary artery bypass grafting (CABG)
remains a therapeutic goal, due in part to the lack of identifiable risk factors.
The aim of this study, accordingly, was to identify risk factors in CABG patients
with a previous history of stroke. METHODS: Patients with a history of stroke who
underwent CABG at Beijing An Zhen hospital from January 2007 to July 2010 were
selected (n = 430), and divided into two groups according to the occurrence of
postoperative stroke. Pre-operative and post-operative data were retrospectively
collected and analyzed by univariate and multivariate logistic regression analyses.
RESULTS: Thirty-two patients (7.4%) suffered post-operative stroke. Univariate
analysis identified several statistically significant risk factors in the post-
operative stroke group, including pre-surgical left ventricular ejection fractions
(LVEF) ≤50%, on-pump surgery, post-operative atrial fibrillation (AF), and
hypotension. Multivariable analysis identified 4 independent risk factors for
recurrent stroke: unstable angina (odds ratio (OR) = 2.95, 95% CI: 1.05-8.28), LVEF
≤50% (OR = 2.77, 95% CI: 1.23-6.27), AF (OR = 4.69, 95% CI: 1.89-11.63), and
hypotension (OR = 2.55, 95% CI: 1.07-6.04). CONCLUSION: Unstable angina, LVEF ≤50%,
post-operative AF, and post-operative hypotension are independent risk factors of
recurrent stroke in CABG patients with a previous history of stroke.
AD - Department of Anesthesiology, Cardiovascular Institute and Fuwai Hospital,
Chinese Academic Medical Science and Peking Union Medical College, Beijing, China.
AN - 22112676
AU - Cao, L.
AU - Li, Q.
AU - Bi, Q.
AU - Yu, Q. J.
C2 - PMC3253694
DA - Nov 23
DO - 10.1186/1749-8090-6-157
DP - NLM
ET - 2011/11/25
J2 - Journal of cardiothoracic surgery
KW - Atrial Fibrillation/*complications/epidemiology
China/epidemiology
Coronary Artery Bypass/*adverse effects
Female
Follow-Up Studies
Humans
Hypotension/*complications/epidemiology
Incidence
Male
Middle Aged
Myocardial Ischemia/*surgery
Recurrence
Risk Factors
LA - eng
N1 - 1749-8090
Cao, Li
Li, Qin
Bi, Qi
Yu, Qin-Jun
Comparative Study
Journal Article
J Cardiothorac Surg. 2011 Nov 23;6:157. doi: 10.1186/1749-8090-6-157.
PY - 2011
SN - 1749-8090
SP - 157
ST - Risk factors for recurrent stroke after coronary artery bypass grafting
T2 - J Cardiothorac Surg
TI - Risk factors for recurrent stroke after coronary artery bypass grafting
VL - 6
ID - 2526
ER -
TY - JOUR
AB - BACKGROUND AND PURPOSE: Chagasic cardiomyopathy is independently associated
with ischemic stroke in Chagas disease. American trypanosomiasis, Chagas disease
(CD), is a major public health problem in South America. We sought to evaluate
prevalence of vascular risk factors for stroke in patients with stroke caused by
CD. METHODS: Ninety-four consecutive CD stroke patients and 150 consecutive
nonchagasic stroke patients were studied. CD was confirmed when both
immunofluorescence and hemagglutination serology were positive. Data collected
included age, sex, vascular risk factors, diagnostic stroke subtype (TOAST
classification), and echocardiography findings. Fasting plasma levels of protein C,
protein S, antithrombin III, homocysteine, activated protein C resistance, IgG
anticardiolipin antibodies, lupus anticoagulant, and genetic tests for the factor V
Leiden and the C677T methylene tetrahydrofolate reductase gene mutation were
determined. RESULTS: CD patients had a mean age of 56.31 years compared with 61.59
years for non-CD stroke patients (P=0.0002). Cardioembolism occurred in 56.38% of
CD stroke patients compared with 9.33% in controls (P=0.000), whereas
atherothrombotic strokes occurred in 8.51% of CD strokes versus 20% in controls
(P=0.016), and small-vessel stroke in 9.57% of CD stroke patients versus 34.67% in
controls (P=0.000). Apical aneurysm (37.23% versus 0.67%; OR, 88.39), left
ventricular dilatation (23.4% versus 5.33%; OR, 5.42), mural thrombus (11.7 versus
2%; OR, 6.49) and abnormal electrocardiography (ECG) (66% versus 23.33%; OR, 2.87)
were significantly higher in the group of chagasic stroke patients. No statistical
differences were observed in thrombophilia between both groups. The significant
variables that predicted CD stroke patients on a stepwise logistical regression
model were apical aneurysm, cardiac insufficiency, ECG arrhythmia, female gender,
and hypertension. CONCLUSIONS: Chagasic cardiomyopathy is independently associated
with ischemic stroke, whereas hypercoagulable states do not appear to be major
contributors to the excess stroke risk seen in patients with CD.
AD - Department of Neurology, The Sarah Network of Hospitals of Rehabilitation,
Sarah Hospital, Brasilia DF, Brazil. javier@bsb.sarah.br
AN - 15845889
AU - Carod-Artal, F. J.
AU - Vargas, A. P.
AU - Horan, T. A.
AU - Nunes, L. G.
DA - May
DO - 10.1161/01.Str.0000163104.92943.50
DP - NLM
ET - 2005/04/23
IS - 5
J2 - Stroke
KW - Adult
Aged
Brain Ischemia/*etiology
Chagas Cardiomyopathy/*complications/diagnosis
Chagas Disease/complications/diagnosis
Electrocardiography
Female
Heart Diseases/complications/diagnosis/diagnostic imaging
Humans
Male
Middle Aged
Risk Factors
Stroke/diagnosis/*etiology
Thrombophilia/diagnosis
Ultrasonography
LA - eng
N1 - 1524-4628
Carod-Artal, Francisco Javier
Vargas, Antonio Pedro
Horan, Thomas Anthony
Nunes, Luiz Guillerme Nadal
Journal Article
United States
Stroke. 2005 May;36(5):965-70. doi: 10.1161/01.STR.0000163104.92943.50. Epub 2005
Apr 21.
PY - 2005
SN - 0039-2499
SP - 965-70
ST - Chagasic cardiomyopathy is independently associated with ischemic stroke in
Chagas disease
T2 - Stroke
TI - Chagasic cardiomyopathy is independently associated with ischemic stroke in
Chagas disease
VL - 36
ID - 2844
ER -
TY - JOUR
AB - In three cases of cardiac arrest in which resuscitation was successful, there
were striking similarities. The patients were men with anterior myocardial
infarction and the mode of cardiac arrest was ventricular fibrillation. Corrective
action was begun promptly after arrest occurred. In each case vasopressor agents
were required for three to five days after resuscitation before the cardiovascular
system was able to maintain a normal blood pressure without this aid. Convalescence
was satisfactory and each patient returned to his usual occupation. The procedure
that was used for cardiac resuscitation was based on artifical respiration (by any
of several methods) and artificial circulation by external cardiac compression to
provide a flow of oxygenated blood to the brain. Once this is established, time is
afforded to determine what other steps are needed.
AN - 14165871
AU - Casdorph, H. R.
C2 - PMC1515526
DA - Apr
DP - NLM
ET - 1964/04/01
IS - 4
J2 - California medicine
KW - *Calcium
*Calcium, Dietary
*Cardiovascular Diseases
*Chlorides
*Drug Therapy
*Electric Stimulation Therapy
*Epinephrine
*Heart Arrest
*Heart Massage
Humans
*Hypothermia
Male
*Metaraminol
*Myocardial Infarction
*Potassium
*Resuscitation
*Ventricular Fibrillation
*electrotherapy
*myocardial infarct
LA - eng
N1 - Casdorph, h r
Journal Article
Calif Med. 1964 Apr;100(4):248-51.
PY - 1964
SN - 0008-1264 (Print)
0008-1264
SP - 248-51
ST - HOSPITAL EXPERIENCE WITH CARDIAC RESUSCITATION
T2 - Calif Med
TI - HOSPITAL EXPERIENCE WITH CARDIAC RESUSCITATION
VL - 100
ID - 2984
ER -
TY - JOUR
AB - BACKGROUND AND PURPOSE: The CHADS(2) and CHA(2) DS(2) -VASc scores are useful
to stratify embolic risks in patients with non-valvular atrial fibrillation (NVAF)
and to identify patients eligible for anticoagulation. Although the risk of stoke
increases in patients with higher CHADS(2) or CHA(2) DS(2) -VASc scores, it is
uncertain why the stroke rate increases in them. Concomitant potential cardiac
sources of embolism (PCSE) may be more frequent in patients with higher CHADS(2) or
CHA(2) DS(2) -VASc scores because stroke risks increase when concomitant PCSE is
present in Atrial fibrillation (AF). On the other hand, atherothrombosis may be the
cause when considering that most components of the CHADS(2) and CHA(2) DS(2) -VASc
scores are risk factors for atherosclerosis. METHODS: Amongst 5493 stroke patients
who were prospectively registered with the stroke registry for 11years, 860
consecutive patients with NVAF were included for this study. We investigated the
mechanisms of stroke according to the CHADS(2) /CHA(2) DS(2) -VASc score in stroke
patients with NVAF. RESULTS: Amongst 860 patients, concomitant PCSE were found in
334 patients (38.8%). The number of PCSE increased as the CHADS(2) /CHA(2) DS(2)
-VASc score increased (P<0.001). Of individual PCSE, akinetic left ventricular
segment, hypokinetic left ventricular segment and myocardial infarction <4weeks
were associated with the CHADS(2) /CHA(2) DS(2) -VASc score. The presence of
possible atherothrombotic mechanism, in addition to AF, was suggested in 27.3%. The
proportion of patients with concomitant presence of possible atherothrombosis was
increased as the CHADS(2) /CHA(2) DS(2) -VASc score increased (P<0.001).
CONCLUSIONS: Increased frequency of concomitant PCSE and that of the
atherothrombotic mechanism may explain the high risk of stroke in patients with
higher CHADS(2) /CHA(2) DS(2) -VASc score.
AD - Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
AN - 21972975
AU - Cha, M. J.
AU - Kim, Y. D.
AU - Nam, H. S.
AU - Kim, J.
AU - Lee, D. H.
AU - Heo, J. H.
DA - Mar
DO - 10.1111/j.1468-1331.2011.03547.x
DP - NLM
ET - 2011/10/07
IS - 3
J2 - European journal of neurology
KW - Aged
Cardiovascular Diseases/complications
Coronary Thrombosis/etiology
Female
Humans
Male
Risk Factors
Stroke/*etiology
Thromboembolism/*etiology
LA - eng
N1 - 1468-1331
Cha, M-J
Kim, Y D
Nam, H S
Kim, J
Lee, D H
Heo, J H
Journal Article
England
Eur J Neurol. 2012 Mar;19(3):473-9. doi: 10.1111/j.1468-1331.2011.03547.x. Epub
2011 Oct 4.
PY - 2012
SN - 1351-5101
SP - 473-9
ST - Stroke mechanism in patients with non-valvular atrial fibrillation according
to the CHADS2 and CHA2 DS2 -VASc scores
T2 - Eur J Neurol
TI - Stroke mechanism in patients with non-valvular atrial fibrillation according
to the CHADS2 and CHA2 DS2 -VASc scores
VL - 19
ID - 2604
ER -
TY - JOUR
AB - OBJECTIVE: To report a fatal case of amiodarone-induced acute hepatotoxicity
after intravenous amiodarone administration and similar fatal cases review. CASE
SUMMARY: A 72-year-old woman with a history of hypertension, prior cardiovascular
disease, atrial fibrillation and diabetes mellitus was admitted to the hospital
with acute pyelonephritis and transferred to the intensive care unit due to
cerebral infarction. An antidiabetic drug, a low dose of aspirin and intravenous
amiodarone therapy was started. After receiving a second dose of amiodarone (1,200
mg; injection rate 1 mg/min), the woman developed ascites, jaundice, high levels of
serum transaminases, decreased prothrombin time, and finally became unconscious.
Immediately after treatment was discontinued, her extremely high hepatic parameters
returned to normal. According to the Naranjo probability scale, this adverse
reaction was highly probable. DISCUSSION: The occurrence of acute liver damage
after intravenous amiodarone is rare but harmful. It can be induced by polysorbate
80, a solubilizer, by immunomediated centrilobular necrosis, or by the presence of
a functional PPAR-I+/- gene. CONCLUSION: Amiodarone is an effective antiarrhythmic
agent for preventing and treating atrial and ventricular arrhythmias. The molecular
mechanism causing acute hepatic damage after amiodarone treatment is not clear.
Therefore, amiodarone must be administered with care, and liver function should be
monitored closely in patients treated with this drug.
AD - Department of Pharmacy, Chi Mei Medical Center, Tainan, Taiwan.
AN - 18218290
AU - Chan, A. L.
AU - Hsieh, H. J.
AU - Hsieh, Y. A.
AU - Lin, S. J.
DA - Feb
DO - 10.5414/cpp46096
DP - NLM
ET - 2008/01/26
IS - 2
J2 - International journal of clinical pharmacology and therapeutics
KW - Aged
Amiodarone/*adverse effects/therapeutic use
Anti-Arrhythmia Agents/*adverse effects/therapeutic use
Atrial Fibrillation/drug therapy
*Chemical and Drug Induced Liver Injury
Fatal Outcome
Female
Hepatomegaly/chemically induced
Humans
LA - eng
N1 - Chan, A L F
Hsieh, H J
Hsieh, Y-A
Lin, S-J
Case Reports
Journal Article
Review
Germany
Int J Clin Pharmacol Ther. 2008 Feb;46(2):96-101. doi: 10.5414/cpp46096.
PY - 2008
SN - 0946-1965 (Print)
0946-1965
SP - 96-101
ST - Fatal amiodarone-induced hepatotoxicity: a case report and literature review
T2 - Int J Clin Pharmacol Ther
TI - Fatal amiodarone-induced hepatotoxicity: a case report and literature review
VL - 46
ID - 3023
ER -
TY - JOUR
AB - Acute carbamate intoxication can cause cardiac manifestations. We present the
case of a 53-year-old man who had been a heavy smoker, admitted to our hospital for
recent anterior wall myocardial infarction complicated with congestive heart
failure. Percutaneous transluminal coronary angioplasty with stent implantation,
coronary artery bypass graft, and mitral annuloplasty were performed, but
refractory heart failure and ventricular arrhythmia were still noted. He received
orthotropic heart transplantation 7 days later. The donor was a 50-year-old man who
had died of brain death due to carbamate intoxication, and the crossmatch before
transplantation was negative. The recipient died 24 hours after the operation due
to acute left ventricular dysfunction. This report reviews the cardiac
manifestations of acute carbamate intoxication and the possibility of heart
transplantations from donors who died of carbamate intoxication.
AD - Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial
Hospital, Chang Gung University College of Medicine, Taipei, Taiwan.
AN - 22030195
AU - Chan, Y. H.
AU - Liew, K. P.
AU - Sun, C. C.
AU - Hsueh, C.
AU - Li, B. C.
AU - Tsai, F. C.
AU - Lin, J. L.
AU - Chu, P. H.
DA - Oct
DO - 10.1016/j.ajem.2011.09.002
DP - NLM
ET - 2011/10/28
IS - 8
J2 - The American journal of emergency medicine
KW - Acute Disease
Carbamates/*poisoning
Fatal Outcome
Graft Rejection/*etiology
Heart/drug effects
Heart Transplantation/*adverse effects
Humans
Male
Middle Aged
*Tissue Donors
LA - eng
N1 - 1532-8171
Chan, Yi-Hsin
Liew, Kuo-Ping
Sun, Charles Chien-Feng
Hsueh, Chuen
Li, Bing-Chin
Tsai, Feng-Chun
Lin, Ja-Liang
Chu, Pao-Hsien
Case Reports
Journal Article
United States
Am J Emerg Med. 2012 Oct;30(8):1661.e1-4. doi: 10.1016/j.ajem.2011.09.002. Epub
2011 Oct 24.
PY - 2012
SN - 0735-6757
SP - 1661.e1-4
ST - Hyperacute rejection from a donor who died of carbamate intoxication--a case
report
T2 - Am J Emerg Med
TI - Hyperacute rejection from a donor who died of carbamate intoxication--a case
report
VL - 30
ID - 3083
ER -
TY - JOUR
AB - BACKGROUND: Digoxin and related cardiac glycosides have been used for almost
100 years in atrial fibrillation (AF). However, 2 recent analyses of the Atrial
Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) trial showed
inconsistent results regarding the risk of mortality associated with digoxin use.
The goal of the present study was to investigate the relationship between digoxin
and the risk of ischemic stroke and mortality in Asians. METHODS: This study used
the National Health Insurance Research Database (NHIRD) in Taiwan. A total of 4781
patients with AF who did not receive any antithrombotic therapy were selected as
the study population. Among the study population, 829 participants (17.3%) received
the digoxin treatment. The risk of ischemic stroke and mortality in patients who
received digoxin and those who did not was compared. RESULTS: The use of digoxin
was associated with an increased risk of clinical events, with an adjusted hazard
ratio of 1.41 (95% confidence interval [CI], 1.17-1.70) for ischemic stroke and
1.21 (95% CI, 1.01-1.44) for all-cause mortality. In the subgroup analysis based on
coexistence with heart failure or not, digoxin was a risk factor for adverse events
in patients without heart failure but not in those with heart failure (interaction
P < 0.001 for either end point). Among patients with AF without heart failure, the
use of β-blockers was associated with better survival, with an adjusted hazard
ratio of 0.48 (95% CI, 0.34-0.68). CONCLUSIONS: Digoxin should be avoided for
patients with AF without heart failure because it was associated with an increased
risk of clinical events. β-Blockers may be a better choice for controlling
ventricular rate in these patients.
AD - Division of Cardiology, Department of Medicine, Taipei Veterans General
Hospital, Taipei, Taiwan; Institute of Clinical Medicine and Cardiovascular
Research Center, National Yang-Ming University, Taipei, Taiwan.
Division of Hematology and Oncology, Department of Medicine, Taipei Veterans
General Hospital, Taipei, Taiwan; Institute of Public Health and School of
Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Internal
Medicine, National Yang-Ming University Hospital, I-Lan, Taiwan.
Institute of Public Health and School of Medicine, National Yang-Ming University,
Taipei, Taiwan; Division of Infectious Diseases, Department of Medicine, Taipei
Veterans General Hospital Su-Ao and Yuanshan Branch, I-Lan, Taiwan.
Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital,
Taipei, Taiwan; Institute of Clinical Medicine and Cardiovascular Research Center,
National Yang-Ming University, Taipei, Taiwan; General Clinical Research Center,
Taipei Veterans General Hospital, Taipei, Taiwan; Department of Medical Research
and Education, Taipei Veterans General Hospital, Taipei, Taiwan. Electronic
address: cechiang@vghtpe.gov.tw.
Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital,
Taipei, Taiwan; Institute of Clinical Medicine and Cardiovascular Research Center,
National Yang-Ming University, Taipei, Taiwan. Electronic address:
epsachen@ms41.hinet.net.
AN - 25262860
AU - Chao, T. F.
AU - Liu, C. J.
AU - Chen, S. J.
AU - Wang, K. L.
AU - Lin, Y. J.
AU - Chang, S. L.
AU - Lo, L. W.
AU - Hu, Y. F.
AU - Tuan, T. C.
AU - Chen, T. J.
AU - Chiang, C. E.
AU - Chen, S. A.
DA - Oct
DO - 10.1016/j.cjca.2014.05.009
DP - NLM
ET - 2014/09/30
IS - 10
KW - Anti-Arrhythmia Agents/*adverse effects/therapeutic use
Atrial Fibrillation/*complications/drug therapy/*mortality
Brain Ischemia/*epidemiology
Cohort Studies
Digoxin/*adverse effects/therapeutic use
Humans
Risk Factors
Stroke/*epidemiology
LA - eng
N1 - 1916-7075
Chao, Tze-Fan
Liu, Chia-Jen
Chen, Su-Jung
Wang, Kang-Ling
Lin, Yenn-Jiang
Chang, Shih-Lin
Lo, Li-Wei
Hu, Yu-Feng
Tuan, Ta-Chuan
Chen, Tzeng-Ji
Chiang, Chern-En
Chen, Shih-Ann
Journal Article
England
Can J Cardiol. 2014 Oct;30(10):1190-5. doi: 10.1016/j.cjca.2014.05.009. Epub 2014
May 14.
PY - 2014
SN - 0828-282x
SP - 1190-5
ST - Does digoxin increase the risk of ischemic stroke and mortality in atrial
fibrillation? A nationwide population-based cohort study
T2 - Can J Cardiol
TI - Does digoxin increase the risk of ischemic stroke and mortality in atrial
fibrillation? A nationwide population-based cohort study
VL - 30
ID - 2353
ER -
TY - JOUR
AB - The prolonged voluntary closure of the glottis during the supraglottic and
super-supraglottic swallowing techniques may create the Valsalva maneuver. The
Valsalva maneuver has been associated with sudden cardiac death and cardiac
arrhythmias. This study describes the effects of the supraglottic and super-
supraglottic swallowing techniques on the cardiovascular system. Subjects included
23 patients from an acute inpatient rehabilitation hospital. Subject groups
included recent stroke, dysphagia. and a history of coronary artery disease (Group
1, N = 11). recent stroke and dysphagia with no known coronary artery disease
(Group 2, N = 4), and orthopedic diagnosis with no known dysphagia or coronary
artery disease (Group 3, N = 8). Cardiac status was monitored for 4 hours during
swallowing training, regular therapy sessions, and a meal. For Groups I and 2,
86.6% (13 out of 15) of the subjects demonstrated abnormal cardiac findings during
the swallowing session including supraventricular tachycardia, premature atrial
contractions, and premature ventricular contractions. Arrhythmia subsided within a
few minutes after the session and did not occur during other activities. In Group 3
(control group), none of the subjects demonstrated abnormal cardiac findings except
for bradycardia in one subject. It is suggested that the supraglottic and super-
supraglottic swallow maneuvers may be contraindicated for patients with a history
of stroke or coronary artery disease.
AD - Marianjoy Rehabilitation Hospital, Wheaton, Illinois 60187, USA.
AN - 11820383
AU - Chaudhuri, G.
AU - Hildner, C. D.
AU - Brady, S.
AU - Hutchins, B.
AU - Aliga, N.
AU - Abadilla, E.
DA - Winter
DO - 10.1007/s00455-001-0097-1
DP - NLM
ET - 2002/02/01
IS - 1
J2 - Dysphagia
KW - Adult
Aged
Aged, 80 and over
*Deglutition Disorders/etiology/physiopathology/therapy
Electrocardiography
Glottis/*physiopathology
Humans
Middle Aged
*Valsalva Maneuver
LA - eng
N1 - Chaudhuri, Gouri
Hildner, Cynthia D
Brady, Susan
Hutchins, Brad
Aliga, Norman
Abadilla, Eileen
Journal Article
United States
Dysphagia. 2002 Winter;17(1):19-23. doi: 10.1007/s00455-001-0097-1.
PY - 2002
SN - 0179-051X (Print)
0179-051x
SP - 19-23
ST - Cardiovascular effects of the supraglottic and super-supraglottic swallowing
maneuvers in stroke patients with dysphagia
T2 - Dysphagia
TI - Cardiovascular effects of the supraglottic and super-supraglottic swallowing
maneuvers in stroke patients with dysphagia
VL - 17
ID - 2690
ER -
TY - JOUR
AB - OBJECTIVE: To assess heart rhythm and predictive factors associated with
sinus rhythm after one year in patients with rheumatic valve disease undergoing
concomitant surgical treatment of atrial fibrillation. Operative mortality,
survival and occurrence of stroke after one year were also evaluated. METHODS:
Retrospective longitudinal observational study of 103 patients undergoing rheumatic
mitral valve surgery and ablation of atrial fibrillation using uni- or bipolar
radiofrequency between January 2013 and December 2014. Age, gender, functional
class (NYHA), type of atrial fibrillation, EuroSCORE, duration of atrial
fibrillation, stroke, left atrial size, left ventricular ejection fraction,
cardiopulmonary bypass time, myocardial ischemia time and type of radiofrequency
were investigated. RESULTS: After one year, 66.3% of patients were in sinus rhythm.
Sinus rhythm at hospital discharge, lower left atrial size in the preoperative
period and bipolar radiofrequency were associated with a greater chance of sinus
rhythm after one year. Operative mortality was 7.7%. Survival rate after one year
was 92.3% and occurrence of stroke was 1%. CONCLUSION: Atrial fibrillation ablation
surgery with surgical approach of rheumatic mitral valve resulted in 63.1% patients
in sinus rhythm after one year. Discharge from hospital in sinus rhythm was a
predictor of maintenance of this rhythm. Increased left atrium and use of unipolar
radiofrequency were associated with lower chance of sinus rhythm. Operative
mortality rate of 7.7% and survival and stroke-free survival contribute to
excellent care results for this approach.
AD - Instituto Nacional de Cardiologia (INC), Rio de Janeiro, RJ, Brazil.
Universidade Federal Fluminense (UFF), Niterói, RJ, Brazil.
AN - 28832799
AU - Chavez, E. K.
AU - Colafranceschi, A. S.
AU - Monteiro, A. J. O.
AU - Canale, L. S.
AU - Mesquita, E. T.
AU - Weksler, C.
AU - Barbosa, O. N.
AU - Oliveira, A.
C2 - PMC5570393
DA - May-Jun
DO - 10.21470/1678-9741-2017-0016
DP - NLM
ET - 2017/08/24
IS - 3
J2 - Brazilian journal of cardiovascular surgery
KW - Adult
Age Factors
Aged
Atrial Fibrillation/mortality/physiopathology/*surgery
Cardiopulmonary Bypass
Catheter Ablation/methods/mortality
Female
Heart Rate/physiology
Heart Valve Diseases/mortality/physiopathology/*surgery
Humans
Male
Middle Aged
Mitral Valve/physiopathology/surgery
Rheumatic Heart Disease/mortality/physiopathology/*surgery
Risk Factors
Sex Factors
Stroke/physiopathology
Time Factors
Treatment Outcome
Young Adult
LA - eng
N1 - 1678-9741
Chavez, Ernesto Koehler
Colafranceschi, Alexandre Siciliano
Monteiro, Andrey José de Oliveira
Canale, Leonardo Secchin
Mesquita, Evandro Tinoco
Weksler, Clara
Barbosa, Odilon Nogueira
Oliveira, Anderson
Journal Article
Observational Study
Braz J Cardiovasc Surg. 2017 May-Jun;32(3):202-209. doi: 10.21470/1678-9741-2017-
0016.
PY - 2017
SN - 0102-7638 (Print)
0102-7638
SP - 202-209
ST - Surgical Treatment of Atrial Fibrillation in Patients with Rheumatic Valve
Disease
T2 - Braz J Cardiovasc Surg
TI - Surgical Treatment of Atrial Fibrillation in Patients with Rheumatic Valve
Disease
VL - 32
ID - 2390
ER -
TY - JOUR
AB - Non-intensive telemetry units are utilized for monitoring patients at risk
for life-threatening dysrhythmias and sudden death. Physicians often use monitored
beds for patients who might only require frequent nursing care. When 70% of the top
10 diseases admitted through the emergency department (ED) are clinically indicated
for telemetry, hospitals with limited resources will be overwhelmed and admitted
patients will be forced to wait in the ED. We examine the evidence behind admitting
patients to telemetry. There is evidence for monitoring in patients admitted for
implantable cardioverter-defibrillator firing, type II and complete atrio-
ventricular block, prolonged QT interval with ventricular arrhythmia, decompensated
heart failure, acute cerebrovascular event, acute coronary syndrome, and massive
blood transfusion. Monitoring is beneficial for selected patients with syncope,
gastrointestinal hemorrhage, atrial tachyarrhythmias, and uncorrected electrolyte
abnormalities. Finally, telemetry is not indicated for patients requiring minor
blood transfusion, low risk chest pain patients with normal electrocardiography,
and stable patients receiving anticoagulation for pulmonary embolism.
AD - Department of Emergency Medicine, University of Pennsylvania, Philadelphia,
Pennsylvania 19104, USA.
AN - 17630076
AU - Chen, E. H.
AU - Hollander, J. E.
DA - Jul
DO - 10.1016/j.jemermed.2007.01.017
DP - NLM
ET - 2007/07/17
IS - 1
J2 - The Journal of emergency medicine
KW - Arrhythmias, Cardiac/diagnosis
Cardiovascular Diseases/*diagnosis
Death, Sudden, Cardiac/*prevention & control
Humans
Lung Diseases/*diagnosis
*Patient Selection
Stroke/diagnosis
Telemetry/*statistics & numerical data
LA - eng
N1 - Chen, Esther H
Hollander, Judd E
Journal Article
Review
United States
J Emerg Med. 2007 Jul;33(1):53-60. doi: 10.1016/j.jemermed.2007.01.017. Epub 2007
May 30.
PY - 2007
SN - 0736-4679 (Print)
0736-4679
SP - 53-60
ST - When do patients need admission to a telemetry bed?
T2 - J Emerg Med
TI - When do patients need admission to a telemetry bed?
VL - 33
ID - 2523
ER -
TY - JOUR
AB - BACKGROUND: Sympathetic overactivation after acute myocardial infarction
(AMI) contributes to ventricular arrhythmia (VA). Paraventricular nucleus (PVN) of
the hypothalamus may play an important role on this context, however, the
mechanisms remain unknown. In this study, we investigated whether inhibition of
activated astrocytes in the PVN could reduce VA in rats with AMI. METHODS: The
anesthetized rats were randomly divided into four groups of sham-operated, AMI,
AMI + vehicle and AMI + fluorocitrate (FCA). Electrocardiogram was continuously
recorded. RNA sequencing, sympathetic nerve activity (heart rate variability and
norepinephrine levels) and ventricular electrical instability (ventricular
effective refractory period and ventricular fibrillation inducibility) were
measured. Furthermore, brain tissues were extracted to detect expression of
inflammatory cytokines (IL-6, and TNF-α), astrocyte and neuro activation. RESULTS:
RNA sequencing analysis showed that functions of differentially expressed genes in
the PVN of AMI rats were significantly enriched in immune system- and neuroactive-
related pathways, along with enhance expression of cytokines and Glial fibrillary
acidic protein (GFAP). We further characterized that astrocytes were activated in
PVN and intervention of activation astrocytes by FCA significantly inhibited
sympathetic nerve activity and decreased the incidence of VA and ventricular
electrical instability in rats with AMI. Moreover, FCA significantly attenuated
neurons activation and downregulated expression of inflammatory cytokines in the
PVN. CONCLUSIONS: Inhibition of activated astrocytes in the PVN could reduce VA
occurrence and improve ventricular electrical instability in AMI rats by central
neuro-immune pathway. These findings suggest that astrocytes are a potential target
for prevention and treatment of VA complicating AMI.
AD - Department of Cardiology, The First Affiliated Hospital of Harbin Medical
University, Harbin, China.
Department of Neonatology, The First Affiliated Hospital of Xinxiang Medical
University, Xinxiang, China.
Department of Internal Medicine, BronxCare Health System, NY, USA.
Department of Anesthesiology, The First Affiliated Hospital of Harbin Medical
University, Harbin, China.
Department of Cardiology, The First Affiliated Hospital of Harbin Medical
University, Harbin, China. Electronic address: qxf0717@126.com.
AN - 31987663
AU - Chen, J.
AU - Yin, D.
AU - He, X.
AU - Gao, M.
AU - Choi, Y.
AU - Luo, G.
AU - Wang, H.
AU - Qu, X.
DA - Jun 1
DO - 10.1016/j.ijcard.2020.01.035
DP - NLM
ET - 2020/01/29
KW - *Acute myocardial infarction
*Astrocyte
*Paraventricular nucleus
*Transcriptome sequencing
*Ventricular arrhythmia
statistical analysis, and Personal Biotechnology Cp. Ltd, Shanghai, China for the
help and advice for RNA-Seq. This study was funded by Postgraduate Research &
Practice Innovation Program of Harbin Medical University (YJSKYCX2018-27HYD), the
China Postdoctoral Science Foundation (2018M631959), Science Foundation of the
First
Affiliated Hospital of Harbin Medical University (2018L001) and the Postdoctoral
Science-Research Developmental Foundation of Heilongjiang Province (LBH-Z18213).
The
authors declare that they have no competing interests.
LA - eng
N1 - 1874-1754
Chen, Jugang
Yin, Dechun
He, Xiaojing
Gao, Meng
Choi, Yongsub
Luo, Guanghui
Wang, Haixing
Qu, Xiufen
Journal Article
Netherlands
Int J Cardiol. 2020 Jun 1;308:33-41. doi: 10.1016/j.ijcard.2020.01.035. Epub 2020
Jan 16.
PY - 2020
SN - 0167-5273
SP - 33-41
ST - Modulation of activated astrocytes in the hypothalamus paraventricular
nucleus to prevent ventricular arrhythmia complicating acute myocardial infarction
T2 - Int J Cardiol
TI - Modulation of activated astrocytes in the hypothalamus paraventricular
nucleus to prevent ventricular arrhythmia complicating acute myocardial infarction
VL - 308
ID - 3062
ER -
TY - JOUR
AB - The degree to which clinical outcomes are worsened in patients with atrial
fibrillation (AF) with heart failure (HF) compared with those without HF is not
well described. This study aimed to determine the impact of HF on clinical outcomes
in patients with AF. We analyzed data from Outcomes Registry for Better Informed
Treatment of Atrial Fibrillation, a national registry of 10,135 patients with AF to
determine associations between HF and left ventricular ejection fraction (LVEF) and
outcomes, including stroke, mortality, and hospitalization using Cox multivariable
modeling. Atrial Fibrillation Effect on Quality-of-Life Questionnaire (AFEQT)
scores between groups were also compared. Overall, 33% (n = 3,203) of patients had
HF; of these 33% (n = 985) had LVEF ≤40%. Oral anticoagulation was prescribed more
commonly in patients with HF (81% vs 74%). Compared with patients without HF, those
with HF had similar rate of stroke (1.28 vs 0.88 per 100-patient years, hazard
ratio [HR] 1.11, confidence interval [CI] 0.83 to 1.48, p = 0.47) but higher
mortality (HR 1.69, CI 1.49 to 1.92, p <0.001) and hospitalization (HR 1.31, CI
1.23 to 1.39, p <0.0001). Patients with LVEF ≤40% had similar stroke risk (HR 1.06,
CI 0.67 to 1.67) but higher mortality (HR 2.06, CI 1.74 to 2.44) and
hospitalization (HR 1.38, CI 1.25 to 1.51). AFEQT overall score was significantly
lower (76.9 vs 83.3, p <0.0001) in patients with HF. In conclusion, HF was
associated with increased risk of death and hospitalization and worse quality of
life, but similar rates of thromboembolism regardless of LVEF among patients with
AF. These findings highlight the need to develop therapeutic strategies targeting
functional status and survival for patients with HF and AF.
AD - Department of Medicine, Stanford University School of Medicine, Stanford,
California. Electronic address: tscherian@gmail.com.
Duke Clinical Research Institute, Durham, North Carolina.
UCLA Division of Cardiology, Los Angeles, California.
Division of Cardiology, University of Colorado School of Medicine, Denver,
Colorado.
Institute for Medical Research, Wynnewood, Pennsylvania.
Mayo Clinic, Rochester, Minnesota.
Department of Medicine, Stanford University School of Medicine, Stanford,
California.
AN - 28416199
AU - Cherian, T. S.
AU - Shrader, P.
AU - Fonarow, G. C.
AU - Allen, L. A.
AU - Piccini, J. P.
AU - Peterson, E. D.
AU - Thomas, L.
AU - Kowey, P. R.
AU - Gersh, B. J.
AU - Mahaffey, K. W.
DA - Jun 1
DO - 10.1016/j.amjcard.2017.02.050
DP - NLM
ET - 2017/04/19
IS - 11
KW - Aged
Aged, 80 and over
Atrial Fibrillation/*complications/epidemiology/therapy
Female
Follow-Up Studies
Heart Failure/*complications/mortality/therapy
Hospitalization/trends
Humans
Male
Outpatients/statistics & numerical data
Prevalence
Prognosis
Prospective Studies
*Quality of Life
*Registries
Risk Factors
Surveys and Questionnaires
Thrombolytic Therapy/*methods
LA - eng
N1 - 1879-1913
Cherian, Tharian S
Shrader, Peter
Fonarow, Gregg C
Allen, Larry A
Piccini, Jonathan P
Peterson, Eric D
Thomas, Laine
Kowey, Peter R
Gersh, Bernard J
Mahaffey, Kenneth W
Journal Article
Multicenter Study
United States
Am J Cardiol. 2017 Jun 1;119(11):1763-1769. doi: 10.1016/j.amjcard.2017.02.050.
Epub 2017 Mar 16.
PY - 2017
SN - 0002-9149
SP - 1763-1769
ST - Effect of Atrial Fibrillation on Mortality, Stroke Risk, and Quality-of-Life
Scores in Patients With Heart Failure (from the Outcomes Registry for Better
Informed Treatment of Atrial Fibrillation [ORBIT-AF])
T2 - Am J Cardiol
TI - Effect of Atrial Fibrillation on Mortality, Stroke Risk, and Quality-of-Life
Scores in Patients With Heart Failure (from the Outcomes Registry for Better
Informed Treatment of Atrial Fibrillation [ORBIT-AF])
VL - 119
ID - 2499
ER -
TY - JOUR
AB - Transcatheter aortic valve implantation (TAVI) has become an alternative
therapeutic option for patients with symptomatic severe aortic stenosis at high
surgical risk and the standard of care in patients who are inoperable for open
aortic valve replacement. With technological evolution and increasing experience,
the procedure has become more predictable. Complications of TAVI, however, are not
infrequent, and can range from minor to life-threatening events. Stroke,
paravalvular leak, various forms of atrioventricular block, including the need for
permanent pacemakers and aortic annular and ventricular perforation will be the
focus of the present review. Other complications associated with TAVI (such as
vascular injury, acute kidney injury, coronary obstruction, valve malpositioning or
migration) are clinically important, but are beyond the scope of this article.
Understanding the occurrence and pathophysiology of these complications may provide
insights into the improvement of the transcatheter devices and techniques, and aid
in extending the application of TAVI to a broader population.
AD - Department of Cardiology, National Heart Centre Singapore, 17 Third Hospital
Avenue, Mistri Wing, 168752 Singapore.
AN - 24020674
AU - Chiam, P. T.
AU - Ewe, S. H.
DA - Sep
DO - 10.2217/fca.13.43
DP - NLM
ET - 2013/09/12
IS - 5
J2 - Future cardiology
KW - Aortic Valve Stenosis/*surgery
Atrioventricular Block/*etiology
Cardiac Catheterization/*adverse effects
Heart Injuries/*etiology
Heart Valve Prosthesis Implantation/*adverse effects
Heart Ventricles/injuries
Humans
Rupture
Stroke/*etiology
Treatment Failure
LA - eng
N1 - 1744-8298
Chiam, Paul T L
Ewe, See Hooi
Journal Article
Review
England
Future Cardiol. 2013 Sep;9(5):733-47. doi: 10.2217/fca.13.43.
PY - 2013
SN - 1479-6678
SP - 733-47
ST - An update on complications associated with transcatheter aortic valve
implantation: stroke, paravalvular leak, atrioventricular block and perforation
T2 - Future Cardiol
TI - An update on complications associated with transcatheter aortic valve
implantation: stroke, paravalvular leak, atrioventricular block and perforation
VL - 9
ID - 2476
ER -
TY - JOUR
AB - Ninety-five patients aged 60 years or over with a permanent pacemaker
implanted for sick sinus syndrome were divided into two groups: 32 patients with
physiological pacing (group P) and 63 patients with ventricular pacing (group V).
The mean follow-up period was 45.0 +/- 36.6 months in group P and 50.3 +/- 37.8
months in group V. Paroxysmal atrial fibrillation (Af) occurred in 28% of group P
and 71% of group V (p < 0.05). The incidence of stable Af was also lower in group P
than in group V (9% vs. 30%, p < 0.05). None of group P with only bradyarrhythmia
had stable Af. However, 6 of 21 patients (29%) in group V with bradyarrhythmia
showed stable Af. There was no significant difference in stable Af between group P
with bradycardia-tachycardia syndrome (BTS) and group V with BTS (19% vs. 31%). A
lower incidence of embolic events was also observed in group P (3% vs. 25%, p <
0.05). Nine of 16 patients with embolic events in group V died of complications
following embolism (8 patients; cerebral embolism, one patients: renal and superior
mesenteric arterial embolism). The survival rates at 5 and 10 years were 80% and
69%, respectively, for group P and 56% and 33% for group V (p < 0.01). Thus, with
regard to permanent pacing for patients with sick sinus syndrome, physiological
pacing should be selected for control of morbidity and total mortality.
AD - Division of Cardiology, Tokyo Metropolitan Geriatric Hospital.
AN - 8301858
AU - Chida, K.
AU - Ohkawa, S.
AU - Imai, T.
AU - Suzuki, Y.
AU - Ishikawa, K.
AU - Watanabe, C.
AU - Kuramoto, K.
AU - Suzuki, Y.
AU - Kaku, T.
AU - Ueda, K.
DA - Oct
DP - NLM
ET - 1993/10/01
IS - 10
KW - Aged
Cardiac Pacing, Artificial/*mortality
Female
Follow-Up Studies
Heart Ventricles
Humans
Male
Middle Aged
Sick Sinus Syndrome/mortality/*therapy
Survival Rate
LA - jpn
N1 - Chida, K
Ohkawa, S
Imai, T
Suzuki, Y
Ishikawa, K
Watanabe, C
Kuramoto, K
Kaku, T
Ueda, K
Comparative Study
English Abstract
Journal Article
Japan
Nihon Ronen Igakkai Zasshi. 1993 Oct;30(10):869-78. doi: 10.3143/geriatrics.30.869.
PY - 1993
SN - 0300-9173 (Print)
0300-9173
SP - 869-78
ST - [Long-term follow-up study after permanent pacemaker implantation in patients
aged 60 years or over with sick sinus syndrome]
TI - [Long-term follow-up study after permanent pacemaker implantation in patients
aged 60 years or over with sick sinus syndrome]
VL - 30
ID - 2924
ER -
TY - JOUR
AB - BACKGROUND: Standard 12-lead electrocardiography is a routine and mandatory
cardiovascular examination in the evaluation of stroke patients. This study
investigates the relationship of electrocardiography findings and first-ever
ischemic stroke. METHODS: This hospital-based case-control study consisted of 238
consecutively hospitalized cases of first-ever ischemic stroke and 238 healthy age-
and sex-matched control subjects. Multivariate logistic regression analyses were
performed to evaluate the risk factors and electrocardiography findings. RESULTS:
Atrial fibrillation [odds ratio (OR) = 6.8, 95% confidence interval (CI) =1.90-
24.45], myocardial ischemic change (OR = 5.0, 95% CI = 2.22-11.06), left
ventricular hypertrophy (OR = 3.9, 95% CI = 2.02-7.39) and sinus bradycardia (OR =
0.37, 95% CI = 0.18-0.79) were significantly related with first-ever ischemic
stroke. CONCLUSIONS: Electrocardiography findings of atrial fibrillation,
myocardial ischemic change and left ventricular hypertrophy as risk factors for
ischemic stroke were similar to those from other studies. Additional studies are
needed to assess the role of sinus bradycardia for ischemic stroke, which was less
common in patients with stroke than in controls.
AD - First Department of Neurology, Chang Gung Memorial Hospital-Kaohsiung Medical
Center, Taiwan.
AN - 17214085
AU - Chiu, E. H.
AU - Tan, T. Y.
AU - Chang, K. C.
AU - Liou, C. W.
DA - Dec
DP - NLM
ET - 2007/01/12
IS - 4
J2 - Acta neurologica Taiwanica
KW - Adolescent
Adult
Aged
Aged, 80 and over
Female
Humans
Male
Middle Aged
Myocardial Ischemia/complications
Risk Factors
Stroke/*etiology
LA - eng
N1 - Chiu, Elley H H
Tan, Teng-Yeow
Chang, Ku-Chou
Liou, Chia-Wei
Journal Article
China (Republic : 1949- )
Acta Neurol Taiwan. 2006 Dec;15(4):232-6.
PY - 2006
SN - 1028-768X (Print)
1028-768x
SP - 232-6
ST - Risk factors for ischemic stroke: electrocardiographic findings
T2 - Acta Neurol Taiwan
TI - Risk factors for ischemic stroke: electrocardiographic findings
VL - 15
ID - 2553
ER -
TY - JOUR
AN - 15315915
AU - Choudhury, A.
AU - Lip, G. Y.
DA - Sep
DO - 10.1093/ageing/afh185
DP - NLM
ET - 2004/08/19
IS - 5
J2 - Age and ageing
KW - Aged
Atrial Fibrillation/diagnosis/drug therapy/*epidemiology
Cerebral Infarction/epidemiology/prevention & control
Cooperative Behavior
Geriatric Assessment/statistics & numerical data
Health Services Needs and Demand/*statistics & numerical data
Humans
Mass Screening
Patient Care Team
Risk
Ventricular Dysfunction, Left/diagnosis/drug therapy/*epidemiology
LA - eng
N1 - Choudhury, Anirban
Lip, Gregory Y H
Comment
Editorial
England
Age Ageing. 2004 Sep;33(5):434-6. doi: 10.1093/ageing/afh185.
PY - 2004
SN - 0002-0729 (Print)
0002-0729
SP - 434-6
ST - Left ventricular systolic dysfunction and atrial fibrillation in older people
in the community: the need for identification, as well as appropriate management
T2 - Age Ageing
TI - Left ventricular systolic dysfunction and atrial fibrillation in older people
in the community: the need for identification, as well as appropriate management
VL - 33
ID - 2764
ER -
TY - JOUR
AB - Results of subarachnoid hemorrhage (SAH) in the acute phase are represented
by the direct threat of vasospasm. The first step still is to recognise SAH, so
that all misleading clinical aspects of arterial aneurysm rupture do not misguide,
or even fail to do the right diagnosis. If so, rebleeding still remains a real
danger. Among biological patterns, hyponatremia is an important factor of
vasospasm. Cardiovascular symptoms are represented by a sudden and transient
arterial hypertension which can drive to a diagnostic error and
electrocardiographic abnormalities, which are directly related with the degree of
vasospasm; their evolution is completely regressive. Main intracranial consequences
are early hydrocephalus, worsening of consciousness and progressive ventricular
distension on CT scan and vasospasm, which occurs between the 4th and the 12th day,
may be asymptomatic or symptomatic, responsive for delayed ischemia, followed by
deterioration of consciousness and focal neurological signs. The main factors
responsible for the vasospasm are a high amount of blood in basal cisterns on CT
scan; an increase of substances released by the lysis of hemoglobin in CSF;
hyponatremia, hypovolemia, and decrease in cerebral blood flow. Consequences of
these disorders have to be well known in the medical treatment before and after
operation.
AD - Service de neurochirurgie A, Centre hospitalier et universitaire, Lille.
AN - 2288334
AU - Christiaens, J. L.
DA - May
DP - NLM
ET - 1990/05/01
IS - 5
J2 - Agressologie: revue internationale de physio-biologie et de pharmacologie
appliquees aux effets de l'agression
KW - Arrhythmias, Cardiac/etiology
Cerebral Arterial Diseases/*etiology/therapy
Humans
Hydrocephalus/etiology
Hypertension/etiology
Hyponatremia/complications
Spasm/*etiology/therapy
Subarachnoid Hemorrhage/*complications/therapy
LA - fre
N1 - Christiaens, J L
English Abstract
Journal Article
France
Agressologie. 1990 May;31(5):241-2.
OP - Les conséquences des hémorragies méningées dans les premiers jours.
PY - 1990
SN - 0002-1148 (Print)
0002-1148
SP - 241-2
ST - [Consequences of meningeal hemorrhage during the first days after its onset]
T2 - Agressologie
TI - [Consequences of meningeal hemorrhage during the first days after its onset]
VL - 31
ID - 2900
ER -
TY - JOUR
AB - BACKGROUND: Dronedarone has been developed for treatment of atrial
fibrillation (AF) or atrial flutter (AFL). It is an amiodarone analogue but
noniodinized and without the same adverse effects as amiodarone. OBJECTIVE AND
METHODS: This is a review of 7 studies (DAFNE, ADONIS, EURIDIS, ATHENA, ANDROMEDA,
ERATO and DIONYSOS) on dronedarone focusing on efficacy, safety and prevention of
stroke. There was a dose-finding study (DAFNE), 3 studies focusing on maintenance
of sinus rhythm (ADONIS, EURIDIS and DIONYSOS), 1 study focusing on rate control
(ERATO) and 2 studies investigating mortality and morbidity (ANDROMEDA and ATHENA).
RESULTS: The target dose for dronedarone was established in the DAFNE study to be
400 mg twice daily. Both EURIDIS and ADONIS studies demonstrated that dronedarone
was superior to placebo for maintaining sinus rhythm. However, DIONYSOS found that
dronedarone is less efficient at maintaining sinus rhythm than amiodarone. ERATO
concluded that dronedarone reduces ventricular rate in patients with chronic AF.
The ANDROMEDA study in patients with severe heart failure was discontinued because
of increased mortality in dronedarone group. Dronedarone reduced cardiovascular
hospitalizations and mortality in patients with AF or AFL in the ATHENA trial.
Secondly, according to a post hoc analysis a significant reduction in stroke was
observed (annual rate 1.2% on dronedarone vs 1.8% on placebo, respectively [hazard
ratio 0.66, confidence interval 0.46 to 0.96, P = 0.027]). In total, 54 cases of
stroke occurred in 3439 patients (crude rate 1.6%) receiving dronedarone compared
to 76 strokes in 3048 patients on placebo (crude rate 2.5%), respectively.
CONCLUSION: Dronedarone can be used for maintenance of sinus rhythm and can reduce
stroke in patients with AF who receive usual care, which includes antithrombotic
therapy and heart rate control.
AD - Department of Cardiology, Gentofte Hospital, University of Copenhagen,
Hellerup, Denmark;
AN - 20396635
AU - Christiansen, C. B.
AU - Torp-Pedersen, C.
AU - Køber, L.
C2 - PMC2854052
DA - Apr 7
DO - 10.2147/cia.s8883
DP - NLM
ET - 2010/04/17
J2 - Clinical interventions in aging
KW - Amiodarone/administration & dosage/*analogs & derivatives/pharmacology
Anti-Arrhythmia Agents/administration & dosage/*pharmacology
Dronedarone
Humans
atrial fibrillation
stroke
LA - eng
N1 - 1178-1998
Christiansen, Christine Benn
Torp-Pedersen, Christian
Køber, Lars
Journal Article
Review
Clin Interv Aging. 2010 Apr 7;5:63-9. doi: 10.2147/cia.s8883.
PY - 2010
SN - 1176-9092 (Print)
1176-9092
SP - 63-9
ST - Impact of dronedarone in atrial fibrillation and flutter on stroke reduction
T2 - Clin Interv Aging
TI - Impact of dronedarone in atrial fibrillation and flutter on stroke reduction
VL - 5
ID - 2462
ER -
TY - JOUR
AB - PURPOSE: The pre-ejection period-derived myocardial performance index
measured from tissue Doppler echocardiography (PEPa-derived MPI) was reported to be
associated with left ventricular systolic and diastolic function in atrial
fibrillation (AF). However, its relationship with cardiovascular outcomes in AF has
never been evaluated. This study sought to examine the ability of PEPa-derived MPI
in predicting adverse cardiovascular events in AF patients. METHODS: In 196
persistent AF patients, we performed comprehensive echocardiography with
measurement of PEPa-derived MPI using index beat method. The index beat was defined
as the beat following the nearly equal preceding (RR1) and pre-preceding (RR2)
intervals. The cycle length of index beat and RR1 and RR2 must be >500ms and the
difference between RR1 and RR2 must be <60ms. Cardiovascular events were defined as
cardiovascular death, nonfatal stroke, and hospitalization for heart failure.
RESULTS: In the multivariate analysis, chronic heart failure and increased ratio of
transmitral E-wave velocity to early diastolic mitral annulus velocity (E/Ea) and
PEPa-derived MPI (per 0.1 increase, hazard ratio, 1.104; 95% confidence interval,
1.032-1.182, p=0.004) were associated with increased cardiovascular events. The
addition of PEPa-derived MPI to a Cox model containing chronic heart failure,
systolic blood pressure, age, diabetes, prior stroke, left ventricular ejection
fraction, and E/Ea provided an additional benefit in prediction of adverse
cardiovascular events (p=0.015). CONCLUSIONS: In AF patients, the PEPa-derived MPI
was a useful predictor of adverse cardiovascular events and could offer an
additional prognostic benefit over conventional clinical and echocardiographic
parameters.
AD - Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical
University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical
University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of
Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical
University, Kaohsiung, Taiwan.
University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Faculty of
Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of
Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical
University, Kaohsiung, Taiwan; Faculty of Medicine, College of Medicine, Kaohsiung
Medical University, Kaohsiung, Taiwan. Electronic address: cobeshm@seed.net.tw.
AN - 25156166
AU - Chu, C. Y.
AU - Lee, W. H.
AU - Hsu, P. C.
AU - Lee, H. H.
AU - Chiu, C. A.
AU - Su, H. M.
AU - Lin, T. H.
AU - Lee, C. S.
AU - Yen, H. W.
AU - Voon, W. C.
AU - Lai, W. T.
AU - Sheu, S. H.
DA - Jun
DO - 10.1016/j.jjcc.2014.07.014
DP - NLM
ET - 2014/08/27
IS - 6
KW - Aged
Atrial Fibrillation/complications/diagnostic imaging/*physiopathology
Cardiovascular Diseases/etiology/physiopathology
Echocardiography, Doppler/methods
Female
*Health Status Indicators
Heart Failure/etiology/physiopathology
Humans
Male
Middle Aged
Mitral Valve/physiopathology
Myocardial Contraction/physiology
Prognosis
Prospective Studies
Pulse Wave Analysis
Stroke/etiology/physiopathology
Stroke Volume/*physiology
Atrial fibrillation
Ejection time
Isovolumic relaxation time
Myocardial performance index
Pre-ejection period
LA - eng
N1 - 1876-4738
Chu, Chun-Yuan
Lee, Wen-Hsien
Hsu, Po-Chao
Lee, Hung-Hao
Chiu, Cheng-An
Su, Ho-Ming
Lin, Tsung-Hsien
Lee, Chee-Siong
Yen, Hsueh-Wei
Voon, Wen-Chol
Lai, Wen-Ter
Sheu, Sheng-Hsiung
Journal Article
Observational Study
Netherlands
J Cardiol. 2015 Jun;65(6):466-73. doi: 10.1016/j.jjcc.2014.07.014. Epub 2014 Aug
22.
PY - 2015
SN - 0914-5087
SP - 466-73
ST - Myocardial performance index derived from pre-ejection period as a novel and
useful predictor of cardiovascular events in atrial fibrillation
T2 - J Cardiol
TI - Myocardial performance index derived from pre-ejection period as a novel and
useful predictor of cardiovascular events in atrial fibrillation
VL - 65
ID - 2496
ER -
TY - JOUR
AB - OBJECTIVES: The presence of postoperative atrial fibrillation predicts a
higher short- and long-term mortality rates; however, no scoring system has been
used to discriminate patients at high risk for this complication. The aim of this
study was to investigate whether the CHADS2 and CHA2DS2-VASc scores are useful risk
assessment tools for new-onset atrial fibrillation after cardiac surgery. METHODS:
A total of 277 consecutive patients who underwent cardiac surgery were
prospectively included in this risk stratification study. We calculated the CHADS2
and CHA2DS2-VASc scores from the data collected. The primary end point was the
development of postoperative atrial fibrillation within 30 days after cardiac
surgery. RESULTS: Eighty-four (30%) of the patients had postoperative atrial
fibrillation at a median of 2 days (range, 0-27 days) after cardiac surgery. The
CHADS2 and CHA2DS2-VASc scores were significant predictors of postoperative atrial
fibrillation in separate multivariate regression analyses. The Kaplan-Meier
analysis obtained a higher postoperative atrial fibrillation rate when based on the
CHADS2 and CHA2DS2-VASc scores of at least 2 than when based on scores less than 2
(both log rank, P < .001). In addition, the CHA2DS2-VASc scores could be used to
further stratify the patients with CHADS2 scores of 0 or 1 into 2 groups with
different postoperative atrial fibrillation rates at a cutoff value of 2 (12% vs
32%; P = .01). CONCLUSIONS: CHADS2 and CHA2DS2-VASc scores were predictive of
postoperative atrial fibrillation after cardiac surgery and may be helpful for
identifying high-risk patients.
AD - Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical
University, Taipei, Taiwan; Division of Cardiology, Department of Internal
Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan; Department of
General Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
AN - 23628495
AU - Chua, S. K.
AU - Shyu, K. G.
AU - Lu, M. J.
AU - Lien, L. M.
AU - Lin, C. H.
AU - Chao, H. H.
AU - Lo, H. M.
DA - Oct
DO - 10.1016/j.jtcvs.2013.03.040
DP - NLM
ET - 2013/05/01
IS - 4
KW - Aged
Atrial Fibrillation/diagnosis/*etiology
*Decision Support Techniques
Female
Humans
Logistic Models
Male
Middle Aged
Odds Ratio
Patient Selection
Prospective Studies
Risk Assessment
Risk Factors
Time Factors
Treatment Outcome
23.1
24
Af
Cabg
Ci
E
Lv
Lvedd
Lvm
Or
Pad
Poaf
Pwtd
Swtd
Tia
atrial fibrillation
confidence interval
coronary artery bypass grafting
early mitral inflow velocity
e′
interventricular septal wall thickness
left ventricular
left ventricular end-diastolic diameter
left ventricular mass
medial mitral annular velocity during passive filling
peripheral arterial disease
posterior wall thickness
postoperative atrial fibrillation
transient ischemic attack
LA - eng
N1 - 1097-685x
Chua, Su-Kiat
Shyu, Kou-Gi
Lu, Ming-Jen
Lien, Li-Ming
Lin, Chia-Hsun
Chao, Hung-Hsing
Lo, Huey-Ming
Comparative Study
Journal Article
United States
J Thorac Cardiovasc Surg. 2013 Oct;146(4):919-926.e1. doi:
10.1016/j.jtcvs.2013.03.040. Epub 2013 Apr 26.
PY - 2013
SN - 0022-5223
SP - 919-926.e1
ST - Clinical utility of CHADS2 and CHA2DS2-VASc scoring systems for predicting
postoperative atrial fibrillation after cardiac surgery
TI - Clinical utility of CHADS2 and CHA2DS2-VASc scoring systems for predicting
postoperative atrial fibrillation after cardiac surgery
VL - 146
ID - 2955
ER -
TY - JOUR
AB - The risk stratification of patients with coexisting non valvular atrial
fibrillation and congestive heart failure, is often a clinical challenge, as the
definitions of congestive heart failure in the popular CHADS2 and CHA2DS2VASc
scoring systems, and amongst major clinical trials on Warfarin and Novel Oral
Anticoagulants (NOAC) have heterogeneity. Available evidence reveals that any heart
failure and/or left ventricular systolic dysfunction is associated with higher
rates of stroke/systemic embolism and bleeding in patients with non valvular atrial
fibrillation compared to patients without heart failure and normal left ventricular
function. Most standard dose NOAC regimens have a better safety and efficacy
profile over warfarin in most heart failure sub-group types with a few exceptions
including patients with NYHA III/IV on Dabigatran 150mg BID from the RE-LY trial,
who had higher major bleeding events, and patients with asymptomatic left
ventricular dysfunction (ejection fraction ≤40%) and heart failure with reduced
ejection fraction on 20mg of Rivaroxaban in the ROCKET-AF trial, when compared to
patients on Warfarin in the corresponding groups. With the gaining popularity and
use of NOACs, understanding their safety profile in such situations is paramount.
AD - Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY, United
States. Electronic address: yashasvichugh@hotmail.com.
Albert Einstein College of Medicine, Chair of Medicine, North Bronx Healthcare
Network (Jacobi Medical Center and North Central Bronx Hospital), Bronx, NY, United
States.
AN - 27693993
AU - Chugh, Y.
AU - Faillace, R. T.
DA - Dec 1
DO - 10.1016/j.ijcard.2016.09.025
DP - NLM
ET - 2016/10/25
KW - *Anticoagulants/classification/therapeutic use
*Atrial Fibrillation/complications/drug therapy/epidemiology
Comorbidity
*Heart Failure/epidemiology/physiopathology
*Hemorrhage/chemically induced/prevention & control
Humans
Research Design
Risk Adjustment/*methods
Risk Factors
*Stroke/etiology/prevention & control
Stroke Volume
LA - eng
N1 - 1874-1754
Chugh, Y
Faillace, R T
Editorial
Netherlands
Int J Cardiol. 2016 Dec 1;224:431-436. doi: 10.1016/j.ijcard.2016.09.025. Epub 2016
Sep 17.
PY - 2016
SN - 0167-5273
SP - 431-436
ST - The C of CHADS: Historical perspective and clinical applications for
anticoagulation in patients with non valvular atrial fibrillation and congestive
heart failure
T2 - Int J Cardiol
TI - The C of CHADS: Historical perspective and clinical applications for
anticoagulation in patients with non valvular atrial fibrillation and congestive
heart failure
VL - 224
ID - 2517
ER -
TY - JOUR
AB - Cancer survival continues to improve, and thus cardiovascular consequences of
chemotherapy are increasingly important determinants of long-term morbidity and
mortality. Conventional strategies to protect the heart from chemotherapy have
important hemodynamic or myelosuppressive side effects. Remote ischemic
conditioning (RIC) using intermittent limb ischemia-reperfusion reduces myocardial
injury in the setting of percutaneous coronary intervention. Anthracycline
cardiotoxicity and ischemia-reperfusion injury share common biochemical pathways in
cardiomyocytes. The potential for RIC as a novel treatment to reduce subclinical
myocyte injury in chemotherapy has never been explored and will be investigated in
the Effect of Remote Ischaemic Conditioning in Oncology (ERIC-ONC) trial
(clinicaltrials.gov NCT 02471885). The ERIC-ONC trial is a single-center, blinded,
randomized, sham-controlled study. We aim to recruit 128 adult oncology patients
undergoing anthracycline-based chemotherapy treatment, randomized in a 1:1 ratio
into 2 groups: (1) sham procedure or (2) RIC, comprising 4, 5-minute cycles of
upper arm blood pressure cuff inflations and deflations, immediately before each
cycle of chemotherapy. The primary outcome measure, defining cardiac injury, will
be high-sensitivity troponin-T over 6 cycles of chemotherapy and 12 months follow-
up. Secondary outcome measures will include clinical, electrical, structural, and
biochemical endpoints comprising major adverse cardiovascular clinical events,
incidence of cardiac arrhythmia over 14 days at cycle 5/6, echocardiographic
ventricular function, N-terminal pro-brain natriuretic peptide levels at 3 months
follow-up, and changes in mitochondrial DNA, micro-RNA, and proteomics after
chemotherapy. The ERIC-ONC trial will determine the efficacy of RIC as a novel,
noninvasive, nonpharmacological, low-cost cardioprotectant in cancer patients
undergoing anthracycline-based chemotherapy.
AD - The Hatter Cardiovascular Institute, University College London, London,
United Kingdom.
Research Department of Oncology, The Cancer Institute, University College London,
London, United Kingdom.
Cardiovascular and Metabolic Disorders Program, Duke University-National University
of Singapore Medical School, Singapore.
AN - 26807534
AU - Chung, R.
AU - Maulik, A.
AU - Hamarneh, A.
AU - Hochhauser, D.
AU - Hausenloy, D. J.
AU - Walker, J. M.
AU - Yellon, D. M.
C2 - PMC4864751
DA - Feb
DO - 10.1002/clc.22507
DP - NLM
ET - 2016/01/26
IS - 2
KW - Anthracyclines/*adverse effects
Antibiotics, Antineoplastic/*adverse effects
Cardiotoxicity
Clinical Protocols
Heart Diseases/chemically induced/diagnosis/*prevention & control
Humans
Ischemic Preconditioning/*methods
London
Neoplasms/diagnosis/*drug therapy
Regional Blood Flow
Research Design
Single-Blind Method
Time Factors
Treatment Outcome
Upper Extremity/*blood supply
LA - eng
N1 - 1932-8737
Chung, Robin
Maulik, Angshuman
Hamarneh, Ashraf
Hochhauser, Daniel
Hausenloy, Derek J
Walker, J Malcolm
Yellon, Derek M
Journal Article
Clin Cardiol. 2016 Feb;39(2):72-82. doi: 10.1002/clc.22507. Epub 2016 Jan 25.
PY - 2016
SN - 0160-9289 (Print)
0160-9289
SP - 72-82
ST - Effect of Remote Ischaemic Conditioning in Oncology Patients Undergoing
Chemotherapy: Rationale and Design of the ERIC-ONC Study--A Single-Center, Blinded,
T2 - Clin Cardiol
TI - Effect of Remote Ischaemic Conditioning in Oncology Patients Undergoing
Chemotherapy: Rationale and Design of the ERIC-ONC Study--A Single-Center, Blinded,
VL - 39
ID - 3123
ER -
TY - JOUR
AB - It is unknown whether heart failure (HF) with preserved ejection fraction
(HFpEF) and HF with reduced ejection fraction (HFrEF) carry a similar risk of
stroke or systemic embolism (SE) and other outcomes in patients with nonvalvular
atrial fibrillation (AF). A prospective, multicenter outpatient registry with
echocardiographic data which enrolled 10,589 patients from June 2016 to May 2019
was analyzed. In this registry, 935 (8.8%) patients had HF, and the proportions of
patients with HFpEF and HFrEF were 43.2% and 56.8%, respectively. During follow-up
over 1.33 years, 11 (2.07 per 100 person-years [PYR]) and 5 (0.76 per 100 PYR)
patients had stroke/SE in the HFpEF and HFrEF groups, respectively, whereas 102
patients (0.84 per 100 PYR) had these sequelae in the no-HF group. The HFpEF group
had a significantly higher cumulative incidence of stroke/SE (p = 0.004) and risk
of stroke/SE (adjusted hazard ratio [HR] 2.23, 95% confidence interval [CI] 1.19 to
4.18) than the no-HF group. The risk of stroke/SE in the HFpEF group compared with
that in the no-HF group was consistently increased even in patients on oral
anticoagulation therapy (adjusted HR 2.55, 95% CI 1.31 to 4.96). There was a
correlation between larger left atrial size and risk of stroke/SE (adjusted HR
1.53, 95% CI 1.03 to 2.29), but not between reduced left ventricular ejection
fraction and this risk. In conclusion, these results suggest that strict oral
anticoagulation therapy helps reduce the risk of stroke/SE in patients with
nonvalvular AF and HFpEF, especially in those with a larger left atrial size.
AD - Division of Cardiology, Department of Internal Medicine, Severance
Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of
Korea.
Department of Internal Medicine, Seoul National University Hospital, Seoul,
Republic of Korea.
Division of Cardiology, Department of Internal Medicine, Kyung Hee University
Hospital, Kyung Hee University, Seoul, Republic of Korea.
Department of Cardiology, School of Medicine, Ewha Woman`s University, Seoul,
Republic of Korea.
Department of Cardiology, Hanyang University Seoul Hospital, Seoul, Republic of
Korea.
Division of Cardiology, Eulji University Hospital, Daejeon, Republic of Korea.
Heart Institute, Asan Medical Center, University of Ulsan College of Medicine,
Seoul, Republic of Korea.
Department of Cardiology, Chonnam National University Hospital, Chonnam National
University School of Medicine, Gwangju, Republic of Korea.
Department of Preventive Medicine, Yonsei University College of Medicine, Seoul,
Republic of Korea.
Division of Cardiology, Department of Internal Medicine, Daegu Catholic University
Medical Center, Daegu, Republic of Korea.
Division of Cardiology, Department of Internal Medicine, Korea University Medical
Center, Seoul, Republic of Korea.
Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular
Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Electronic address: cby6908@yuhs.ac.
AN - 31699363
AU - Chung, S.
AU - Kim, T. H.
AU - Uhm, J. S.
AU - Cha, M. J.
AU - Lee, J. M.
AU - Park, J.
AU - Park, J. K.
AU - Kang, K. W.
AU - Kim, J.
AU - Park, H. W.
AU - Choi, E. K.
AU - Kim, J. B.
AU - Kim, C. S.
AU - Lee, Y. S.
AU - Shim, J.
AU - Joung, B.
DA - Jan 1
DO - 10.1016/j.amjcard.2019.09.035
DP - NLM
ET - 2019/11/09
IS - 1
Aged
Anticoagulants/*administration & dosage
Atrial Fibrillation/*complications/diagnosis/drug therapy
Echocardiography
Embolism/epidemiology/*etiology/prevention & control
Female
Follow-Up Studies
Heart Failure/*complications/drug therapy/physiopathology
Heart Ventricles/diagnostic imaging/physiopathology
Humans
Incidence
Male
Middle Aged
Prognosis
Prospective Studies
Republic of Korea/epidemiology
Risk Factors
LA - eng
N1 - 1879-1913
Chung, Seyong
Kim, Tae-Hoon
Uhm, Jae-Sun
Cha, Myung-Jin
Lee, Jung-Myung
Park, Junbeom
Park, Jin-Kyu
Kang, Ki-Woon
Kim, Jun
Park, Hyung Wook
Choi, Eue-Keun
Kim, Jin-Bae
Kim, Chang-Soo
Lee, Young Soo
Shim, Jaemin
Joung, Boyoung
Comparative Study
Journal Article
Multicenter Study
United States
Am J Cardiol. 2020 Jan 1;125(1):68-75. doi: 10.1016/j.amjcard.2019.09.035. Epub
2019 Oct 10.
PY - 2020
SN - 0002-9149
SP - 68-75
ST - Stroke and Systemic Embolism and Other Adverse Outcomes of Heart Failure With
Preserved and Reduced Ejection Fraction in Patients With Atrial Fibrillation (from
the COmparison study of Drugs for symptom control and complication prEvention of
Atrial Fibrillation [CODE-AF])
T2 - Am J Cardiol
TI - Stroke and Systemic Embolism and Other Adverse Outcomes of Heart Failure With
Preserved and Reduced Ejection Fraction in Patients With Atrial Fibrillation (from
the COmparison study of Drugs for symptom control and complication prEvention of
Atrial Fibrillation [CODE-AF])
VL - 125
ID - 2335
ER -
TY - JOUR
AB - BACKGROUND: The risk factors involved in the onset of atrial fibrillation
(AF) are well known, but the predictive clinical and paraclinical parameters for
the onset of AF in hypertensive patients have not been investigated specifically.
METHODS AND RESULTS: We retrospectively analyzed 97 consecutive patients with
hypertension and no known history of AF or cardiovascular events who attended the
cardiology outpatient clinic. The analysis was based on clinical data, the
noninvasive ambulatory 24-hour measurement of blood pressure (AMBP), a standard 12-
lead electrocardiogram, and a Doppler echocardiogram. After a mean follow-up of 25
+/- 3 months, 19 (19. 5%) patients had AF, 3 (15.8%) of whom had a cerebrovascular
accident. The patients with AF were older than the others and their AMBP showed
higher mean systolic diurnal and nocturnal blood pressures, though no differences
in the clinical blood pressure readings were present. On the electrocardiogram, the
maximum duration of the P wave and its dispersion were more prolonged in the
patients with AF. On the Doppler echocardiogram, left ventricular mass and left
atrial dimension were higher in the patients with AF, and the A-wave velocity of
diastolic mitral flow was reduced in these patients. In the multivariate analysis,
age (odds ratio 3.28, P <.001), diurnal systolic blood pressure (odds ratio 1.35, P
<.01) and nocturnal systolic blood pressure (odds ratio 1.16, P <.01), maximum
duration of the P wave (odds ratio 2.09, P <.01), dispersion of the P wave (odds
ratio 2.52, P <.001), echocardiographic left ventricular mass (odds ratio 1.43, P
<.01), left atrial dimension (odds ratio 2.81, P <.001), and velocity of the A wave
(odds ratio 2. 24, P <.01) were independent predictors for the onset of AF. After
correction for age, maximum duration of the P wave (odds ratio 1.34, P <.01),
dispersion of the P wave (odds ratio 1.63, P <.001), and the velocity of the A wave
(odds ratio 1.42, P <.01) remained independent predictors for the onset of AF.
CONCLUSIONS: In patients with hypertension, age and the level of diurnal and
nocturnal systolic blood pressures measured by 24-hour AMBP are important
independent predictors for the onset of AF. Independent of age, increases in left
atrial dimension and left ventricular mass, prolongation of the maximum duration
and dispersion of the P wave and reduced A-wave velocity are also predictors for
the onset of AF.
AD - Cardiology Unit, Medical/Surgical Cardiovascular Department, Hôpital de la
Tour, Meyrin-Geneva, Switzerland.
AN - 10783214
AU - Ciaroni, S.
AU - Cuenoud, L.
AU - Bloch, A.
DA - May
DO - 10.1016/s0002-8703(00)90012-7
DP - NLM
ET - 2000/04/27
IS - 5
KW - Age Factors
Aged
Atrial Fibrillation/*diagnosis/physiopathology
Blood Pressure/physiology
Blood Pressure Monitors
Circadian Rhythm/physiology
Echocardiography, Doppler
Female
Follow-Up Studies
Humans
Hypertension/*diagnosis/physiopathology
Male
Middle Aged
Risk Factors
Stroke/diagnosis/physiopathology
Systole/physiology
LA - eng
N1 - Ciaroni, S
Cuenoud, L
Bloch, A
Journal Article
United States
Am Heart J. 2000 May;139(5):814-9. doi: 10.1016/s0002-8703(00)90012-7.
PY - 2000
SN - 0002-8703 (Print)
0002-8703
SP - 814-9
ST - Clinical study to investigate the predictive parameters for the onset of
atrial fibrillation in patients with essential hypertension
T2 - Am Heart J
TI - Clinical study to investigate the predictive parameters for the onset of
atrial fibrillation in patients with essential hypertension
VL - 139
ID - 2646
ER -
TY - JOUR
AB - BACKGROUND: Patients with severe aortic stenosis and reduced left ventricular
ejection fraction (LVEF) have a poor prognosis with conservative therapy but a high
operative mortality when treated surgically. Recently, transcatheter aortic valve
implantation (TAVI) has emerged as an alternative to surgical aortic valve
replacement (SAVR) for patients considered at high or prohibitive operative risk.
The objective of this study was to compare TAVI and SAVR with respect to
postoperative recovery of LVEF in patients with severe aortic stenosis and reduced
LV systolic function. METHODS AND RESULTS: Echocardiographic data were
prospectively collected before and after the procedure in 200 patients undergoing
SAVR and 83 patients undergoing TAVI for severe aortic stenosis (aortic valve area
≤1 cm(2)) with reduced LV systolic function (LVEF ≤50%). TAVI patients were
significantly older (81±8 versus 70±10 years; P<0.0001) and had more comorbidities
compared with SAVR patients. Despite similar baseline LVEF (34±11% versus 34±10%),
TAVI patients had better recovery of LVEF compared with SAVR patients (ΔLVEF,
14±15% versus 7±11%; P=0.005). At the 1-year follow-up, 58% of TAVI patients had a
normalization of LVEF (>50%) as opposed to 20% in the SAVR group. On multivariable
analysis, female gender (P=0.004), lower LVEF at baseline (P=0.005), absence of
atrial fibrillation (P=0.01), TAVI (P=0.007), and larger increase in aortic valve
area after the procedure (P=0.01) were independently associated with better
recovery of LVEF. CONCLUSION: In patients with severe aortic stenosis and depressed
LV systolic function, TAVI is associated with better LVEF recovery compared with
SAVR. TAVI may provide an interesting alternative to SAVR in patients with
depressed LV systolic function considered at high surgical risk.
AD - Institut Universitaire de Cardiologie et de Pneumologie de Québec/Québec
Heart and Lung Institute, Laval University, Québec, Canada.
AN - 20975002
AU - Clavel, M. A.
AU - Webb, J. G.
AU - Rodés-Cabau, J.
AU - Masson, J. B.
AU - Dumont, E.
AU - De Larochellière, R.
AU - Doyle, D.
AU - Bergeron, S.
AU - Baumgartner, H.
AU - Burwash, I. G.
AU - Dumesnil, J. G.
AU - Mundigler, G.
AU - Moss, R.
AU - Kempny, A.
AU - Bagur, R.
AU - Bergler-Klein, J.
AU - Gurvitch, R.
AU - Mathieu, P.
AU - Pibarot, P.
DA - Nov 9
DP - NLM
ET - 2010/10/27
IS - 19
J2 - Circulation
KW - Aged
Aged, 80 and over
Aortic Valve/transplantation
Aortic Valve Stenosis/diagnostic imaging/mortality/physiopathology/*surgery
Atrial Fibrillation/diagnostic imaging/mortality/physiopathology/surgery
Bioprosthesis
Female
Heart Valve Prosthesis Implantation/*methods/mortality
Humans
Male
Middle Aged
Mitral Valve Insufficiency/diagnostic imaging/mortality/physiopathology/surgery
Myocardial Infarction/complications/epidemiology
Sex Characteristics
Treatment Outcome
LA - eng
N1 - 1524-4539
Clavel, M A
Webb, J G
Rodés-Cabau, J
Masson, J B
Dumont, E
De Larochellière, R
Doyle, D
Bergeron, S
Baumgartner, H
Burwash, I G
Dumesnil, J G
Mundigler, G
Moss, R
Kempny, A
Bagur, R
Bergler-Klein, J
Gurvitch, R
Mathieu, P
Pibarot, P
Journal Article
United States
Circulation. 2010 Nov 9;122(19):1928-36. doi: 10.1161/CIRCULATIONAHA.109.929893.
Epub 2010 Oct 25.
PY - 2010
SN - 0009-7322
SP - 1928-36
ST - Comparison between transcatheter and surgical prosthetic valve implantation
in patients with severe aortic stenosis and reduced left ventricular ejection
fraction
T2 - Circulation
TI - Comparison between transcatheter and surgical prosthetic valve implantation
in patients with severe aortic stenosis and reduced left ventricular ejection
fraction
VL - 122
ID - 2589
ER -
TY - JOUR
AB - Stroke is the leading cause of mortality in women in Spain. RIMHA is a cross-
sectional multicenter study in hypertensive women aged 55 or more in primary care
to estimate the 10-year risk for a first stroke. Clinical history, cardiovascular
risk factors and diseases, electrocardiogram, blood samples and blood pressure (BP)
were recorded. Stroke and coronary risk were estimated using the appropriate
Framingham scales; 12875 patients were included (mean age 68.0+/-8.5 years, 29.1%
with diabetes, 19.7% with cardiovascular disease). Electrocardiographic left
ventricular hypertrophy (LVH) was present in 19.2% BP was controlled in 42.9% of
non-diabetic (BP<140/90 mmHg) and 9.7% of diabetic patients (BP<130/80 mmHg). The
10-year risk (+/- SD) for a first stroke was estimated as 15.8+/-16.3%, and the
coronary risk as 12.0+/-6.3. In the multivariate analysis, the most contributing
factors for stroke risk estimation were age, systolic BP, LVH and atrial
fibrillation. In conclusion, the 10-year estimated stroke risk for Spanish
hypertensive women aged 55 years or more was higher than the estimated coronary
risk, in accordance with the high rates of morbidity and mortality due to stroke
among women in Spain. The most powerful risk factors were older age, poor BP
control, LVH and atrial fibrillation.
AD - Hypertension Unit, Hospital Clinic (IDIBAPS), University of Barcelona, Spain.
acoca@clinic.ub.es
AN - 17078178
AU - Coca, A.
AU - Redón, J.
AU - Cea-Calvo, L.
AU - Lozano, J. V.
AU - Navarro, J.
AU - Fernández-Pérez, C.
AU - Bonet, A.
AU - González-Esteban, J.
DO - 10.1080/08037050600913474
DP - NLM
ET - 2006/11/03
IS - 4
J2 - Blood pressure
KW - Age Factors
Aged
Blood Pressure/*drug effects
Coronary Disease/*etiology
Female
Humans
Hypertension/*complications/epidemiology
Linear Models
Middle Aged
Odds Ratio
Risk Factors
Spain/epidemiology
Stroke/*etiology
LA - eng
N1 - Coca, Antonio
Redón, Josep
Cea-Calvo, Luis
Lozano, José V
Navarro, Jorge
Fernández-Pérez, Cristina
Bonet, Alvaro
González-Esteban, Jorge
Investigators of the RIMH Study
Journal Article
Multicenter Study
England
Blood Press. 2006;15(4):237-44. doi: 10.1080/08037050600913474.
PY - 2006
SN - 0803-7051 (Print)
0803-7051
SP - 237-44
ST - Estimated risk of a first stroke and conditioning factors in Spanish
hypertensive women. The RIMH study
T2 - Blood Press
TI - Estimated risk of a first stroke and conditioning factors in Spanish
hypertensive women. The RIMH study
VL - 15
ID - 2785
ER -
TY - JOUR
AB - Interatrial communications (ICs) have been linked to paradoxic embolism,
which may be prevented using both surgical and percutaneous interventions. The case
of a 61-year-old woman with a history of transient cerebral ischemic attack who
developed repetitive ventricular arrhythmias and an intermittent left branch bundle
block immediately after percutaneous closure of an IC is described. Transthoracic
echocardiography showed that the device had migrated into the left ventricular
outflow tract, and the patient consequently underwent emergency cardiac surgery to
retrieve the device and repair the IC. In conclusion, percutaneous transcatheter
closure of ICs is more rapid and less invasive compared with surgery, but
nevertheless may be associated with significant short-term morbidity.
AD - Cardiac and Thoracic Department, University of Pisa, Pisa, Italy.
AN - 17884385
AU - Coceani, M.
AU - Zucchelli, G.
AU - Bongiorni, M. G.
AU - Di Cori, A.
AU - Petronio, A. S.
AU - Ciabatti, N.
AU - Nardi, C.
AU - Barsotti, A.
DA - Oct 1
DO - 10.1016/j.amjcard.2007.04.062
DP - NLM
ET - 2007/09/22
IS - 7
KW - Bundle-Branch Block/diagnosis/*etiology
Cardiac Catheterization
Electrocardiography
Embolism, Paradoxical/complications
Female
Heart Septal Defects, Atrial/complications/diagnostic imaging/*surgery
Heart Septum/*surgery
Humans
Middle Aged
Prostheses and Implants/*adverse effects
Tachycardia, Ventricular/diagnosis/*etiology
Treatment Outcome
LA - eng
N1 - Coceani, Michele
Zucchelli, Giulio
Bongiorni, Maria Grazia
Di Cori, Andrea
Petronio, Anna Sonia
Ciabatti, Nicola
Nardi, Carmela
Barsotti, Antonio
Case Reports
Journal Article
United States
Am J Cardiol. 2007 Oct 1;100(7):1181-3. doi: 10.1016/j.amjcard.2007.04.062. Epub
2007 Jul 16.
PY - 2007
SN - 0002-9149 (Print)
0002-9149
SP - 1181-3
ST - An arrhythmic storm: a potential complication on opening the umbrella for
percutaneous closure of interatrial communications
T2 - Am J Cardiol
TI - An arrhythmic storm: a potential complication on opening the umbrella for
percutaneous closure of interatrial communications
VL - 100
ID - 2728
ER -
TY - JOUR
AB - Atrial fibrillation (AF) is the most common sustained arrhythmia. AF has now
been exhaustively studied: more is known about its mechanism and research is moving
towards new forms of treatment. For chronic AF, basically the control of
ventricular rate and the brain protection are the main issues. It is well known
that with the identification of high risk group for embolism, oral anticoagulation
should be administered. Ventricular rate control can be achieved by using
betablockers or calcium channel blockers, unless these are contraindicated for the
elderly. Oral anticoagulation prevents the stroke. The main mechanism of AF is the
re-entry of multiple wavelets, but now it is more frequently found on patients with
focal AF. Therapies are employed to bring the patient to a sinusal rhythm as soon
as possible with antiarryhthmics or electric cardioversion externally or
internally. The internal procedure includes 1 to 15 J and the success rate is of
91% vs 67% in relation to the external one. The introduction of the catheter
ablation has opened new frontiers for the treatment of AF, first as the ablate-and-
pace technique and now trying to mimic the maze procedure or with the ablation of
the focal tachycardia. The stimulation for prevention of AF under research, as well
as the implantable dysfibrillation for selected patients. On going studies will
show the possible benefit of this type of benefits.
AD - Departamento de Electrocardiografía y Arritmias, Instituto Nacional de
Cardiología Ignacio Chávez, INCICH, Juan Badiano No. 1, 14080 México, D.F.
AN - 11565343
AU - Colín Lizalde, L. J.
DA - Jan-Mar
DP - NLM
ET - 2001/09/22
J2 - Archivos de cardiologia de Mexico
KW - *Atrial Fibrillation/physiopathology/therapy
Humans
LA - spa
N1 - Colín Lizalde, L J
English Abstract
Journal Article
Mexico
Arch Cardiol Mex. 2001 Jan-Mar;71 Suppl 1:S36-9.
OP - Fibrilación atrial.
PY - 2001
SN - 1405-9940 (Print)
1665-1731
SP - S36-9
ST - [Atrial fibrillation]
T2 - Arch Cardiol Mex
TI - [Atrial fibrillation]
VL - 71 Suppl 1
ID - 2783
ER -
TY - JOUR
AB - BACKGROUND AND PURPOSE: Acute stroke is associated with impairment of cardiac
autonomic balance and increased incidence of arrhythmias. These abnormalities
appear more relevant in the case of involvement of the right insula in the infarct
area. The aim of this study was to assess the impact of right-sided insular damage,
cardiac autonomic derangement, and arrhythmias on clinical outcome after acute
ischemic stroke. METHODS: Holter monitoring for 24 hours was performed in 208
consecutive patients with first-ever acute ischemic stroke. Time- and frequency-
domain measures of heart rate variability and arrhythmias were considered in all
cases. All patients were followed for a 12-month period after the initial event.
RESULTS: During the 12-month follow-up period, 48 patients died (1-year probability
of death, 0.23; 95% CI, 0.17 to 0.30). Multivariate analysis demonstrated that age
(hazard ratio [HR], 1.06; 95% CI, 1.01 to 1.10; P=0.0087), stroke severity on
admission (HR, 1.25; 95% CI, 1.13 to 1.39; P=0.0001), presence of right-sided
insular damage (HR, 2.01; 95% CI, 1.13 to 1.39; P=0.0187), as well as lower values
of the SD of all normal-to-normal RR intervals (HR, 3.32; 95% CI, 1.67 to 6.24;
P=0.002), and presence of nonsustained ventricular tachycardia during Holter
monitoring (HR, 2.99; 95% CI, 1.58 to 5.67; P=0.0007) were independent predictors
of 1-year mortality. CONCLUSIONS: The integration of traditional risk stratifiers
with autonomic and arrhythmic markers, and the careful search for right-sided
insular involvement, may represent an effective approach for identification of
stroke patients at risk for early mortality.
AD - Cardiovascular Department, San Filippo Neri Hospital, Rome, Italy.
furcol@rdn.it
AN - 16020766
AU - Colivicchi, F.
AU - Bassi, A.
AU - Santini, M.
AU - Caltagirone, C.
DA - Aug
DO - 10.1161/01.STR.0000173400.19346.bd
DP - NLM
ET - 2005/07/16
IS - 8
J2 - Stroke
KW - Aged
Arrhythmias, Cardiac/*pathology
Cohort Studies
Electrocardiography, Ambulatory/methods
Female
Heart Rate
Humans
Male
Middle Aged
*Myocardial Ischemia
Platelet Aggregation Inhibitors/pharmacology
Prognosis
Prospective Studies
Risk
Stroke/*diagnosis/mortality/*pathology/therapy
Tachycardia, Ventricular/therapy
Time Factors
Treatment Outcome
LA - eng
N1 - 1524-4628
Colivicchi, Furio
Bassi, Andrea
Santini, Massimo
Caltagirone, Carlo
Journal Article
United States
Stroke. 2005 Aug;36(8):1710-5. doi: 10.1161/01.STR.0000173400.19346.bd. Epub 2005
Jul 14.
PY - 2005
SN - 0039-2499
SP - 1710-5
ST - Prognostic implications of right-sided insular damage, cardiac autonomic
derangement, and arrhythmias after acute ischemic stroke
T2 - Stroke
TI - Prognostic implications of right-sided insular damage, cardiac autonomic
derangement, and arrhythmias after acute ischemic stroke
VL - 36
ID - 2350
ER -
TY - JOUR
AB - STUDY OBJECTIVE: We determine the prevalence of stroke prophylaxis
prescription in emergency department (ED) patients with atrial fibrillation and the
factors associated with a lack of prescription of anticoagulation in high-risk
patients without contraindications. METHODS: This was a multicenter, observational,
cross-sectional study with prospective standardized data collection carried out in
124 Spanish EDs. Clinical variables, risk factors for stroke, type of prophylaxis
prescribed, and reasons for not prescribing anticoagulation in high-risk patients
(congestive heart failure/left ventricular dysfunction, hypertension, age >75
years, diabetes and previous stroke/transient ischemic attack/systemic embolism
[CHADS2] score ≥2 and the congestive heart failure/left ventricular dysfunction,
hypertension, age >75 years, diabetes, previous stroke/transient ischemic
attack/systemic embolism, vascular disease age 65 to 74 years and sex category
[CHA2DS2-VASc] score ≥2) without contraindications were collected. RESULTS: Of
3,276 patients enrolled, 71.5% were at high risk according to CHADS2; 89.7%
according to CHA2DS2-VASc. At discharge from the ED, 2,255 patients (68.8%) were
receiving anticoagulants, 1,691 of whom (75%) were high-risk patients. Of the 1,931
patients discharged home, anticoagulation was prescribed for 384 patients (19.9%)
de novo and for 932 patients (48.3%) previously receiving anticoagulation. The main
reasons for not prescribing anticoagulation to eligible patients were considering
antiplatelet therapy as adequate prophylaxis (33.1%), advanced age (15%), and
considering stroke risk as low (8.3%). Advanced age (odds ratio 0.46; 95%
confidence interval 0.30 to 0.69) and female sex (odds ratio 0.50; 95% confidence
interval 0.36 to 0.71) were significantly associated with the lack of prescription
of anticoagulation to eligible patients. CONCLUSION: In Spain, most patients with
atrial fibrillation treated in EDs who do not receive anticoagulation are at high
risk of stroke, with relevant differences with regard to the risk stratification
scheme used. Anticoagulation is underused, mainly because the risk of stroke is
underestimated by the treating physicians and the benefits of antiplatelets are
overrated, principally in female patients and the elderly. Efforts to increase the
prescription of anticoagulation in these patients appear warranted.
AD - Arrhythmia Division, Spanish Society of Emergency Medicine, Madrid, Spain;
Emergency Department, Unitat de Fibrillació Auricular, Hospital Clínic, Barcelona,
and Grup de Recerca "Urgències: processos i patologies," IDIBAPS, Barcelona, Spain.
Electronic address: bcvinent@clinic.cat.
Arrhythmia Division, Spanish Society of Emergency Medicine, Madrid, Spain;
Emergency Department, Hospital Universitario Severo Ochoa and University Alfonso X,
Madrid, Spain.
Emergency Department, Hospital Universitario Torrejón, Madrid, Spain.
Emergency Department, Hospital Universitario Carlos Haya, Málaga, Spain.
Emergency Department, Hospital Universitario Virgen de las Nieves, Granada, Spain.
Emergency Department, Hospital de Basurto, Bilbao, Spain.
Emergency Department, Hospital Donostia, San Sebastián, Spain.
Emergency Department, Hospital Universitario Río Hortega, Valladolid, Spain.
Sanofi-Aventis Spain, Barcelona, Spain.
Emergency Department, Hospital Universitario La Princesa and Universidad Autónoma,
Madrid, Spain.
AN - 25182543
AU - Coll-Vinent, B.
AU - Martín, A.
AU - Malagón, F.
AU - Suero, C.
AU - Sánchez, J.
AU - Varona, M.
AU - Cancio, M.
AU - Sánchez, S.
AU - Montull, E.
AU - Del Arco, C.
DA - Jan
DO - 10.1016/j.annemergmed.2014.07.016
DP - NLM
ET - 2014/09/04
IS - 1
J2 - Annals of emergency medicine
KW - Age Factors
Aged
*Emergency Service, Hospital/statistics & numerical data
Female
Humans
Male
Practice Patterns, Physicians'/statistics & numerical data
Risk Assessment
Risk Factors
Sex Factors
Spain/epidemiology
LA - eng
N1 - 1097-6760
Coll-Vinent, Blanca
Martín, Alfonso
Malagón, Francisco
Suero, Coral
Sánchez, Juan
Varona, Mercedes
Cancio, Manuel
Sánchez, Susana
Montull, Eugeni
Del Arco, Carmen
HERMES-AF Investigators
Journal Article
Multicenter Study
Observational Study
United States
Ann Emerg Med. 2015 Jan;65(1):1-12. doi: 10.1016/j.annemergmed.2014.07.016. Epub
2014 Aug 30.
PY - 2015
SN - 0196-0644
SP - 1-12
ST - Stroke prophylaxis in atrial fibrillation: searching for management
improvement opportunities in the emergency department: the HERMES-AF study
T2 - Ann Emerg Med
TI - Stroke prophylaxis in atrial fibrillation: searching for management
improvement opportunities in the emergency department: the HERMES-AF study
VL - 65
ID - 2543
ER -
TY - JOUR
AB - BACKGROUND: Dronedarone restores sinus rhythm and reduces hospitalization or
death in intermittent atrial fibrillation. It also lowers heart rate and blood
pressure and has antiadrenergic and potential ventricular antiarrhythmic effects.
We hypothesized that dronedarone would reduce major vascular events in high-risk
permanent atrial fibrillation. METHODS: We assigned patients who were at least 65
years of age with at least a 6-month history of permanent atrial fibrillation and
risk factors for major vascular events to receive dronedarone or placebo. The first
coprimary outcome was stroke, myocardial infarction, systemic embolism, or death
from cardiovascular causes. The second coprimary outcome was unplanned
hospitalization for a cardiovascular cause or death. RESULTS: After the enrollment
of 3236 patients, the study was stopped for safety reasons. The first coprimary
outcome occurred in 43 patients receiving dronedarone and 19 receiving placebo
(hazard ratio, 2.29; 95% confidence interval [CI], 1.34 to 3.94; P=0.002). There
were 21 deaths from cardiovascular causes in the dronedarone group and 10 in the
placebo group (hazard ratio, 2.11; 95% CI, 1.00 to 4.49; P=0.046), including death
from arrhythmia in 13 patients and 4 patients, respectively (hazard ratio, 3.26;
95% CI, 1.06 to 10.00; P=0.03). Stroke occurred in 23 patients in the dronedarone
group and 10 in the placebo group (hazard ratio, 2.32; 95% CI, 1.11 to 4.88;
P=0.02). Hospitalization for heart failure occurred in 43 patients in the
dronedarone group and 24 in the placebo group (hazard ratio, 1.81; 95% CI, 1.10 to
2.99; P=0.02). CONCLUSIONS: Dronedarone increased rates of heart failure, stroke,
and death from cardiovascular causes in patients with permanent atrial fibrillation
who were at risk for major vascular events. Our data show that this drug should not
be used in such patients. (Funded by Sanofi-Aventis; PALLAS ClinicalTrials.gov
number, NCT01151137.).
AD - Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON
L8L 2X2, Canada. connostu@phri.ca
AN - 22082198
AU - Connolly, S. J.
AU - Camm, A. J.
AU - Halperin, J. L.
AU - Joyner, C.
AU - Alings, M.
AU - Amerena, J.
AU - Atar, D.
AU - Avezum, Á
AU - Blomström, P.
AU - Borggrefe, M.
AU - Budaj, A.
AU - Chen, S. A.
AU - Ching, C. K.
AU - Commerford, P.
AU - Dans, A.
AU - Davy, J. M.
AU - Delacrétaz, E.
AU - Di Pasquale, G.
AU - Diaz, R.
AU - Dorian, P.
AU - Flaker, G.
AU - Golitsyn, S.
AU - Gonzalez-Hermosillo, A.
AU - Granger, C. B.
AU - Heidbüchel, H.
AU - Kautzner, J.
AU - Kim, J. S.
AU - Lanas, F.
AU - Lewis, B. S.
AU - Merino, J. L.
AU - Morillo, C.
AU - Murin, J.
AU - Narasimhan, C.
AU - Paolasso, E.
AU - Parkhomenko, A.
AU - Peters, N. S.
AU - Sim, K. H.
AU - Stiles, M. K.
AU - Tanomsup, S.
AU - Toivonen, L.
AU - Tomcsányi, J.
AU - Torp-Pedersen, C.
AU - Tse, H. F.
AU - Vardas, P.
AU - Vinereanu, D.
AU - Xavier, D.
AU - Zhu, J.
AU - Zhu, J. R.
AU - Baret-Cormel, L.
AU - Weinling, E.
AU - Staiger, C.
AU - Yusuf, S.
AU - Chrolavicius, S.
AU - Afzal, R.
AU - Hohnloser, S. H.
DA - Dec 15
DO - 10.1056/NEJMoa1109867
DP - NLM
ET - 2011/11/16
IS - 24
KW - Aged
Aged, 80 and over
Amiodarone/adverse effects/*analogs & derivatives/therapeutic use
Anti-Arrhythmia Agents/adverse effects/blood/*therapeutic use
Atrial Fibrillation/blood/*drug therapy
Atrial Flutter/drug therapy
Cardiovascular Diseases/chemically induced/mortality
Chronic Disease
Digoxin/blood/therapeutic use
Double-Blind Method
Dronedarone
Drug Therapy, Combination
Female
Follow-Up Studies
Heart Failure/chemically induced/epidemiology
Humans
Male
Risk Factors
Stroke/chemically induced/epidemiology
LA - eng
N1 - 1533-4406
Connolly, Stuart J
Camm, A John
Halperin, Jonathan L
Joyner, Campbell
Alings, Marco
Amerena, John
Atar, Dan
Avezum, Álvaro
Blomström, Per
Borggrefe, Martin
Budaj, Andrzej
Chen, Shih-Ann
Ching, Chi Keong
Commerford, Patrick
Dans, Antonio
Davy, Jean-Marc
Delacrétaz, Etienne
Di Pasquale, Giuseppe
Diaz, Rafael
Dorian, Paul
Flaker, Greg
Golitsyn, Sergey
Gonzalez-Hermosillo, Antonio
Granger, Christopher B
Heidbüchel, Hein
Kautzner, Josef
Kim, June Soo
Lanas, Fernando
Lewis, Basil S
Merino, Jose L
Morillo, Carlos
Murin, Jan
Narasimhan, Calambur
Paolasso, Ernesto
Parkhomenko, Alexander
Peters, Nicholas S
Sim, Kui-Hian
Stiles, Martin K
Tanomsup, Supachai
Toivonen, Lauri
Tomcsányi, János
Torp-Pedersen, Christian
Tse, Hung-Fat
Vardas, Panos
Vinereanu, Dragos
Xavier, Denis
Zhu, Jun
Zhu, Jun-Ren
Baret-Cormel, Lydie
Weinling, Estelle
Staiger, Christoph
Yusuf, Salim
Chrolavicius, Susan
Afzal, Rizwan
Hohnloser, Stefan H
PALLAS Investigators
RG/10/11/28457/British Heart Foundation/United Kingdom
Journal Article
Multicenter Study
United States
N Engl J Med. 2011 Dec 15;365(24):2268-76. doi: 10.1056/NEJMoa1109867. Epub 2011
Nov 14.
PY - 2011
SN - 0028-4793
SP - 2268-76
ST - Dronedarone in high-risk permanent atrial fibrillation
T2 - N Engl J Med
TI - Dronedarone in high-risk permanent atrial fibrillation
VL - 365
ID - 2291
ER -
TY - JOUR
AB - BACKGROUND: Evidence suggests that physiologic pacing (dual-chamber or
atrial) may be superior to single-chamber (ventricular) pacing because it is
associated with lower risks of atrial fibrillation, stroke, and death. These
benefits have not been evaluated in a large, randomized, controlled trial. METHODS:
At 32 Canadian centers, patients without chronic atrial fibrillation who were
scheduled for a first implantation of a pacemaker to treat symptomatic bradycardia
were eligible for enrollment. We randomly assigned patients to receive either a
ventricular pacemaker or a physiologic pacemaker and followed them for an average
of three years. The primary outcome was stroke or death due to cardiovascular
causes. Secondary outcomes were death from any cause, atrial fibrillation, and
hospitalization for heart failure. RESULTS: A total of 1474 patients were randomly
assigned to receive a ventricular pacemaker and 1094 to receive a physiologic
pacemaker. The annual rate of stroke or death due to cardiovascular causes was 5.5
percent with ventricular pacing, as compared with 4.9 percent with physiologic
pacing (reduction in relative risk, 9.4 percent; 95 percent confidence interval,
-10.5 to 25.7 percent [the negative value indicates an increase in risk]; P=0.33).
The annual rate of atrial fibrillation was significantly lower among the patients
in the physiologic-pacing group (5.3 percent) than among those in the ventricular-
pacing group (6.6 percent), for a reduction in relative risk of 18.0 percent (95
percent confidence interval, 0.3 to 32.6 percent; P=0.05). The effect on the rate
of atrial fibrillation was not apparent until two years after implantation. The
observed annual rates of death from all causes and of hospitalization for heart
failure were lower among the patients with a physiologic pacemaker than among those
with a ventricular pacemaker, but not significantly so (annual rates of death, 6.6
percent with ventricular pacing and 6.3 percent with physiologic pacing; annual
rates of hospitalization for heart failure, 3.5 percent and 3.1 percent,
respectively). There were significantly more perioperative complications with
physiologic pacing than with ventricular pacing (9.0 percent vs. 3.8 percent,
P<0.001). CONCLUSIONS: Physiologic pacing provides little benefit over ventricular
pacing for the prevention of stroke or death due to cardiovascular causes.
AD - Department of Medicine, McMaster University, Hamilton, Ont, Canada.
connostu@hhsc.ca
AN - 10805823
AU - Kerr, C. R.
AU - Gent, M.
AU - Roberts, R. S.
AU - Yusuf, S.
AU - Gillis, A. M.
AU - Sami, M. H.
AU - Talajic, M.
AU - Tang, A. S.
AU - Klein, G. J.
AU - Lau, C.
AU - Newman, D. M.
DA - May 11
DO - 10.1056/nejm200005113421902
DP - NLM
ET - 2001/02/07
IS - 19
KW - Aged
Atrial Fibrillation/epidemiology/etiology
Bradycardia/*therapy
Cardiac Pacing, Artificial/adverse effects/*methods
Female
Heart Block/therapy
Humans
Male
Risk
Stroke/epidemiology/prevention & control
LA - eng
N1 - Connolly, S J
Kerr, C R
Gent, M
Roberts, R S
Yusuf, S
Gillis, A M
Sami, M H
Talajic, M
Tang, A S
Klein, G J
Lau, C
Newman, D M
Clinical Trial
Journal Article
Multicenter Study
United States
N Engl J Med. 2000 May 11;342(19):1385-91. doi: 10.1056/NEJM200005113421902.
PY - 2000
SN - 0028-4793 (Print)
0028-4793
SP - 1385-91
ST - Effects of physiologic pacing versus ventricular pacing on the risk of stroke
and death due to cardiovascular causes. Canadian Trial of Physiologic Pacing
Investigators
T2 - N Engl J Med
TI - Effects of physiologic pacing versus ventricular pacing on the risk of stroke
and death due to cardiovascular causes. Canadian Trial of Physiologic Pacing
Investigators
VL - 342
ID - 2622
ER -
TY - JOUR
AB - Stroke, or cerebrovascular accident (CVA), is a medical emergency that may
lead to permanent neurological damage, complications, and death. The rapid loss of
brain function due to disruption of the blood supply to the brain is caused by
blockage (thrombosis, arterial embolism) or hemorrhage. The incidence of CVA during
anesthesia for noncardiac nonvascular surgery is as high as 1% depending on risk
factors. Comprehensive preoperative assessment and good perioperative management
may prevent a CVA. However, should an ischemic event occur, appropriate and rapid
management is necessary to minimize the deleterious effects caused to the patient.
This case report describes a patient who had an ischemic CVA while under general
anesthesia for dental alveolar surgery and discusses the anesthesia management.
AD - Assistant Professor, Department of Dental Anesthesiology, University of
Pittsburgh School of Dental Medicine, Pittsburgh, Pennsylvania.
AN - 24932981
AU - Cooke, M.
AU - Cuddy, M. A.
AU - Farr, B.
AU - Moore, P. A.
C2 - PMC4068093
DA - Summer
DO - 10.2344/0003-3006-61.2.73
DP - NLM
ET - 2014/06/17
IS - 2
J2 - Anesthesia progress
KW - Adult
Alveoloplasty/methods
*Anesthesia, Dental
*Anesthesia, General
Arrhythmia, Sinus/etiology
Bradycardia/etiology
Brain Ischemia/etiology
Carotid Stenosis/*complications
Electroencephalography/methods
Female
Humans
Hypotension/etiology
*Intraoperative Complications
Intubation, Intratracheal/methods
*Oral Surgical Procedures
Stroke/*etiology
Tomography, X-Ray Computed/methods
Tooth Extraction/methods
Ventricular Premature Complexes/etiology
Cerebrovascular event
Complication
Dentistry.
General anesthesia
LA - eng
N1 - Cooke, Mathew
Cuddy, Michael A
Farr, Brad
Moore, Paul A
Case Reports
Journal Article
Anesth Prog. 2014 Summer;61(2):73-7. doi: 10.2344/0003-3006-61.2.73.
PY - 2014
SN - 0003-3006 (Print)
0003-3006
SP - 73-7
ST - Cerebrovascular accident under anesthesia during dental surgery
T2 - Anesth Prog
TI - Cerebrovascular accident under anesthesia during dental surgery
VL - 61
ID - 2611
ER -
TY - JOUR
AB - BACKGROUND: The AFFIRM Study showed that treatment of patients with atrial
fibrillation and a high risk for stroke or death with a rhythm-control strategy
offered no survival advantage over a rate-control strategy in an intention-to-treat
analysis. This article reports an "on-treatment" analysis of the relationship of
survival to cardiac rhythm and treatment as they changed over time. METHODS AND
RESULTS: Modeling techniques were used to determine the relationships among
survival, baseline clinical variables, and time-dependent variables. The following
baseline variables were significantly associated with an increased risk of death:
increasing age, coronary artery disease, congestive heart failure, diabetes, stroke
or transient ischemic attack, smoking, left ventricular dysfunction, and mitral
regurgitation. Among the time-dependent variables, the presence of sinus rhythm
(SR) was associated with a lower risk of death, as was warfarin use. Antiarrhythmic
drugs (AADs) were associated with increased mortality only after adjustment for the
presence of SR. Consistent with the original intention-to-treat analysis, AADs were
no longer associated with mortality when SR was removed from the model.
CONCLUSIONS: Warfarin use improves survival. SR is either an important determinant
of survival or a marker for other factors associated with survival that were not
recorded, determined, or included in the survival model. Currently available AADs
are not associated with improved survival, which suggests that any beneficial
antiarrhythmic effects of AADs are offset by their adverse effects. If an effective
method for maintaining SR with fewer adverse effects were available, it might be
beneficial.
AD - Axio Research Corporation, Seattle, Wash, USA.
AN - 15007003
AU - Corley, S. D.
AU - Epstein, A. E.
AU - DiMarco, J. P.
AU - Domanski, M. J.
AU - Geller, N.
AU - Greene, H. L.
AU - Josephson, R. A.
AU - Kellen, J. C.
AU - Klein, R. C.
AU - Krahn, A. D.
AU - Mickel, M.
AU - Nelson, J. D.
AU - Rosenberg, Y.
AU - Schron, E.
AU - Shemanski, L.
AU - Waldo, A. L.
AU - Wyse, D. G.
DA - Mar 30
DO - 10.1161/01.Cir.0000121736.16643.11
DP - NLM
ET - 2004/03/10
IS - 12
J2 - Circulation
Amiodarone/therapeutic use
Anti-Arrhythmia Agents/adverse effects/therapeutic use
Atrial Fibrillation/complications/drug therapy/mortality/physiopathology/*therapy
Calcium Channel Blockers/therapeutic use
Combined Modality Therapy
Comorbidity
Digoxin/therapeutic use
Follow-Up Studies
Heart Rate
Humans
Models, Cardiovascular
Myocardial Contraction
Phenethylamines/therapeutic use
Risk
Sulfonamides/therapeutic use
Survival Analysis
Treatment Failure
Treatment Outcome
LA - eng
N1 - 1524-4539
Corley, Scott D
Epstein, Andrew E
DiMarco, John P
Domanski, Michael J
Geller, Nancy
Greene, H Leon
Josephson, Richard A
Kellen, Joyce C
Klein, Richard C
Krahn, Andrew D
Mickel, Mary
Mitchell, L Brent
Nelson, Joy Dalquist
Rosenberg, Yves
Schron, Eleanor
Shemanski, Lynn
Waldo, Albert L
Wyse, D George
AFFIRM Investigators
Clinical Trial
Comparative Study
Journal Article
Multicenter Study
United States
Circulation. 2004 Mar 30;109(12):1509-13. doi: 10.1161/01.CIR.0000121736.16643.11.
Epub 2004 Mar 8.
PY - 2004
SN - 0009-7322
SP - 1509-13
ST - Relationships between sinus rhythm, treatment, and survival in the Atrial
Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) Study
T2 - Circulation
TI - Relationships between sinus rhythm, treatment, and survival in the Atrial
Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) Study
VL - 109
ID - 2558
ER -
TY - JOUR
AB - PURPOSE: To investigate the pathologic substrates of sudden death in young
competitive athletes. PATIENTS AND METHODS: Twenty-two cases of sudden death in
young competitive athletes occurring in the Veneto region (northern Italy) in the
period January 1979 to December 1989 were studied by postmortem examination. The
athletes included 19 males and three females, ranging in age from 11 to 35 years
(mean, 23 years). RESULTS: In 18 cases, sudden death occurred during (16 cases) or
immediately after (two cases) a competitive sport activity. In 10 subjects, sudden
death was apparently the first sign of disease. Postmortem examination disclosed
that this fatality was due to arrhythmic cardiac arrest in 17 cases; among these,
right ventricular cardiomyopathy, also known as "right ventricular dysplasia," was
the most frequently encountered cardiovascular disease (six cases), followed by
atherosclerotic coronary artery disease (four cases), conduction system pathology
(three cases), anomalous origin of right coronary artery from the wrong aortic
sinus (two cases), and mitral valve prolapse (two cases). In two athletes, the
abrupt lethal complication was "mechanical" and consisted of pulmonary embolism and
rupture of the aorta; in three athletes, death was due to a cerebral cause. All
athletes with right ventricular cardiomyopathy died during effort, and most had a
history of palpitations and/or syncope. Whenever available, electrocardiographic
(ECG) tracings showed inverted T waves in precordial leads and/or left bundle
branch block ventricular arrhythmias. CONCLUSIONS: Clinicopathologic correlations
indicate that in the Veneto region of Italy, right ventricular cardiomyopathy is
not so rare among the cardiovascular diseases associated with the risk of
arrhythmic cardiac arrest, and seems to account for the majority of cases of sudden
death in young athletes; this disorder can be suspected during life on the basis of
prodromal symptoms and ECG signs.
AD - Department of Pathology, University of Padua Medical School, Italy.
AN - 2239978
AU - Corrado, D.
AU - Thiene, G.
AU - Nava, A.
AU - Rossi, L.
AU - Pennelli, N.
DA - Nov
DO - 10.1016/0002-9343(90)90176-e
DP - NLM
ET - 1990/11/01
IS - 5
J2 - The American journal of medicine
KW - Adolescent
Adult
Arrhythmias, Cardiac/complications/pathology
Cardiomyopathies/complications/pathology
Child
Coronary Artery Disease/complications/pathology
Coronary Vessel Anomalies/complications/pathology
Death, Sudden/*etiology/pathology
Female
Heart Diseases/*complications/pathology
Humans
Italy
Male
Mitral Valve Prolapse/complications/pathology
Myocardium/pathology
*Sports
LA - eng
N1 - Corrado, D
Thiene, G
Nava, A
Rossi, L
Pennelli, N
Journal Article
United States
Am J Med. 1990 Nov;89(5):588-96. doi: 10.1016/0002-9343(90)90176-e.
PY - 1990
SN - 0002-9343 (Print)
0002-9343
SP - 588-96
ST - Sudden death in young competitive athletes: clinicopathologic correlations in
22 cases
T2 - Am J Med
TI - Sudden death in young competitive athletes: clinicopathologic correlations in
22 cases
VL - 89
ID - 2876
ER -
TY - JOUR
AB - BACKGROUND: Atrial fibrillation (AF) is a known risk factor for ischemic
stroke. Electrocardiographic predictors of AF in population studies such as the
Framingham Heart Study, as well as in hypertensive patients have demonstrated a
predictive value of the P-wave duration for development of AF. QRS vector magnitude
has had a predictive value in ventricular arrhythmia development. We aimed to
assess the value of the three-dimensional P-wave vector magnitude and its
relationship to P-wave duration for prediction of new-onset AF after ischemic
stroke. METHODS: First-ever ischemic stroke patients without AF at inclusion in the
Lund Stroke Register were included. Measurements of P wave duration (Pd), QRS
duration, corrected QT interval, and PQ interval were performed automatically using
the University of Glasgow 12-lead ECG analysis algorithm. The P-wave vector
magnitude (Pvm) was calculated automatically as the square root of the sum of the
squared P-wave magnitudes in leads V6, II and one half of the P-wave amplitude in
V2 ([Formula: see text]), based on the P-wave magnitude (Pvm) as defined by the
visually transformed Kors' Quasi-orthogonal method. RESULTS: The median age was 73
(IQR 63-80) years at stroke onset (135 males, 92 females). Multivariate predictors
of new-onset atrial fibrillation included age > 65 years, hypertension, and Pd/Pvm.
A cut-off value of 870 ms/mV gave sensitivity, specificity, positive and negative
predictive values of 51, 79, 30 and 87%, respectively. The Pd/Pvm was the only ECG
predictor of AF with a significant multivariate hazard ratio of 2.02 (95% CI 1.18
to 3.46, p = 0.010). CONCLUSION: P-wave dispersion as measured by the Pd/Pvm was
the only ECG parameter measured which independently predicted subsequent AF
identification in a cohort of stroke patients. Further prospective studies in
larger cohorts are needed to validate its clinical usefulness.
AD - Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden.
dr.danielcortez@gmail.com.
Electrophysiology Department, Penn State Milton S. Hershey Medical Center, Hershey,
USA. dr.danielcortez@gmail.com.
Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden.
St. Petersburg University Clinic, St. Petersburg, Russia.
Cardiology Research, Clinical and Educational Center, St. Petersburg State
University, St. Petersburg, Russia.
Department of Neurology and Rehabilitation Medicine, Skane University Hospital,
Lund, Sweden.
Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden.
Arrhythmia Clinic, Skåne University Hospital, Lund, Sweden.
AN - 28738786
AU - Cortez, D.
AU - Baturova, M.
AU - Lindgren, A.
AU - Carlson, J.
AU - Shubik, Y. V.
AU - Olsson, B.
AU - Platonov, P. G.
C2 - PMC5525302
DA - Jul 24
DO - 10.1186/s12872-017-0631-1
DP - NLM
ET - 2017/07/26
IS - 1
Aged
Aged, 80 and over
Algorithms
Atrial Fibrillation/diagnosis/*etiology/physiopathology
Brain Ischemia/complications/*diagnosis/physiopathology
Female
Heart Rate
Humans
Male
Middle Aged
Patient Admission
Prognosis
Registries
Risk Factors
Signal Processing, Computer-Assisted
Stroke/complications/*diagnosis/physiopathology
Sweden
Time Factors
*Ischemic stroke
*P-wave duration
*P-wave vector magnitude
Register and thus all patients were consented and the study was approved by the
Internal Review Board of Lund University and Skane Hospital and conformed to the
Declaration of Helsinki and which included analysis of ECG variables. CONSENT FOR
PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they
have
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LA - eng
N1 - 1471-2261
Cortez, Daniel
Orcid: 0000-0001-9874-0733
Baturova, Maria
Lindgren, Arne
Carlson, Jonas
Shubik, Yuri V
Olsson, Bertil
Platonov, Pyotr G
Journal Article
BMC Cardiovasc Disord. 2017 Jul 24;17(1):200. doi: 10.1186/s12872-017-0631-1.
PY - 2017
SN - 1471-2261
SP - 200
ST - Atrial time and voltage dispersion are both needed to predict new-onset
atrial fibrillation in ischemic stroke patients
TI - Atrial time and voltage dispersion are both needed to predict new-onset
atrial fibrillation in ischemic stroke patients
VL - 17
ID - 2341
ER -
TY - JOUR
AB - OBJECTIVE: To evaluate the dimensions of atrial septal aneurysm (ASA), the
presence and characteristics of interatrial shunt, the movement of the wall of the
aneurysm, and correlation between these findings and sign and/or symptoms
suggesting embolism in Manisa, a district of a western Anatolian city of Turkey.
METHODS: Two thousand five hundred cases were examined by routine transthoracic
echocardiography (TTE) in both pediatric and adult cardiology outpatient clinics.
ASA was detected in 20 cases and evaluated by two-dimensional color Doppler
echocardiography (CDE). The length of the base, the maximum radius and the maximum
displacement of ASA were measured. The shunt between the atria was examined by CDE.
In cases where a shunt could not be found, galactose and palmitic acid was
injected. Standard 12-lead electrocardiogram (ECG) and exercise stress test were
also performed. RESULTS: No clinical signs or symptoms were found, suggesting a
systemic or cerebral embolism. The maximum displacement of ASA was between 2 and 5
mm. All of the aneurysms were localized in the right atrium, and the walls of the
aneurysm did not move beyond the base of the left atrium during the maximum
displacement. Interatrial shunt was detected in 14 of 20 patients (70%) by CDE and
in the remaining six cases by contrast TTE. Frequent ventricular ectopic beats were
observed in one patient. CONCLUSIONS: During routine TTE we observed 0.8%
asymptomatic ASA in our population. The use of a contrast agent was found to be a
valuable additional method in patients with ASA when the shunt could not be
detected by CDE. The risk for embolism is not high when the maximum displacement of
the wall of ASA was 5 mm or less and no bulge into the left atrium was observed.
Based on our experience with this method, TTE is easy to perform, well-tolerated
and acceptable.
AD - Department of Pediatric Cardiology, Faculty of Medicine, Celal Bayer
University, Manisa, Turkey. coskunsenol@Hotmail.com
AN - 12875684
AU - Coskun, S.
AU - Sekuri, C.
AU - Bayturan, O.
AU - Yüksel, H.
AU - Saribülbül, O.
AU - Bilge, A.
DA - May
DP - NLM
ET - 2003/07/24
IS - 5
J2 - Chinese medical journal
KW - Adolescent
Adult
Child
Child, Preschool
*Echocardiography, Doppler, Color
Female
Heart Aneurysm/*diagnostic imaging
Heart Atria
Humans
Infant
Male
Middle Aged
LA - eng
N1 - Coskun, Senol
Sekuri, Cevad
Bayturan, Ozgür
Yüksel, Hasan
Saribülbül, Osman
Bilge, Ali
Journal Article
China
Chin Med J (Engl). 2003 May;116(5):699-702.
PY - 2003
SN - 0366-6999 (Print)
0366-6999
SP - 699-702
ST - Diagnosis of asymptomatic atrial septal aneurysms using two-dimensional color
Doppler and contrast transthoracic echocardiography
T2 - Chin Med J (Engl)
TI - Diagnosis of asymptomatic atrial septal aneurysms using two-dimensional color
Doppler and contrast transthoracic echocardiography
VL - 116
ID - 3145
ER -
TY - JOUR
AB - OBJECTIVE: We sought to assess short- and long-term prognosis of syncope and
associated risk factors. BACKGROUND: Syncope is a common clinical event, but our
knowledge of its short-term outcome is largely incomplete. Further, it is unknown
whether hospital admission might positively affect a patient's syncope prognosis.
METHODS: We screened 2,775 consecutive subjects who presented for syncope at 4
emergency departments between January and July 2004. Short- and long-term severe
outcomes (i.e., death and major therapeutic procedures) and related risk factors
were compared in all enrolled patients arrayed according to hospital admission or
discharge. RESULTS: A total of 676 subjects were included in the study. Forty-one
subjects (6.1%) experienced severe outcomes (5 deaths, 0.7%; 36 major therapeutic
procedures, 5.4%) in the 10 days after presentation. An abnormal electrocardiogram,
concomitant trauma, absence of symptoms of impending syncope, and male gender were
associated with short-term unfavorable outcomes. Long-term severe outcomes were
9.3% (40 deaths, 6.0%; 22 major therapeutic procedures, 3.3%), and their occurrence
was correlated with an age >65 years, history of neoplasms, cerebrovascular
diseases, structural heart diseases, and ventricular arrhythmias. Short-term major
therapeutic procedures were more common (p < 0.05) in subjects who had been
admitted to hospital (13.3%) than in discharged (1.6%), whereas mortality was
similar. One-year mortality was greater (p < 0.05) in admitted (14.7%) than in
discharged (1.8%) patients. CONCLUSIONS: Risk factors for short- and long-term
adverse outcomes after syncope differed. Hospital admission favorably influenced
syncope short term prognosis. Instead, 1-year mortality was unaffected by hospital
admission and related to comorbidity.
AD - Syncope Unit, Internal Medicine II, L. Sacco Hospital, University of Milan,
Milan, Italy.
AN - 18206736
AU - Costantino, G.
AU - Perego, F.
AU - Dipaola, F.
AU - Borella, M.
AU - Galli, A.
AU - Cantoni, G.
AU - Dell'Orto, S.
AU - Dassi, S.
AU - Filardo, N.
AU - Duca, P. G.
AU - Montano, N.
AU - Furlan, R.
DA - Jan 22
DO - 10.1016/j.jacc.2007.08.059
DP - NLM
ET - 2008/01/22
IS - 3
KW - Adult
Age Factors
Aged
Analysis of Variance
Arrhythmias, Cardiac/*complications
Cause of Death
Comorbidity
Female
*Hospitalization
Humans
Male
Middle Aged
Prognosis
Prospective Studies
Risk Factors
Syncope/*complications/*mortality
LA - eng
N1 - 1558-3597
Costantino, Giorgio
Perego, Francesca
Dipaola, Franca
Borella, Marta
Galli, Andrea
Cantoni, Giulia
Dell'Orto, Simonetta
Dassi, Simonetta
Filardo, Nicola
Duca, Pier Giorgio
Montano, Nicola
Furlan, Raffaello
STePS Investigators
Journal Article
Multicenter Study
United States
J Am Coll Cardiol. 2008 Jan 22;51(3):276-83. doi: 10.1016/j.jacc.2007.08.059.
PY - 2008
SN - 0735-1097
SP - 276-83
ST - Short- and long-term prognosis of syncope, risk factors, and role of hospital
admission: results from the STePS (Short-Term Prognosis of Syncope) study
TI - Short- and long-term prognosis of syncope, risk factors, and role of hospital
admission: results from the STePS (Short-Term Prognosis of Syncope) study
VL - 51
ID - 2993
ER -
TY - JOUR
AB - Primary vascular prevention: the prevalence of cardiogenic stroke will
increase in the future. All patients with atrial fibrillation but without any
ischemic stroke, must undergo a rigorous risk evaluation, which is crucial for
pharmacotherapy. Atrial fibrillation is an important risk factor for stroke,
therefore patients with atrial fibrillation should be anticoagulated (except those
without other risk factors). Even patients over 75 years with atrial fibrillation
could be anticoagulated if the INR is properly controlled. The authors review also
the role of anticoagulation in patients suffering from myocardial infarction or
valve diseases. Acute stroke: The new European stroke guideline does not recommend
the use of conventional or fractionated heparin in the first three days of acute
stroke, but aspirin therapy is recommended. Long-term anticoagulation is needed
only if cardiac source of emboli can be verified, the patient has good compliance,
and the risk of hemorrhagic complication is low (INR: 2-3). Otherwise, antiplatelet
therapy is recommended. Some authors recommend early anticoagulation in special
cases (high risk of embolisation, left atrial/ventricular thrombus, arterial
dissection or surgical intervention for a severe arterial stenosis). Caution is
needed in patients with large infarct, uncontrolled hypertension and microbleeds on
MRI. Secondary prevention: Antiplatelet therapy is recommended for every post-
stroke patient, but for those with cardiac source of emboli anticoagulation is
recommended.
AD - Debreceni Egyetem, Altalános Orvostudományi Kar, Orvos- és Egészségtudományi
Centrum Neurológiai Klinika Debrecen Móricz Zsigmond krt. 22. 4032. csiba@dote.hu
AN - 19158017
AU - Csiba, L.
AU - Kovács, K. R.
DA - Feb 1
DO - 10.1556/oh.2009.28414
DP - NLM
ET - 2009/01/23
IS - 5
J2 - Orvosi hetilap
KW - Acute Disease
Anticoagulants/administration & dosage
Aspirin/administration & dosage
Heart Diseases/*complications/*drug therapy
Heart Valve Diseases/complications/drug therapy
Heparin/administration & dosage
Humans
Myocardial Infarction/complications/drug therapy
Primary Prevention/*methods
LA - hun
N1 - Csiba, László
Kovács, Katalin Réka
English Abstract
Journal Article
Review
Hungary
Orv Hetil. 2009 Feb 1;150(5):195-202. doi: 10.1556/OH.2009.28414.
OP - Antithromboticus kezelés szívbetegek elsodleges és másodlagos stroke-
prevenciójában és akut stroke-ban.
PY - 2009
SN - 0030-6002 (Print)
0030-6002
SP - 195-202
ST - [Antithrombotic therapy in primary and secondary stroke prevention of cardiac
patients and in acute stroke]
T2 - Orv Hetil
TI - [Antithrombotic therapy in primary and secondary stroke prevention of cardiac
patients and in acute stroke]
VL - 150
ID - 2385
ER -
TY - JOUR
AB - BACKGROUND: Recent advances have enabled noninvasive mapping of cardiac
arrhythmias with electrocardiographic imaging and noninvasive delivery of precise
ablative radiation with stereotactic body radiation therapy (SBRT). We combined
these techniques to perform catheter-free, electrophysiology-guided, noninvasive
cardiac radioablation for ventricular tachycardia. METHODS: We targeted
arrhythmogenic scar regions by combining anatomical imaging with noninvasive
electrocardiographic imaging during ventricular tachycardia that was induced by
means of an implantable cardioverter-defibrillator (ICD). SBRT simulation,
planning, and treatments were performed with the use of standard techniques.
Patients were treated with a single fraction of 25 Gy while awake. Efficacy was
assessed by counting episodes of ventricular tachycardia, as recorded by ICDs.
Safety was assessed by means of serial cardiac and thoracic imaging. RESULTS: From
April through November 2015, five patients with high-risk, refractory ventricular
tachycardia underwent treatment. The mean noninvasive ablation time was 14 minutes
(range, 11 to 18). During the 3 months before treatment, the patients had a
combined history of 6577 episodes of ventricular tachycardia. During a 6-week
postablation "blanking period" (when arrhythmias may occur owing to postablation
inflammation), there were 680 episodes of ventricular tachycardia. After the 6-week
blanking period, there were 4 episodes of ventricular tachycardia over the next 46
patient-months, for a reduction from baseline of 99.9%. A reduction in episodes of
ventricular tachycardia occurred in all five patients. The mean left ventricular
ejection fraction did not decrease with treatment. At 3 months, adjacent lung
showed opacities consistent with mild inflammatory changes, which had resolved by 1
year. CONCLUSIONS: In five patients with refractory ventricular tachycardia,
noninvasive treatment with electrophysiology-guided cardiac radioablation markedly
reduced the burden of ventricular tachycardia. (Funded by Barnes-Jewish Hospital
Foundation and others.).
AD - From the Department of Internal Medicine, Cardiovascular Division (P.S.C.,
D.C., M.F., M.G., A.N., T.W.S.), and the Departments of Surgery (M.R.S.), Radiation
Oncology (R.K., S.M., D.H., C.G.R.), Pathology (A.L.), and Cell Biology and
Physiology, Medicine, Radiology, and Pediatrics (Y.R.), School of Medicine, and the
Department of Biomedical Engineering, School of Engineering and Applied Science
(Y.R.), Washington University in St. Louis, St. Louis.
AN - 29236642
AU - Cuculich, P. S.
AU - Schill, M. R.
AU - Kashani, R.
AU - Mutic, S.
AU - Lang, A.
AU - Cooper, D.
AU - Faddis, M.
AU - Gleva, M.
AU - Noheria, A.
AU - Smith, T. W.
AU - Hallahan, D.
AU - Rudy, Y.
AU - Robinson, C. G.
C2 - PMC5764179
C6 - NIHMS931621
DA - Dec 14
DO - 10.1056/NEJMoa1613773
DP - NLM
ET - 2017/12/14
IS - 24
KW - Aged
Aged, 80 and over
Catheter Ablation/*methods
Cicatrix/complications/pathology
Electrocardiography
Electrophysiologic Techniques, Cardiac
Fatal Outcome
Female
Heart Ventricles/diagnostic imaging/pathology/physiopathology
Humans
Male
Middle Aged
*Radiosurgery/adverse effects/methods
Stroke/etiology
Stroke Volume
Tachycardia, Ventricular/etiology/physiopathology/*radiotherapy
LA - eng
N1 - 1533-4406
Cuculich, Phillip S
Schill, Matthew R
Kashani, Rojano
Mutic, Sasa
Lang, Adam
Cooper, Daniel
Faddis, Mitchell
Gleva, Marye
Noheria, Amit
Smith, Timothy W
Hallahan, Dennis
Rudy, Yoram
Robinson, Clifford G
Case Reports
Journal Article
N Engl J Med. 2017 Dec 14;377(24):2325-2336. doi: 10.1056/NEJMoa1613773.
PY - 2017
SN - 0028-4793 (Print)
0028-4793
SP - 2325-2336
ST - Noninvasive Cardiac Radiation for Ablation of Ventricular Tachycardia
T2 - N Engl J Med
TI - Noninvasive Cardiac Radiation for Ablation of Ventricular Tachycardia
VL - 377
ID - 2280
ER -
TY - JOUR
AB - BACKGROUND AND PURPOSE: Embolism is believed to be the major cause of stroke
in patients with nonvalvular atrial fibrillation (NVAF). The detection of
asymptomatic embolic signals (ES) in individuals with NVAF might allow
identification of patients at high risk of stroke and monitoring of therapy in
individual subjects. We determined the frequency of asymptomatic ES in patients
with NVAF who were not taking warfarin. METHODS: Bilateral transcranial Doppler
recordings were made for 1 hour from the middle cerebral arteries of 111 successive
patients with NVAF taking aspirin alone or no antithrombotic or anticoagulant
therapy. Adequate recordings could be made in 86 patients. In 79 subjects,
recordings were performed on a second occasion to study temporal variability.
Recordings for a single hour were also made in 30 age-matched control subjects.
RESULTS: ES were detected in 13 (15.1%) of NVAF subjects but in no control subjects
(P=0.02). ES were detected both in subjects with symptomatic NVAF (4 of 30 [13.1%],
P=0.04 versus controls) and asymptomatic NVAF (9 of 56 [16.1%], P=0.02 versus
controls). There was no correlation between the presence of ES and smoking status,
diabetes, hypertension, aspirin use, aspirin dose, symptomatic status, left atrial
size, left ventricular function, or the presence of left atrial thrombus detected
on transthoracic echocardiography. Repeating the recording increased the number of
patients with ES to 21 (26.6%). On considering the results of both recordings,
again there was no association for either recording between the presence of ES and
smoking status, diabetes, hypertension, aspirin use, aspirin dose, age, symptomatic
status, left atrial size, or left ventricular function. On repeating the recording,
in the symptomatic group only 2 patients (8%) changed status, in contrast to 15
(29%) in the asymptomatic group. CONCLUSIONS: ES can be detected in patients with
NVAF at a low frequency. Particularly in asymptomatic patients, ES show marked
temporal variability. We found no correlation between the presence of previously
reported clinical and echocardiographic markers of increased stroke risk and the
presence of ES. This association requires further investigation before the clinical
utility of this technique in patients with NVAF is decided.
AD - Department of Clinical Neurosciences, King's College School of Medicine and
Institute of Psychiatry, King's College Hospital, London, UK.
AN - 9731600
AU - Cullinane, M.
AU - Wainwright, R.
AU - Brown, A.
AU - Monaghan, M.
AU - Markus, H. S.
DA - Sep
DO - 10.1161/01.str.29.9.1810
DP - NLM
ET - 1998/09/10
IS - 9
J2 - Stroke
KW - Aged
Aged, 80 and over
Atrial Fibrillation/*complications/*drug therapy
Echocardiography
Female
Humans
Intracranial Embolism and Thrombosis/diagnostic imaging/epidemiology/*etiology
Male
Middle Aged
Prospective Studies
Risk Factors
Time Factors
LA - eng
N1 - Cullinane, M
Wainwright, R
Brown, A
Monaghan, M
Markus, H S
Journal Article
United States
Stroke. 1998 Sep;29(9):1810-5. doi: 10.1161/01.str.29.9.1810.
PY - 1998
SN - 0039-2499 (Print)
0039-2499
SP - 1810-5
ST - Asymptomatic embolization in subjects with atrial fibrillation not taking
anticoagulants: a prospective study
T2 - Stroke
TI - Asymptomatic embolization in subjects with atrial fibrillation not taking
anticoagulants: a prospective study
VL - 29
ID - 2986
ER -
TY - JOUR
AB - BACKGROUND: Studies have shown that patients with schizophrenia have higher
rates of cardiovascular disease and mortality compared with the general population.
However, population-based data on the prevalence, incidence, and mortality of
cardiovascular disease are needed. METHOD: In this retrospective cohort study, the
Saskatchewan Health databases were searched for all patients diagnosed with
schizophrenia (ICD-9 code 295) in 1994 or 1995. 3022 subjects were identified. For
each subject, 4 age- and sex-matched comparison individuals were selected randomly
among residents of the province who had no diagnosis of schizophrenia or any other
mental disorders and who received no prescriptions for antipsychotic medications.
Prevalence of cardiovascular morbidity during 1994 and 1995 and incidence of
cardiovascular morbidity and mortality during the follow-up period of January 1996
through March 1999 were analyzed. RESULTS: Concerning prevalence of morbidity in
schizophrenia patients, significantly increased risk-adjusted odds ratios were as
follows: arrhythmia, 1.5 (95% CI = 1.2 to 1.8); syncope, 4.0 (95% CI = 2.0 to 7.9);
heart failure, 1.7 (95% CI = 1.4 to 2.2); stroke, 2.1 (95% CI = 1.6 to 2.7);
transient cerebral ischemia, 2.6 (95% CI = 1.7 to 3.7); and diabetes, 2.1 (95% CI =
1.8 to 2.4). Odds of acute myocardial infarction, ischemic heart disease, and
ventricular arrhythmias were not significantly different from those for the
comparison group. Concerning incidence of morbidity and mortality in the patients,
adjusted relative risk was significantly increased for ventricular arrhythmia, 2.3
(95% CI = 1.2 to 4.3); heart failure, 1.6 (95% CI = 1.2 to 2.0); stroke, 1.5 (95%
CI = 1.2 to 2.0); diabetes, 1.8 (95% CI = 1.2 to 2.6); all-cause mortality, 2.8
(95% CI = 2.3 to 3.4); and cardiovascular mortality, 2.2 (95% CI = 1.7 to 2.8).
CONCLUSIONS: Persons with schizophrenia appear to be at greater risk for
cardiovascular morbidity and mortality than those in the general population.
AD - Healthcare Data Analysis, Vienna, VA 22180, USA. Suellen.Curkendall@cox.net
AN - 15163261
AU - Curkendall, S. M.
AU - Mo, J.
AU - Glasser, D. B.
AU - Rose Stang, M.
AU - Jones, J. K.
DA - May
DO - 10.4088/jcp.v65n0519
DP - NLM
ET - 2004/05/28
IS - 5
J2 - The Journal of clinical psychiatry
KW - Adult
Antipsychotic Agents/therapeutic use
Cardiovascular Diseases/*epidemiology/mortality
Cause of Death/trends
Cohort Studies
Comorbidity
Female
Humans
Incidence
Insurance Claim Reporting/statistics & numerical data
Male
Middle Aged
Odds Ratio
Prevalence
Risk
Saskatchewan/epidemiology
Schizophrenia/drug therapy/*epidemiology/mortality
LA - eng
N1 - Curkendall, Suellen M
Mo, Jingping
Glasser, Dale B
Rose Stang, Mary
Jones, Judith K
Comparative Study
Journal Article
United States
J Clin Psychiatry. 2004 May;65(5):715-20. doi: 10.4088/jcp.v65n0519.
PY - 2004
SN - 0160-6689 (Print)
0160-6689
SP - 715-20
ST - Cardiovascular disease in patients with schizophrenia in Saskatchewan, Canada
T2 - J Clin Psychiatry
TI - Cardiovascular disease in patients with schizophrenia in Saskatchewan, Canada
VL - 65
ID - 3076
ER -
TY - JOUR
AB - Treatment strategies in patients with atrial fibrillation typically involve
pharmacologic or interventional invasive therapies to suppress the rhythm, control
ventricular contraction rates, or prevent thromboembolic complications. Current
therapies used for rhythm conversion in atrial fibrillation may have undesirable
risks or side effects that limit this approach. Lifelong anticoagulation may be
necessary to prevent the formation of thrombus in the left atrial chamber that can
travel into the cerebral circulation to cause a stroke. Currently, warfarin is the
most commonly prescribed anticoagulant for this purpose. Unfortunately, many
patients with atrial fibrillation may not receive warfarin because of the
difficulties in dosing and maintaining desirable target goals. The oral direct
thrombin inhibitor ximelagatran has several pharmacologic properties that provide a
unique and potentially desirable treatment option. Clinical studies have
demonstrated that ximelagatran, administered in twice-daily doses of 36 mg, is non-
inferior to warfarin for thromboprophylaxis against stroke or systemic embolism in
atrial fibrillation. The pharmacology of ximelagatran and clinical trials with its
use in atrial fibrillation is reviewed.
AD - Department of Pharmaceutical Services, University of California, Davis
Medical Center and School of Medicine, CA 95817-2201, USA.
william.dager@ucdmc.ucdavis.edu
AN - 15378135
AU - Dager, W. E.
DA - Sep
DO - 10.1177/107424840400900302
DP - NLM
ET - 2004/09/21
IS - 3
J2 - Journal of cardiovascular pharmacology and therapeutics
KW - Animals
Atrial Fibrillation/*drug therapy/metabolism
Azetidines/pharmacokinetics/*therapeutic use
Benzylamines
Clinical Trials as Topic/statistics & numerical data
Fibrinolytic Agents/pharmacokinetics/*therapeutic use
Humans
LA - eng
N1 - Dager, William E
Journal Article
Review
United States
J Cardiovasc Pharmacol Ther. 2004 Sep;9(3):151-62. doi: 10.1177/107424840400900302.
PY - 2004
SN - 1074-2484 (Print)
1074-2484
SP - 151-62
ST - Ximelagatran: a new antithrombotic option in atrial fibrillation
T2 - J Cardiovasc Pharmacol Ther
TI - Ximelagatran: a new antithrombotic option in atrial fibrillation
VL - 9
ID - 2941
ER -
TY - JOUR
AB - OBJECTIVES: This study sought to investigate gender-related differences in
patients with atrial fibrillation (AF) in Europe. BACKGROUND: Gender-related
differences may play a significant role in AF. METHODS: We analyzed the data of
5,333 patients (42% female) enrolled in the Euro Heart Survey on Atrial
Fibrillation. RESULTS: Compared with men, the women were older, had a lower quality
of life (QoL), had more comorbidities, more often had heart failure (HF) with
preserved left ventricular systolic function (18% vs. 7%, p < 0.001), and less
often had HF with systolic dysfunction (17% vs. 26%, p < 0.001). Among patients
with typical AF symptoms (56% of women, 49% of men), there was no gender-related
difference in the choice of rate or rhythm control. Among patients with atypical or
no symptoms (44% of women, 51% of men), women less frequently underwent rhythm
control (39% vs. 51%, p < 0.001) than did men. Women underwent less electrical
cardioversion (22% vs. 28%, p < 0.001). Prescription of oral anticoagulants was
identical (65%) in both genders. One-year outcome was similar except that women had
a higher chance for stroke (odds ratio 1.83 in multivariable regression analysis, p
= 0.019). CONCLUSIONS: Women with AF had more comorbidities, more HF with preserved
systolic function, and a lower QoL than men. In the large group with atypical or no
symptoms, women were treated appropriately more conservatively with less rhythm
control than men. Women had a higher chance for stroke. Long-term QoL changes and
other morbidities and mortality were similar.
AD - University of Athens, Second Cardiology Department, Attikon University
Hospital, Athens, Greece. nikolaosdagres@yahoo.de
AN - 17276181
AU - Dagres, N.
AU - Nieuwlaat, R.
AU - Vardas, P. E.
AU - Andresen, D.
AU - Lévy, S.
AU - Cobbe, S.
AU - Kremastinos, D. T.
AU - Breithardt, G.
AU - Cokkinos, D. V.
AU - Crijns, H. J.
DA - Feb 6
DO - 10.1016/j.jacc.2006.10.047
DP - NLM
ET - 2007/02/06
IS - 5
KW - Aged
Aged, 80 and over
Atrial Fibrillation/*complications/diagnosis/*therapy
Europe
Female
Follow-Up Studies
Health Status
Health Surveys
Humans
Male
Middle Aged
Quality of Life
*Sex Factors
Stroke/etiology
Treatment Outcome
LA - eng
N1 - 1558-3597
Dagres, Nikolaos
Nieuwlaat, Robby
Vardas, Panos E
Andresen, Dietrich
Lévy, Samuel
Cobbe, Stuart
Kremastinos, Dimitrios Th
Breithardt, Günter
Cokkinos, Dennis V
Crijns, Harry J G M
Journal Article
Multicenter Study
United States
J Am Coll Cardiol. 2007 Feb 6;49(5):572-7. doi: 10.1016/j.jacc.2006.10.047. Epub
2007 Jan 22.
PY - 2007
SN - 0735-1097
SP - 572-7
ST - Gender-related differences in presentation, treatment, and outcome of
patients with atrial fibrillation in Europe: a report from the Euro Heart Survey on
Atrial Fibrillation
TI - Gender-related differences in presentation, treatment, and outcome of
patients with atrial fibrillation in Europe: a report from the Euro Heart Survey on
Atrial Fibrillation
VL - 49
ID - 2724
ER -
TY - JOUR
AB - Stroke remains one of the leading causes of death in the United States.
Current evidence identified electrocardiographic abnormalities and cardiac
arrhythmias in 50% of patients with an acute stroke. The purpose of this study was
to assess whether the presence of ventricular arrhythmia (VA) in adult patients
hospitalized in Florida with acute stroke increased the risk of in-hospital
mortality.Secondary data analysis of 215,150 patients with ischemic and hemorrhagic
stroke hospitalized in the state of Florida collected by the Florida Agency for
Healthcare Administration from 2008 to 2012. The main outcome for this study was
in-hospital mortality. The main exposure of this study was defined as the presence
of VA. VA included the ICD-9 CM codes: paroxysmal ventricular tachycardia (427.1),
ventricular fibrillation (427.41), ventricular flutter (427.42), ventricular
fibrillation and flutter (427.4), and other - includes premature ventricular beats,
contractions, or systoles (427.69). Differences in demographic and clinical
characteristics and hospital outcomes were assessed between patients who developed
versus did not develop VA during hospitalization (χ and t tests). Binary logistic
regression was used to estimate unadjusted and adjusted odds ratios and 95%
confidence intervals (CIs) between VA and in-hospital mortality.VA was associated
with an increased risk of in-hospital mortality after adjusting for all covariates
(odds ratio [OR]: 1.75; 95% CI: 1.6-1.2). There was an increased in-hospital
mortality in women compared to men (OR: 1.1; 95% CI: 1.1-1.14), age greater than 85
years (OR: 3.9, 95% CI: 3.5-4.3), African Americans compared to Whites (OR: 1.1;
95% CI: 1.04-1.2), diagnosis of congestive heart failure (OR: 2.1; 95% CI: 2.0-
2.3), and atrial arrhythmias (OR: 2.1, 95% CI: 2.0-2.2). Patients with hemorrhagic
stroke had increased odds of in-hospital mortality (OR: 9.0; 95% CI: 8.6-9.4)
compared to ischemic stroke.Identifying VAs in stroke patients may help in better
target at risk populations for closer cardiac monitoring during hospitalization.
The impact of implementing methods of quick assessment could potentially reduce VA
associated sudden cardiac death.
AD - aAmerican University of Antigua, College of Medicine, St. John's, Antigua
bDepartment of Medical and Population Health Sciences Research, Herbert Wertheim
College of Medicine, Florida International University, Miami, FL, USA.
AN - 28700475
AU - Dahlin, A. A.
AU - Parsons, C. C.
AU - Barengo, N. C.
AU - Ruiz, J. G.
AU - Ward-Peterson, M.
AU - Zevallos, J. C.
C2 - PMC5515747
DA - Jul
DO - 10.1097/md.0000000000007403
DP - NLM
ET - 2017/07/13
IS - 28
J2 - Medicine
KW - Age Factors
Aged
Aged, 80 and over
Arrhythmias, Cardiac/*complications/*mortality/therapy
Brain Ischemia/complications/mortality/therapy
Female
Florida
*Hospital Mortality
Humans
Intracranial Hemorrhages/complications/mortality/therapy
Male
Middle Aged
Prospective Studies
Risk Factors
Sex Factors
Stroke/*complications/*mortality/therapy
LA - eng
N1 - 1536-5964
Dahlin, Arielle A
Parsons, Chase C
Barengo, Noël C
Ruiz, Juan Gabriel
Ward-Peterson, Melissa
Zevallos, Juan Carlos
Journal Article
Medicine (Baltimore). 2017 Jul;96(28):e7403. doi: 10.1097/MD.0000000000007403.
PY - 2017
SN - 0025-7974 (Print)
0025-7974
SP - e7403
ST - Association of ventricular arrhythmia and in-hospital mortality in stroke
patients in Florida: A nonconcurrent prospective study
T2 - Medicine (Baltimore)
TI - Association of ventricular arrhythmia and in-hospital mortality in stroke
patients in Florida: A nonconcurrent prospective study
VL - 96
ID - 2339
ER -
TY - JOUR
AB - BACKGROUND: Dobutamine myocardial perfusion imaging is being used
increasingly for assessment of coronary artery disease. Heretofore, there have been
no large series documenting its tolerance and safety. The aims of this study were
to assess the tolerance, hemodynamic changes, and safety of dobutamine stress in
conjunction with myocardial perfusion imaging. METHODS AND RESULTS: The tolerance,
hemodynamic changes, and safety of dobutamine myocardial perfusion imaging were
investigated in a consecutive series of 1012 patients. Dobutamine was infused at
incremental doses of 10, 20, 30, and 40 micrograms/kg/min at 3-minute intervals.
Perfusion tomography was performed according to standard protocols with either
201Tl or 99mTc-labeled sestamibi. Seven hundred twenty-nine patients (72%) reached
a maximal dobutamine dose of 40 micrograms/kg/min. Dobutamine significantly
increased heart rate (76 +/- 14 beats/min to 127 +/- 20 beats/min; p < 0.001) and
systolic blood pressure (141 +/- 20 mm Hg to 168 +/- 36 mm Hg; p < 0.001) from
baseline to peak infusion rate. The most common side effects were chest pain (31%),
headache (14%), dyspnea (12%), palpitations (10%), and flushing (10%). There was no
death, myocardial infarction, pulmonary edema, ventricular fibrillation, sustained
ventricular tachycardia, or cerebral vascular accident. Nonsustained ventricular
tachycardia occurred in 43 patients (4.2%) but did not cause any hemodynamic
instability. CONCLUSIONS: When done with the necessary caution, dobutamine
myocardial perfusion imaging is a safe diagnostic test, although side effects are
common.
AD - Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
AN - 8902673
AU - Dakik, H. A.
AU - Vempathy, H.
AU - Verani, M. S.
DA - Sep-Oct
DO - 10.1016/s1071-3581(96)90076-8
DP - NLM
ET - 1996/09/01
IS - 5
J2 - Journal of nuclear cardiology : official publication of the American Society
of Nuclear Cardiology
KW - Aged
Aged, 80 and over
Angina Pectoris/chemically induced
Arrhythmias, Cardiac/chemically induced
Blood Pressure/drug effects
*Cardiotonic Agents/administration & dosage/adverse effects
Cohort Studies
Coronary Circulation
Coronary Disease/*diagnostic imaging/physiopathology
*Dobutamine/administration & dosage/adverse effects
Drug Tolerance
Dyspnea/chemically induced
Female
Flushing/chemically induced
Headache/chemically induced
Hemodynamics
Humans
Male
Middle Aged
Radiopharmaceuticals
Safety
Stress, Physiological/physiopathology
Systole
Tachycardia, Ventricular/chemically induced
Technetium Tc 99m Sestamibi
Thallium Radioisotopes
*Tomography, Emission-Computed, Single-Photon/methods
LA - eng
N1 - Dakik, H A
Vempathy, H
Verani, M S
Journal Article
United States
J Nucl Cardiol. 1996 Sep-Oct;3(5):410-4. doi: 10.1016/s1071-3581(96)90076-8.
PY - 1996
SN - 1071-3581 (Print)
1071-3581
SP - 410-4
ST - Tolerance, hemodynamic changes, and safety of dobutamine stress perfusion
imaging
T2 - J Nucl Cardiol
TI - Tolerance, hemodynamic changes, and safety of dobutamine stress perfusion
imaging
VL - 3
ID - 2990
ER -
TY - JOUR
AB - Patients with end stage liver disease (ESLD) have complex problems such as
cirrhotic cardiomyopathy, coronary artery disease, hepatopulmonary syndrome (HPS),
portopulmonary hypertension (POPH), hepatic encephalopathy, intracranial
hypertension, (ICP), left ventricular outflow tract obstruction (LVOTO), high Model
of end liver disease (MELD) scores, hyponatremia, and coagulopathies. The
anesthesia management for liver transplantation can be very complex, dynamic and
challenging. Anesthesia agents affect hepatic blood flow and anesthetic drug
distribution, metabolism and elimination maybe altered in end stage liver disease.
Other non-anesthetic agents such as nitric oxide, epoprosterenol, THAM, hypertonic
saline, fibrinogen concentrates, fresh frozen plasma, platelets, packed red blood
cells, recombinant plasminogen activator, calcium chloride, epinephrine etc. may
play a vital role in the perioperative management of these patients. Intraoperative
hemostasis and coagulation management can be very arduous as these patients may
bleed or be at risk for thrombosis. Monitoring modalities such as
Thromboelastography (TEG), Transcranial Doppler (TCD), Transesophageal
Echocardiography (TEE), Bispectral Index (BIS) and Optic Nerve Sheath Diameter
(ONSD) ultrasound play a significant role in various circumstances. Surgical
techniques include complete or partial occlusion of the inferior vena cava (IVC)
with or without use of venovenous bypass (VVBP) or portocaval shunts. Post
reperfusion syndrome (PRS) is a crucial event in this procedure, where patients may
experience arrhythmia and/or cardiac arrest. Anesthetic handling of this phase has
been recapitulated in detail. Provision of anesthesia services to the living liver
transplant donor and pain management has been outlined.
AD - Department of Anesthesiology, Icahn School of Medicine at Mount Sinai, 1428
Madison Ave, New York City, NY 10029. Electronic address: aparna.dalal@mssm.edu.
AN - 26118926
AU - Dalal, A.
DA - Jan
DO - 10.1016/j.trre.2015.05.003
DP - NLM
ET - 2015/06/30
IS - 1
J2 - Transplantation reviews (Orlando, Fla.)
KW - *Anesthesia
Anesthetics/*pharmacology
End Stage Liver Disease/complications/*surgery
Humans
*Liver Transplantation
LA - eng
N1 - 1557-9816
Dalal, Aparna
Journal Article
Review
United States
Transplant Rev (Orlando). 2016 Jan;30(1):51-60. doi: 10.1016/j.trre.2015.05.003.
Epub 2015 May 15.
PY - 2016
SN - 0955-470x
SP - 51-60
ST - Anesthesia for liver transplantation
T2 - Transplant Rev (Orlando)
TI - Anesthesia for liver transplantation
VL - 30
ID - 3122
ER -
TY - JOUR
AB - In 134 patients (age 41-74 years) with symptoms of a transient ischaemic
attack the authors made an ultrasonic dopplerometric examination of the main
arteries of the head and a rheoencephalographic examination using the method of
polygraphic recording with an ECG tracing II. st. 1. as well as in extreme position
of the head and neck. In the investigated group in seven subjects a severe disorder
of the cardiac rhythm was recorded with more than one third of ectopic ventricular
contractions. The authors elaborated criteria for the objective expression of the
impact of haemodynamic changes on the cerebral circulation. When doing so, they
took into account the number of inadequate ventricular contractions with a pulse
deficit in the periphery, the frequency of inadequate contractions and their
haemodynamic effect the consequence of which was reduction of the pulse volume and
slowing down of the blood flow. According to these criteria dysrhythmia was the
cause of cerebral ischaemia in 4.5% of all subjects included in the authors' group.
In the group of patients with a severe disorder of the cardiac rhythm dysrhythmia
was the cause of a transient ischaemic attack in 86% of the patients. Trespassing
of the ischaemic threshold is promoted also by a poorer blood supply in extreme
positions of the head and neck which may occur in everyday life or during sleep.
AD - Oddĕlení Funkcního Vysetrování OUNZ Vyskov.
AN - 8293441
AU - Danĕk, V.
AU - Valihrach, J.
DA - Dec 6
DP - NLM
ET - 1993/12/06
IS - 23
J2 - Casopis lekaru ceskych
KW - Adult
Aged
Arrhythmias, Cardiac/*complications/physiopathology
Electrocardiography
Humans
Ischemic Attack, Transient/*complications/physiopathology
Male
Middle Aged
LA - cze
N1 - Danĕk, V
Valihrach, J
English Abstract
Journal Article
Czech Republic
Cas Lek Cesk. 1993 Dec 6;132(23):715-8.
OP - Hypoperfuze mozku pri poruchách srdecního rytmu.
PY - 1993
SN - 0008-7335 (Print)
0008-7335
SP - 715-8
ST - [Hypoperfusion of the brain in cardiac rhythm disorders]
T2 - Cas Lek Cesk
TI - [Hypoperfusion of the brain in cardiac rhythm disorders]
VL - 132
ID - 2683
ER -
TY - JOUR
AB - Low rates of coronary heart disease was found in Greenland Eskimos and
Japanese who are exposed to a diet rich in fish oil. Suggested mechanisms for this
cardio-protective effect focused on the effects of n-3 fatty acids on eicosanoid
metabolism, inflammation, beta oxidation, endothelial dysfunction, cytokine growth
factors, and gene expression of adhesion molecules; But, none of these mechanisms
could adequately explain the beneficial actions of n-3 fatty acids. One attractive
suggestion is a direct cardiac effect of n-3 fatty acids on arrhythmogenesis. N-3
fatty acids can modify Na+ channels by directly binding to the channel proteins and
thus, prevent ischemia-induced ventricular fibrillation and sudden cardiac death.
Though this is an attractive explanation, there could be other actions as well. N-3
fatty acids can inhibit the synthesis and release of pro-inflammatory cytokines
such as tumor necrosis factoralpha (TNFalpha) and interleukin-1 (IL-1) and IL-2
that are released during the early course of ischemic heart disease. These
cytokines decrease myocardial contractility and induce myocardial damage, enhance
the production of free radicals, which can also suppress myocardial function.
Further, n-3 fatty acids can increase parasympathetic tone leading to an increase
in heart rate variability and thus, protect the myocardium against ventricular
arrhythmias. Increased parasympathetic tone and acetylcholine, the principle vagal
neurotransmitter, significantly attenuate the release of TNF, IL-1beta, IL-6 and
IL-18. Exercise enhances parasympathetic tone, and the production of anti-
inflammatory cytokine IL-10 which may explain the beneficial action of exercise in
the prevention of cardiovascular diseases and diabetes mellitus. TNFalpha has
neurotoxic actions, where as n-3 fatty acids are potent neuroprotectors and brain
is rich in these fatty acids. Based on this, it is suggested that the principle
mechanism of cardioprotective and neuroprotective action(s) of n-3 fatty acids can
be due to the suppression of TNFalpha and IL synthesis and release, modulation of
hypothalamic-pituitary-adrenal anti-inflammatory responses, and an increase in
acetylcholine release, the vagal neurotransmitter. Thus, there appears to be a
close interaction between the central nervous system, endocrine organs, cytokines,
exercise, and dietary n-3 fatty acids. This may explain why these fatty acids could
be of benefit in the management of conditions such as septicemia and septic shock,
Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, diabetes
mellitus, essential hypertension and atherosclerosis.
AD - EFA Sciences LLC, 1420 Providence Highway, Norwood, MA 02062, USA.
undurti@hotmail.com
AN - 11133172
AU - Das, U. N.
DA - Dec
DO - 10.1054/plef.2000.0226
DP - NLM
ET - 2001/01/03
IS - 6
J2 - Prostaglandins, leukotrienes, and essential fatty acids
KW - Acetylcholine/physiology
Animals
Arrhythmias, Cardiac/epidemiology/prevention & control
Brain/physiopathology
Cardiovascular Diseases/diet therapy/epidemiology/*prevention & control
Cell Adhesion Molecules/biosynthesis/genetics
Cell Division/drug effects
Cohort Studies
Cytokines/metabolism
Dietary Fats/administration & dosage/*pharmacology/therapeutic use
Eicosanoids/metabolism
Endothelium, Vascular/drug effects/metabolism
Exercise
Fatty Acids, Omega-3/administration & dosage/*pharmacology/therapeutic use
Fatty Acids, Unsaturated/metabolism
Fish Oils/administration & dosage/*pharmacology/therapeutic use
Gene Expression Regulation/drug effects
Greenland/epidemiology
Heart/drug effects
Hemostasis/drug effects
Humans
Hypothalamo-Hypophyseal System/drug effects/physiopathology
Inflammation/drug therapy/metabolism/prevention & control
Inuits
Japan/epidemiology
Lipid Metabolism
Models, Biological
Myocardium/metabolism
Oxidation-Reduction
Oxidative Stress
Parasympathetic Nervous System/drug effects
Pituitary-Adrenal System/drug effects/physiopathology
Rats
Sodium Channels/drug effects
Vagus Nerve/physiopathology
LA - eng
N1 - Das, U N
Journal Article
Review
Scotland
Prostaglandins Leukot Essent Fatty Acids. 2000 Dec;63(6):351-62. doi:
10.1054/plef.2000.0226.
PY - 2000
SN - 0952-3278 (Print)
0952-3278
SP - 351-62
ST - Beneficial effect(s) of n-3 fatty acids in cardiovascular diseases: but, why
and how?
T2 - Prostaglandins Leukot Essent Fatty Acids
TI - Beneficial effect(s) of n-3 fatty acids in cardiovascular diseases: but, why
and how?
VL - 63
ID - 3027
ER -
TY - JOUR
AB - Left triatrial heart is defined as division of the left atrium into two
chambers, proximal and distal, by a variably perforated membrane. The data of
appearance of symptoms, often in early childhood, is related to the degree of
obstruction and the presence or not of an inter-atrial shunt. Widescale usage of
echocardiography, the investigation of choice for this diagnosis, has led to the
detection of this abnormality in older patients, sometimes asymptomatic, without
pulmonary hypertension. Three adults were referred for transthoracic and
transoesophageal echocardiography to investigate systemic embolic disease (2
cerebral, 1 mesenteric). Two other adults underwent the same investigations for
diagnosis of the aetiology of atrial fibrillation with mitral regurgitation. Two
cases were asymptomatic children, one with a clinically benign murmur and the other
with ventricular extrasystoles with no malignant features. In these seven cases,
transthoracic (n = 5) and/or transoesophageal (n = 7) echocardiography demonstrated
a left atrial membrane corresponding to the classical description of cor triatrium.
The Doppler study showed no obstruction in 6 cases and minimal obstruction in 1
case. In our series, as in similar cases reported in the literature, the diagnosis
of a left atrial membrane did not lead to surgery. Although we do not know the
long-term outcome of this abnormality in asymptomatic children, the observations of
complications in the adult suggest a potential of evolution which poses the
question of optimal management.
AD - Service cardiologie, CHU hôpital G-Montpied, Clermont-Ferrand.
AN - 9749213
AU - Dauphin, C.
AU - Lusson, J. R.
AU - Motreff, P.
AU - Lorillard, R.
AU - Justin, E. P.
AU - Briand, F.
AU - Valy, Y.
AU - Lamaison, D.
AU - Chabrun, A.
AU - Cassagnes, J.
DA - May
DP - NLM
ET - 1998/09/28
IS - 5
KW - Adult
Child
*Cor Triatriatum/diagnostic imaging/physiopathology
Female
Humans
Male
LA - fre
N1 - Dauphin, C
Lusson, J R
Motreff, P
Lorillard, R
Justin, E P
Briand, F
Valy, Y
Lamaison, D
Chabrun, A
Cassagnes, J
Journal Article
Review
France
Arch Mal Coeur Vaiss. 1998 May;91(5):615-21.
OP - Membrane intra-auriculaire gauche sans obstruction veineuse pulmonaire:
pathologie bénigne ou évolutive? A propos de 7 observations.
PY - 1998
SN - 0003-9683 (Print)
0003-9683
SP - 615-21
ST - [Left intra-atrial membrane without pulmonary vein obstruction: benign
condition of progressive evolution? Apropos of 7 cases]
TI - [Left intra-atrial membrane without pulmonary vein obstruction: benign
condition of progressive evolution? Apropos of 7 cases]
VL - 91
ID - 3143
ER -
TY - JOUR
AB - This study analyzes the natural history of a large cohort of probands with
Brugada syndrome (BrS) to assess the predictive value of different clinical and
electrocardiographic parameters for the development of ventricular fibrillation
(VF) or sudden cardiac death (SCD) during a long-term follow-up. Baseline
characteristics of 289 consecutive probands (203 men; mean age 45 ± 16 years) with
a Brugada type 1 electrocardiogram were analyzed. After a mean follow-up of 10.1 ±
4.6 years, 29 malignant arrhythmias occurred. On multivariate analysis, a history
of VF and syncopal episodes, fragmented QRS (f-QRS), spontaneous type 1
electrocardiogram, and early repolarization pattern were significantly associated
with later occurrence of VF/SCD. In patients with drug-induced BrS, the
accentuation or de novo appearance of f-QRS in other leads was always associated
with VF/SCD. Cerebrovascular events occurred in 8 patients with atrial fibrillation
(15.1%), most of them (75%) presenting as the first clinical manifestation. The
time-to-diagnosis was found to be significantly shorter in those patients who
directly came to our center than in those who referred to our center for a second
opinion. In conclusion, systematic use of the pharmacologic challenge in patients
with unexplained cardiovascular symptoms and/or atrial fibrillation might
significantly improve the identification of BrS with a shortening of the time-to-
diagnosis. The CHA(2)DS(2)VASc score might be inappropriate for predicting
transient ischemic attack or stroke in BrS. This study confirms the independent
predictive value of previous VF and syncopal episodes, f-QRS, type 1
electrocardiogram, and early repolarization pattern. In BrS a sufficiently long
follow-up is necessary before conclusions on prognosis are apparent.
AD - Cardiovascular Department, Heart Rhythm Management Center, Postgraduate
Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel,
Vrije Universiteit Brussel, Brussels, Belgium. Electronic address:
carlodeasmundis@me.com.
Cardiovascular Department, Heart Rhythm Management Center, Postgraduate Program in
Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel, Vrije
Universiteit Brussel, Brussels, Belgium.
Cardiac Surgery Department, Universitair Ziekenhuis Brussel, Vrije Universiteit
Brussel, Brussels, Belgium.
AN - 28274576
AU - de Asmundis, C.
AU - Mugnai, G.
AU - Chierchia, G. B.
AU - Sieira, J.
AU - Conte, G.
AU - Rodriguez-Mañero, M.
AU - Pappaert, G.
AU - Czapla, J.
AU - Nijs, J.
AU - La Meir, M.
AU - Casado, R.
AU - Ströker, E.
AU - De Regibus, V.
AU - Brugada, P.
DA - May 1
DO - 10.1016/j.amjcard.2017.01.039
DP - NLM
ET - 2017/03/10
IS - 9
KW - Adult
Aged
Belgium/epidemiology
Brugada Syndrome/diagnosis/*epidemiology/physiopathology/therapy
Death, Sudden, Cardiac/*epidemiology/prevention & control
Delayed Diagnosis
Electrocardiography
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prospective Studies
Risk Assessment
Ventricular Fibrillation/*epidemiology
LA - eng
N1 - 1879-1913
de Asmundis, Carlo
Mugnai, Giacomo
Chierchia, Gian-Battista
Sieira, Juan
Conte, Giulio
Rodriguez-Mañero, Moises
Pappaert, Gudrun
Czapla, Jens
Nijs, Jan
La Meir, Mark
Casado, Ruben
Ströker, Erwin
De Regibus, Valentina
Brugada, Pedro
Journal Article
United States
Am J Cardiol. 2017 May 1;119(9):1392-1400. doi: 10.1016/j.amjcard.2017.01.039. Epub
2017 Feb 10.
PY - 2017
SN - 0002-9149
SP - 1392-1400
ST - Long-Term Follow-Up of Probands With Brugada Syndrome
T2 - Am J Cardiol
TI - Long-Term Follow-Up of Probands With Brugada Syndrome
VL - 119
ID - 2354
ER -
TY - JOUR
AB - OBJECTIVE: To investigate the detection rate of cardiac sources of embolism
by transoesophageal echocardiography in patients with focal cerebral ischaemic
events and to relate the echocardiographic findings to other clinical findings.
DESIGN: Prospective study with blinded analysis of the echocardiographic data and
subsequent comparison with the other clinical findings. SETTING: Regional
cardiothoracic unit based in a teaching hospital. PATIENTS: 131 consecutive
patients with focal ischaemic cerebral events (49 with a transient ischaemic
attack, 77 with a cerebrovascular accident, and five with a retinal arterial
embolus) referred for echocardiography. INTERVENTIONS: Full M mode, cross
sectional, Doppler, and contrast echocardiography by both the precordial and
transoesophageal techniques. RESULTS: Precordial echocardiography detected a
cardiac abnormality in 72 patients. Transoesophageal echocardiography confirmed all
the precordial findings (except left ventricular hypertrophy, which at present
cannot be defined with this technique) and detected other abnormalities in a
further 20 patients (18 with potential right-to-left shunts and two with valve
vegetations). It also showed spontaneous contrast echoes in 27 of 28 patients with
a large left atrium and showed atrial thrombus in three. Cardiac abnormalities were
clinically detected in 53 patients, all of which were confirmed or documented by
echocardiography. In the 78 patients with no clinically detectable cardiac
abnormality six had mitral valve prolapse and one had a regional wall motion defect
(identified by precordial echocardiography) and 17 had potential right-to-left
shunts (11 of which were identified only by transoesophageal echocardiography).
CONCLUSIONS: Transoesophageal echocardiography is more sensitive than precordial
echocardiography in detecting potential sources of embolism in these patients.
However, except for the detection of a potential right-to-left shunt, the yield in
patients with no cardiac abnormality is low. Moreover, the abnormalities detected
in those with previously detected cardiac disease merely confirm the clinical
diagnosis. Patients with left atrial spontaneous contrast echoes may benefit from
anticoagulation but this requires further study. Until more data are available on
this feature and on the role of potential right-to-left shunts in this population,
the contribution of echocardiography, precordial or transoesophageal, remains
limited.
AD - Department of Cardiological Sciences, St George's Hospital Medical School,
London.
AN - 1389703
AU - de Belder, M. A.
AU - Lovat, L. B.
AU - Tourikis, L.
AU - Leech, G.
AU - Camm, A. J.
C2 - PMC1024836
DA - Apr
DO - 10.1136/hrt.67.4.297
DP - NLM
ET - 1992/04/01
IS - 4
J2 - British heart journal
KW - Adult
Aged
Aged, 80 and over
Atrial Fibrillation/diagnostic imaging
Embolism/*complications/diagnostic imaging
Esophagus
Female
Heart Diseases/*complications/*diagnostic imaging
Heart Valve Diseases/diagnostic imaging
Humans
Male
Middle Aged
Mitral Valve/diagnostic imaging
Prospective Studies
Risk Factors
Single-Blind Method
LA - eng
N1 - de Belder, M A
Lovat, L B
Tourikis, L
Leech, G
Camm, A J
Clinical Trial
Controlled Clinical Trial
Journal Article
Br Heart J. 1992 Apr;67(4):297-303. doi: 10.1136/hrt.67.4.297.
PY - 1992
SN - 0007-0769 (Print)
0007-0769
SP - 297-303
ST - Limitations of transoesophageal echocardiography in patients with focal
cerebral ischaemic events
T2 - Br Heart J
TI - Limitations of transoesophageal echocardiography in patients with focal
cerebral ischaemic events
VL - 67
ID - 3016
ER -
TY - JOUR
AB - BACKGROUND: The 2 fundamental approaches to the management of atrial
fibrillation (AF) are reestablishing and maintaining sinus rhythm (rhythm control)
and controlling ventricular rate with atrioventricular node blocking agents (rate
control). We performed a meta-analysis of randomized controlled trials comparing
these strategies in patients with AF to add precision to the relative merits of
both strategies on the risk of all-cause mortality and to evaluate the consistency
of the results between trials. METHODS: We performed a literature search in MEDLINE
(1966 to May 2003), the Cochrane Controlled Trial Registry (first quarter of 2003),
and International Pharmaceutical Abstracts (1970 to May 2003). Eligible trials were
randomized controlled trials comparing pharmacologic rhythm and rate control
strategies as first-line therapy in patients with AF. RESULTS: Five trials were
identified that included a total of 5,239 patients with persistent AF or AF that
was considered likely to be recurrent. No significant difference was observed
between the rate and the rhythm control groups regarding all-cause mortality,
although a strong trend in favor of a rate control approach was observed (13.0% vs
14.6%; odds ratio, 0.87; 95% confidence interval, 0.74-1.02; P=.09). No
heterogeneity was apparent between the trials (Q value=2.97; P=.56). CONCLUSIONS:
In patients with persistent AF or with AF that is likely to be recurrent, a
strategy of ventricular rate control, in combination with anticoagulation in
appropriate patients, appears to be at least equivalent to a strategy of
maintaining sinus rhythm by using currently available antiarrhythmic drugs in
preventing clinical outcomes.
AD - Pharmacy Department, Montreal Heart Institute/Faculty of Pharmacy, University
of Montreal, Montreal, Quebec.
AN - 15710787
AU - de Denus, S.
AU - Sanoski, C. A.
AU - Carlsson, J.
AU - Opolski, G.
AU - Spinler, S. A.
DA - Feb 14
DO - 10.1001/archinte.165.3.258
DP - NLM
ET - 2005/02/16
IS - 3
J2 - Archives of internal medicine
KW - Aged
Female
*Heart Rate
Humans
Male
Odds Ratio
Recurrence
LA - eng
N1 - de Denus, Simon
Sanoski, Cynthia A
Carlsson, Jörg
Opolski, Grzegorz
Spinler, Sarah A
Comparative Study
Journal Article
Meta-Analysis
Review
United States
Arch Intern Med. 2005 Feb 14;165(3):258-62. doi: 10.1001/archinte.165.3.258.
PY - 2005
SN - 0003-9926 (Print)
0003-9926
SP - 258-62
ST - Rate vs rhythm control in patients with atrial fibrillation: a meta-analysis
T2 - Arch Intern Med
TI - Rate vs rhythm control in patients with atrial fibrillation: a meta-analysis
VL - 165
ID - 2636
ER -
TY - JOUR
AB - BACKGROUND: The annual stroke rate in atrial fibrillation is around 5 per
cent with increased risk in those with hypertension, diabetes, left ventricular
dysfunction and other cardiovascular risk factors. This study set out to identify
the patients with atrial fibrillation and modifiable risk factors for stroke.
METHOD: Analysis of practice computer data taken from eight general practices (81
811 patients) in the south of England. 944 patients with a diagnosis of atrial
fibrillation, of whom 782 (82.8 percent) were aged 65 years and over. RESULTS: The
age standardised prevalence of diagnosed atrial fibrillation was 1.23 per cent
(1.28 percent for men and 1.18 percent for women). It was much more prevalent in
the older population, 8.28 percent and 6.66 percent for males and females over 65,
respectively. Cardiovascular co-morbidities were more frequent with increasing age.
Blood pressure (BP) was recorded in over 95 per cent of patients with atrial
fibrillation though there was scope for improving control; 25 per cent of men and
31 per cent women had a BP over 150/90. Inconsistent recording of ECG and
echocardiography made it hard to identify patients with left ventricular
dysfunction. Forty six percent of men and 37 percent of women were either being
prescribed Warfarin, or had contraindications to its use; of those on Warfarin 75.9
percent have an international normalized ratio in range. Forty four per cent were
treated with aspirin. People at high risk of stroke were no more likely to be
treated with Warfarin or aspirin than those at moderate risk. CONCLUSIONS: The rate
of use of Warfarin remains low, and there is scope for better recording and
management of risk factors particularly BP.
AD - Primary Care Informatics, Department of Community Health Sciences, St
George's Hospital Medical School, London SW17 ORE, UK. slusigna@sghms.ac.uk
AN - 15590708
AU - de Lusignan, S.
AU - van Vlymen, J.
AU - Hague, N.
AU - Thana, L.
AU - Dzregah, B.
AU - Chan, T.
DA - Mar
DO - 10.1093/pubmed/fdh201
DP - NLM
ET - 2004/12/14
IS - 1
J2 - Journal of public health (Oxford, England)
KW - Adult
Age Factors
Aged
Aged, 80 and over
Anticoagulants/administration & dosage/therapeutic use
Atrial Fibrillation/*complications/epidemiology
Comorbidity
Diabetes Complications/epidemiology
England/epidemiology
Family Practice/*statistics & numerical data
Female
Humans
Male
Middle Aged
Prevalence
Risk Assessment
Risk Factors
Sex Distribution
Stroke/*epidemiology/etiology/*prevention & control
Wales/epidemiology
Warfarin/administration & dosage/therapeutic use
LA - eng
N1 - de Lusignan, Simon
van Vlymen, Jeremy
Hague, Nigel
Thana, Lavanya
Dzregah, Billy
Chan, Tom
Comparative Study
Journal Article
England
J Public Health (Oxf). 2005 Mar;27(1):85-92. doi: 10.1093/pubmed/fdh201. Epub 2004
Dec 8.
PY - 2005
SN - 1741-3842 (Print)
1741-3842
SP - 85-92
ST - Preventing stroke in people with atrial fibrillation: a cross-sectional study
T2 - J Public Health (Oxf)
TI - Preventing stroke in people with atrial fibrillation: a cross-sectional study
VL - 27
ID - 2649
ER -
TY - JOUR
AB - BACKGROUND: Butane gas is inhaled by young people with the aim of getting
'high'. This can cause coronary spasm with myocardial infarction and ventricular
fibrillation as a result. CASE DESCRIPTION: We report on a 16-year-old male who
collapsed at home after sniffing butane. His father, together with a paramedical
emergency team that had found ventricular fibrillation, started basic and advanced
life support. ECG showed exaggerated ST-elevations and an echocardiography showed a
hypokinetic anterior ventricular wall and ventricular septum. After treatment with
dobutamine, nitroglycerine, acetylsalicylic acid and dalteparine, the ECG and left
ventricular function improved. He was admitted to a pediatric intensive care unit
where he was artificially ventilated for 4 days and treated for cardiogenic shock.
In the following days his cardiovascular condition improved. Magnetic resonance
imaging showed no ischaemic damage of the brain. At 6 weeks his general condition
was not as before, but ECG and cardiac function had almost recovered. CONCLUSION:
Young people who experiment with inhalation of volatile substances generally do not
know how dangerous this is. Provision of information about the possible
consequences will have a preventive effect.
AD - Franciscus Ziekenhuis, Roosendaal, Afd. Kindergeneeskunde, the Netherlands.
AN - 21871141
AU - De Naeyer, A. H.
AU - de Kort, S. W.
AU - Portegies, M. C.
AU - Deraedt, D. J.
AU - Buysse, C. M.
DP - NLM
ET - 2011/08/30
IS - 34
J2 - Nederlands tijdschrift voor geneeskunde
KW - Administration, Inhalation
Adolescent
Butanes/*administration & dosage/*adverse effects
Electrocardiography
Humans
Male
Myocardial Infarction/*chemically induced/therapy
Respiration, Artificial
Spasm/chemically induced/therapy
Substance-Related Disorders
Treatment Outcome
Ventricular Fibrillation/chemically induced/therapy
LA - dut
N1 - 1876-8784
De Naeyer, Ann H R R
de Kort, Sandra W K
Portegies, Mireille C M
Deraedt, Dirk J D L
Buysse, Corinne M P
Case Reports
English Abstract
Journal Article
Netherlands
Ned Tijdschr Geneeskd. 2011;155(34):A3443.
OP - Myocardinfarct bij een 16-jarige na inhalatie van butaangas.
PY - 2011
SN - 0028-2162
SP - A3443
ST - [Myocardial infarction in a 16-year old following inhalation of butane gas]
T2 - Ned Tijdschr Geneeskd
TI - [Myocardial infarction in a 16-year old following inhalation of butane gas]
VL - 155
ID - 2942
ER -
TY - JOUR
AB - Prevalence of obesity, metabolic syndrome (MetS) and type 2 diabetes (T2D) is
growing alarmingly, and the number of affected people continues to escalate. Such
cardiometabolic states exert many deleterious effects on the heart as they are
associated with adverse left ventricular (LV) remodeling and, most notably, with a
marked increase in the risk of developing atrial fibrillation (AF) and subsequent
stroke. Epidemiological studies clearly show a strong association between obesity
and AF, with a 4-5% increase in AF risk for every unit increase in BMI. The
increased risk of developing AF in cardiometabolic patients is explained by changes
in volume status, energy substrate utilization, tissue metabolism and systemic
inflammation, all factors promoting elevation in left atrial and systolic blood
pressure, LV systo-diastolic dysfunction, with subsequent atrial stretch and
"triggers" for AF. In the present review, we critically discuss available evidence
on AF risk in the cardiometabolic patient. Specific aspects will be discussed: 1)
epidemiology and prognosis of AF in patients with obesity, MetS and T2D; 2)
molecular mechanisms involved in the pathophysiology of metabolic cardiomyopathy
and left atrial remodeling; 3) advances in medical therapy including weight loss
strategies and lifestyle changes; 4) new oral anticoagulants and stroke risk in
obese and diabetic patients; 5) effectiveness and safety of AF catheter ablation.
Taken together, these novel insights point to the development of new therapeutic
strategies to combat the burden of AF in patients with cardiometabolic
disturbances.
AD - Unit of Electrophysiology, Department of Cardiology, Misericordia Hospital,
Grosseto, Italy.
Center for Molecular Cardiology, University of Zürich, Zürich, Switzerland.
Center for Molecular Cardiology, University of Zürich, Zürich, Switzerland -
francesco.paneni@uzh.ch.
Unit of Cardiology, University Heart Center, University Hospital Zürich, Zürich,
Switzerland.
AN - 30371045
AU - De Sensi, F.
AU - Costantino, S.
AU - Limbruno, U.
AU - Paneni, F.
DA - Apr
DO - 10.23736/s0026-4806.18.05882-2
DP - NLM
ET - 2018/10/30
IS - 2
J2 - Minerva medica
Atrial Fibrillation/epidemiology/*etiology/therapy
Atrial Remodeling
Catheter Ablation
Diabetes Mellitus, Type 2/*complications/therapy
Exercise
Humans
Life Style
Metabolic Syndrome/*complications/therapy
Obesity/*complications/therapy
Prognosis
Thromboembolism/prevention & control
Weight Loss
LA - eng
N1 - 1827-1669
De Sensi, Francesco
Costantino, Sarah
Limbruno, Ugo
Paneni, Francesco
Journal Article
Review
Italy
Minerva Med. 2019 Apr;110(2):157-167. doi: 10.23736/S0026-4806.18.05882-2. Epub
2018 Oct 29.
PY - 2019
SN - 0026-4806
SP - 157-167
ST - Atrial fibrillation in the cardiometabolic patient
T2 - Minerva Med
TI - Atrial fibrillation in the cardiometabolic patient
VL - 110
ID - 2295
ER -
TY - JOUR
AB - BACKGROUND: Transcatheter ablation (Abl) of atrial fibrillation (AF) is
regarded as the best therapeutic solution for severely symptomatic patients, in
whom at least one antiarrhythmic drug has been tested. METHODS: In the present
retrospective study, 175 cases of paroxysmal, persistent or long-lasting persistent
AF have been gathered, and grouped depending on therapeutic approach: Abl, isolated
or followed by chronic use of antiarrhythmics (N.=74), drug treatment for rate
control strategy (N.=60), and drug treatment for rhythm control strategy (N.=41).
The effects respectively exerted by the three treatment modalities on the primary
endpoint, namely a composite of death, disabling stroke, severe bleeding and
cardiac arrest, have been compared through a median follow-up of 20 months
(interquartile range: 18-24 months) using the Cox proportional-hazards regression
analysis. Further exposure variables were hypertension, the A-P diameter of the
left atrium, the left ventricular ejection fraction and AF relapses. RESULTS: The
rhythm control strategy and AF recurrences during the follow-up were associated
with increased risk of the primary composite endpoint as documented by the Cox
model (for the former, hazard ratio [HR]: 3.3159; 95% CI: 1.5415 to 7.1329;
P=0.0023; for the latter, HR: 1.0448; 95% CI: 1.0020 to 1.0895; P=0.0410). Even
hypertension was associated with an increased risk (HR: 1.1040; 95% CI: 1.0112 to
1.9662; P=0.0477). On the contrary, a rate control strategy predicted a decreased
risk of experiencing the primary endpoint (HR: 0.0711; 95% CI: 0.0135 to 0.3738;
P=0.0019) while Abl did not exert a statistically significant effect on the same
outcome. CONCLUSIONS: AF ablation is able to decrease the arrhythmic episodes but
does not offer a statistically significant protection against the composite of
death, disabling stroke, severe bleeding and cardiac arrest in the mid-term follow-
up.
AD - Preventive Cardiology and Rehabilitation Unit, S. Gennaro dei Poveri
Hospital, Naples, Italy - devecchis.erre@virgilio.it.
Preventive Cardiology and Rehabilitation Unit, S. Gennaro dei Poveri Hospital,
Naples, Italy.
AN - 31115243
AU - De Vecchis, R.
AU - Soreca, S.
AU - Ariano, C.
DA - Aug
DO - 10.23736/s0026-4725.19.04877-1
DP - NLM
ET - 2019/05/23
IS - 4
J2 - Minerva cardioangiologica
KW - Aged
Anti-Arrhythmia Agents/*administration & dosage
Atrial Fibrillation/complications/physiopathology/*surgery
Female
Follow-Up Studies
Humans
Male
Middle Aged
Recurrence
Treatment Outcome
LA - eng
N1 - 1827-1618
De Vecchis, Renato
Soreca, Silvia
Ariano, Carmelina
Journal Article
Italy
Minerva Cardioangiol. 2019 Aug;67(4):272-279. doi: 10.23736/S0026-4725.19.04877-1.
Epub 2019 May 20.
PY - 2019
SN - 0026-4725
SP - 272-279
ST - Ablation, rate or rhythm control strategies for patients with atrial
fibrillation: how do they affect mid-term clinical outcomes?
T2 - Minerva Cardioangiol
TI - Ablation, rate or rhythm control strategies for patients with atrial
fibrillation: how do they affect mid-term clinical outcomes?
VL - 67
ID - 2417
ER -
TY - JOUR
AB - Due to its protective effect on the brain and the myocardium, hypothermia
therapy (HT) has been extensively studied in cardiac arrest patients with coma as
well as in patients presenting with acute myocardial infarction (MI). In the
setting of cardiac arrest, randomized studies have shown that HT decreases
mortality and improves neurological outcomes. Subsequent guidelines have therefore
recommended cooling (32°C to 34°C) for 12 to 24 h in unconscious adult patients
with spontaneous circulation after out-of-hospital cardiac arrest due to
ventricular fibrillation. Observational studies have also confirmed the feasibility
of this therapy in clinical practice and support its early application in patients
with nonventricular fibrillation cardiac arrest and in post-resuscitation
circulatory shock. In patients with acute MI, available clinical evidence does not
yet support HT as the standard of care, because no study to date has shown a clear
net benefit in such a cohort. After a brief review of the mechanisms of action for
HT, we provide a review of the clinical evidence, cooling techniques, and potential
adverse effects associated with HT in the setting of post-cardiac arrest patient
and acute MI.
AD - Department of Internal Medicine, Division of Cardiology, Washington Hospital
Center, 110 Irving Street, Washington, DC 20010, USA.
AN - 22240124
AU - Delhaye, C.
AU - Mahmoudi, M.
AU - Waksman, R.
DA - Jan 17
DO - 10.1016/j.jacc.2011.06.077
DP - NLM
ET - 2012/01/14
IS - 3
KW - Animals
Heart Arrest/epidemiology/physiopathology/*therapy
Humans
Hypothermia, Induced/*methods
Myocardial Infarction/epidemiology/physiopathology/*therapy
Nervous System Diseases/epidemiology/physiopathology/prevention & control
Randomized Controlled Trials as Topic/methods
Ventricular Fibrillation/epidemiology/physiopathology/therapy
LA - eng
N1 - 1558-3597
Delhaye, Cédric
Mahmoudi, Michael
Waksman, Ron
Journal Article
Review
United States
J Am Coll Cardiol. 2012 Jan 17;59(3):197-210. doi: 10.1016/j.jacc.2011.06.077.
PY - 2012
SN - 0735-1097
SP - 197-210
ST - Hypothermia therapy: neurological and cardiac benefits
TI - Hypothermia therapy: neurological and cardiac benefits
VL - 59
ID - 2926
ER -
TY - JOUR
AN - 14179514
AU - Devega, N. G.
AU - Urquia, M.
AU - Alvarezdiaz, F.
AU - Derabago, G.
DA - May-Jun
DP - NLM
ET - 1964/05/01
J2 - Bulletin de la Societe internationale de chirurgie
KW - *Aortic Valve Stenosis
*Heart, Artificial
*Hemorrhage
*Intracranial Embolism
*Intracranial Embolism and Thrombosis
*Mitral Valve Stenosis
*Thoracic Surgery
*cerebral embolism and thrombosis
*heart surgery
*heart, mechanical
LA - spa
N1 - Devega, n g
Urquia, m
Alvarezdiaz, f
Derabago, g
Journal Article
Belgium
Bull Soc Int Chir. 1964 May-Jun;23:320-5.
OP - Cirugia y resultados de la estenosis a'ortica.
PY - 1964
SN - 0037-945X (Print)
0037-945x
SP - 320-5
ST - [SURGICAL TREATMENT AND ITS RESULTS IN AORTIC STENOSIS]
T2 - Bull Soc Int Chir
TI - [SURGICAL TREATMENT AND ITS RESULTS IN AORTIC STENOSIS]
VL - 23
ID - 2850
ER -
TY - JOUR
AB - INTRODUCTION: The Losartan Intervention For Endpoint reduction in
hypertension (LIFE) study is the first, and, so far, the only endpoint trial in
patients with hypertension and left ventricular hypertrophy (LVH) to show a
divergent therapeutic outcome of one treatment modality over another with
equivalent blood pressure control. The purpose of this article is to review post
hoc sub-analyses of LIFE study data and other clinical studies that offer some
insight into possible treatment-related differences contributing to the superior
stroke outcome of losartan versus atenolol beyond blood pressure reduction.
METHODS: Relevant randomized clinical trials and review articles were identified
through a MEDLINE search of English-language articles published between 1990 and
2006 using the search terms losartan, atenolol, LIFE, hypertension, and LVH.
Articles describing major clinical studies, new data, or mechanisms pertinent to
the LIFE study were selected for review. RESULTS: Differences in blood pressure or
in the distribution of add-on medications were not evident between study groups in
the LIFE study. Thus, the observed outcomes benefits favoring losartan may involve
other possible mechanisms, including differential effects of losartan and atenolol
on LVH regression, left atrial diameter, atrial fibrillation, brain natriuretic
peptide, vascular structure, thrombus formation/platelet aggregation, serum uric
acid, albuminuria, new-onset diabetes, and lipid metabolism. Alternative
explanations for the LIFE study findings have also been put forward, including the
choice of atenolol as an appropriate active comparator and differential effects
between treatment groups on central pulse pressure. Additional clinical trials are
needed to determine if the beneficial effects of losartan seen in LIFE are shared
by other inhibitors of the renin-angiotensin system. CONCLUSION: Sub-analyses of
the LIFE study data suggest that losartan's stroke benefit may arise from a mosaic
of mechanisms rather than a single action. Further studies are expected to continue
to delineate the mechanisms of differential responses to treatments in LIFE.
AD - Greenberg Division of Cardiology, Weill Medical College of Cornell
University, New York, NY 10021, USA. rbdevere@med.cornell.edu
AN - 17288698
AU - Devereux, R. B.
AU - Dahlöf, B.
DA - Feb
DO - 10.1185/030079906x167435
DP - NLM
ET - 2007/02/10
IS - 2
J2 - Current medical research and opinion
KW - Adrenergic beta-Antagonists/pharmacology/therapeutic use
Angiotensin II Type 1 Receptor Blockers/pharmacology/*therapeutic use
Antihypertensive Agents/pharmacology/*therapeutic use
Atenolol/pharmacology/therapeutic use
Atrial Fibrillation/epidemiology/prevention & control
Atrial Natriuretic Factor/blood
Biomarkers
Cohort Studies
Drug Utilization
Endothelium, Vascular/physiopathology
Follow-Up Studies
Heart Atria/pathology
Humans
Hypertension/complications/*drug therapy
Hypertrophy, Left Ventricular/complications/*drug therapy
Losartan/pharmacology/*therapeutic use
Models, Biological
Myocardial Infarction/epidemiology/prevention & control
Peptide Fragments/blood
Platelet Aggregation/drug effects
Platelet Aggregation Inhibitors/pharmacology/*therapeutic use
Protein Precursors/blood
Randomized Controlled Trials as Topic/statistics & numerical data
Research Design
Risk
Risk Factors
Thrombosis/prevention & control
Treatment Outcome
LA - eng
N1 - 1473-4877
Devereux, Richard B
Dahlöf, Björn
Comparative Study
Journal Article
Review
England
Curr Med Res Opin. 2007 Feb;23(2):443-57. doi: 10.1185/030079906X167435.
PY - 2007
SN - 0300-7995
SP - 443-57
ST - Potential mechanisms of stroke benefit favoring losartan in the Losartan
Intervention For Endpoint reduction in hypertension (LIFE) study
T2 - Curr Med Res Opin
TI - Potential mechanisms of stroke benefit favoring losartan in the Losartan
Intervention For Endpoint reduction in hypertension (LIFE) study
VL - 23
ID - 2872
ER -
TY - JOUR
AB - Atrial fibrillation (AF) is the most common type of arrhythmia, which
undermines cardiac function. Atrial fibrillation is a multi-facet malady and it may
occur as a result of other diseases or it may trigger other problems. One of the
main complications of AF is stroke due to the possibility of clot formation inside
the atrium. However, the possibility of stroke occurrence due to the AF and the
location from which an embolus dispatches are subject of debate. Another hypothesis
about the embolus formation during AF is thrombus formation in aorta and carotid
arteries, embolus detachment and its movement. To investigate the possibility of
the latter postulation, the current work suggests a parametric study to quantify
the sensitivity of aortic flow to four common AF traits including lack of atrial
kick, atrial remodelling, left ventricle systolic dysfunction, and high frequency
fibrillation. The simulation was carried out by coupling several in-house codes and
ANSYS-CFX module. The results reveal that AF traits lower flow rate at left
ventricular outflow tract, which in general lowers blood perfusion to systemic,
cerebral and coronary circulations. Consequently, it leads to endothelial cell
activation potential (ECAP) increase and variation of flow structure that both
suggest predisposed areas to atherogenesis and thrombus formation in different
regions in ascending aorta, aortic arch and descending thoracic aorta.
AD - Department of Mechanical, Aerospace and Civil Engineering (MACE), The
University of Manchester, Manchester, M13 9PL, UK.
Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of
Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PL,
UK.
Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of
Biology, Medicine and Health, University of Manchester, Manchester Academic Health
Science Centre, Oxford Road, Manchester, M13 9PL, UK.
Manchester University NHS Foundation Trust, Manchester Academic Health Science
Centre, Southmoor Road, Wythenshawe, Manchester, M13 9PL, UK.
Wellcome Centre for Cell-Matrix Research, Division of Cell-Matrix Biology &
Regenerative Medicine, School of Biology, Faculty of Biology, Medicine and Health,
University of Manchester, Manchester Academic Health Science Centre, Oxford Road,
Manchester, M13 9PL, UK.
Department of Mechanical, Aerospace and Civil Engineering (MACE), The University of
Manchester, Manchester, M13 9PL, UK. a.keshmiri@manchester.ac.uk.
AN - 31938982
AU - Deyranlou, A.
AU - Naish, J. H.
AU - Miller, C. A.
AU - Revell, A.
AU - Keshmiri, A.
C2 - PMC7089914
DA - Apr
DO - 10.1007/s10439-020-02448-6
DP - NLM
ET - 2020/01/16
IS - 4
J2 - Annals of biomedical engineering
KW - 4D phase contrast magnetic resonance imaging
Aorta
Atrial fibrillation
Computational fluid dynamics
LA - eng
N1 - 1573-9686
Deyranlou, Amin
Naish, Josephine H
Miller, Christopher A
Revell, Alistair
Keshmiri, Amir
Orcid: 0000-0003-4747-277x
FS/17/47/32805/BHF_/British Heart Foundation/United Kingdom
Journal Article
Ann Biomed Eng. 2020 Apr;48(4):1291-1308. doi: 10.1007/s10439-020-02448-6. Epub
2020 Jan 14.
PY - 2020
SN - 0090-6964 (Print)
0090-6964
SP - 1291-1308
ST - Numerical Study of Atrial Fibrillation Effects on Flow Distribution in Aortic
Circulation
T2 - Ann Biomed Eng
TI - Numerical Study of Atrial Fibrillation Effects on Flow Distribution in Aortic
Circulation
VL - 48
ID - 3102
ER -
TY - JOUR
AB - Plasma levels of brain natriuretic peptide (BNP) are frequently elevated
after an acute stroke and have been shown to be an independent predictor of
mortality. However, the relationships between stroke and BNP concentrations have
not yet been systematically investigated. Plasma BNP assay and echocardiography
were performed in 48 patients with ischemic stroke or TIA with a mean delay of 12.7
h after onset. Median BNP concentration was 88.6 pg/mL (range 5-1270). Older age,
chronic heart failure, atrial fibrillation, stroke severity, lower hemoglobin
levels, lower left ventricular ejection fraction, and abnormalities of left atrium
or appendage (LA/LAA) were univariately associated with increased BNP levels. At
multivariable analysis, the presence of at least one LA/LAA abnormality (atrial
dilatation, low flow velocity, spontaneous echocontrast or thrombus) had the
strongest association with BNP, explaining 38.9% of the variance in the whole
sample and 28.5% in patients without atrial fibrillation. In acute ischemic stroke
patients, elevated plasma BNP levels have multiple determinants, among which left
atrial disease appears to be the stronger, even in patients without atrial
fibrillation. These results encourage further investigation of plasma BNP
concentration as a potential marker of the presence of left atrial sources of
emboli.
AD - Department of Neurological Sciences, University of Rome La Sapienza, Italy.
AN - 17512951
AU - Di Angelantonio, E.
AU - De Castro, S.
AU - Toni, D.
AU - Sacchetti, M. L.
AU - Biraschi, F.
AU - Prencipe, M.
AU - Fiorelli, M.
DA - Sep 15
DO - 10.1016/j.jns.2007.04.018
DP - NLM
ET - 2007/05/22
IS - 1-2
KW - Acute Disease
Aged
Aged, 80 and over
Atrial Fibrillation/complications/diagnostic imaging/physiopathology
Biomarkers/analysis/blood
Brain/blood supply/metabolism/physiopathology
Brain Ischemia/*blood/physiopathology
Echocardiography
Female
Heart/physiopathology
Heart Failure/*complications/diagnostic imaging/physiopathology
Humans
Intracranial Embolism/blood/etiology/physiopathology
Ischemic Attack, Transient/*blood/physiopathology
Male
Middle Aged
Natriuretic Peptide, Brain/analysis/*blood
Prognosis
Risk Factors
Stroke/*blood/physiopathology
Up-Regulation/physiology
LA - eng
N1 - Di Angelantonio, Emanuele
De Castro, Stefano
Toni, Danilo
Sacchetti, Maria Luisa
Biraschi, Francesco
Prencipe, Massimiliano
Fiorelli, Marco
Journal Article
Netherlands
J Neurol Sci. 2007 Sep 15;260(1-2):139-42. doi: 10.1016/j.jns.2007.04.018. Epub
2007 May 21.
PY - 2007
SN - 0022-510X (Print)
0022-510x
SP - 139-42
ST - Determinants of plasma levels of brain natriuretic peptide after acute
ischemic stroke or TIA
T2 - J Neurol Sci
TI - Determinants of plasma levels of brain natriuretic peptide after acute
ischemic stroke or TIA
VL - 260
ID - 2358
ER -
TY - JOUR
AB - Electrocardiographic abnormalities associated with intracranial diseases,
especially subarachnoid hemorrhage, are well known, while there is hardly mention
of cardiac arrhythmias in the neurological and cardiological literature. In order
to assess the incidence of arrhythmias 52 consecutive patients with subarachnoid
hemorrhage secondary to ruptured aneurysm were investigated with 24-hour Holter
recordings. Bradyarrhythmias and tachyarrhythmias were found in 46 patients (88%);
premature ventricular beats in 25 pts (12 of these in 3rd-5th Lown classes),
ventricular tachycardia in 2, premature supraventricular beats in 14, paroxysmal
atrial fibrillation in 1, sinoatrial blocks and arrests in 18, atrioventricular
dissociation in 2 and idioventricular rythm in 2. Moreover in 5 pts ST segment
changes were found, suggestive of transitory acute myocardial ischemia. The
presence and severity of arrhythmias were correlated with the time elapsed from the
episode of bleeding, with the QT interval, and with the hemorrhage extent. Our
results indicate an high incidence of arrhythmias in subarachnoid hemorrhage,
sometimes serious mainly in early stage. Continuous electrocardiographic monitoring
is therefore extremely useful and provides data for therapeutic consideration.
AN - 6468812
AU - Lusa, A. M.
AU - Manini, G. L.
AU - Dominici, P.
AU - Andreoli, A.
AU - Limoni, P.
AU - Pinelli, G.
DA - May
DP - NLM
ET - 1984/05/01
IS - 5
J2 - Giornale italiano di cardiologia
KW - Adult
Aged
Arrhythmias, Cardiac/*complications/diagnosis
Female
Humans
Male
Middle Aged
Prospective Studies
Subarachnoid Hemorrhage/*complications
LA - ita
N1 - Di Pasquale, G
Lusa, A M
Manini, G L
Dominici, P
Andreoli, A
Limoni, P
Pinelli, G
English Abstract
Journal Article
Italy
G Ital Cardiol. 1984 May;14(5):323-9.
OP - Aritmie cardiache associate ad emorragia subaracnoidea. Studio prospettico
con elettrocardiografia dinamica.
PY - 1984
SN - 0046-5968 (Print)
0046-5968
SP - 323-9
ST - [Cardiac arrhythmias associated with subarachnoid hemorrhage. Prospective
study with dynamic electrocardiography]
T2 - G Ital Cardiol
TI - [Cardiac arrhythmias associated with subarachnoid hemorrhage. Prospective
study with dynamic electrocardiography]
VL - 14
ID - 2811
ER -
TY - JOUR
AB - To determine the frequency and severity of cardiac arrhythmias in
intracranial subarachnoid hemorrhage, 120 nonselected patients were prospectively
studied by 24-hour Holter monitoring. Arrhythmias were found in 96 of 107 patients
(90%) with adequate Holter recording: ventricular premature complexes in 49,
nonsustained ventricular tachycardia in 5, supraventricular premature complexes in
29, paroxysmal supraventricular tachycardia or atrial fibrillation in 9, sinoatrial
block and arrest in 29, second-degree atrioventricular block in 1, atrioventricular
dissociation in 4 and idioventricular rhythm in 2. Life-threatening ventricular
arrhythmias (torsades de pointes-type ventricular tachycardia) occurred in 4
patients, degenerating into either ventricular flutter or fibrillation in 2. ST-
segment changes suggestive of acute transitory myocardial ischemia were found in 8
patients (1.5 mm or more of ST depression in 7 patients and 1.5 mm or more of ST
elevation in 1 patient). The frequency and severity of arrhythmias were
significantly higher in patients studied within 48 hours of subarachnoid
hemorrhage; serious ventricular arrhythmias were associated with QTc prolongation
more than 550 ms and with hypokalemia less than 3.5 mEq/liter. No correlation was
found between age, clinical condition, site and extent of subarachnoid hemorrhage
and either the occurrence or severity of arrhythmias. The results of our study
indicate an extremely high incidence of arrhythmias, sometimes serious, in
subarachnoid hemorrhage, especially in the first 48 hours after hemorrhage.
Continuous electrocardiographic monitoring is therefore mandatory.
AN - 3825900
AU - Pinelli, G.
AU - Andreoli, A.
AU - Manini, G.
AU - Grazi, P.
AU - Tognetti, F.
DA - Mar 1
DO - 10.1016/0002-9149(87)91176-3
DP - NLM
ET - 1987/03/01
IS - 6
KW - Adolescent
Adult
Aged
Arrhythmias, Cardiac/blood/*diagnosis/etiology
Female
Heart Ventricles
Humans
Male
Middle Aged
Potassium/blood
Prospective Studies
Subarachnoid Hemorrhage/blood/*complications
Time Factors
LA - eng
N1 - Di Pasquale, G
Pinelli, G
Andreoli, A
Manini, G
Grazi, P
Tognetti, F
Journal Article
United States
Am J Cardiol. 1987 Mar 1;59(6):596-600. doi: 10.1016/0002-9149(87)91176-3.
PY - 1987
SN - 0002-9149 (Print)
0002-9149
SP - 596-600
ST - Holter detection of cardiac arrhythmias in intracranial subarachnoid
hemorrhage
T2 - Am J Cardiol
TI - Holter detection of cardiac arrhythmias in intracranial subarachnoid
hemorrhage
VL - 59
ID - 2805
ER -
TY - JOUR
AB - OBJECTIVE: To determine factors related to mortality within hospital after
successful resuscitation from ventricular fibrillation outside hospital by a mobile
coronary care unit manned by a physician. DESIGN: Retrospective review of records
of patients resuscitated and admitted to hospital between 1 January 1966 and 31
December 1987. SETTING: Mobile coronary care unit, coronary care unit, and
cardiology department. PATIENTS: 281 patients (227 male), aged 14-82 (mean 58)
successfully resuscitated from ventricular fibrillation outside hospital of whom
182 (65%) developed ventricular fibrillation before the arrival of the mobile
coronary care unit. The aetiology of ventricular fibrillation was acute myocardial
infarction in 194 patients (69%), ischaemic heart disease without infarction in 71
(25%), and other or unknown in 16 (6%). MAIN OUTCOME MEASURES: Death within
hospital. RESULTS: There were 91 deaths in hospital (32%). Factors on univariate
analysis significantly associated with increased mortality were patient age > or =
60 years, previous myocardial infarction or cerebrovascular disease, prior digoxin
or diuretic treatment, collapse without prior chest pain or with pain lasting 30
minutes or less, defibrillation delayed by > or = 5 min, > or = four shocks
required to correct ventricular fibrillation, left ventricular failure or pulmonary
oedema and cardiogenic shock after successful defibrillation, and coma on admission
to hospital. On multivariate analysis the most important factors (in rank order)
were cardiogenic shock after defibrillation, coma on admission to hospital, age >
or = 60 years and the requirement for four or more shocks to correct ventricular
fibrillation. CONCLUSIONS: The in-hospital mortality of patients resuscitated from
ventricular fibrillation outside hospital was related to patient characteristics
before the cardiac arrest and to the immediate haemodynamic and neurological status
after correction of ventricular fibrillation as well as to factors at the
resuscitation itself. The in-hospital mortality of this study compares favourably
with the results obtained by units staffed by paramedical workers and emergency
medical technicians, although 35% (99/281) of the patients had ventricular
fibrillation after the arrival of the mobile unit and defibrillation was thus
rapid.
AD - Regional Medical Cardiology Centre, Royal Victoria Hospital, Belfast,
Northern Ireland.
AN - 1389711
AU - Dickey, W.
AU - Adgey, A. A.
C2 - PMC1024846
DA - Apr
DO - 10.1136/hrt.67.4.334
DP - NLM
ET - 1992/04/01
IS - 4
KW - Adult
Age Factors
Aged
Aged, 80 and over
*Ambulatory Care
Female
*Hospital Mortality
Humans
Male
Middle Aged
Northern Ireland/epidemiology
*Resuscitation
Risk Factors
Ventricular Fibrillation/etiology/*mortality/therapy
LA - eng
N1 - Dickey, W
Adgey, A A
Journal Article
Br Heart J. 1992 Apr;67(4):334-8. doi: 10.1136/hrt.67.4.334.
PY - 1992
SN - 0007-0769 (Print)
0007-0769
SP - 334-8
ST - Mortality within hospital after resuscitation from ventricular fibrillation
outside hospital
T2 - Br Heart J
TI - Mortality within hospital after resuscitation from ventricular fibrillation
outside hospital
VL - 67
ID - 2878
ER -
TY - JOUR
AB - In 100 consecutive patients with acute cerebrovascular accident, due to
cerebral thrombosis in 72, cerebral hemorrhage in 12, embolus in 6, and
subarachnoid hemorrhage in 10, there were 90 who had electrocardiographic
abnormalities during the first three days after admission, compared to 50% in a
control group. The patients with cerebrovascular accident had a 7- to 10-fold
higher incidence of ST segment depression, prolonged Q-Tc interval and atrial
fibrillation, and a 2- to 4-fold higher incidence of T wave inversion, conduction
defects, premature ventricular beats and left ventricular hypetrophy. Patients who
died had a 2-, 3- and 5-fold higher incidence of electrocardiographic evidence of
recent myocardial infarction, atrial fibrillation and conduction defects than those
who survived, but these changes occurred in only 5, 21 and 14% of all patients, and
other electrocardiographic changes could not be correlated with mortality. During
the first three days after admission 29 patients had elevation of serum enzymes
which may be derived from cardiac muscle, particularly CPK, which was increased 6-
fold, compared to 2-fold increases in HBDH, GOT, and LDH. Only 5 of these patients
had electrocardiographic evidence of recent myocardial infarction. Patients with
elevated serum CPK had a 2-fold higher incidence of ST segment depression, T wave
inversion, conduction defects and atrial fibrillation than those with normal CPK,
and a mortality of 66%, compared to 30%. Of 41 patients who died, 49% had elevated
serum CPK, compared to 15% of 59 patients who survived. These differences were
significant (P less than 0.01). Serum CPK was more frequently helpful than the
electrocardiogram in evaluating the extent of cardiac damage and in predicting
mortality. Patients with acute cerebrovascular accident should have repeated
evaluation of serum CPK and the ECG, and be monitored for arrhythmias.
AN - 898240
AU - Dimant, J.
AU - Grob, D.
DA - Jul-Aug
DO - 10.1161/01.str.8.4.448
DP - NLM
ET - 1977/07/01
IS - 4
J2 - Stroke
KW - Adult
Aged
Arrhythmias, Cardiac/diagnosis/*etiology
Cerebrovascular Disorders/*complications/mortality
Creatine Kinase/blood
Electrocardiography
Female
Humans
Male
Myocardial Infarction/diagnosis/*etiology
LA - eng
N1 - Dimant, J
Grob, D
Journal Article
United States
Stroke. 1977 Jul-Aug;8(4):448-55. doi: 10.1161/01.str.8.4.448.
PY - 1977
SN - 0039-2499 (Print)
0039-2499
SP - 448-55
ST - Electrocardiographic changes and myocardial damage in patients with acute
cerebrovascular accidents
T2 - Stroke
TI - Electrocardiographic changes and myocardial damage in patients with acute
cerebrovascular accidents
VL - 8
ID - 2798
ER -
TY - JOUR
AB - PURPOSE: Ischemic stroke is a frequent pathology with high rate of recurrence
and significant morbidity and mortality. There are several causes of stroke,
affecting prognosis, outcomes, and management, but in many cases, the etiology
remains undetermined. We hypothesized that atrial fibrillation was involved in this
pathology but underdiagnosed by standard methods. The aim of the study was to
determine the incidence of atrial fibrillation in cryptogenic ischemic stroke by
using continuous monitoring of the heart rate over several months. The secondary
objective was to test the value of atrial vulnerability assessment in predicting
spontaneous atrial fibrillation. METHODS AND RESULTS: We prospectively enrolled 24
patients under 75 years of age, 15 men and 9 women of mean age 49 years, who within
the last 4 months had experienced cryptogenic stroke diagnosed by clinical
presentation and brain imaging and presumed to be of cardioembolic mechanism. All
causes of stroke were excluded by normal 12-lead ECG, 24-h Holter monitoring,
echocardiography, cervical Doppler, hematological, and inflammatory tests. All
patients underwent electrophysiological study. Of the patients, 37.5% had latent
atrial vulnerability, and 33.3% had inducible sustained arrhythmia. Patients were
secondarily implanted with an implantable loop recorder to look for spontaneous
atrial fibrillation over a mean follow-up interval of 14.5 months. No sustained
arrhythmia was found. Only one patient had non-significant episodes of atrial
fibrillation. CONCLUSION: In this study, symptomatic atrial fibrillation or AF with
fast ventricular rate has not been demonstrated by the implantable loop recorder in
patients under 75 years with unexplained cerebral ischemia. The use of this device
should not be generalized in the systematic evaluation of these patients. In
addition, this study attests that the assessment of atrial vulnerability is poor at
predicting spontaneous arrhythmia in such patients.
AD - Service de Cardiologie B, pôle Coeur, Thorax, Vaisseaux, hôpital Trousseau,
Tours University, CHRU de Tours, 37044, Tours Cedex 9, France.
AN - 20454840
AU - Dion, F.
AU - Saudeau, D.
AU - Bonnaud, I.
AU - Friocourt, P.
AU - Bonneau, A.
AU - Poret, P.
AU - Giraudeau, B.
AU - Régina, S.
AU - Fauchier, L.
AU - Babuty, D.
C2 - PMC2921065
DA - Aug
DO - 10.1007/s10840-010-9485-5
DP - NLM
ET - 2010/05/11
IS - 2
J2 - Journal of interventional cardiac electrophysiology : an international
journal of arrhythmias and pacing
KW - Adolescent
Adult
Aged
Atrial Fibrillation/*complications/*epidemiology
Biomarkers/blood
Brain Ischemia/*epidemiology/*etiology
Echocardiography
Female
Humans
Incidence
Male
Middle Aged
Prevalence
Ultrasonography, Doppler
LA - eng
N1 - 1572-8595
Dion, Fanny
Saudeau, Denis
Bonnaud, Isabelle
Friocourt, Patrick
Bonneau, Armel
Poret, Philippe
Giraudeau, Bruno
Régina, Sandra
Fauchier, Laurent
Babuty, Dominique
Journal Article
Multicenter Study
J Interv Card Electrophysiol. 2010 Aug;28(2):101-7. doi: 10.1007/s10840-010-9485-5.
Epub 2010 May 8.
PY - 2010
SN - 1383-875X (Print)
1383-875x
SP - 101-7
ST - Unexpected low prevalence of atrial fibrillation in cryptogenic ischemic
stroke: a prospective study
T2 - J Interv Card Electrophysiol
TI - Unexpected low prevalence of atrial fibrillation in cryptogenic ischemic
stroke: a prospective study
VL - 28
ID - 2837
ER -
TY - JOUR
AB - BACKGROUND: Atrial fibrillation (AF) is a common arrhythmia that frequently
recurs after restoration of sinus rhythm. In a consistent percentage of cases, AF
recurrences are asymptomatic, thus making its clinical management difficult in
relation to both therapeutic efficacy and thromboembolic risk. METHODS: The GISSI-
AF trial enrolled 1,442 patients in sinus rhythm with previous AF episodes.
Patients were randomized to valsartan or placebo and followed for 12 months. To
improve the likelihood of detecting arrhythmic recurrences, arrhythmic follow-up
was based on both programmed or symptom-related control visits and transtelephonic
electrocardiographic transmissions. The present post hoc analysis was performed on
1,638 arrhythmic episodes that occurred in 623 patients. RESULTS: Asymptomatic AF
recurrences were present in 49.5% of patients. In multivariable analysis,
asymptomatic AF recurrences were significantly associated with a longer duration of
qualifying arrhythmias (odds ratio [95% CI] 1.57 (1.26-1.97), P < .0001). A lower
ventricular response (P < .001) and a longer duration of the arrhythmic recurrence
(P < .001) characterized asymptomatic episodes. Patients with asymptomatic events
were more likely to be in AF at the time of electrocardiographic control at the end
of the 12-month follow-up (adjusted odds ratio [95% CI] 4.9 (2.8-8.4), P < .001).
Moreover, a higher CHADS(2) (Congestive heart failure, history of Hypertension,
Age≥75 years, Diabetes mellitus, and past history of Stroke or TIA doubled) score
and a more frequent use of amiodarone, calcium-channel blockers, and digitalis
characterized patients with asymptomatic, whereas 1C drugs were more often used in
subjects with symptomatic recurrences. CONCLUSION: Asymptomatic AF recurrences were
frequent in the GISSI-AF study population in patients who were more likely to
develop persistent-permanent AF and were characterized by an increased
thromboembolic risk.
AD - Department of Cardiology, Santa Chiara Hospital, Trento, Italy.
gissiaf@anmco.it
AN - 21835301
AU - Disertori, M.
AU - Lombardi, F.
AU - Barlera, S.
AU - Maggioni, A. P.
AU - Favero, C.
AU - Franzosi, M. G.
AU - Lucci, D.
AU - Staszewsky, L.
AU - Fabbri, G.
AU - Quintarelli, S.
AU - Bianconi, L.
AU - Latini, R.
DA - Aug
DO - 10.1016/j.ahj.2011.05.008
DP - NLM
ET - 2011/08/13
IS - 2
KW - Aged
Angiotensin II Type 1 Receptor Blockers/*administration & dosage
Atrial Fibrillation/*drug therapy/epidemiology/physiopathology
Double-Blind Method
Electrocardiography
Female
Follow-Up Studies
Heart Rate/*drug effects
Humans
Incidence
Italy/epidemiology
Male
Prognosis
Prospective Studies
Recurrence
Tetrazoles/*administration & dosage
Valine/administration & dosage/*analogs & derivatives
Valsartan
LA - eng
N1 - 1097-6744
Disertori, Marcello
Lombardi, Federico
Barlera, Simona
Maggioni, Aldo Pietro
Favero, Chiara
Franzosi, Maria Grazia
Lucci, Donata
Staszewsky, Lidia
Fabbri, Gianna
Quintarelli, Silvia
Bianconi, Leopoldo
Latini, Roberto
Comparative Study
Journal Article
Multicenter Study
United States
Am Heart J. 2011 Aug;162(2):382-9. doi: 10.1016/j.ahj.2011.05.008. Epub 2011 Jul 7.
PY - 2011
SN - 0002-8703
SP - 382-9
ST - Clinical characteristics of patients with asymptomatic recurrences of atrial
fibrillation in the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto
Miocardico-Atrial Fibrillation (GISSI-AF) trial
T2 - Am Heart J
TI - Clinical characteristics of patients with asymptomatic recurrences of atrial
fibrillation in the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto
Miocardico-Atrial Fibrillation (GISSI-AF) trial
VL - 162
ID - 2886
ER -
TY - JOUR
AB - A 66-year-old woman with a history of tissue aortic valve replacement and
chronic back pain presented to the emergency department with a suspected right leg
deep vein thrombosis. A recent outpatient MRI had revealed discitis. A ventricular
fibrillation cardiac arrest occurred in the emergency department. Cardiac output
was restored on the fifth defibrillation. A transthoracic echocardiogram showed
large aortic valve vegetations. Clinical impression was of infective endocarditis
with cardiac arrest secondary to coronary artery embolisation. Peripheral blood
cultures grew Cardiobacterium hominis, and appropriate intravenous antibiotic
therapy was administered. The infected prosthetic valve was excised. The patient
experienced postoperative complete heart block and a right hemisphere
cerebrovascular accident, however she is now recovering well. This case describes
an unusual case of infective endocarditis secondary to C. hominis, with disc, leg,
coronary artery and brain septic embolisation. Infective endocarditis is an
important differential diagnosis in multisystem presentations.
AD - Hammersmith Hospital, London, UK.
AN - 24859548
AU - Donovan, J.
AU - Hatcher, J.
AU - Riddell, A.
AU - Tiberi, S.
C2 - PMC4039873
DA - May 23
DO - 10.1136/bcr-2013-202215
DP - NLM
ET - 2014/05/27
J2 - BMJ case reports
KW - Aged
*Aortic Valve
Back Pain/etiology
Cardiobacterium/*isolation & purification
Coronary Occlusion/*etiology
Discitis/*etiology
Embolism/etiology
Endocarditis, Bacterial/*complications
Female
Gram-Negative Bacterial Infections
Heart Arrest/*etiology
Heart Valve Prosthesis/*adverse effects
Humans
Intervertebral Disc/blood supply
Intracranial Embolism/*etiology
Leg/blood supply
Prosthesis-Related Infections/*complications
LA - eng
N1 - 1757-790x
Donovan, Joseph
Hatcher, James
Riddell, Anna
Tiberi, Simon
Case Reports
Journal Article
BMJ Case Rep. 2014 May 23;2014:bcr2013202215. doi: 10.1136/bcr-2013-202215.
PY - 2014
SN - 1757-790x
ST - Back pain, leg swelling and a cardiac arrest: an interesting case of
endocarditis
T2 - BMJ Case Rep
TI - Back pain, leg swelling and a cardiac arrest: an interesting case of
endocarditis
VL - 2014
ID - 3045
ER -
TY - JOUR
AB - Implantation of automatic internal cardiac defibrillators (AICD) for
management of arrhythmias necessitates the induction of ventricular fibrillation
(VF) to test the device adequately. The profound hypotension associated with
induced arrhythmia and subsequent circulatory arrest may result in cerebral
ischemia. To characterize cerebral ischemia, we used a five-lead Lifescan brain
activity monitor to examine changes in cerebral activity in 10 patients having AICD
placement. The duration of hypotension, as defined by a mean arterial pressure
(MAP) < 50 mm Hg, was recorded, and the corresponding changes in brain activity
were evaluated during 51 episodes of circulatory arrest. The number of episodes for
each patient ranged from 2 to 14. The average duration of hypotension per episode
was 26.2 seconds, with a range of 8 to 67 seconds. Brain activity changes
characteristic of cerebral ischemia occurred in 46 of the 51 events (90%). Cerebral
ischemia did not occur when the duration of hypotension was less than 16 seconds (5
episodes). The duration of cerebral ischemia ranged from 50 to 279 seconds (average
84.9 seconds) and did not correlate with the duration of hypotension or the order
of the episodes in the testing sequence. These findings suggest that reevaluation
of standard monitoring practice for AICD implantation may be warranted.
AD - Department of Anesthesiology, Medical University of South Carolina,
Charleston 29425.
AN - 8488400
AU - Dorman, B. H.
AU - Conroy, J. M.
AU - Baker, J. D., 3rd
AU - Kratz, J. M.
AU - Leman, R. B.
DA - May
DO - 10.1097/00007611-199305000-00009
DP - NLM
ET - 1993/05/01
IS - 5
J2 - Southern medical journal
KW - Brain Ischemia/diagnosis/etiology
*Electroencephalography
Female
Humans
Intraoperative Complications/diagnosis
Male
Middle Aged
*Monitoring, Intraoperative
Ventricular Fibrillation/etiology/physiopathology
LA - eng
N1 - Dorman, B H
Conroy, J M
Baker, J D 3rd
Kratz, J M
Leman, R B
Journal Article
United States
South Med J. 1993 May;86(5):533-6. doi: 10.1097/00007611-199305000-00009.
PY - 1993
SN - 0038-4348 (Print)
0038-4348
SP - 533-6
ST - Cerebral monitoring during implantation of automatic internal cardiac
defibrillators
T2 - South Med J
TI - Cerebral monitoring during implantation of automatic internal cardiac
defibrillators
VL - 86
ID - 2613
ER -
TY - JOUR
AB - The extension of the Q-T interval of ECG can be accompanied by loss of
consciousness and even sudden death. A unified approach is required to assess the
normal duration of the Q-T interval. A table of maximum normal limits of the Q-T
interval is given calculated with Bazett's formula with the coefficient K equal to
0.42. It is suggested to subdivide the extensions of the Q-T intervals according to
the clinical manifestations with attacks of loss of consciousness and without them
and also according to aetiology: congenital syndrome Jarvel-Lange-Nielsen and that
of Romano-Ward, the acquired acute (intoxications, disorders of electrolyte
balance, lesions of the central nervous system, myocardial infarction, myocarditis,
medicinal reactions) and the acquired chronic (diffuse lesions of the myocardium,
of the brain etc.). Personal observations of syndromes of extended Q-T intervals of
different aetiology are given with attacks of ventricular tachycardia of the
"torsade de pointes" type and ventricular fibrillation.
AN - 7300093
AU - Doshchitsin, V. L.
AU - Sigan, E. S.
AU - Sedov, V. V.
DA - Oct
DP - NLM
ET - 1981/10/01
IS - 10
J2 - Kardiologiia
KW - Arrhythmias, Cardiac/classification/*physiopathology
Female
Heart Rate
Humans
Male
Middle Aged
Syncope/diagnosis/physiopathology
Syndrome
Ventricular Fibrillation/diagnosis/physiopathology
LA - rus
N1 - Doshchitsin, V L
Sigan, E S
Sedov, V V
Case Reports
English Abstract
Journal Article
Russia (Federation)
Kardiologiia. 1981 Oct;21(10):22-8.
OP - Udlinenie intervala Q-T: classification, klinicheskoe znachenie.
PY - 1981
SN - 0022-9040 (Print)
0022-9040
SP - 22-8
ST - [Prolongation of the Q-T interval of the ECG: classification and clinical
significance]
T2 - Kardiologiia
TI - [Prolongation of the Q-T interval of the ECG: classification and clinical
significance]
VL - 21
ID - 2753
ER -
TY - JOUR
AB - Ventricular outpouchings include acquired abnormalities (aneurysms and
pseudoaneurysms) and congenital ventricular diverticula (CVD). CVD represent rare
cardiac pathologies. Although CVD is often associated with other cardiac and
extracardiac congenital anomalies, it can also be incidentally observed in
otherwise healthy subjects. CVD may lead to significant morbidity and even have
lethal consequences. We describe a case of arrhythmogenic left ventricle (LV)
apical CVD revealed by cardiac magnetic resonance imaging (CMRI) after being
initially overlooked by echocardiography. The paper includes the review of the
literature also. This clinical case highlights the possible association of this
pathology with recurrent ventricular tachycardia and stroke, and illustrates the
importance of multimodal imaging approach in differential diagnosis.
AD - 2nd Department of Medicine - Department of Cardiovascular Medicine, First
Faculty of Medicine, Charles University in Prague and General University Hospital
in Prague. Electronic address: gabriela.dostalova@vfn.cz.
2nd Department of Medicine - Department of Cardiovascular Medicine, First Faculty
of Medicine, Charles University in Prague and General University Hospital in
Prague.
Department of Radiology, First Faculty of Medicine, Charles University in Prague
and General University Hospital in Prague.
Department of Pathology, First Faculty of Medicine, Charles University in Prague
and General University Hospital in Prague.
2nd Department of Surgery, Cardiovascular Surgery, First Faculty of Medicine,
Charles University in Prague and General University Hospital in Prague.
AN - 28219755
AU - Dostálová, G.
AU - Paleček, T.
AU - Kuchynka, P.
AU - Havránek, Š
AU - Mašek, M.
AU - Hlubocká, Z.
AU - Karetová, D.
AU - Wichterle, D.
AU - Dušková, J.
AU - Lindner, J.
AU - Linhart, A.
DA - May-Jun
DO - 10.1016/j.carpath.2017.01.009
DP - NLM
ET - 2017/02/22
J2 - Cardiovascular pathology : the official journal of the Society for
Cardiovascular Pathology
KW - Diverticulum/*congenital/diagnostic imaging/physiopathology/surgery
Echocardiography, Doppler, Pulsed
Fibrosis
Heart Defects, Congenital/*complications/diagnostic imaging/physiopathology/surgery
Heart Ventricles/*abnormalities/diagnostic imaging/physiopathology/surgery
Humans
Recurrence
Tachycardia, Ventricular/diagnosis/*etiology/physiopathology
Treatment Outcome
Congenital heart disease
Diverticulum
Left ventricle
Ventricular tachycardia
LA - eng
N1 - 1879-1336
Dostálová, Gabriela
Paleček, Tomáš
Kuchynka, Petr
Havránek, Štěpán
Mašek, Martin
Hlubocká, Zuzana
Karetová, Debora
Wichterle, Dan
Dušková, Jaroslava
Lindner, Jaroslav
Linhart, Aleš
Case Reports
Journal Article
Review
United States
Cardiovasc Pathol. 2017 May-Jun;28:3-6. doi: 10.1016/j.carpath.2017.01.009. Epub
2017 Feb 4.
PY - 2017
SN - 1054-8807
SP - 3-6
ST - A congenital diverticulum of the left ventricular apex manifested by stroke
and recurrent ventricular tachycardia
T2 - Cardiovasc Pathol
TI - A congenital diverticulum of the left ventricular apex manifested by stroke
and recurrent ventricular tachycardia
VL - 28
ID - 2359
ER -
TY - JOUR
AB - OBJECTIVES: To determine if there is an increased risk of admission to
hospital for various diseases among vinyl chloride monomer (VCM) workers. METHODS:
2224 workers with occupational exposure to VCM were identified for occurrence of
disease based on a search of hospital computer files on labour insurance. These
data were compared with those of workers manufacturing optical equipment and
motorcycles from 1 January 1985 to 31 March 1994. Cardiovascular and
cerebrovascular diseases were used as reference diseases, and the age adjusted
morbidity odds ratio (MOR) was calculated. RESULTS: A significantly increased risk
of admission to hospital among VCM workers due to primary liver cancer (MOR 4.5-
6.5), cirrhosis of the liver (MOR 1.7-2.1), and other chronic diseases (MOR 1.5-
2.0) was found. There were eight cases of primary liver cancer, all with heavy
previous exposure to VCM. Another four cases of hepatoma in polyvinyl chloride
(PVC) workers were found in the death registry. Ten out of 11 cases of hepatoma,
with detailed medical information, were carriers of hepatitis B virus. The average
latent period (20 years) was not different from other studies. Alternative agents
of primary liver cancer were largely ruled out, suggesting that the combination of
hepatitis B and VCM may lead to primary liver cancer. CONCLUSION: There is an
increased risk of primary liver cancer in workers exposed to VCM, although the
incomplete coverage of the Labor Insurance Bureau data warrants cautious
interpretation of the results. Further study exploring the synergistic effects of
VCM and hepatitis B is also indicated.
AD - Institute of Occupational Safety and Health, Council of Labor Affairs,
Taipei, Taiwan.
AN - 9849539
AU - Du, C. L.
AU - Wang, J. D.
C2 - PMC1757621
DA - Aug
DO - 10.1136/oem.55.8.528
DP - NLM
ET - 1998/12/16
IS - 8
J2 - Occupational and environmental medicine
KW - Adult
Age Factors
Aged
*Chemical Industry
Chronic Disease
Female
Humans
Liver Cirrhosis/*chemically induced/epidemiology
Liver Neoplasms/*chemically induced/epidemiology
Male
Middle Aged
Morbidity
Occupational Diseases/*chemically induced/epidemiology
Taiwan/epidemiology
Vinyl Chloride/*adverse effects
LA - eng
N1 - 1470-7926
Du, C L
Wang, J D
Journal Article
Occup Environ Med. 1998 Aug;55(8):528-32. doi: 10.1136/oem.55.8.528.
PY - 1998
SN - 1351-0711 (Print)
1351-0711
SP - 528-32
ST - Increased morbidity odds ratio of primary liver cancer and cirrhosis of the
liver among vinyl chloride monomer workers
T2 - Occup Environ Med
TI - Increased morbidity odds ratio of primary liver cancer and cirrhosis of the
liver among vinyl chloride monomer workers
VL - 55
ID - 3126
ER -
TY - JOUR
AB - BACKGROUND: In patients with atrial fibrillation, left atrial appendage
closure with the Watchman device prevents thromboembolism from the left atrial
appendage; however, thrombus may form on the left atrial face of the device, and
then potentially embolize. Herein, we studied the incidence, predictors, and
clinical outcome of device-related thrombus (DRT) using a large series of clinical
trial cohorts of patients undergoing Watchman implantation. METHODS: We studied the
device arms of 4 prospective Food and Drug Administration trials: PROTECT-AF
(Watchman Left Atrial Appendage System for Embolic Protection in Patients With
Atrial Fibrillation) (n=463); PREVAIL (Evaluation of the Watchman LAA Closure
Device in Patients With Atrial Fibrillation Versus Long Term Warfarin Therapy)
(n=269); CAP (Continued Access to PROTECT AF registry) (n=566); and CAP2 (Continued
Access to PREVAIL registry) (n=578). Surveillance transesophageal echocardiographs
were performed at 45 days and 12 months in all patients, and also at 6 months in
the randomized control trials. We assessed both the incidence of DRT during these
transesophageal echocardiographs (and other unscheduled transesophageal
echocardiographs), and clinical outcomes of postprocedure stroke or systemic
embolism (SSE) and adjusted for CHA(2)DS(2)-VASC and HAS-BLED scores. RESULTS: Of
1739 patients who received an implant (7159 patient-years follow-up; CHA(2)DS(2)-
VASc=4.0), DRT was seen in 65 patients (3.74%). The rates of SSE with and without
DRT were 7.46 and 1.78 per 100 patient-years (adjusted rate ratio, 3.55; 95%
confidence interval [CI], 2.18-5.79; P<0.001), and ischemic SSE rates were 6.28 and
1.65 per 100 patient-years (adjusted rate ratio, 3.22; 95% CI, 1.90-5.45, P<0.001).
On multivariable modeling analysis, the predictors of DRT were as follows: history
of transient ischemic attack or stroke (odds ratio [OR], 2.31; 95% CI, 1.26-4.25;
P=0.007), permanent atrial fibrillation (OR, 2.24; 95% CI, 1.19-4.20; P=0.012);
vascular disease (OR, 2.06; 95% CI, 1.08-3.91; P=0.028); left atrial appendage
diameter (OR, 1.06 per mm increase; 95% CI, 1.01-1.12; P=0.019); left ventricular
ejection fraction (OR, 0.96 per 1% increase; 95% CI, 0.94-0.99; P=0.009). DRT and
SSE both occurred in 17 of 65 patients (26.2%). Of the 19 SSE events in these
patients with DRT, 9 of 19 (47.4%) and 12 of 19 (63.2%) occurred within 1 and 6
months of DRT detection. Conversely, after left atrial appendage closure, most SSEs
(123/142, 86.62%) occurred in patients without DRT. CONCLUSIONS: After left atrial
appendage closure with Watchman, DRT (≈3.7%) is not frequent but, when present, is
associated with a higher rate of stroke and systemic embolism.
AD - Icahn School of Medicine at Mount Sinai, New York, NY (S.R.D., V.Y.R.).
Cedars Sinai Medical Center, Los Angeles, CA (S.K.).
Mayo Clinic, Rochester, MN (D.R.H.).
Pacific Heart Institute, Santa Monica, CA (S.K.D.).
Arizona Heart Rhythm Center, Phoenix (V.S.).
Scripps Clinic, La Jolla, CA (D.N.G.).
Delray Medical, Delray Beach, FL (B.M.).
Boston Scientific Corporation, St. Paul, MN (N.T.G.).
University of Missouri-Kansas City (M.L.M.).
AN - 29752398
AU - Dukkipati, S. R.
AU - Kar, S.
AU - Holmes, D. R.
AU - Doshi, S. K.
AU - Swarup, V.
AU - Gibson, D. N.
AU - Maini, B.
AU - Gordon, N. T.
AU - Main, M. L.
AU - Reddy, V. Y.
DA - Aug 28
DP - NLM
ET - 2018/05/13
IS - 9
J2 - Circulation
KW - Aged
Aged, 80 and over
Atrial Appendage/diagnostic imaging/*physiopathology
Atrial Fibrillation/diagnosis/epidemiology/physiopathology/*therapy
Cardiac Catheterization/*adverse effects/*instrumentation
Female
Humans
Incidence
Intracranial Embolism/diagnostic imaging/*epidemiology
Male
Prosthesis Design
Registries
Risk Assessment
Risk Factors
Stroke/diagnostic imaging/*epidemiology
Thrombosis/diagnostic imaging/*epidemiology
Time Factors
Treatment Outcome
*atrial appendage
*percutaneous coronary intervention
*stroke
*thrombosis
LA - eng
N1 - 1524-4539
Dukkipati, Srinivas R
Kar, Saibal
Holmes, David R
Doshi, Shephal K
Swarup, Vijendra
Gibson, Douglas N
Maini, Brijeshwar
Gordon, Nicole T
Main, Michael L
Reddy, Vivek Y
Journal Article
United States
Circulation. 2018 Aug 28;138(9):874-885. doi: 10.1161/CIRCULATIONAHA.118.035090.
PY - 2018
SN - 0009-7322
SP - 874-885
ST - Device-Related Thrombus After Left Atrial Appendage Closure: Incidence,
Predictors, and Outcomes
T2 - Circulation
TI - Device-Related Thrombus After Left Atrial Appendage Closure: Incidence,
Predictors, and Outcomes
VL - 138
ID - 2300
ER -
TY - JOUR
AB - Obstructive sleep apnea is an increasingly common disorder and it is a novel
cardiovascular disease risk factor. Repetitive apneas and hypopneas during sleep
are accompanied by hypoxia, increased sympathetic activity and frequent arousals.
Sleep apnea has clearly been demonstrated to be an independent risk factor for
development of hypertension and it has also been implicated in the pathogenesis of
atherosclerosis, congestive heart failure, pulmonary hypertension, cardiac
arrhythmias and stroke. Several studies showed that obstructive sleep apnea is
associated with an increased risk of cardiovascular morbidity and mortality.
However, a number of trials that assessed the effect of continuous positive airway
pressure treatment have shown a reduction in blood pressure, decrease in cardiac
arrhythmias, improvement in left ventricular function and reduction in incidence
and mortality of cardiovascular diseases. Despite the available effective therapy
the majority of individuals with obstructive sleep apnea and cardiovascular disease
remains underdiagnosed and untreated.
AD - Budapesti Szent Ferenc Kórház, Budapest.
AN - 17256631
AU - Dunai, A.
AU - Mucsi, I.
AU - Juhász, J.
AU - Novák, M.
DA - Dec 3
DP - NLM
ET - 2007/01/30
IS - 48
J2 - Orvosi hetilap
KW - Arrhythmias, Cardiac/epidemiology/etiology
Blood Pressure
Cardiovascular Diseases/*epidemiology/*etiology/mortality/physiopathology
Heart Failure/epidemiology/etiology
Humans
Hypertension, Pulmonary/epidemiology/etiology
Myocardial Ischemia/epidemiology/etiology
Polysomnography
Positive-Pressure Respiration
Prognosis
Risk Factors
Sleep Apnea, Obstructive/*complications/physiopathology
Ventricular Function, Right
LA - hun
N1 - Dunai, Andrea
Mucsi, István
Juhász, János
Novák, Márta
English Abstract
Journal Article
Review
Hungary
Orv Hetil. 2006 Dec 3;147(48):2303-11.
OP - Az obstruktív alvási apnoe hatása a cardiovascularis betegségek kialakulására
es prognózisára.
PY - 2006
SN - 0030-6002 (Print)
0030-6002
SP - 2303-11
ST - [Obstructive sleep apnea and cardiovascular disease]
T2 - Orv Hetil
TI - [Obstructive sleep apnea and cardiovascular disease]
VL - 147
ID - 2432
ER -
TY - JOUR
AB - A 34-year-old man with severe aortic incompetence caused by Streptococcus
viridans developed severe central chest pain followed by complete heart block,
multifocal ventricular extrasystoles, lengthening of the QTc and signs of cerebral
emboli and pulmonary oedema. Early antibiotic therapy along with pacing, non-
invasive investigations coupled with early surgery contributed significantly to the
patient's survival.
AN - 6693217
AU - Dunn, H. M.
AU - McComb, J. M.
AU - Adgey, A. A.
DA - Jan
DO - 10.1016/0167-5273(84)90066-4
DP - NLM
ET - 1984/01/01
IS - 1
KW - Adult
*Aortic Valve/microbiology/surgery
Electrocardiography
Endocarditis, Bacterial/*complications
Heart Block/*etiology
Humans
Male
Streptococcal Infections/*complications
LA - eng
N1 - Dunn, H M
McComb, J M
Adgey, A A
Case Reports
Journal Article
Netherlands
Int J Cardiol. 1984 Jan;5(1):98-101. doi: 10.1016/0167-5273(84)90066-4.
PY - 1984
SN - 0167-5273 (Print)
0167-5273
SP - 98-101
ST - Aortic valve endocarditis complicated by complete heart block
T2 - Int J Cardiol
TI - Aortic valve endocarditis complicated by complete heart block
VL - 5
ID - 2964
ER -
TY - JOUR
AB - OBJECTIVE: Repeated induction of ventricular fibrillation with ensuing
alterations in electroencephalogram and jugular venous oxygen saturation is common
practice during insertion of transvenous implantable cardioverters/defibrillators.
We investigated whether these functional changes are also associated with cerebral
injury. DESIGN: Prospective study. SETTING: University hospital. PATIENTS: We
studied 45 patients undergoing implantable cardioverter/defibrillator insertion.
Eleven patients with cardiac pacemaker implantation, which was performed in the
same manner yet without the necessity to induce ventricular fibrillation, served as
controls. MEASUREMENTS AND MAIN RESULTS: Serum neuron-specific enolase and S100
were determined before, immediately postoperatively, and 2 hrs postoperatively. In
a randomly composed subgroup, neuron-specific enolase was also determined 6 and 24
hrs after surgery. Implantable cardioverter/defibrillator patients only showed an
increase of both markers postoperatively. Median neuron-specific enolase values
climbed from a preoperative 9.9 to 12.3 and 14.4 microg/L at 2 and 24 hrs after
surgery, respectively. This increase was associated with the number of shocks and
the cumulative time in circulatory arrest. The highest median S100 level (0.075
microg/L) was reached 2 hrs after the procedure. Neuron-specific enolase and S100
were extremely elevated (13.7 and 0.970 microg/L, respectively) in one patient
after an extended episode of ventricular fibrillation. Plasma hemoglobin levels
were in the normal range in implantable cardioverter/defibrillator patients
throughout the observation period. CONCLUSIONS: Apparently, even brief successive
periods of global cerebral ischemia cause neuronal damage without obvious severe
neurologic deficits. However, they may be related to subtle postoperative
neurologic or cognitive dysfunctions that a number of implantable
cardioverter/defibrillator patients exhibit after implantation.
AD - Division of Cardiothoracic Anesthesia and Intensive Care, University
Hospital, Vienna, Austria. matin.dworschak@univie.ac.at
AN - 12973163
AU - Dworschak, M.
AU - Franz, M.
AU - Czerny, M.
AU - Gorlitzer, M.
AU - Blaschek, M.
AU - Grubhofer, G.
AU - Haider, W.
DA - Aug
DO - 10.1097/01.Ccm.0000079610.88771.62
DP - NLM
ET - 2003/09/16
IS - 8
J2 - Critical care medicine
KW - Aged
Brain Ischemia/blood/*etiology
Female
Heart Arrest, Induced/*adverse effects
Humans
Male
Monitoring, Intraoperative
Phosphopyruvate Hydratase/*blood
Postoperative Period
Prospective Studies
S100 Proteins/*blood
LA - eng
N1 - Dworschak, Martin
Franz, Maximilian
Czerny, Martin
Gorlitzer, Michael
Blaschek, Marieluise
Grubhofer, Georg
Haider, Wolfram
Journal Article
United States
Crit Care Med. 2003 Aug;31(8):2085-9. doi: 10.1097/01.CCM.0000079610.88771.62.
PY - 2003
SN - 0090-3493 (Print)
0090-3493
SP - 2085-9
ST - Release of neuron-specific enolase and S100 after implantation of
cardioverters/defibrillators
T2 - Crit Care Med
TI - Release of neuron-specific enolase and S100 after implantation of
cardioverters/defibrillators
VL - 31
ID - 3026
ER -
TY - JOUR
AB - BACKGROUND: Comparative effectiveness reviews offer a systematic method to
critically appraise existing research and to identify unaddressed clinical areas in
cardiovascular disease where significant morbidity, mortality, and variation in the
use of resources persist. To delineate and help select areas where comparative
effectiveness reviews are needed, the Effective Health Care Program of the Agency
for Healthcare Research and Quality involved stakeholders in prioritization of the
research agenda. METHODS AND RESULTS: We involved a diverse panel of stakeholders
representing a broad range of clinical, policy, and patient perspectives. To assist
in prioritization of topics for evidence synthesis, we created a framework
evaluating 12 cardiovascular disease subcategories that reflect American College of
Cardiology/American Heart Association disease-based guidelines. We performed an
environmental scan for each disease subcategory to populate this framework with
existing knowledge, levels of evidence, and degrees of public interest. Through a
formalized process, 4 disease subcategories were prioritized: chronic coronary
artery disease, ventricular arrhythmias, heart failure, and cerebrovascular
disease. Within these subcategories, 11 topics that address the comparative safety
and effectiveness of existing treatments and evaluate emerging treatments were
nominated by the stakeholder panel to proceed for feasibility assessment before
developing comparative effectiveness reviews. CONCLUSIONS: Using a systematic
process deriving consensus from multiple stakeholders across cardiovascular disease
states, we generated a prioritized list of evidence synthesis topics to inform
decision makers. The topics vetted through this process seek to determine the
comparative safety and effectiveness of a range of treatments, both established and
emerging, and are immediately relevant for prevalent disease states.
AD - Duke Evidence-based Practice Center and Department of Medicine, Duke Clinical
Research Institute, Duke University, Durham, NC.
AN - 23481525
AU - Eapen, Z. J.
AU - McBroom, A. J.
AU - Gray, R.
AU - Musty, M. D.
AU - Hadley, C.
AU - Hernandez, A. F.
AU - Sanders, G. D.
DA - Mar 1
DO - 10.1161/circoutcomes.111.000046
DP - NLM
ET - 2013/03/14
IS - 2
J2 - Circulation. Cardiovascular quality and outcomes
KW - Arrhythmias, Cardiac/therapy
Cardiovascular Diseases/diagnosis/epidemiology/*therapy
Cerebrovascular Disorders/therapy
Chronic Disease
*Comparative Effectiveness Research
Consensus
Cooperative Behavior
Coronary Artery Disease/therapy
Evidence-Based Medicine
Health Care Rationing
Health Priorities
Heart Failure/therapy
Humans
Interdisciplinary Communication
Needs Assessment
*Outcome and Process Assessment, Health Care
Prevalence
Treatment Outcome
LA - eng
N1 - 1941-7705
Eapen, Zubin J
McBroom, Amanda J
Gray, Rebecca
Musty, Michael D
Hadley, Corey
Hernandez, Adrian F
Sanders, Gillian D
Journal Article
United States
Circ Cardiovasc Qual Outcomes. 2013 Mar 1;6(2):139-47. doi:
10.1161/CIRCOUTCOMES.111.000046. Epub 2013 Mar 12.
PY - 2013
SN - 1941-7713
SP - 139-47
ST - Priorities for comparative effectiveness reviews in cardiovascular disease
T2 - Circ Cardiovasc Qual Outcomes
TI - Priorities for comparative effectiveness reviews in cardiovascular disease
VL - 6
ID - 2991
ER -
TY - JOUR
AB - Background Preclinical data have indicated a link between use of vitamin K
antagonists ( VKA ) and detrimental effects on vascular structure and function. The
objective of the present study was to determine the relationship between VKA intake
and different phenotypes of subclinical cardiovascular disease in the population.
Methods and Results Clinical and laboratory data, as well as medical-technical
examinations were assessed from 15 010 individuals aged 35 to 74 years during a
highly standardized 5-hour visit at the study center of the population-based
Gutenberg Health Study. In total, the study sample comprised 287 VKA users and
14 564 VKA nonusers. Multivariable analysis revealed an independent association
between VKA intake and stiffness index (β=+2.54 m/s; [0.41/4.66]; P=0.019), ankle-
brachial index (β=-0.03; [-0.04/-0.01]; P<0.0001), intima-media thickness
(β=+0.03 mm [0.01/0.05]; P=0.0098), left ventricular ejection fraction (β=-4.02% [-
4.70/-3.33]; P<0.0001), E/E' (β=+0.04 [0.01/0.08]; P=0.014) left ventricular mass
(β=+5.34 g/m(2.7) [4.26/6.44]; P<0.0001), and humoral markers of cardiac function
and inflammation (midregional pro-atrial natriuretic peptide: β=+0.58 pmol/L
[0.50/0.65]; P<0.0001; midregional pro-adrenomedullin: β=+0.18 nmol/L [0.14/0.22];
P<0.0001; N-terminal pro B-type natriuretic peptide: β=+1.90 pg/mL [1.63/2.17];
P<0.0001; fibrinogen: β=+143 mg/dL [132/153]; P<0.0001; C-reactive protein:
β=+0.31 mg/L [0.20/0.43]; P<0.0001). Sensitivity analysis in the subsample of
participants with atrial fibrillation stratified by intake of VKA demonstrated
consistent and robust results. Genetic variants in CYP 2C9, CYP 4F2, and VKORC 1
were modulating effects of VKA on subclinical markers of cardiovascular disease.
Conclusions These data demonstrate negative effects of VKA on vascular and cardiac
phenotypes of subclinical cardiovascular disease, indicating a possible influence
on long-term disease development. These findings may be clinically relevant for the
provision of individually tailored antithrombotic therapy.
AD - 1 Preventive Cardiology and Preventive Medicine Center for Cardiology
University Medical Center Mainz Mainz Germany.
2 Center for Translational Vascular Biology (CTVB) University Medical Center Mainz
Mainz Germany.
3 Center for Thrombosis and Hemostasis University Medical Center Mainz Mainz
Germany.
4 DZHK (German Center for Cardiovascular Research) Partner Site Rhine-Main Mainz
Germany.
5 Center for Cardiology - Cardiology I University Medical Center Mainz Mainz
Germany.
6 Institute for Medical Biometry and Statistics University of Freiburg Germany.
7 Department of Psychosomatic Medicine and Psychotherapy University Medical Center
Mainz Mainz Germany.
8 Department of Ophthalmology University Medical Center Mainz Mainz Germany.
9 Clinic for General and Interventional Cardiology University Heart Centre Hamburg
Hamburg Germany.
10 DZHK (German Center for Cardiovascular Research) Partner Site
Hamburg/Kiel/Lübeck Hamburg Germany.
11 Institute for Clinical Chemistry and Laboratory Medicine University Medical
Center Mainz Mainz Germany.
12 Laboratory for Clinical Thrombosis and Hemostasis Department of Internal
Medicine Cardiovascular Research Institute Maastricht (CARIM) Maastricht University
Medical Center Maastricht The Netherlands.
AN - 30371151
AU - Eggebrecht, L.
AU - Prochaska, J. H.
AU - Schulz, A.
AU - Arnold, N.
AU - Jünger, C.
AU - Göbel, S.
AU - Laubert-Reh, D.
AU - Binder, H.
AU - Beutel, M. E.
AU - Pfeiffer, N.
AU - Blankenberg, S.
AU - Lackner, K. J.
AU - Spronk, H. M.
AU - Ten Cate, H.
AU - Münzel, T.
AU - Wild, P. S.
C2 - PMC6201416
DA - Sep 4
DO - 10.1161/jaha.118.008650
DP - NLM
ET - 2018/10/30
IS - 17
KW - Adrenomedullin/blood
Adult
Aged
Ankle Brachial Index
Asymptomatic Diseases
Atrial Natriuretic Factor/blood
C-Reactive Protein/metabolism
Cardiovascular Diseases/diagnostic imaging/*epidemiology/metabolism/physiopathology
Carotid Intima-Media Thickness
Female
Fibrinogen/metabolism
Germany
Humans
Male
Middle Aged
Phenprocoumon/*therapeutic use
Pulmonary Embolism/drug therapy
Risk Factors
*Stroke Volume
*Vascular Stiffness
Venous Thrombosis/drug therapy
*cardiovascular disease
*oral anticoagulation
*pharmacogenomic variants
*vitamin K antagonists
LA - eng
N1 - 2047-9980
Eggebrecht, Lisa
Prochaska, Jürgen H
Schulz, Andreas
Arnold, Natalie
Jünger, Claus
Göbel, Sebastian
Laubert-Reh, Dagmar
Binder, Harald
Beutel, Manfred E
Pfeiffer, Nobert
Blankenberg, Stefan
Lackner, Karl J
Spronk, Henri M
Ten Cate, Hugo
Münzel, Thomas
Wild, Philipp S
Journal Article
Observational Study
J Am Heart Assoc. 2018 Sep 4;7(17):e008650. doi: 10.1161/JAHA.118.008650.
PY - 2018
SN - 2047-9980
SP - e008650
ST - Intake of Vitamin K Antagonists and Worsening of Cardiac and Vascular
Disease: Results From the Population-Based Gutenberg Health Study
TI - Intake of Vitamin K Antagonists and Worsening of Cardiac and Vascular
Disease: Results From the Population-Based Gutenberg Health Study
VL - 7
ID - 2318
ER -
TY - JOUR
AB - This report is a case history of a 16-year-old highly trained athlete who
suffered from ventricular fibrillation during exhaustive physical activity. After
resuscitation and admission into hospital ECG revealed posterior wall infarction.
Thrombolytic therapy was advised and ST-segment elevation reversed. Within 48 h
cerebral edema evolved due to hypoxic brain damage and the subject deceased after
16 days despite prolonged maximum antiedematous therapy. Autopsy confirmed the
diagnosis of concentric myocardial hypertrophy (total heart weight 568 g) without
signs of coronary artery disease. Systemic inflammatory diseases and drug abuse
were ruled out by lab studies, evidence for viral infection was not found. Thus,
relative coronary insufficiency in regard to myocardial hypertrophy during
excessive athletic activity must be viewed as cause for the fatal arrhythmia.
AD - Department of Internal Medicine, General Hospital Cologne Holweide, Germany.
d0103573@smail.uni-koeln.de
AN - 11071059
AU - Ehses, W.
AU - Niklaus, K.
AU - Brockmann, M.
AU - Angenendt, W.
AU - Saborowski, F.
DA - Oct
DO - 10.1055/s-2000-7418
DP - NLM
ET - 2000/11/09
IS - 7
J2 - International journal of sports medicine
KW - Adolescent
Arrhythmias, Cardiac/*etiology
Cardiomegaly
Fatal Outcome
Humans
Male
Myocardial Infarction/*complications
*Sports
LA - eng
N1 - Ehses, W
Niklaus, K
Brockmann, M
Angenendt, W
Saborowski, F
Case Reports
Journal Article
Germany
Int J Sports Med. 2000 Oct;21(7):536-9. doi: 10.1055/s-2000-7418.
PY - 2000
SN - 0172-4622 (Print)
0172-4622
SP - 536-9
ST - Fatal arrhythmia in a juvenile athlete due to myocardial hypertrophy and
infarction
T2 - Int J Sports Med
TI - Fatal arrhythmia in a juvenile athlete due to myocardial hypertrophy and
infarction
VL - 21
ID - 2736
ER -
TY - JOUR
AB - OBJECTIVE: Atrial fibrillation (AF) is the most important risk factor for
ischemic stroke. Anticoagulation therapy can substantially decrease the risk of
stroke in patients with AF. The aim of our study was to investigate the patient's
comorbidities and management of patients with AF on the discharge. METHODS: From
5382 consecutive patients admitted in our institution between January 2005 and
March 2008, 525 (mean age 66.4+/- 11.4 years, 53.3% male) had AF upon discharge,
who were included in this retrospective study. Patients were divided in two groups
according to prescription of anticoagulation therapy at discharge. Continuous data
were compared between groups using a two-tailed unpaired Student t test. Discrete
variables were compared using Chi-square test or Fisher's exact probability test as
appropriate. Logistic regression analysis was used to identify the independent
clinical and echocardiographic predictors of prescribing oral anticoagulation
therapy. RESULTS: Associated comorbidities of AF in our patients were: ischemic
heart disease (21.4%), hypertensive heart disease (27.44%), valvular heart disease
(17.4%), congestive heart failure (47%), chronic obstructive pulmonary disease
(6.7%), and diabetes 14.3%). Of 525 patients 76% were discharged on beta-blockers,
67% on angiotensin converting enzyme inhibitors, 23% on digoxin, 16% on calcium
antagonists, 67% on diuretics, 72% on aspirin, and 27% on oral anticoagulant (OAC)
therapy, 11% were with both antithrombotics. Multivariate analysis showed that the
under-prescription of OAC therapy in patients with AF was independently associated
with elder age (OR=0.916, 95%CI 0.891-0.942, p<0.001), non-enlarged left atrium
(OR=1.148, 95%CI 1.100-1.198, p<0.001) and good left ventricular ejection fraction
(OR=0.970, 95%CI 0.948-0.993, p=0.011). CONCLUSIONS: Patients with atrial
fibrillation were mainly with ischemic, hypertensive heart disease and congestive
heart failure. Our study, suggests underuse of anticoagulation therapy. The
independent predictors of under prescription of anticoagulants in patients with
atrial fibrillation were elder age, non-enlarged left atrium, and good left
ventricular ejection fraction. Medical treatment with other groups of drugs for
atrial fibrillation and comorbidities seems to be according to current guidelines.
AD - Department of Internal Medicine, Faculty of Medicine, University of
Prishtina, Prishtina, Kosovo.
AN - 20150002
AU - Elezi, S.
AU - Qerkini, G.
AU - Bujupi, L.
AU - Shabani, D.
AU - Bajraktari, G.
DA - Feb
DO - 10.5152/akd.2010.008
DP - NLM
ET - 2010/02/13
IS - 1
J2 - Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology
KW - Aged
Atrial Fibrillation/complications/*drug therapy/epidemiology/physiopathology
Comorbidity
Electrocardiography
Female
Humans
Male
Middle Aged
Prevalence
Risk Assessment
Serbia
Stroke/complications/drug therapy/*epidemiology/physiopathology
LA - eng
N1 - 1308-0032
Elezi, Shpend
Qerkini, Gazmend
Bujupi, Liridon
Shabani, Driton
Bajraktari, Gani
Journal Article
Turkey
Anadolu Kardiyol Derg. 2010 Feb;10(1):36-40. doi: 10.5152/akd.2010.008.
PY - 2010
SN - 1302-8723
SP - 36-40
ST - Management and comorbidities of atrial fibrillation in patients admitted in
cardiology service in Kosovo-a single-center study
T2 - Anadolu Kardiyol Derg
TI - Management and comorbidities of atrial fibrillation in patients admitted in
cardiology service in Kosovo-a single-center study
VL - 10
ID - 2503
ER -
TY - JOUR
AB - BACKGROUND: Current guidelines recommend the use of electrocardiography (ECG)
in the evaluation of transient ischemic attack (TIA), but the data supporting its
value in acute management are sparse. OBJECTIVE: To determine whether ECG findings
are useful as independent predictors of short-term cardiac or neurologic
complications after TIA. METHODS: We included patients who presented to 1 of 16
emergency departments of a health maintenance organization in northern California
and received a diagnosis of TIA from March 1, 1997, through February 28, 1998, for
a 90-day follow-up. A cardiac event was defined as a hospitalization or a death due
to myocardial infarction, ventricular arrhythmia, heart failure, or unstable
angina. RESULTS: Among the 1327 patients with TIA for whom ECG findings were
available for diagnostic coding, cardiac events occurred in 2.9%, strokes in 10.9%,
recurrent TIAs in 13.7%, and deaths in 2.6% during 90-day follow-up. The ECG
findings disclosed a new diagnosis of atrial fibrillation in 28 (2.3%) of the 1200
patients with no history of this condition. The 90-day risk for a cardiac event was
greater in those who had any abnormal ECG findings (4.2% vs 0.6%; P<.001). This
association remained significant after adjustment for medical history and
examination findings (odds ratio, 6.9; 95% confidence interval, 1.6-29.5; P =.009).
Left ventricular hypertrophy, atrial fibrillation, and atrioventricular conduction
abnormalities were each independently associated with more than doubling of the
risk. The ECG abnormalities were not associated with risk for stroke or death.
CONCLUSIONS: Short-term cardiac morbidity is substantial after TIA.
Electrocardiographic findings disclose new atrial fibrillation in a significant
portion of patients with TIA and can identify a group of patients at a
substantially higher risk for short-term cardiac events.
AD - Department of Neurology, UCSF Box 0114, University of California, San
Francisco, 505 Parnassus Ave, Room M-798, San Francisco, CA 94143-0114, USA.
AN - 12223031
AU - Elkins, J. S.
AU - Sidney, S.
AU - Gress, D. R.
AU - Go, A. S.
AU - Bernstein, A. L.
AU - Johnston, S. C.
DA - Sep
DO - 10.1001/archneur.59.9.1437
DP - NLM
ET - 2002/09/12
IS - 9
J2 - Archives of neurology
KW - Adult
Aged
Cohort Studies
Emergency Medical Services
Female
Follow-Up Studies
Heart Diseases/epidemiology/*etiology/*physiopathology
Humans
Ischemic Attack, Transient/*complications/*physiopathology
Male
Middle Aged
Prognosis
Risk Factors
Stroke/epidemiology/etiology/physiopathology
LA - eng
N1 - Elkins, Jacob S
Sidney, Stephen
Gress, Daryl R
Go, Alan S
Bernstein, Allan L
Johnston, S Claiborne
Journal Article
United States
Arch Neurol. 2002 Sep;59(9):1437-41. doi: 10.1001/archneur.59.9.1437.
PY - 2002
SN - 0003-9942 (Print)
0003-9942
SP - 1437-41
ST - Electrocardiographic findings predict short-term cardiac morbidity after
T2 - Arch Neurol
TI - Electrocardiographic findings predict short-term cardiac morbidity after
VL - 59
ID - 2502
ER -
TY - JOUR
AB - Heart failure patients on durable left ventricular assist device support
experience improved survival, quality of life, and exercise capacity. The
complication rate, however, remains unacceptably high, although it has declined
with improvements in pump design, better patient selection, and greater
understanding of the pump physiology and flow dynamics. Most complications are
categorized as those related to the pump-patient interface or those related to
patient physiology. It is hoped that further engineering progress, and better
patient selection through risk stratification, will allow for left ventricular
assist device to be totally biocompatible and perform effectively, without
affecting biology and homeostasis of the different organ systems.
AD - Advanced Heart Failure and Cardiac Transplant, Division of Cardiovascular
Medicine, The Ohio State University Wexner Medical Center, 473 West 12th Avenue,
Suite 200 DHLRI, Columbus, OH 43221, USA. Electronic address:
Sitaramesh.emani@osumc.edu.
AN - 29907277
AU - Emani, S.
DA - Jul
DO - 10.1016/j.ccc.2018.03.003
DP - NLM
ET - 2018/06/17
IS - 3
J2 - Critical care clinics
KW - Aortic Valve Insufficiency/etiology
Heart Failure/etiology/*therapy
Heart-Assist Devices/*adverse effects
Humans
Infections/*etiology
Stroke/etiology
Thrombosis/*etiology
Ventricular Dysfunction, Left/therapy
Ventricular Dysfunction, Right/etiology
von Willebrand Diseases/*etiology
Complications
GI bleeding
Hemocompatibility
Infection
Neurologic events
LA - eng
N1 - 1557-8232
Emani, Sitaramesh
Journal Article
Review
United States
Crit Care Clin. 2018 Jul;34(3):465-477. doi: 10.1016/j.ccc.2018.03.003.
PY - 2018
SN - 0749-0704
SP - 465-477
ST - Complications of Durable Left Ventricular Assist Device Therapy
T2 - Crit Care Clin
TI - Complications of Durable Left Ventricular Assist Device Therapy
VL - 34
ID - 2381
ER -
TY - JOUR
AB - Hypertension is the single greatest contributor to human disease and
mortality affecting over 75 million people in the United States alone. Hypertension
is defined according to the American College of Cardiology as systolic blood
pressure (SBP) greater than 120 mm Hg and diastolic blood pressure (DBP) above 80
mm Hg measured on two separate occasions. While there are multiple medication
classes available for blood pressure control, fewer than 50% of hypertensive
patients maintain appropriate control. In fact, 0.5% of patients are refractory to
medical treatment which is defined as uncontrolled blood pressure despite treatment
with five classes of antihypertensive agents. With new guidelines to define
hypertension that will increase the incidence of hypertension world-wide, the
prevalence of refractory hypertension is expected to increase. Thus, investigation
into alternative methods of blood pressure control will be crucial to reduce
comorbidities such as higher risk of myocardial infarction, cardiovascular
accident, aneurysm formation, heart failure, coronary artery disease, end stage
renal disease, arrhythmia, left ventricular hypertrophy, intracerebral hemorrhage,
hypertensive enchaphelopathy, hypertensive retinopathy, glomerulosclerosis, limb
loss due to arterial occlusion, and sudden death. Recently, studies demonstrated
efficacious treatment of neurological diseases with deep brain stimulation (DBS)
for Tourette's, depression, intermittent explosive disorder, epilepsy, chronic
pain, and headache as these diseases have defined neurophysiology with anatomical
targets. Currently, clinical applications of DBS is limited to neurological
conditions as such conditions have well-defined neurophysiology and anatomy.
However, rapidly expanding knowledge about neuroanatomical controls of systemic
conditions such as hypertension are expanding the possibilities for DBS
neuromodulation. Within the central autonomic network (CAN), multiple regions play
a role in homeostasis and blood pressure control that could be DBS targets. While
the best defined autonomic target is the ventrolateral periaqueductal gray matter,
other targets including the subcallosal neocortex, subthalamic nucleus (STN),
posterior hypothalamus, rostrocaudal cingulate gyrus, orbitofrontal gyrus, and
insular cortex are being further characterized as potential targets. This review
aims to summarize the current knowledge regarding neurologic contribution to the
pathophysiology of hypertension, delineate the complex interactions between
neuroanatomic structures involved in blood pressure homeostasis, and then discuss
the potential for using DBS as a treatment for refractory hypertension.
AD - Department of Neurological Surgery, Neurological Institute, University
Hospitals Cleveland Medical Center, Cleveland, OH, United States.
AN - 30858796
AU - Ems, R.
AU - Garg, A.
AU - Ostergard, T. A.
AU - Miller, J. P.
C2 - PMC6397890
DO - 10.3389/fnins.2019.00093
DP - NLM
ET - 2019/03/13
J2 - Frontiers in neuroscience
KW - Brodmann area 25
deep brain stimulation
functional neurosurgery
hypertension
insular cortex
periaqueductal gray
rostral subcallosal neocortex
subthalamic nucleus
LA - eng
N1 - 1662-453x
Ems, Raleigh
Garg, Anisha
Ostergard, Thomas A
Miller, Jonathan P
Journal Article
Review
Front Neurosci. 2019 Feb 25;13:93. doi: 10.3389/fnins.2019.00093. eCollection 2019.
PY - 2019
SN - 1662-4548 (Print)
1662-453x
SP - 93
ST - Potential Deep Brain Stimulation Targets for the Management of Refractory
Hypertension
T2 - Front Neurosci
TI - Potential Deep Brain Stimulation Targets for the Management of Refractory
Hypertension
VL - 13
ID - 3117
ER -
TY - JOUR
AB - BACKGROUND AND PURPOSE: With the exception of atrial fibrillation (AF),
little scientific attention has been given the associations between cardiac
arrhythmias and incidence of stroke. We sought to study whether atrial and
ventricular arrhythmias assessed during a 24-hour ambulatory ECG registration are
associated with incidence of stroke. METHODS: The population-based cohort "Men Born
in 1914" was examined with 24-hour ambulatory ECG registrations at 68 years of age.
Four hundred two men without previous myocardial infarction or stroke were
included, and 236 of them had hypertension (>/=160/95 mm Hg or treatment).
Fourteen-year rates of stroke (fatal and nonfatal) and all-cause mortality were
updated from national and regional registers. Frequent or complex ventricular
arrhythmias was defined as Lown class 2 to 5. A high frequency of atrial ectopic
beats (AEB) was defined as the fifth quintile (ie, >/=218 AEB per 24 hours).
RESULTS: Fifty-eight men suffered a first stroke during the follow-up. Stroke rates
(per 1000 person-years) among men with AF (n=14), with frequent AEB (n=77), and
without AF or frequent AEB (n=311) were 34.5, 19.5, and 11.6, respectively. The
corresponding values among men with hypertension were 40.7, 32.3, and 14.7,
respectively. Frequent AEB (compared with absence of AF and frequent AEB) was
significantly associated with stroke among all men (relative risk=1.9; 95% CI, 1.02
to 3.4; P:=0.04) and among hypertensive men (relative risk=2.5; 95% CI, 1.3 to 4.8;
P:=0.009) after adjustments for potential confounders. The increased stroke rates
among men with Lown class 2 to 5 did not reach statistical significance.
CONCLUSIONS: A high frequency of AEB is associated with an increased incidence of
stroke.
AD - Department of Community Medicine, Malmö University Hospital (Sweden).
Gunnar.Engstrom@smi.mas.lu.se
AN - 11108750
AU - Engström, G.
AU - Hedblad, B.
AU - Juul-Möller, S.
AU - Tydén, P.
AU - Janzon, L.
DA - Dec
DO - 10.1161/01.str.31.12.2925
DP - NLM
ET - 2000/01/11
IS - 12
J2 - Stroke
KW - Aged
Arrhythmias, Cardiac/diagnosis/epidemiology
Atrial Premature Complexes/diagnosis/*epidemiology
Cause of Death
Comorbidity
Drug Resistance, Multiple
Electrocardiography, Ambulatory/statistics & numerical data
Humans
Incidence
Male
Prospective Studies
Registries
Risk Factors
Sampling Studies
Sex Factors
Stroke/diagnosis/*epidemiology/mortality
Sweden/epidemiology
LA - eng
N1 - 1524-4628
Engström, G
Hedblad, B
Juul-Möller, S
Tydén, P
Janzon, L
Journal Article
United States
Stroke. 2000 Dec;31(12):2925-9. doi: 10.1161/01.str.31.12.2925.
PY - 2000
SN - 0039-2499
SP - 2925-9
ST - Cardiac arrhythmias and stroke: increased risk in men with high frequency of
atrial ectopic beats
T2 - Stroke
TI - Cardiac arrhythmias and stroke: increased risk in men with high frequency of
atrial ectopic beats
VL - 31
ID - 2484
ER -
TY - JOUR
AB - Percutaneous transfemoral valvuloplasty was performed in 20 patients (aged
25-83 years; mean 62) with marked signs of aortic valve stenosis, some calcified,
others noncalcified. The transvalvar systolic pressure gradient was reduced from a
mean of 104 +/- 7 mm Hg to a mean of 46 +/- 4 mm Hg, the valvar opening area from
0.38 +/- 0.04 cm2 to 0.74 +/- 0.04 cm2. The result was judged to be unsatisfactory
in four patients and required aortic valve replacement after initially good results
from the balloon dilatation. Serious complications were reversible ventricular
fibrillation and reversible cerebral ischemia with partial hemiparesis in one
patient each. In three patients the femoral artery had to be repaired at the site
of puncture, twice the balloon ruptured without sequelae, once reversible
pericardial effusion occurred, and twice there were reactions to antibiotics given
after the procedure. Invasive re-catheterizations were performed in four patients,
at intervals of three months: no increase in pressure gradient was observed. The
results indicate that reduction of the transvalvar pressure gradient by 40 mm Hg
can produce rapid reversal of heart failure and a symptom-free state even in
patients who were already decompensated.
AN - 3595466
AU - Erdmann, E.
AU - Höfling, B.
DA - Jul 3
DO - 10.1055/s-2008-1068195
DP - NLM
ET - 1987/07/03
IS - 27
J2 - Deutsche medizinische Wochenschrift (1946)
KW - Adult
Aged
Aortic Valve Stenosis/complications/physiopathology/*therapy
Blood Pressure
Calcinosis/*complications
Dilatation/adverse effects/methods
Female
Humans
Male
Middle Aged
Pressure
LA - ger
N1 - Erdmann, E
Höfling, B
English Abstract
Journal Article
Germany
Dtsch Med Wochenschr. 1987 Jul 3;112(27):1067-72. doi: 10.1055/s-2008-1068195.
OP - Perkutane transfemorale Valvuloplastie der verkalkten und nicht verkalkten
Aortenklappe.
PY - 1987
SN - 0012-0472 (Print)
0012-0472
SP - 1067-72
ST - [Percutaneous transfemoral valvuloplasty of calcified and non-calcified
aortic valves]
T2 - Dtsch Med Wochenschr
TI - [Percutaneous transfemoral valvuloplasty of calcified and non-calcified
aortic valves]
VL - 112
ID - 3015
ER -
TY - JOUR
AB - The usefulness of pulmonary-artery cineangiocardiography (PACAC) to
demonstrate intracardiac thrombi in patients with cerebral infarctions of possible
embolic origin has been explored. PACAC was performed in 60 patients (mean age 74
years) with sudden onset of permanent neurological deficits in whom CT scan and CSF
analyses had excluded intracerebral hemorrhage. Opacification of the left atrium
was excellent in 52 (87%) investigations, acceptable in 7 and poor in 1. Among 33
patients with chronic atrial fibrillation, an atrial thrombus was demonstrated in 8
(24%) and a suspected thrombus in 3. Atrial clot was also demonstrated in a patient
with intermittent atrial fibrillation. In 4 out of 14 patients with previous
myocardial infarction, a ventricular thrombus was demonstrated. Ventricular clots
were detected in 2 of 46 patients without known previous myocardial infarction. No
major complications occurred during the investigation. PACAC can be to used in the
search for atrial or ventricular thrombi when cardiac source of a cerebral embolus
is suspected. About 1 out of 3 patients with atrial fibrillation has remaining
intracardiac thrombus after stroke.
AN - 6702417
AU - Eriksson, S.
AU - Osterman, G.
AU - Asplund, K.
AU - Hägg, E.
AU - Helmers, C.
AU - Lithner, F.
AU - Strand, T.
AU - Wester, P. O.
DA - Jan
DO - 10.1111/j.1600-0404.1984.tb07776.x
DP - NLM
ET - 1984/01/01
IS - 1
J2 - Acta neurologica Scandinavica
KW - Aged
Angiocardiography
Cineangiography
Female
Heart Atria
Heart Diseases/complications/*diagnostic imaging
Heart Ventricles
Humans
Intracranial Embolism and Thrombosis/*etiology
Male
Middle Aged
Pulmonary Artery
Thrombosis/*diagnostic imaging
LA - eng
N1 - Eriksson, S
Osterman, G
Asplund, K
Hägg, E
Helmers, C
Lithner, F
Strand, T
Wester, P O
Journal Article
Denmark
Acta Neurol Scand. 1984 Jan;69(1):27-33. doi: 10.1111/j.1600-0404.1984.tb07776.x.
PY - 1984
SN - 0001-6314 (Print)
0001-6314
SP - 27-33
ST - Pulmonary-artery cineangiocardiography to demonstrate cardiac thrombi in
patients with cerebral infarction
T2 - Acta Neurol Scand
TI - Pulmonary-artery cineangiocardiography to demonstrate cardiac thrombi in
patients with cerebral infarction
VL - 69
ID - 2944
ER -
TY - JOUR
AB - Ischemic stroke, a major complication of atrial fibrillation (AF), is
believed to result from atrial thrombus formation caused by ineffective atrial
contraction. Oral anticoagulant therapy effectively reduces the risk of ischemic
stroke in patients with AF; this therapy is recommended for patients with any
frequency or duration of AF and other risk factors for stroke, such as increased
age (>75 years), hypertension, prior stroke, left ventricular dysfunction,
diabetes, or heart failure. Recently published data comparing rate-control and
rhythm-control strategies in AF emphasized the importance of maintaining an
international normalized ratio higher than 2.0 during warfarin therapy and the need
for continuing anticoagulant therapy to prevent stroke in high-risk patients, even
if the strategy is rhythm control. Hemorrhagic complications can be minimized by
stringent control of the international normalized ratio (particularly in elderly
patients) and appropriate therapy for comorbidities such as hypertension, gastric
ulcer, and early-stage cancers. Undertreatment of patients with AF is a continuing
problem, particularly in the elderly population. Patients perceived as likely to be
noncompliant, such as the functionally impaired, are less likely to receive
warfarin therapy. However, stroke prevention with anticoagulants is cost-effective
and improves quality of life, despite the challenges of maintaining appropriate
anticoagulation with monitoring and warfarin dose titration. New medications in
development with more predictable dosing and fewer drug-drug interactions may
reduce the complexities of achieving optimal anticoagulation and increase the
practicality of long-term anticoagulant therapy for patients with AF at risk of
stroke.
AD - Department of Medicine, Drexel University College of Medicine, Philadelphia,
PA 19102, USA. mde22@drexel.edu
AN - 15244388
AU - Ezekowitz, M. D.
AU - Falk, R. H.
DA - Jul
DO - 10.4065/79.7.904
DP - NLM
ET - 2004/07/13
IS - 7
J2 - Mayo Clinic proceedings
KW - Aged
Anticoagulants/administration & dosage/adverse effects/*therapeutic use
Cerebral Hemorrhage/chemically induced
Humans
Warfarin/administration & dosage/adverse effects
LA - eng
N1 - Ezekowitz, Michael D
Falk, Rodney H
Journal Article
Review
England
Mayo Clin Proc. 2004 Jul;79(7):904-13. doi: 10.4065/79.7.904.
PY - 2004
SN - 0025-6196 (Print)
0025-6196
SP - 904-13
ST - The increasing need for anticoagulant therapy to prevent stroke in patients
with atrial fibrillation
T2 - Mayo Clin Proc
TI - The increasing need for anticoagulant therapy to prevent stroke in patients
with atrial fibrillation
VL - 79
ID - 2560
ER -
TY - JOUR
AB - BACKGROUND: Atrial fibrillation is the most common cardiac arrhythmia
associated with significant medical complications. We examined trends in the
medical therapy of atrial fibrillation in the United States from 1991 through 2000.
METHODS: Data from 1355 visits among patients with atrial fibrillation were
obtained from the National Ambulatory Medical Care Survey, a nationally
representative assessment of office-based practice. We assessed trends in
medication use for ventricular rate control (digoxin, beta-blockers, and calcium
channel blockers), sinus rhythm maintenance (class IA, IC, and III
antiarrhythmics), and thromboembolism prevention (oral anticoagulants and aspirin).
RESULTS: Overall rate control medication use decreased from 72% of visits in 1991-
1992 to 56% in 1999-2000 (P =.01 for trend) due to declining digoxin use (64% to
37%, P<.001 for trend). beta-Blocker and calcium channel blocker use remained
unchanged. Although there was no change in overall sinus rhythm medication use over
time, amiodarone hydrochloride use increased from 0.2% to 6.4% (P<.001 for trend),
while quinidine use decreased from 5.0% to 0.0% (P =.01 for trend). Oral
anticoagulant use increased (28% to 41%, P =.01 for trend), with the greatest
increase in patients aged 80 years and older (14% to 48%, P<.001 for trend).
Despite this, only 46.5% of patients at high risk for stroke were taking
anticoagulants in 1999-2000. CONCLUSIONS: Digoxin use in atrial fibrillation
decreased over time, without concomitant increases in beta-blocker or calcium
channel blocker use. Amiodarone replaced quinidine as the dominant sinus rhythm
medication. Although oral anticoagulant use increased over time, particularly in
the oldest patients, fewer than half of the patients at high risk for stroke were
anticoagulated.
AD - Massachusetts General Hospital, Boston, USA. mfang@medicine.ucsf.edu
AN - 14718322
AU - Fang, M. C.
AU - Stafford, R. S.
AU - Ruskin, J. N.
AU - Singer, D. E.
DA - Jan 12
DO - 10.1001/archinte.164.1.55
DP - NLM
ET - 2004/01/14
IS - 1
Adrenergic beta-Antagonists/administration & dosage
Age Factors
Aged
Aged, 80 and over
Anti-Arrhythmia Agents/*administration & dosage
Calcium Channel Blockers/administration & dosage
Drug Utilization/*trends
Female
Fibrinolytic Agents/*administration & dosage
Health Care Surveys
Humans
Male
Practice Patterns, Physicians'/trends
Risk Factors
United States
LA - eng
N1 - Fang, Margaret C
Stafford, Randall S
Ruskin, Jeremy N
Singer, Daniel E
5T32 PE11001-13/PE/BHP HRSA HHS/United States
Journal Article
United States
Arch Intern Med. 2004 Jan 12;164(1):55-60. doi: 10.1001/archinte.164.1.55.
PY - 2004
SN - 0003-9926 (Print)
0003-9926
SP - 55-60
ST - National trends in antiarrhythmic and antithrombotic medication use in atrial
fibrillation
TI - National trends in antiarrhythmic and antithrombotic medication use in atrial
fibrillation
VL - 164
ID - 2689
ER -
TY - JOUR
AB - The known risk of embolic events in patients with recurrent or chronic atrial
fibrillation makes it mandatory to recommend oral anticoagulation in patients with
rheumatic mitral valve disease, specially mitral stenosis to maintain an INR
between 2.0 and 3.0. If despite this treatment recurrent embolism occurs, the dose
of oral anticoagulants should be increased (INR between 2.5 and 3.5) or
dipyridamole (200 to 400 mg/day) or aspirin (160 to 320 mg/day) should be added to
dicoumarinic drugs. In patients that must be cardioverted either electrically or
pharmacologically and who have been on atrial fibrillation for more than 2 days,
oral anticoagulation should be maintained for 3-4 weeks before cardioversion and
for 3-4 weeks after regaining sinus rhythm. Transesophageal echocardiography may
enable us to identify the group of patients with low risk for an immediate
cardioversion. In patients under 60 years of age with atrial fibrillation and no
evidence of associated cardiovascular abnormality (lone atrial fibrillation) the
embolic risk is very low and antithrombotic therapy is probably not needed. In
subjects over 60 years of age with a low risk profile (absence of previous stroke,
heart failure or systemic hypertension) aspirin (300-325 mg a day) seems to offer
sufficient protection against embolic events. In patients at a higher embolic risk
(history of previous cerebral ischemic attacks, heart failure of left ventricular
dysfunction, systemic hypertension) oral anticoagulation unless contraindicated,
should be recommended (INR 2.0-3.0). The role of other antithrombotic agents such
as ticlopidine or triflusal to prevent embolic events in patients with atrial
fibrillation is unknown.
AD - Unidad de Arritmias, Servicio de Cardiología, Fundación Jiménez Díaz, Madrid.
AN - 8755695
AU - Farré, J.
AU - Navarro, F.
AU - Romero, J.
AU - Rivas, D.
AU - Manuel Rubio, J.
AU - Sanziani, L.
DP - NLM
ET - 1996/01/01
J2 - Revista espanola de cardiologia
Humans
Rheumatic Heart Disease/complications
Risk Factors
Thrombosis/*etiology/*prevention & control
LA - spa
N1 - Farré, J
Navarro, F
Romero, J
Rivas, D
Manuel Rubio, J
Sanziani, L
English Abstract
Journal Article
Review
Spain
Rev Esp Cardiol. 1996;49 Suppl 2:42-9.
OP - Terapéutica antitrombótica en la fibrilación auricular.
PY - 1996
SN - 0300-8932 (Print)
0300-8932
SP - 42-9
ST - [Antithrombotic therapy in atrial fibrillation]
T2 - Rev Esp Cardiol
TI - [Antithrombotic therapy in atrial fibrillation]
VL - 49 Suppl 2
ID - 3013
ER -
TY - JOUR
AB - BACKGROUND: Left atrial appendage closure (LAAC) represents the
interventional alternative to oral anticoagulation for stroke prevention in atrial
fibrillation (AF). The metabolism of acylcarnitines was shown to affect
cardiovascular diseases. This study evaluates the influence of successful LAAC on
the metabolism of acylcarnitines. METHODS: Patients undergoing successful LAAC were
enrolled prospectively. Peripheral blood samples for metabolomics measurements were
collected immediately before (i.e., index) and six months after LAAC (i.e., mid-
term). A targeted metabolomics analysis based on electrospray ionization-liquid
chromatography-mass spectrometry (ESI-LC-MS/MS) and MS/MS measurements was
performed. RESULTS: 44 patients with non-valvular AF (median CHA₂DS₂-VASc score 4,
median HAS-BLED score 4) and successful LAAC were included. Significant changes in
acylcarnitine levels were found in the total cohort, which were mainly attributed
to patients with impaired left ventricular and renal function, elevated amino-
terminal pro-brain natriuretic peptide (NT-proBNP) and diabetes mellitus. Adjusted
multivariable regression models revealed significant changes of five metabolites
over mid-term follow-up: C2, C14:1, C16, and C18:1 decreased significantly (each p
< 0.05); short-chain C5 acylcarnitine plasma levels increased significantly (p <
0.05). CONCLUSION: This study demonstrates that successful LAAC affects the
metabolism of acylcarnitines at mid-term follow-up. CLINICAL TRIAL REGISTRATION:
ClinicalTrials.gov Identifier: NCT02985463.
AD - First Department of Medicine, University Medical Center Mannheim, Faculty of
Medicine Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
christian.fastner@umm.de.
First Department of Medicine, University Medical Center Mannheim, Faculty of
martin.borggrefe@umm.de.
sartorius@stud.uni-heidelberg.de.
wenke@stud.uni-heidelberg.de.
siegfried.lang@umm.de.
goekhan.yuecel@umm.de.
katherine.sattler@umm.de.
jonas.rusnak@umm.de.
ahmad.saleh@umm.de.
christian.barth@umm.de.
Division of Cardiology and Angiology II, University Heart Center Freiburg-Bad
Krozingen, 79189 Bad Krozingen, Germany. kambis.mashayekhi@universitaets-
herzzentrum.de.
ursula.hoffmann@umm.de.
ibrahim.akin@umm.de.
AN - 29414920
AU - Fastner, C.
AU - Behnes, M.
AU - Sartorius, B.
AU - Wenke, A.
AU - Lang, S.
AU - Yücel, G.
AU - Sattler, K.
AU - Rusnak, J.
AU - Saleh, A.
AU - Barth, C.
AU - Mashayekhi, K.
AU - Hoffmann, U.
AU - Borggrefe, M.
AU - Akin, I.
C2 - PMC5855722
DA - Feb 7
DO - 10.3390/ijms19020500
DP - NLM
ET - 2018/02/08
IS - 2
J2 - International journal of molecular sciences
KW - Aged
Aged, 80 and over
Atrial Appendage/*surgery
Biomarkers/blood
Carnitine/*analogs & derivatives/blood/metabolism
Cohort Studies
Endovascular Procedures/*methods
Female
Humans
Male
Metabolomics
Prospective Studies
Regression Analysis
Stroke/blood/*prevention & control
Vascular Closure Devices
acylcarnitines
atrial fibrillation
left atrial appendage
left atrial appendage closure
LA - eng
N1 - 1422-0067
Fastner, Christian
Behnes, Michael
Sartorius, Benjamin
Wenke, Annika
Lang, Siegfried
Yücel, Gökhan
Sattler, Katherine
Rusnak, Jonas
Saleh, Ahmad
Barth, Christian
Mashayekhi, Kambis
Hoffmann, Ursula
Borggrefe, Martin
Akin, Ibrahim
Journal Article
Observational Study
Int J Mol Sci. 2018 Feb 7;19(2):500. doi: 10.3390/ijms19020500.
PY - 2018
SN - 1422-0067
ST - Interventional Left Atrial Appendage Closure Affects the Metabolism of
Acylcarnitines
T2 - Int J Mol Sci
TI - Interventional Left Atrial Appendage Closure Affects the Metabolism of
Acylcarnitines
VL - 19
ID - 2495
ER -
TY - JOUR
AB - Atrial fibrillation, the most frequent arrhythmia, has a growing incidence
with increasing age and the most important complication of the disease is
thromboembolic events that may be prevented by antivitamin K. They are the most
efficient therapeutic class for the prevention of these events but they are
associated with an increased haemorrhagic risk leading to a reduced prescription in
general practice. Optimisation of the management should be based on an individual
evaluation of the thromboembolic and haemorrhagic risks, taking into account age,
the presence of an associated heart disease, hypertension, diabetes, history of
cerebrovascular event, history of previous haemorrhagic event and the ability to
achieve a stable target INR. The challenge in ventricular arrhythmias lies in
identifying a high risk of sudden death, mainly related to ventricular
fibrillation. In patients with structural heart disease, left ventricular
dysfunction is the strongest predictor of sudden death. Non invasive markers such
as non sustained ventricular tachycardia, late ventricular potentials, decreased
heart rate variability and baroreflex sensitivity, and repolarization altemans are
further elements to assess risk. However, most of these markers have a poor
positive predictive value and a low specificity. In patients with normal hearts,
genetic predisposition may in the future identify high risk patients. The
electrophysiologic study with programmed ventricular stimulation remains a costly
and invasive method and only has a strong positive predictive value in ischemic
cardiomyopathy. More precise algorithms for risk stratification are thus needed
that may help the strategy of therapy with prophylactic implantable cardioverter
defibrillator in the future.
AD - Service de cardiologie B et laboratoire d'electrophysiologie cardiaque,
centre hospitalier universitaire Trousseau, 37044 Tours, France. lfau@med.univ-
tours.fr
AN - 16792027
AU - Fauchier, L.
AU - Robin, I.
AU - de Labriolle, A.
AU - Poret, P.
AU - Giraudeau, C.
AU - Cosnay, P.
AU - Babuty, D.
DA - Jun
DO - 10.1016/j.ancard.2005.12.001
DP - NLM
ET - 2006/06/24
IS - 3
J2 - Annales de cardiologie et d'angeiologie
KW - 4-Hydroxycoumarins/therapeutic use
Age Factors
Baroreflex/physiology
Diabetes Complications
Electrocardiography
Heart Diseases/complications
Hemorrhage/etiology/prevention & control
Humans
Indenes/therapeutic use
Risk Assessment
Risk Factors
Tachycardia, Ventricular/complications
Ventricular Dysfunction, Left/complications
Ventricular Fibrillation/complications
Vitamin K/antagonists & inhibitors/therapeutic use
LA - fre
N1 - Fauchier, L
Robin, I
de Labriolle, A
Poret, P
Giraudeau, C
Cosnay, P
Babuty, D
English Abstract
Journal Article
France
Ann Cardiol Angeiol (Paris). 2006 Jun;55(3):127-34. doi:
10.1016/j.ancard.2005.12.001.
OP - Stratification du risque dans les troubles du rythme auriculaire et
ventriculaire.
PY - 2006
SN - 0003-3928 (Print)
0003-3928
SP - 127-34
ST - [Risk stratification in atrial and ventricular arrhythmias]
T2 - Ann Cardiol Angeiol (Paris)
TI - [Risk stratification in atrial and ventricular arrhythmias]
VL - 55
ID - 2471
ER -
TY - JOUR
AN - 13821709
AU - Fauda, C.
DA - Jul-Aug
DP - NLM
ET - 1959/07/01
J2 - Minerva medicolegale; archivio di antropologia criminale, psichiatria, e
medicina legale
KW - *Heart
*Heart Block
*Medical Records
*Stroke
*Syndrome
*Ventricular Flutter
*HEART BLOCK/case reports
LA - ita
N1 - Fauda, c
Case Reports
Journal Article
Italy
Minerva Medicoleg. 1959 Jul-Aug;79:151-6.
PY - 1959
SN - 0026-4849 (Print)
0026-4849
SP - 151-6
ST - [Morgagni-Adams-Strokes syndrome. Apropos of two unusual cases of prolonged
arrest of the heart and of prolonged ventricular flutter]
T2 - Minerva Medicoleg
TI - [Morgagni-Adams-Strokes syndrome. Apropos of two unusual cases of prolonged
arrest of the heart and of prolonged ventricular flutter]
VL - 79
ID - 2774
ER -
TY - JOUR
AB - Obstructive sleep apnea syndrome (OSAS) is a chronic disease characterized by
recurrent episodes of partial or complete upper airway collapse and obstruction
during sleep, associated with intermittent oxygen desaturation, sleep
fragmentation, and symptoms of disruptive snoring and daytime sleepiness.
Increasing focus is being placed on the relationship between OSAS and all-cause and
cardiovascular disease-related mortality, but it still largely unclear whether this
association is causative or simply speculative and epidemiological. Basically,
reliable clinical evidence supports the hypothesis that OSAS might be associated
with essential and resistant hypertension, as well as with an incremental risk of
developing stroke, cardiac rhythm perturbations (e.g., atrial fibrillation,
bradyarrhythmias, supraventricular and ventricular arrhythmias), coronary artery
disease, acute myocardial infarction, and heart failure. Although it is still
unclear whether OSAS might represent an independent risk factor for several acute
or chronic conditions, or rather might trigger cardiovascular disease in the
presence of traditional cardiovascular risk factors (e.g., obesity, diabetes, and
dyslipidemia), there is a plausible biological background underlying this
association, in that most of the mechanisms implicated in the pathogenesis of OSAS
(i.e., hypoxia, hypercapnia, negative intrathoracic pressure, micro-arousal,
sympathetic hyperactivity, metabolic and hormonal changes, oxidative stress,
phlogosis, endothelial dysfunction, hypercoagulability, and genetic predisposition)
might also be involved in the pathogenesis of cardiovascular disorders. In this
article we discuss the different aspects of the relationship between OSAS and
pathogenically different conditions such as systemic hypertension, coronary artery
disease, stroke, metabolic abnormalities, arrhythmias, and heart failure, and we
also discuss the kaleidoscope of phenomena implicated in the pathogenesis of this
challenging disease.
AD - Sezione di Medicina interna C, Dipartimento di Scienze Biomediche e
Chirurgiche, Università di Verona, Verona, Italy. cristiano.fava@med.lu.se
AN - 21455862
AU - Fava, C.
AU - Montagnana, M.
AU - Favaloro, E. J.
AU - Guidi, G. C.
AU - Lippi, G.
DA - Apr
DO - 10.1055/s-0031-1273092
DP - NLM
ET - 2011/04/02
IS - 3
J2 - Seminars in thrombosis and hemostasis
KW - Animals
Arousal
Cardiovascular Diseases/*etiology/physiopathology
Continuous Positive Airway Pressure
Diabetes Mellitus, Type 2/etiology
Female
Glucose/metabolism
Humans
Hypercapnia/etiology
Hypoxia/etiology
Insulin Resistance
Male
Metabolic Syndrome/etiology
Sleep Apnea, Obstructive/*complications/physiopathology
Stroke/etiology
LA - eng
N1 - 1098-9064
Fava, Cristiano
Montagnana, Martina
Favaloro, Emmanuel J
Guidi, Gian Cesare
Lippi, Giuseppe
Journal Article
Review
United States
Semin Thromb Hemost. 2011 Apr;37(3):280-97. doi: 10.1055/s-0031-1273092. Epub 2011
Mar 31.
PY - 2011
SN - 0094-6176
SP - 280-97
ST - Obstructive sleep apnea syndrome and cardiovascular diseases
T2 - Semin Thromb Hemost
TI - Obstructive sleep apnea syndrome and cardiovascular diseases
VL - 37
ID - 2602
ER -
TY - JOUR
AB - We performed unenhanced computed tomographic scans on 141 asymptomatic
patients with nonvalvular atrial fibrillation. Thirty-six patients (26%) had
hypodense areas consistent with cerebral infarction. The majority of these were
small deep infarcts, seen in 29 patients (21%), but 13 patients (9%) had cortical
or large deep infarctions. Twelve patients had more than one infarct on computed
tomographic scan. Increasing age and increased left atrial diameter were the only
clinical features associated with asymptomatic infarction. Patients older than 65
years with a left atrial diameter greater than 5.0 cm (n = 23) had a 52% prevalence
of asymptomatic infarction. Patients younger than 65 years with a left atrial
diameter less than 5.0 cm (n = 38) had an 11% prevalence of silent infarction.
Patients with only one of these risk factors (n = 72) had a 24% prevalence of
silent infarction. Infarction was more common in those with chronic (34%) as
opposed to intermittent (22%) nonvalvular atrial fibrillation, but this difference
was not significant. Hypertension, diabetes, duration of atrial fibrillation,
congestive heart failure, history of myocardial infarction, and echocardiographic
evidence of left ventricular dysfunction were not associated with asymptomatic
infarction. A history of hypertension was present in only 35% of our patients with
small-deep asymptomatic infarction, similar to the percentage in patients without
stroke. Asymptomatic cerebral infarction is common in nonvalvular atrial
fibrillation. The association with enlarged left atria and the lack of correlation
with major cerebrovascular risk factors suggests a cardioembolic mechanism. Further
study is needed to determine the functional and prognostic significance of these
strokes.
AD - Department of Neurology, Arizona Health Sciences Center, Tucson 85724.
AN - 2241443
AU - Feinberg, W. M.
AU - Seeger, J. F.
AU - Carmody, R. F.
AU - Anderson, D. C.
AU - Hart, R. G.
AU - Pearce, L. A.
DA - Nov
DP - NLM
ET - 1990/11/01
IS - 11
KW - Aged
Cerebral Infarction/diagnostic imaging/*epidemiology/etiology
Cerebrovascular Disorders/prevention & control
Female
Humans
Male
Prevalence
Regression Analysis
LA - eng
N1 - Feinberg, W M
Seeger, J F
Carmody, R F
Anderson, D C
Hart, R G
Pearce, L A
R01 NS-24224/NS/NINDS NIH HHS/United States
Clinical Trial
Comparative Study
Journal Article
United States
Arch Intern Med. 1990 Nov;150(11):2340-4.
PY - 1990
SN - 0003-9926 (Print)
0003-9926
SP - 2340-4
ST - Epidemiologic features of asymptomatic cerebral infarction in patients with
nonvalvular atrial fibrillation
TI - Epidemiologic features of asymptomatic cerebral infarction in patients with
nonvalvular atrial fibrillation
VL - 150
ID - 2538
ER -
TY - JOUR
AB - BACKGROUND: Cardiovascular complications occur in 10% to 15% of patients
after major lung resection. We evaluated the utility of a revised scoring system
(thoracic revised cardiac risk index; ThRCRI) in identifying patients at increased
risk for major cardiovascular complications. METHODS: We analyzed outcomes from the
Society of Thoracic Surgeons General Thoracic Database for the period 2003 to 2011
for elective major lung resection. The ThRCRI risk score was based on weighted
values for serum creatinine, coronary artery disease, cerebrovascular disease, and
extent of lung resection, and was stratified into the following 4 risk categories:
0 (A); 1 to 1.5 (B); 2 to 2.5 (C); and >2.5 (D). Major cardiovascular complications
included myocardial infarction, adult respiratory distress syndrome, ventricular
arrhythmia requiring treatment, and all-cause death. RESULTS: A total of 26,085
patients (mean age 65.4±11.4 years; 51.3% men) underwent lobectomy (21,679; 83.2%),
bilobectomy (1,446; 5.5%) or pneumonectomy (1,697; 6.5%). Major cardiovascular
complications occurred in 1,125 patients (4.3%). ThRCRI scores in patients without
and with major cardiovascular complications were 0.6±0.9 and 1.1±1.1 (p<0.0001).
Score categories yielded incremental risks of major cardiovascular complications
(A: 2.9%; B: 5.8%; C: 11.9%; D: 11.1%; p<0.0001). CONCLUSIONS: The ThRCRI score
stratified risk moderately well for major postoperative cardiovascular events after
major lung resection. Use of this scoring system might help in identifying patients
who would benefit from additional preoperative evaluation and from closer
perioperative monitoring.
AD - Department of Surgery, The University of Chicago, Chicago, Illinois.
Electronic address: mferguso@surgery.bsd.uchicago.edu.
Department of Biostatistics and Bioinformatics, Duke University, Durham, North
Carolina.
Department of Surgery, University of Colorado Denver School of Medicine, Denver,
Colorado.
Department of Thoracic Surgery, Hospital Universitario de Salamanca, Salamanca,
Spain.
Division of Thoracic Surgery, St. James's University Hospital, Leeds, UK.
AN - 24565405
AU - Ferguson, M. K.
AU - Saha-Chaudhuri, P.
AU - Mitchell, J. D.
AU - Varela, G.
AU - Brunelli, A.
DA - Apr
DO - 10.1016/j.athoracsur.2013.12.032
DP - NLM
ET - 2014/02/26
IS - 4
KW - Aged
Cardiovascular Diseases/*etiology
Female
Humans
Lung Neoplasms/*surgery
Male
Middle Aged
Pneumonectomy/*adverse effects
Prognosis
LA - eng
N1 - 1552-6259
Ferguson, Mark K
Saha-Chaudhuri, Paramita
Mitchell, John D
Varela, Gonzalo
Brunelli, Alex
Journal Article
Validation Study
Netherlands
Ann Thorac Surg. 2014 Apr;97(4):1135-40. doi: 10.1016/j.athoracsur.2013.12.032.
Epub 2014 Feb 22.
PY - 2014
SN - 0003-4975
SP - 1135-40
ST - Prediction of major cardiovascular events after lung resection using a
modified scoring system
TI - Prediction of major cardiovascular events after lung resection using a
modified scoring system
VL - 97
ID - 3137
ER -
TY - JOUR
AB - BACKGROUND: Since atrial fibrillation (AF) may be undiagnosed when
asymptomatic and paroxysmal, we aimed to investigate the incidence and determinants
of silent AF in patients with acute ischemic stroke or transient ischemic attack
(TIA). METHODS: Consecutive patients admitted to the Stroke Unit of the University
Hospital of Dijon, France, for acute ischemic stroke or TIA were prospectively
enrolled from March to December 2012. Silent AF was assessed by continuous
electrocardiography (ECG) monitoring for 24 h after admission. An echocardiography
was performed at day 2 ± 1 to measure left ventricular ejection fraction (LVEF) and
left auricular (LA) dimensions. RESULTS: Among the 187 patients included, 19 (10%)
developed silent AF. Patients with silent AF were markedly older (76 vs. 66 years,
p < 0.002), with lower creatinine levels (90 vs. 80 µmol/l, p = 0.030) and were
less often smokers (5 vs. 24%, p = 0.058) than patients without silent AF. They
also showed a trend towards more frequent hypertension and a recent history of
infection. Patients with silent AF had a larger indexed LA volume (37.4 vs. 30.8
ml/m(3), p = 0.057) and LA diameter (23.2 vs. 20.8 mm/m(2), p = 0.059). LVEF in the
two groups was similar. In multivariate analysis, only age remained an independent
estimate of silent AF. CONCLUSION: Silent AF detected by continuous ECG monitoring
is common and closely associated with older age. Further studies are needed to
investigate the interest of systematically screening for silent AF for secondary
prevention after ischemic stroke/TIA.
AD - Cardiology Department, CHU Dijon, Dijon, France.
AN - 24685765
AU - Fernandez, V.
AU - Béjot, Y.
AU - Zeller, M.
AU - Hamblin, J.
AU - Daubail, B.
AU - Jacquin, A.
AU - Maza, M.
AU - Touzery, C.
AU - Cottin, Y.
AU - Giroud, M.
DO - 10.1159/000357561
DP - NLM
ET - 2014/04/02
IS - 5-6
KW - Age Factors
Aged
Atrial Fibrillation/diagnosis/*epidemiology/*physiopathology
Brain Ischemia/epidemiology
Creatinine/blood
Electrocardiography
Female
Hospitalization
Humans
Ischemic Attack, Transient/*epidemiology
Male
Prognosis
Prospective Studies
ROC Curve
LA - eng
N1 - 1421-9913
Fernandez, Vanessa
Béjot, Yannick
Zeller, Marianne
Hamblin, Joëlle
Daubail, Benoit
Jacquin, Agnes
Maza, Maud
Touzery, Claude
Cottin, Yves
Giroud, Maurice
Journal Article
Switzerland
Eur Neurol. 2014;71(5-6):313-8. doi: 10.1159/000357561. Epub 2014 Mar 26.
PY - 2014
SN - 0014-3022
SP - 313-8
ST - Silent atrial fibrillation after ischemic stroke or transient ischemic
attack: interest of continuous ECG monitoring
T2 - Eur Neurol
TI - Silent atrial fibrillation after ischemic stroke or transient ischemic
attack: interest of continuous ECG monitoring
VL - 71
ID - 2328
ER -
TY - JOUR
AB - INTRODUCTION: Cardiac arrhythmias are frequent in acute stroke. Stroke units
are widely equipped with cardiac monitoring systems. Pre-existing heart diseases
and heart-brain interactions may be implicated in causing cardiac arrhythmias in
acute stroke. This article analyses cardiac arrhythmias detected in patients
hospitalised in a stroke unit. METHOD: Prospective observational study of
consecutive patients admitted to a stroke unit with cardiac monitoring. We
collected clinical data from patients and the characteristics of their cardiac
arrhythmias over a 1-year period (2013). Time of arrhythmia onset, associated
predisposing factors, and the therapeutic decisions made after detection of
arrhythmia were examined. All patients underwent continuous cardiac monitoring
during no less than 48hours. RESULTS: Of a total of 332 patients admitted,
significant cardiac arrhythmias occurred in 98 patients (29.5%) during their stay
in the stroke unit. Tachyarrhythmia (ventricular tachyarrhythmias, supraventricular
tachyarrhythmias, complex ventricular ectopy) was present in 90 patients (27.1%);
bradyarrhythmia was present in 13 patients (3.91%). Arrhythmias were independently
associated with larger size of brain lesion and older age. In 10% of the patient
total, therapeutic actions were taken after detection of significant cardiac
arrhythmias. Most events occurred within the first 48hours after stroke unit
admission. CONCLUSIONS: Systematic cardiac monitoring in patients with acute stroke
is useful for detecting clinically relevant cardiac arrhythmias. Incidence of
arrhythmia is higher in the first 48hours after stroke unit admission. Age and
lesion size were predicted appearance of arrhythmias. Detection of cardiac
arrhythmias in a stroke unit has important implications for treatment.
AD - Servicio de Neurología, Complejo Asistencial Universitario de León, León,
España. Electronic address: sfmenendez@gmail.com.
Servicio de Neurología, Complejo Asistencial Universitario de León, León, España.
Servicio de Cardiología, Complejo Asistencial Universitario de León, León, España.
AN - 25976944
AU - Fernández-Menéndez, S.
AU - García-Santiago, R.
AU - Vega-Primo, A.
AU - González Nafría, N.
AU - Lara-Lezama, L. B.
AU - Redondo-Robles, L.
AU - Montes-Montes, M.
AU - Riveira-Rodríguez, M. C.
AU - Tejada-García, J.
DA - Jun
DO - 10.1016/j.nrl.2015.03.013
DP - NLM
ET - 2015/05/16
IS - 5
J2 - Neurologia (Barcelona, Spain)
KW - Age Factors
Aged
Arrhythmias, Cardiac/*epidemiology/etiology
Electrocardiography
Female
Hospitalization
Humans
Incidence
Male
Monitoring, Physiologic/*methods
Prospective Studies
Spain/epidemiology
Stroke/*complications/diagnostic imaging
Arritmias cardiacas
Cardiac arrhythmias
Cardiac monitoring
Consecuencias terapéuticas
Ictus
Monitorización cardiaca
Stroke
Stroke unit
Telemetry
Telemetría
Therapeutic implications
Unidad de ictus
LA - eng
spa
N1 - 1578-1968
Fernández-Menéndez, S
García-Santiago, R
Vega-Primo, A
González Nafría, N
Lara-Lezama, L B
Redondo-Robles, L
Montes-Montes, M
Riveira-Rodríguez, M C
Tejada-García, J
Journal Article
Observational Study
Spain
Neurologia. 2016 Jun;31(5):289-95. doi: 10.1016/j.nrl.2015.03.013. Epub 2015 May
12.
OP - Arritmias cardiacas en la unidad de ictus: análisis de los datos de la
monitorización cardiaca.
PY - 2016
SN - 0213-4853
SP - 289-95
ST - Cardiac arrhythmias in stroke unit patients. Evaluation of the cardiac
monitoring data
T2 - Neurologia
TI - Cardiac arrhythmias in stroke unit patients. Evaluation of the cardiac
monitoring data
VL - 31
ID - 2349
ER -
TY - JOUR
AB - BACKGROUND: Stroke can occur after myocardial infarction (MI) in the absence
of atrial fibrillation (AF). OBJECTIVES: This study sought to identify risk factors
(excluding AF) for the occurrence of stroke and to develop a calibrated and
validated stroke risk score in patients with MI and heart failure (HF) and/or
systolic dysfunction. METHODS: The datasets included in this pooling initiative
were derived from 4 trials: CAPRICORN (Effect of Carvedilol on Outcome After
Myocardial Infarction in Patients With Left Ventricular Dysfunction), OPTIMAAL
(Optimal Trial in Myocardial Infarction With Angiotensin II Antagonist Losartan),
VALIANT (Valsartan in Acute Myocardial Infarction Trial), and EPHESUS (Eplerenone
Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study);
EPHESUS was used for external validation. A total of 22,904 patients without AF or
oral anticoagulation were included in this analysis. The primary outcome was
stroke, and death was treated as a "competing risk." RESULTS: During a median
follow-up of 1.9 years (interquartile range: 1.3 to 2.7 years), 660 (2.9%) patients
had a stroke. These patients were older, more often female, smokers, and
hypertensive; they had a higher Killip class; a lower estimated glomerular
filtration rate; and a higher proportion of MI, HF, diabetes, and stroke histories.
The final stroke risk model retained older age, Killip class 3 or 4, estimated
glomerular filtration rate ≤45 ml/min/1.73 m(2), hypertension history, and previous
stroke. The models were well calibrated and showed moderate to good discrimination
(C-index = 0.67). The observed 3-year event rates increased steeply for each
sextile of the stroke risk score (1.8%, 2.9%, 4.1%, 5.6%, 8.3%, and 10.9%,
respectively) and were in agreement with the expected event rates. CONCLUSIONS:
Readily accessible risk factors associated with the occurrence of stroke were
identified and incorporated in an easy-to-use risk score. This score may help in
the identification of patients with MI and HF and a high risk for stroke despite
their not presenting with AF.
AD - National Institute of Health and Medical Research (INSERM), Center for
Clinical Multidisciplinary Research 1433, INSERM U1116, University of Lorraine,
Regional University Hospital of Nancy, French Clinical Research Infrastructure
Network (F-CRIN) Investigation Network Initiative-Cardiovascular and Renal Clinical
Trialists, Nancy, France; Department of Physiology and Cardiothoracic Surgery,
Cardiovascular Research and Development Unit, Faculty of Medicine, University of
Porto, Porto, Portugal.
National Institute of Health and Medical Research (INSERM), Center for Clinical
Multidisciplinary Research 1433, INSERM U1116, University of Lorraine, Regional
University Hospital of Nancy, French Clinical Research Infrastructure Network (F-
CRIN) Investigation Network Initiative-Cardiovascular and Renal Clinical Trialists,
Nancy, France.
Department of Biostatistics, London School of Hygiene & Tropical Medicine, London,
United Kingdom.
Duke Clinical Research Institute, Duke University, Durham, North Carolina;
Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta,
Canada.
Division of Cardiovascular Medicine, Brigham & Women's Hospital, Harvard Medical
School, Boston, Massachusetts.
BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland,
United Kingdom.
Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, Scotland,
United Kingdom.
Department of Medicine, University of Michigan School of Medicine, Ann Arbor,
Michigan.
Department of Cardiology, University of Bergan, Stavanger University Hospital,
Stavanger, Norway.
National Institute of Health and Medical Research (INSERM), Center for Clinical
Multidisciplinary Research 1433, INSERM U1116, University of Lorraine, Regional
University Hospital of Nancy, French Clinical Research Infrastructure Network (F-
CRIN) Investigation Network Initiative-Cardiovascular and Renal Clinical Trialists,
Nancy, France. Electronic address: f.zannad@chru-nancy.fr.
AN - 29447733
AU - Ferreira, J. P.
AU - Girerd, N.
AU - Gregson, J.
AU - Latar, I.
AU - Sharma, A.
AU - Pfeffer, M. A.
AU - McMurray, J. J. V.
AU - Abdul-Rahim, A. H.
AU - Pitt, B.
AU - Dickstein, K.
AU - Rossignol, P.
AU - Zannad, F.
DA - Feb 20
DO - 10.1016/j.jacc.2017.12.011
DP - NLM
ET - 2018/02/16
IS - 7
KW - Aged
*Atrial Fibrillation
Carvedilol/pharmacology/therapeutic use
Female
Follow-Up Studies
Humans
Male
Middle Aged
Myocardial Infarction/drug therapy/epidemiology/*physiopathology
Risk Factors
Stroke/drug therapy/epidemiology/*physiopathology
Stroke Volume/drug effects/*physiology
Vasodilator Agents/pharmacology/therapeutic use
*heart failure
*myocardial infarction
*risk score
*stroke
LA - eng
N1 - 1558-3597
Ferreira, João Pedro
Girerd, Nicolas
Gregson, John
Latar, Ichraq
Sharma, Abhinav
Pfeffer, Marc A
McMurray, John J V
Abdul-Rahim, Azmil H
Pitt, Bertram
Dickstein, Kenneth
Rossignol, Patrick
Zannad, Faiez
High-Risk Myocardial Infarction Database Initiative
MR/N003403/1/MRC_/Medical Research Council/United Kingdom
Journal Article
United States
J Am Coll Cardiol. 2018 Feb 20;71(7):727-735. doi: 10.1016/j.jacc.2017.12.011.
PY - 2018
SN - 0735-1097
SP - 727-735
ST - Stroke Risk in Patients With Reduced Ejection Fraction After Myocardial
Infarction Without Atrial Fibrillation
TI - Stroke Risk in Patients With Reduced Ejection Fraction After Myocardial
Infarction Without Atrial Fibrillation
VL - 71
ID - 2307
ER -
TY - JOUR
AB - The most disabling consequence of atrial fibrillation (AF) is stroke. In the
elderly, AF is the single most important cause of stroke. The risk of stroke is
increased at least 6-fold in subjects with AF. Strokes in patients with AF are in
general severe, associated with higher risk of fatality and prone to early and
long-term recurrence. The cardiac origin of stroke can be strongly suspected by
anamnesis, clinical examination and findings on neuroimaging. Paroxysmal AF is an
important cause of brain embolism, that is often difficult to document. Risk
factors for stroke in AF include: previous embolism (including previous transient
ischaemic attack (TIA), or ischaemic stroke), age >65 years, structural cardiac
disease, rheumatic or other significant valvular heart disease, valvular artificial
prosthesis, hypertension, heart failure and significant left ventricular systolic
dysfunction, diabetes and coronary disease. All AF patients with TIA or stroke have
a formal indication for long-term anticoagulation. Only patients without risk
factors or with contraindications to warfarin should be put on aspirin. Treating 1
000 patients with AF for 1 year with oral anticoagulants rather than aspirin would
prevent 23 ischaemic strokes while causing 9 major bleedings. Despite its enormous
preventive potential, oral anticoagulants are underused in AF, because treating
physicians often have lack of knowledge about trials and guidelines, underestimate
the benefits and overestimate the risks associated with continuous oral
anticoagulation. The introduction of anticoagulants that do not need frequent
control tests, such as ximelagatran, will increase the proportion of AF patients
with risk factors for stroke who are anticoagulated. There is no evidence to
support routine immediate anticoagulation in acute ischeamic stroke associated with
AF.
AD - Stroke Unit, Neurology Service, Santa Maria Hospital, Faculty of Medicine,
University of Lisbon, Lisbon, Portugal. jmferro@fm.ul.pt
AN - 15194993
AU - Ferro, J. M.
DA - Apr
DP - NLM
ET - 2004/06/15
IS - 2
KW - Adult
Age Factors
Aged
Anticoagulants/administration & dosage/classification/therapeutic use
Atrial Fibrillation/blood/*complications/diagnostic imaging/therapy
Brain Ischemia/diagnosis/epidemiology/etiology/prevention & control
Comorbidity
Diagnostic Imaging
Fibrinolytic Agents/administration & dosage/therapeutic use
Humans
Intracranial Embolism/diagnosis/epidemiology/*etiology/prevention & control
Middle Aged
Risk Factors
Ultrasonography
LA - eng
N1 - Ferro, J M
Journal Article
Review
Italy
Minerva Cardioangiol. 2004 Apr;52(2):111-24.
PY - 2004
SN - 0026-4725 (Print)
0026-4725
SP - 111-24
ST - Atrial fibrillation and cardioembolic stroke
TI - Atrial fibrillation and cardioembolic stroke
VL - 52
ID - 2851
ER -
TY - JOUR
AB - The present study has been devoted to the analysis of 120 patients presenting
with reversible focal cerebral ischemia without conventional signs of cardiopathy
and/or relevant atherosclerotic disease. In 77% of the patients vascular risk
factors, such as hypertension or hyperlipemia, were present. In 23% of the
patients, no abnormal finding was discovered at clinical, hematochemical and
cardiological examinations. In these patients a further cardiological evaluation
was performed with echocardiography. Dynamic electrocardiography was performed in
52 patients. Echocardiography and dynamic electrocardiography revealed the
occurrence of 6 cases of mitral valve prolapse (MVP), 2 cases of frequent premature
ventricular beats, and 1 proximal atrial arrhythmia. All 6 cases of MVP were
detected in the subgroups of patients without vascular risk factors. In our
patients younger than 45 years, the relative frequency of MVP attains 21.5%. This
study confirms that MVP has to be regarded as a risk factor for focal cerebral
ischemia in young patients.
AN - 6884393
AU - Fieschi, C.
AU - Francia, A.
AU - Allori, L.
AU - Argentino, C.
AU - Bernardi, S.
AU - Bertazzoni, G.
AU - Carpinteri, F.
AU - Di Piero, V.
AU - Ferroluzzi, M.
AU - Lenzi, G. L.
AU - Prencipe, M.
AU - Servi, M.
AU - Zanette, E.
DO - 10.1159/000115566
DP - NLM
ET - 1983/01/01
IS - 4
KW - Adult
Aged
Arrhythmias, Cardiac/diagnosis
*Echocardiography
Female
Humans
Ischemic Attack, Transient/*etiology
Male
Middle Aged
Mitral Valve Prolapse/*complications/diagnosis
Risk
LA - eng
N1 - Fieschi, C
Francia, A
Allori, L
Argentino, C
Bernardi, S
Bertazzoni, G
Carpinteri, F
Di Piero, V
Ferroluzzi, M
Lenzi, G L
Prencipe, M
Servi, M
Zanette, E
Journal Article
Switzerland
Eur Neurol. 1983;22(4):233-9. doi: 10.1159/000115566.
PY - 1983
SN - 0014-3022 (Print)
0014-3022
SP - 233-9
ST - Mitral valve prolapse as a risk factor for TIA. A study with echocardiography
and dynamic ECG
T2 - Eur Neurol
TI - Mitral valve prolapse as a risk factor for TIA. A study with echocardiography
and dynamic ECG
VL - 22
ID - 2730
ER -
TY - JOUR
AB - We have studied a series of 330 Holter recordings (HR) (including 5 double
observations) 189 men and 136 women, mean age 58,4 years Old. The analysis of this
series shows that: --105 HR were performed on patients with focal ischemia attacks
of suputed embolic origin; the HRT was positive in 35 patients (33 p. 100) with 25
supraventricular arrhythmias (SVA) 16 ventricular arrhythmias, associated in 9
cases, and 3 conduction blocks second degrees type 2. These arrhythmias are rare in
patients under 40, increasing with age, and reaching 53 p. 100 in patients greater
than 70 years. --86 HR were performed in ischemic heart disease (IHD): 52 HR for ST
segment analysis, positive in 5 cases, and coexisting with chest pain in 4 cases;
34 HR for detecting arrhythmias in IHD, positive in 18 cases with 14 VA and 4 SVA.
In 83 p. 100 the arrhythmias occur without IHD. They were positive in 70 cases,
with 49 SVA, 34 VA, associated in 17 cases, and 4 blocks second degrees type 2.
--10 cardiomyopathies were recorded; the HR was positive in 6, with 4 SVA, 3 VA
associated in 1 case. --8 mitral valve prolapses were recorded with 5 VA and 1 SVA.
In conclusion, the HR was positive in 45 p. 100 of the cases, and show especially
the great incidence of asymptomatic VA in patients with IHD.
AN - 6414410
AU - Fillette, F.
AU - Ducardonnet, A.
AU - Lebrun, S.
AU - Fontaine, G.
AU - Grosgogeat, Y.
DA - Jun
DP - NLM
ET - 1983/06/01
IS - 6
KW - Adolescent
Adult
Aged
Cerebral Infarction/etiology
Child
Coronary Disease/diagnosis
Diagnosis, Differential
Female
Heart Valve Diseases/diagnosis
Humans
Male
Middle Aged
LA - fre
N1 - Fillette, F
Ducardonnet, A
Lebrun, S
Fontaine, G
Grosgogeat, Y
English Abstract
Journal Article
France
Arch Mal Coeur Vaiss. 1983 Jun;76(6):687-94.
OP - Analyse rétrospective d'une série de 330 enregistrements de Holter. Valeur
diagnostique de la méthode et corrélation avec la symptomatologie.
PY - 1983
SN - 0003-9683 (Print)
0003-9683
SP - 687-94
ST - [Retrospective analysis of a series of 330 Holter recordings. Diagnostic
value of the method and correlation with symptomology]
TI - [Retrospective analysis of a series of 330 Holter recordings. Diagnostic
value of the method and correlation with symptomology]
VL - 76
ID - 2747
ER -
TY - JOUR
AN - 17363428
AU - Finsterer, J.
AU - Stollberger, C.
DA - May
DP - NLM
ET - 2007/03/17
IS - 5
KW - Atherosclerosis/genetics/physiopathology
Atrial Fibrillation/genetics/physiopathology
Cardiac Output, Low/genetics/physiopathology
Cardiomyopathy, Restrictive/*complications/genetics/physiopathology
Humans
Stroke/*etiology
Ventricular Dysfunction, Left/*complications/*genetics/physiopathology
LA - eng
N1 - Finsterer, Josef
Stollberger, Claudia
Comment
Letter
England
Europace. 2007 May;9(5):333. doi: 10.1093/europace/eum012. Epub 2007 Mar 15.
PY - 2007
SN - 1099-5129 (Print)
1099-5129
SP - 333
ST - Genetic background of left ventricular hypertrabeculation/non-compaction with
stroke
T2 - Europace
TI - Genetic background of left ventricular hypertrabeculation/non-compaction with
stroke
VL - 9
ID - 2768
ER -
TY - JOUR
AN - 18384895
AU - Finsterer, J.
AU - Stöllberger, C.
DA - May 15
DO - 10.1016/j.ijcard.2007.12.085
DP - NLM
ET - 2008/04/04
IS - 2
KW - Aged
Atrial Flutter/*complications
Female
Humans
Hypertrophy, Left Ventricular/*complications/*diagnostic imaging
Stroke/*etiology
LA - eng
N1 - 1874-1754
Finsterer, Josef
Stöllberger, Claudia
Case Reports
Letter
Netherlands
Int J Cardiol. 2009 May 15;134(2):e56-8. doi: 10.1016/j.ijcard.2007.12.085. Epub
2008 Apr 1.
PY - 2009
SN - 0167-5273
SP - e56-8
ST - Stroke from paroxysmal atrial flutter or left ventricular
hypertrabeculation/noncompaction, visible only on transesophageal echocardiography
T2 - Int J Cardiol
TI - Stroke from paroxysmal atrial flutter or left ventricular
hypertrabeculation/noncompaction, visible only on transesophageal echocardiography
VL - 134
ID - 2765
ER -
TY - JOUR
AB - The risk of embolic stroke during sick sinus syndrome before cardiac
pacemaker insertion is substantial, but stroke after pacemaker insertion has not
been well studied. We observed 10 sick sinus syndrome patients who developed an
ischemic stroke 4 days to 112 months after pacemaker insertion. Nine patients
represented 6% of the 156 ischemic stroke patients observed during a 30-month
period. Eight had a ventricular-demand pacemaker, one had a dual-chamber pacemaker,
and one had an atrial-inhibited pacemaker. Six patients were in atrial fibrillation
at stroke onset, but none had atrial fibrillation when the pacemaker was inserted.
Six patients were taking aspirin, and one was anticoagulated when stroke occurred.
Stroke in sick sinus syndrome after pacemaker insertion is not rare, and pacing
does not appear to be protective. Sick sinus syndrome patients who convert to
atrial fibrillation or who have a ventricular-demand pacemaker might represent
high-risk groups for stroke.
AD - Department of Neurology, Worcester Memorial Hospital, MA 01605.
AN - 3376162
AU - Fisher, M.
AU - Kase, C. S.
AU - Stelle, B.
AU - Mills, R. M., Jr.
DA - Jun
DO - 10.1161/01.str.19.6.712
DP - NLM
ET - 1988/06/01
IS - 6
J2 - Stroke
KW - Aged
Aged, 80 and over
*Cardiac Pacing, Artificial
Cerebrovascular Disorders/*etiology
Female
Humans
Male
Risk Factors
Sick Sinus Syndrome/*therapy
LA - eng
N1 - Fisher, M
Kase, C S
Stelle, B
Mills, R M Jr
Case Reports
Journal Article
United States
Stroke. 1988 Jun;19(6):712-5. doi: 10.1161/01.str.19.6.712.
PY - 1988
SN - 0039-2499 (Print)
0039-2499
SP - 712-5
ST - Ischemic stroke after cardiac pacemaker implantation in sick sinus syndrome
T2 - Stroke
TI - Ischemic stroke after cardiac pacemaker implantation in sick sinus syndrome
VL - 19
ID - 2583
ER -
TY - JOUR
AB - OBJECTIVES: This study sought to examine the association between baseline
beta-blocker (BB) dose and outcomes in the HF-ACTION (Heart Failure: A Controlled
Trial Investigating Outcomes of Exercise Training) trial. BACKGROUND: Beta-blockers
reduce morbidity and mortality in chronic heart failure (HF) patients with reduced
ejection fraction, but it is unclear whether titrating to higher BB doses improves
outcomes in this setting. METHODS: The HF-ACTION trial was a randomized,
multicenter trial enrolling 2,331 ambulatory HF patients with systolic dysfunction
(New York Heart Association functional class II to IV, left ventricular ejection
fraction <0.35) randomized to exercise training versus usual care, with median
follow-up of 2.5 years. The BB dose at baseline was standardized with carvedilol
equivalents and analyzed as a continuous variable and by discrete dose groups. The
relationship between BB dose and the primary endpoint of all-cause mortality or
all-cause hospitalization and other cardiovascular secondary endpoints was
determined before and after adjustment for variables significantly associated with
outcomes in the HF-ACTION cohort. RESULTS: Ninety-five percent of patients were
receiving a BB. There was a significant inverse relationship between BB dose and
all-cause death or hospitalization but not other cardiovascular endpoints after
adjustment for other predictors of outcome, with a linear benefit up to the 50-mg
daily dose. There was a significant association between BB dose and change in peak
VO(2) at 3 months. There was no increase in bradycardia with higher doses of BB.
CONCLUSIONS: There was a significant inverse relationship between BB dose and the
endpoint of all-cause death or all-cause hospitalization in this well-treated HF
cohort with systolic dysfunction, supporting recommendations that titrating doses
up to 50 mg/day might confer a benefit in such patients. (Exercise Training Program
to Improve Clinical Outcomes in Individuals With Congestive Heart Failure;
NCT00047437).
AD - Duke University and the Duke Clinical Research Institute, Durham, North
Carolina 27710, USA. mona.fiuzat@duke.edu
AN - 22560018
AU - Fiuzat, M.
AU - Wojdyla, D.
AU - Kitzman, D.
AU - Fleg, J.
AU - Keteyian, S. J.
AU - Kraus, W. E.
AU - Piña, I. L.
AU - Whellan, D.
AU - O'Connor, C. M.
C2 - PMC3396733
C6 - NIHMS371679
DA - Jul 17
DO - 10.1016/j.jacc.2012.03.023
DP - NLM
ET - 2012/05/09
IS - 3
KW - Adrenergic beta-Antagonists/*administration & dosage/adverse effects
Bradycardia/chemically induced
*Exercise
Female
Heart Failure, Systolic/complications/*drug therapy/mortality
Humans
Male
Middle Aged
Myocardial Infarction/epidemiology/prevention & control
LA - eng
N1 - 1558-3597
Fiuzat, Mona
Wojdyla, Daniel
Kitzman, Dalane
Fleg, Jerome
Keteyian, Steven J
Kraus, William E
Piña, Ileana L
Whellan, David
O'Connor, Christopher M
U01 HL063747-06S1/HL/NHLBI NIH HHS/United States
Journal Article
Multicenter Study
J Am Coll Cardiol. 2012 Jul 17;60(3):208-15. doi: 10.1016/j.jacc.2012.03.023. Epub
2012 May 2.
PY - 2012
SN - 0735-1097 (Print)
0735-1097
SP - 208-15
ST - Relationship of beta-blocker dose with outcomes in ambulatory heart failure
patients with systolic dysfunction: results from the HF-ACTION (Heart Failure: A
Controlled Trial Investigating Outcomes of Exercise Training) trial
TI - Relationship of beta-blocker dose with outcomes in ambulatory heart failure
patients with systolic dysfunction: results from the HF-ACTION (Heart Failure: A
Controlled Trial Investigating Outcomes of Exercise Training) trial
VL - 60
ID - 2669
ER -
TY - JOUR
AB - BACKGROUND: Atrial fibrillation (AF) may occur without symptoms. Little is
known about demographic features and prognostic information in patients with
asymptomatic AF. METHODS: In the AFFIRM study, 4060 patients were randomized to
either rhythm or rate control. At baseline, patients were identified as
asymptomatic if they answered "no" to a 15-item questionnaire related to cardiac
symptoms during AF in the 6 months before study entry. RESULTS: There were 481
(12%) asymptomatic patients at baseline. Compared with symptomatic patients,
asymptomatic patients were more often men and had a lower incidence of coronary
artery disease and congestive heart failure, but had more cerebrovascular events.
Asymptomatic patients had a longer duration of AF, a lower maximum heart rate, and
better left ventricular function. They received fewer cardiac medications and fewer
therapies to maintain sinus rhythm. At 5 years, there was a trend for better
survival in asymptomatic patients (81% vs 77%, P = .058), and they were more likely
to be free from disabling stroke or anoxic encephalopathy, major bleeding, and
cardiac arrest (79% vs 67%, P = .024). However, mortality and major events were
similar after correction for baseline differences. CONCLUSIONS: Patients with
asymptomatic AF have less serious heart disease but more cerebrovascular disease.
Asymptomatic patients receive different therapies than symptomatic patients.
However, the absence of symptoms and the differences in treatment does not confer a
more favorable prognosis when differences in baseline clinical parameters are
considered. Anticoagulation should be considered in these patients.
AD - University of Missouri-Columbia School of Medicine, Columbia, Mo 65212, USA.
flakerg@health.missouri.edu
AN - 15990749
AU - Flaker, G. C.
AU - Belew, K.
AU - Beckman, K.
AU - Vidaillet, H.
AU - Kron, J.
AU - Safford, R.
AU - Mickel, M.
AU - Barrell, P.
DA - Apr
DO - 10.1016/j.ahj.2004.06.032
DP - NLM
ET - 2005/07/02
IS - 4
KW - Aged
Anti-Arrhythmia Agents/administration & dosage/therapeutic use
Anticoagulants/administration & dosage/adverse effects/therapeutic use
Atrial Fibrillation/drug therapy/*epidemiology/surgery/therapy
Cause of Death
Comorbidity
Coronary Disease/epidemiology
Female
Follow-Up Studies
Hemorrhage/chemically induced/epidemiology
Humans
Incidence
Male
Middle Aged
Prognosis
Quality of Life
Socioeconomic Factors
Survival Analysis
Treatment Outcome
Ventricular Dysfunction, Left/epidemiology
LA - eng
N1 - 1097-6744
Flaker, Greg C
Belew, Kathy
Beckman, Karen
Vidaillet, Humberto
Kron, Jack
Safford, Robert
Mickel, Mary
Barrell, Patrick
AFFIRM Investigators
Comparative Study
Journal Article
Multicenter Study
United States
Am Heart J. 2005 Apr;149(4):657-63. doi: 10.1016/j.ahj.2004.06.032.
PY - 2005
SN - 0002-8703
SP - 657-63
ST - Asymptomatic atrial fibrillation: demographic features and prognostic
information from the Atrial Fibrillation Follow-up Investigation of Rhythm
Management (AFFIRM) study
T2 - Am Heart J
TI - Asymptomatic atrial fibrillation: demographic features and prognostic
information from the Atrial Fibrillation Follow-up Investigation of Rhythm
Management (AFFIRM) study
VL - 149
ID - 2988
ER -
TY - JOUR
AB - BACKGROUND: Aspirin is used in combination with anticoagulant therapy in
patients with atrial fibrillation (AF), but evidence of additional efficacy is not
available. METHODS: We compared ischemic events and bleeding in the SPORTIF III and
IV randomized trials of anticoagulation with warfarin (international normalized
ratio 2-3) or fixed-dose ximelagatran. Low-dose aspirin (<100 mg/d) was allowed
based on prevailing guidelines. RESULTS: The 14% of patients receiving aspirin more
often had diabetes (27.5% vs 23%, P < .01), coronary artery disease (69% vs 41%, P
< .01), previous stroke or transient ischemic attack (26% vs 20%, P < .01), and
left ventricular dysfunction (41% vs 36%, P < .01). Addition of aspirin to either
warfarin or ximelagatran was associated with no reduction in stroke or systemic
embolism. Major bleeding occurred significantly more often with aspirin plus
warfarin (3.9% per year) than with warfarin alone (2.3% per year, P < .01), aspirin
plus ximelagatran (2.0% per year), or ximelagatran alone (1.9% per year). The rate
of myocardial infarction with aspirin and warfarin (0.6% per year) was not
significantly different from that with ximelagatran alone (1.0% per year), warfarin
alone (1.0% per year), or aspirin and ximelagatran (1.4% per year). CONCLUSIONS:
Aspirin combined with anticoagulant therapy was associated with no reduction in
stroke, systemic embolism, or myocardial infarction in patients with AF. Aspirin
combined with warfarin was associated with an incremental rate of major bleeding of
1.6% per year. No increased major bleeding occurred with aspirin and ximelagatran.
These results suggest that the risks associated with addition of aspirin to
anticoagulation in patients with AF outweigh the benefit.
AD - Department of Medicine, University of Missouri-Columbia, Columbia, MO, USA.
AN - 17070169
AU - Flaker, G. C.
AU - Gruber, M.
AU - Goldman, S.
AU - Chaparro, S.
AU - Vahanian, A.
AU - Halinen, M. O.
AU - Horrow, J.
DA - Nov
DO - 10.1016/j.ahj.2006.06.024
DP - NLM
ET - 2006/10/31
IS - 5
KW - Aged
Anticoagulants/adverse effects/*therapeutic use
Aspirin/adverse effects/*therapeutic use
Azetidines/adverse effects/therapeutic use
Benzylamines/adverse effects/therapeutic use
Embolism/prevention & control
Female
Humans
Male
Middle Aged
Myocardial Ischemia/prevention & control
Platelet Aggregation Inhibitors/adverse effects/*therapeutic use
Risk Assessment
Treatment Outcome
Warfarin/adverse effects/therapeutic use
LA - eng
N1 - 1097-6744
Flaker, Greg C
Gruber, Michael
Connolly, Stuart J
Goldman, Steven
Chaparro, Sandra
Vahanian, Alec
Halinen, Matti O
Horrow, Jay
SPORTIF Investigators
Journal Article
United States
Am Heart J. 2006 Nov;152(5):967-73. doi: 10.1016/j.ahj.2006.06.024.
PY - 2006
SN - 0002-8703
SP - 967-73
ST - Risks and benefits of combining aspirin with anticoagulant therapy in
patients with atrial fibrillation: an exploratory analysis of stroke prevention
using an oral thrombin inhibitor in atrial fibrillation (SPORTIF) trials
T2 - Am Heart J
TI - Risks and benefits of combining aspirin with anticoagulant therapy in
patients with atrial fibrillation: an exploratory analysis of stroke prevention
using an oral thrombin inhibitor in atrial fibrillation (SPORTIF) trials
VL - 152
ID - 2951
ER -
TY - JOUR
AB - Cardiac arrhythmias are an important cause of neurologic symptoms.
Bradyarrhythmias and tachyarrhythmias, by disrupting blood flow to the brain and
causing cerebral hypoxia, can lead to loss of consciousness (and ultimately to
cerebral necrosis or death). Thus cardiac arrhythmias must be considered as a
potential cause in any patient presenting with syncope. For syncopal patients in
whom the substrate for reentrant ventricular arrhythmias is found (that is,
patients with ventricular dysfunction), management must be extremely aggressive
because their near-term risk for sudden death is high, and conservative therapy is
ineffective. Embolic stroke is a common result of atrial fibrillation. Several
randomized trials now indicate that anticoagulation with low-dose warfarin is
necessary, whenever possible, in patients with atrial fibrillation even in the
absence of underlying valvular heart disease. Ongoing studies are evaluating the
efficacy of aspirin in preventing embolic events.
AD - Department of Medicine, Medical College of Pennsylvania, Pittsburgh.
AN - 8316191
AU - Fogoros, R. N.
DA - May
DP - NLM
ET - 1993/05/01
IS - 2
J2 - Neurologic clinics
KW - Arrhythmias, Cardiac/complications/*diagnosis/physiopathology
Brain/blood supply/physiopathology
Brain Diseases/complications/diagnosis/physiopathology
Cerebrovascular Disorders/diagnosis/etiology
Electrocardiography
Female
Heart Ventricles/physiopathology
Humans
Male
Syncope/*diagnosis/etiology
LA - eng
N1 - Fogoros, R N
Journal Article
Review
United States
Neurol Clin. 1993 May;11(2):375-90.
PY - 1993
SN - 0733-8619 (Print)
0733-8619
SP - 375-90
ST - Cardiac arrhythmias. Syncope and stroke
T2 - Neurol Clin
TI - Cardiac arrhythmias. Syncope and stroke
VL - 11
ID - 2326
ER -
TY - JOUR
AB - Atrial fibrillation is increasingly common with advancing age and is
responsible for 10% of the half-million strokes that occur annually in the United
States. When a patient presents with atrial fibrillation, the physician's first
task is to use the history, physical examination, and electrocardiogram to
determine whether hospitalization is necessary. Factors indicating a need for
hospital care include evidence of infarction or ischemia, congestive heart failure,
hypotension or hypoperfusion, excessive rate, or pre-excitation. In addition, if
the episode began within 48 hours, consider early cardioversion, which also
requires hospitalization. Next, the need for control of the ventricular rate should
be assessed. A heart rate under 90 beats/min at rest and under 120 beats/min after
1 minute of step exercise is a reasonable goal. Dixogin usually controls the
resting rate, but sometimes beta-blockers or calcium channel blockers are needed to
control the exercise rate. The need for anticoagulation is determined by the
presence of clinical risk factors such as valvular heart disease, previous
thromboembolism, hypertension, age over 65 years, congestive heart failure, and
left atrial enlargement. An echocardiogram is necessary to complete this
assessment. Patients having one or more of these risk factors are most effectively
treated with warfarin, as evident from several clinical trials. Although patients
over age 65 demonstrate reduced thromboembolism with warfarin therapy, they also
are more prone to cerebral hemorrhage, thus, their international normalization
ratio (INR) should be kept at the lower end of the therapeutic range [2,3]. Other
patients can be treated with aspirin, although stroke reduction in these patients
may be more related to reduction of arterial thrombosis than thromboembolism.
Patients under age 65 with no risk factors have a very low annual risk of stroke
without therapy (approximately 1%). If symptoms persist or if this is a first
episode in someone without left atrial enlargement, cardioversion can be considered
after 3 weeks of warfarin therapy with INR in the therapeutic range. Otherwise,
warfarin should be continued indefinitely. Prevention of recurrence with
antiarrhythmic drugs is somewhat problematic because of incomplete efficacy (30%
recurrence at 1 year) and the potential for inducing other, life-threatening
arrhythmias.
AD - Department of Medicine, University of Massachusetts Medical School,
Worcester, Massachusetts, USA.
AN - 10364778
AU - Folland, E. D.
DA - Apr
DO - 10.1023/a:1008877302411
DP - NLM
ET - 1999/06/12
IS - 2
J2 - Journal of thrombosis and thrombolysis
KW - Aged
Aged, 80 and over
Atrial Fibrillation/complications/epidemiology/*therapy
Heart Rate
Hospitalization
Humans
Middle Aged
*Outpatients
Quality Assurance, Health Care
Recurrence
Risk Factors
LA - eng
N1 - Folland, E D
Journal Article
Review
Netherlands
J Thromb Thrombolysis. 1999 Apr;7(2):131-5. doi: 10.1023/a:1008877302411.
PY - 1999
SN - 0929-5305 (Print)
0929-5305
SP - 131-5
ST - Management of atrial fibrillation: out-of-hospital approach
T2 - J Thromb Thrombolysis
TI - Management of atrial fibrillation: out-of-hospital approach
VL - 7
ID - 2894
ER -
TY - JOUR
AB - 330 patients with ischemic stroke entered the trial. They were divided into
two groups: 72 (21.8%) patients with hemodynamic stroke (group 1) and the rest 258
(78.2%) patients with other pathogenetic subtypes of stroke (group 2). Heart rhythm
and myocardial ischemia were studied using ECG and Holter monitoring.
Electrocardiographically, hemodynamic stroke is characterized by frequent
ventricular extrasystole, sick sinus syndrome and transient atrioventricular block
of the second and third degree with pauses 2 s and longer, ventricular fibrillation
and painless myocardial ischemia. Perpetual and paroxysmal atrial fibrillation and
paroxysmal ventricular tachycardia are not pathognomonic for hemodynamic stroke
though these disorders can be also considered as independent pathogenetic factors
of hemodynamic cerebral focal lesion.
AN - 12471831
AU - Foniakin, A. V.
AU - Geraskina, L. A.
AU - Suslina, Z. A.
DP - NLM
ET - 2002/12/11
IS - 10
KW - Adolescent
Adult
Aged
Aged, 80 and over
Arrhythmias, Cardiac/*complications/diagnosis/*physiopathology
Cardiac Output/physiology
Female
Humans
Male
Middle Aged
Myocardial Ischemia/*complications/diagnosis/*physiopathology
Stroke/*complications/*physiopathology
Vascular Resistance
LA - rus
N1 - Foniakin, A V
Geraskina, L A
Suslina, Z A
Clinical Trial
English Abstract
Journal Article
Russia (Federation)
Klin Med (Mosk). 2002;80(10):17-20.
OP - Patogeneticheskaia otsenka narusheniĭ ritma serdtsa i ishemii miokarda pri
gemodinamicheskom insul'te.
PY - 2002
SN - 0023-2149 (Print)
0023-2149
SP - 17-20
ST - [Pathogenetic assessment of cardiac arrhythmia and myocardial ischemia in
hemodynamic stroke]
TI - [Pathogenetic assessment of cardiac arrhythmia and myocardial ischemia in
hemodynamic stroke]
VL - 80
ID - 2402
ER -
TY - JOUR
AB - BACKGROUND: During implantable cardioverter defibrillator insertion, induced
ventricular fibrillation followed by test shocks (defibrillation threshold testing
[DFT]) is utilized to confirm effective device function. The effect of DFT on
ventricular function is uncertain. Brain natriuretic peptide (BNP) is a marker of
ventricular dysfunction and hemodynamic stress. We hypothesized that DFT causes
increased BNP levels. METHODS: BNP, creatine kinase, creatine kinase-MB (CK-MB),
and troponin I (cTnI) were measured in 31 patients (mean age 71.4 years; 12 women)
at preinsertion (T1), at 2-4 hours (T2), and at 8-12 hours (T3) after DFT.
Biomarker levels were compared in patients receiving one shock (Group A) or two
shocks (Group B). RESULTS: After DFT all biomarkers increased above baseline levels
but did not reach levels diagnostic for myocardial infarction. From T1 to T2,
elevations in CK-MB and cTnI occurred in the highest proportion of patients (CK-MB
90% and cTnI 84%). From T1 to T3, elevation in BNP and cTnI were most prevalent
(BNP 83% and cTnI 90%). Significant increases were measured in BNP levels from T1
to T3 (P = 0.0003), CK-MB levels from T1 to T2 (P < 0.0001), and cTnI levels from
T1 to T2 (P < 0.0001) and from T1 to T3 (P < 0.0001). CK-MB levels did not increase
significantly from T1 to T3 (P = 0.51). CONCLUSIONS: BNP levels rise progressively
after DFT accompanied by early CK-MB increases and sustained increases in cTnI.
These data suggest that DFT is associated with hemodynamic stress and left
ventricular dysfunction, as evidenced by increases in BNP.
AD - Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
ckfrancismd2004@yahoo.com
AN - 22126159
AU - Francis, C. K.
AU - Kuo, Y. H.
AU - Azzam, I.
AU - Selim, S.
AU - Patel, N.
AU - Beri, R.
AU - Goldman, D.
AU - Girgis, I.
AU - Daniels, S.
DA - Mar
DO - 10.1111/j.1540-8159.2011.03275.x
DP - NLM
ET - 2011/12/01
IS - 3
KW - Aged
Biomarkers/*blood
Creatine Kinase, MB Form/blood
Electric Countershock/*adverse effects
Female
Humans
Male
Myocardial Ischemia/*blood/diagnosis
Tachycardia, Ventricular/blood/therapy
Troponin I/blood
Ventricular Dysfunction, Left/blood/therapy
LA - eng
N1 - 1540-8159
Francis, Charles K
Kuo, Yen-Hong
Azzam, Iyad
Selim, Samy
Patel, Nishant
Beri, Rohit
Goldman, Daniel
Girgis, Ihab
Daniels, Steven
Journal Article
United States
Pacing Clin Electrophysiol. 2012 Mar;35(3):314-9. doi: 10.1111/j.1540-
8159.2011.03275.x. Epub 2011 Nov 29.
PY - 2012
SN - 0147-8389
SP - 314-9
ST - Brain natriuretic peptide and biomarkers of myocardial ischemia increase
after defibrillation threshold testing
TI - Brain natriuretic peptide and biomarkers of myocardial ischemia increase
after defibrillation threshold testing
VL - 35
ID - 2983
ER -
TY - JOUR
AB - While the number of deaths from coronary artery and cerebrovascular disease
is clearly decreasing in the U.S., the prevalence of congestive heart failure (CHF)
seems to be increasing. Many studies have found that more than half of the CHF-
related deaths are sudden, and presumably are due to ventricular arrhythmias.
Knowledge of the pathophysiology of arrhythmias in the patient with CHF is limited,
but left ventricular mechanical abnormalities, diuretic-induced hypokalemia,
hypomagnesemia and inotropic therapy may play a role. The prevalence of couplets,
multiformed ventricular premature complexes or both is very high, averaging 87% in
8 different studies. The prevalence of nonsustained ventricular tachycardia,
determined by ambulatory electrocardiographic recordings, is also quite high; it is
approximately 54% in these same studies. Although still unclear, some data now
suggest that ventricular arrhythmias may independently influence prognosis in
patients with CHF. Future research is obviously necessary to evaluate the influence
of antiarrhythmic therapy on survival. However, preliminary findings appear to
indicate that treatment may not affect long-term survival in these patients.
AN - 3946204
AU - Francis, G. S.
DA - Jan 31
DO - 10.1016/0002-9149(86)90991-4
DP - NLM
ET - 1986/01/31
IS - 3
KW - Arrhythmias, Cardiac/*etiology
Electrocardiography
Heart Ventricles
Humans
Prognosis
Tachycardia/etiology
Time Factors
LA - eng
N1 - Francis, G S
HL07184/HL/NHLBI NIH HHS/United States
HL22977-03/HL/NHLBI NIH HHS/United States
Journal Article
United States
Am J Cardiol. 1986 Jan 31;57(3):3B-7B. doi: 10.1016/0002-9149(86)90991-4.
PY - 1986
SN - 0002-9149 (Print)
0002-9149
SP - 3b-7b
ST - Development of arrhythmias in the patient with congestive heart failure:
pathophysiology, prevalence and prognosis
T2 - Am J Cardiol
TI - Development of arrhythmias in the patient with congestive heart failure:
pathophysiology, prevalence and prognosis
VL - 57
ID - 2816
ER -
TY - JOUR
AB - A patient with a prolonged electrocardiographic Q-T interval suddenly
developed left hemiplegia after an episode of ventricular fibrillation. A CT scan
showed a cerebral infarction in the right internal capsule. The prolonged Q-T
interval, by virtue of its association with cardiac arrhythmias, may cause cerebral
hypoperfusion that commonly results in generalized neurological deficits. The lack
of evidence for embolization in this patient suggests that decreased cerebral
perfusion was responsible for the genesis of her neurological signs and symptoms.
The prolonged Q-T interval is an easily overlooked cardiac abnormality that must be
considered in a patient who exhibits a focal neurological deficit.
AN - 7336315
AU - Frank, E.
AU - Tew, J. M., Jr.
AU - Pagani, L.
DA - Nov
DO - 10.1016/0090-3019(81)90265-2
DP - NLM
ET - 1981/11/01
IS - 5
J2 - Surgical neurology
KW - Adult
Cerebral Infarction/diagnostic imaging/*etiology
Electrocardiography
Female
Humans
LA - eng
N1 - Frank, E
Tew, J M Jr
Pagani, L
Case Reports
Journal Article
United States
Surg Neurol. 1981 Nov;16(5):333-5. doi: 10.1016/0090-3019(81)90265-2.
PY - 1981
SN - 0090-3019 (Print)
0090-3019
SP - 333-5
ST - The prolonged Q-T syndrome presenting as a focal neurological lesion
T2 - Surg Neurol
TI - The prolonged Q-T syndrome presenting as a focal neurological lesion
VL - 16
ID - 2773
ER -
TY - JOUR
AB - We hypothesized that losartan was superior to atenolol in reducing
cardiovascular events in a lower-risk group (LRG) versus a higher-risk group (HRG)
of patients in a Losartan Intervention For Endpoint reduction (LIFE) substudy,
independently of blood pressure (BP) reduction. In a post hoc analysis, we
designated 4282 patients as LRG on the basis of: (1) no previous cardiovascular
disease (coronary, cerebral, peripheral vascular disease); (2) no diabetes; (3) no
isolated systolic hypertension; and (4) inclusion of the lowest 3 quartiles of
electrocardiographically documented left ventricular hypertrophy. The HRG consisted
of 4911 remaining patients who did not qualify for the LRG. In the LRG, losartan
was superior to atenolol in reducing stroke: hazard ratio (HR), 0.72 (95%
confidence interval [CI], 0.53 to 0.98); new-onset diabetes (HR, 0.74 [95% CI, 0.58
to 0.93]; and new-onset atrial fibrillation: HR, 0.69 (95% CI, 0.51 to 0.92), all
P<0.05 but not composite end points or cardiovascular mortality (both P=NS). In the
HRG, losartan was superior to atenolol in reducing composite end points: HR, 0.82
(95% CI, 0.71 to 0.94), P<0.01; cardiovascular mortality: HR, 0.77 (95% CI, 0.62 to
0.95), P<0.05; stroke: HR, 0.75 (95% CI, 0.61 to 0.92), P<0.01; new-onset diabetes:
HR, 0.76 (95% CI, 0.60 to 0.96), P<0.05; and new-onset atrial fibrillation: HR,
0.71 (95% CI, 0.58 to 88), P<0.05. Test for interaction of treatment with LRG
versus HRG was not significant for composite end point, stroke, or atrial
fibrillation, but was for cardiovascular mortality (P=0.018). Achieved systolic BP
reduction favored losartan over atenolol by -1.8 mm Hg in LRG (P=NS) and -0.7 mm Hg
(P=0.001) in HRG, but no significant differences occurred in diastolic or mean BP
in either group. In conclusion, losartan compared with atenolol reduces the risk of
stroke, new-onset diabetes, and new-onset atrial fibrillation in the LRG and the
HRG.
AD - Heart Disease Prevention Program, University of California, Irvine, CA 92697,
USA. ssfranklinmd@earthlink.net
AN - 16116047
AU - Franklin, S. S.
AU - Wachtell, K.
AU - Papademetriou, V.
AU - Olsen, M. H.
AU - Fyhrquist, F.
AU - Ibsen, H.
AU - Kjeldsen, S. E.
AU - Dahlöf, B.
DA - Sep
DO - 10.1161/01.HYP.0000179604.42845.8d
DP - NLM
ET - 2005/08/24
IS - 3
J2 - Hypertension (Dallas, Tex. : 1979)
Aged, 80 and over
Angiotensin II Type 1 Receptor Blockers/therapeutic use
Animals
Atenolol/*therapeutic use
Cardiovascular Diseases/*complications/*mortality
Diabetes Mellitus/prevention & control
Female
Humans
Hypertension/*complications/drug therapy/physiopathology
Losartan/*therapeutic use
Male
Middle Aged
Risk
LA - eng
N1 - 1524-4563
Franklin, Stanley S
Wachtell, Kristian
Papademetriou, Vasilios
Olsen, Michael H
Devereux, Richard B
Fyhrquist, Frej
Ibsen, Hans
Kjeldsen, Sverre E
Dahlöf, Björn
Journal Article
United States
Hypertension. 2005 Sep;46(3):492-9. doi: 10.1161/01.HYP.0000179604.42845.8d. Epub
2005 Aug 22.
PY - 2005
SN - 0194-911x
SP - 492-9
ST - Cardiovascular morbidity and mortality in hypertensive patients with lower
versus higher risk: a LIFE substudy
T2 - Hypertension
TI - Cardiovascular morbidity and mortality in hypertensive patients with lower
versus higher risk: a LIFE substudy
VL - 46
ID - 2579
ER -
TY - JOUR
AB - The frequency of cardioembolic stroke is expected to rise as the general
population ages. Much of the increase may be attributed to atrial fibrillation, the
most common cause of cardioembolic stroke and one that plays a substantial role in
aging adults. Other sources of cardioembolic stroke may include ventricular
thrombus from myocardial infarction, heart failure, structural heart defects such
as patent foramen ovale (PFO), atrial septal aneurysm, proximal aortic atheroma,
valvular heart disease, and endocarditis. Diagnostic studies, such as neuroimaging,
ECG, and echocardiography, are helpful in uncovering cardioembolic sources of
stroke. Medical therapy is predicated on the underlying mechanism. For example,
warfarin may be indicated in certain patients who have atrial fibrillation, atrial,
or ventricular thrombi, and PFO with atrial septal aneurysm and cryptogenic stroke
in select young patients to prevent stroke. Newer diagnostic technologies,
including multidetector CT and cardiac MRI, may be useful to diagnose cardiac
causes of stroke when transesophageal echocardiography is indeterminate or
cryptogenic stroke is present.
AD - Departments of Neurology and Critical Care, Mayo Clinic, Cannaday 2 East,
4500 San Pablo Road, Jacksonville, FL 32224, USA. freeman.william1@mayo.edu
AN - 19026905
AU - Freeman, W. D.
AU - Aguilar, M. I.
DA - Nov
DO - 10.1016/j.ncl.2008.07.001
DP - NLM
ET - 2008/11/26
IS - 4
J2 - Neurologic clinics
KW - Atrial Fibrillation/*complications/therapy
Embolism/*complications/therapy
Humans
Stroke/*etiology/*prevention & control
LA - eng
N1 - Freeman, William D
Aguilar, Maria I
Journal Article
Review
United States
Neurol Clin. 2008 Nov;26(4):1129-60, x-xi. doi: 10.1016/j.ncl.2008.07.001.
PY - 2008
SN - 0733-8619 (Print)
0733-8619
SP - 1129-60, x-xi
ST - Stroke prevention in atrial fibrillation and other major cardiac sources of
embolism
T2 - Neurol Clin
TI - Stroke prevention in atrial fibrillation and other major cardiac sources of
embolism
VL - 26
ID - 2363
ER -
TY - JOUR
AB - BACKGROUND: In patients with heart failure, rates of clinically apparent
stroke range from 1.3% to 3.5% per year. Little is known about the incidence and
risk factors in the absence of atrial fibrillation. In the Sudden Cardiac Death in
Heart Failure Trial (SCD-HeFT), 2521 patients with moderate heart failure were
randomized to receive amiodarone, implanted cardioverter-defibrillators (ICDs), or
placebo. METHODS AND RESULTS: We determined the incidence of stroke or peripheral
or pulmonary embolism in patients with no history of atrial fibrillation (n=2114),
predictors of thromboembolism and the relationship to left ventricular ejection
fraction. Median follow-up was 45.5 months. Kaplan-Meier estimates (95% CIs) for
the incidence of thromboembolism by 4 years were 4.0% (3.0% to 4.9%), with 2.6%
(1.1% to 4.1%) in patients randomized to amiodarone, 3.2% (1.8% to 4.7%) in
patients randomized to ICD, and 6.0% (4.0% to 8.0%) in patients randomized to
placebo (approximate rates of 0.7%, 0.8%, and 1.5% per year, respectively). By
multivariable analysis, hypertension (P=0.021) and decreasing left ventricular
ejection fraction (P=0.023) were significant predictors of thromboembolism;
treatment with amiodarone or ICD treatment was a significant predictor of
thromboembolism-free survival (P=0.014 for treatment effect; hazard ratio [95% CI]
versus placebo, 0.57 [0.33 to 0.99] for ICD; 0.44 [0.24 to 0.80] for amiodarone).
Inclusion of atrial fibrillation during follow-up in the multivariable model did
not affect the significance of treatment assignment as a predictor of
thromboembolism. CONCLUSIONS: In the SCD-HeFT patient cohort, which reflects
contemporary treatment of patients with moderately symptomatic systolic heart
failure, patients experienced thromboembolism events at a rate of 1.7% per year
without antiarrhythmic therapy. Those treated with amiodarone or ICDs had lower
risk of thromboembolism than those given placebo. Hypertension at baseline and
lower ejection fraction were independent predictors of risk.
AD - Department of Medicine, Robert Wood Johnson Medical School, Suite 6100, 125
Paterson St, New Brunswick, NJ 08903, USA. r.freudenberger@yahoo.com
AN - 17485579
AU - Freudenberger, R. S.
AU - Hellkamp, A. S.
AU - Poole, J.
AU - Anderson, J.
AU - Johnson, G.
AU - Mark, D. B.
AU - Lee, K. L.
AU - Bardy, G. H.
DA - May 22
DP - NLM
ET - 2007/05/09
IS - 20
J2 - Circulation
KW - Aged
Atrial Fibrillation
Death, Sudden, Cardiac
Female
Heart Failure/*complications/therapy
Humans
Incidence
Male
Middle Aged
Pulmonary Embolism/epidemiology/etiology
Risk Factors
LA - eng
N1 - 1524-4539
Freudenberger, Ronald S
Hellkamp, Anne S
Poole, Jeanne
Anderson, Jill
Johnson, George
Mark, Daniel B
Lee, Kerry L
Bardy, Gust H
SCD-HeFT Investigators
Journal Article
United States
Circulation. 2007 May 22;115(20):2637-41. doi: 10.1161/CIRCULATIONAHA.106.661397.
Epub 2007 May 7.
PY - 2007
SN - 0009-7322
SP - 2637-41
ST - Risk of thromboembolism in heart failure: an analysis from the Sudden Cardiac
Death in Heart Failure Trial (SCD-HeFT)
T2 - Circulation
TI - Risk of thromboembolism in heart failure: an analysis from the Sudden Cardiac
Death in Heart Failure Trial (SCD-HeFT)
VL - 115
ID - 2682
ER -
TY - JOUR
AB - BACKGROUND: Atrial fibrillation (AF) is a cardiac rhythm disturbance arising
from disorganized electrical activity in the atria, and it is accompanied by an
irregular and often rapid ventricular response. It is the most common clinically
significant dysrhythmia in the general and older population. TYPES OF STUDIES
REVIEWED: The authors conducted a MEDLINE search using the key terms "atrial
fibrillation," "epidemiology," "pathophysiology," "treatment" and "dentistry." They
selected contemporaneous articles published in peer-reviewed journals and gave
preference to articles reporting randomized controlled trials. CLINICAL
IMPLICATIONS: The anticoagulant warfarin frequently is prescribed to prevent stroke
caused by cardiogenic thromboemboli arising from stagnant blood in poorly
contracting atria. Most dental procedures and a limited number of surgical
procedures can be performed without altering warfarin dosage if the international
normalized ratio value is within the therapeutic range of 2.0 to 3.0. Certain
analgesic agents, antibiotic agents, antifungal agents and sedative hypnotics,
however, should not be prescribed without consultation with the patient's physician
because these medications may alter the patient's risk of hemorrhage and stroke.
CONCLUSIONS: AF affects nearly 2.5 million Americans, most of who are older than 60
years. Consultation with the patient's physician to discuss the planned dental
treatment often is appropriate, especially for people who frequently have comorbid
diseases such as coronary artery disease, congestive heart failure, diabetes and
thyrotoxicosis, which are treated with multiple drug regimens.
AD - VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA.
arthur.friedlander@med.va.gov
AN - 19188413
AU - Friedlander, A. H.
AU - Yoshikawa, T. T.
AU - Chang, D. S.
AU - Feliciano, Z.
AU - Scully, C.
DA - Feb
DO - 10.14219/jada.archive.2009.0130
DP - NLM
ET - 2009/02/04
IS - 2
J2 - Journal of the American Dental Association (1939)
Atrial Fibrillation/physiopathology/*therapy
Contraindications
*Dental Care for Chronically Ill
Hemorrhage/prevention & control
Humans
Oral Surgical Procedures
LA - eng
N1 - Friedlander, Arthur H
Yoshikawa, Thomas T
Chang, Donald S
Feliciano, Zenaida
Scully, Crispian
Journal Article
Review
England
J Am Dent Assoc. 2009 Feb;140(2):167-77; quiz 248. doi:
10.14219/jada.archive.2009.0130.
PY - 2009
SN - 0002-8177 (Print)
0002-8177
SP - 167-77; quiz 248
ST - Atrial fibrillation: pathogenesis, medical-surgical management and dental
implications
T2 - J Am Dent Assoc
TI - Atrial fibrillation: pathogenesis, medical-surgical management and dental
implications
VL - 140
ID - 2489
ER -
TY - JOUR
AB - We report our experiences with tachycardia-induced cardiomyopathy. Nine
patients (3-56 years old) had incessant supraventricular tachycardia and congestive
heart failure. The cardiac eco-Doppler evidenced a significant increase of cardiac
volumes and mild tricuspid and mitral regurgitation. The ejection fraction (EF) was
0.31 +/- 0.12, the end diastolic volume was 162 +/- 48 cc and the end systolic
volume, 116 +/- 54 cc. Four patients had accessory pathways, 3 atrial flutter, 1 A-
V nodal reentrant tachycardia, and 1 ectopic atrial tachycardia. Two patients had
Chagasic myocarditis. Only in one chagasic patient a decreased number of
tachycardia episodes was achieved, this patient died. The autopsy revealed
cerebellar and pulmonary emboli. In the other 8 patients the arrhythmia was well
controlled. In these, the ventricular volumes decreased, the EF increased to 0.51
+/- 0.14 (p = 0.00006), and the congestive heart failure remitted. We conclude that
incessant tachycardia produces a symptomatic dilated cardiomyopathy in patients
with and without structural heart disease. The arrhythmia control is followed by an
increase in cardiac function and a remission of heart failure symptoms.
AD - Centro de Investigaciones Cardiovasculares Dr. Abdel M. Fuenmayor P., Mérida,
Venezuela.
AN - 10365228
AU - Fuenmayor, A. J.
AU - Fuenmayor, A. M.
DA - Nov-Dec
DP - NLM
ET - 1999/06/12
IS - 6
J2 - Archivos del Instituto de Cardiologia de Mexico
KW - Adolescent
Adult
Cardiomyopathies/diagnostic imaging/*etiology
Child
Child, Preschool
Female
Humans
Male
Middle Aged
Tachycardia/*complications/diagnostic imaging
LA - spa
N1 - Fuenmayor, A J
Fuenmayor, A M
Journal Article
Mexico
Arch Inst Cardiol Mex. 1998 Nov-Dec;68(6):515-20.
OP - Taquicardiomiopatía en pacientes con y sin patología cardiaca subyacente.
Experiencia en el Centro Cardiovascular de Mérida-Venezuela.
PY - 1998
SN - 0020-3785 (Print)
SP - 515-20
ST - [Tachycardiomyopathy in patients with and without subacute cardiac pathology.
Experiences at the Cardiovascular Center of Merida, Venezuela]
T2 - Arch Inst Cardiol Mex
TI - [Tachycardiomyopathy in patients with and without subacute cardiac pathology.
Experiences at the Cardiovascular Center of Merida, Venezuela]
VL - 68
ID - 2694
ER -
TY - JOUR
AB - Objective Detecting paroxysmal atrial fibrillation in patients with ischemic
stroke presenting in sinus rhythm is difficult because such episodes are often
short, and they are also frequently asymptomatic. It is possible that the
ventricular repolarization dynamics may reflect atrial vulnerability and
cardioembolic stroke. Hence, we compared the QT-RR relation between cardioembolic
stroke and atherosclerotic stroke during sinus rhythm. Methods The subjects
comprised 62 consecutive ischemic stroke patients including 31 with cardioembolic
strokes (71.8±12.7 years, 17 men) and 31 with atherosclerotic strokes (74.8±10.8
years, 23 men). The QT and RR intervals were measured from ECG waves based on a 15-
sec averaged ECG during 24-hour Holter recording using an automatic QT analyzing
system. The QT interval dependence on the RR interval was analyzed using a linear
regression line for each subject ([QT]=A[RR]+B; where A is the slope and B is the
y-intercept). Results The mean slope of the QT-RR relation was significantly
greater in cardioembolic stroke than in atherosclerotic stroke (0.187±0.044 vs.
0.142±0.045, p<0.001). The mean QT, RR, or QTc during 24-hour Holter recordings did
not differ between them. An increased slope (≥0.14) of the QT-RR regression line
could predict cardioembolic stroke with 97% sensitivity, 55% specificity and a
positive predictive value of 64%. Conclusion The increased slope of the QT-RR
linear regression line based on 24-hour Holter ECG in patients with ischemic stroke
presenting in sinus rhythm may therefore be a simple and useful marker for
cardioembolic stroke.
AD - Shizuoka Heart Rhythm Clinic, Japan.
AN - 27746427
AU - Fujiki, A.
AU - Sakabe, M.
C2 - PMC5109557
DO - 10.2169/internalmedicine.55.6702
DP - NLM
ET - 2016/10/18
IS - 20
J2 - Internal medicine (Tokyo, Japan)
KW - Adult
Aged
Atherosclerosis/physiopathology
Atrial Fibrillation/*physiopathology
Brain Ischemia/*physiopathology
Electrocardiography, Ambulatory/methods
Female
Heart Rate
Humans
Linear Models
Male
Middle Aged
Stroke/*physiopathology
LA - eng
N1 - 1349-7235
Fujiki, Akira
Sakabe, Masao
Comparative Study
Journal Article
Intern Med. 2016;55(20):2927-2932. doi: 10.2169/internalmedicine.55.6702. Epub 2016
Oct 15.
PY - 2016
SN - 0918-2918 (Print)
0918-2918
SP - 2927-2932
ST - Differences in the Slope of the QT-RR Relation Based on 24-Hour Holter ECG
Recordings between Cardioembolic and Atherosclerotic Stroke
T2 - Intern Med
TI - Differences in the Slope of the QT-RR Relation Based on 24-Hour Holter ECG
Recordings between Cardioembolic and Atherosclerotic Stroke
VL - 55
ID - 2389
ER -
TY - JOUR
AB - OBJECTIVE: The impact of pre-existing atrial fibrillation on the long-term
outcome in patients after off-pump coronary revascularisation is not well known.
This study aims to determine the independent effects of preoperative atrial
fibrillation on the early and late outcomes of off-pump coronary artery bypass
surgery. METHODS: A total of 513 patients undergoing isolated coronary artery
bypass surgery using off-pump approach between 2000 and 2005 were studied. Twenty-
six of them (5.1%) had preoperative atrial fibrillation (15 had paroxysmal atrial
fibrillation and 11 had persistent or permanent atrial fibrillation) and the other
487 patients were in normal sinus rhythm. Early and late outcomes were compared
retrospectively between patients with preoperative atrial fibrillation and patients
in sinus rhythm. The median follow-up period for the entire study population was
3.3 + or - 2.7 years. RESULTS: The baseline characteristics of the patients with
preoperative atrial fibrillation were generally similar to those of patients in
sinus rhythm. However, the patients with atrial fibrillation had a significantly
lower left ventricular ejection fraction compared with those in sinus rhythm (50 +
or - 15 vs 56 + or - 12%, p=0.03). The mean age of the atrial fibrillation group
was almost 3 years more than that of the sinus rhythm group. Operative mortality
was similar in patients with atrial fibrillation (3.8%) and those in sinus rhythm
(1.0%). Ten patients developed cerebral infarction within 7 days after surgery,
including one patient (3.8%) from the atrial fibrillation group and nine patients
(1.8%) from the sinus rhythm group. Long-term survival was significantly decreased
in the atrial fibrillation group (5-year survival: 70 + or - 9.6% vs 87 + or -
1.8%; p=0.0018). Freedom from cerebral complications was also significantly
decreased in the atrial fibrillation group (5-year survival: 85 + or - 8.3% vs 95 +
or - 1.2%; p=0.0009), but there were no differences in cardiac death and major
cardiac adverse events. On Cox proportional hazards regression analysis,
preoperative atrial fibrillation was a significant adverse predictor for survival
(hazard ratio=3.0, 95% confidence intervals (CIs) 1.3-6.9; p=0.009) and independent
predictor of late cerebral infarction (hazard ratio=6.2, 95% CIs 2.0-19.3;
p=0.0002). CONCLUSIONS: Uncorrected preoperative atrial fibrillation is strongly
associated with poor long-term survival and increased late cerebral complications
after off-pump coronary artery bypass surgery. Concomitant atrial fibrillation
surgery should be considered to improve the long-term results of surgical
revascularisation.
AD - Department of Surgery 1, University of Toyama, 2630 Sugitani, Toyama 930-
0194, Japan. fuka@med.u-toyama.ac.jp
AN - 20304667
AU - Fukahara, K.
AU - Kotoh, K.
AU - Doi, T.
AU - Misaki, T.
AU - Sumi, S.
DA - Sep
DO - 10.1016/j.ejcts.2010.01.062
DP - NLM
ET - 2010/03/23
IS - 3
J2 - European journal of cardio-thoracic surgery : official journal of the
European Association for Cardio-thoracic Surgery
KW - Aged
Aged, 80 and over
Atrial Fibrillation/*complications/physiopathology
Cerebral Infarction/etiology
Coronary Artery Bypass, Off-Pump/*adverse effects
Female
Humans
Male
Middle Aged
Prognosis
Treatment Outcome
LA - eng
N1 - 1873-734x
Fukahara, Kazuaki
Kotoh, Keiju
Doi, Toshio
Misaki, Takuro
Sumi, Shigeki
Journal Article
Germany
Eur J Cardiothorac Surg. 2010 Sep;38(3):366-72. doi: 10.1016/j.ejcts.2010.01.062.
Epub 2010 Mar 20.
PY - 2010
SN - 1010-7940
SP - 366-72
ST - Impact of preoperative atrial fibrillation on the late outcome of off-pump
coronary artery bypass surgery
T2 - Eur J Cardiothorac Surg
TI - Impact of preoperative atrial fibrillation on the late outcome of off-pump
coronary artery bypass surgery
VL - 38
ID - 2670
ER -
TY - JOUR
AB - The case of a 76-year-old diabetic patient with known aortic valve sclerosis
is reported. One week after implantation of a permanent pacemaker system
(indication: 2nd degree AV-block type Mobitz) he developed fever. Large
endocarditic vegetations were found on the aortic and mitral valve (blood cultures:
were positive for Staphylococcus aureus). Also from the pacemaker bed
Staphylococcus aureus was isolated and an antibiotic treatment including vancomycin
was started. Nevertheless the patient developed insufficiencies of both the aortic
and mitral valves and became hemodynamically unstable. Due to cerebral embolisms
and further deterioration of the patient's overall clinical state the already
planned operative replacement of the aortic and mitral valve could not be
performed. The patient died because of left ventricular failure after pacemaker
infection which was complicated by endocarditis.
AD - Abteilung Innere Medizin-Kardiologie, Philipps-Universität Marburg.
AN - 7927124
AU - Funck, R.
AU - Herzum, M.
AU - Barth, P. J.
AU - Bethge, C.
AU - Maisch, B.
DA - Jun
DP - NLM
ET - 1994/06/01
IS - 3
J2 - Herz
KW - Aged
Aortic Valve/pathology
Aortic Valve Insufficiency/diagnosis/*etiology/pathology
Endocarditis, Bacterial/diagnosis/*etiology/pathology
Fatal Outcome
Heart Block/pathology/*therapy
Humans
Male
Mitral Valve/pathology
Mitral Valve Insufficiency/diagnosis/*etiology/pathology
Prosthesis-Related Infections/diagnosis/*etiology/pathology
Staphylococcal Infections/diagnosis/*etiology/pathology
LA - ger
N1 - Funck, R
Herzum, M
Barth, P J
Bethge, C
Maisch, B
Case Reports
English Abstract
Journal Article
Germany
Herz. 1994 Jun;19(3):149-51.
OP - Aorten- und Mitralklappenendokarditis nach Schrittmachertascheninfektion.
PY - 1994
SN - 0340-9937 (Print)
0340-9937
SP - 149-51
ST - [Aortic and mitral valve endocarditis after infection of the pacemaker
pocket]
T2 - Herz
TI - [Aortic and mitral valve endocarditis after infection of the pacemaker
pocket]
VL - 19
ID - 2998
ER -
TY - JOUR
AB - The peri-infarct cortex (PIC) is the site of long-term physiologic changes
after ischemic stroke. Traditional methods for delineating the peri-infarct gray
matter (GM) have used a volumetric Euclidean distance metric to define its extent
around the infarct. This metric has limitations in the case of cortical stroke,
i.e., those where ischemia leads to infarction in the cortical GM, because the
vascularization of the cerebral cortex follows the complex, folded topology of the
cortical surface. Instead, we used a geodesic distance metric along the cortical
surface to subdivide the PIC into equidistant rings emanating from the infarct
border and compared this new approach to a Euclidean distance metric definition.
This was done in 11 patients with [F-18]-Flumazenil ([18-F]-FMZ) positron emission
tomography (PET) scans at 2 weeks post-stroke and at 6 month follow-up. FMZ is a
PET radiotracer with specific binding to the alpha subunits of the type A γ-
aminobutyric acid (GABAA) receptor. Additionally, we used partial-volume correction
(PVC) of the PET images to compensate for potential cortical thinning and long-term
neuronal loss in follow-up images. The difference in non-displaceable binding
potential (BP(ND) ) between the stroke unaffected and affected hemispheres was 35%
larger in the geodesic versus the Euclidean peri-infarct models in initial PET
images and 48% larger in follow-up PET images. The inter-hemispheric BP(ND)
difference was approximately 17-20% larger after PVC when compared to uncorrected
PET images. PET studies of peri-infarct GM in cortical strokes should use a
geodesic model and include PVC as a preprocessing step. Hum Brain Mapp 38:326-338,
2017. © 2016 Wiley Periodicals, Inc.
AD - Montreal Neurological Institute, McGill University, Montreal, Canada.
Jewish General Hospital, Lady Davis Institute, Montreal, Canada.
Department of Neurology, Technische Universität München, Munich, Germany.
AN - 27614005
AU - Funck, T.
AU - Al-Kuwaiti, M.
AU - Lepage, C.
AU - Zepper, P.
AU - Minuk, J.
AU - Schipper, H. M.
AU - Evans, A. C.
AU - Thiel, A.
C2 - PMC6866936
DA - Jan
DO - 10.1002/hbm.23363
DP - NLM
ET - 2016/09/11
IS - 1
J2 - Human brain mapping
KW - Aged
Aged, 80 and over
Brain Infarction/diagnostic imaging/*etiology/*pathology
Cerebral Cortex/*diagnostic imaging
Female
Humans
Image Processing, Computer-Assisted
Male
Middle Aged
Nervous System Diseases/etiology/*pathology
Neurons/*pathology
*Positron-Emission Tomography
*pet
*ischemic stroke
*neuronal density
*partial-volume effects
*receptor mapping
LA - eng
N1 - 1097-0193
Funck, Thomas
Al-Kuwaiti, Mohammed
Lepage, Claude
Zepper, Peter
Minuk, Jeffrey
Schipper, Hyman M
Evans, Alan C
Thiel, Alexander
MOP-115107/CIHR/Canada
Journal Article
Hum Brain Mapp. 2017 Jan;38(1):326-338. doi: 10.1002/hbm.23363. Epub 2016 Sep 10.
PY - 2017
SN - 1065-9471 (Print)
1065-9471
SP - 326-338
ST - Assessing neuronal density in peri-infarct cortex with PET: Effects of
cortical topology and partial volume correction
T2 - Hum Brain Mapp
TI - Assessing neuronal density in peri-infarct cortex with PET: Effects of
cortical topology and partial volume correction
VL - 38
ID - 2480
ER -
TY - JOUR
AB - In North America, atrial fibrillation is associated with at least 75 000
ischemic strokes each year. Most of these strokes occur in patients older than 75
years of age. The high incidence of stroke in very elderly persons reflects the
increasing prevalence of atrial fibrillation that occurs with advanced age, the
high incidence of stroke in elderly patients, and the failure of physicians to
prescribe antithrombotic therapy in most of these patients. This failure is related
to the increased risk for major hemorrhage with advanced age, obfuscating the
decision to institute stroke prophylaxis with antithrombotic therapy. This case-
based review describes the risk and benefits of prescribing antithrombotic therapy
for a hypothetical 80-year-old man who has atrial fibrillation and hypertension,
and it offers practical advice on managing warfarin therapy. After concluding that
the benefits of warfarin outweigh its risks in this patient, we describe how to
initiate warfarin therapy cautiously and how to monitor and dose the drug. We then
review five recent randomized, controlled trials that document the increased risk
for stroke when an international normalized ratio (INR) of less than 2.0 is
targeted among patients with atrial fibrillation. Next, we make the case that
cardioversion is not needed for this asymptomatic patient with chronic atrial
fibrillation. Instead, we choose to leave the patient in atrial fibrillation and to
control his ventricular rate with atenolol. Later, when the INR increases to 4.9,
we advocate withholding one dose of warfarin and repeating the INR test. Finally,
when the patient develops dental pain, we review the analgesic agents that are safe
to take with warfarin and explain why warfarin therapy does not have to be
interrupted during a subsequent dental extraction.
AD - Division of General Medical Science, Washington University School of
Medicine, Campus Box 8005, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
bgage@im.wustl.edu
AN - 11255522
AU - Gage, B. F.
AU - Fihn, S. D.
AU - White, R. H.
DA - Mar 20
DO - 10.7326/0003-4819-134-6-200103200-00011
DP - NLM
ET - 2001/03/20
IS - 6
KW - Aged
Aged, 80 and over
Analgesics/administration & dosage
Anticoagulants/administration & dosage/*therapeutic use
Atenolol/therapeutic use
Dental Care
Drug Monitoring
Humans
Risk Factors
Surgical Procedures, Operative
LA - eng
N1 - Gage, B F
Fihn, S D
White, R H
R01 HS10133/HS/AHRQ HHS/United States
Case Reports
Journal Article
Review
United States
Ann Intern Med. 2001 Mar 20;134(6):465-74. doi: 10.7326/0003-4819-134-6-200103200-
00011.
PY - 2001
SN - 0003-4819 (Print)
0003-4819
SP - 465-74
ST - Warfarin therapy for an octogenarian who has atrial fibrillation
T2 - Ann Intern Med
TI - Warfarin therapy for an octogenarian who has atrial fibrillation
VL - 134
ID - 2596
ER -
TY - JOUR
AB - Cardiac fibrosis and inflammation play critical roles in ventricular
remodelling after myocardial infarction (MI). Urolithin B (UB), a metabolite of
ellagitannin-rich foods, has various biological activities, but its effect on
ventricular remodelling after MI has not been determined. The present study
evaluated whether UB inhibited ventricular structural remodelling and decreased the
occurrence of ventricular arrhythmias after MI. Sprague-Dawley (SD) rats underwent
ligation of the left anterior descending coronary artery before randomization to
receive phosphate-buffered saline (PBS) or UB at doses of 2.5 mg/kg/day and
5 mg/kg/day via intraperitoneal administration or sham ligation. Cardiac function
was assessed using echocardiography, haemodynamic detection and brain natriuretic
peptide (BNP) levels 2 weeks post-MI. Hearts were used for electrophysiological
testing and molecular and histological analyses. UB (5 mg/kg/day) significantly
protected against post-MI cardiac dysfunction. UB markedly reduced infarct areas
and myocyte size and attenuated cardiac fibrosis and inflammation post-MI. UB
decreased the incidence of ventricular tachycardia and ventricular fibrillation
compared to the MI group. We determined that UB inhibited the phosphorylation of
JAK2/STAT3 and Smad2/3 signalling molecules. Our data suggest that UB reduces the
occurrence of malignant ventricular arrhythmias after MI, which is likely
associated with attenuation of ventricular structural remodelling via inactivation
of the JAK2/STAT3 and Smad2/3 signalling pathway.
AD - Department of Cardiology, The First Hospital of Nanchang, The Third
Affiliated Hospital of Nanchang University. Xiangshan North Road 128, Nanchang,
330008, Jiangxi, China.
Department of Cardiology, The First Hospital of Nanchang, The Third Affiliated
Hospital of Nanchang University. Xiangshan North Road 128, Nanchang, 330008,
Jiangxi, China. Electronic address: valansh@163.com.
AN - 31958459
AU - Gao, H.
AU - Huang, X.
AU - Tong, Y.
AU - Jiang, X.
DA - Mar 15
DO - 10.1016/j.ejphar.2020.172936
DP - NLM
ET - 2020/01/21
J2 - European journal of pharmacology
KW - Cardiac function
Myocardial infarction
Urolithin B
Ventricular arrhythmia
interest.
LA - eng
N1 - 1879-0712
Gao, Hong
Huang, Xin
Tong, Yifan
Jiang, Xiaojie
Journal Article
Netherlands
Eur J Pharmacol. 2020 Mar 15;871:172936. doi: 10.1016/j.ejphar.2020.172936. Epub
2020 Jan 17.
PY - 2020
SN - 0014-2999
SP - 172936
ST - Urolithin B improves cardiac function and reduces susceptibility to
ventricular arrhythmias in rats after myocardial infarction
T2 - Eur J Pharmacol
TI - Urolithin B improves cardiac function and reduces susceptibility to
ventricular arrhythmias in rats after myocardial infarction
VL - 871
ID - 3081
ER -
TY - JOUR
AB - BACKGROUND: Hypertrophic cardiomyopathy (HCM) is characterized by
cardiomyocyte hypertrophy and fibrosis. Although is an autosomal dominant trait, a
group of nonsarcomeric genes have been postulated as modifiers of the phenotypic
heterogeneity. MATERIAL AND METHODS: We prospectively recruited 168 HCM patients
and 136 healthy controls from three referral centres. Patients and controls were
clinically stable at entry in the study. Nine polymorphisms previously associated
with ventricular remodelling were determined: I/D ACE, AGTR1(A1666C),
CYP11B2(C344T), PGC1-α(G482S), COLIA1(G2046T), ADRB1(R389G), NOS3(G894T), RETN(-
420C>G) and CALM3(-34T>A). Their potential influence on prognosis, assessed by
hospital admissions, and their cause were recorded. RESULTS: The median follow-up
time was 49·5 months. Allele and genotype frequencies did not differ between
patients and controls. Thirty-six patients (21·5%) required urgent hospitalization
(18·5% for heart failure, 22·2% for atrial arrhythmias, 11·1% for ventricular
arrhythmias, 29·6% for ischaemic heart disease, 14·8% for stroke and 3·7% for other
reasons) with a hospitalization rate of 8·75% per year. Multivariate analysis
showed an independent predictive value for noncarriers of polymorphic COL1A1 allele
[HR: 2·76(1·26-6·05), P = 0·011] and a trend in homozygous carriers of ADRB1 Arg389
variant [HR: 1·98(0·99-4·02); P = 0·057]. CONCLUSION: Our study suggests that
COL1A1 polymorphism (2046G>T) is an independent predictor of prognosis in HCM
patients supporting the importance of nonsarcomeric genes on clinical prognosis in
HCM.
AD - Department of Cardiology, Hospital General Universitario de Elche, Alicante,
Spain.
Department of Cardiology, Hospital Clínico Universitario Virgen de la Arrixaca,
University of Murcia, IMIB-Arrixaca, Murcia, Spain.
Department of Cardiology, Hospital General Universitario, de Alicante, Alicante,
Spain.
Departament of Molecular Biology, Centro Inmunológico de Alicante, Alicante, Spain.
Department of Internal Medicine, Faculty of Medicine, University of Alcalá, Madrid,
Spain.
AN - 26608562
AU - García-Honrubia, A.
AU - Hernández-Romero, D.
AU - Orenes-Piñero, E.
AU - Romero-Aniorte, A. I.
AU - Climent, V.
AU - García, M.
AU - Garrigos-Gómez, N.
AU - Moro, C.
AU - Valdés, M.
AU - Marín, F.
DA - Feb
DO - 10.1111/eci.12572
DP - NLM
ET - 2015/11/27
IS - 2
J2 - European journal of clinical investigation
KW - Adult
Aged
Alleles
Arrhythmias, Cardiac/complications/*genetics
Calmodulin/genetics
Cardiomyopathy, Hypertrophic/complications/*genetics/physiopathology
Collagen Type I/genetics
Cytochrome P-450 CYP11B2/genetics
Female
Genetic Predisposition to Disease
Hospitalization
Humans
Male
Middle Aged
Myocardial Ischemia/complications/*genetics
Nitric Oxide Synthase Type III/genetics
Peptidyl-Dipeptidase A/genetics
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
Phenotype
Polymorphism, Genetic
Prognosis
Prospective Studies
Receptor, Angiotensin, Type 1/genetics
Receptors, Adrenergic, beta-1/genetics
Resistin/genetics
Stroke/complications/*genetics
Transcription Factors/genetics
Ventricular Remodeling/*genetics
Hypertrophic cardiomyopathy
nonsarcomeric genes
polymorphisms
LA - eng
N1 - 1365-2362
García-Honrubia, Antonio
Hernández-Romero, Diana
Orenes-Piñero, Esteban
Romero-Aniorte, Ana Isabel
Climent, Vicente
García, Miriam
Garrigos-Gómez, Noemí
Moro, Concepción
Valdés, Mariano
Marín, Francisco
Journal Article
England
Eur J Clin Invest. 2016 Feb;46(2):123-9. doi: 10.1111/eci.12572. Epub 2015 Dec 23.
PY - 2016
SN - 0014-2972
SP - 123-9
ST - Clinical implications of nonsarcomeric gene polymorphisms in hypertrophic
cardiomyopathy
T2 - Eur J Clin Invest
TI - Clinical implications of nonsarcomeric gene polymorphisms in hypertrophic
cardiomyopathy
VL - 46
ID - 2439
ER -
TY - JOUR
AB - The American Heart Association has identified metrics of ideal cardiovascular
(CV) health known as Life's Simple 7 (LS7). We determined the prospective
relationship between the LS7 and the incident atrial fibrillation (AF) in a
biracial cohort. The REasons for Geographic And Racial Differences in Stroke
(REGARDS) study enrolled non-Hispanic black and white adults 45 years or older.
This analysis included 9,576 REGARDS participants (mean age 63 ± 8.4 years; 57%
women; 30% black) who were free of AF at baseline and completed a follow-up
examination 9.4 years later. An overall LS7 score was calculated at baseline as the
sum of the LS7 component scores and classified as inadequate (0 to 4), average (5
to 9), or optimal (10 to 14) CV health. The primary outcome was incident AF,
identified at follow-up by either electrocardiogram or a self-reported medical
history of a physician diagnosis. A total of 725 incident AF cases were detected.
Compared with the inadequate category (n = 534), participants in the optimal
category (n = 1,953) had a 32% lower odds of developing AF (odds ratio 0.68; 95%
confidence interval 0.47, 0.99) in a logistic regression model adjusted for
demographic characteristics, alcohol use, left ventricular hypertrophy, coronary
heart disease, and stroke. A 1-point higher LS7 score was associated with a 5%
lower odds of incident AF (odds ratio = 0.95; 95% confidence interval 0.91, 0.99).
In conclusion, better CV health, as defined by the LS7 score, is associated with a
reduction in development of AF.
AD - Division of Cardiology, USC Keck School of Medicine, Los Angeles, California.
Electronic address: parveeng@med.usc.edu.
Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia.
Division of Cardiology, University of Massachusetts Medical School, Worcester,
Massachusetts.
Department of Health Science, Brigham Young University, Provo, Utah.
Department of Biostatistics, University of Alabama at Birmingham, Birmingham,
Alabama.
Epidemiological Cardiology Research Center (EPICARE), Wake Forest School of
Medicine, Winston-Salem, North Carolina.
Departments of Medicine and Pathology, Cardiovascular Research Institute, Larner
College of Medicine at the University of Vermont, Burlington, Vermont.
AN - 29153246
AU - Garg, P. K.
AU - O'Neal, W. T.
AU - Ogunsua, A.
AU - Thacker, E. L.
AU - Howard, G.
AU - Soliman, E. Z.
AU - Cushman, M.
C2 - PMC6080623
C6 - NIHMS954850
DA - Jan 15
DO - 10.1016/j.amjcard.2017.09.033
DP - NLM
ET - 2017/11/21
IS - 2
KW - African Americans/statistics & numerical data
Aged
Alcohol Drinking/epidemiology
American Heart Association
Atrial Fibrillation/*epidemiology/ethnology
Blood Glucose/*metabolism
*Blood Pressure
*Body Mass Index
Cholesterol/*metabolism
Coronary Disease/epidemiology/ethnology
Diet/*statistics & numerical data
Diet, Healthy/statistics & numerical data
Educational Status
Electrocardiography
European Continental Ancestry Group/statistics & numerical data
*Exercise
Female
Humans
Hypertrophy, Left Ventricular/epidemiology/ethnology
Income/statistics & numerical data
Logistic Models
Male
Middle Aged
Odds Ratio
Risk Assessment
Sex Factors
Smoking/*epidemiology
Stroke/epidemiology/ethnology
LA - eng
N1 - 1879-1913
Garg, Parveen K
O'Neal, Wesley T
Ogunsua, Adedotun
Thacker, Evan L
Howard, George
Soliman, Elsayed Z
Cushman, Mary
F32 HL134290/HL/NHLBI NIH HHS/United States
Journal Article
Am J Cardiol. 2018 Jan 15;121(2):199-204. doi: 10.1016/j.amjcard.2017.09.033. Epub
2017 Oct 19.
PY - 2018
SN - 0002-9149 (Print)
0002-9149
SP - 199-204
ST - Usefulness of the American Heart Association's Life Simple 7 to Predict the
Risk of Atrial Fibrillation (from the REasons for Geographic And Racial Differences
in Stroke [REGARDS] Study)
T2 - Am J Cardiol
TI - Usefulness of the American Heart Association's Life Simple 7 to Predict the
Risk of Atrial Fibrillation (from the REasons for Geographic And Racial Differences
in Stroke [REGARDS] Study)
VL - 121
ID - 2407
ER -
TY - JOUR
AB - In a 6 month prospective study of 232 patients with cerebral ischaemia, 100
(43%) had a prior history of heart disease. In 22 of the patients with prior heart
disease an unsuspected cardiac disorder was subsequently detected (6 atrial
fibrillation, 13 cardiomegaly or left ventricular hypertrophy and 3 ischaemic heart
disease). In patients without prior heart disease, 47 (20%) were found to have
cardiac disease: 6 atrial fibrillation, 31 cardiomegaly or left ventricular
hypertrophy 9 ischaemic heart disease and 1 left bundle branch block. Previously
unsuspected or asymptomatic cardiac disease is common in patients with cerebral
ischaemia.
AD - Department of Medicine, St Vincent's Hospital, Melbourne, Victoria.
AN - 2959410
AU - Gates, P.
AU - Peppard, R.
AU - Kempster, P.
AU - Harris, A.
AU - Pierce, M.
DP - NLM
ET - 1987/01/01
J2 - Clinical and experimental neurology
KW - Adult
Aged
Aged, 80 and over
Angina Pectoris/complications
Arrhythmias, Cardiac/complications
Cardiomegaly/complications
Cerebral Infarction/complications
Electrocardiography
Female
Humans
Male
Middle Aged
Risk Factors
LA - eng
N1 - Gates, P
Peppard, R
Kempster, P
Harris, A
Pierce, M
Journal Article
Australia
Clin Exp Neurol. 1987;23:75-80.
PY - 1987
SN - 0196-6383 (Print)
0196-6383
SP - 75-80
ST - Clinically unsuspected cardiac disease in patients with cerebral ischaemia
T2 - Clin Exp Neurol
TI - Clinically unsuspected cardiac disease in patients with cerebral ischaemia
VL - 23
ID - 2578
ER -
TY - JOUR
AB - BACKGROUND: We evaluated the in-hospital and long-term effects of surgical
grafting of a dominant graftable right coronary artery tributary of an infarcted
nonischemic territory in patients with triple-vessel disease who were undergoing
coronary artery bypass grafting. METHODS: Of 303 consecutive patients undergoing
coronary artery bypass grafting with 3-vessel coronary disease and a dominant right
coronary artery tributary of an infarcted nonischemic territory, 154 were
randomized to right coronary artery revascularization and 149 to no right coronary
artery grafting. In all cases, standard on-pump surgical myocardial
revascularization was performed. RESULTS: Overall hospital mortality was 2 of 154
versus 1 of 149 (P =.97); no difference in in-hospital outcome was observed between
the 2 groups. At follow-up, cardiac event-free survival was 84 of 152 in the right
coronary artery grafting series and 62 of 148 in the non-right coronary artery
grafting group (P =.20). However, when the analysis was limited to surviving
patients without new scintigraphic evidence of ischemia (to avoid confounding
factors derived from ischemia in the left coronary system or right coronary artery
graft malfunction), we found that patients who received a right coronary artery
graft had fewer cardiac events, a lower incidence of arrhythmia, and less left
ventricular dilatation than did the non-right coronary artery revascularized
series. CONCLUSIONS: Surgical grafting of a right coronary artery tributary of an
infarcted nonischemic territory in patients with 3-vessel coronary artery disease
submitted to coronary artery bypass grafting improved late electric stability,
ventricular geometry, and event-free survival but did not affect in-hospital or 10-
year survival.
AD - Department of Cardia Surgery, Catholic University, Rome, Italy.
mgaudino@tiscali.it
AN - 14762352
AU - Gaudino, M.
AU - Alessandrini, F.
AU - Glieca, F.
AU - Luciani, N.
AU - Cellini, C.
AU - Pragliola, C.
AU - Morelli, M.
AU - Girola, F.
AU - Possati, G.
DA - Feb
DO - 10.1016/j.jtcvs.2003.08.026
DP - NLM
ET - 2004/02/06
IS - 2
KW - Aged
*Coronary Artery Bypass
Coronary Artery Disease/diagnosis/mortality/*surgery
Echocardiography
Female
Follow-Up Studies
Heart Ventricles/diagnostic imaging/physiopathology
Hospital Mortality
Humans
Italy/epidemiology
Length of Stay
Male
Middle Aged
Mitral Valve Insufficiency/diagnosis/etiology
Morbidity
Myocardial Ischemia/diagnosis/mortality/surgery
Postoperative Complications/diagnosis/etiology/mortality
Prospective Studies
Recurrence
Respiratory Insufficiency/diagnosis/etiology/mortality
Stroke/diagnosis/etiology/mortality
Time
Treatment Outcome
LA - eng
N1 - Gaudino, Mario
Alessandrini, Francesco
Glieca, Franco
Luciani, Nicola
Cellini, Carlo
Pragliola, Claudio
Morelli, Mauro
Girola, Fabiana
Possati, Gianfederico
Clinical Trial
Comparative Study
Journal Article
United States
J Thorac Cardiovasc Surg. 2004 Feb;127(2):435-9. doi: 10.1016/j.jtcvs.2003.08.026.
PY - 2004
SN - 0022-5223 (Print)
0022-5223
SP - 435-9
ST - Effect of surgical revascularization of a right coronary artery tributary of
an infarcted nonischemic territory on the outcome of patients with three-vessel
disease: a prospective randomized trial
TI - Effect of surgical revascularization of a right coronary artery tributary of
an infarcted nonischemic territory on the outcome of patients with three-vessel
disease: a prospective randomized trial
VL - 127
ID - 2863
ER -
TY - JOUR
AB - INTRODUCTION Non-vitamin K antagonist oral anticoagulants (NOACs) are an
alternative to vitamin K antagonists (VKAs) for stroke prevention in atrial
fibrillation (AF). OBJECTIVES The aim of the study was to assess the incidence
of left atrial appendage (LAA) thrombus and dense spontaneous echo contrast (SEC),
as well as to compare the clinical characteristics of patients with AF treated with
different anticoagulant regimens. PATIENTS AND METHODS We studied 1033
consecutive patients with AF, who underwent transesophageal echocardiography (TEE)
before AF ablation or cardioversion. We excluded 174 patients without any prior
oral anticoagulation or who underwent bridging with heparin before TEE. RESULTS
In the study group of 859 patients (median age, 61 years; men, 66%), 437 patients
(50.9%) received VKAs; 191 (22.2%), dabigatran; 230 (26.8%), rivaroxaban; and 1
patient (0.1%), apixaban. There were no differences in baseline characteristics or
the incidence of LAA thrombus (VKAs, 6.9%; NOACs, 5.5%; P = 0.40) and dense SEC
(VKAs, 5.3%; NOACs, 3.3%; P = 0.18) between patients on VKAs and those on NOACs.
Compared with patients treated with dabigatran, those on rivaroxaban more often had
paroxysmal AF, higher ejection fraction, LAA emptying velocity, and platelet count,
as well as lower left ventricular end-diastolic dimension and hematocrit. The
frequency of LAA thrombus in patients receiving dabigatran and those receiving
rivaroxaban was comparable (6.8% vs 4.4%; P = 0.29), while dense SEC occurred more
often in patients treated with dabigatran (5.2% vs 1.7%; P = 0.06). In a logistic
regression analysis, none of the oral anticoagulation regimens predicted LAA
thrombus in TEE, whereas maximal LAA emptying velocity was the only parameter
independently associated with the presence of thrombus. CONCLUSIONS In the
studied group of patients with AF, the choice of anticoagulation did not depend on
thromboembolic or bleeding risk.
AN - 28972957
AU - Gawałko, M.
AU - Kapłon-Cieślicka, A.
AU - Budnik, M.
AU - Babiarz, A.
AU - Bodys, A.
AU - Uliński, R.
AU - Żochowski, M.
AU - Peller, M.
AU - Scisło, P.
AU - Kochanowski, J.
AU - Filipiak, K. J.
AU - Opolski, G.
DA - Dec 22
DO - 10.20452/pamw.4117
DP - NLM
ET - 2017/10/04
IS - 12
J2 - Polish archives of internal medicine
Aged
Antithrombins/administration & dosage/adverse effects/*therapeutic use
Dabigatran/administration & dosage/adverse effects/therapeutic use
Female
Humans
Incidence
Male
Middle Aged
Pyrazoles/administration & dosage/adverse effects/therapeutic use
Pyridones/administration & dosage/adverse effects/therapeutic use
Rivaroxaban/administration & dosage/adverse effects/therapeutic use
Thromboembolism/*chemically induced/epidemiology
LA - eng
N1 - 1897-9483
Gawałko, Monika
Kapłon-Cieślicka, Agnieszka
Budnik, Monika
Babiarz, Aldona
Bodys, Aleksandra
Uliński, Robert
Żochowski, Maciej
Peller, Michał
Scisło, Piotr
Kochanowski, Janusz
Filipiak, Krzysztof J
Opolski, Grzegorz
Comparative Study
Journal Article
Poland
Pol Arch Intern Med. 2017 Dec 22;127(12):823-831. doi: 10.20452/pamw.4117. Epub
2017 Sep 30.
PY - 2017
SN - 0032-3772
SP - 823-831
ST - Comparison of different oral anticoagulant regimens in patients with atrial
fibrillation undergoing ablation or cardioversion
T2 - Pol Arch Intern Med
TI - Comparison of different oral anticoagulant regimens in patients with atrial
fibrillation undergoing ablation or cardioversion
VL - 127
ID - 2833
ER -
TY - JOUR
AB - BACKGROUND: Patients with atrial fibrillation (AF) have a higher risk of
fatal complications (e.g., stroke). This investigation was performed as an
observational retrospective cohort study includes 137 patients (age 61 ± 15; 34.3%
women) with a primary diagnosis of AF (paroxysmal, persistent, and permanent).
METHODS: We collected information about the drug therapy, comorbidities and
survival of AF patients and determined their congestive heart failure,
hypertension, age, diabetes mellitus, prior stroke or TIA or thromboembolism,
vascular disease, age, sex category (CHA2DS2-VASc) scores. Statistical analysis
identified patients with high CHA2DS2-VASc scores and defined the predictive value
of individual parameters, or their combination, with regards to the outcomes of
stroke and mortality. RESULTS: CHA2DS2-VASc scores identified 43.8% of the patients
as low to intermediate risk (score 0-1) and 56.2% of the patients as high risk
(score ≥2). Increasing CHA2DS2-VASc scores were not only accompanied by an increase
in the incidence of stroke (Ptrend < .001) but also by an increase in the 3 to 5
years mortality (P = .005). Comparison of anticoagulation and anti-aggregation
treatment between the 3 groups of AF did not show any significant statistical
difference. Highly significant predictors of death were the CHA2DS2-VASc score (OR
1.71, 95% CI 1.10-2.67, P < .017) as well as other risk factors not included in the
CHA2DS2-VASc score such as valvular heart disease (OR 5.04, 95% CI 1.10-23.10, P
= .037), hyperlipidemia (OR 4.82, 95% CI 1.03-22.63, P = .046) and chronic renal
failure (OR 14.21, 95% CI 2.41-83.91, P = .003). The type of AF type did not affect
survival (P = .158) nor the incidence of stroke (P = .466). Patients with
paroxysmal AF were linked to significantly lower frequencies of ischemic heart
disease (P < .0001), vascular disease (P = .002), diabetes mellitus (P = .047),
valvular heart disease (P = .03) and heart failure/left ventricular dysfunction (P
= .015). CONCLUSION: The CHA2DS2-VASc score correctly predicted the patients at
high-risk for 3 to 5 years mortality and confirmed its significant predictive value
in the patients with AF.
AD - Institute of Pharmacology and Clinical Pharmacology, Faculty of Medicine
Comenius University, Špitálska 24,Bratislava, Slovakia.
Department of Cellular and Molecular Medicine, Faculty of Medicine, University of
Ottawa, Ottawa, Canada.
V. Department of Internal Medicine, Faculty of Medicine, Comenius University,
Špitálska 24.
Department of Arrhythmias and Cardiac Pacing, The National Institute of
Cardiovascular Diseases and Faculty of Medicine, Slovak Medical University, Pod
Krasnou Horkou 1, Bratislava, Slovakia.
AN - 31374021
AU - Gažová, A.
AU - Leddy, J. J.
AU - Rexová, M.
AU - Hlivák, P.
AU - Hatala, R.
AU - Kyselovič, J.
C2 - PMC6708930
DA - Aug
DO - 10.1097/md.0000000000016560
DP - NLM
ET - 2019/08/03
IS - 31
J2 - Medicine
KW - Age Factors
Aged
Atrial Fibrillation/*complications/mortality
Cohort Studies
Diabetes Mellitus/classification
Female
Heart Failure/classification/complications
Humans
Hypertension/classification/complications
Logistic Models
Male
Middle Aged
Research Design/*standards
Stroke/*mortality/physiopathology
Thromboembolism/classification/complications
LA - eng
N1 - 1536-5964
Gažová, Andrea
Leddy, John J
Rexová, Mária
Hlivák, Peter
Hatala, Róbert
Kyselovič, Jan
Journal Article
Observational Study
Medicine (Baltimore). 2019 Aug;98(31):e16560. doi: 10.1097/MD.0000000000016560.
PY - 2019
SN - 0025-7974 (Print)
0025-7974
SP - e16560
ST - Predictive value of CHA2DS2-VASc scores regarding the risk of stroke and all-
cause mortality in patients with atrial fibrillation (CONSORT compliant)
TI - Predictive value of CHA2DS2-VASc scores regarding the risk of stroke and all-
cause mortality in patients with atrial fibrillation (CONSORT compliant)
VL - 98
ID - 2364
ER -
TY - JOUR
AB - BACKGROUND: Hemodialysis (HD) is associated with cardiovascular structural
modifications; moreover, during HD, rapid electrolytic changes occur. Both factors
may favor the onset of atrial fibrillation. METHODS: To define the prevalence of
atrial fibrillation and identify associated factors, 488 patients on long-term HD
therapy (age, 66.6 +/- 13.4 years; men, 58.0%; duration of HD, 76.5 +/- 84.3
months) were studied. RESULTS: Atrial fibrillation was reported in 27.0% of
patients; paroxysmal in 3.5%, persistent in 9.6%, and permanent in 13.9%. Clinical
and echocardiographic variables were considered: patients with atrial fibrillation
were older (71.8 +/- 9.3 versus 64.7 +/- 14.2 years; P < 0.01), and its prevalence
increased with age. Patients with arrhythmia had a longer duration of dialysis
therapy (93.2 +/- 100.5 versus 70.2 +/- 76.7 months; P = 0.02). Atrial fibrillation
was associated significantly with ischemic heart disease (P < 0.01), dilated
cardiomyopathy (P < 0.01), acute pulmonary edema (P < 0.05), valvular disease (P <
0.05), cerebrovascular accidents (P < 0.05), and predialytic hyperkalemia (P <
0.05). Patients with atrial fibrillation more frequently showed left atrial
dilatation (59.8% versus 34.5%; P < 0.0001), and in these subjects, left
ventricular ejection fraction was significantly lower (53.9% versus 57.4%; P =
0.029). No association was found between arrhythmia and hypertension or diabetes.
Multivariate analysis confirmed that patient age (P < 0.001), duration of HD
therapy (P = 0.001), and left atrial dilatation (P < 0.001) were associated with
atrial fibrillation. CONCLUSION: Atrial fibrillation is much more frequent in HD
patients than in the general population; age, duration of HD history, presence of
some heart diseases, and left atrial dilatation are associated with the arrhythmia.
AD - Dipartimento di Medicina Clinica Prevenzione e Biotecnologie Sanitarie,
Università degli Studi Milano, Bicocca, Italy. simonetta.genovesi@unimib.it
AN - 16253730
AU - Genovesi, S.
AU - Pogliani, D.
AU - Faini, A.
AU - Valsecchi, M. G.
AU - Riva, A.
AU - Stefani, F.
AU - Acquistapace, I.
AU - Stella, A.
AU - Bonforte, G.
AU - DeVecchi, A.
AU - DeCristofaro, V.
AU - Buccianti, G.
AU - Vincenti, A.
DA - Nov
DO - 10.1053/j.ajkd.2005.07.044
DP - NLM
ET - 2005/10/29
IS - 5
J2 - American journal of kidney diseases : the official journal of the National
Kidney Foundation
KW - Adult
Age Factors
Aged
Aged, 80 and over
Atrial Fibrillation/diagnostic imaging/*epidemiology/etiology
Cohort Studies
Comorbidity
Female
Heart Diseases/epidemiology
Humans
Hyperkalemia/epidemiology
Italy/epidemiology
Kidney Failure, Chronic/complications/*epidemiology/therapy
Male
Middle Aged
Prevalence
Pulmonary Disease, Chronic Obstructive/epidemiology
Pulmonary Edema/epidemiology
*Renal Dialysis/adverse effects
Stroke/epidemiology
Time Factors
Ultrasonography
LA - eng
N1 - 1523-6838
Genovesi, Simonetta
Pogliani, Daniela
Faini, Andrea
Valsecchi, Maria G
Riva, Alessandra
Stefani, Francesca
Acquistapace, Irene
Stella, Andrea
Bonforte, Giuseppe
DeVecchi, Amedeo
DeCristofaro, Vincenzo
Buccianti, Gherardo
Vincenti, Antonio
Journal Article
Multicenter Study
United States
Am J Kidney Dis. 2005 Nov;46(5):897-902. doi: 10.1053/j.ajkd.2005.07.044.
PY - 2005
SN - 0272-6386
SP - 897-902
ST - Prevalence of atrial fibrillation and associated factors in a population of
long-term hemodialysis patients
T2 - Am J Kidney Dis
TI - Prevalence of atrial fibrillation and associated factors in a population of
long-term hemodialysis patients
VL - 46
ID - 2536
ER -
TY - JOUR
AB - BACKGROUND: Atrial fibrillation is associated with increased mortality and
hospitalization in the general population. Data about mortality, morbidity, and
hospitalization in hemodialysis patients with atrial fibrillation are limited.
SETTING & PARTICIPANTS: All patients (n = 476) in 5 dialysis centers in Lombardia,
Italy, as of June 2003 were enrolled and followed up until June 2006 (median age,
69 years; median hemodialysis duration, 45.2 months; and median follow-up, 36
months). 127 patients had atrial fibrillation at enrollment. PREDICTORS & OUTCOME:
A Cox model was used to relate: (1) atrial fibrillation, age, hemodialysis therapy
duration, and comorbid conditions to all-cause and cardiovascular mortality; (2)
angiotensin-converting enzyme (ACE)-inhibitor treatment and comorbid conditions to
new onset of atrial fibrillation; and (3) atrial fibrillation and comorbid
conditions on hospitalization. RESULTS: There were 167 deaths (39.5% from
cardiovascular disease). In multivariable models, atrial fibrillation was
independently associated with increased mortality (hazard ratio [HR], 1.65; 95%
confidence interval [CI], 1.18 to 2.31). This was more notable for cardiovascular
(HR, 2.15; 95% CI, 1.27 to 3.64) than noncardiovascular mortality (HR, 1.39; 95%
CI, 0.89 to 2.15). New-onset atrial fibrillation occurred in 35 of 349 individuals
(4.1 events/100 person-years); the risk of incident atrial fibrillation was lower
in those using ACE-inhibitor therapy (HR, 0.29; 95% CI, 0.10 to 0.82) and higher in
those with left ventricular hypertrophy (HR, 2.55; 95% CI, 1.04 to 6.26). There
were 539 hospitalizations during 3 years, with 114 hospitalizations in 162 patients
with atrial fibrillation and 155 hospitalizations in 314 patients without atrial
fibrillation (HR, 1.54; 95% CI, 1.18 to 2.01). Rates of stroke did not
significantly differ by atrial fibrillation status (P = 0.4). LIMITATIONS: Because
of the observational nature of this study, results for treatment need confirmation
in future trials. CONCLUSIONS: Atrial fibrillation is associated with greater total
and cardiovascular mortality. Patients with atrial fibrillation were hospitalized
more frequently than patients without atrial fibrillation. ACE inhibitors may
decrease the risk of new-onset atrial fibrillation.
AD - Dipartimento di Medicina Clinica e Prevenzione, Università degli Studi di
Milano-Bicocca, Monza, Italy. simonetta.genovesi@unimib.it
AN - 18215703
AU - Genovesi, S.
AU - Vincenti, A.
AU - Rossi, E.
AU - Pogliani, D.
AU - Acquistapace, I.
AU - Stella, A.
AU - Valsecchi, M. G.
DA - Feb
DO - 10.1053/j.ajkd.2007.10.034
DP - NLM
ET - 2008/01/25
IS - 2
Kidney Foundation
KW - Aged
Angiotensin-Converting Enzyme Inhibitors/*therapeutic use
Atrial Fibrillation/*epidemiology/*etiology/mortality/prevention & control
Cardiovascular Diseases/*complications/drug therapy
Cause of Death
Cohort Studies
Comorbidity
Female
Follow-Up Studies
Hemodiafiltration/*adverse effects
Humans
Incidence
Italy/epidemiology
Male
Middle Aged
Odds Ratio
Renal Dialysis/mortality
Research Design
LA - eng
N1 - 1523-6838
Genovesi, Simonetta
Vincenti, Antonio
Rossi, Emanuela
Pogliani, Daniela
Acquistapace, Irene
Stella, Andrea
Valsecchi, Maria Grazia
Journal Article
Multicenter Study
United States
Am J Kidney Dis. 2008 Feb;51(2):255-62. doi: 10.1053/j.ajkd.2007.10.034.
PY - 2008
SN - 0272-6386
SP - 255-62
ST - Atrial fibrillation and morbidity and mortality in a cohort of long-term
hemodialysis patients
TI - Atrial fibrillation and morbidity and mortality in a cohort of long-term
hemodialysis patients
VL - 51
ID - 2648
ER -
TY - JOUR
AB - BACKGROUND AND PURPOSE: We undertook this study to evaluate the prevalence
and clinical correlations of Doppler microembolic signals (MES) in stroke-prone
patients. METHODS: Patients with potential cardiac (n = 300) or carotid (n = 100)
embolic source and control subjects (n = 100) were monitored with transcranial
Doppler sonography for MES. Transthoracic (n = 192) and/or transesophageal (n =
134) echocardiography and carotid studies (continuous-wave Doppler, n = 181; color-
coded duplex, n = 47) were performed in all patients with potential native
cardioembolic source. Carotid disease was evaluated by means of continuous-wave
Doppler (n = 87), color-coded duplex (n = 70), or intra-arterial angiography (n =
24) in patients with potential carotid embolic source. RESULTS: Overall MES
prevalence was 23% in patients with potential native cardioembolic source
(infective endocarditis [n = 7] 43%, left ventricular aneurysm [n = 38] 34%,
intracardiac thrombus [n = 23] 26%, dilative cardiomyopathy [n = 39] 26%,
nonvalvular atrial fibrillation [n = 24] 21%, valvular disease [n = 80] 15%), 55%
in patients with prosthetic cardiac valves (mechanical [n = 77] 58%, porcine [n =
7] 43%, homografts [n = 5] 20%), 28% in patients with carotid disease (symptomatic
[n = 46] 52%, asymptomatic [n = 54] 7%; P < .01), and 5% in control subjects. No
relationship between MES counts and patients' age, sex, or actual medication was
noted. The sensitivity and specificity of MES detection in identifying patients
with potential embolic sources were 31% and 95%, respectively. CONCLUSIONS: Our
study confirmed the reported clinical significance of MES in patients with carotid
disease and the high specificity of this technique. The demonstrated low
sensitivity of MES detection could be due to short monitoring duration or
application of antihemostatic treatment. Prospective large-scale studies are needed
to determine the definitive value of MES detection as a diagnostic method in
patients with potential cardioembolic source.
AD - Department of Neurology, University of Halle, Germany.
dimitrios.georgiadis@medizin.uni-halle.de
AN - 9183352
AU - Georgiadis, D.
AU - Lindner, A.
AU - Manz, M.
AU - Sonntag, M.
AU - Zunker, P.
AU - Zerkowski, H. R.
AU - Borggrefe, M.
DA - Jun
DO - 10.1161/01.str.28.6.1203
DP - NLM
ET - 1997/06/01
IS - 6
J2 - Stroke
KW - Adult
Angiography
Cardiomyopathy, Dilated/complications
Carotid Artery Diseases/complications/*diagnostic imaging
Coronary Thrombosis/*diagnostic imaging
Echocardiography
Embolism/*diagnostic imaging
Female
Heart Valve Diseases/complications
Heart Valve Prosthesis/adverse effects
Humans
Intracranial Embolism and Thrombosis/*diagnostic imaging
Male
Middle Aged
Ultrasonography, Doppler, Color
*Ultrasonography, Doppler, Transcranial
LA - eng
N1 - Georgiadis, D
Lindner, A
Manz, M
Sonntag, M
Zunker, P
Zerkowski, H R
Borggrefe, M
Journal Article
United States
Stroke. 1997 Jun;28(6):1203-7. doi: 10.1161/01.str.28.6.1203.
PY - 1997
SN - 0039-2499 (Print)
0039-2499
SP - 1203-7
ST - Intracranial microembolic signals in 500 patients with potential cardiac or
carotid embolic source and in normal controls
T2 - Stroke
TI - Intracranial microembolic signals in 500 patients with potential cardiac or
carotid embolic source and in normal controls
VL - 28
ID - 3055
ER -
TY - JOUR
AB - OBJECTIVE: Evaluate long-term outcomes in patients undergoing the Convergent
procedure (CP) for the treatment of atrial fibrillation (AF). BACKGROUND: The CP
provides a multidisciplinary approach, combining endoscopic creation of epicardial
linear lesions followed by endocardial mapping and ablation and targets persistent
and longstanding persistent AF patients who are at increased risk of heart failure,
stroke, and mortality. METHODS: Outcomes from a prospective nonrandomized study
were recorded for consecutive patients by interrogation of implanted Reveal
monitors. Rhythm status and AF burden were quantified 6-24 months postprocedure,
and compared relative to AF type, gender, age, body mass index, left atrial size,
left ventricular ejection fraction, and congestive heart failure, hypertension, age
>75 years, age between 65 and 74 years, stroke/TIA/TE, vascular disease (previous
MI, peripheral arterial disease or aortic plaque), diabetes mellitus, female
(CHA(2) DS(2) VASc). RESULTS: A total of 50 patients were enrolled with 94% having
persistent or longstanding persistent AF. There were 2 atrioesophageal fistulas
reported. In one patient, the fistula resulted in death at 33 days postprocedure;
in the second, the fistula was surgically repaired but patient died 8 months
postprocedure from a CVI. After CP, 95% of patients were in sinus rhythm at 6-month
follow-up; 88% at 12 months; and 87% at 24 months. The median AF burden recorded
with Reveal XT monitors was 0.0%, 0.1%, and 0.1% at 6, 12, and 24 months with 81%,
81%, and 87% of patients reporting a burden less than 3%, respectively. CONCLUSION:
Using 24 × 7 continuous loop recording, the CP demonstrated success in treating
persistent and longstanding persistent AF patients. Endocardial mapping and
catheter ablation with diagnostic confirmation of procedural success complemented
the endoscopic creation of epicardial linear lesions in restoring sinus rhythm.
AD - Department of Cardiovascular Surgery, University Medical Center Ljubljana,
Zaloska, Ljubljana, Slovenia. bgersak@maat.si
AN - 22587585
AU - Gersak, B.
AU - Pernat, A.
AU - Robic, B.
AU - Sinkovec, M.
DA - Oct
DO - 10.1111/j.1540-8167.2012.02355.x
DP - NLM
ET - 2012/05/17
IS - 10
KW - Adult
Aged
Atrial Fibrillation/diagnosis/mortality/physiopathology/*surgery
Catheter Ablation/adverse effects/*methods/mortality
*Electrophysiologic Techniques, Cardiac/instrumentation
Endocardium/physiopathology/*surgery
Equipment Design
Female
*Heart Rate
Humans
Logistic Models
Male
Middle Aged
*Monitoring, Ambulatory/instrumentation
Pericardium/physiopathology/*surgery
Postoperative Complications/etiology/mortality
Prospective Studies
Recurrence
Risk Factors
*Telemetry/instrumentation
Time Factors
Treatment Outcome
LA - eng
N1 - 1540-8167
Gersak, Borut
Pernat, Andrej
Robic, Boris
Sinkovec, Matjaz
Journal Article
United States
J Cardiovasc Electrophysiol. 2012 Oct;23(10):1059-66. doi: 10.1111/j.1540-
8167.2012.02355.x. Epub 2012 May 15.
PY - 2012
SN - 1045-3873
SP - 1059-66
ST - Low rate of atrial fibrillation recurrence verified by implantable loop
recorder monitoring following a convergent epicardial and endocardial ablation of
atrial fibrillation
TI - Low rate of atrial fibrillation recurrence verified by implantable loop
recorder monitoring following a convergent epicardial and endocardial ablation of
atrial fibrillation
VL - 23
ID - 2956
ER -
TY - JOUR
AB - BACKGROUND: Although brain natriuretic peptide (BNP) levels are shown to be
an important prognostic factor in patients with acute myocardial infarction (MI),
the relationship between arrhythmias and BNP levels is not known. This study
assessed whether baseline clinical factors, N-terminal-proBNP (NT-proBNP) levels
and electrocardiographic patterns of acute inferior MI are associated with greater
risk of developing complete atrioventricular block (CAVB) and mortality. METHODS
AND RESULTS: Seventy-nine consecutive patients (52 male, 27 female with an avarage
age of 64.2 ± 10.9 years) with CAVB and 119 control patients (93 male, 16 female
with an average age of 57.7 ± 11.4 years) without CAVB were enrolled. Regression
analysis revealed that NT-proBNP levels 〉 104 pg/mL increased the development of
CAVB by 16.7 folds, 〉 1 mm ST elevation in RV4 by 2.7 folds, ratio of elevation in
lead III:II 〉 1.5 by 10.1 folds but the thrombolytic therapy decreased the
development of CAVB by 2.8 folds. NT-proBNP 〉 92 pg/mL increased the mortality by
8.9 folds, a ratio of ST-segment elevation in lead III:II 〉 1 by 3.1 folds, ST
segment elevation 〉 1 mm in RV4 by 3.5 folds, ejection fraction 〈 35% by 24.2
folds, age 〉 65 years by 8.3 folds and CAVB by 6.8 folds, on contrary thrombolytic
treatment decreased the mortality by 3.3 folds. CONCLUSIONS: Simple
electrocardiographic measurements and NT-proBNP levels at admission can be used as
a screening test for development of complications such as CAVB, right ventricular
involvement and mortality during acute inferior wall MI.
AD - Department of Cardiology, Trakya University School of Medicine, Edirne,
Turkey.
AN - 23042311
AU - Geyik, B.
AU - Ozdemir, O.
AU - Osmonov, D.
AU - Soylu, M. O.
DO - 10.5603/cj.2012.0088
DP - NLM
ET - 2012/10/09
IS - 5
J2 - Cardiology journal
KW - Age Factors
Aged
Atrioventricular
Block/blood/diagnosis/*etiology/*mortality/physiopathology/prevention & control
Biomarkers/blood
Female
Hospital Mortality
Humans
Inferior Wall Myocardial
Infarction/blood/*complications/diagnosis/*mortality/physiopathology/therapy
Logistic Models
Male
Middle Aged
Risk Assessment
Risk Factors
Thrombolytic Therapy
Up-Regulation
Ventricular Function, Right
LA - eng
N1 - 1897-5593
Geyik, Bilal
Ozdemir, Ozcan
Osmonov, Damirbek
Soylu, Mustafa Ozcan
Journal Article
Poland
Cardiol J. 2012;19(5):479-86. doi: 10.5603/cj.2012.0088.
PY - 2012
SN - 1898-018x
SP - 479-86
ST - N-terminal pro-brain natriuretic peptide and electrocardiographic variables
associated with increased risk of complete atrioventricular block and mortality in
patients with acute inferior myocardial infarction
T2 - Cardiol J
TI - N-terminal pro-brain natriuretic peptide and electrocardiographic variables
associated with increased risk of complete atrioventricular block and mortality in
patients with acute inferior myocardial infarction
VL - 19
ID - 2953
ER -
TY - JOUR
AB - A 43 year-old woman, with uterine bleeding and right ovary cyst, was
scheduled for hysteroscopy-curettage and laparoscopy. Her history was unremarkable.
After induction of general anaesthesia and tracheal intubation (propofol, fentanyl,
vecuronium), anesthesia was maintained with N2O/O2 (60%/40%) and isoflurane 1 vol
%. The patient was placed in the dorsal lithotomy position. Two minutes after the
beginning of CO2 insufflation for hysteroscopy, a ventricular tachycardia with a
circulatory arrest suddenly occurred. Insufflation was stopped, cardiopulmonary
resuscitation started and lignocaine 100 mg iv administered. The haemodynamic
status improved rapidly with a return to sinusal rhythm and stable blood pressure
within two minutes. In the recovery room, the patient was restless and experienced
blindness for 3 hours. Physical examination and all investigations (EEG, brain CT
scan, carotid Doppler and transoesophageal echocardiography) were normal. The most
probable diagnosis was a CO2 venous embolism associated with an arterial paradoxal
embolism responsible for the temporary blindness.
AD - Département d'anesthésie et de réanimation, hôpital Lariboisière, Paris,
France.
AN - 8734240
AU - Ghimouz, A.
AU - Loisel, B.
AU - Kheyar, M.
AU - Fried, D.
AU - Bouret, J. M.
DO - 10.1016/0750-7658(96)85042-8
DP - NLM
ET - 1996/01/01
IS - 2
J2 - Annales francaises d'anesthesie et de reanimation
KW - Adult
Blindness/*etiology
*Carbon Dioxide
Embolism, Air/*etiology
Female
Humans
Hysteroscopy/*adverse effects/methods
Tachycardia, Ventricular/etiology
LA - fre
N1 - Ghimouz, A
Loisel, B
Kheyar, M
Fried, D
Bouret, J M
Case Reports
English Abstract
Journal Article
Review
France
Ann Fr Anesth Reanim. 1996;15(2):192-5. doi: 10.1016/0750-7658(96)85042-8.
OP - Embolie de CO2 lors d'une hystéroscopie suivie de cécité transitoire.
PY - 1996
SN - 0750-7658 (Print)
0750-7658
SP - 192-5
ST - [Carbon dioxide embolism during hysteroscopy followed by transient blindness]
T2 - Ann Fr Anesth Reanim
TI - [Carbon dioxide embolism during hysteroscopy followed by transient blindness]
VL - 15
ID - 3007
ER -
TY - JOUR
AB - The prevalence of intracardiac thrombi in patients with dilated
cardiomyopathy is very variable from one study to another, but is generally high:
20 to 25% for interatrial thrombi and 50% for intraventricular thrombi. There is
also a high incidence of left atrial spontaneous contrast (30-40%). Left atrial
thrombosis or spontaneous contrast is more common in atrial fibrillation, when the
LA diameter is increased with low velocity intra-left atrial blood flow on Doppler
examination and when there are disturbances of haemorrheological factors (increased
fibrinogen levels and plasma viscosity). Ventricular thrombi are more common when
the fractional shortening is decreased (< 11% = 80% of thrombi). The frequency of
embolism is controversial. It varies between 1.4 and 12 events per 100 patients per
year. The risk of complications is higher in patients with intracavitary
thrombosis. The number of cerebral haemorrhagic complications in patients on long-
term oral anticoagulants is far from negligible. Large prospective multicenter
trials should be instituted, as for atrial fibrillation to evaluate systematic
anticoagulation with respect to the risks. In the meantime, it would seem to be
prudent to prescribe oral anticoagulants to all patients with dilated
cardiomyopathy with an intracardiac thrombus and/or atrial fibrillation, and to
perform echocardiography regularly when left ventricular function is very poor.
AD - Service de cardiologie (Pr P. Morand), hôpital Pasteur, CHU de Nice.
AN - 7487312
AU - Gibelin, P.
DA - Apr
DP - NLM
ET - 1995/04/01
IS - 4 Suppl
Cardiomyopathy, Dilated/complications/*drug therapy
Humans
Prevalence
Risk Factors
Thromboembolism/*epidemiology/etiology/prevention & control
Thrombosis/diagnostic imaging/*epidemiology/etiology
LA - fre
N1 - Gibelin, P
Journal Article
France
Arch Mal Coeur Vaiss. 1995 Apr;88(4 Suppl):617-21.
OP - Traitement anticoagulant et cardiomyopathie dilatée.
PY - 1995
SN - 0003-9683 (Print)
0003-9683
SP - 617-21
ST - [Anticoagulant treatment and dilated cardiomyopathy]
TI - [Anticoagulant treatment and dilated cardiomyopathy]
VL - 88
ID - 3009
ER -
TY - JOUR
AB - This article compares the important differences in the American College of
Cardiology Foundation (ACCF)/American Heart Association (AHA)/Heart Rhythm Society
(HRS), Canadian Cardiovascular Society (CCS), and European Society of Cardiology
(ESC) 2010 guidelines on atrial fibrillation (AF). All guidelines recommend more
lenient targets for ventricular rate control although the CCS guidelines recommend
a target heart rate at rest <100 bpm whereas the the ACCF/AHA/HRS and ESC
guidelines accept a target heart rate at rest <110 bpm with provisos. All the
guidelines recommend that the choice of antiarrhythmic drug for maintenance of
sinus rhythm be based on the underlying cardiovascular disease state. However, the
CCS guidelines do not recommend that the use of Class IC drugs or sotalol be
restricted in the presence of left ventricular hypertrophy alone. All the
guidelines have incorporated dronedarone into their recommendations of
antiarrhythmic drug therapy for maintenance of sinus rhythm. However, the CCS
guidelines do not make a specific recommendation that the use of dronedarone is
reasonable to decrease the risk of hospitalization for cardiovascular causes in
patients with AF. The ACCF/AHA/HRS update makes a strong recommendation for
catheter ablation in patients with paroxysmal AF who have failed a single anti-
arrhythmic drug whereas the CCS and ESC guidelines make this a conditional
recommendation. The CCS guidelines are the only guidelines at present that
recommend dabigitran for prevention of stroke in high risk patients and suggest
that dabigatran is preferred to warfarin for stroke prevention in most patient
groups.
AD - Department of Cardiac Sciences, University of Calgary and Libin
Cardiovascular Institute of Alberta, Calgary, Alberta, Canada. amgillis@ucalgary.ca
AN - 21329856
AU - Gillis, A. M.
AU - Skanes, A. C.
DA - Jan-Feb
DO - 10.1016/j.cjca.2010.11.009
DP - NLM
ET - 2011/02/19
IS - 1
KW - Amiodarone/adverse effects/analogs & derivatives/therapeutic use
Anti-Arrhythmia Agents/adverse effects/therapeutic use
Atrial Fibrillation/classification/etiology/physiopathology/*therapy
Benzimidazoles/adverse effects/therapeutic use
*Cross-Cultural Comparison
Dabigatran
Dronedarone
Europe
Heart Rate/drug effects/physiology
Humans
North America
*Practice Guidelines as Topic
beta-Alanine/adverse effects/analogs & derivatives/therapeutic use
LA - eng
N1 - 1916-7075
Gillis, Anne M
Skanes, Allan C
Comparative Study
Journal Article
England
Can J Cardiol. 2011 Jan-Feb;27(1):7-13. doi: 10.1016/j.cjca.2010.11.009.
PY - 2011
SN - 0828-282x
SP - 7-13
ST - Comparing the 2010 North American and European atrial fibrillation guidelines
T2 - Can J Cardiol
TI - Comparing the 2010 North American and European atrial fibrillation guidelines
VL - 27
ID - 2718
ER -
TY - JOUR
AB - Timothy syndrome (TS) is an autosomal dominant condition with the
constellation of features including prolonged QT interval, hand and foot
abnormalities, and mental retardation or autism. Splawski et al. [2004] previously
described two phenotypes associated with TS distinguished by two unique and
different mutations within the CACNA1C gene. We report on a newborn who presented
with prolonged QT interval and associated polymorphic ventricular tachycardia,
dysmorphic facial features, syndactyly of the hands and feet, and joint
contractures, suggestive of TS. He developed a stroke, subsequent intractable
seizures, and was found to have cortical blindness and later profound developmental
delay. Initial targeted mutation analysis did not identify either of the previously
described TS associated mutations; however, full gene sequencing detected a novel
CACNA1C gene mutation (p.Ala1473Gly). The clinical and genetic findings in our case
expand both the clinical and molecular knowledge of TS.
AD - Maritime Medical Genetics Services, IWK Health Centre, Dalhousie University,
Halifax, Nova Scotia, Canada.
AN - 22106044
AU - Gillis, J.
AU - Burashnikov, E.
AU - Antzelevitch, C.
AU - Blaser, S.
AU - Gross, G.
AU - Turner, L.
AU - Babul-Hirji, R.
AU - Chitayat, D.
C2 - PMC3319791
C6 - NIHMS328805
DA - Jan
DO - 10.1002/ajmg.a.34355
DP - NLM
ET - 2011/11/23
IS - 1
J2 - American journal of medical genetics. Part A
KW - Autistic Disorder
Calcium Channels, L-Type/*genetics
Chromosome Mapping
Chromosomes, Human, Pair 12
Contracture/*genetics
Follow-Up Studies
Humans
Infant, Newborn
Long QT Syndrome/*genetics
*Mutation
Salicylic Acid/therapeutic use
Stroke/*genetics
Syndactyly/*genetics
LA - eng
N1 - 1552-4833
Gillis, Jane
Burashnikov, Elena
Antzelevitch, Charles
Blaser, Susan
Gross, Gil
Turner, Lesley
Babul-Hirji, Riyana
Chitayat, David
R01 HL047678-18/HL/NHLBI NIH HHS/United States
Case Reports
Journal Article
Am J Med Genet A. 2012 Jan;158A(1):182-7. doi: 10.1002/ajmg.a.34355. Epub 2011 Nov
21.
PY - 2012
SN - 1552-4825 (Print)
1552-4825
SP - 182-7
ST - Long QT, syndactyly, joint contractures, stroke and novel CACNA1C mutation:
expanding the spectrum of Timothy syndrome
T2 - Am J Med Genet A
TI - Long QT, syndactyly, joint contractures, stroke and novel CACNA1C mutation:
expanding the spectrum of Timothy syndrome
VL - 158a
ID - 2794
ER -
TY - JOUR
AB - INTRODUCTION AND OBJECTIVE: We present two families with atrial fibrillation
in 20 of 50 members, during three generations, with known cardiac rhythms, in order
to communicate their infrequent existence and the most relevant clinical facts.
METHOD: Clinical situation, evolution, ECG and ECHO findings, treatments and
complications related with the disease are investigated. RESULTS: The presence of
atrial fibrillation in 20 members is demonstrated, although one of them was on
sinus rhythm at the time of the study; 3 patients had left ventricular enlargement
on the ECHO study; the clinical situation was good in all patients except two who
died because of complications related to the arrythmia and a third patient that had
a brain stroke. The patients received different treatments because they where
controlled by different physicians; the possible lethal proarrythmic effect in such
cases must be taken into account. CONCLUSION: Familiar atrial fibrillation is a
very infrequent arrythmia, usually well tolerated, that follows a dominant
autosomic hereditary pattern. The use of antiagregants is advised because of the
risk of embolism, or the use of anticoagulants in the presence of associated risk
factors. Electric cardioversion has been show not be useful. The possible
proarrythmic effect of some antiarrythmic agents, used in the control of cardiac
frequency, must be taken into account.
AD - Unidad de Cardiología Pediátrica, Hospital Universitari Materno-Infantil Vall
d'Hebron, Barcelona.
AN - 9340695
AU - Girona, J.
AU - Domingo, A.
AU - Albert, D.
AU - Casaldàliga, J.
AU - Mont, L.
AU - Brugada, J.
AU - Brugada, R.
DA - Aug
DO - 10.1016/s0300-8932(97)73262-7
DP - NLM
ET - 1997/08/01
IS - 8
KW - Adolescent
Adult
Aged
Atenolol/therapeutic use
Atrial Fibrillation/diagnosis/drug therapy/*genetics
Echocardiography
Electrocardiography
Female
Humans
Male
Middle Aged
Pedigree
Propafenone/therapeutic use
LA - spa
N1 - Girona, J
Domingo, A
Albert, D
Casaldàliga, J
Mont, L
Brugada, J
Brugada, R
English Abstract
Journal Article
Spain
Rev Esp Cardiol. 1997 Aug;50(8):548-51. doi: 10.1016/s0300-8932(97)73262-7.
OP - Fibrilación auricular familiar.
PY - 1997
SN - 0300-8932 (Print)
0300-8932
SP - 548-51
ST - [Familial auricular fibrillation]
TI - [Familial auricular fibrillation]
VL - 50
ID - 2598
ER -
TY - JOUR
AB - A 43-year-old woman with a long history of heavy cigarette smoking was in
good health until she developed fatigue, dyspnea on exertion, and paroxysmal
nocturnal dyspnea approximately three months before admission to our hospital. Four
weeks before admission, she was admitted to another hospital for the sudden onset
of a right hemiparesis. She was noted to be in atrial fibrillation, and cardiac
catheterization and angiocardiography revealed triple-vessel coronary arterial
disease and moderately severe mitral regurgitation. Because of repeated episodes of
paroxysmal nocturnal dyspnea, she was referred to our hospital for cardiac surgery.
On admission, an electrocardiogram was recorded (Figure).
AD - Louisiana State University Health Sciences Center, New Orleans, USA.
AN - 23437451
AU - Glancy, D. L.
AU - Atluri, P.
AU - Heck, H.
AU - Duet, J.
AU - Ehsan, K.
AU - Jaligam, V.
AU - Helmcke, F.
DA - Nov-Dec
DP - NLM
ET - 2013/02/26
IS - 6
J2 - The Journal of the Louisiana State Medical Society : official organ of the
Louisiana State Medical Society
KW - Adult
Atrial Fibrillation/complications/*diagnosis/surgery
Dyspnea, Paroxysmal/complications
Female
Humans
Mitral Valve Insufficiency/complications
Stroke/etiology
LA - eng
N1 - Glancy, D Luke
Atluri, Prashanthi
Heck, Herman
Duet, Jess
Ehsan, Kian
Jaligam, Vijayendra
Helmcke, Frederick
Case Reports
Journal Article
United States
J La State Med Soc. 2012 Nov-Dec;164(6):343-5.
PY - 2012
SN - 0024-6921 (Print)
0024-6921
SP - 343-5
ST - ECG of the month. Cardiac failure and stroke in a 43-year-old woman. Coarse
atrial fibrillation indicating left atrial enlargement and left ventricular
hypertrophy with repolarization abnormality
T2 - J La State Med Soc
TI - ECG of the month. Cardiac failure and stroke in a 43-year-old woman. Coarse
atrial fibrillation indicating left atrial enlargement and left ventricular
hypertrophy with repolarization abnormality
VL - 164
ID - 2641
ER -
TY - JOUR
AB - Atrial fibrillation occurred in 16 (10%) of 167 patients with idiopathic
hypertrophic subaortic stenosis. The clinical and haemodynamic findings in these 16
patients are presented. Atrial fibrillation appeared late in the course of the
disease, and its occurrence did not seem to be related to the severity of left
ventricular outflow obstruction or to the amount of associated mitral
regurgitation. In each patient the onset of the arrhythmia was accompanied by
severe clinical deterioration, which often necessitated urgent medical treatment.
Digitalis was administered to all 16 patients with subsequent clinical improvement
in 15. Electrical cardioversion was uniformly successful in restoring sinus rhythm,
but atrial fibrillation usually recurred. In each of 8 patients catheterized during
atrial fibrillation, cardiac output was strikingly low (average, 1.9 l./min./m.
(2)), whereas it was normal in 10 of 13 patients studied in sinus rhythm. The
duration of follow-up from the onset of atrial fibrillation has averaged 5 years,
and 3 of the 16 patients have died of causes related to their heart disease. Four
have suffered cerebral emboli. Only 5 patients are now in stable sinus rhythm; in
general, they are less symptomatic than the patients in whom atrial fibrillation
has recurred.The unusually severe clinical deterioration at the onset of atrial
fibrillation and the low cardiac output measured during catheterization are thought
to be related to the loss of the important contribution to ventricular filling of
atrial systole in patients with poorly compliant ventricles, and to the effect of
an irregular ventricular rhythm on the variable nature of the outflow obstruction.
AN - 5528380
AU - Glancy, D. L.
AU - O'Brien, K. P.
AU - Gold, H. K.
AU - Epstein, S. E.
C2 - PMC487387
DA - Sep
DO - 10.1136/hrt.32.5.652
DP - NLM
ET - 1970/09/01
IS - 5
KW - Adolescent
Adult
Aortic Valve
Atrial Fibrillation/*etiology/therapy
Cardiac Output
Cardiomyopathy, Hypertrophic/*complications
Digitalis Glycosides/therapeutic use
Female
Humans
Intracranial Embolism and Thrombosis/complications
Male
Middle Aged
LA - eng
N1 - Glancy, D L
O'Brien, K P
Gold, H K
Epstein, S E
Journal Article
Br Heart J. 1970 Sep;32(5):652-9. doi: 10.1136/hrt.32.5.652.
PY - 1970
SN - 0007-0769 (Print)
0007-0769
SP - 652-9
ST - Atrial fibrillation in patients with idiopathic hypertrophic subaortic
stenosis
T2 - Br Heart J
TI - Atrial fibrillation in patients with idiopathic hypertrophic subaortic
stenosis
VL - 32
ID - 2829
ER -
TY - JOUR
AB - The initial therapy of atrial fibrillation is guided by the clinical
symptomatology of the patient. Acute atrial fibrillation at a rapid ventricular
rate is an emergency situation. Pharmacological therapy is aimed to delay
atrioventricular conduction and thereby slow the ventricular rate. A new and
interesting therapeutical option to induce conversion to sinus rhythm is the
intravenous administration of class-Ic drugs. The conversion rate of patients with
nonvalvular atrial fibrillation of recent onset is high and accounts up to 90%.
Patients with atrial fibrillation have an increased incidence of ischemic stroke.
Anticoagulation, i.e. administration of aspirin in patients under 70 years of age,
can reduce the occurrence of cerebral ischemic event.
AD - Klinik im Schachen, Aarau.
AN - 1519181
AU - Gloor, H. O.
DA - Aug
DP - NLM
ET - 1992/08/01
IS - 8
J2 - Therapeutische Umschau. Revue therapeutique
KW - Anti-Arrhythmia Agents/*therapeutic use
Atrial Fibrillation/*drug therapy/physiopathology
Atrioventricular Node/drug effects/physiopathology
Cerebral Infarction/physiopathology/prevention & control
Electrocardiography/drug effects
Humans
LA - ger
N1 - Gloor, H O
English Abstract
Journal Article
Review
Switzerland
Ther Umsch. 1992 Aug;49(8):531-5.
OP - Medikamente bei Vorhofflimmern.
PY - 1992
SN - 0040-5930 (Print)
0040-5930
SP - 531-5
ST - [Drugs in atrial fibrillation]
T2 - Ther Umsch
TI - [Drugs in atrial fibrillation]
VL - 49
ID - 2697
ER -
TY - JOUR
AB - OBJECTIVES: The aim of CATS (Cardiotoxicity of Adjuvant Trastuzumab Study)
was to prospectively assess clinical, biochemical, and genomic predictors of
trastuzumab-related cardiotoxicity (TRC). BACKGROUND: Cardiac dysfunction is a
common adverse effect of trastuzumab. Studies to identify predictive biomarkers for
TRC have enrolled heterogeneous populations and yielded mixed results. METHODS: A
total of 222 patients with early-stage human epidermal growth factor receptor 2-
positive breast cancer scheduled to receive adjuvant anthracyclines followed by
12 months of trastuzumab were prospectively recruited from 17 centers. Left
ventricular ejection fraction (LVEF), troponin T, and N-terminal prohormone of
brain natriuretic peptide were measured at baseline, post-anthracycline, and every
3 months during trastuzumab. Germline single-nucleotide polymorphisms in ERBB2,
FCGR2A, and FCGR3A were analyzed. TRC was defined as symptomatic heart failure;
cardiac death, arrhythmia, or infarction; a decrease in LVEF of >15% from baseline;
or a decrease in LVEF of >10% to <50%. RESULTS: TRC occurred in 18 of 217 subjects
(8.3%). Lower pre-anthracycline LVEF and greater interval decline in LVEF from pre-
to post-anthracycline were each associated with TRC on multivariate analyses (odds
ratio: 3.9 [p = 0.0001] and 7.9 [p < 0.0001] for a 5% absolute change in LVEF).
Higher post-anthracycline N-terminal prohormone of brain natriuretic peptide level
was associated with TRC on univariate but not multivariate analyses. There were no
associations between troponin T or ERBB2/FGCR polymorphisms and TRC. Baseline LVEF
and LVEF change post-anthracycline were used to generate a "low-risk TRC score" to
identify patients with low TRC incidence. CONCLUSIONS: Low baseline LVEF and
greater LVEF decline post-anthracycline were both independent predictors of TRC.
The other biomarkers did not further improve the ability to predict TRC.
(Cardiotoxicity of Adjuvant Trastuzumab [CATS]; NCT00858039).
AD - Department of Medical Oncology, Dana-Farber Cancer Institute, Boston,
Massachusetts; Department of Medical Oncology, Chris O'Brien Lifehouse, Sydney,
Australia; Peter MacCallum Cancer Centre, Melbourne, Australia; Sir Peter MacCallum
Department of Oncology, University of Melbourne, Melbourne, Australia. Electronic
address: shom.goel@petermac.org.
Department of Medical Oncology, Chris O'Brien Lifehouse, Sydney, Australia.
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston,
Massachusetts.
Barwon Health Cancer Services, Andrew Love Cancer Centre, Geelong, Australia.
St. George Cancer Care Centre, St. George Hospital, Sydney, Australia; Department
of Medical Oncology, Sutherland Hospital, Sydney, Australia.
St. George Cancer Care Centre, St. George Hospital, Sydney, Australia.
Macarthur Cancer Therapy Centre, Liverpool Hospital, Sydney, Australia.
Concord Cancer Centre, Concord Repatriation General Hospital, Sydney, Australia.
The Tweed Hospital, Tweed Heads & Griffith University, Gold Coast, Australia.
Northern Haematology and Oncology Group, San Integrated Cancer Centre, Sydney,
Australia.
Bankstown Cancer Centre, Bankstown Hospital, Sydney, Australia.
Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, Australia.
AN - 31401102
AU - Goel, S.
AU - Liu, J.
AU - Guo, H.
AU - Barry, W.
AU - Bell, R.
AU - Murray, B.
AU - Lynch, J.
AU - Bastick, P.
AU - Chantrill, L.
AU - Kiely, B. E.
AU - Abdi, E.
AU - Rutovitz, J.
AU - Asghari, R.
AU - Sullivan, A.
AU - Harrison, M.
AU - Kohonen-Corish, M.
AU - Beith, J.
DA - Sep
DO - 10.1016/j.jchf.2019.04.014
DP - NLM
ET - 2019/08/12
IS - 9
J2 - JACC. Heart failure
KW - *biomarkers
*breast cancer
*cardiotoxicity
*supportive care
*trastuzumab
LA - eng
N1 - 2213-1787
Goel, Shom
Liu, Jia
Guo, Hao
Barry, William
Bell, Richard
Murray, Bronwyn
Lynch, Jodi
Bastick, Patricia
Chantrill, Lorraine
Kiely, Belinda E
Abdi, Ehtesham
Rutovitz, Josie
Asghari, Ray
Sullivan, Anne
Harrison, Michelle
Kohonen-Corish, Maija
Beith, Jane
Journal Article
United States
JACC Heart Fail. 2019 Sep;7(9):795-804. doi: 10.1016/j.jchf.2019.04.014. Epub 2019
Aug 7.
PY - 2019
SN - 2213-1779
SP - 795-804
ST - Decline in Left Ventricular Ejection Fraction Following Anthracyclines
Predicts Trastuzumab Cardiotoxicity
T2 - JACC Heart Fail
TI - Decline in Left Ventricular Ejection Fraction Following Anthracyclines
Predicts Trastuzumab Cardiotoxicity
VL - 7
ID - 3108
ER -
TY - JOUR
AB - Continuous electrocardiographic (ECG) records were made over 24 hours in 130
ambulant outpatients complaining of syncope, dizzy turns, or palpitation. In all
these patients resting ECGs had failed to show significant dysrhythmias. Exercise
testing was performed on 64 patients and also failed to reveal any dysrhythmias.
Analysis of the tape recordings, however, showed appreciable dysrhythmias in 74% of
the group. In most cases the dysrhythmias were complex mixtures of rapid
supraventricular and ventricular rhythms. bouts of ventricular tachycardia were
seen in seven patients, all of whom were women. Episodic complete heart block was
seen in only two patients, but prolonged ventricular gaps (greater than 1-5 s), not
associated with ectopic beats, were found in 26. No episodes of ventricular
fibrillation were recorded. We conclude that many patients with vague symptoms
suggestive of transient cerebral ischaemia or irregular heart action have
significant and often dangerous dysrhythmias which can be diagnosed only by long-
term recording of the ECG under fully ambulant conditions.
AN - 1203673
AU - Goldberg, A. D.
AU - Raftery, E. B.
AU - Cashman, P. M.
C2 - PMC1675919
DA - Dec 6
DO - 10.1136/bmj.4.5996.569
DP - NLM
ET - 1975/12/06
IS - 5996
J2 - British medical journal
KW - Adolescent
Adult
Aged
*Electrocardiography/methods
Exercise Test
Female
Humans
Male
Middle Aged
Tape Recording
Time Factors
LA - eng
N1 - Goldberg, A D
Raftery, E B
Cashman, P M
Journal Article
Br Med J. 1975 Dec 6;4(5996):569-71. doi: 10.1136/bmj.4.5996.569.
PY - 1975
SN - 0007-1447 (Print)
0007-1447
SP - 569-71
ST - Ambulatory electrocardiographic records in patients with transient cerebral
attacks or palpitation
T2 - Br Med J
TI - Ambulatory electrocardiographic records in patients with transient cerebral
attacks or palpitation
VL - 4
ID - 2653
ER -
TY - JOUR
AB - The author reviewed electrocardiographic records of 150 patients with acute
stroke and 150 age- and sex-matched controls, to assess the relative frequencies of
ECG abnormalities among the pathophysiologic categories of stroke, and to
distinguish new abnormalities at the time of the stroke from those noted on prior
tracings. Of the 150 patients with stroke, 138 (92%) showed ECG abnormalities. The
most common abnormalities were also changes from prior tracings: QT prolongation
(68 patients, 45%), ischemic changes (59, 35%), U waves (42, 28%), tachycardia (42,
28%), and arrhythmias (41, 27%). Patients with cerebral embolus had a significantly
increased frequency of atrial fibrillation (9 patients, 47%); and with subarachnoid
hemorrhage an increased frequency of QT prolongation (20, 71%) and sinus arrhythmia
(5, 18%). The frequencies of QT prolongation and ischemic changes related strongly
to admission systolic pressure but not to mortality. Stroke patients had an
increased frequency of pathologic Q waves (30 patients, 20%) and left ventricular
hypertrophy (39, 26%), but these were not new findings at the time of the stroke.
The results are consistent with an interaction of underlying hypertensive or
atherosclerotic cardiovascular disease, sympathetic hyperactivity, and possibly
myocardial necrosis, in producing ECG changes.
AN - 462510
AU - Goldstein, D. S.
DA - May-Jun
DO - 10.1161/01.str.10.3.253
DP - NLM
ET - 1979/05/01
IS - 3
J2 - Stroke
KW - Acute Disease
Adult
Aged
Arrhythmias, Cardiac/physiopathology
Brain Ischemia/physiopathology
Cerebral Hemorrhage/physiopathology
Cerebrovascular Disorders/mortality/*physiopathology
Female
Heart Conduction System/physiopathology
Humans
Hypertension/physiopathology
Intracranial Embolism and Thrombosis/physiopathology
Male
Middle Aged
Myocardial Infarction/physiopathology
Prognosis
Subarachnoid Hemorrhage/physiopathology
LA - eng
N1 - Goldstein, D S
Journal Article
United States
Stroke. 1979 May-Jun;10(3):253-9. doi: 10.1161/01.str.10.3.253.
PY - 1979
SN - 0039-2499 (Print)
0039-2499
SP - 253-9
ST - The electrocardiogram in stroke: relationship to pathophysiological type and
comparison with prior tracings
T2 - Stroke
TI - The electrocardiogram in stroke: relationship to pathophysiological type and
comparison with prior tracings
VL - 10
ID - 2936
ER -
TY - JOUR
AB - Resuscitated victims of cardiac arrest with coronary heart disease represent
a group of patients with an accelerated mortality rate. Among 227 such patients in
our follow-up study, 20% had died at 1 year and 50% were dead in slightly over 3
years. Predictors of death were related to use of digitalis, elevated blood urea
nitrogen, cerebral vascular accident, previous myocardial infarction, and age. In a
subset of 103 patients in whom ambulatory electrocardiographic recordings were
available within 3 months of the arrest event, the presence of complexity and high-
frequency ventricular premature beats (VPBs) (greater than or equal to 25/hr) were
added to the mortality predictors of digitalis and diuretic therapy and elevated
blood urea nitrogen. An almost equal number of patients died suddenly and
nonsuddenly. Predictors of sudden death were treatment with quinidine and paired
VPBs. Occurrence of arrhythmias was an important addition to the previous mortality
predictors related to left ventricular dysfunction.
AN - 3986977
AU - Goldstein, S.
AU - Landis, J. R.
AU - Leighton, R.
AU - Ritter, G.
AU - Vasu, C. M.
AU - Wolfe, R. A.
AU - Acheson, A.
AU - VanderBrug Medendorp, S.
DA - May
DO - 10.1161/01.cir.71.5.873
DP - NLM
ET - 1985/05/01
IS - 5
J2 - Circulation
Ambulatory Care
Death, Sudden/etiology
Electrocardiography
Emergencies
Female
Follow-Up Studies
Heart Arrest/etiology/mortality/*therapy
Humans
Male
Models, Biological
*Resuscitation
Risk
LA - eng
N1 - Goldstein, S
Landis, J R
Leighton, R
Ritter, G
Vasu, C M
Wolfe, R A
Acheson, A
VanderBrug Medendorp, S
HL188000-09/HL/NHLBI NIH HHS/United States
Journal Article
United States
Circulation. 1985 May;71(5):873-80. doi: 10.1161/01.cir.71.5.873.
PY - 1985
SN - 0009-7322 (Print)
0009-7322
SP - 873-80
ST - Predictive survival models for resuscitated victims of out-of-hospital
cardiac arrest with coronary heart disease
T2 - Circulation
TI - Predictive survival models for resuscitated victims of out-of-hospital
cardiac arrest with coronary heart disease
VL - 71
ID - 2897
ER -
TY - JOUR
AB - The management of atrial fibrillation involves control of the ventricular
response rate, anticoagulation to reduce the risk of stroke and attempts to
maintain sinus rhythm. The approach to patients with atrial fibrillation has become
increasingly complex as therapeutic options have expanded. The ultimate reasons to
treat atrial fibrillation include improvement in symptoms, reduction in adverse
outcomes and improvement in survival. Despite increasing interest in non
pharmacological approaches to treat and potentially cure atrial fibrillation, drugs
remain the primary method to treat most patients. This review updates the present
state-of-the-art regarding medical management of atrial fibrillation based on
present and emerging evidence.
AD - Division of Cardiovascular Medicine, University of Iowa Hospitals, Iowa City,
Iowa 52242, USA.
AN - 19546032
AU - Gopinathannair, R.
AU - Sullivan, R. M.
AU - Olshansky, B.
DA - Aug
DO - 10.1016/j.hrthm.2009.02.013
DP - NLM
ET - 2009/06/24
IS - 8 Suppl
J2 - Heart rhythm
Atrial Fibrillation/complications/*therapy
Heart Rate
Humans
LA - eng
N1 - 1556-3871
Gopinathannair, Rakesh
Sullivan, Renee M
Olshansky, Brian
Journal Article
Review
United States
Heart Rhythm. 2009 Aug;6(8 Suppl):S17-22. doi: 10.1016/j.hrthm.2009.02.013. Epub
2009 Feb 12.
PY - 2009
SN - 1547-5271
SP - S17-22
ST - Update on medical management of atrial fibrillation in the modern era
T2 - Heart Rhythm
TI - Update on medical management of atrial fibrillation in the modern era
VL - 6
ID - 2738
ER -
TY - JOUR
AB - BACKGROUND: Hypertension, due to its prevalence, is a common and independent
risk factor for atrial fibrillation (AF). High blood pressure causes structural and
functional changes in the myocardium, leading to an increased risk of arrhythmia.
This risk is higher when hypertension is accompanied by concomitant diseases that
contribute to the development of AF. AIM: To estimate prevalence of AF and
predisposing factors for AF in patients with hypertension hospitalised in our
cardiology unit. METHODS: This retrospective analysis included 4459 patients
hospitalised in the Clinical Department of Cardiology in 2009-2010. Hypertension
was identified in 2512 (56.3%) patients. The study group consisted of 685 (27.3%)
patients with hypertension and concomitant AF, and the control group included 1827
(63.7%) hypertensive patients without AF. We analysed clinical data including AF
type, coexisting diseases and left ventricular ejection fraction evaluated by
echocardiography. RESULTS: Mean patient age in the study group was 74 years
compared to 67 years in the control group. Most patients in the study group had
either paroxysmal (46%) or permanent AF (45.5%). The following rates of coexisting
diseases were found in the study and control groups: heart failure (HF) 54.3% vs.
31.4%, respectively (p < 0.001), ischaemic heart disease (IHD) 44.4% vs. 25.2% (p <
0.001), diabetes 28.3% vs. 24.2% (p = 0.126), hypercholesterolaemia 25.4% vs. 30.4%
(p = 0.067), stroke 10% vs. 3% (p = 0.0028), hyperthyroidism 4.7% vs. 1.9% (p =
0.0002), hypothyroidism 5.1% vs. 2.1% (p = 0.0001), and euthyroid goitre 5.3% vs.
2.1% (p < 0.0001). Multivariate logistic regression analysis identified the
following factors that significantly affected the occurrence of AF in patients with
hypertension: hypothyroidism (hazard ratio [HR] 3.27), IHD (HR 2.75),
hyperthyroidism (HR 2.55), euthyroid goitre (HR 2.13), previous myocardial
infarction (HR 1.96), and HF (HR 1.66). CONCLUSIONS: Among hospitalised patients
with hypertension, AF is present in a significant proportion of patients.
Conditions predisposing to this arrhythmia in hypertensives include HF, IHD,
thyroid diseases, and previous myocardial infarction. There was no evidence that
diabetes, abnormal lipid profile, and impaired kidney function affected AF rate
among patients with hypertension.
AD - 1st Clinical Department of Cardiology, Swietokrzyskie Centre of Cardiology,
Kielce. iwona.gorczyca@interia.pl
AN - 23788340
AU - Gorczyca-Michta, I.
AU - Wożakowska-Kapłon, B.
AU - Tomasik, E.
DO - 10.5603/kp.2013.0062
DP - NLM
ET - 2013/06/22
IS - 4
J2 - Kardiologia polska
KW - Aged
Causality
Comorbidity
Female
Humans
Hypercholesterolemia/epidemiology
Hypertension/*epidemiology
Hyperthyroidism/epidemiology
Logistic Models
Male
Prevalence
Risk Factors
Stroke/epidemiology
LA - eng
N1 - 1897-4279
Gorczyca-Michta, Iwona
Wożakowska-Kapłon, Beata
Tomasik, Ewa
Journal Article
Poland
Kardiol Pol. 2013;71(4):352-8. doi: 10.5603/KP.2013.0062.
PY - 2013
SN - 0022-9032
SP - 352-8
ST - Prevalence and predisposing conditions for atrial fibrillation in
hospitalised patients with hypertension
T2 - Kardiol Pol
TI - Prevalence and predisposing conditions for atrial fibrillation in
hospitalised patients with hypertension
VL - 71
ID - 2552
ER -
TY - JOUR
AB - Endocrine disorders are associated with various tachyarrhythmias, including
atrial fibrillation (AF), ventricular tachycardia (VT), ventricular fibrillation
(VF), and bradyarrhythmias. Along with underlying arrhythmia substrate, electrolyte
disturbances, glucose, and hormone levels, accompanying endocrine disorders
contribute to development of arrhythmia. Arrhythmias may be life-threatening,
facilitate cardiogenic shock development and increase mortality. The knowledge on
the incidence of tachy- and bradyarrhythmias, clinical and prognostic significance
as well as their management is limited; it is represented in observational studies
and mostly in case reports on management of challenging cases. It should be also
emphasized, that the topic is not covered in detail in current guidelines.
Therefore, cardiologists and multidisciplinary teams participating in care of such
patients do need the evidence-based, or in case of limited evidence expert-opinion
based recommendations, how to treat arrhythmias using contemporary approaches,
prevent their complications and recurrence in patients with endocrine disorders. In
recognizing this close relationship between endocrine disorders and arrhythmias,
the European Heart Rhythm Association (EHRA) convened a Task Force, with
representation from Asia-Pacific Heart Rhythm Society (APHRS) and Sociedad
Latinoamericana de Estimulación Cardíaca y Electrofisiología (SOLAECE), with the
remit of comprehensively reviewing the available evidence and publishing a joint
consensus document on endocrine disorders and cardiac arrhythmias, and providing
up-to-date consensus recommendations for use in clinical practice.
AD - Eskisehir Osmangazi University, Eskisehir, Turkey.
Cardiology Division, Department of Diagnostics, Clinical and Public Health
Medicine, University of Modena and Reggio Emilia, Policlinico di Modena, Modena,
Italy.
University of Medicine and Pharmacy "Carol Davila", Colentina University Hospital,
Bucharest, Romania.
Centre Hospitalier Universitaire Trousseau et Université François Rabelais, Tours,
France.
Hospital Israelita Albert Einstein, São Paulo, Brazil.
Renmin Hospital of Wuhan University, Wuhan, China.
Adana, Turkey.
Center for Postgraduate Education and Research, Bishkek, Kyrgyzstan.
Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK.
Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg
University, Aalborg, Denmark.
The University of Adelaide, Lyell McEwin Hospital, Royal Adelaide Hospital and
SAHMRI, Adelaide, Australia.
School of Medicine, Belgrade University; Cardiology Clinic, Clinical Centre of
Serbia, Belgrade, Serbia.
Clinica CardioVid, Medellín, Antioquia, Colombia.
Umc Utrecht, Utrecht, Netherlands.
HU Virgen de la Arrixaca, Murcia, Spain.
AN - 29566135
AU - Gorenek, B.
AU - Boriani, G.
AU - Dan, G. A.
AU - Fauchier, L.
AU - Fenelon, G.
AU - Huang, H.
AU - Kudaiberdieva, G.
AU - Lip, G. Y. H.
AU - Mahajan, R.
AU - Potpara, T.
AU - Ramirez, J. D.
AU - Vos, M. A.
AU - Marin, F.
DA - Jun 1
DO - 10.1093/europace/euy051
DP - NLM
ET - 2018/03/23
IS - 6
KW - *Arrhythmias, Cardiac/complications/diagnosis/epidemiology/therapy
Comorbidity
Consensus
*Endocrine System Diseases/classification/epidemiology
Global Health
Humans
Patient Care Management/*methods
Prognosis
Risk Assessment
LA - eng
N1 - 1532-2092
Gorenek, Bulent
Boriani, Giuseppe
Dan, Gheorge-Andrei
Fauchier, Laurent
Fenelon, Guilherme
Huang, He
Kudaiberdieva, Gulmira
Lip, Gregory Y H
Mahajan, Rajiv
Potpara, Tatjana
Ramirez, Juan David
Vos, Marc A
Marin, Francisco
ESC Scientific Document Group
Journal Article
England
Europace. 2018 Jun 1;20(6):895-896. doi: 10.1093/europace/euy051.
PY - 2018
SN - 1099-5129
SP - 895-896
ST - European Heart Rhythm Association (EHRA) position paper on arrhythmia
management and device therapies in endocrine disorders, endorsed by Asia Pacific
Heart Rhythm Society (APHRS) and Latin American Heart Rhythm Society (LAHRS)
T2 - Europace
TI - European Heart Rhythm Association (EHRA) position paper on arrhythmia
management and device therapies in endocrine disorders, endorsed by Asia Pacific
Heart Rhythm Society (APHRS) and Latin American Heart Rhythm Society (LAHRS)
VL - 20
ID - 2319
ER -
TY - JOUR
AB - Previous TIA or stroke, diabetes, advanced age, impaired left ventricular
function, and a history of hypertension are strong risk factors in patients with
nonvalvular AF. When none of these factors is present, aspirin in a dose of 325 mg
offers effective protection against future stroke. When any of these factors are
present, warfarin adjusted to an INR of 2.0 to 3.0 offers greater protection
against future stroke than aspirin alone or aspirin and fixed-dose warfarin (INR
1.2-1.5). More data are needed before newer anticoagulants can be recommended for
treatment.
AD - University of Minnesota, Minneapolis, USA. Gorni002@tc.umn.edu
AN - 10951751
AU - Gornick, C. C.
DA - Aug
DO - 10.3810/pgm.2000.08.1185
DP - NLM
ET - 2000/08/22
IS - 2
J2 - Postgraduate medicine
Humans
Risk Assessment
Risk Factors
Stroke/*etiology/*prevention & control
LA - eng
N1 - Gornick, C C
Journal Article
Review
England
Postgrad Med. 2000 Aug;108(2):113-6, 119-21, 125-6. doi: 10.3810/pgm.2000.08.1185.
PY - 2000
SN - 0032-5481 (Print)
0032-5481
SP - 113-6, 119-21, 125-6
ST - Anticoagulant use in nonvalvular atrial fibrillation. Determining risk and
choosing the safest course
T2 - Postgrad Med
TI - Anticoagulant use in nonvalvular atrial fibrillation. Determining risk and
choosing the safest course
VL - 108
ID - 2744
ER -
TY - JOUR
AB - Atrial fibrillation (AF) is the most common sustained arrhythmia. Its
prevalence is increasing and accordingly, so is its burden on healthcare systems
throughout the world. The pathophysiology of AF is complex and poorly understood,
which of itself presents a major challenge to the management of this important
condition. AF is associated with increased morbidity and mortality, particularly in
patients with underlying left ventricular dysfunction. Once AF occurs, it is often
difficult to 'cure' and as such, the major focus of therapy is currently divided
essentially between a rate control strategy and a need to revert to and maintain
sinus rhythm. Both approaches seek to minimise the associated symptoms and
complications. Over the past two decades, numerous pharmacological approaches to
the management of AF have been employed, many of which have been shown to be
relatively ineffective or confounded by major complications. Accordingly, recent
research and interest has focused on non-pharmacological electrophysiological
therapies to either cure AF or improve symptoms. This review summarises the current
approaches to the management AF and provides some new insights into emerging
therapies for this common clinical problem.
AD - Department of Cardiovascular Medicine, Alfred Hospital, Commercial Rd,
Melbourne 3004, Victoria, Australia. p.gould@alfred.org.au
AN - 14596645
AU - Gould, P. A.
AU - Power, J.
AU - Broughton, A.
AU - Kaye, D. M.
DA - Nov
DO - 10.1517/14656566.4.11.1889
DP - NLM
ET - 2003/11/05
IS - 11
J2 - Expert opinion on pharmacotherapy
Atrial Fibrillation/drug therapy/epidemiology/etiology/physiopathology/*therapy
Humans
LA - eng
N1 - Gould, Paul A
Power, John
Broughton, Archer
Kaye, David M
Journal Article
Review
England
Expert Opin Pharmacother. 2003 Nov;4(11):1889-99. doi: 10.1517/14656566.4.11.1889.
PY - 2003
SN - 1465-6566 (Print)
1465-6566
SP - 1889-99
ST - Review of the current management of atrial fibrillation
T2 - Expert Opin Pharmacother
TI - Review of the current management of atrial fibrillation
VL - 4
ID - 2556
ER -
TY - JOUR
AB - BACKGROUND: Atrial fibrillation (AF) is common in ST-segment elevation
myocardial infarction (STEMI), but its influence on prognosis remains
controversial. AIM: We examined the 1-year prognostic value of AF in STEMI,
distinguishing patients with prior AF from patients with de novo AF. METHODS:
Between January 2004 and December 2015, 3173 STEMI patients were enrolled in the
RIMA registry (Registre des Infarctus en Maine Anjou). They were divided into 3
groups: (1) AF-free patients; (2) patients with known prior AF; and (3) patients
with de novo AF during hospitalization (including admission). We defined 3 primary
outcomes at 1-year post-discharge: cardiovascular mortality, readmission for heart
failure (HF), and stroke. Temporal onset of de novo AF was also studied. RESULTS: A
total 158 patients (5%) had prior AF, and 278 (8.8%) presented de novo AF. Prior AF
patients were significantly older [81 (73;86) years] with more comorbidities, but
de novo AF patients presented with a greater creatine kinase peak and lower left
ventricular ejection fraction [LVEF=44 (35;50)% for de novo AF vs 50 (40;55)% for
prior AF, p<0.001]. At 1-year follow-up, cardiovascular mortality was higher in
cases of AF (13.5% for prior AF vs 9.2% for de novo AF, compared with 2.4% for AF-
free patients, p<0.001). After adjustments, only de novo AF was correlated with
cardiovascular mortality (hazard ratio 2.49; 95% CI 1.32-4.67; p=0.004), but both
types of AF were correlated with readmission for HF. There was no significant
difference in respect of stroke between prior AF, de novo AF, and AF-free (2.2%,
0.5%, and 0.8%, respectively, p=0.327). Finally, outcomes did not differ between AF
occurring <24h after admission (n=127) and de novo AF occurring within ≥24h
(n=151). CONCLUSION: De novo AF was independently associated with 1-year
cardiovascular mortality. It should not be considered as an intercurrent event of
STEMI, but rather as a strong prognostic marker.
AD - Institut MitoVasc, Université d'Angers, Service de Cardiologie, CHU d'Angers,
Angers, France.
Institut MitoVasc, Université d'Angers, Service de Cardiologie, CHU d'Angers,
Angers, France; Département de Médecine Physique et de Réadaptation, CHU Angers -
Les Capucins, Angers, France.
Institut Mutualiste de Montsouris, Paris, France.
Service de Cardiologie, Centre Hospitalier de Cholet, Cholet, France.
Angers, France; UMR CNRS 6015 - INSERM U1083, Angers, France.
Angers, France; UMR CNRS 6015 - INSERM U1083, Angers, France. Electronic address:
lobiere@chu-angers.fr.
AN - 31079915
AU - Gourronc, Y.
AU - Grall, S.
AU - Ingremeau, D.
AU - Desprets, L.
AU - Prunier, F.
AU - Furber, A.
AU - Bière, L.
DA - Aug
DO - 10.1016/j.jjcc.2019.02.004
DP - NLM
ET - 2019/05/14
IS - 2
KW - Aged
Atrial Fibrillation/complications/*mortality/physiopathology
Biomarkers/analysis
Female
Heart Failure/etiology/mortality
Humans
Male
Middle Aged
Patient Readmission/*statistics & numerical data
Prognosis
Registries
ST Elevation Myocardial Infarction/etiology/*mortality/physiopathology
*Stroke Volume
Atrial fibrillation
Outcomes
Registry
LA - eng
N1 - 1876-4738
Gourronc, Youna
Grall, Sylvain
Ingremeau, Delphine
Desprets, Laurent
Prunier, Fabrice
Furber, Alain
Bière, Loïc
Journal Article
Netherlands
J Cardiol. 2019 Aug;74(2):123-129. doi: 10.1016/j.jjcc.2019.02.004. Epub 2019 May
10.
PY - 2019
SN - 0914-5087
SP - 123-129
ST - De novo atrial fibrillation as an independent prognostic marker after ST-
segment elevation myocardial infarction: Results from the RIMA registry
T2 - J Cardiol
TI - De novo atrial fibrillation as an independent prognostic marker after ST-
segment elevation myocardial infarction: Results from the RIMA registry
VL - 74
ID - 2479
ER -
TY - JOUR
AB - Amiodarone is a highly effective antiarrhythmic agent used in life-
threatening ventricular and supraventricular arrhythmias. Its long-term use may
however lead to several adverse effects, including corneal deposits, liver and
thyroid gland dysfunction, lung lesions, bone marrow injury, skin lesions, or
neurological abnormalities. The article presents the case of a 56-year-old man with
a history of a stroke, who after a few days of amiodarone therapy for an episode of
atrial fibrillation was diagnosed with amiodarone-induced hyperthyroidism and
interstitial pulmonary lesions. Clinical and laboratory symptoms of hyperthyroidism
and radiographic signs of pulmonary involvement did not occur until several weeks
after discontinuation of amiodarone therapy. Differential diagnosis of causes of
hyperthyroidism and diseases causing nodular pulmonary lesions did not demonstrate
any other pathologies. Empirical antibiotic therapy and administration of
thiamazole and high doses of propranolol failed to improve the patient's clinical
status. It was not until thiamazole was given in combination with
glucocorticosteroids, when a slow relief of hyperthyroidism symptoms and resolution
of radiographic pulmonary signs were observed. Based on the presented case, the
risk of appearance of 2 serious concomitant adverse effects was demonstrated, even
following a short-term amiodarone therapy. This paper also contains an overview of
adverse effects which may be encountered during or after therapy with this
effective antiarrhythmic agent. It was emphasized how important it is to select
patients appropriately, and to monitor potential adverse effects during amiodarone
therapy.
AD - Chair and Department of internal Diseases, Pneumonology and Allergology,
Warsaw Medical University, Warszawa, Poland. mgrabczak@yahoo.com
AN - 18846989
AU - Grabczak, E. M.
AU - Zielonka, T. M.
AU - Wiwała, J.
AU - Bareła, A. D.
AU - Opuchlik, A.
AU - Potulska, A.
AU - Ambroziak, U.
AU - Chazan, R.
DA - Sep
DP - NLM
ET - 2008/10/14
IS - 9
J2 - Polskie Archiwum Medycyny Wewnetrznej
KW - Amiodarone/administration & dosage/*adverse effects
Anti-Arrhythmia Agents/administration & dosage/*adverse effects
Atrial Fibrillation/etiology/*therapy
Humans
Hyperthyroidism/*chemically induced/diagnosis
Lung Diseases, Interstitial/*chemically induced/diagnosis
Male
Middle Aged
Pulmonary Alveoli/drug effects
*Stroke Rehabilitation
LA - eng
N1 - Grabczak, Elzbieta Magdalena
Zielonka, Tadeusz M
Wiwała, Joanna
Bareła, Anna Dagmara
Opuchlik, Andrzej
Potulska, Anna
Ambroziak, Urszula
Chazan, Ryszarda
Case Reports
Journal Article
Poland
Pol Arch Med Wewn. 2008 Sep;118(9):524-9.
PY - 2008
SP - 524-9
ST - Amiodarone induced pneumonitis and hyperthyroidism: case report
T2 - Pol Arch Med Wewn
TI - Amiodarone induced pneumonitis and hyperthyroidism: case report
VL - 118
ID - 2687
ER -
TY - JOUR
AB - Thirty seven patients (mean age = 80.2 years with extremes from 66 to 98
years), presenting atrial fibrillation (AF), presumably idiopathic (non known heart
disease, completely normal cardiac auscultation, good quality chest X-ray and
electrocardiogram, no laboratory test anomaly), and paroxystic (n = 7: 19 p. cent)
or permanent (n = 30: 81 p. cent), were given an electrocardiogram TM and
bidimensional. In only 9 of them (24.3 p. cent), this examination is completely
normal. Three other patients (8.1 p. cent) present an isolated dilatation of the
left atrium. The 25 remaining patients present various cardiopericardic anomalies:
valvular pathologies (n = 2: 59.4 p. cent): mitral (n = 15: 40.5 p. cent) more
often than aortic (n = 7: 18.9 p. cent); myocardiopathies (n = 8: 21.6 p. cent),
hypertrophic (n = 2), dilated (n = 4) or hypertrophic and dilated (n = 2); moderate
pericardial effusion (n = 1: 2.7 p. cent). The mean left and right ventricular
diameters, measured in TM mode, are normal as well as the mean contractility
indexes (percentage of shortening of the small axis, stroke volume) and the mean
filling index (mitral gradient EF) of the LV. Overall, the transverse diameter of
the LA is moderately increased (41.9 +/- 9.7 mm); it is not significantly different
from the AF, either paroxystic (41.5 +/- 4.9 mm) or permanent (42 +/- 9.93 mm) and
whether it is (40.5 +/- 9.9 mm =) or not (42.5 +/- 8.8 mm) complicated by a
systemic embolism, especially cerebral. Therefore, the sonocardiogram demonstrates
a latent cardiopathy in two-thirds of the patients over 65 presenting a presumably
idiopathic AF.(ABSTRACT TRUNCATED AT 250 WORDS)
AD - Service de Cardiologie, Centre Hospitalier, Valence.
AN - 2317000
AU - Grand, A.
AU - Fichter, C.
AU - Ferry, M.
AU - Fichter, P.
AU - Pernot, F.
DA - Jan
DP - NLM
ET - 1990/01/01
IS - 1
J2 - Annales de cardiologie et d'angeiologie
KW - Aged
Aged, 80 and over
Aging/physiology
Atrial Fibrillation/*etiology
*Echocardiography
Female
Heart Diseases/diagnosis
Hospitalization
Humans
Male
LA - fre
N1 - Grand, A
Fichter, C
Ferry, M
Fichter, P
Pernot, F
English Abstract
Journal Article
France
Ann Cardiol Angeiol (Paris). 1990 Jan;39(1):7-12.
OP - Intérêt de l'échocardiographie chez les patients âgés atteints de
fibrillation auriculaire présumée idiopathique.
PY - 1990
SN - 0003-3928 (Print)
0003-3928
SP - 7-12
ST - [Value of echocardiography in aged patients with presumed idiopathic
auricular fibrillation]
T2 - Ann Cardiol Angeiol (Paris)
TI - [Value of echocardiography in aged patients with presumed idiopathic
auricular fibrillation]
VL - 39
ID - 2978
ER -
TY - JOUR
AB - OBJECTIVES: This study was an analysis of factors associated with stroke in a
population of patients paced for sinus node dysfunction in a large prospective
clinical trial (Mode Selection Trial [MOST]). BACKGROUND: The effects of dual-
chamber versus single-chamber ventricular pacing on subsequent stroke in patients
with sinus node dysfunction are not known. METHODS: A total of 2,010 patients with
sinus node dysfunction were randomized to ventricular or dual-chamber pacing and
followed for a median of 33.1 months. RESULTS: The median participant age was 74
years. During 5,664 patient-years of follow-up, 90 strokes (11 hemorrhagic)
occurred. By life-table analysis, the rate of stroke was 2.2% (95% confidence
interval [CI] 1.6 to 2.9) at one year and 5.8% (95% CI 4.5 to 7.1) at four years.
The incidence of stroke was not significantly different in dual-chamber (4%) as
compared with ventricular-paced patients (4.9%) (hazard ratio [HR] 0.82, 95% CI
0.54 to 1.25, p = 0.36). Multivariable analysis demonstrated that significant
predictors of stroke included prior stroke or transient ischemic attack, Caucasian
race, hypertension, prior systemic embolism, and New York Heart Association
functional class III or IV (p < 0.05); pacing mode remained non-significant after
adjustment for these factors (p = 0.37). Clinically reported atrial fibrillation
after implantation was a risk factor for stroke in this cohort after adjustment for
other predictors of stroke (p = 0.042, HR 1.68 [95% CI 1.02 to 2.76]). CONCLUSIONS:
Clinical characteristics, but not mode of pacing, were associated with subsequent
stroke in patients paced for sinus node dysfunction.
AD - Division of Cardiology, Jefferson Medical College and Thomas Jefferson
University Hospital, Philadelphia, Pennsylvania 19107, USA. greenspon@jefferson.edu
AN - 15120821
AU - Greenspon, A. J.
AU - Hart, R. G.
AU - Dawson, D.
AU - Silver, M.
AU - Flaker, G. C.
AU - Schron, E.
AU - Goldman, L.
AU - Lee, K. L.
AU - Lamas, G. A.
DA - May 5
DO - 10.1016/j.jacc.2003.09.067
DP - NLM
ET - 2004/05/04
IS - 9
KW - Age Factors
Aged
Aged, 80 and over
Female
Follow-Up Studies
Humans
Male
Prospective Studies
Risk Factors
Sick Sinus Syndrome/epidemiology/*therapy
Statistics as Topic
Treatment Outcome
LA - eng
N1 - Greenspon, Arnold J
Hart, Robert G
Dawson, David
Hellkamp, Anne S
Silver, Marc
Flaker, Greg C
Schron, Eleanor
Goldman, Lee
Lee, Kerry L
Lamas, Gervasio A
MOST Study Investigators
HL 53973/HL/NHLBI NIH HHS/United States
U01 HL 49804/HL/NHLBI NIH HHS/United States
Clinical Trial
Comparative Study
Journal Article
Multicenter Study
United States
J Am Coll Cardiol. 2004 May 5;43(9):1617-22. doi: 10.1016/j.jacc.2003.09.067.
PY - 2004
SN - 0735-1097 (Print)
0735-1097
SP - 1617-22
ST - Predictors of stroke in patients paced for sick sinus syndrome
TI - Predictors of stroke in patients paced for sick sinus syndrome
VL - 43
ID - 2577
ER -
TY - JOUR
AB - OBJECTIVES: Cardiac arrest (CA) in patients with acute myocardial infarction
is associated with a poor prognosis. Due to the additional trauma, risk of stroke
and lack of data, coronary artery bypass grafting (CABG) is a controversial
revascularization strategy for patients who cannot be treated percutaneously.
Against this background, we investigated the outcome of patients from our
department with acute myocardial infarction undergoing CABG after CA. METHODS:
Between January 2001 and January 2015, 129 patients with preoperative CA due to
acute myocardial infarction underwent CABG at our institution within 48 h after the
CA had occurred. Predictors of in-hospital and long-term mortality were analysed.
Neurological outcome according to cerebral performance category scale was
investigated. RESULTS: Sixty CA (47%) events occurred out-of-hospital. Ventricular
fibrillation was the major underlying arrhythmia ( n = 92, 71%). The mean age was
65 ± 10 years. Eighty-four patients (65%) were diagnosed with ST-elevation
myocardial infarction and 108 patients (84%) had 3-vessel coronary artery disease.
Forty-three cases (33%) underwent percutaneous transluminal angioplasty. The median
time to CABG was 4 (range 0.2-4) h. Complete revascularization was achieved in 106
patients (83%). The stroke rate was 9% ( n = 11) and hypoxic brain damage occurred
in 16 patients (12%). Nine subjects (7%) needed extracorporeal life support. Four
intraoperative deaths (3%) occurred; the 30-day mortality rate was 23% ( n = 30);
the mortality rate during follow-up was 30% ( n = 27). A total of 79% ( n = 70)
of patients discharged alive showed good neurological outcome according to the
cerebral performance category scale. CONCLUSIONS: Despite the reluctance to expose
patients with CA to early CABG, our data indicate that the operative strategy may
not be as unfavourable as suspected.
AD - Department of Cardiovascular Surgery, University Hospital of Schleswig-
Holstein, Campus Kiel, Kiel, Germany.
Department of Internal Medicine III, Cardiology and Angiology, University Hospital
of Schleswig-Holstein, Campus Kiel, DZHK (German Center for Cardiovascular Disease,
Partner Site Kiel/Hamburg/Lübeck), Kiel, Germany.
Department of Anaesthesiology and Intensive Care Medicine, Institute for Emergency
Medicine, University Hospital Schleswig-Holstein, Kiel, Germany.
AN - 28486696
AU - Grothusen, C.
AU - Friedrich, C.
AU - Attmann, T.
AU - Meinert, J.
AU - Ohnewald, E.
AU - Ulbricht, U.
AU - Huenges, K.
AU - Haneya, A.
AU - Frank, D.
AU - Graesner, J. T.
AU - Schoettler, J.
AU - Cremer, J.
DA - Aug 1
DO - 10.1093/ejcts/ezx112
DP - NLM
ET - 2017/05/10
IS - 2
KW - Aged
*Coronary Artery Bypass/mortality
Female
*Heart Arrest/etiology/surgery
Humans
Male
Middle Aged
Myocardial Infarction/*complications/surgery
Treatment Outcome
Acute myocardial infarction
Cardiac arrest
Coronary artery bypass surgery
LA - eng
N1 - 1873-734x
Grothusen, Christina
Friedrich, Christine
Attmann, Tim
Meinert, Jette
Ohnewald, Eva
Ulbricht, Ulysses
Huenges, Katharina
Haneya, Assad
Frank, Derk
Graesner, Jan-Thorsten
Schoettler, Jan
Cremer, Jochen
Journal Article
Germany
Eur J Cardiothorac Surg. 2017 Aug 1;52(2):297-302. doi: 10.1093/ejcts/ezx112.
PY - 2017
SN - 1010-7940
SP - 297-302
ST - Coronary artery bypass surgery within 48 hours after cardiac arrest due to
acute myocardial infarction
TI - Coronary artery bypass surgery within 48 hours after cardiac arrest due to
VL - 52
ID - 3093
ER -
TY - JOUR
AB - BACKGROUND: A neuroprotective drug may be safe and effective if given very
early and in combination with recombinant tissue-type plasminogen activator (rt-PA)
to acute stroke patients. No clinical trial has yet tested this hypothesis.
OBJECTIVE: To assess the feasibility, safety and efficacy of simultaneously
combining the neuroprotective drug lubeluzole with rt-PA. METHOD: Patients who
qualified for and received rt-PA within 3 h of symptom onset were randomly
allocated 1:1 to lubeluzole (7.5 mg i.v. over 1 h, then continuous 5-day infusion
of 10 mg/day) or placebo. Infusion of the study medication was started before the
end of the 1-hour rt-PA infusion. Inclusion criteria were the same as those of the
FDA-approved guidelines for rt-PA, plus National Institutes of Health Stroke Scale
(NIHSS) >5 and absence of serious ventricular arrhythmia, atrioventricular block or
Q-T >450 ms. EKG was continuously monitored until 48 h after treatment. The primary
outcomes were adverse events, especially hemorrhage and severe arrhythmia, and
functionality as determined by the Barthel Index divided into >70,0-70 and dead.
RESULTS: 89 patients were randomized at 34 centers over 8 months. The study was
terminated by the sponsor before the planned enrollment of 200 patients when a
concurrent phase 3 trial of lubeluzole versus placebo given up to 8 h after stroke
was negative. In our study, the mean NIHSS was 14.5, and the mean time from symptom
onset to rt-PA was 2.5 h and to randomization to lubeluzole or placebo 3.2 h.
Mortality was 26%, intracerebral hemorrhage occurred in 10% and serious adverse
events in 51%. There were no differences between the two treatment groups in any of
these variables, outcomes or in the Barthel Index or other measures of
functionality. CONCLUSION: Combining neuroprotective drugs such as lubeluzole
simultaneously with rt-PA is feasible and safe. The efficacy of this strategy,
using a potentially more effective neuroprotective agent, should be evaluated in an
adequately powered clinical trial.
AD - University of Texas-Houston Medical School, Houston, TX 77030, USA.
james.c.grotta@uth.tmc.edu
AN - 11641593
AU - Grotta, J.
DO - 10.1159/000047713
DP - NLM
ET - 2001/10/20
IS - 3
KW - Activities of Daily Living
Aged
Cerebral Hemorrhage/chemically induced
Double-Blind Method
Feasibility Studies
Female
Glasgow Coma Scale
Humans
Male
Neuroprotective Agents/adverse effects/*therapeutic use
Piperidines/adverse effects/*therapeutic use
Plasminogen Activators/adverse effects/*therapeutic use
Prospective Studies
Recombinant Proteins/adverse effects/therapeutic use
Stroke/*drug therapy/mortality/physiopathology
Thiazoles/adverse effects/*therapeutic use
Tissue Plasminogen Activator/adverse effects/*therapeutic use
LA - eng
N1 - Grotta, J
Combination Therapy Stroke Trial Investigators
Clinical Trial
Journal Article
Multicenter Study
Switzerland
Cerebrovasc Dis. 2001;12(3):258-63. doi: 10.1159/000047713.
PY - 2001
SN - 1015-9770 (Print)
1015-9770
SP - 258-63
ST - Combination Therapy Stroke Trial: recombinant tissue-type plasminogen
activator with/without lubeluzole
TI - Combination Therapy Stroke Trial: recombinant tissue-type plasminogen
activator with/without lubeluzole
VL - 12
ID - 2849
ER -
TY - JOUR
AB - Transcatheter aortic valve replacement is an increasingly common treatment of
critical aortic stenosis. Many aortic stenosis patients have concomitant left
ventricular dysfunction, which can instigate the formation of thrombus resistant to
anticoagulation. Recent trials evaluating transcatheter aortic valve replacement
have excluded patients with left ventricular thrombus. We present a case in which
an 86-year-old man with known left ventricular thrombus underwent successful
transcatheter aortic valve replacement under cerebral protection.
AD - Division of Cardiology, Department of Internal Medicine, University of Miami
Miller School of Medicine, Miami, Florida 33136.
AN - 24082384
AU - Grover, P. M.
AU - O'Neill, B. P.
AU - Velazquez, O.
AU - Heldman, A. W.
AU - O'Neill, W. W.
AU - Cohen, M. G.
C2 - PMC3783150
DP - NLM
ET - 2013/10/02
IS - 4
J2 - Texas Heart Institute journal
KW - Aged, 80 and over
Aortic Valve Stenosis/complications/diagnosis/*therapy
Atrial Fibrillation/*complications/diagnosis
Cardiac Catheterization/*instrumentation
Critical Illness
*Embolic Protection Devices
Heart Diseases/diagnosis/*etiology
Heart Valve Prosthesis Implantation/*methods
Heart Ventricles
Humans
Intracranial Embolism/diagnosis/etiology/*prevention & control
Male
Thrombosis/diagnosis/*etiology
Treatment Outcome
Aortic valve stenosis/therapy
cerebral infarction/etiology
embolic protection devices
heart valve prosthesis implantation
intracranial embolism/prevention & control
stroke/etiology
thrombus, left ventricular
LA - eng
N1 - 1526-6702
Grover, Peeyush M
O'Neill, Brian P
Velazquez, Omaida
Heldman, Alan W
O'Neill, William W
Cohen, Mauricio G
Case Reports
Journal Article
Tex Heart Inst J. 2013;40(4):477-80.
PY - 2013
SN - 0730-2347 (Print)
0730-2347
SP - 477-80
ST - Cerebral protection against left ventricular thrombus during transcatheter
aortic valve replacement in a patient with critical aortic stenosis
T2 - Tex Heart Inst J
TI - Cerebral protection against left ventricular thrombus during transcatheter
aortic valve replacement in a patient with critical aortic stenosis
VL - 40
ID - 2870
ER -
TY - JOUR
AB - In a patient with complete heart block complicated by "Torsade de point"
(T.D.P.) we were able to record an M-mode echocardiogram during an attack of this
peculiar ventricular tachyarrhythmia. The aortic valve opening was inconstant,
incomplete and unequal during the T.D.P. (13 sec.), although the rate of the
tachyarrhythmia was almost constant. On the other hand, during a subsequent
ventricular pacing at a comparable rate like, the aortic valve opening was constant
and complete. On the basis of these observations we conclude that the reduction of
stroke volume, observed in T.D.P., is mainly due to mechanical failure as a result
of partial desynchronization of the ventricular activation, as in ventricular
fibrillation in which, however, the desynchronization is complete.
AN - 6667823
AU - Guaragna, R. F.
AU - Sangiorgio, P.
AU - Brunelli, D.
AU - Bracchetti, D.
DA - Nov
DP - NLM
ET - 1983/11/01
IS - 11
KW - Aged
*Echocardiography
Heart Block/*complications
Hemodynamics
Humans
Male
Syncope/etiology
Tachycardia/*complications
LA - ita
N1 - Guaragna, R F
Sangiorgio, P
Brunelli, D
Bracchetti, D
Case Reports
English Abstract
Journal Article
Italy
G Ital Cardiol. 1983 Nov;13(11):351-4.
OP - Aspetti emodinamici della torsione di punta: studio ecocardiografico di un
caso.
PY - 1983
SN - 0046-5968 (Print)
0046-5968
SP - 351-4
ST - [Hemodynamic aspects of torsade de pointes: echocardiographic study of a
case]
T2 - G Ital Cardiol
TI - [Hemodynamic aspects of torsade de pointes: echocardiographic study of a
case]
VL - 13
ID - 2772
ER -
TY - JOUR
AB - Cocaine use has increased considerably during the last twenty years and
several related complications can be identified. Clinical features of cocaine
intoxication are variable, but predominantly involve cardiovascular events. Chest
pain is the most main complaint; myocardial ischemia must be ruled out. Other
cardiovascular manifestations are left ventricular dysfunction, arrhythmia,
endocarditis and aortic dissection. Non-cardiac complications include neurological
(seizures, stroke, cerebral hemorrhage), respiratory (asthma, interstitial
pneumonitis, pulmonary edema), renal (acute renal failure, rhabdomyolysis) and
obstetrical disorders. Detection of cocaine in the urine provides the diagnosis.
Symptomatic treatment is generally given, combining conventional treatment of the
complication and broad use of benzodiazepines.
AD - Service de Réanimation Médicale, Hôpital Européen Georges-Pompidou, 20, rue
Leblanc, 75908 Paris Cedex 15, France. emmanuel.guerot@hop.egp.ap-hop-paris.fr
AN - 12218880
AU - Guerot, E.
AU - Sanchez, O.
AU - Diehl, J. L.
AU - Fagon, J. Y.
DA - May
DP - NLM
ET - 2002/09/10
IS - 3 Suppl
J2 - Annales de medecine interne
KW - Adult
Cardiovascular Diseases/*chemically induced
Chest Pain/etiology
Cocaine/*adverse effects
Cocaine-Related Disorders
Dopamine Uptake Inhibitors/*adverse effects
Female
Humans
Kidney Diseases/*chemically induced
Nervous System Diseases/chemically induced
Pregnancy
Pregnancy Complications/chemically induced
LA - fre
N1 - Guerot, Emmanuel
Sanchez, Olivier
Diehl, Jean-Luc
Fagon, Jean-Yves
English Abstract
Journal Article
Review
France
Ann Med Interne (Paris). 2002 May;153(3 Suppl):1S27-31.
OP - Complications aiguës dans l'usage de cocaïne.
PY - 2002
SN - 0003-410X (Print)
0003-410x
SP - 1s27-31
ST - [Acute complications in cocaine users]
T2 - Ann Med Interne (Paris)
TI - [Acute complications in cocaine users]
VL - 153
ID - 3068
ER -
TY - JOUR
AB - OBJECTIVE: The objective of this study was to evaluate the efficacy of
protocolized use of catheter-directed thrombolysis and echocardiography in
submassive pulmonary embolism patients. METHODS: A retrospective study at a single
institution of 28 patients that presented with submassive pulmonary embolism from
July 2016 to September 2019 was performed. All patients were diagnosed using chest
computed tomography demonstrating a pulmonary embolism and abnormal right
ventricular to left ventricular ratio. Patients with severe right heart dysfunction
(right ventricular to left ventricular ratio ⩾1.4) were protocolized to receive
catheter-directed thrombolysis via EkoSonic catheters (EKOS Corporation, Bothell,
WA, United States). Transthoracic echocardiogram was performed after 24 hours to
assess right ventricular function and determine the need to continue thrombolysis.
Patients after discharge then received follow-up echocardiograms at 6 weeks to
determine new post-treatment baseline. RESULTS: The mean patient age was 54.6
years, mean body mass index was 35.0, and mean right ventricular to left
ventricular ratio on admission computed tomography imaging was 1.70. Interval mean
right ventricular to left ventricular ratio on echocardiography during thrombolysis
therapy was 1.01 (p < 0.00001). Patients were tachycardic on admission (mean heart
rate 102.2 beats per minute) with improvement by completion of thrombolysis (mean
heart rate 72.9 beats per minute) (p < 0.00001). There was a 0% incidence of
periprocedural complications. Overall 30-day complication rate was 7.1% (n = 1
arrhythmia, n = 1 delayed intracranial hemorrhage). At 6-week follow-up, 91% of the
patients who received echocardiography had normal right ventricular function.
CONCLUSION: This retrospective study demonstrates the effectiveness of protocolized
use of catheter-directed thrombolysis and echocardiography in reversing severe
right heart dysfunction in submassive pulmonary embolism patients.
AD - Department of Surgery, School of Medicine, University of New Mexico,
Albuquerque, NM, USA.
Division of Vascular Surgery, School of Medicine, University of New Mexico,
Department of Critical Care, School of Medicine, University of New Mexico,
AN - 31948384
AU - Guliani, S.
AU - Das Gupta, J.
AU - Osofsky, R.
AU - Marek, J.
AU - Rana, M. A.
AU - Marinaro, J.
DA - Jan 17
DO - 10.1177/0267659119896891
DP - NLM
ET - 2020/01/18
J2 - Perfusion
KW - EkoSonic Endovascular System (EKOS Corporation, Bothell, WA, United States)
catheter-directed thrombolysis
echocardiography
severe right heart dysfunction
submassive pulmonary embolism
LA - eng
N1 - 1477-111x
Guliani, Sundeep
Das Gupta, Jaideep
Orcid: 0000-0003-3748-1568
Osofsky, Robin
Marek, John
Rana, Muhammad Ali
Marinaro, Jon
Journal Article
England
Perfusion. 2020 Jan 17:267659119896891. doi: 10.1177/0267659119896891.
PY - 2020
SN - 0267-6591
SP - 267659119896891
ST - Protocolized use of catheter-directed thrombolysis and echocardiography is
highly effective in reversing acute right heart dysfunction in severe submassive
pulmonary embolism patients
T2 - Perfusion
TI - Protocolized use of catheter-directed thrombolysis and echocardiography is
highly effective in reversing acute right heart dysfunction in severe submassive
pulmonary embolism patients
ID - 3104
ER -
TY - JOUR
AB - It is well known that patients with ischemic stroke show ST-T abnormalities
and various rhythm abnormalities on an electrocardiogram (ECG). The most commonly
encountered rhythm abnormality is atrial fibrillation. It was recently shown that
paroxysmal atrial fibrillation (PAF) is an important causative factor in patients
with stroke. Detection of PAF is important in identifying the cause, prognosis, and
treatment in patients with thromboembolic stroke. Investigators in the present
study followed patients with thromboembolic stroke who had been admitted to the
emergency department in sinus rhythm; 24-h Holter monitoring was used, and patients
were assessed at referral and every 6 h for 24 h with ECG, which was used to detect
rhythm disturbances, especially PAF. In 26 patients with stroke who came to the
emergency department, acute thromboembolic stroke was diagnosed on the basis of
magnetic resonance imaging; no rhythm abnormalities were noted on Holter
monitoring. Eighteen patients were male and 8 were female (mean age: 66+/-13 y).
Arrhythmia was identified on ECG in 3 patients (11%) and on 24-h Holter monitoring
in 24 patients (92%). PAF was diagnosed in 3 patients (11%) on ECG and in 11
patients (42%) on Holter monitoring. In 2 patients, nonsustained ventricular
tachycardia was detected only on Holter monitoring, which was found to be
significantly superior to ECG for the detection of arrhythmias (P<.001).
Investigators found no significant relationship between PAF and variables such as
hypertension, diabetes, coronary artery disease, history of myocardial infarction,
ST-T changes, and elevations in cardiac markers. However, a significant
relationship (P<.01) was seen between nonsustained ventricular tachycardia and a
history of myocardial infarction. No relationship was discerned between arrhythmia
and stroke localization. Study results suggested that (1) PAF is a commonly
diagnosed rhythm abnormality, and (2) Holter monitoring is superior to routine ECG
for the detection of arrhythmias such as PAF in patients anticipated to have
thromboembolic stroke with sinus rhythm.
AD - Department of Emergency Medicine, Ankara University Faculty of Medicine,
Ankara, Turkey.
AN - 17276953
AU - Gunalp, M.
AU - Atalar, E.
AU - Coskun, F.
AU - Yilmaz, A.
AU - Aksoyek, S.
AU - Aksu, N. M.
AU - Sivri, B.
DA - Nov-Dec
DO - 10.1007/bf02850206
DP - NLM
ET - 2007/02/06
IS - 6
J2 - Advances in therapy
KW - Aged
Arrhythmia, Sinus/*complications
Atrial Fibrillation/*diagnosis/etiology
Brain/diagnostic imaging/pathology
Brain Ischemia/*complications
Echoencephalography
*Electrocardiography, Ambulatory
Female
Humans
Male
Stroke/blood/*complications
Tachycardia, Ventricular/diagnosis/etiology
Thromboembolism/*complications
LA - eng
N1 - Gunalp, Muge
Atalar, Enver
Coskun, Figen
Yilmaz, Arda
Aksoyek, Serdar
Aksu, Nalan Metin
Sivri, Bulent
Journal Article
United States
Adv Ther. 2006 Nov-Dec;23(6):854-60. doi: 10.1007/BF02850206.
PY - 2006
SN - 0741-238X (Print)
0741-238x
SP - 854-60
ST - Holter monitoring for 24 hours in patients with thromboembolic stroke and
sinus rhythm diagnosed in the emergency department
T2 - Adv Ther
TI - Holter monitoring for 24 hours in patients with thromboembolic stroke and
sinus rhythm diagnosed in the emergency department
VL - 23
ID - 2680
ER -
TY - JOUR
AB - The majority of patients with atrial fibrillation (AF) seeking medical
treatment are in the elderly age group and the management of these patients is
often complicated by comorbidities, challenging the pharmacological management of
these patients. Owing to hypertension, congestive heart failure, left ventricular
hypertrophy and coronary artery disease, antiarrhythmic treatment often fails due
to side effects, proarrhythmia or poor rhythm control. In recent years,
radiofrequency catheter ablation has been widely performed as an effective
treatment for recurrent, drug-refractory AF. However, few elderly patients were
included in prior AF catheter ablation studies and the current guidelines for
catheter ablation of AF recommend a conservative approach in the elderly population
owing to the absence of clinical data. However, study results from our group and
others suggest that catheter ablation is a safe and effective treatment for
patients over the age of 65 years with symptomatic, drug-refractory AF and,
therefore, patients should not be excluded from catheter ablation on the basis of
age alone. In this article, we discuss the pharmacological (rhythm control, rate
control and anticoagulation) and catheter management of AF in the elderly
population.
AD - Cardiology Department, Cardiovascular Center, University Hospital of Zurich,
Zurich, Switzerland. laurent.haegeli@usz.ch
AN - 21627480
AU - Haegeli, L. M.
AU - Duru, F.
DA - May
DO - 10.2217/fca.11.22
DP - NLM
ET - 2011/06/02
IS - 3
J2 - Future cardiology
KW - Age Factors
*Aging
Atrial Fibrillation/*drug therapy/pathology/surgery
Humans
Prevalence
LA - eng
N1 - 1744-8298
Haegeli, Laurent M
Duru, Firat
Journal Article
Review
England
Future Cardiol. 2011 May;7(3):415-23. doi: 10.2217/fca.11.22.
PY - 2011
SN - 1479-6678
SP - 415-23
ST - Atrial fibrillation in the aging heart: pharmacological therapy and catheter
ablation in the elderly
T2 - Future Cardiol
TI - Atrial fibrillation in the aging heart: pharmacological therapy and catheter
ablation in the elderly
VL - 7
ID - 2657
ER -
TY - JOUR
AB - Atrial fibrillation (AF) is a common cause of ischemic stroke. Because
anticoagulation can prevent many of these strokes, identifying patients with occult
intermittent AF is important. Hypertension is a common precursor of stroke and AF.
Prolonged nonselective electrocardiographic monitoring of patients after ischemic
stroke has yielded only a small number of patients with occult intermittent AF. To
determine the importance of AF in nonhemorrhagic stroke, we retrospectively studied
799 patients admitted with ischemic stroke over 31 months. AF was present on the
admitting electrocardiogram in 154 patients (19.3%), diagnosed later during the
stroke admission in 58 (7.3%), and found only during another admission before/after
the stroke admission in 46 (5.8%). AF was intermittent in 123 patients, 47.7% (95%
CI 41.6 to 53.8) of patients with AF, and not present on initial electrocardiogram
in 40.3% of patients with AF. In 633 patients with hypertension, AF occurred in
34.9% versus 22.2% without hypertension (p <0.01). Echocardiogram revealed a left
atrium > or =4.0 cm in 81.3% of patients with AF versus 42.4% of those without AF
(odds ratio [OR] 5.85, 95% confidence interval [CI] 3.87 to 8.96, p <0.001);
ejection fraction was <50% in 27.7% of patients with AF versus 12.6% of those
without AF (OR 2.63, 95% CI 1.65 to 4.22, p <0.001); and the left ventricle was >
or =5.6 cm in 13.8% in patients with AF versus 6.7% in those without AF (OR 2.21,
95% CI 1.61 to 3.04, p <0.01). Clinically, congestive heart failure (31% vs 10.4%,
OR 3.89, 95% CI 2.76 to 5.73) and coronary disease (31% vs 21.4%, OR 1.65, 95% CI
1.15 to 2.37) were present more often in patients with AF (p <0.001). Left
ventricular hypertrophy, diastolic dysfunction, and diabetes were common in all
hypertensive patients with stroke. In conclusion, hypertensive patients with these
risk factors should undergo prolonged electrocardiographic event monitoring to
identify occult intermittent AF so measures can be taken to prevent a second stroke
and possibly a first stroke.
AD - Division of Cardiology, Department of Internal Medicine, Hackensack
University Medical Center, Hackensack, NJ, USA. jihaft@aol.com
AN - 18993153
AU - Haft, J. I.
AU - Teichholz, L. E.
DA - Nov 15
DO - 10.1016/j.amjcard.2008.07.009
DP - NLM
ET - 2008/11/11
IS - 10
KW - Aged
Atrial Fibrillation/*diagnostic imaging/*etiology
Female
Humans
Hypertension/*complications
Male
Risk Factors
Ultrasonography
LA - eng
N1 - 1879-1913
Haft, Jacob I
Teichholz, Louis E
Journal Article
United States
Am J Cardiol. 2008 Nov 15;102(10):1348-51. doi: 10.1016/j.amjcard.2008.07.009. Epub
2008 Sep 4.
PY - 2008
SN - 0002-9149
SP - 1348-51
ST - Echocardiographic and clinical risk factors for atrial fibrillation in
hypertensive patients with ischemic stroke
T2 - Am J Cardiol
TI - Echocardiographic and clinical risk factors for atrial fibrillation in
hypertensive patients with ischemic stroke
VL - 102
ID - 2631
ER -
TY - JOUR
AB - OBJECTIVE: A spinal cord injury (SCI) above the sixth thoracic vertebra
interrupts the supraspinal control of the sympathetic nervous system causing an
imbalance between the sympathetic and the parasympathetic nervous system. This
article focuses on the symptoms, treatment and examination of autonomic
disturbances of the cardiovascular and the urinary system after a SCI. METHODS: A
non-systematic literature search in the PubMed database. RESULTS: Frequent
complications in the acute phase of cervical and high thoracic SCI are
bradyarrhythmias, hypotension, hypothermia/hyperthermia, increased neurogenic
shock, vagovagal reflex, supraventricular/ventricular ectopic beats, vasodilatation
and congestion. Serious complications in the chronic phase of SCI are orthostatic
hypotension, impaired cardiovascular reflexes, autonomic dysreflexia (AD), reduced
sensation of cardiac pain, loss of reflex cardiac acceleration, quadriplegic
cardiac atrophy due to loss of left ventricular mass and pseudo-myocardial
infarction. AD is associated with a sudden, uncontrolled sympathetic response,
triggered by stimuli below the injury. It may cause mild symptoms like skin rash or
slight headache, but also severe hypertension, cerebral haemorrhage and death.
Early recognition and prompt treatment are important. Urinary autonomic
dysfunctions include hyperreflexia or areflexia of detrusor and/or sphincter of the
bladder. CONCLUSIONS: Patients with SCI have a high risk of cardiovascular
complications, AD and urinary autonomic dysfunction both in the acute phase and
later, affecting their prognosis and quality of life. Knowledge of cardiovascular
and urological complications after SCI is important for proper diagnosis and
treatment.
AD - Department of Neurology, Haukeland University Hospital, Bergen, Norway
Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.
ellen.merete.hagen@helse-bergen.no
AN - 21711260
AU - Hagen, E. M.
AU - Faerestrand, S.
AU - Hoff, J. M.
AU - Rekand, T.
AU - Gronning, M.
DO - 10.1111/j.1600-0404.2011.01547.x
DP - NLM
ET - 2011/07/08
IS - 191
J2 - Acta neurologica Scandinavica. Supplementum
KW - Autonomic Nervous System Diseases/*etiology/physiopathology
Cardiovascular Diseases/*etiology/physiopathology
Humans
Spinal Cord Injuries/*complications/physiopathology
Thoracic Vertebrae
Urologic Diseases/*etiology/physiopathology
LA - eng
N1 - 1600-5449
Hagen, E M
Faerestrand, S
Hoff, J M
Rekand, T
Gronning, M
Journal Article
Review
Denmark
Acta Neurol Scand Suppl. 2011;(191):71-8. doi: 10.1111/j.1600-0404.2011.01547.x.
PY - 2011
SN - 0065-1427
SP - 71-8
ST - Cardiovascular and urological dysfunction in spinal cord injury
T2 - Acta Neurol Scand Suppl
TI - Cardiovascular and urological dysfunction in spinal cord injury
ID - 3142
ER -
TY - JOUR
AB - BACKGROUND: The aim of this paper is to provide an overview of the autonomic
innervation of the cardiovascular system and the cardiovascular sequelae of spinal
cord injuries. METHOD: A literature search was carried out in the PubMed database,
with the search phrases "traumatic spinal cord injury"/"traumatic spinal cord
injuries" together with "autonomic dysfunction", "autonomic dysreflexia" and
"cardiovascular disease". RESULTS: The most important cardiovascular complications
in the acute phase are bradyarrhythmia, hypotension, enhanced vasovagal reflexes,
supraventricular/ventricular ectopic beats, vasodilation and venous stasis.
Important in the chronic phase are orthostatic hypotension and impaired regulation
of blood pressure, blood volume and body temperature. Tetraplegia is frequently
accompanied by autonomic dysreflexia, impaired transmission of cardial pain, loss
of muscle mass in the left ventricle and pseudoinfarction. Patients with injuries
above the sixth thoracic vertebra have a predisposition for autonomic dysreflexia.
This is a condition characterised by sudden, uncontrolled sympathetic response
accompanied by a rise in blood pressure. Autonomic dysreflexia usually leads to
headaches and erythema on the upper chest. The condition may cause cerebral
haemorrhage and is potentially life threatening. Patients with spinal cord injuries
have an increased risk of atherosclerotic disease due to overweight, lipid
disorders, metabolic syndrome and diabetes. They are predisposed to thrombotic
emboli due to venous stasis and hypercoagulopathy, particularly immediately after
the injury. INTERPRETATION: Knowledge of cardiovascular sequelae after spinal cord
injuries and assessment of these is important for correct diagnostics, planning of
preventive measures and optimal treatment.
AD - Nevrologisk avdeling, Haukeland universitetssykehus, ogInstitutt for klinisk
medisin, Universitet i Bergen. ellen.merete.hagen@helse-bergen.no
AN - 22614315
AU - Hagen, E. M.
AU - Rekand, T.
AU - Grønning, M.
AU - Færestrand, S.
DA - May 15
DO - 10.4045/tidsskr.11.0551
DP - NLM
ET - 2012/05/23
IS - 9
J2 - Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny
raekke
Autonomic Dysreflexia/etiology
Autonomic Nervous System Diseases/diagnosis/etiology/mortality/*physiopathology
*Cardiovascular Diseases/diagnosis/etiology/mortality/physiopathology
Humans
Reflex/physiology
Risk Factors
Spinal Cord Injuries/classification/*complications/mortality/physiopathology
Thromboembolism/etiology
LA - eng
nor
N1 - 0807-7096
Hagen, Ellen Merete
Rekand, Tiina
Grønning, Marit
Færestrand, Svein
Journal Article
Review
Norway
Tidsskr Nor Laegeforen. 2012 May 15;132(9):1115-20. doi: 10.4045/tidsskr.11.0551.
PY - 2012
SN - 0029-2001
SP - 1115-20
ST - Cardiovascular complications of spinal cord injury
T2 - Tidsskr Nor Laegeforen
TI - Cardiovascular complications of spinal cord injury
VL - 132
ID - 2985
ER -
TY - JOUR
AB - HISTORY AND CLINICAL FINDINGS: A 78-year-old patient experienced dizziness,
impairment of mnemic and cognitive function, chronic fatigue and recurrent syncope.
INVESTIGATIONS: Hypertensive heart disease, reduced left ventricular function, and
ventricular ectopia classification Lown IVb was documented. Computed tomography
showed minimal brain atrophia. Stenoses of the brain supplying arteries and of
other intracranial diseases were excluded. A distinct correlation between cardiac
output and cerebral blood flow in correspondence to changes of heart rate were
found (cardiac output 4.2 l/min during sinus rhythm, 7.4 l/min during temporary
atrial pacing--AAI-Mode with a pacing rate of 90/min; 4.8 l/min--AAI-Mode with a
pacing rate of 120/min; cerebral blood flow: 70, 74 and 62 ml/100 g per minute,
respectively). Thus, impairment of cerebral blood flow autoregulation can be
assumed. TREATMENT AND COURSE: After implantation of a permanent pacemaker the
patient was without any complaints. The mnemic and cognitive function improved,
dizziness and fatigue disappeared. Synopsis did not occur. 14 months later a sudden
onset of complaints occurred caused by atrial fibrillation (heart rate 120/min).
Cardiac output and cerebral blood flow were now 4.0 l/min and 35 ml/100 g per
minute. After antiarrhythmic drug therapy and restoration of sinus rhythm cardiac
output and cerebral blood flow increased and the complaints disappeared again.
CONCLUSION: In patients with impaired capacity of cerebral autoregulation a reduced
cardiac function and output can induce a reduction of cerebral blood flow. Thus,
impairment of mnemic and cognitive function as well as other unspecific
neurological deficits can be caused. In these cases pacemaker therapy has to be
discussed as an effective therapeutical concept.
AD - Medizinische Universitätsklinik und Poliklinik, Leipzig. hagendorff@gmx.net
AN - 10742825
AU - Hagendorff, A.
AU - Dettmers, C.
AU - Jung, W.
AU - Hümmelgen, M.
AU - Kölsch, C.
AU - Hartmann, A.
AU - Lüderitz, B.
AU - Pfeiffer, D.
DA - Mar 10
DO - 10.1055/s-2007-1024118
DP - NLM
ET - 2000/04/01
IS - 10
KW - Aged
Atrial Fibrillation/drug therapy/physiopathology
Brain/*blood supply
Cardiac Output
Cardiovascular Diseases/*prevention & control
Cerebrovascular Circulation/*physiology
Cognition Disorders/prevention & control
Dizziness/prevention & control
Fatigue/prevention & control
Heart Rate
Humans
Male
Memory Disorders/prevention & control
Regional Blood Flow
Syncope/prevention & control
Thermodilution
LA - ger
N1 - Hagendorff, A
Dettmers, C
Jung, W
Hümmelgen, M
Kölsch, C
Hartmann, A
Lüderitz, B
Pfeiffer, D
Case Reports
English Abstract
Journal Article
Germany
Dtsch Med Wochenschr. 2000 Mar 10;125(10):286-9. doi: 10.1055/s-2007-1024118.
OP - Herzschrittmacher-Therapie zur Optimierung der Hirndurchblutung. Eine
Möglichkeit zur Prävention zerebrovaskulärer Erkrankungen?
PY - 2000
SN - 0012-0472 (Print)
0012-0472
SP - 286-9
ST - [Cardiac pacemaker therapy for optimizing brain circulation. A possible
prevention for cerebrovascular diseases?]
TI - [Cardiac pacemaker therapy for optimizing brain circulation. A possible
prevention for cerebrovascular diseases?]
VL - 125
ID - 3003
ER -
TY - JOUR
AB - A pacemaker syndrome manifested as transient sensoric aphasia in a 68-year-
old woman with a VVI-pace-maker implanted after SA-block. The attack occurred
during long-term blood pressure recording and Holter monitoring. Borderline
hypotension was documented during ventricular pacing which induced a retrograde
excitation of the atrium. Clinical investigations excluded any intracranial
abnormality, any source of embolism or stenosis of extra- and intracranial cerebral
arteries. Cerebral blood flow measurements revealed a significant increase during
pacing at elevated heart rate. Therefore, a device for AV-sequential pacing was
implanted and basic pacing rate was elevated. The present case report indicates
that focal and not only global cerebral ischemia can be produced by an impairment
of systemic hemodynamics due to hypotension and a pacemaker syndrome. Improvement
of cerebral blood flow during pacing is an unexpected finding contrasting with the
concept of autoregulation. In addition, pacemaker implantation should be discussed
in patients with transient cerebral perfusion deficits if an improvement of
cerebral blood flow is documented along with rising heart rate.
AD - Medizinische Universitätsklinik Bonn.
AN - 7846929
AU - Hagendorff, A.
AU - Pizzulli, L.
AU - Dettmers, C.
AU - Block, A.
AU - Omran, H.
AU - Hartmann, A.
AU - Manz, M.
AU - Lüderitz, B.
DA - Dec
DP - NLM
ET - 1994/12/01
IS - 12
KW - Aged
Aphasia, Wernicke/*etiology
Blood Pressure Monitors
Brain/blood supply
Female
Homeostasis/physiology
Humans
Hypotension/*etiology
Sinoatrial Block/*therapy
Syndrome
LA - ger
N1 - Hagendorff, A
Pizzulli, L
Dettmers, C
Block, A
Omran, H
Hartmann, A
Manz, M
Lüderitz, B
Case Reports
English Abstract
Journal Article
Germany
Z Kardiol. 1994 Dec;83(12):908-11.
OP - Intermittierende fokale zerebrale Ischämie bei Hypotonie infolge eines
Schrittmachersyndroms.
PY - 1994
SN - 0300-5860 (Print)
0300-5860
SP - 908-11
ST - [Intermittent focal cerebral ischemia in hypotension due to pacemaker
syndrome]
T2 - Z Kardiol
TI - [Intermittent focal cerebral ischemia in hypotension due to pacemaker
syndrome]
VL - 83
ID - 2745
ER -
TY - JOUR
AB - BACKGROUND: Short periods of cerebral ischaemia during ventricular
defibrillation testing may be associated with neuropsychological impairment.
However, the impact of out-of-hospital ventricular fibrillation (VF) converted by
implantable cardioverter-defibrillator (ICD) shock on cognitive functioning is
unknown. AIM: To assess the impact of out-of-hospital VF converted by ICD shock on
cognitive functioning. METHODS: The study included 52 primary prevention ICD
recipients. Patients with a history of stroke or other neurological impairment,
previous head injury and individuals unable to see or speak to complete
neuropsychological tests were not included.Initially, a Mini-Mental State
Examination was performed in all patients and one patient with a result below 24
points was excluded from the study. The cognitive battery consisted of four tests
(six measurements): 1) the Digit Span subtest of Wechsler Adult Intelligence Scale-
Revised; 2) the Digit Symbol subtest of Wechsler Adult Intelligence Scale-Revised;
3) the Halstead-Reitan Trail-Making Test A and B; and 4) the Ruff Figural Fluency
Test. RESULTS: The mean time from ICD implantation to cognitive assessment was 26
months. During this period, 15 appropriate shocks for VF were observed in seven
(14%) patients. The patients with appropriate ICD therapy were significantly worse
in two out of the six neuropsychological measurements and had a significantly lower
aggregate result. In multivariate linear regression analysis, defibrillation
therapy was an independent factor of poor cognitive functioning, along with age and
education. CONCLUSIONS: Short periods of out-of-hospital VF converted by ICD are
associated with cognitive impairment in the recipients of primary prevention ICD.
AD - Wojskowy Instytut Medyczny. krystian.krzyzanowski@gmail.com.
AN - 23990235
AU - Hałas, K.
AU - Krzyżanowski, K.
AU - Krzyżanowska, E.
AU - Smurzyński, P.
AU - Ryczek, R.
AU - Michałkiewicz, D.
AU - Orski, Z.
AU - Makowski, K.
AU - Wierzbowski, R.
AU - Gielerak, G.
DO - 10.5603/KP.a2013.0215
DP - NLM
ET - 2013/08/31
IS - 2
KW - Aged
Cognition Disorders/*etiology
Female
Humans
Male
Middle Aged
Outpatients
Risk Factors
LA - eng
N1 - 1897-4279
Hałas, Katarzyna
Krzyżanowski, Krystian
Krzyżanowska, Ewa
Smurzyński, Paweł
Ryczek, Robert
Michałkiewicz, Dariusz
Orski, Zbigniew
Makowski, Karol
Wierzbowski, Robert
Gielerak, Grzegorz
Journal Article
Poland
Kardiol Pol. 2014;72(2):134-9. doi: 10.5603/KP.a2013.0215. Epub 2013 Aug 30.
PY - 2014
SN - 0022-9032
SP - 134-9
ST - Cognitive impairment after appropriate implantable cardioverter-defibrillator
therapy for ventricular fibrillation
T2 - Kardiol Pol
TI - Cognitive impairment after appropriate implantable cardioverter-defibrillator
therapy for ventricular fibrillation
VL - 72
ID - 2999
ER -
TY - JOUR
AB - OBJECTIVES: The goal of this study was to identify subgroups of arrhythmia
patients who do not benefit from use of the implantable cardiac defibrillator
(ICD). BACKGROUND: Treatment of serious ventricular arrhythmias has evolved toward
more common use of the ICD. Since estimates of the cost per year of life saved by
ICD therapy vary from $25,000 to perhaps $125,000, it is important to identify
patient subgroups that do not benefit from the ICD. METHODS: Data for 491 ICD
patients enrolled in the Antiarrhythmics Versus Implantable Defibrillators Study
were used to create a hazards model relating baseline factors to time to first
recurrent arrhythmia. The model was used to predict the hazard for recurrent
arrhythmia among all trial patients. A priori cut points provided lower and higher
recurrent arrhythmia risk strata. For each stratum the incremental years of life
due to ICD versus antiarrhythmic drug therapy were calculated. RESULTS: Factors
that predicted recurrent arrhythmia were: ventricular tachycardia as the index
arrhythmia, history of cerebrovascular disease, lower left ventricular ejection
fraction, a history of any tachyarrhythmia before the index event and the absence
of revascularization after the index event. Survival times (over a follow-up of
three years) were identical in each arm of the lowest risk sextile (survival
advantage 0.03 +/- 0.12 [se] years), while the survival advantage for patients
above the first sextile was 0.27 +/- 0.07 (se) years (two-sided p = 0.05).
CONCLUSIONS: Patients presenting with an isolated episode of ventricular
fibrillation in the absence of cerebrovascular disease or history of prior
arrhythmia who have undergone revascularization or who have moderately preserved
left ventricular function (left ventricular ejection fraction > 0.27) are not
likely to benefit from ICD therapy compared with amiodarone therapy.
AD - University of Washington, Seattle 98105, USA. avidctc@u.washington.edu
AN - 11263614
AU - Hallstrom, A. P.
AU - McAnulty, J. H.
AU - Wilkoff, B. L.
AU - Follmann, D.
AU - Raitt, M. H.
AU - Carlson, M. D.
AU - Gillis, A. M.
AU - Shih, H. T.
AU - Powell, J. L.
AU - Duff, H.
AU - Halperin, B. D.
DA - Mar 15
DO - 10.1016/s0735-1097(00)01208-0
DP - NLM
ET - 2001/03/27
IS - 4
KW - Aged
Arrhythmias, Cardiac/complications/mortality/physiopathology/*therapy
Female
Humans
Male
Middle Aged
Myocardial Revascularization
Recurrence
Stroke Volume
Survival Rate
LA - eng
N1 - Hallstrom, A P
McAnulty, J H
Wilkoff, B L
Follmann, D
Raitt, M H
Carlson, M D
Gillis, A M
Shih, H T
Powell, J L
Duff, H
Halperin, B D
Antiarrhythmics Versus Implantable Defibrillator (AVID) Trial Investigators
Journal Article
United States
J Am Coll Cardiol. 2001 Mar 15;37(4):1093-9. doi: 10.1016/s0735-1097(00)01208-0.
PY - 2001
SN - 0735-1097 (Print)
0735-1097
SP - 1093-9
ST - Patients at lower risk of arrhythmia recurrence: a subgroup in whom
implantable defibrillators may not offer benefit. Antiarrhythmics Versus
Implantable Defibrillator (AVID) Trial Investigators
TI - Patients at lower risk of arrhythmia recurrence: a subgroup in whom
implantable defibrillators may not offer benefit. Antiarrhythmics Versus
Implantable Defibrillator (AVID) Trial Investigators
VL - 37
ID - 2707
ER -
TY - JOUR
AB - Heart failure (HF) increases the risk of ischemic stroke. Data regarding the
incidence and predictors of ischemic stroke during hospitalization for HF are
limited. The study population of this retrospective cohort study consisted of
patients with congestive HF, consecutively admitted to our center from October 2010
to April 2014. We excluded patients complicated with acute myocardial infarction,
infective endocarditis, and takotsubo cardiomyopathy. We also excluded those with
dialysis or mechanical circulatory support. We investigated the incidence of
ischemic stroke during hospitalization for HF. Thereafter, we divided the patients
without oral anticoagulants at admission into two groups: patients with ischemic
stroke and those without it, and explored the predictors of ischemic stroke. A
total of 558 patients (287 without atrial fibrillation (AF), 271 with AF) were
enrolled. The mean age was 76.8 ± 12.3 years, and 244 patients (44 %) were female.
The mean left-ventricular ejection fraction was 47.4 %. Oral anticoagulants were
prescribed in 147 patients (8 without AF, 139 with AF). During hospitalization
(median length 18 days), symptomatic ischemic stroke (excluding catheter-related)
occurred in 15 patients (2.7 % of the total, 8 without AF, 7 with AF). Predictors
significantly associated with increased risk of ischemic stroke in patients without
oral anticoagulants were as follows; short-term increases in blood urea nitrogen
after admission (at day 3; odds ratio (per 1 md/dl): 1.06, 95 % confidence interval
(CI) 1.01-1.11, p = 0.02, and at day 7; odds ratio: 1.03, 95 % CI 1.00-1.07,
p = 0.03, respectively), and previous stroke (odds ratio; 3.33, 95 % CI 1.01-11.00,
p = 0.04). The incidence of ischemic stroke during hospitalization for HF was high,
even in patients without AF. Previous stroke and short-term increases in blood urea
nitrogen was significantly associated with the incidence of ischemic stroke.
AD - Department of Cardiology, National Hospital Organization Kyoto Medical
Center, 1-1, Mukaihata-cho, Fukakusa, Fushimi-ku, Kyoto, 612-8555, Japan.
Department of Neurology, National Hospital Organization Kyoto Medical Center, 1-1,
Mukaihata-cho, Fukakusa, Fushimi-ku, Kyoto, Japan.
Department of Neurology, Rakuwakai Otowa Hospital, 2 otowachinzi-cho, Yamashina-ku,
Kyoto, Japan.
Department of Cardiology, National Hospital Organization Kyoto Medical Center, 1-1,
Mukaihata-cho, Fukakusa, Fushimi-ku, Kyoto, 612-8555, Japan. akao@kuhp.kyoto-
u.ac.jp.
AN - 26219729
AU - Hamatani, Y.
AU - Iguchi, M.
AU - Nakamura, M.
AU - Ohtani, R.
AU - Yamashita, Y.
AU - Takagi, D.
AU - Unoki, T.
AU - Ishii, M.
AU - Masunaga, N.
AU - Ogawa, H.
AU - Hamatani, M.
AU - Abe, M.
AU - Akao, M.
DA - Jul
DO - 10.1007/s00380-015-0719-4
DP - NLM
ET - 2015/07/30
IS - 7
J2 - Heart and vessels
Aged
Aged, 80 and over
Atrial Fibrillation/diagnosis/drug therapy/epidemiology
Biomarkers/blood
Blood Urea Nitrogen
Brain Ischemia/blood/diagnosis/*epidemiology
Female
Heart Failure/blood/diagnosis/*epidemiology/therapy
*Hospitalization
Humans
Incidence
Japan/epidemiology
Male
Middle Aged
Odds Ratio
Risk Factors
Stroke/blood/diagnosis/*epidemiology
Time Factors
*Heart failure
*Ischemic stroke
*Predictors
LA - eng
N1 - 1615-2573
Hamatani, Yasuhiro
Iguchi, Moritake
Nakamura, Michikazu
Ohtani, Ryo
Yamashita, Yugo
Takagi, Daisuke
Unoki, Takashi
Ishii, Mitsuru
Masunaga, Nobutoyo
Ogawa, Hisashi
Hamatani, Mio
Abe, Mitsuru
Akao, Masaharu
Journal Article
Observational Study
Japan
Heart Vessels. 2016 Jul;31(7):1154-61. doi: 10.1007/s00380-015-0719-4. Epub 2015
Jul 29.
PY - 2016
SN - 0910-8327
SP - 1154-61
ST - Incidence and predictors of ischemic stroke during hospitalization for
congestive heart failure
T2 - Heart Vessels
TI - Incidence and predictors of ischemic stroke during hospitalization for
VL - 31
ID - 2377
ER -
TY - JOUR
AB - BACKGROUND AND PURPOSE: The incidence of heart failure increases the
subsequent risk of ischemic stroke, and its risk could be higher in the short-term
period after an acute heart failure (AHF) event. However, its determinants remain
to be clarified. Plasma D-dimer level reflects fibrin turnover and exhibits unique
properties as a biomarker of thrombosis. The aim of this study is to investigate
whether D-dimer level is a determinant of short-term incidence of ischemic stroke
in patients with AHF. METHODS: We examined 721 consecutive hospitalized AHF
patients with plasma D-dimer level on admission from our prospective registry
between January 2013 and May 2016. The study end points were incidence of ischemic
stroke during hospitalization and at 30 days after admission. RESULTS: Of the total
participants (mean age, 76 years; male, 60%; atrial fibrillation, 54%; mean left
ventricular ejection fraction, 38%), in-hospital ischemic stroke occurred in 18
patients (2.5%) during a median hospitalization period of 21 days, and 30-day
ischemic stroke occurred in 16 patients (2.2%). Higher D-dimer level on admission
was an independent determinant of subsequent risk of in-hospital ischemic stroke
even after adjustment by CHA(2)DS(2)-VASc score (odds ratio, 2.29; 95% confidence
interval, 1.46-3.60; P<0.001) or major confounders, including age, atrial
fibrillation, and antithrombotic therapy (odds ratio, 2.31; 95% confidence
interval, 1.43-3.74; P<0.001). Subgroup analyses showed consistent findings in
patients without atrial fibrillation (odds ratio, 2.46; 95% confidence interval,
1.39-4.54; P=0.002) and those without antithrombotic therapy (odds ratio, 2.79; 95%
confidence interval, 1.53-5.57; P<0.001). Similar results were obtained for 30-day
ischemic stroke as an alternative outcome. CONCLUSIONS: Elevated plasma D-dimer
level on admission was significantly associated with increased incidence of
ischemic stroke shortly after admission for AHF, suggesting a predictive role of D-
dimer for short-term ischemic stroke events in patients with AHF. CLINICAL TRIAL
REGISTRATION: URL: https://www.umin.ac.jp/ctr/index.htm. Unique identifier:
UMIN000017024.
AD - Department of Cardiovascular Medicine (Y. Hamatani, Y. Honda, H.N., S.H.,
N.I., Y.S., Y.A., T. Aiba, T. Noguchi, K.K., S.Y., H.Y., H.O.).
From the Department of Cardiovascular Medicine, Hokkaido University Graduate School
of Medicine, Japan (T. Nagai, T. Anzai) tnagai@huhp.hokudai.ac.jp.
Department of Statistics and Data Analysis, Center for Cerebral and Cardiovascular
Disease Information (M.N., K.N.).
Department of Cerebrovascular Medicine (K.T.), National Cerebral and Cardiovascular
Center, Osaka, Japan.
From the Department of Cardiovascular Medicine, Hokkaido University Graduate School
of Medicine, Japan (T. Nagai, T. Anzai).
AN - 29880555
AU - Hamatani, Y.
AU - Nagai, T.
AU - Nakai, M.
AU - Nishimura, K.
AU - Honda, Y.
AU - Nakano, H.
AU - Honda, S.
AU - Iwakami, N.
AU - Sugano, Y.
AU - Asaumi, Y.
AU - Aiba, T.
AU - Noguchi, T.
AU - Kusano, K.
AU - Toyoda, K.
AU - Yasuda, S.
AU - Yokoyama, H.
AU - Ogawa, H.
AU - Anzai, T.
DA - Jul
DO - 10.1161/strokeaha.118.021899
DP - NLM
ET - 2018/06/09
IS - 7
J2 - Stroke
KW - Age Factors
Aged
Atrial Fibrillation/blood/*complications
Biomarkers/blood
Brain Ischemia/blood/*etiology
Female
Fibrin Fibrinogen Degradation Products/*analysis
Heart Failure/blood/*complications
Humans
Male
Prospective Studies
Risk Assessment
Risk Factors
Stroke/blood/*etiology
*brain ischemia
*fibrin
*heart failure
*humans
*incidence
*stroke
LA - eng
N1 - 1524-4628
Hamatani, Yasuhiro
Nagai, Toshiyuki
Nakai, Michikazu
Nishimura, Kunihiro
Honda, Yasuyuki
Nakano, Hiroki
Honda, Satoshi
Iwakami, Naotsugu
Sugano, Yasuo
Asaumi, Yasuhide
Aiba, Takeshi
Noguchi, Teruo
Kusano, Kengo
Toyoda, Kazunori
Yasuda, Satoshi
Yokoyama, Hiroyuki
Ogawa, Hisao
Anzai, Toshihisa
NaDEF Investigators
Journal Article
United States
Stroke. 2018 Jul;49(7):1737-1740. doi: 10.1161/STROKEAHA.118.021899. Epub 2018 Jun
7.
PY - 2018
SN - 0039-2499
SP - 1737-1740
ST - Elevated Plasma D-Dimer Level Is Associated With Short-Term Risk of Ischemic
Stroke in Patients With Acute Heart Failure
T2 - Stroke
TI - Elevated Plasma D-Dimer Level Is Associated With Short-Term Risk of Ischemic
Stroke in Patients With Acute Heart Failure
VL - 49
ID - 2393
ER -
TY - JOUR
AB - Transient anoxic seizure upon application of pressure on a giant
pseudomeningocele has never been reported in the literature; such abrupt changes in
intracranial pressure due to large volume of cerebrospinal fluid (CSF)
translocation, if left untreated may lead to permanent cerebral hypoxic injury and
death. Here we describe a case of a 26-year-old woman who had undergone lumbar disc
surgery in another unit few months ago and developed a large lump around her back.
Any pressure on the lump resulted in headaches and at times episodes of seizures.
Clinical examination revealed a very large fluid-filled lump consistent with a
giant pseudomeningocele, confirmed by an MRI. A video EEG while applying pressure
on the lump was recorded. The patient developed a typical seizure attack with a
characteristic pattern of cerebral anoxia, and a paired ECG showed irregular rhythm
with junctional and ventricular ectopic beats during the latter part of the attack,
raising a suspicion of asystole. Upon relieving the pressure off the lump, the
patient gradually regained consciousness with no permanent neurological deficit. We
then discuss the pathophysiology of anoxic seizures and highlight the need to be
vigilant in managing patients with such lesions in order to prevent permanent
cerebral hypoxic injury and death.
AD - Department of Spinal Surgery, Northern General Hospital, Sheffield Teaching
Hospitals NHS Foundation Trust, Sheffield, UK. a.hamdan@doctors.org.uk.
Department of Neurosurgery, Royal Hallamshire Hospital, Sheffield Teaching
Hospitals NHS Foundation Trust, Sheffield, UK.
Department of Spinal Surgery, Northern General Hospital, Sheffield Teaching
Hospitals NHS Foundation Trust, Sheffield, UK.
AN - 29299677
AU - Hamdan, A.
AU - Saxena, A.
AU - Rao, G.
AU - Ivanov, M.
DA - Mar
DO - 10.1007/s00701-017-3446-z
DP - NLM
ET - 2018/01/05
IS - 3
J2 - Acta neurochirurgica
KW - Adult
Cardiac Complexes, Premature/etiology
Electrocardiography
Female
Humans
Hypoxia, Brain/*etiology
Intervertebral Disc Degeneration/surgery
Lumbar Vertebrae/surgery
Meningocele/*complications
Seizures/*etiology
*Anoxic seizure
*Cerebral hypoxia
*Electroencephalography
*Pseudomeningocele
LA - eng
N1 - 0942-0940
Hamdan, Alhafidz
Orcid: 0000-0002-0794-5504
Saxena, A
Rao, G
Ivanov, M
Case Reports
Journal Article
Austria
Acta Neurochir (Wien). 2018 Mar;160(3):479-485. doi: 10.1007/s00701-017-3446-z.
Epub 2018 Jan 3.
PY - 2018
SN - 0001-6268
SP - 479-485
ST - Compression of a giant pseudomeningocele causing transient anoxic seizures-a
case report
T2 - Acta Neurochir (Wien)
TI - Compression of a giant pseudomeningocele causing transient anoxic seizures-a
case report
VL - 160
ID - 3017
ER -
TY - JOUR
AB - BACKGROUND: Preprocedural transesophageal echocardiography (TEE) is used to
reduce the stroke during atrial fibrillation (AF) ablation. This study evaluated
whether routine preprocedural TEE in addition to multidetector computed tomography
(MDCT) is necessary to prevent periprocedural stroke in AF ablation. METHODS: Each
patient underwent MDCT and TEE (group 1, n=247) or MDCT alone (group 2, n=103) for
the initial evaluation before AF ablation. In group 2, TEE was performed only in
patients who had left atrial (LA) thrombus or blood stasis in MDCT. RESULTS: There
was no difference in sex, CHADS2 score, or LA dimension between the two groups. In
group 1, a thrombus was detected in 12 (5%) and 6 (2%) patients by the MDCT and
TEE, respectively. All (100%) patients, who were revealed to have thrombus in TEE,
also had a thrombus in MDCT. In group 2, 3 (3%) patients exhibited LA thrombus in
MDCT, among whom thrombus was observed in only one patient (1%) in TEE. AF ablation
was not performed in patients with thrombus. While one patient had a periprocedural
stroke in group 1, no patient had in group 2 (P=0.52). CONCLUSION: The overall
periprocedural stroke rate was low (0.3%) in AF patients on anticoagulation
therapy. The preprocedural MDCT detected all patients with the LA thrombus. In AF
patients with low CHADS2 score, optimal anticoagulation and relatively preserved
left ventricular ejection fraction, routine preprocedural TEE in addition to the
MDCT might not be necessary to decrease the periprocedural stroke rate.
AD - Cardiology Division, Department of Internal Medicine, Yonsei University
Medical College, Seoul, Republic of Korea.
AN - 23352487
AU - Han, J. H.
AU - Shin, D. H.
AU - Lee, H. J.
AU - Kim, Y. J.
AU - Lee, S. H.
AU - Shim, J.
AU - Uhm, J. S.
AU - Kim, J. Y.
AU - Chang, H. J.
AU - Pak, H. N.
AU - Lee, M. H.
AU - Joung, B.
DA - Oct 3
DO - 10.1016/j.ijcard.2012.12.096
DP - NLM
ET - 2013/01/29
IS - 3
Atrial Fibrillation/complications/*surgery
*Catheter Ablation
Female
Follow-Up Studies
Humans
Incidence
Male
Middle Aged
Multidetector Computed Tomography
Postoperative Complications/epidemiology/prevention & control
Preoperative Care/*methods
Stroke/diagnosis/etiology/*prevention & control
*Unnecessary Procedures
Anticoagulation
Atrial fibrillation
Stroke
Transesophageal echocardiography
LA - eng
N1 - 1874-1754
Han, Jae-Hyun
Shin, Dong-Ho
Lee, Hye-Jeong
Kim, Young Jin
Lee, Seung-Hyun
Shim, Jaemin
Uhm, Jae-Sun
Kim, Jong-Youn
Chang, Hyuk-Jae
Pak, Hui-Nam
Lee, Moon-Hyoung
Joung, Boyoung
Journal Article
Netherlands
Int J Cardiol. 2013 Oct 3;168(3):1992-6. doi: 10.1016/j.ijcard.2012.12.096. Epub
2013 Jan 23.
PY - 2013
SN - 0167-5273
SP - 1992-6
ST - Routine preprocedural transesophageal echocardiography might not be necessary
for stroke prevention evaluation in AF patients on anticoagulation therapy
T2 - Int J Cardiol
TI - Routine preprocedural transesophageal echocardiography might not be necessary
for stroke prevention evaluation in AF patients on anticoagulation therapy
VL - 168
ID - 2704
ER -
TY - JOUR
AB - Idiopathic aneurysms of the left ventricle (LV) are uncommon in Western
society. Multiple idiopathic LV aneurysms are distinctly unusual and are rarely
reported. As with aneurysms of atherosclerotic origin, these entities may be
associated with chest discomfort, congestive heart failure, cardiac dysrhythmias,
and thromboembolic phenomena. We present the case of a Japanese woman living in the
United States with chest discomfort, ventricular arrhythmias, and a previous
transient ischemic attack who demonstrated four discrete LV aneurysms on
ventriculography. Extensive evaluation demonstrated no clear cause for these
aneurysms. The patient was treated conservatively with medical therapy and has
continued to do well without adverse clinical sequelae.
AD - Department of Internal Medicine, David Grant Medical Center, Travis Air Force
Base, CA 94535, USA.
AN - 10377718
AU - Harris, G. A., Jr.
AU - Wong, A. K.
AU - Lantz, D. A.
DA - Jun
DP - NLM
ET - 1999/06/23
IS - 6
J2 - Military medicine
KW - Angiotensin-Converting Enzyme Inhibitors/therapeutic use
Electrocardiography
Female
Heart Aneurysm/complications/*diagnosis/drug therapy
Heart Block/etiology
Heart Ventricles
Humans
Japan/ethnology
Middle Aged
United States
LA - eng
N1 - Harris, G A Jr
Wong, A K
Lantz, D A
Case Reports
Journal Article
England
Mil Med. 1999 Jun;164(6):448-50.
PY - 1999
SN - 0026-4075 (Print)
0026-4075
SP - 448-50
ST - Multiple idiopathic left ventricular aneurysms in a Japanese woman
T2 - Mil Med
TI - Multiple idiopathic left ventricular aneurysms in a Japanese woman
VL - 164
ID - 2770
ER -
TY - JOUR
AB - Atrial fibrillation (AF) is associated with a substantially increased risk of
ischemic stroke. Recently, five randomized clinical trials independently assessed
the value of antithrombotic prophylaxis in AF patients. The rate of ischemic stroke
in patients receiving a placebo averaged 5% per year. On aggregate, anticoagulation
(INR 1.5 to 4.0) was shown to substantially (mean = 70%) reduce the risk of
arterial thromboembolism. The effect of acetylsalicylic acid (ASA) studied in two
trials was not uniform, but the efficacy of ASA was less than anticoagulation. ASA
appeared to prevent nonembolic strokes better than embolic strokes in AF patients.
The characterization of subgroups of AF patients who have relatively high or low
absolute stroke rates determines which patients gain greater or lesser benefit from
anticoagulant therapy. A multivariate analysis of a large cohort of placebo-treated
patients yielded three independent clinical predictors of an increased risk of
arterial thromboembolism: a history of hypertension, recent (within three months)
congestive heart failure and prior transient ischemic attack (TIA) or stroke, and
two echocardiographic predictors--left atrial size of greater than 4.6 cm and
impaired left ventricular function. At present, anticoagulation with warfarin (INR
2 - 3) is recommended in AF patients with one or more of these risk factors. The
European Atrial Fibrillation Trial studied only AF patients with prior stroke and
TIA and confirmed the superiority of warfarin over ASA for secondary prevention.
AD - University of Texas Health Science Center, San Antonio 78284.
AN - 7919069
AU - Hart, R. G.
DP - NLM
ET - 1994/01/01
IS - 1
J2 - Health reports
KW - Aged
Cerebrovascular Disorders/*prevention & control
Humans
Intracranial Embolism and Thrombosis/prevention & control
Middle Aged
Risk Factors
LA - eng
fre
N1 - Hart, R G
Journal Article
Review
Canada
Health Rep. 1994;6(1):126-31.
PY - 1994
SN - 0840-6529 (Print)
0840-6529
SP - 126-31
ST - Prevention of stroke in atrial fibrillation: an update
T2 - Health Rep
TI - Prevention of stroke in atrial fibrillation: an update
VL - 6
ID - 2969
ER -
TY - JOUR
AB - During ICD-implantation it is necessary to induce ventricular fibrillation
several times to determine the defibrillation threshold. In third generation ICDs
there are several options to induce ventricular fibrillation. We want to present a
new method, called T-wave-shock, which is first available in the PCD Jewel 7219
(Medtronic). The T-wave-shock is the delivery of a low-energy-shock into the
vulnerable period after ventricular stimulation with a basic cycle-length. We
applied the T-wave-shock in 46 consecutive ICD-recipients intraoperatively and at
the pre-hospital-discharge test. The method is highly effective when applying the
shock into the ascending part of the T-wave (98% of the patients were inducible),
and the duration of cardial and cerebral ischemia during induction is short
(between 3.1 and 3.8 s). This raises defibrillation efficacy.
AD - Herzzentrum Ludwigshafen.
AN - 7785300
AU - Hauer, B.
AU - Seidl, K.
AU - Senges, J.
DA - Apr
DP - NLM
ET - 1995/04/01
IS - 4
KW - Adult
Aged
Aged, 80 and over
Electrocardiography/*instrumentation
Equipment Design
Female
Humans
Male
Middle Aged
Ventricular Fibrillation/*physiopathology/therapy
LA - ger
N1 - Hauer, B
Seidl, K
Senges, J
English Abstract
Journal Article
Germany
Z Kardiol. 1995 Apr;84(4):284-8.
OP - Der T-Wellen-Schock: Eine neue, zuverlässige Methode zur Induktion von
Kammerflimmern bei der ICD-Testung.
PY - 1995
SN - 0300-5860 (Print)
0300-5860
SP - 284-8
ST - [The T-wave shock: a new reliable method for induction of ventricular
fibrillation in ICD testing]
T2 - Z Kardiol
TI - [The T-wave shock: a new reliable method for induction of ventricular
fibrillation in ICD testing]
VL - 84
ID - 2855
ER -
TY - JOUR
AB - Repeated induction of ventricular fibrillation (VF) with circulatory
compromise during implantable cardioverter defibrillator (ICD) testing may cause
cerebral injury. To test this hypothesis, somatosensory evoked potentials (SEP), a
more sensitive marker of injury, were recorded in patients (N = 10) undergoing ICD
implantation. SEP were recorded before induction of anesthesia, after induction of
anesthesia, before and at several times following induction of VF. Possible
modifying factors of the SEP measurements such as anesthetic application, blood
pressure, body temperature, and hematocrit remained constant throughout the
operations. Central conduction time was unaffected by ICD defibrillation testing.
Amplitude of SEP primary complexes was transiently reduced at 34.9% (P < 0.01) by
defibrillation testing, but returned to control within 10 minutes after testing. It
is concluded that while ICD defibrillation testing may produce transient changes in
SEP, there is no evidence of residual cerebral injury.
AD - Department of Anesthesiology, University of Heidelberg, Germany.
AN - 8167288
AU - Haussmann, R.
AU - Polarz, H.
AU - Rauch, H.
AU - Graf, B.
AU - Lang, J.
AU - Fleischer, F.
AU - Martin, E.
AU - Saggau, W.
DA - Feb
DO - 10.1016/1053-0770(94)90014-0
DP - NLM
ET - 1994/02/01
IS - 1
J2 - Journal of cardiothoracic and vascular anesthesia
KW - Adult
Aged
Cerebral Cortex/physiology
Evoked Potentials, Somatosensory/*physiology
Female
Humans
Ischemic Attack, Transient/*diagnosis/physiopathology
Male
Middle Aged
*Monitoring, Intraoperative
Neural Conduction/physiology
Recurrence
Spinal Nerves/physiology
Tachycardia, Ventricular/surgery
Ventricular Fibrillation/*physiopathology/surgery
LA - eng
N1 - Haussmann, R
Polarz, H
Rauch, H
Graf, B
Lang, J
Fleischer, F
Martin, E
Saggau, W
Journal Article
United States
J Cardiothorac Vasc Anesth. 1994 Feb;8(1):61-3. doi: 10.1016/1053-0770(94)90014-0.
PY - 1994
SN - 1053-0770 (Print)
1053-0770
SP - 61-3
ST - Evoked potential monitoring during repeatedly induced ventricular
fibrillation for internal defibrillator implantation
T2 - J Cardiothorac Vasc Anesth
TI - Evoked potential monitoring during repeatedly induced ventricular
fibrillation for internal defibrillator implantation
VL - 8
ID - 2757
ER -
TY - JOUR
AB - Stokes-Adams attacks are fairly common in children with congenital complete
heart block, but the occurrence of cerebral infarction is quite unusual. We present
the case of a 13-year-old boy with congenital heart block and an embolic stroke
involving the cerebral artery. Echocardiography revealed no valvular regurgitation,
hypokinetic segments, mural thrombus, or myxoma. Electrocardiographic monitoring
demonstrated good response of ventricular rate to exercise and no episodes of
atrial or ventricular dysrhythmia. It is assumed that embolism occurred due to
bradycardia.
AD - Department of Pediatrics, Tokushima University School of Medicine, Japan.
AN - 9562944
AU - Hayabuchi, Y.
AU - Matsuoka, S.
AU - Nii, M.
AU - Suzuya, H.
AU - Kuroda, Y.
C2 - PMC6656120
DA - Apr
DO - 10.1002/clc.4960210416
DP - NLM
ET - 1998/05/01
IS - 4
KW - Adolescent
Brain/blood supply/pathology
Cerebral Infarction/diagnosis/*etiology
Follow-Up Studies
Heart Block/complications/*congenital/therapy
Heart Rate
Humans
Intracranial Embolism and Thrombosis/complications/diagnosis
Male
LA - eng
N1 - 1932-8737
Hayabuchi, Y
Matsuoka, S
Nii, M
Suzuya, H
Kuroda, Y
Case Reports
Journal Article
Clin Cardiol. 1998 Apr;21(4):302-3. doi: 10.1002/clc.4960210416.
PY - 1998
SN - 0160-9289 (Print)
0160-9289
SP - 302-3
ST - Cerebral infarction in a patient with congenital complete heart block
T2 - Clin Cardiol
TI - Cerebral infarction in a patient with congenital complete heart block
VL - 21
ID - 2740
ER -
TY - JOUR
AB - We describe a patient who was treated with amiodarone for ventricular
arrhythmia based on arrhythmogenic right ventricular dysplasia and who subsequently
developed severe amiodarone-induced thyrotoxicosis. Discontinuation of amiodarone
resulted in sustained ventricular tachycardia, which was successfully treated with
a DC electrical shock, and subsequently atrial fibrillation, leading to brain
embolism due to occlusion of the left middle cerebral artery. Combination treatment
with amiodarone and prednisolone was effective both in reducing the serum
concentration of thyroid hormones and in improving the patient's general condition.
As the use of amiodarone becomes more widespread, treatment with prednisolone for
this kind of thyrotoxicosis, which is resistant to conventional treatment, will be
required increasingly frequently because iodine overload of the thyroid gland
persists for some time after discontinuation of amiodarone treatment.
AD - Department of Cardiology, Ogaki Municipal Hospital, Gifu, Japan.
AN - 9152790
AU - Hayashi, K.
AU - Sone, T.
AU - Suzuki, T.
AU - Numaguchi, Y.
AU - Kondoh, J.
AU - Tsuboi, H.
AU - Sassa, H.
DA - Apr
DO - 10.1253/jcj.61.361
DP - NLM
ET - 1997/04/01
IS - 4
J2 - Japanese circulation journal
KW - Adult
Amiodarone/*adverse effects/therapeutic use
Anti-Arrhythmia Agents/*adverse effects/therapeutic use
Anti-Inflammatory Agents/*therapeutic use
Humans
Male
Prednisolone/*therapeutic use
Tachycardia, Ventricular/drug therapy
Thyrotoxicosis/*chemically induced/*drug therapy
LA - eng
N1 - Hayashi, K
Sone, T
Suzuki, T
Numaguchi, Y
Kondoh, J
Tsuboi, H
Sassa, H
Case Reports
Journal Article
Japan
Jpn Circ J. 1997 Apr;61(4):361-6. doi: 10.1253/jcj.61.361.
PY - 1997
SN - 0047-1828 (Print)
0047-1828
SP - 361-6
ST - A case of amiodarone-induced thyrotoxicosis successfully treated with
prednisolone
T2 - Jpn Circ J
TI - A case of amiodarone-induced thyrotoxicosis successfully treated with
prednisolone
VL - 61
ID - 2856
ER -
TY - JOUR
AB - Inverted T waves produced by myocardial ischemia are classically narrow and
symmetric. T-wave inversion (TWI) associated with an acute coronary syndrome (ACS)
is morphologically characterized by an isoelectric ST segment that is usually bowed
upward (ie, concave) and followed by a sharp symmetric downstroke. The terms
coronary T wave and coved T wave have been used to describe these ischemic TWIs.
Prominent, deeply inverted, and widely splayed T waves are more characteristic of
non-ACS conditions such as juvenile T-wave patterns, left ventricular hypertrophy,
acute myocarditis, Wolff-Parkinson-White syndrome, acute pulmonary embolism,
cerebrovascular accident, bundle branch block, and later stages of pericarditis.
AD - Department of Emergency Medicine, University of Virginia, Charlottesville,
VA, USA.
AN - 11992349
AU - Hayden, G. E.
AU - Brady, W. J.
AU - Perron, A. D.
AU - Somers, M. P.
AU - Mattu, A.
DA - May
DO - 10.1053/ajem.2002.32629
DP - NLM
ET - 2002/05/07
IS - 3
KW - Adult
Aged
Arrhythmias, Cardiac/*diagnosis/etiology
Bundle-Branch Block/diagnosis
Chest Pain/*diagnosis/etiology
Coronary Disease/complications/*diagnosis
Digitalis/adverse effects
Female
Humans
Male
Middle Aged
Pre-Excitation Syndromes/diagnosis
Pulmonary Embolism/complications/diagnosis
Stroke/complications/diagnosis
LA - eng
N1 - Hayden, Geoffrey E
Brady, William J
Perron, Andrew D
Somers, Michael P
Mattu, Amal
Case Reports
Journal Article
Review
United States
Am J Emerg Med. 2002 May;20(3):252-62. doi: 10.1053/ajem.2002.32629.
PY - 2002
SN - 0735-6757 (Print)
0735-6757
SP - 252-62
ST - Electrocardiographic T-wave inversion: differential diagnosis in the chest
pain patient
T2 - Am J Emerg Med
TI - Electrocardiographic T-wave inversion: differential diagnosis in the chest
pain patient
VL - 20
ID - 2722
ER -
TY - JOUR
AB - Over 70 years ago, potassium was found to have a natriuretic effect and was
used in patients with heart failure. However, it took many years for its role in
the control of blood pressure to be recognized. Recently, epidemiological and
clinical studies in man and experimental studies in animals have shown that
increasing potassium intake towers blood pressure and that communities with a high
potassium intake tend to have lower population blood pressures. Several studies
have shown an interaction between salt intake and potassium intake. However, the
recent DASH-Sodium (Dietary Approaches to Stop Hypertension) study demonstrates an
additive effect of a low salt and high potassium diet on blood pressure. Increasing
potassium intake may have other beneficial effects, for example, reducing the risk
of stroke and preventing the development of renal disease independent of its effect
on blood pressure. A high potassium intake reduces calcium excretion and could play
an important role in the management of hypercalciuria and kidney stone formation,
as well as bone demineralization. Potassium intake may also play an important role
in carbohydrate intolerance. A reduced serum potassium increases the risk of lethal
ventricular arrhythmias in those at risk, i.e. patients with ischemic heart
disease, heart failure or left ventricular hypertrophy, and increasing potassium
intake may prevent this. In this article, we address the evidence for the important
role of potassium intake in regulating blood pressure and other beneficial effects
of potassium which may be independent of and additional to its effect on blood
pressure.
AD - Blood Pressure Unit, St. George's Hospital Medical School, London, UK.
AN - 15018247
AU - He, F. J.
AU - MacGregor, G. A.
DA - Oct
DP - NLM
ET - 2004/03/17
J2 - Climacteric : the journal of the International Menopause Society
KW - Animals
Diet/standards
Female
Glucose Intolerance/*prevention & control
Humans
Kidney/drug effects
Kidney Calculi/*prevention & control
Male
Potassium, Dietary/administration & dosage/*pharmacology
Sodium, Dietary/administration & dosage/pharmacology
LA - eng
N1 - He, F J
MacGregor, G A
Journal Article
Review
England
Climacteric. 2003 Oct;6 Suppl 3:36-48.
PY - 2003
SN - 1369-7137 (Print)
1369-7137
SP - 36-48
ST - Potassium: more beneficial effects
T2 - Climacteric
TI - Potassium: more beneficial effects
VL - 6 Suppl 3
ID - 2493
ER -
TY - JOUR
AB - Atrial fibrillation and hypertension are 2 prevalent, and often coexistent,
conditions in the North American population. Their incidence increases with
advancing age, and they are responsible for considerable morbidity and mortality.
Although the relation between the 2 conditions has long been known, the treatment
of hypertension is not currently a focus in the clinical management of atrial
fibrillation. Hypertension is associated with left ventricular hypertrophy,
impaired ventricular filling, left atrial enlargement, and slowing of atrial
conduction velocity. These changes in cardiac structure and physiology favor the
development of atrial fibrillation, and they increase the risk of thromboembolic
complications. Conventional therapy of atrial fibrillation has focused on
interventions to control heart rate and rhythm and the prevention of stroke through
the use of anticoagulant medications. In patients with atrial fibrillation,
aggressive treatment of hypertension may reverse the structural changes in the
heart, reduce thromboembolic complications, and retard or prevent the occurrence of
atrial fibrillation. Specific pharmacotherapy could potentially play a major role
in the primary and secondary prevention of atrial fibrillation and its
complications.
AD - McMaster University, Hamilton, Ontario, Canada.
AN - 12781903
AU - Healey, J. S.
DA - May 22
DO - 10.1016/s0002-9149(03)00227-3
DP - NLM
ET - 2003/06/05
IS - 10a
KW - Antihypertensive Agents/therapeutic use
Atrial Fibrillation/*etiology/prevention & control
Atrial Function, Left/physiology
Atrial Premature Complexes/physiopathology
Heart Atria/drug effects/physiopathology
Humans
Hypertension/*complications/physiopathology
Hypertrophy, Left Ventricular/etiology
Risk Factors
LA - eng
N1 - Healey, Jeff S
Connolly, Stuart J
Journal Article
Review
United States
Am J Cardiol. 2003 May 22;91(10A):9G-14G. doi: 10.1016/s0002-9149(03)00227-3.
PY - 2003
SN - 0002-9149 (Print)
0002-9149
SP - 9g-14g
ST - Atrial fibrillation: hypertension as a causative agent, risk factor for
complications, and potential therapeutic target
T2 - Am J Cardiol
TI - Atrial fibrillation: hypertension as a causative agent, risk factor for
complications, and potential therapeutic target
VL - 91
ID - 2539
ER -
TY - JOUR
AB - Results of recent trials suggest that in patients with left ventricular
dysfunction, interventricular synchrony is possibly more important than
atrioventricular synchrony. In patients with AV block and conduction system
disease, alternatives to right ventricular apical pacing are therefore needed.
AN - 15145847
AU - Healey, J. S.
AU - Crystal, E.
C2 - PMC1768294
DA - Jun
DO - 10.1136/hrt.2003.022111
DP - NLM
ET - 2004/05/18
IS - 6
KW - Arrhythmias, Cardiac/physiopathology/*therapy
Equipment Design
Heart Atria
Humans
Stroke/etiology
Treatment Outcome
Ventricular Dysfunction, Left/physiopathology
Ventricular Dysfunction, Right/physiopathology
LA - eng
N1 - 1468-201x
Healey, J S
Crystal, E
Connolly, S J
Comment
Editorial
Heart. 2004 Jun;90(6):593-4. doi: 10.1136/hrt.2003.022111.
PY - 2004
SN - 1355-6037 (Print)
1355-6037
SP - 593-4
ST - Physiologic pacing: where pacing mode selection reflects the indication
T2 - Heart
TI - Physiologic pacing: where pacing mode selection reflects the indication
VL - 90
ID - 2762
ER -
TY - JOUR
AB - BACKGROUND: Several randomized trials have compared atrial-based (dual-
chamber or atrial) pacing with ventricular pacing in patients with bradycardia. No
trial has shown a mortality reduction, and only 1 small trial suggested a reduction
in stroke. The goal of this review was to determine whether atrial-based pacing
prevents major cardiovascular events. METHODS AND RESULTS: A systematic review was
performed of publications since 1980. For inclusion, trials had to compare an
atrial-based with a ventricular-based pacing mode; use a randomized, controlled,
parallel design; and have data on mortality, stroke, heart failure, or atrial
fibrillation. Individual patient data were obtained from 5 of the 8 identified
studies, representing 95% of patients in the 8 trials, and a total of 35 000
patient-years of follow-up. There was no significant heterogeneity among the
results of the individual trials. There was no significant reduction in mortality
(hazard ratio [HR], 0.95; 95% confidence interval [CI], 0.87 to 1.03; P=0.19) or
heart failure (HR, 0.89; 95% CI, 0.77 to 1.03; P=0.15) with atrial-based pacing.
There was a significant reduction in atrial fibrillation (HR, 0.80; 95% CI, 0.72 to
0.89; P=0.00003) and a reduction in stroke that was of borderline significance (HR,
0.81; 95% CI, 0.67 to 0.99; P=0.035). There was no convincing evidence that any
patient subgroup received special benefit from atrial-based pacing. CONCLUSIONS:
Compared with ventricular pacing, the use of atrial-based pacing does not improve
survival or reduce heart failure or cardiovascular death. However, atrial-based
pacing reduces the incidence of atrial fibrillation and may modestly reduce stroke.
AD - Population Health Research Institute, McMaster University, Hamilton, Ontario,
Canada, L8L 2X2. healeyj@hhsc.ca
AN - 16801463
AU - Healey, J. S.
AU - Toff, W. D.
AU - Lamas, G. A.
AU - Andersen, H. R.
AU - Thorpe, K. E.
AU - Ellenbogen, K. A.
AU - Lee, K. L.
AU - Skene, A. M.
AU - Schron, E. B.
AU - Skehan, J. D.
AU - Goldman, L.
AU - Roberts, R. S.
AU - Camm, A. J.
AU - Yusuf, S.
DA - Jul 4
DP - NLM
ET - 2006/06/28
IS - 1
J2 - Circulation
Atrial Fibrillation/complications/*prevention & control
Heart Atria
Heart Ventricles
Humans
Treatment Outcome
LA - eng
N1 - 1524-4539
Healey, Jeffrey S
Toff, William D
Lamas, Gervasio A
Andersen, Henning R
Thorpe, Kevin E
Ellenbogen, Kenneth A
Lee, Kerry L
Skene, Allan M
Schron, Eleanor B
Skehan, J Douglas
Goldman, Lee
Roberts, Robin S
Camm, A John
Yusuf, Salim
Connolly, Stuart J
Comparative Study
Journal Article
Meta-Analysis
Systematic Review
United States
Circulation. 2006 Jul 4;114(1):11-7. doi: 10.1161/CIRCULATIONAHA.105.610303. Epub
2006 Jun 26.
PY - 2006
SN - 0009-7322
SP - 11-7
ST - Cardiovascular outcomes with atrial-based pacing compared with ventricular
pacing: meta-analysis of randomized trials, using individual patient data
T2 - Circulation
TI - Cardiovascular outcomes with atrial-based pacing compared with ventricular
pacing: meta-analysis of randomized trials, using individual patient data
VL - 114
ID - 2607
ER -
TY - JOUR
AB - PURPOSE OF REVIEW: Clinical trial evidence suggests that traditional right
ventricular apical pacing may be harmful. This review summarizes the existing
evidence and outlines the major avenues of ongoing research in this field. RECENT
FINDINGS: Despite theoretical advantages of dual-chamber pacing, large randomized
trials found only a small advantage over single-chamber ventricular pacing.
Subsequent analysis of one of these trials suggested that this was due to the
tendency for dual-chamber pacemakers to produce frequent, unnecessary right
ventricular pacing. This hypothesis is supported by a prospective study among
defibrillator recipients, showing that dual-chamber pacing results in a very high
frequency of ventricular pacing and worse clinical outcomes, compared with backup
ventricular pacing. These observations have led to a renewed interest in single-
chamber atrial pacing for sinus node dysfunction, the development of new dual-
chamber pacemaker algorithms designed to minimize right ventricular pacing, and the
search for better ways to pace the ventricles in patients who require ventricular
pacing. SUMMARY: Conventional right ventricular apical pacing should be avoided
whenever possible. In patients who require ventricular pacing, ongoing research
will determine if selected-site pacing or multisite pacing improves clinical
outcomes compared with traditional right ventricular apical pacing.
AD - McMaster University, Hamilton, Canada. healeyj@hhsc.ca
AN - 17143042
AU - Healey, J. S.
AU - Yee, R.
AU - Tang, A.
DA - Jan
DO - 10.1097/HCO.0b013e32801177f2
DP - NLM
ET - 2006/12/05
IS - 1
J2 - Current opinion in cardiology
KW - Arrhythmias, Cardiac/prevention & control/*therapy
Risk Factors
Stroke
LA - eng
N1 - Healey, Jeff S
Yee, Raymond
Tang, Anthony
Journal Article
Review
United States
Curr Opin Cardiol. 2007 Jan;22(1):33-8. doi: 10.1097/HCO.0b013e32801177f2.
PY - 2007
SN - 0268-4705 (Print)
0268-4705
SP - 33-8
ST - Right ventricular apical pacing: a necessary evil?
T2 - Curr Opin Cardiol
TI - Right ventricular apical pacing: a necessary evil?
VL - 22
ID - 2590
ER -
TY - JOUR
AB - BACKGROUND: Catheter ablation of ventricular tachycardia (VT) is associated
with the risk of cerebral embolism. The origin of periprocedural brain embolism in
the setting of VT ablation is often unknown and strategies to avoid it are sparse.
The aim of this study was to assess the safety and feasibility of an endovascular
2-filter-based cerebral protection system (CPS) in left ventricular VT ablation
procedures in patients with ischemic heart disease. Furthermore, histopathological
correlates of periprocedural embolization were investigated. METHODS AND RESULTS:
In this pilot study, 11 patients with ischemic heart disease and sustained VT
underwent left ventricular catheter ablation under CPS surveillance. The placement
of the CPS was conducted before the ablation procedure via the right radial artery.
The VT ablation procedure was performed via a combined transaortic and transseptal
approach. All VTs were successfully ablated. Placement and retrieval of the CPS was
successful and safe in all cases. No periprocedural complications related to the
CPS were observed and no periprocedural transient ischemic attack or stroke
occurred. Debris captured by the CPS was detected in all patients. Histology
revealed that acute thrombus was the most common type of debris (91%), followed by
arterial wall tissue (73%) and foreign material (55%). Less frequently found were
myocardium (27%), calcification (9%), necrotic core (9%), and valve tissue (9%).
CONCLUSIONS: Cerebral protection during VT ablation seems to be safe and feasible.
Ablation procedures of VT are associated with embolization of embolic debris, which
was found in every patient.
AD - Department for Cardiology, Asklepios Klinik St. Georg, Hamburg, Germany
christian.heeger@gmx.net.
University Heart Center Luebeck, Luebeck, Germany.
Department for Cardiology, Asklepios Klinik St. Georg, Hamburg, Germany.
Asklepios Proresearch, Hamburg, Germany.
CV Path Institute, Inc., Gaithersburg, MD.
University Heart Center Bonn, Bonn, Germany.
AN - 29960991
AU - Heeger, C. H.
AU - Metzner, A.
AU - Schlüter, M.
AU - Rillig, A.
AU - Mathew, S.
AU - Tilz, R. R.
AU - Wohlmuth, P.
AU - Romero, M. E.
AU - Virmani, R.
AU - Fink, T.
AU - Reissmann, B.
AU - Lemes, C.
AU - Maurer, T.
AU - Santoro, F.
AU - Schmidt, T.
AU - Ghanem, A.
AU - Frerker, C.
AU - Kuck, K. H.
AU - Ouyang, F.
C2 - PMC6064920
DA - Jun 30
DO - 10.1161/jaha.118.009005
DP - NLM
ET - 2018/07/02
IS - 13
KW - Aged
Catheter Ablation/adverse effects/*instrumentation
*Embolic Protection Devices
Feasibility Studies
Female
Humans
Intracranial Embolism/etiology/physiopathology/*prevention & control
Male
Myocardial Ischemia/*complications/physiopathology
Pilot Projects
Prosthesis Design
Protective Factors
Risk Factors
Stroke/etiology/physiopathology/*prevention & control
Tachycardia, Ventricular/complications/physiopathology/*surgery
Time Factors
Treatment Outcome
*catheter ablation
*histopathology
*stroke prevention
*ventricular tachycardia
LA - eng
N1 - 2047-9980
Heeger, Christian-Hendrik
Metzner, Andreas
Schlüter, Michael
Rillig, Andreas
Mathew, Shibu
Tilz, Roland Richard
Wohlmuth, Peter
Romero, Maria E
Virmani, Renu
Fink, Thomas
Reissmann, Bruno
Lemes, Christine
Maurer, Tilman
Santoro, Francesco
Schmidt, Tobias
Ghanem, Alexander
Frerker, Christian
Kuck, Karl-Heinz
Ouyang, Feifan
Journal Article
J Am Heart Assoc. 2018 Jun 30;7(13):e009005. doi: 10.1161/JAHA.118.009005.
PY - 2018
SN - 2047-9980
ST - Cerebral Protection During Catheter Ablation of Ventricular Tachycardia in
Patients With Ischemic Heart Disease
TI - Cerebral Protection During Catheter Ablation of Ventricular Tachycardia in
Patients With Ischemic Heart Disease
VL - 7
ID - 2285
ER -
TY - JOUR
AB - AIM: To describe the characteristics and outcome among patients suffering in-
hospital cardiac arrest in relation to whether the arrest took place in a ward with
monitoring facilities. METHODS: All patients who suffered an in-hospital cardiac
arrest during a 4-year period in Sahlgrenska Hospital, Göteborg, Sweden and in whom
resuscitative efforts were attempted, were prospectively recorded and described in
terms of characteristics and outcome. RESULTS: Among 557 patients, 292 (53%) had a
cardiac arrest in wards with monitoring facilities. Those in a monitored location
more frequently had a confirmed or possible acute myocardial infarction (AMI) as
judged to be the cause of arrest (P < 0.0001), and the arrest was witnessed more
frequently (96 vs. 79%; P < 0.0001). Ventricular fibrillation/tachycardia was
observed more often as initial arrhythmia in monitored wards (56 vs. 44%; P =
0.006). The median interval between collapse and first defibrillation was 1 min in
monitored wards and 5 min in non-monitored wards (P < 0.0001). Among patients with
arrest in monitored wards 43.2% were discharged alive compared with 31.1% of
patients in non-monitored wards (P = 0.004). Cerebral performance category (CPC-
score) at discharge was somewhat better among survivors in monitored wards.
CONCLUSION: In a Swedish University Hospital 47% of in-hospital cardiac arrests in
which resuscitation was attempted took place in wards without monitoring
facilities. These patients differed markedly from those having arrest in wards with
monitoring facilities in terms of characteristics, interval to defibrillation and
outcome. A shortening of the interval between collapse and defibrillation in these
patients might increase survival even further.
AD - Division of Cardiology, Sahlgrenska University Hospital, Göteborg, Sweden.
johan.herlitz@hjl.gu.se
AN - 11426474
AU - Herlitz, J.
AU - Bång, A.
AU - Aune, S.
AU - Ekström, L.
AU - Lundström, G.
AU - Holmberg, S.
DA - Feb
DO - 10.1016/s0300-9572(00)00249-5
DP - NLM
ET - 2001/06/28
IS - 2
J2 - Resuscitation
KW - Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Cardiopulmonary Resuscitation/methods/mortality
*Cause of Death
Child
Female
Heart Arrest/*epidemiology/etiology/*therapy
Hospitalization
Humans
Male
Middle Aged
Monitoring, Physiologic/*methods
Myocardial Infarction/complications/epidemiology/therapy
Probability
Prospective Studies
Reference Values
Risk Factors
Sex Distribution
Survival Analysis
Sweden/epidemiology
Treatment Outcome
LA - eng
N1 - Herlitz, J
Bång, A
Aune, S
Ekström, L
Lundström, G
Holmberg, S
Comparative Study
Journal Article
Ireland
Resuscitation. 2001 Feb;48(2):125-35. doi: 10.1016/s0300-9572(00)00249-5.
PY - 2001
SN - 0300-9572 (Print)
0300-9572
SP - 125-35
ST - Characteristics and outcome among patients suffering in-hospital cardiac
arrest in monitored and non-monitored areas
T2 - Resuscitation
TI - Characteristics and outcome among patients suffering in-hospital cardiac
arrest in monitored and non-monitored areas
VL - 48
ID - 3114
ER -
TY - JOUR
AB - OBJECTIVES: To describe predictors of death during 10 years of follow-up
after coronary artery bypass grafting (CABG); to evaluate whether age interacts
with the influence of various predictors on outcome; and to compare the mortality
during 10 years after CABG with the mortality in an age- and sex-matched control
population. DESIGN: Prospective, observational study. SETTING: Department of
Thoracic and Cardiovascular Surgery at Sahlgrenska University Hospital and
Scandinavian Heart Centre in Göteborg, Sweden. PARTICIPANTS: All patients from
western Sweden who underwent CABG between 1 June 1988 and 1 June 1991 without
simultaneous valve surgery and with no previous CABG. MAIN OUTCOME MEASUREMENTS:
All-cause mortality during 10 years but more than 30 days after CABG. RESULTS: In
all, 2000 patients participated in the survey. The following factors appeared as
independent predictors of death: preoperative factors-age, history of congestive
heart failure, cerebrovascular disease, history of intermittent claudication,
current smoking, degree of left ventricular impairment, valvular disease and
duration of angina pectoris; peroperative factors-ventilator time and neurological
complications; postoperative factors-arrhythmia, requirement of digitalis and
requirement of antidiabetics. There was an interaction between age and history of
cerebrovascular disease with a stronger impact on outcome in younger patients. The
late (>30 days after CABG) 10-year mortality in the study cohort was 29.6% compared
with 25.9% in the control population (P=0.02). CONCLUSION: Among patients who
underwent CABG, 13 independent predictors for mortality were found, mainly among
preoperative factors but also among peroperative factors, postoperative
complications and medication requirement after CABG.
johan.herlitz@hjl.gu.se
AN - 15096997
AU - Herlitz, J.
AU - Brandrup-Wognsen, G.
AU - Caidahl, K.
AU - Haglid, M.
AU - Karlson, B. W.
AU - Hartford, M.
AU - Karlsson, T.
AU - Sjöland, H.
DA - May
DO - 10.1097/00019501-200405000-00005
DP - NLM
ET - 2004/04/21
IS - 3
J2 - Coronary artery disease
KW - Adult
Age Factors
Aged
Aged, 80 and over
*Cause of Death
Coronary Artery Bypass/*mortality
Coronary Disease/mortality/*surgery
Female
Humans
Male
Middle Aged
Postoperative Complications/*mortality
Risk Factors
Sex Distribution
Sweden/epidemiology
Time Factors
LA - eng
N1 - Herlitz, Johan
Brandrup-Wognsen, Gunnar
Caidahl, Kenneth
Haglid, Maria
Karlson, Björn W
Hartford, Marianne
Karlsson, Thomas
Sjöland, Helén
Journal Article
England
Coron Artery Dis. 2004 May;15(3):163-70. doi: 10.1097/00019501-200405000-00005.
PY - 2004
SN - 0954-6928 (Print)
0954-6928
SP - 163-70
ST - Predictors of death during 10 years after coronary artery bypass grafting
with particular emphasis on age
T2 - Coron Artery Dis
TI - Predictors of death during 10 years after coronary artery bypass grafting
with particular emphasis on age
VL - 15
ID - 3135
ER -
TY - JOUR
AB - AIM: To describe predictors of death during five years of follow-up after
coronary artery bypass grafting (CABG). METHODS: All patients who underwent CABG
during a period of three years in Western Sweden were included in the analysis and
were prospectively followed for five years. Mortality was related to preoperative
and peroperative factors as well as findings at physical examination and medication
4-7 days after the operation. RESULTS: In all 2121 patients underwent CABG without
simultaneous valve surgery during the study period. The overall five-year mortality
was 14.6%. The following appeared as independent predictors of death during five
years but >30 days after CABG: Current smoking (relative risk ratio 2.43 [95% Ci
1.64-3.61]) degree of impairment of left ventricular function (1.51 [1.23-1.86]), a
history of congestive heart failure (1.91 [1.35-2.701), age (1.04 [1.02-1.06])
arrhythmia 4-7 days after CABG (1.89 [1.26-2.83]), intermittent claudication (1.73
[1.19-2.52]), a history of diabetes (1.71 [1.16-2.51]), time in respirator (1.43
[1.13-1.81]), a history of cerebrovascular disease (1.72 [1.13-2.64]), treatment
with digitalis at day 4-7 (1.48 [1.07-2.05]), enzyme release (1.49 [1.03-2.16]).
CONCLUSION: Among patients who underwent CABG 11 independent predictors for
mortality were found including smoking habits at CABG, history of cardiovascular
diseases, left ventricular dysfunction, age, post operative complications and
medication after CABG.
AN - 9579812
AU - Herlitz, J.
AU - Brandrup-Wognsen, G.
AU - Haglid, M.
AU - Karlson, B. W.
AU - Hartford, M.
AU - Karlsson, T.
DA - Mar 13
DO - 10.1016/s0167-5273(97)00299-4
DP - NLM
ET - 1998/05/14
IS - 1
KW - Adult
Age Distribution
Aged
*Cause of Death
Coronary Artery Bypass/adverse effects/*mortality
Coronary Disease/mortality/*surgery
Female
Humans
Male
Middle Aged
Reoperation
Risk Factors
Sex Distribution
Sweden/epidemiology
LA - eng
N1 - Herlitz, J
Brandrup-Wognsen, G
Haglid, M
Karlson, B W
Hartford, M
Karlsson, T
Journal Article
Netherlands
Int J Cardiol. 1998 Mar 13;64(1):15-23. doi: 10.1016/s0167-5273(97)00299-4.
PY - 1998
SN - 0167-5273 (Print)
0167-5273
SP - 15-23
ST - Predictors of death during 5 years after coronary artery bypass grafting
T2 - Int J Cardiol
TI - Predictors of death during 5 years after coronary artery bypass grafting
VL - 64
ID - 3127
ER -
TY - JOUR
AB - AIM: To describe the characteristics and outcome among patients suffering
from an in-hospital cardiac arrest in women and men. METHODS: All patients who
suffered an in-hospital cardiac arrest during a 4 year period in Sahlgrenska
Hospital Göteborg, Sweden, where the cardiopulmonary resuscitation (CPR) team was
called, were recorded and described prospectively in terms of characteristics and
outcome. RESULTS: There were 557 patients suffering in-hospital cardiac arrest in
whom the CPR-team was alerted. Among them, 217 (39%) were women. Women differed
from men having a lower prevalence of earlier myocardial infarction, angina
pectoris, renal disease and a higher prevalence of rheumatic disease. In terms of
aetiology of the cardiac arrest, 47% men and 48% women were judged to have had a
confirmed or possible AMI. More men than women were found in ventricular
fibrillation/ventricular tachycardia (VF/VT) (57 vs. 41%; P<0.001), whereas more
women were found in pulseless electrical activity (30 vs. 15%; P<0.0001). Cerebral
performance categories (CPC)-score at discharge did not differ between men and
women. Among women, 36.4% survived to discharge as compared with 38.0% among men
(NS). Survival from VF/VT was 64.3% in women and 52.7% in men (NS). When correcting
for dissimilarities at baseline, the adjusted odd ratio for being discharged alive
from hospital among women as compared with men was 1.66 (95% confidence limit 1.06-
2.62; P=0.028). CONCLUSION: Thirty nine percent of patients suffering in-hospital
cardiac arrest for whom the CPR-team was alerted, were women. Women were less
frequently found in VF/VT than men. After correcting for dissimilarities at
baseline, female gender was associated with a small improvement in survival.
AD - Division of Cardiology, Sahlgrenska University Hospital, S-413 45 Göteborg,
Sweden. johan.herlitz@hjl.gu.se
AN - 11334687
AU - Herlitz, J.
AU - Rundqvist, S.
AU - Bång, A.
AU - Aune, S.
AU - Lundström, G.
AU - Ekström, L.
AU - Lindkvist, J.
DA - Apr
DO - 10.1016/s0300-9572(00)00342-7
DP - NLM
ET - 2001/05/04
IS - 1
J2 - Resuscitation
KW - Aged
Female
Heart Arrest/*epidemiology
Hospitalization
Humans
Male
Prognosis
Prospective Studies
Sex Factors
Survival Analysis
Survival Rate
Tachycardia, Ventricular/epidemiology
Time Factors
Treatment Outcome
LA - eng
N1 - Herlitz, J
Rundqvist, S
Bång, A
Aune, S
Lundström, G
Ekström, L
Lindkvist, J
Comparative Study
Journal Article
Ireland
Resuscitation. 2001 Apr;49(1):15-23. doi: 10.1016/s0300-9572(00)00342-7.
PY - 2001
SN - 0300-9572 (Print)
0300-9572
SP - 15-23
ST - Is there a difference between women and men in characteristics and outcome
after in hospital cardiac arrest?
T2 - Resuscitation
TI - Is there a difference between women and men in characteristics and outcome
after in hospital cardiac arrest?
VL - 49
ID - 2947
ER -
TY - JOUR
AB - In a systematic review and random-effects meta-analysis, we evaluated whether
obesity is associated with postoperative atrial fibrillation (POAF) in patients
undergoing cardiac operations. We selected 18 observational studies until December
2011 that excluded patients with preoperative AF (n=36,147). Obese patients had a
modest higher risk of POAF compared with nonobese (odds ratio, 1.12; 95% confidence
interval, 1.04 to 1.21; p=0.002). The association between obesity and POAF did not
vary substantially by type of cardiac operation, study design, or year of
publication. POAF was significantly associated with a higher risk of stroke,
respiratory failure, and operative death.
AD - Postgraduate School, Universidad Peruana de Ciencias Aplicadas (UPC), Lima,
Peru. adrianhernandezdiaz@gmail.com
AN - 23932258
AU - Hernandez, A. V.
AU - Kaw, R.
AU - Pasupuleti, V.
AU - Bina, P.
AU - Ioannidis, J. P.
AU - Bueno, H.
AU - Boersma, E.
AU - Gillinov, M.
DA - Sep
DO - 10.1016/j.athoracsur.2013.04.029
DP - NLM
ET - 2013/08/13
IS - 3
KW - Atrial Fibrillation/*epidemiology/etiology/physiopathology
Body Mass Index
Cardiac Surgical Procedures/*adverse effects/methods
Cause of Death
Female
Hospital Mortality/*trends
Humans
Incidence
Male
Obesity/*complications/diagnosis/surgery
Postoperative Complications/epidemiology/etiology
Prognosis
Reference Values
Risk Assessment
Survival Analysis
24
Ace
Af
ARBs
Bmi
Bsa
Cabg
Cad
Chf
Ci
Ck-mb
Copd
Cpbt
Cvd
Dm
Ecc
Edivst
Ef
Esivst
Fe
Ffp
Hdl
Iabp
Icu
Iv
Ldl
Lvef
M-h
Mi
Moose
Mantel-Haenszel
Meta-analysis of Observational Studies in Epidemiology
Na
Or
Pc
Poaf
Prisma
Pufa
Pvd
Preferred Reporting Items for Systematic Reviews and Meta-Analyses
Rbc
Rc
Rf
Sd
Se
Spb
angiotensin II receptor blockers
angiotensin-converting enzyme
atrial fibrillation
body surface area
cardiopulmonary bypass time
cerebrovascular disease
chronic obstructive pulmonary disease
confidence interval
coronary artery bypass grafting
coronary artery disease
creatinine kinase-myocardial band
diabetes mellitus
ejection fraction
end-diastolic intraventricular septum thickness
end-systolic intraventricular septum thickness
extracorporeal circulation
finite element
fresh frozen plasma
high density lipoprotein
intensive care unit
intraaortic balloon pump
inverse variance
left ventricular ejection fraction
low density lipoprotein
myocardial infarction
not available
odds ratio
peripheral vascular disease
polyunsaturated fatty acid
postoperative atrial fibrillation
prospective cohort
red blood cells
respiratory failure
retrospective cohort
standard deviation
standard error
supraventricular premature beats
LA - eng
N1 - 1552-6259
Hernandez, Adrian V
Kaw, Roop
Pasupuleti, Vinay
Bina, Pouya
Ioannidis, John P A
Bueno, Hector
Boersma, Eric
Gillinov, Marc
Cardiovascular Meta-Analyses Research Group
Comparative Study
Journal Article
Meta-Analysis
Review
Systematic Review
Netherlands
Ann Thorac Surg. 2013 Sep;96(3):1104-16. doi: 10.1016/j.athoracsur.2013.04.029.
Epub 2013 Aug 9.
PY - 2013
SN - 0003-4975
SP - 1104-16
ST - Association between obesity and postoperative atrial fibrillation in patients
undergoing cardiac operations: a systematic review and meta-analysis
TI - Association between obesity and postoperative atrial fibrillation in patients
undergoing cardiac operations: a systematic review and meta-analysis
VL - 96
ID - 3014
ER -
TY - JOUR
AB - OBJECTIVES: Ventricular arrhythmia (VA) in the setting of acute coronary
syndrome (ACS) carries an ominous prognosis; however, long-term prognosis
associated with VA in ACS in the Middle East is unknown. Accordingly, we sought to
assess the incidence, in-hospital outcomes, and 1-year mortality of in-hospital VA
in patients with ACS. METHODS AND RESULTS: The Second Gulf Registry of Acute
Coronary Events (Gulf RACE-2) is a multinational observational study of patients
with ACS, which enrolled 7930 patients. Of these, 333 (4.2%) developed VA during
hospitalization. Patients with VA were significantly older (mean age 58.3 vs. 56.8
years), and had a significantly higher rate of prior stroke/transient ischemic
attack (7.5 vs. 4.2%), smoking (36.6 vs. 35.6%), congestive heart failure (11.0 vs.
6.5%), and peripheral artery disease (6.5 vs. 1.7%), compared with patients without
VA. They had significantly less diabetes mellitus (35.4 vs. 40.3%), hypertension
(43.2 vs. 47.9%), percutaneous coronary intervention (6.1 vs. 9.4%), and
dyslipidemia (22.4 vs. 38.2%). The adjusted odds ratios for in-hospital, 30-day,
and 1-year mortality in VA complicating all ACS were 25.8, 11.1, and 7.3; ST-
elevation myocardial infarctions were 18.3, 11.7, and 6.3; and unstable angina and
non-ST elevation myocardial infarctions were 47.4, 10.3, and 18.7, respectively
(all P<0.001). CONCLUSION: In-hospital VA in patients with ACS with and without ST
elevation was associated with significantly higher in-hospital, 30-day, and 1-year
mortality. Noticeably higher long-term mortality among Middle Eastern patients with
ACS having VA compared with other reports requires further study and warrants
immediate attention.
AD - Department of Cardiac Sciences, College of Medicine, King Saud University,
Riyadh, Kingdom of Saudi Arabia. ahersi@ksu.edu.sa
AN - 23363987
AU - Hersi, A.
AU - Alhabib, K. F.
AU - Alsheikh-Ali, A. A.
AU - Sulaiman, K.
AU - Alfaleh, H. F.
AU - Alsaif, S.
AU - Al-Mahmeed, W.
AU - Asaad, N.
AU - Amin, H.
AU - Al Suwaidi, J.
DA - Mar
DO - 10.1097/MCA.0b013e32835c49ed
DP - NLM
ET - 2013/02/01
IS - 2
KW - Acute Coronary Syndrome/*mortality/therapy
Adrenergic beta-Antagonists/therapeutic use
Age Factors
Angina, Unstable/epidemiology
Angiotensin-Converting Enzyme Inhibitors/therapeutic use
Arrhythmias, Cardiac/*mortality/therapy
Coronary Angiography/statistics & numerical data
Coronary Artery Bypass/statistics & numerical data
Drug Utilization
Dyslipidemias/epidemiology
Electrocardiography
Female
Hospital Mortality
*Hospitalization
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use
Male
Middle Aged
Percutaneous Coronary Intervention/statistics & numerical data
Peripheral Arterial Disease/epidemiology
Registries
LA - eng
N1 - 1473-5830
Hersi, Ahmad
Alhabib, Khalid F
Alsheikh-Ali, Alawi A
Sulaiman, Kadhim
Alfaleh, Hussam F
Alsaif, Shukri
Al-Mahmeed, Wael
Asaad, Nidal
Amin, Haitham
Al-Motarreb, Ahmed
Al Suwaidi, Jassim
Journal Article
England
Coron Artery Dis. 2013 Mar;24(2):160-4. doi: 10.1097/MCA.0b013e32835c49ed.
PY - 2013
SN - 0954-6928
SP - 160-4
ST - Short-term and long-term mortality associated with ventricular arrhythmia in
patients hospitalized with acute coronary syndrome: findings from the Gulf RACE
registry-2
TI - Short-term and long-term mortality associated with ventricular arrhythmia in
patients hospitalized with acute coronary syndrome: findings from the Gulf RACE
registry-2
VL - 24
ID - 2409
ER -
TY - JOUR
AB - Among 509 patients referred to our Institute for Holter monitoring, between
1st September, 1982-30th October, 1983, 28 patients aged 65-90 (mean 76) were
referred for dizziness and syncope. There were 17 men and 11 women. Seven patients
had a M.I. in their past, 4 angina pectoris, 5 hypertension, 4 aortic stenosis or
aortic insufficiency or both, hemodynamically significant, one had mitral valve
prolapse (MVP) and one transient ischemic attacks (TIA). In our series 16 out of 28
patients received digoxin and antiarrhythmic drugs (quinidine, propranolol,
procainamide, Neo-gilurythmal, amiodarone), 2 of them digoxin and quinidine in full
doses and one digoxin and amiodarone. Other drugs administered to our patients
included Aldomin, Isordil, Lasix, aminophylin, cromoglycate etc. In 10 patients
(35.7%) we found complex ventricular arrhythmias (7 with M.I., 3 patients of 4 with
significant aortic valve lesion, 2 patients of 2 with left anterior hemiblock
(LAH), 1 patient with MVP, 1 patient with TIA). In another 5 patients (17.8%) we
found atrial fibrillation, fast rhythm (2 with chronic obstructive lung disease, 2
with hypertension and 1 in post M.I.) which explained their symptomatology. From
our data we conclude that the pluripathology found in old age as well as the
multimedication administered, cause a plurietiology of syncope, arrhythmias playing
an important role in its determination, in this particular age group.
AN - 3875198
AU - Hertzeanu, H.
AU - Aron, L.
DP - NLM
ET - 1985/01/01
IS - 3
J2 - Acta cardiologica
KW - Aged
Dizziness/*etiology
Female
Heart Block/complications
Heart Ventricles
Humans
Male
Syncope/*etiology
Tachycardia/complications
LA - eng
N1 - Hertzeanu, H
Aron, L
Case Reports
Journal Article
England
Acta Cardiol. 1985;40(3):291-9.
PY - 1985
SN - 0001-5385 (Print)
0001-5385
SP - 291-9
ST - Holter monitoring for dizziness and syncope in old age
T2 - Acta Cardiol
TI - Holter monitoring for dizziness and syncope in old age
VL - 40
ID - 2731
ER -
TY - JOUR
AB - Background Cardiac biomarkers and left ventricular hypertrophy ( LVH ) are
related to the risk of stroke and death in patients with atrial fibrillation. We
investigated the interrelationship between LVH and cardiac biomarkers and their
independent associations with outcomes. Methods and Results Plasma samples were
obtained at baseline in 5275 patients with atrial fibrillation in the RE - LY
(Randomized Evaluation of Long-Term Anticoagulation Therapy) trial. NT -proBNP (N-
terminal pro-B-type natriuretic peptide), cardiac troponin I and T, and growth
differentiation factor-15 were determined using high-sensitivity (hs) assays. LVH
was defined by ECG . Cox models were adjusted for baseline characteristics, LVH ,
and biomarkers. LVH was present in 1257 patients. During a median follow-up of
2.0 years, 165 patients developed a stroke and 370 died. LVH was significantly
( P<0.0001) associated with higher levels of all biomarkers in linear regression
analyses adjusting for baseline characteristics. Geometric mean ratios (95% CIs)
were as follows: NT -pro BNP , 1.32 (1.25-1.38); hs cardiac troponin I, 1.67 (1.57-
1.78); hs troponin T, 1.38 (1.32-1.44); and growth differentiation factor-15, 1.09
(1.05-1.12). For stroke, the hazard ratios (95% CIs) per 50% increase were as
follows: NT -pro BNP, 1.09 (1.00-1.19); hs cardiac troponin I, 1.09 (1.03-1.15); hs
troponin T, 1.14 (1.06-1.24); and growth differentiation factor-15, 1.22 (1.08-
1.38) (all P<0.05). For death, hazard ratios (95% CIs) were as follows: NT -pro BNP
, 1.24 (1.17-1.31); hs cardiac troponin I, 1.13 (1.10-1.17); hs troponin T, 1.28
(1.23-1.34); and growth differentiation factor-15, 1.31 (1.22-1.42) (all P<0.0001).
LVH was not significantly associated with stroke or death after adjustment for
biomarkers. Conclusions Cardiac biomarkers are significantly associated with LVH .
The prognostic value of biomarkers for stroke and death is not affected by LVH .
The prognostic information of LVH is attenuated in the presence of cardiac
biomarkers. Clinical Trial Registration URL : http://www.clinicaltrials.gov .
Unique identifier: NCT 00262600.
AD - 1 Department of Medical Sciences Cardiology Uppsala University Uppsala
Sweden.
2 Uppsala Clinical Research Center Uppsala University Uppsala Sweden.
3 Department of Medicine Hospital of Assisi Italy.
4 Department of Medicine University of Perugia Italy.
5 Department of Cardiology Maggiore Hospital Bologna Italy.
6 Department of Cardiology and Cardiovascular Pathophysiology University of Perugia
Perugia Italy.
8 Population Health Research Institute Hamilton Ontario Canada.
7 Thomas Jefferson Medical College and the Heart Center Wynnewood PA.
AN - 30651032
AU - Hijazi, Z.
AU - Verdecchia, P.
AU - Oldgren, J.
AU - Andersson, U.
AU - Reboldi, G.
AU - Mazzotta, G.
AU - Angeli, F.
AU - Eikelboom, J. W.
AU - Yusuf, S.
AU - Wallentin, L.
C2 - PMC6497355
DA - Jan 22
DO - 10.1161/jaha.118.010107
DP - NLM
ET - 2019/01/18
IS - 2
KW - Aged
Atrial Fibrillation/blood/*complications/drug therapy
Biomarkers/blood
Cause of Death/trends
Electrocardiography
Female
Follow-Up Studies
Global Health
Humans
Hypertrophy, Left Ventricular/*blood/complications/physiopathology
Incidence
Male
Prognosis
Risk Factors
Stroke/*epidemiology/etiology/prevention & control
Troponin I/*blood
Troponin T/*blood
*biomarker
*left ventricular hypertrophy
*risk prediction
LA - eng
N1 - 2047-9980
Hijazi, Ziad
Verdecchia, Paolo
Oldgren, Jonas
Andersson, Ulrika
Reboldi, Gianpaolo
Mazzotta, Giovanni
Angeli, Fabio
Eikelboom, John W
Ezekowitz, Michael D
Connolly, Stuart J
Yusuf, Salim
Wallentin, Lars
Journal Article
Multicenter Study
J Am Heart Assoc. 2019 Jan 22;8(2):e010107. doi: 10.1161/JAHA.118.010107.
PY - 2019
SN - 2047-9980
SP - e010107
ST - Cardiac Biomarkers and Left Ventricular Hypertrophy in Relation to Outcomes
in Patients With Atrial Fibrillation: Experiences From the RE - LY Trial
TI - Cardiac Biomarkers and Left Ventricular Hypertrophy in Relation to Outcomes
in Patients With Atrial Fibrillation: Experiences From the RE - LY Trial
VL - 8
ID - 2306
ER -
TY - JOUR
AB - BACKGROUND: Myocardial fibrosis is associated with poor prognosis in
nonischemic dilated cardiomyopathy (NIDCM) patients. The Selvester QRS score on 12-
lead electrocardiogram is associated with both the amount of myocardial scar and
poor prognosis in myocardial infarction patients. However, its use in NIDCM
patients is limited. We investigated the prognostic value of the QRS score and its
association with collagen volume fraction (CVF) in NIDCM patients. METHODS: We
enrolled 91 consecutive NIDCM patients (66 men, 53±13 years) without permanent
pacemakers or cardiac resynchronization therapy devices. The Selvester QRS score
was calculated by two expert cardiologists at NIDCM diagnosis. All patients were
followed up over 4.5±3.2 years. Cardiac events were defined as a composite of
cardiac death, hospitalization for worsening heart failure, and lethal arrhythmia.
We also evaluated CVF using endomyocardial biopsy samples. RESULTS: At baseline,
the left ventricular ejection fraction was 32±9%, plasma brain natriuretic peptide
level was 80 [43-237] pg/mL, and mean Selvester QRS score was 4.1 points. Twenty
cardiac events were observed (cardiac death, n=1; hospitalization for worsening
heart failure, n=16; lethal arrhythmia, n=3). Cox proportional hazard regression
analysis revealed that the Selvester QRS score was an independent determinant of
cardiac events (hazard ratio, 1.32; 95% confidence interval, 1.05-1.67; p=0.02).
The best cut-off value was determined as 3 points, with 85% sensitivity and 47%
specificity (area under the curve, 0.688, p=0.011). In Kaplan-Meier survival
analysis, the QRS score ≥3 group had more cardiac events than the QRS score <3
group (log-rank, p=0.007). Further, there was a significant positive correlation of
Selvester QRS score with CVF (r=0.46, p<0.001). CONCLUSIONS: The Selvester QRS
score can predict future cardiac events in NIDCM, reflecting myocardial fibrosis
assessed by CVF.
AD - Department of Cardiology, Nagoya University Graduate School of Medicine,
Nagoya, Japan.
Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya,
Japan. Electronic address: takaoku@med.nagoya-u.ac.jp.
Japan; Department of CKD Initiatives Internal Medicine, Nagoya University Graduate
School of Medicine, Nagoya, Japan.
Japan; Department of Clinical Laboratory, Nagoya University Hospital, Nagoya,
Japan.
AN - 29066100
AU - Hiraiwa, H.
AU - Okumura, T.
AU - Sawamura, A.
AU - Sugiura, Y.
AU - Kondo, T.
AU - Watanabe, N.
AU - Aoki, S.
AU - Ichii, T.
AU - Kitagawa, K.
AU - Kano, N.
AU - Fukaya, K.
AU - Furusawa, K.
AU - Morimoto, R.
AU - Takeshita, K.
AU - Bando, Y. K.
AU - Murohara, T.
DA - Mar
DO - 10.1016/j.jjcc.2017.09.002
DP - NLM
ET - 2017/10/27
IS - 3
KW - Adult
Aged
Cardiomyopathies/etiology
Cardiomyopathy, Dilated/complications/*physiopathology
Female
Heart Failure/*etiology
Humans
Male
Middle Aged
Prognosis
*Myocardial fibrosis
*Nonischemic dilated cardiomyopathy
*Prognosis
LA - eng
N1 - 1876-4738
Hiraiwa, Hiroaki
Okumura, Takahiro
Sawamura, Akinori
Sugiura, Yuki
Kondo, Toru
Watanabe, Naoki
Aoki, Soichiro
Ichii, Takeo
Kitagawa, Katsuhide
Kano, Naoaki
Fukaya, Kenji
Furusawa, Kenji
Morimoto, Ryota
Takeshita, Kyosuke
Bando, Yasuko K
Murohara, Toyoaki
Evaluation Study
Journal Article
Netherlands
J Cardiol. 2018 Mar;71(3):284-290. doi: 10.1016/j.jjcc.2017.09.002. Epub 2017 Oct
21.
PY - 2018
SN - 0914-5087
SP - 284-290
ST - The Selvester QRS score as a predictor of cardiac events in nonischemic
dilated cardiomyopathy
T2 - J Cardiol
TI - The Selvester QRS score as a predictor of cardiac events in nonischemic
dilated cardiomyopathy
VL - 71
ID - 2929
ER -
TY - JOUR
AB - About half of all deaths after myocardial infarction (MI) are sudden cardiac
deaths. Most of these are thought to be due to ventricular fibrillation (VF). A
number of interventions and many different antiarrhythmic agents have been
investigated, but so far only beta-blocker therapy has been found to produce
significant reductions in the risk of sudden cardiac death after MI. Reductions in
total mortality and sudden cardiac death were first reported in 1981 in 3 placebo-
controlled studies, the Norwegian Timolol Study, the American Beta-Blocker Heart
Attack Trial (BHAT), and the Göteborg Metoprolol Trial. A few years later, two very
large trials, the Metoprolol in Acute Myocardial Infarction (MIAMI) study and the
First International Study of Infarct Survival (ISIS-1), which included 6,000 and
16,000 patients, respectively, showed that beta-blocker therapy could reduce
mortality within the first 2 weeks after onset of MI. Data from 24 postinfarction
studies with long-term follow-up show an average 20% mortality reduction over 2
years. Pooled results of 28 short-term, randomized, placebo-controlled trials in
which beta blockers were given intravenously shortly after onset of MI indicate an
average 13% mortality reduction within 2 weeks. In the 16 studies in which the
sudden cardiac death rate was reported, the beneficial effect of beta blockade was
even more marked: a 34% average reduction of risk. Not all studies with beta
blockers, however, have demonstrated a significant reduction in the incidence of
sudden cardiac death. Such an effect has been clearly demonstrated only for the
more lipophilic beta blockers (timolol, metoprolol, and propranolol). Two of these
lipophilic beta blockers, metoprolol and propranolol, have also been shown to
prevent VF after MI in clinical studies. Based on observations from animal
experiments, it has been proposed that beta blockers with a high degree of
lipophilicity penetrate the brain and thereby maintain high vagal tone during
stress. A combination of direct anti-ischemic effects due to beta1 blockade and
preservation of vagal tone appears to prevent VF in these animal models. Further
clinical studies are needed to explore this hypothesis.
AD - Institute of Heart and Lung Diseases, Sahlgrenska University Hospital,
Göteborg, Sweden.
AN - 9375948
AU - Hjalmarson, A.
DA - Nov 13
DO - 10.1016/s0002-9149(97)00837-0
DP - NLM
ET - 1997/12/31
IS - 9b
Death, Sudden, Cardiac/etiology/*prevention & control
Humans
Mortality
Myocardial Infarction/complications/*drug therapy
Patient Selection
Ventricular Fibrillation/complications/prevention & control
LA - eng
N1 - Hjalmarson, A
Journal Article
Review
United States
Am J Cardiol. 1997 Nov 13;80(9B):35J-39J. doi: 10.1016/s0002-9149(97)00837-0.
PY - 1997
SN - 0002-9149 (Print)
0002-9149
SP - 35j-39j
ST - Effects of beta blockade on sudden cardiac death during acute myocardial
infarction and the postinfarction period
T2 - Am J Cardiol
TI - Effects of beta blockade on sudden cardiac death during acute myocardial
infarction and the postinfarction period
VL - 80
ID - 2996
ER -
TY - JOUR
AB - BACKGROUND: Over 90% of thrombi in atrial fibrillation (AF) originate from
the left atrial appendage (LAA). Patients with contraindications to anticoagulation
are potential candidates for LAA occlusion using the Percutaneous Left Atrial
Appendage Transcatheter Occlusion system (PLAATO, ev3 Inc., Plymouth, MN).
Transesophageal echocardiography (TEE) is typically used to guide implantation.
OBJECTIVE: This study sought to examine the utility of intracardiac
echocardiography (ICE) in providing adequate imaging guidance as an alternative to
TEE during PLAATO implantation. METHODS: The study group consisted of 10 patients
who underwent PLAATO implantation with simultaneous TEE and ICE imaging guidance.
ICE was used to perform the following tasks typically fulfilled by TEE: (1)
verification of the absence of LAA thrombus, (2) identification of the LAA ostial
dimension for device sizing, (3) guidance of transseptal puncture, (4) verification
of the delivery sheath position, and (5) confirmation of location and stability of
device before its irrecoverable release. The ability of ICE to perform these tasks
was assessed from three separate positions: the standard right atrial (RA)
position, within the coronary sinus (CS), and the right ventricular outflow tract.
RESULTS: ICE imaging of the LAA was optimal from within the CS, although imaging
from the proximal pulmonary artery provided better visualization of the distal LAA
in cross-section. The LAA dimensions, confirmation of the absence of LAA thrombus,
proper positioning of the delivery sheath, verification of location and stability
of the device obtained by ICE were consistent with findings from TEE. CONCLUSION:
Using nonconventional imaging planes, ICE imaging was able to perform the
intraprocedural functions provided by TEE during implantation of the PLAATO left
atrial appendage occlusion device.
AD - Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston,
Massachusetts 02114, USA.
AN - 17467621
AU - Ho, I. C.
AU - Neuzil, P.
AU - Mraz, T.
AU - Beldova, Z.
AU - Gross, D.
AU - Formanek, P.
AU - Taborsky, M.
AU - Niederle, P.
AU - Ruskin, J. N.
AU - Reddy, V. Y.
DA - May
DO - 10.1016/j.hrthm.2007.01.014
DP - NLM
ET - 2007/05/01
IS - 5
J2 - Heart rhythm
KW - Aged
Aged, 80 and over
Atrial Appendage/*diagnostic imaging/*surgery
Coronary Vessels/diagnostic imaging
Female
Follow-Up Studies
Humans
Ischemic Attack, Transient/etiology/prevention & control
Male
Middle Aged
Prosthesis Design
Prosthesis Implantation/*instrumentation
Pulmonary Artery/diagnostic imaging
Research Design
Thrombosis/etiology/*prevention & control
Treatment Outcome
LA - eng
N1 - Ho, Ivan C K
Neuzil, Petr
Mraz, Tomas
Beldova, Zuzana
Gross, Dan
Formanek, Pavel
Taborsky, Milos
Niederle, Petr
Ruskin, Jeremy N
Reddy, Vivek Y
Evaluation Study
Journal Article
United States
Heart Rhythm. 2007 May;4(5):567-71. doi: 10.1016/j.hrthm.2007.01.014. Epub 2007 Jan
17.
PY - 2007
SN - 1547-5271 (Print)
1547-5271
SP - 567-71
ST - Use of intracardiac echocardiography to guide implantation of a left atrial
appendage occlusion device (PLAATO)
T2 - Heart Rhythm
TI - Use of intracardiac echocardiography to guide implantation of a left atrial
appendage occlusion device (PLAATO)
VL - 4
ID - 2750
ER -
TY - JOUR
AB - In BriefBabies born with life-threatening brain blood-vessel malformations
can be helped with new heart pacemaker technology to temporarily stop the flow of
blood in their bodies during surgery, for inducing hypotension to aid in controlled
embolization.
AD - 1Division of Neurosurgery, Department of Clinical Neurosciences, University
of Calgary.
2Division of Neurology, Department of Clinical Neurosciences, University of
Calgary.
3Division of Neonatology, Department of Paediatrics, University of Calgary.
4Division of Pediatric Cardiology, Department of Pediatrics and Libin
Cardiovascular Institute of Alberta, University of Calgary.
5Division of Pediatric Anesthesia, Department of Anesthesia, and Division of
Critical Care, Department of Pediatrics, University of Calgary; and.
6Department of Radiology, University of Calgary, Alberta, Canada.
AN - 30485233
AU - Hockley, A.
AU - Tso, M. K.
AU - Almekhlafi, M. A.
AU - Lodha, A. K.
AU - Clegg, R.
AU - Luntley, J.
AU - Eesa, M.
AU - Wong, J. H.
DA - Oct 5
DO - 10.3171/2018.7.Peds1852
DP - NLM
ET - 2018/11/30
IS - 1
J2 - Journal of neurosurgery. Pediatrics
KW - Cardiac Pacing, Artificial/*methods
Central Nervous System Vascular Malformations/therapy
Cyanoacrylates/adverse effects/therapeutic use
Embolization, Therapeutic/adverse effects/*methods
Fatal Outcome
Heart Ventricles
Humans
Hypotension, Controlled/methods
Infant, Newborn
Male
Stents
Vein of Galen Malformations/diagnostic imaging/*therapy
*AVM = arteriovenous malformation
*MAP = mean arterial pressure
*NICU = neonatal intensive care unit
*RVOT = right ventricle outflow tract
*VGAM = vein of Galen aneurysmal malformation
*embolization
*n-BCA = n-butyl cyanoacrylate
*surgical technique
*vascular disorders
*vascular malformation
*vein of Galen aneurysmal malformation
*ventricular pacing
LA - eng
N1 - 1933-0715
Hockley, Aaron
Tso, Michael K
Almekhlafi, Mohammed A
Lodha, Abhay K
Clegg, Robin
Luntley, Jeremy
Eesa, Muneer
Wong, John H
Case Reports
Journal Article
United States
J Neurosurg Pediatr. 2018 Oct 5;23(1):86-91. doi: 10.3171/2018.7.PEDS1852.
PY - 2018
SN - 1933-0707
SP - 86-91
ST - Rapid cardiac ventricular pacing to facilitate embolization of vein of Galen
malformations: technical note
T2 - J Neurosurg Pediatr
TI - Rapid cardiac ventricular pacing to facilitate embolization of vein of Galen
malformations: technical note
VL - 23
ID - 3043
ER -
TY - JOUR
AB - Between 1986 and 1992, pacemakers were implanted in 307 patients with
symptoms caused by the sick sinus syndrome (SSS). 301 patients were regularly
followed up (161 men, 146 women, mean age 72.9 [27-91] years) of whom 180 had a
VVI, 65 and AAI and 58 a DDD/DDI pacemaker. Mean follow-up period was 58.3 months
for VVI-stimulated patients and 35.6 months for atrial paced patients. The data
were analysed retrospectively to ascertain whether a change in pacemaker treatment
to a more physiological system produced any lowering in the mortality rate,
incidence of permanent atrial fibrillation (AF), and thromboembolic phenomena. The
annual mortality rate of the VVI-stimulated patients was 6.9%, that of atrial paced
patients 2.8%. Age, abnormal ventricular function, survived resuscitation and
diabetes mellitus each correlated with a shortened life expectancy already at the
time of implantation, regardless of the pacemaker mode. Permanent AF was more
frequent during VVI stimulation (16% vs 7%), especially if it had been preceded by
intermittent AF (26% vs 13%). But there was no significant difference with regard
to transitory cerebral ischaemic episodes and peripheral arterial emboli (15% vs
10%). Fewer patients with atrial pacing went into heart failure (20% vs 30%). Four
patients developed a high-grade atrioventricular (a-v) block on AAI stimulation
(annual incidence 2.4%). - These observations suggest that patients with SSS should
always have atrial paced pacemaker systems. If a-v conduction is disturbed, a
bifocal pacemaker is the system of choice.
AD - I. Medizinische Klinik, Schwerpunkt Kardiologie, Klinik am Eichert,
Göppingen.
AN - 7988373
AU - Hofgärtner, F.
AU - Maier, B.
AU - Eisele, R.
AU - Hauber, J.
AU - Sigel, H.
DA - Dec 9
DO - 10.1055/s-2008-1058887
DP - NLM
ET - 1994/12/09
IS - 49
KW - Adult
Aged
Aged, 80 and over
Atrial Fibrillation/epidemiology/*prevention & control
Diabetes Mellitus/mortality
Female
Follow-Up Studies
Heart Failure/etiology/prevention & control
Humans
Incidence
Male
Middle Aged
Prognosis
Risk Factors
Sick Sinus Syndrome/complications/mortality/*therapy
Survival Rate
Thromboembolism/epidemiology/*prevention & control
Ventricular Dysfunction, Left/complications/mortality
LA - ger
N1 - Hofgärtner, F
Maier, B
Eisele, R
Hauber, J
Sigel, H
English Abstract
Journal Article
Germany
Dtsch Med Wochenschr. 1994 Dec 9;119(49):1683-9. doi: 10.1055/s-2008-1058887.
OP - Schrittmachertherapie beim Syndrom des kranken Sinusknotens. Senken
vorhofbeteiligte Schrittmachersysteme die Häufigkeit von Vorhofflimmern und
thromboembolischen Komplikationen sowie die Mortalität?
PY - 1994
SN - 0012-0472 (Print)
0012-0472
SP - 1683-9
ST - [Pacemaker therapy for the sick sinus node syndrome. Does the atrially
involved pacemaker system lower the frequency of atrial fibrillation and
thromboembolic complications as well as mortality?]
TI - [Pacemaker therapy for the sick sinus node syndrome. Does the atrially
involved pacemaker system lower the frequency of atrial fibrillation and
thromboembolic complications as well as mortality?]
VL - 119
ID - 2898
ER -
TY - JOUR
AB - AIM: To determine if early cardiac catheterization (CC) is associated with
improved survival in comatose patients who are resuscitated after cardiac arrest
when electrocardiographic evidence of ST-elevation myocardial infarction (STEMI) is
absent. METHODS: We conducted a retrospective observational study of a prospective
cohort of 754 consecutive comatose patients treated with therapeutic hypothermia
(TH) following cardiac arrest. RESULTS: A total of 269 (35.7%) patients had cardiac
arrest due to a ventricular arrhythmia without STEMI and were treated with TH. Of
these, 122 (45.4%) received CC while comatose (early CC). Acute coronary occlusion
was discovered in 26.6% of patients treated with early CC compared to 29.3% of
patients treated with late CC (p=0.381). Patients treated with early CC were more
likely to survive to hospital discharge compared to those not treated with CC
(65.6% vs. 48.6%; p=0.017). In a multivariate regression model that included study
site, age, bystander CPR, shock on admission, comorbid medical conditions,
witnessed arrest, and time to return of spontaneous circulation, early CC was
independently associated with a significant reduction in the risk of death (OR
0.35, 95% CI 0.18-0.70, p=0.003). CONCLUSIONS: In comatose survivors of cardiac
arrest without STEMI who are treated with TH, early CC is associated with
significantly decreased mortality. The incidence of acute coronary occlusion is
high, even when STEMI is not present on the postresuscitation electrocardiogram.
AD - Division of Cardiovascular Medicine, Vanderbilt University Medical Center,
Nashville, TN, United States. Electronic address: ryan.hollenbeck@vanderbilt.edu.
Division of Cardiovascular Medicine, Vanderbilt University Medical Center,
Nashville, TN, United States.
Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital,
Minneapolis, MN, United States.
Division of Cardiovascular Medicine, Lehigh Valley Hospital and Health Network,
Allentown, PA, United States.
Department of Cardiology, Ochsner Medical Center, New Orleans, LA, United States.
Department of Epidemiology and Biostatistics, University of Arizona College of
Public Health, Tucson, AZ, United States.
Department of Critical Care Services and Neuroscience Institute, Maine Medical
Center, Portland, ME, United States.
Division of Cardiovascular Medicine, University of Arizona Medical Center, Tucson,
AZ, United States.
AN - 23927955
AU - Hollenbeck, R. D.
AU - McPherson, J. A.
AU - Mooney, M. R.
AU - Unger, B. T.
AU - Patel, N. C.
AU - McMullan, P. W., Jr.
AU - Hsu, C. H.
AU - Seder, D. B.
AU - Kern, K. B.
DA - Jan
DP - NLM
ET - 2013/08/10
IS - 1
J2 - Resuscitation
KW - Aged
*Cardiac Catheterization
Coma/etiology/*mortality/*therapy
Early Medical Intervention
Female
Heart Arrest/complications/*mortality/*therapy
Humans
Male
Middle Aged
Myocardial Infarction
Survival Rate
Survivors
Acs
Cc
Cpc
Cardiac arrest
Cardiac catheterization
Ecg
Intcar
International Cardiac Arrest Registry
Pci
Rosc
ST-elevation myocardial infarction
Stemi
Th
Therapeutic hypothermia
acute coronary syndromes
cerebral performance category
electrocardiogram
percutaneous coronary intervention
return of spontaneous circulation
LA - eng
N1 - 1873-1570
Hollenbeck, Ryan D
McPherson, John A
Mooney, Michael R
Unger, Barbara T
Patel, Nainesh C
McMullan, Paul W Jr
Hsu, Chiu-Hsieh
Seder, David B
Kern, Karl B
Journal Article
Observational Study
Ireland
Resuscitation. 2014 Jan;85(1):88-95. doi: 10.1016/j.resuscitation.2013.07.027. Epub
2013 Aug 6.
PY - 2014
SN - 0300-9572
SP - 88-95
ST - Early cardiac catheterization is associated with improved survival in
comatose survivors of cardiac arrest without STEMI
T2 - Resuscitation
TI - Early cardiac catheterization is associated with improved survival in
comatose survivors of cardiac arrest without STEMI
VL - 85
ID - 3118
ER -
TY - JOUR
AB - BACKGROUND: Whether routine transesophageal echocardiography (TEE) in
addition to multidetector computed tomography (MDCT) has incremental value in
preventing periprocedural stroke before atrial fibrillation (AF) ablation is
unclear. OBJECTIVE: The purpose of this study was to evaluate whether screening
with MDCT is sufficient for preventing periprocedural stroke. METHODS: From 4
tertiary centers, we enrolled 1147 patients (902 males, age 57 ± 11 years) with
optimal anticoagulation and preserved left ventricular ejection function who had
undergone MDCT and routine TEE (group 1, n = 678) or selective TEE (group 2, n =
469) as screening tests before AF ablation. Based on a propensity score analysis, 2
groups with 412 matched pairs were created. RESULTS: Patient baseline
characteristics were comparable between the matched groups. In group 1 (n = 412),
thrombi were detected in 4 patients (1.0%) on TEE, and ablation was not performed.
These patients also showed thrombi (n = 3) or blood stasis (n = 1) on MDCT. For
thrombi detection, MDCT had sensitivity and negative predictive value of 100%. In
group 2 (n = 412), thrombi were detected in 7 patients (1.7%) on MDCT. Of these
patients , 2 (0.5%) also showed thrombi on TEE. Periprocedural stroke incidence did
not differ between the groups (0.2% each, P = 1.0). CONCLUSION: The incidence of
periprocedural stroke was low and did not differ significantly between the group
assigned to routine TEE vs selective TEE screening in AF patients undergoing
anticoagulation therapy if the patients had conditions associated with low thrombus
risk. Thus, preprocedural TEE may not be necessary before AF ablation in patients
who have undergone preprocedural cardiac MDCT that shows no evidence of left atrial
appendage thrombus.
AD - Cardiology Division, Department of Internal Medicine, Yonsei University
Medical College, Seoul, Korea.
Division of Cardiology, Gangnam Severance Hospital, Seoul, Korea.
Kyung Hee University College of Medicine, Seoul, Korea.
Bundang CHA Medical Center, CHA University, Seoul, Korea.
Biostatistics Collaboration Unit, Yonsei University Medical College, Seoul, Korea.
Department of Radiology, Yonsei University Medical College, Seoul, Korea.
Cardiology Division, Department of Internal Medicine, Yonsei University Medical
College, Seoul, Korea. Electronic address: cby6908@yuhs.ac.
AN - 24469219
AU - Hong, S. J.
AU - Kim, J. Y.
AU - Kim, J. B.
AU - Sung, J. H.
AU - Wook Kim, D.
AU - Uhm, J. S.
AU - Lee, H. J.
AU - Jin Kim, Y.
AU - Pak, H. N.
AU - Lee, M. H.
AU - Joung, B.
DA - May
DO - 10.1016/j.hrthm.2014.01.026
DP - NLM
ET - 2014/01/29
IS - 5
J2 - Heart rhythm
KW - Atrial Fibrillation/complications/*diagnostic imaging/surgery
Catheter Ablation
Female
Follow-Up Studies
Humans
Incidence
Male
Middle Aged
Multidetector Computed Tomography/*methods
Preoperative Period
Propensity Score
Stroke/epidemiology/etiology/*prevention & control
Stroke Volume
Atrial fibrillation
Computed tomography
Stroke
Transesophageal echocardiography
LA - eng
N1 - 1556-3871
Hong, Sung-Jin
Kim, Jong-Yun
Kim, Jin-Bae
Sung, Jung-Hoon
Wook Kim, Dong
Uhm, Jae-Sun
Lee, Hye-Jeong
Jin Kim, Young
Pak, Hui-Nam
Lee, Moon-Hyoung
Joung, Boyoung
Journal Article
Multicenter Study
United States
Heart Rhythm. 2014 May;11(5):763-70. doi: 10.1016/j.hrthm.2014.01.026. Epub 2014
Jan 25.
PY - 2014
SN - 1547-5271
SP - 763-70
ST - Multidetector computed tomography may be an adequate screening test to reduce
periprocedural stroke in atrial fibrillation ablation: a multicenter propensity-
matched analysis
T2 - Heart Rhythm
TI - Multidetector computed tomography may be an adequate screening test to reduce
periprocedural stroke in atrial fibrillation ablation: a multicenter propensity-
matched analysis
VL - 11
ID - 2534
ER -
TY - JOUR
AB - Ischemic stroke following acute myocardial infarction (AMI) is a rare but
serious complication due to left ventricular thrombus formation and atrial
fibrillation. Early revascularization of the culprit coronary lesion is essential.
Treatment trends may affect the risk. Conversely, the greater use of antiplatelet
agents to reduce the risk of ischemic stroke could increase the risk of hemorrhagic
stroke. The risk of stroke after AMI has decreased significantly with more use of
percutaneous coronary intervention and antithrombotic therapies in the acute
setting, and statins, antihypertensive medications, and dual antiplatelet therapy
as secondary prevention strategies.
AD - CardioVascular Center Frankfurt, Sankt Katharinen Krankenhaus, Seckbacher
Landstrasse 65, 60389 Frankfurt, Germany.
CardioVascular Center Frankfurt, Sankt Katharinen Krankenhaus, Seckbacher
Landstrasse 65, 60389 Frankfurt, Germany. Electronic address: info@cvcfrankfurt.de.
AN - 27150168
AU - Hornung, M.
AU - Franke, J.
AU - Gafoor, S.
AU - Sievert, H.
DA - May
DO - 10.1016/j.ccl.2015.12.003
DP - NLM
ET - 2016/05/07
IS - 2
J2 - Cardiology clinics
KW - Atrial Fibrillation/*complications/epidemiology
Global Health
Humans
Morbidity/trends
Myocardial Infarction/*complications/epidemiology
*Registries
Atrial fibrillation
Inflammation
Stroke
Thrombus
LA - eng
N1 - 1558-2264
Hornung, Marius
Franke, Jennifer
Gafoor, Sameer
Sievert, Horst
Journal Article
Review
Netherlands
Cardiol Clin. 2016 May;34(2):207-14. doi: 10.1016/j.ccl.2015.12.003. Epub 2016 Mar
12.
PY - 2016
SN - 0733-8651
SP - 207-14
ST - Cardioembolic Stroke and Postmyocardial Infarction Stroke
T2 - Cardiol Clin
TI - Cardioembolic Stroke and Postmyocardial Infarction Stroke
VL - 34
ID - 2308
ER -
TY - JOUR
AB - Imidapril hydrochloride (imidapril) is a long-acting, non-sulfhydryl
angiotensin-converting enzyme (ACE) inhibitor, which has been used clinically in
the treatment of hypertension, chronic congestive heart failure (CHF), acute
myocardial infarction (AMI), and diabetic nephropathy. It has the unique advantage
over other ACE inhibitors in causing a lower incidence of dry cough. After oral
administration, imidapril is rapidly converted in the liver to its active
metabolite imidaprilat. The plasma levels of imidaprilat gradually increase in
proportion to the dose, and decline slowly. The time to reach the maximum plasma
concentration (T(max)) is 2.0 h for imidapril and 9.3 h for imidaprilat. The
elimination half-lives (t(1/2)) of imidapril and imidaprilat is 1.7 and 14.8 h,
respectively. Imidapril and its metabolites are excreted chiefly in the urine. As
an ACE inhibitor, imidaprilat is as potent as enalaprilat, an active metabolite of
enalapril, and about twice as potent as captopril. In patients with hypertension,
blood pressure was still decreased at 24 h after imidapril administration. The
antihypertensive effect of imidapril was dose-dependent. The maximal reduction of
blood pressure and plasma ACE was achieved with imidapril, 10 mg once daily, and
the additional effect was not prominent with higher doses. When administered to
patients with AMI, imidapril improved left ventricular ejection fraction and
reduced plasma brain natriuretic peptide (BNP) levels. In patients with mild-to-
moderate CHF [New York Heart Association (NYHA) functional class II-III], imidapril
increased exercise time and physical working capacity and decreased plasma atrial
natriuretic peptide (ANP) and BNP levels in a dose-related manner. In patients with
diabetic nephropathy, imidapril decreased urinary albumin excretion. Interestingly,
imidapril improved asymptomatic dysphagia in patients with a history of stroke. In
the same patients it increased serum substance P levels, while the angiotensin II
receptor antagonist losartan was ineffective. These studies indicate that imidapril
is a versatile ACE inhibitor. In addition to its effectiveness in the treatment of
hypertension, CHF, and AMI, imidapril has beneficial effects in the treatment of
diabetic nephropathy and asymptomatic dysphagia. Good tissue penetration and
inhibition of tissue ACE by imidapril contributes to its effectiveness in
preventing cardiovascular complications of hypertension. The major advantages of
imidapril are its activity in the treatment of various cardiovascular diseases and
lower incidence of cough compared with some of the older ACE inhibitors.
AD - Department of Hypertension and Cardiorenal Medicine, Dokkyo University School
of Medicine, Mibu, Tochigi, Japan.
AN - 12177688
AU - Hosoya, K.
AU - Ishimitsu, T.
DA - Summer
DO - 10.1111/j.1527-3466.2002.tb00185.x
DP - NLM
ET - 2002/08/15
IS - 2
J2 - Cardiovascular drug reviews
KW - Angiotensin-Converting Enzyme
Inhibitors/pharmacokinetics/pharmacology/*therapeutic
use
Arrhythmias, Cardiac/drug therapy
Cardiomegaly/drug therapy
Cardiovascular Diseases/*drug therapy
Deglutition Disorders/drug therapy
Humans
Imidazoles/pharmacokinetics/pharmacology/*therapeutic use
*Imidazolidines
Kidney Failure, Chronic/drug therapy
Myocardial Ischemia/drug therapy
LA - eng
N1 - Hosoya, Kazuyoshi
Ishimitsu, Toshihiko
Journal Article
Review
United States
Cardiovasc Drug Rev. 2002 Summer;20(2):93-110. doi: 10.1111/j.1527-
3466.2002.tb00185.x.
PY - 2002
SN - 0897-5957 (Print)
0897-5957
SP - 93-110
ST - Protection of the cardiovascular system by imidapril, a versatile
angiotensin-converting enzyme inhibitor
T2 - Cardiovasc Drug Rev
TI - Protection of the cardiovascular system by imidapril, a versatile
angiotensin-converting enzyme inhibitor
VL - 20
ID - 3018
ER -
TY - JOUR
AB - BACKGROUND: Therapeutic hypothermia has been shown to increase survival after
out-of-hospital cardiac arrest (OHCA). The trials documenting such benefit excluded
patients with cardiogenic shock and only a few patients were treated with
percutaneous coronary intervention prior to admission to an intensive care unit
(ICU). We use therapeutic hypothermia whenever cardiac arrest patients do not wake
up immediately after return of spontaneous circulation. METHODS: This paper reports
the outcome of 50 OHCA patients with ventricular fibrillation admitted to a
tertiary referral hospital for immediate coronary angiography and percutaneous
coronary intervention when indicated. Patients were treated with intra-aortic
balloon counterpulsation (IABP) (23 of 50 patients) if indicated. All patients who
were still comatose were treated with therapeutic hypothermia at 32-34 degrees C
for 24 h before rewarming. The end-points were survival and cerebral performance
category (CPC: 1, best; 5, dead) after 6 months. RESULTS: Forty-one patients (82%)
survived until 6 months. Thirty-four patients (68%) were in CPC 1 or 2, and seven
(14%) were in CPC 3. Of the 23 patients treated with IABP, 14 (61%) survived with
CPC 1 or 2. In patients not treated with IABP, 20 patients (74%) survived with CPC
1 or 2. Forty patients (80%) developed myocardial infarction. Percutaneous coronary
intervention was performed in 36 patients (72%). CONCLUSION: In OHCA survivors who
reached our hospital, the survival rate was high and the neurological outcome
acceptable. Our results indicate that the use of therapeutic hypothermia is
justified even in haemodynamically unstable patients and those treated with
percutaneous coronary intervention.
AD - Department of Anaesthesiology and Intensive Care, Rikshospitalet, Oslo,
Norway. jan.hovdenes@rikshospitalet.no
AN - 17181536
AU - Hovdenes, J.
AU - Laake, J. H.
AU - Aaberge, L.
AU - Haugaa, H.
AU - Bugge, J. F.
DA - Feb
DO - 10.1111/j.1399-6576.2006.01209.x
DP - NLM
ET - 2006/12/22
IS - 2
J2 - Acta anaesthesiologica Scandinavica
KW - Aged
Coma/therapy
Female
Follow-Up Studies
Heart Arrest/*therapy
Humans
Hypothermia, Induced/*methods/mortality
Intra-Aortic Balloon Pumping/methods
Male
Middle Aged
Shock, Cardiogenic/therapy
Survival Rate
Treatment Outcome
LA - eng
N1 - Hovdenes, J
Laake, J H
Aaberge, L
Haugaa, H
Bugge, J F
Evaluation Study
Journal Article
England
Acta Anaesthesiol Scand. 2007 Feb;51(2):137-42. doi: 10.1111/j.1399-
6576.2006.01209.x. Epub 2006 Dec 15.
PY - 2007
SN - 0001-5172 (Print)
0001-5172
SP - 137-42
ST - Therapeutic hypothermia after out-of-hospital cardiac arrest: experiences
with patients treated with percutaneous coronary intervention and cardiogenic shock
T2 - Acta Anaesthesiol Scand
TI - Therapeutic hypothermia after out-of-hospital cardiac arrest: experiences
with patients treated with percutaneous coronary intervention and cardiogenic shock
VL - 51
ID - 3038
ER -
TY - JOUR
AB - BACKGROUND: Studies suggest that patients who undergo off-pump coronary
artery bypass grafting (OPCABG) have fewer short-term complications and use fewer
inpatient resources than do patients who undergo standard coronary artery bypass
grafting (CABG) with extracorporeal circulation. However, dissimilarity between
groups in risk factors for complications has hindered interpretation of results.
OBJECTIVES: To compare the prevalence of selected complications (atrial
fibrillation, stroke, reoperation, and bleeding) and inpatient resource utilization
(length of stay, discharge disposition, total charges) between subjects undergoing
primary isolated CABG or OPCABG who were matched with respect to key risk factors.
METHODS: Retrospective, causal-comparative survey conducted in 1 center for 18
months. Patients who underwent primary isolated CABG or OPCABG were matched for
sex, age (within 2 years), left ventricular ejection fraction (within 0.05), and
graft-patient ratio (exact match) and compared for prevalence of new-onset atrial
fibrillation, stroke, reoperation within 24 hours, and bleeding. Statistical
analysis included Wilcoxon and t tests for paired comparisons. RESULTS: The sample
(107 matched pairs) was 63% male, with a mean age of 66 (SD 9.5) years, a mean left
ventricular ejection fraction of 0.51 (SD 0.13), and a mean graft-patient ratio of
3.41 (SD 0.74). The 2 groups did not differ significantly in New York Heart
Association class (P = .43), Acute Physiology and Chronic Health Evaluation III
score (P = .22), postoperative beta-blocker use (P = .73), or comorbid conditions.
None of the complications examined differed significantly between pairs.
CONCLUSION: Patients with comparable risk profiles have similar prevalences of
selected complications after CABG and OPCABG.
AD - Department of Acute/Tertiary Care, School of Nursing, University of
Pittsburgh, Pittsburgh, Pa., USA.
AN - 15568655
AU - Hravnak, M.
AU - Hoffman, L. A.
AU - Saul, M. I.
AU - Zullo, T. G.
AU - Cuneo, J. F.
AU - Pellegrini, R. V.
C2 - PMC3655795
C6 - NIHMS467777
DA - Nov
DP - NLM
ET - 2004/12/01
IS - 6
J2 - American journal of critical care : an official publication, American
Association of Critical-Care Nurses
Aged
Atrial Fibrillation/epidemiology/etiology
Blood Transfusion/statistics & numerical data
Cardiopulmonary Bypass/*adverse effects/economics/mortality
Cohort Studies
Coronary Artery Bypass/*adverse effects/economics/*methods/mortality
Databases as Topic
Female
Humans
Male
Matched-Pair Analysis
Patient Readmission/statistics & numerical data
Reoperation/statistics & numerical data
LA - eng
N1 - 1937-710x
Hravnak, Marilyn
Hoffman, Leslie A
Saul, Melissa I
Zullo, Thomas G
Cuneo, Julie F
Pellegrini, Ronald V
Journal Article
Am J Crit Care. 2004 Nov;13(6):499-507; discussion 508.
PY - 2004
SN - 1062-3264 (Print)
1062-3264
ST - Short-term complications and resource utilization in matched subjects after
on-pump or off-pump primary isolated coronary artery bypass
T2 - Am J Crit Care
TI - Short-term complications and resource utilization in matched subjects after
on-pump or off-pump primary isolated coronary artery bypass
VL - 13
ID - 2555
ER -
TY - JOUR
AB - BACKGROUND: Catheter ablation of atrial fibrillation (AF) has become another
nonpharmacologic therapeutic option for medically refractory paroxysmal AF. Whether
this method is better than atrioventricular (AV) junction ablation plus pacing
therapy is unknown. The purpose of this study was to compare the very long-term
(longer than 4 years) clinical outcomes of the 2 methods in elderly patients (>65
years old) with medically refractory paroxysmal AF. METHODS: From January 1995 to
December 2001, 71 elderly patients with medically refractory paroxysmal AF were
included; group 1 included 32 patients with successful AV junction ablation plus
pacing therapy and group 2, 37 patients with successful catheter ablation of AF.
RESULTS: After a mean follow-up of more than 52 months, the AF was better
controlled in the group 1 patients than group 2 (100% vs 81%, P = 0.013), however,
they had a significantly higher incidence of persistent AF (69% vs 8%, P < 0.001)
and heart failure (53% vs 24%, P = 0.001). Furthermore, the incidence of ischemic
stroke and cardiac death was similar between the 2 groups. Compared with the
preablation values, a significant increase in the NYHA functional class (1.7 +/-
0.9 vs 1.4 +/- 0.7, P = 0.01) and significant decrease in the left ventricular
ejection fraction (44 +/- 8% vs 51 +/- 10%, P = 0.01) were noted in the group 1
patients, but not in the group 2 patients. CONCLUSIONS: Although AV junction
ablation plus pacing therapy better controlled the AF in elderly patients with
medically refractory paroxysmal AF, that method was associated with a higher
incidence of persistent AF and heart failure than catheter ablation of AF in the
very long-term follow-up.
AD - Division of Cardiovascular Medicine, Department of Medicine, Taipei Medical
University, School of Medicine, Taipei Wan-Fang Hospital, Taipei, Taiwan.
AN - 15877612
AU - Hsieh, M. H.
AU - Tai, C. T.
AU - Lee, S. H.
AU - Tsao, H. M.
AU - Lin, Y. K.
AU - Huang, J. L.
AU - Chan, P.
AU - Chen, Y. J.
AU - Kuo, J. Y.
AU - Tuan, T. C.
AU - Hsu, T. L.
AU - Kong, C. W.
AU - Chang, S. L.
AU - Chen, S. A.
DA - May
DO - 10.1111/j.1540-8167.2005.40632.x
DP - NLM
ET - 2005/05/10
IS - 5
KW - Aged
Atrial Fibrillation/*surgery/*therapy
*Catheter Ablation
Cerebral Infarction/epidemiology
Female
Follow-Up Studies
Humans
Incidence
Male
Recurrence
Treatment Outcome
LA - eng
N1 - Hsieh, Ming-Hsiung
Tai, Ching-Tai
Lee, Shih-Huang
Tsao, Huan-Ming
Lin, Yung-Kuo
Huang, Jin-Long
Chan, Paul
Chen, Yi-Jen
Kuo, Jen-Yuan
Tuan, Ta-Chuan
Hsu, Tsui-Lieh
Kong, Chi-Woon
Chang, Shih-Lin
Chen, Shih-Ann
Comparative Study
Journal Article
United States
J Cardiovasc Electrophysiol. 2005 May;16(5):457-61. doi: 10.1111/j.1540-
8167.2005.40632.x.
PY - 2005
SN - 1045-3873 (Print)
1045-3873
SP - 457-61
ST - Catheter ablation of atrial fibrillation versus atrioventricular junction
ablation plus pacing therapy for elderly patients with medically refractory
paroxysmal atrial fibrillation
TI - Catheter ablation of atrial fibrillation versus atrioventricular junction
ablation plus pacing therapy for elderly patients with medically refractory
paroxysmal atrial fibrillation
VL - 16
ID - 2742
ER -
TY - JOUR
AB - Left atrial (LA) strain can reflect LA remodeling and is reduced in atrial
fibrillation (AF) patients with prior stroke. This study sought to examine the
ability of LA strain in predicting subsequent stroke event in AF and also evaluated
whether E/LA strain could predict cardiovascular (CV) events in these patients. In
190 persistent AF patients, we performed comprehensive echocardiography with
assessment of LA strain. There were 69 CV events including 19 CV death, 32
hospitalizations for heart failure, 3 myocardial infarctions, and 15 strokes during
an average follow-up of 29 months. Multivariate analysis showed old age, chronic
heart failure, increased left ventricular (LV) mass index, and increased E/LA
strain were associated with CV events and decreased LA strain was associated with
subsequent stroke event. The addition of E/LA strain and LA strain to a model
containing CHA2DS2-VASc score and LV function significantly improved the values in
predicting CV events and subsequent stroke event, respectively. In conclusion, E/LA
strain and LA strain were respectively useful in predicting CV events and
subsequent stroke event in AF. E/LA strain and LA strain could provide incremental
values for CV outcome and subsequent stroke outcome prediction over conventional
clinical and echocardiographic parameters in AF, respectively.
University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung,
Taiwan.
Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung
Medical University, Kaohsiung, Taiwan.
AN - 26833057
AU - Hsu, P. C.
AU - Lee, W. H.
AU - Chu, C. Y.
AU - Lee, H. H.
AU - Lee, C. S.
AU - Yen, H. W.
AU - Lin, T. H.
AU - Voon, W. C.
AU - Lai, W. T.
AU - Sheu, S. H.
AU - Su, H. M.
C2 - PMC4735288
DA - Feb 1
DO - 10.1038/srep17318
DP - NLM
ET - 2016/02/03
J2 - Scientific reports
KW - Aged
Aged, 80 and over
*Atrial Fibrillation/diagnostic imaging/mortality/physiopathology
*Atrial Remodeling
*Echocardiography
Female
Follow-Up Studies
Heart Atria/diagnostic imaging/physiopathology
Humans
Male
Middle Aged
Stroke/diagnostic imaging/etiology/mortality/physiopathology
Survival Rate
LA - eng
N1 - 2045-2322
Hsu, Po-Chao
Lee, Wen-Hsien
Chu, Chun-Yuan
Lee, Hung-Hao
Lee, Chee-Siong
Yen, Hsueh-Wei
Lin, Tsung-Hsien
Voon, Wen-Chol
Lai, Wen-Ter
Sheu, Sheng-Hsiung
Su, Ho-Ming
Clinical Trial
Journal Article
Observational Study
Sci Rep. 2016 Feb 1;6:17318. doi: 10.1038/srep17318.
PY - 2016
SN - 2045-2322
SP - 17318
ST - Prognostic role of left atrial strain and its combination index with
transmitral E-wave velocity in patients with atrial fibrillation
T2 - Sci Rep
TI - Prognostic role of left atrial strain and its combination index with
transmitral E-wave velocity in patients with atrial fibrillation
VL - 6
ID - 2408
ER -
TY - JOUR
AB - BACKGROUND: Tricuspid regurgitation pressure gradient (TRPG) is reportedly a
predictor of cardiovascular (CV) mortality in patients without atrial fibrillation
(AF); its relationship with cardiac outcomes in patients with AF has never been
evaluated. This study aimed to examine the ability of TRPG to predict CV events and
all-cause mortality in patients with AF. MATERIALS AND METHODS: Comprehensive
echocardiography was performed in 155 patients with persistent AF. Combined CV
events were defined as CV mortality, stroke and hospitalization for heart failure.
RESULTS: During an average follow-up period of 27 months, 57 CV events and 31 all-
cause deaths occurred. According to multivariate analysis, predictors of CV events
included diuretic use, decreased left ventricular ejection fraction (LVEF),
increased ratio of transmitral E velocity (E) to early diastolic mitral annular
velocity (E') and TRPG. Predictors of all-cause mortality included old age,
decreased LVEF, increased E/E' and TRPG. Notably, the addition of TRPG to a model
containing clinical significant parameters, LVEF and E/E' significantly improved
the values in predicting adverse CV events and all-cause mortality. CONCLUSIONS:
The TRPG is not only a useful predictor of adverse CV events and all-cause
mortality in patients with AF, it may also provide additional prognostic values for
CV outcome and all-cause mortality over conventional parameters in such patients.
AD - Department of Internal Medicine, Kaohsiung Medical University Hospital,
Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China; Faculty of
Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan,
Republic of China.
Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung
Medical University, Kaohsiung, Taiwan, Republic of China; Department of Internal
Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University,
Kaohsiung, Taiwan, Republic of China; Faculty of Medicine, College of Medicine,
Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China.
Medical University, Kaohsiung, Taiwan, Republic of China.
Kaohsiung, Taiwan, Republic of China.
Kaohsiung, Taiwan, Republic of China; Faculty of Medicine, College of Medicine,
Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China. Electronic
address: cobeshm@seed.net.tw.
AN - 30219157
AU - Hsu, P. C.
AU - Lee, W. H.
AU - Chu, C. Y.
AU - Tsai, W. C.
AU - Lee, H. H.
AU - Lee, C. S.
AU - Yen, H. W.
AU - Lin, T. H.
AU - Voon, W. C.
AU - Lai, W. T.
AU - Sheu, S. H.
AU - Su, H. M.
DA - Aug
DO - 10.1016/j.amjms.2018.05.007
DP - NLM
ET - 2018/09/17
IS - 2
J2 - The American journal of the medical sciences
KW - Aged
Aged, 80 and over
*Atrial Fibrillation/complications/diagnostic imaging/mortality/physiopathology
*Blood Pressure
*Echocardiography
Female
Heart Failure/diagnostic imaging/etiology/mortality/physiopathology
*Hospital Mortality
Humans
Male
Middle Aged
*Models, Cardiovascular
Prospective Studies
Stroke/diagnostic imaging/etiology/mortality/physiopathology
Stroke Volume
*Tricuspid Valve Insufficiency/diagnostic
imaging/etiology/mortality/physiopathology
*Cardiovascular events
*Tricuspid regurgitation pressure gradient
LA - eng
N1 - 1538-2990
Hsu, Po-Chao
Lee, Wen-Hsien
Chu, Chun-Yuan
Tsai, Wei-Chung
Lee, Hung-Hao
Lee, Chee-Siong
Yen, Hsueh-Wei
Lin, Tsung-Hsien
Voon, Wen-Chol
Lai, Wen-Ter
Sheu, Sheng-Hsiung
Su, Ho-Ming
Clinical Trial
Journal Article
Observational Study
United States
Am J Med Sci. 2018 Aug;356(2):147-151. doi: 10.1016/j.amjms.2018.05.007. Epub 2018
May 22.
PY - 2018
SN - 0002-9629
SP - 147-151
ST - Tricuspid Regurgitation Pressure Gradient as a Useful Predictor of Adverse
Cardiovascular Events and All-Cause Mortality in Patients With Atrial Fibrillation
T2 - Am J Med Sci
TI - Tricuspid Regurgitation Pressure Gradient as a Useful Predictor of Adverse
Cardiovascular Events and All-Cause Mortality in Patients With Atrial Fibrillation
VL - 356
ID - 2452
ER -
TY - JOUR
AB - OBJECTIVE: The aim of this study is to identify the risk factors in Chinese
with nonvalvular atrial fibrillation and stroke, using case-control methodology.
METHODS: A total of 4 511 adult patients diagnosed with atrial fibrillation were
identified from 18 hospitals over a 2-year period. There were 1 086 patients with
rheumatic valvular atrial fibrillation and 3 425 patients with nonvalvular atrial
fibrillation. Among the nonvalvular atrial fibrillation patients, 827 had ischemic
stroke. The data of the patients having nonvalvular atrial fibrillation with stroke
was compared with those having nonvalvular atrial fibrillation without stroke (n =
2 598). The effect of each variable on stroke was assessed with a logistic
regression analysis. RESULTS: The studied cases with stroke and controls without
stroke were similar in terms of percentage with sex, a past history of congestive
heart failure, myocardial infarction, and mean left atrial size. Cases were
significantly older than controls (73.3 +/- 9.2 vs. 68.2 +/- 12.3, P < 0.001) and
more likely to have a history of hypertension (71.0% versus 51.6%, P < 0.001) and
diabetes (17.9% vs. 11.1%, P = 0.001). There is strong evidence that left atrial
(LA) thrombi make AF patients highly risky for stroke. In multivariate analysis,
age > or = 75 (OR 1.76; 95% CI 1.08 approximately 2.98), history of hypertension
(OR 1.52; 95% CI 1.28 approximately 1.80), diabetes (OR 1.39; 95% CI 1.11
approximately 1.76), high systolic blood pressure (OR 1.71; 95% CI 1.21
approximately 2.28), LA thrombi (OR 2.77; 95% CI 1.25 approximately 6.13) were
independently associated with stroke. The lack of the association between left
ventricular dysfunction and stroke is due to the relatively incorrect diagnosis of
heart failure in the context of atrial fibrillation. CONCLUSIONS: Our analysis
suggests that old age, hypertension, diabetes, high systolic blood pressure and LA
thrombi detected with echocardiography are independent risk factors, which should
be considered when decision of long-term anticoagulation therapy to prevent stroke
with nonvalvular atrial fibrillation is to be made.
AD - Cardiology Department of Renmin Hospital, Peking University, Beijing 100044,
China.
AN - 12816695
AU - Hu, D. Y.
AU - Sun, Y. H.
AU - Zhou, Z. Q.
AU - Li, K. B.
AU - Ni, Y. B.
AU - Yang, G.
AU - Sun, S. H.
AU - Li, L.
DA - Mar
DP - NLM
ET - 2003/06/21
IS - 3
KW - Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Atrial Fibrillation/*complications/epidemiology
China/epidemiology
Female
Humans
Hypertension/complications/epidemiology
Male
Middle Aged
Risk Factors
Thrombosis/complications/epidemiology
LA - chi
N1 - Hu, Da-yi
Sun, Yi-hong
Zhou, Zi-qiang
Li, Kui-bao
Ni, Yong-bin
Yang, Guang
Sun, Shu-hong
Li, Lei
English Abstract
Journal Article
China
Zhonghua Nei Ke Za Zhi. 2003 Mar;42(3):157-61.
PY - 2003
SN - 0578-1426 (Print)
0578-1426
SP - 157-61
ST - [Risk factors for stroke in Chinese with non valvular atrial fibrillation: a
case-control study]
TI - [Risk factors for stroke in Chinese with non valvular atrial fibrillation: a
case-control study]
VL - 42
ID - 2733
ER -
TY - JOUR
AB - OBJECTIVES: The aim of the study was to examine the association of
CHADS2/CHA2DS2-VASc scores with left atrial thrombus (LAT) and spontaneous
echocardiographic contrast (SEC) in non-anticoagulated nonvalvular atrial
fibrillation (NVAF) spontaneous patients, and to develop a new scoring system for
LAT/SEC prediction. METHODS: Consecutive non-anticoagulated NVAF patients with or
without LAT/SEC by transesophageal echocardiography were identified in the
Guangdong General Hospital. RESULTS: Among 2,173 patients, the prevalence of
LAT/SEC was 4.9%. Both predictive values of CHADS2 and CHA2DS2-VASc scores for the
presence of LAT/SEC were low-to-moderate (receiver operating characteristic [ROC] =
0.591 and 0.608, respectively, p = 0.90). By multivariate analysis, non-paroxysmal
AF, decreased left ventricular ejection fraction, and left atrial enlargement were
positively associated with LAT/SEC, while CHADS2/CHA2DS2VASc scores were not. A new
scoring system based on these 3 factors above significantly improved the
discrimination for LAT/SEC (ROC = 0.792). CONCLUSIONS: CHADS2/CHA2DS2-VASc scores
had limited value in predicting LAT/SEC; a new scoring system that combines AF type
and echocardiographic parameters may better predict LAT/SEC as a surrogate for
cardioembolic risk in NVAF patients.
AD - Department of Geriatrics, Guangdong General Hospital, Institute of
Geriatrics, Guangdong Academy of Medical Sciences, Guangzhou, China.
Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Province
Key Laboratory of South China Structural Heart disease, Guangdong General Hospital,
Guangdong Academy of Medical Sciences, Guangzhou, China.
Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
School of Public Health, Sun Yat-sen University, Guangzhou, China.
School of Public Health, The University of Hong Kong, Hong Kong, China.
AN - 29920487
AU - Huang, J.
AU - Liao, H. T.
AU - Fei, H. W.
AU - Xue, Y. M.
AU - Zhang, L.
AU - Lin, Q. W.
AU - Ren, S. Q.
AU - Zhan, X. Z.
AU - Fang, X. H.
AU - Zheng, M. R.
AU - Wu, S. L.
AU - Xu, L.
DO - 10.1159/000489390
DP - NLM
ET - 2018/06/20
IS - 2
J2 - Cardiology
KW - Aged
Aged, 80 and over
Atrial Fibrillation/complications/diagnostic imaging
Atrial Function, Left
China/epidemiology
Contrast Media
Heart Diseases
Humans
Male
Middle Aged
Risk Factors
Stroke/etiology
Thromboembolism/*diagnostic imaging/*epidemiology
Thrombosis/complications/diagnostic imaging/*epidemiology
*CHA2DS2-VASc score
*CHADS2 score
*Left atrial thrombus
*Nonvalvular atrial fibrillation
*Spontaneous echocardiographic contrast
LA - eng
N1 - 1421-9751
Huang, Jun
Liao, Hong-Tao
Fei, Hong-Wen
Xue, Yu-Mei
Zhang, Li
Lin, Qiong-Wen
Ren, Si-Qi
Zhan, Xian-Zhang
Fang, Xian-Hong
Zheng, Mu-Rui
Wu, Shu-Lin
Xu, Lin
Journal Article
Switzerland
Cardiology. 2018;140(2):87-95. doi: 10.1159/000489390. Epub 2018 Jun 19.
PY - 2018
SN - 0008-6312
SP - 87-95
ST - Association of Thromboembolic Risk Score with Left Atrial Thrombus and
Spontaneous Echocardiographic Contrast in Non-Anticoagulated Nonvalvular Atrial
Fibrillation Patients
T2 - Cardiology
TI - Association of Thromboembolic Risk Score with Left Atrial Thrombus and
Spontaneous Echocardiographic Contrast in Non-Anticoagulated Nonvalvular Atrial
Fibrillation Patients
VL - 140
ID - 2545
ER -
TY - JOUR
AB - The main mechanism of the CHADS(2) and CHA(2)DS(2)-VASc scores to predict
stroke in nonvalvular atrial fibrillation (NVAF) is still controversial. We
evaluated the association of the CHADS(2) and CHA(2)DS(2)-VASc scores with left
atrial thrombus (LAT) as detected by transesophageal echocardiographic (TEE) and
compared the predictive ability of these risk stratification schemes with
nonvalvular atrial fibrillation (NVAF). Data from 2,695 consecutive NVAF patients
in whom TEE was performed for screening LAT from July 2007 to February 2014 were
analyzed. Only 3% of the subjects had LAT. Presence of LAT was not significantly
associated with either CHADS(2) (P = 0.07) or CHA(2)DS(2)-VASc score (P = 0.12).
The area under the curve (AUC) concerning LAT prediction using CHADS(2) and
CHA(2)DS(2)-VASc was 0.574 and 0.569, respectively. A composition model includes
previous stroke or transient ischemic attack, nonparoxysmal AF, moderate to severe
left ventricular systolic dysfunction, left atrial enlargement, and cardiomyopathy
which improved the discrimination significantly (AUC = 0.743). In our cohort, both
CHADS(2) and CHA(2)DS(2)-VASc scores were of limited value for predicting LAT in
patients with NVAF. This questions the CHADS(2)/CHA(2)DS(2)-VASc score predicting
stroke mainly through the mechanism of cardiogenic embolism. A scoring scheme
combining clinical and echocardiographic parameters may better predict LAT as a
surrogate for cardioembolic risk in NVAF patients.
AD - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong
General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
School of Public Health, Sun Yat-sen University, Guangdong, China; School of Public
Health, The University of Hong Kong, Pokfulam, Hong Kong.
AN - 28373985
AU - Huang, J.
AU - Wu, S. L.
AU - Xue, Y. M.
AU - Fei, H. W.
AU - Lin, Q. W.
AU - Ren, S. Q.
AU - Liao, H. T.
AU - Zhan, X. Z.
AU - Fang, X. H.
AU - Xu, L.
C2 - PMC5360946
DO - 10.1155/2017/6839589
DP - NLM
ET - 2017/04/05
J2 - BioMed research international
KW - Aged
Asian Continental Ancestry Group
Atrial Fibrillation/complications/diagnosis/*physiopathology
Echocardiography
Female
Humans
Male
Middle Aged
*Prognosis
Risk Factors
Stroke/complications/diagnosis/*physiopathology
Thrombosis/complications/diagnosis/*physiopathology
LA - eng
N1 - 2314-6141
Huang, J
Wu, S L
Orcid: 0000-0001-8276-7974
Xue, Y M
Fei, H W
Lin, Q W
Ren, S Q
Liao, H T
Zhan, X Z
Fang, X H
Xu, L
Journal Article
Biomed Res Int. 2017;2017:6839589. doi: 10.1155/2017/6839589. Epub 2017 Mar 8.
PY - 2017
SN - 2314-6133 (Print)
SP - 6839589
ST - Association of CHADS(2) and CHA(2)DS(2)-VASc Scores with Left Atrial Thrombus
with Nonvalvular Atrial Fibrillation: A Single Center Based Retrospective Study in
a Cohort of 2695 Chinese Subjects
T2 - Biomed Res Int
TI - Association of CHADS(2) and CHA(2)DS(2)-VASc Scores with Left Atrial Thrombus
with Nonvalvular Atrial Fibrillation: A Single Center Based Retrospective Study in
a Cohort of 2695 Chinese Subjects
VL - 2017
ID - 2554
ER -
TY - JOUR
AB - Torsade de pointes (TdP) is a life-threatening polymorphic ventricular
tachycardia that is related to QT prolongation. Although QT prolongation is
commonly seen in acute stroke, TdP is rare. We report the case of a 78-year-old
woman with ischemic stroke who presented with TdP as the initial manifestation of
early neurologic deterioration. We hypothesized that an increase in intracranial
pressure may result in neurohormonal activation, QT prolongation, and then
myocardial damage, leading to TdP. We highlight that new onset of TdP in a patient
with stroke may reflect neurologic deterioration, requiring further evaluation and
specific intervention.
AD - Department of Internal Medicine, Division of Cardiology, Armed Forces Taoyuan
General Hospital, Taoyuan, Taiwan; Department of Internal Medicine, Division of
Cardiology, Tri-Service General Hospital, National Defense Medical Center, Taipei,
Taiwan.
AN - 24070981
AU - Huang, L. Y.
AU - Lin, W. S.
AU - Lin, W. Y.
AU - Cheng, C. C.
AU - Cheng, S. M.
AU - Tsai, T. N.
DA - Dec
DO - 10.1016/j.ajem.2013.07.007
DP - NLM
ET - 2013/09/28
IS - 12
KW - Aged
Brain Ischemia/*complications/diagnostic imaging
Disease Progression
Electrocardiography
Female
Humans
Torsades de Pointes/*etiology
LA - eng
N1 - 1532-8171
Huang, Li-Yen
Lin, Wei-Shiang
Lin, Wen-Yu
Cheng, Cheng-Chung
Cheng, Shu-Meng
Tsai, Tsung-Neng
Case Reports
Journal Article
United States
Am J Emerg Med. 2013 Dec;31(12):1719.e5-7. doi: 10.1016/j.ajem.2013.07.007. Epub
2013 Sep 23.
PY - 2013
SN - 0735-6757
SP - 1719.e5-7
ST - Torsade de pointes indicates early neurologic damage in acute ischemic stroke
T2 - Am J Emerg Med
TI - Torsade de pointes indicates early neurologic damage in acute ischemic stroke
VL - 31
ID - 2681
ER -
TY - JOUR
AB - The risk of stroke in atrial fibrillation (AF) needs to be assessed in each
patient to determine the clinical and cost-effectiveness of thromboprophylaxis,
with the aim of appropriate use of antithrombotic therapy. To achieve this, stroke
risk factors in AF populations need to be identified and stroke risk stratification
models have been devised on the basis of these risk factors. In this article, we
firstly provide a systematic review of studies examining the attributable stroke
risk of various clinical, demographic and echocardiographic patient characteristics
in AF populations. Secondly, we performed a systematic review of published stroke
risk stratification models, in terms of the results of the review of stroke risk
factors and their ability to accurately discriminate between different levels of
stroke risk. Thirdly, we review the health economic evidence relating to the cost-
effectiveness of anticoagulation and antiplatelet therapy as thromboprophylaxis in
AF patients. The studies included in the systematic review of stroke risk factors
identified history of stroke or TIA, increasing age, hypertension and structural
heart disease (left-ventricular dysfunction or hypertrophy) to be good predictors
of stroke risk in AF patients. The evidence regarding diabetes mellitus, gender and
other patient characteristics was less consistent. Three stroke risk stratification
models were identified that were able to discriminate between different categories
of stroke risk to at least 95% accuracy. Few models had addressed the cumulative
nature of risk factors where a combination of risk factors would confer a greater
risk than either factor alone. In patients at high risk of stroke, anticoagulation
is cost effective, but not for those with a low risk of stroke. With the evidence
available for stroke risk factors and the various alternative stroke risk
stratification models, a review of these models in terms of the evidence on which
they are devised and their performance in representative AF populations is
important. The appropriate administration of thromboprophylaxis in AF patients
would need to balance the risks and benefits of antithrombotic therapy with its
cost-effectiveness.
AD - National Collaborating Center for Chronic Conditions, Royal College of
Physicians, London, UK.
AN - 18278178
AU - Hughes, M.
AU - Lip, G. Y.
DA - Feb
DO - 10.1160/th07-08-0508
DP - NLM
ET - 2008/02/19
IS - 2
J2 - Thrombosis and haemostasis
KW - Age Factors
Aged
Algorithms
Anticoagulants/adverse effects/economics/*therapeutic use
Atrial Fibrillation/complications/*drug therapy/economics
Cost-Benefit Analysis
Diabetes Complications/drug therapy/etiology
Drug Costs
Female
Fibrinolytic Agents/adverse effects/economics/*therapeutic use
Health Care Costs
Humans
Male
Patient Selection
Platelet Aggregation Inhibitors/adverse effects/economics/*therapeutic use
Research Design
Risk Assessment
Risk Factors
Sex Factors
Smoking/adverse effects
Stroke/economics/etiology/*prevention & control
Thromboembolism/complications/economics/etiology/*prevention & control
Treatment Outcome
LA - eng
N1 - Hughes, Michael
Lip, Gregory Y H
Guideline Development Group, National Clinical Guideline for Management of Atrial
Fibrillation in Primary and Secondary Care, National Institute for Health and
Clinical Excellence
Journal Article
Review
Systematic Review
Germany
Thromb Haemost. 2008 Feb;99(2):295-304. doi: 10.1160/TH07-08-0508.
PY - 2008
SN - 0340-6245 (Print)
0340-6245
SP - 295-304
ST - Stroke and thromboembolism in atrial fibrillation: a systematic review of
stroke risk factors, risk stratification schema and cost effectiveness data
T2 - Thromb Haemost
TI - Stroke and thromboembolism in atrial fibrillation: a systematic review of
stroke risk factors, risk stratification schema and cost effectiveness data
VL - 99
ID - 2514
ER -
TY - JOUR
AB - BACKGROUND: Persistent and long-standing persistent atrial fibrillation (AF)
often requires extensive and/or repeat radiofrequency (RF) ablation procedures.
OBJECTIVE: The Tailored Treatment of Persistent Atrial Fibrillation (TTOP-AF) study
assessed the effectiveness and safety of the phased RF system in a randomized
controlled comparison of medical therapy against phased RF ablation for the
management of persistent and long-standing persistent AF. METHODS: Patients who had
failed at least 1 antiarrhythmic drug (AAD) were randomized (2:1) to ablation
management (AM) or medical management (MM). AM patients were allowed up to 2
ablations. Index and retreatment procedures consisted of pulmonary vein isolation
and ablation of complex fractionated atrial electrograms. MM patients received AAD
changes and/or cardioversion. The primary end points of the TTOP-AF study included
chronic effectiveness and safety at 6 months and acute safety within 7 days of
ablation. RESULTS: At 6 months, a greater proportion of AM patients achieved
effectiveness off AAD (77 of 138 [55.8%]) compared to MM patients (19 of 72
[26.4%]) (P < .0001). Acutely, 92.8% (128/138) of the procedures were successful
while 12.3% (17/138) experienced a serious procedure and/or device-related adverse
event. The predefined acute safety end point was not met. The proportion of
patients with chronic safety events did not differ significantly between groups.
CONCLUSIONS: Catheter ablation of persistent/long-standing persistent AF with the
phased RF ablation system is effective with greater reduction of AF compared with
MM. More intense anticoagulation strategies, careful attention to catheter
placement relative to the pulmonary vein ostia, and elimination of electrode
interaction are expected to reduce the risk of stroke, pulmonary vein stenosis, and
asymptomatic cerebral emboli.
AD - The Ohio State University, Columbus, Ohio. Electronic address:
John.Hummel@osumc.edu.
Brigham and Women's Hospital, Boston, Massachusetts.
Iowa Heart Center, Des Moines, Iowa.
Emory Crawford Long Hospital, Atlanta, Georgia.
Texas Heart Institute at St. Luke's Episcopal Hospital, Houston, Texas.
St. Luke's Hospital, Mayo Clinic, Jacksonville, Florida.
Genesis Medical Center, Davenport, Iowa.
Piedmont Hospital, Atlanta, Georgia.
Austin Heart, Austin, Texas.
The John Hopkins Medical Institute, Baltimore, Maryland.
St. Antonius Ziekenhuis, Nieuwegein, The Netherlands.
AN - 24239841
AU - Hummel, J.
AU - Michaud, G.
AU - Hoyt, R.
AU - DeLurgio, D.
AU - Rasekh, A.
AU - Kusumoto, F.
AU - Giudici, M.
AU - Dan, D.
AU - Tschopp, D.
AU - Calkins, H.
AU - Boersma, L.
DA - Feb
DO - 10.1016/j.hrthm.2013.11.009
DP - NLM
ET - 2013/11/19
IS - 2
J2 - Heart rhythm
KW - Adolescent
Adult
Aged
Atrial Fibrillation/drug therapy/*surgery
Catheter Ablation/adverse effects/*methods
Female
Humans
Male
Middle Aged
Retreatment
Stroke/etiology
Treatment Outcome
Aad
Ace
Af
Am
Ablation
Atrial fibrillation
Cfae
Complex Fractionated Atrial Electrogram
Dccv
Fda
Food and Drug Administration
Inr
Itt
International normalized ratio
La
Lmwh
Lvef
Maac
Masc
Mm
Oat
Pv
Pvac
Persistent
Phased RF
Rf
Sr
Tee
Ttop
Ttop-af
Tailored Treatment of Persistent Atrial Fibrillation
ablation management
antiarrhythmic drug
asymptomatic cerebral embolus
direct current cardioversion
intention to treat
left atrial
left ventricular ejection fraction
low-molecular weight heparin
medical management
multiarray ablation catheter
multiarray septal catheter
oral anticoagulation therapy
pulmonary vein
pulmonary vein ablation catheter
radiofrequency
sinus rhythm
transesophageal echocardiography
LA - eng
N1 - 1556-3871
Hummel, John
Michaud, Gregory
Hoyt, Robert
DeLurgio, David
Rasekh, Abdi
Kusumoto, Fred
Giudici, Michael
Dan, Dan
Tschopp, David
Calkins, Hugh
Boersma, Lucas
TTOP-AF Investigators
Comparative Study
Journal Article
United States
Heart Rhythm. 2014 Feb;11(2):202-9. doi: 10.1016/j.hrthm.2013.11.009. Epub 2013 Nov
14.
PY - 2014
SN - 1547-5271
SP - 202-9
ST - Phased RF ablation in persistent atrial fibrillation
T2 - Heart Rhythm
TI - Phased RF ablation in persistent atrial fibrillation
VL - 11
ID - 2459
ER -
TY - JOUR
AB - BACKGROUND AND AIMS: The orientation of the frontal plane T-wave axis (T
axis) is a reliable measure of ventricular repolarisation. We investigated the
association between T-axis and the risk of coronary heart disease (CHD), heart
failure (HF), atrial fibrillation (AF), stroke and cardiovascular (CVD) mortality.
METHODS: A sample of 21,287 Moli-sani participants randomly recruited from the
general adult (≥35 y) Italian population, free of CVD disease, were followed for a
median of 4.4 years. T-axis was measured from a standard 12-lead resting ECG.
RESULTS: After adjusting for CVD risk factors, subjects with abnormal T-axis showed
an increase in the risk of both CHD (Hazard Ratio (HR) = 2.65; 95% CI = 1.67-4.21),
HF (HR = 2.56; 1.80-3.63), AF (HR = 2.48; 1.56-3.94) and CVD mortality (HR = 2.83;
1.50-5.32). The association with CHD and HF, but not with AF or CVD death, remained
significant after further adjustment for ECG abnormalities. Subjects with abnormal
T-axis showed higher levels of subclinical inflammation, hs-troponin I and hs-NT-
proBNP (p < 0.001 for all). However, further adjustment for troponin I and/or NT-
proBNP determined a reduction of HRs ranging from 12.1 to 24.0% for CHD, while
additional adjustment for inflammation markers did not change any association.
CONCLUSIONS: An abnormal T-axis orientation is associated with an increased risk of
both CHD and HF, independently of common CVD risk factors and other ECG
abnormalities. This association was partially explained by increased hs-troponin I
and hs-NT-proBNP levels.
AD - Department of Epidemiology and Prevention, IRCCS Istituto Neurologico
Mediterraneo NEUROMED, Pozzilli, Isernia, Italy; Department of Medicine and
Surgery, University of Insubria, Varese, Italy. Electronic address:
licia.iacoviello@neuromed.it.
Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo
NEUROMED, Pozzilli, Isernia, Italy.
EPICOMED Research, SRL, Campobasso, Italy.
University of Brescia, Brescia, Italy.
AMPS LLC, New York, NY, USA.
Institute of Health and Wellbeing, University of Glasgow, UK.
AN - 28772106
AU - Iacoviello, L.
AU - Bonaccio, M.
AU - Di Castelnuovo, A.
AU - Costanzo, S.
AU - Rago, L.
AU - De Curtis, A.
AU - Assanelli, D.
AU - Badilini, F.
AU - Vaglio, M.
AU - Persichillo, M.
AU - Macfarlane, P. W.
AU - Cerletti, C.
AU - Donati, M. B.
AU - de Gaetano, G.
DA - Sep
DO - 10.1016/j.atherosclerosis.2017.07.021
DP - NLM
ET - 2017/08/05
J2 - Atherosclerosis
KW - *Action Potentials
Adult
Aged
Atrial Fibrillation/blood/*diagnosis/mortality/physiopathology
Biomarkers/blood
Coronary Disease/blood/*diagnosis/mortality/physiopathology
Female
Heart Failure/blood/*diagnosis/mortality/physiopathology
*Heart Rate
Hospitalization
Humans
Inflammation Mediators/blood
Italy
Male
Middle Aged
Prognosis
Prospective Studies
Risk Assessment
Risk Factors
Stroke/blood/*diagnosis/mortality/physiopathology
Troponin I/blood
Cardiovascular disease
Ecg
Heart failure
Population study
T-wave axis
Ventricular repolarisation
LA - eng
N1 - 1879-1484
Iacoviello, Licia
Bonaccio, Marialaura
Di Castelnuovo, Augusto
Costanzo, Simona
Rago, Livia
De Curtis, Amalia
Assanelli, Deodato
Badilini, Fabio
Vaglio, Martino
Persichillo, Mariarosaria
Macfarlane, Peter W
Cerletti, Chiara
Donati, Maria Benedetta
de Gaetano, Giovanni
Moli-sani study Investigators
Journal Article
Multicenter Study
Observational Study
Ireland
Atherosclerosis. 2017 Sep;264:51-57. doi: 10.1016/j.atherosclerosis.2017.07.021.
Epub 2017 Jul 22.
PY - 2017
SN - 0021-9150
SP - 51-57
ST - Frontal plane T-wave axis orientation predicts coronary events: Findings from
the Moli-sani study
T2 - Atherosclerosis
TI - Frontal plane T-wave axis orientation predicts coronary events: Findings from
the Moli-sani study
VL - 264
ID - 2492
ER -
TY - JOUR
AB - OBJECTIVES: To assess prognostic meaning of worsening renal failure (WRF)
occurring during management of chronic heart failure (HF) with reduced ejection
fraction. BACKGROUND: When WRF develops during titration of HF medical therapy, it
commonly leads to less aggressive care. METHODS: A total of 151 patients enrolled
in a prospective, randomized study of standard of care (SOC) HF therapy versus SOC
plus a goal N-terminal pro-B type natriuretic peptide (NT-proBNP) < 1000 pg/mL were
examined. Cardiovascular (CV) event (defined as worsening HF, hospitalization for
HF, significant ventricular arrhythmia, acute coronary or cerebral ischemia, or CV
death) at 1 year relative to WRF (defined as any reduction in estimated glomerular
filtration rate) 90 days postenrollment were tabulated. RESULTS: Those developing
WRF by 3 months had an average 14% reduction in estimated glomerular filtration
rate. There was no difference in incidence of WRF between study arms (43% in SOC,
57% in NT-proBNP, P = .29). During the first 3 months of therapy titration,
incident WRF was associated with numerically fewer CV events at 1 year compared
with those without WRF (mean 0.81 vs 1.16 events, P = .21). WRF was associated
trend toward fewer CV events in the SOC arm (hazard ratio 0.45, 95% confidence
interval 0.16-1.24, P = .12); the NT-proBNP-guided arm had numerically lower CV
event rates regardless of WRF. Subjects with NT-proBNP <1000 pg/mL and WRF received
higher doses of guideline directed medical therapies, lower doses of loop
diuretics, and had significantly lower CV event rates (P < .001). CONCLUSIONS:
Modest degrees of WRF are common during aggressive HF with reduced ejection
fraction management, but we found no significant association with CV outcomes. HF
care guided by NT-proBNP was not associated with more WRF compared with SOC, and
led to benefit regardless of final renal function.
AD - Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts;
Harvard Clinical Research Institute, Boston, Massachusetts.
Massachusetts General Hospital Biostatistics Center, Boston, Massachusetts.
Cardiology Division, Veterans Administration Connecticut Healthcare System, Yale
University School of Medicine, New Haven, Connecticut.
Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts.
Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts; Harvard
Clinical Research Institute, Boston, Massachusetts. Electronic address:
jjanuzzi@partners.org.
AN - 27469482
AU - Ibrahim, N. E.
AU - Gaggin, H. K.
AU - Rabideau, D. J.
AU - Gandhi, P. U.
AU - Mallick, A.
AU - Januzzi, J. L., Jr.
DA - Feb
DO - 10.1016/j.cardfail.2016.07.440
DP - NLM
ET - 2016/07/30
IS - 2
J2 - Journal of cardiac failure
KW - Aged
Biomarkers/analysis
Chronic Disease
Cohort Studies
Disease Progression
Diuretics/therapeutic use
Female
Follow-Up Studies
Glomerular Filtration Rate
Heart Failure/*blood/*drug therapy/mortality
Humans
Kidney Function Tests
Male
Middle Aged
Natriuretic Peptide, Brain/*analysis
Peptide Fragments/*analysis
Prospective Studies
Renal Insufficiency/*physiopathology
Risk Assessment
Survival Analysis
Time Factors
Treatment Outcome
Heart failure
biomarkers
renal failure
LA - eng
N1 - 1532-8414
Ibrahim, Nasrien E
Gaggin, Hanna K
Rabideau, Dustin J
Gandhi, Parul U
Mallick, Aditi
Januzzi, James L Jr
Comparative Study
Journal Article
United States
J Card Fail. 2017 Feb;23(2):121-130. doi: 10.1016/j.cardfail.2016.07.440. Epub 2016
Jul 25.
PY - 2017
SN - 1071-9164
SP - 121-130
ST - Worsening Renal Function during Management for Chronic Heart Failure with
Reduced Ejection Fraction: Results From the Pro-BNP Outpatient Tailored Chronic
Heart Failure Therapy (PROTECT) Study
T2 - J Card Fail
TI - Worsening Renal Function during Management for Chronic Heart Failure with
Reduced Ejection Fraction: Results From the Pro-BNP Outpatient Tailored Chronic
Heart Failure Therapy (PROTECT) Study
VL - 23
ID - 3125
ER -
TY - JOUR
AB - To determine the prevalence of the rhythmic disorders during ischemic stroke,
and to identify the predictive factors of paroxysmal atrial fibrillation (PAF). It
was about a cross-sectional study, descriptive and analytical, conducted to
Brazzaville between january 2012 and december 2016. It related to a consecutive
series of 267 patients victims of a transient ischemic attack (n = 17) or ischemic
stroke (n = 250), documented by cerebral tomodensitometry or brain MRI. All these
patients profited from a recording 24h Holter ECG, carried out within the framework
of etiologic research. The principal recorded rhythmic anomalies were indexed and
the logistic regression allowed the identification of the predictive factors of
PAF. They were 164 men (61.4%) and 103 women (38.6%), old on average of 60.2 ± 12.1
years. The identified cardiovascular risk factors were hypertension (80.1%),
diabetes (13.5%), and tobacco use (6.7%). The 24h Holter ECG, normal in 216 cases
(81%), was pathological in 51 cases (19%). The principal recorded anomalies
consisted into ventricular ectopic beats (n = 32), PAF (n = 7), supraventricular
ectopic beats (n = 5), non-sustained ventricular tachycardia (n = 4), sustained
ventricular tachycardia (n = 2), and type 2 atrio-ventricular block (n = 1). The
frequency of PAF was 2.6%. In bivariate analysis, it was not noted correlation
between PAF and sex (p = 0.55), hypertension (p = 0.42), diabetes (p = 0.64), and
tobacco use (p = 0.61). In multivariate analysis, only the age was the predictive
factor of PAF during ischemic stroke (p = 0.0134). It comes out from this
preliminary study that the emboligenous arrhythmias are relatively rare during
ischemic stroke in Brazzaville. PAF, though little attends, remains primarily
correlated at the age. Its systematic research at the old subjects contributes to
improve the assumption of responsibility.
Publisher: Abstract available from the publisher.
fre
AD - Service de Cardiologie, Centre Hospitalier Universitaire de Brazzaville,
Congo.
Service de Neurologie, Centre Hospitalier Universitaire de Brazzaville, Congo.
AN - 31447992
AU - Ikama, S. M.
AU - Makani, J.
AU - Mpandzou, G.
AU - Ossou-Nguiet, P. M.
AU - Nsitou, B. M.
AU - Lambi, M. N.
AU - Matali, E.
AU - Gombet, T. R.
AU - Kaky, S. G. K.
C2 - PMC6691285
DO - 10.11604/pamj.2018.31.235.17709
DP - NLM
ET - 2019/08/27
J2 - The Pan African medical journal
KW - Adult
Age Factors
Aged
Aged, 80 and over
Arrhythmias, Cardiac/diagnosis/epidemiology/physiopathology
Atrial Fibrillation/complications/*diagnosis
Brain Ischemia/*diagnosis/etiology
Congo/epidemiology
Electrocardiography, Ambulatory/*methods
Female
Humans
Logistic Models
Male
Middle Aged
Prevalence
Risk Factors
Stroke/*diagnosis/etiology
Tomography, X-Ray Computed/methods
Young Adult
Congo
Holter ECG
Ischemic stroke
atrial fibrillation
LA - fre
N1 - 1937-8688
Ikama, Stéphane Méo
Makani, Jospin
Mpandzou, Ghislain
Ossou-Nguiet, Paul Macaire
Nsitou, Bernice Mesmer
Lambi, Munka Nkalla
Matali, Edgard
Gombet, Thierry Raoul
Kaky, Suzy Gisèle Kimbally
Case Reports
Pan Afr Med J. 2018 Dec 19;31:235. doi: 10.11604/pamj.2018.31.235.17709.
eCollection 2018.
OP - Apport du Holter ECG dans le bilan étiologique des infarctus cérébraux à
Brazzaville, Congo.
PY - 2018
SP - 235
ST - [Contribution of Holter ECG in the etiologic diagnosis of the ischemic stroke
in Brazzaville, Congo]
T2 - Pan Afr Med J
TI - [Contribution of Holter ECG in the etiologic diagnosis of the ischemic stroke
in Brazzaville, Congo]
VL - 31
ID - 2322
ER -
TY - JOUR
AB - We describe a 63-year-old man in sinus rhythm (SR) with an ischaemic stroke
involving basal ganglia region on the right side. The patient was known to be
heterozygous for factor V Leiden (FVL) mutation. On diagnostic work-up, no arterial
sources of embolism were found. Transoesophageal echocardiography evidenced a left
atrial (LA) thrombosis without relevant cardiopathies. LA thrombosis is generally
associated to atrial fibrillation, atrial enlargement, mitral valve stenosis and
left ventricular dysfunction, whereas mitral regurgitation is considered
protective. To our knowledge, this is the first report of cardioembolic stroke
related to a LA thrombosis in a patient in SR without risk factors for thrombus
formation except for FVL heterozygosity.
AD - Neurology Unit, Human Prion Diseases Center D.O.M.P., Maria Vittoria
Hospital, Via Cibrario 72, I-10144 Torino, Italy. imperiale@asl3.to.it
AN - 17464477
AU - Imperiale, D.
AU - Cassano, D.
AU - Pomari, F.
AU - Cecchi, E.
AU - Cerrato, P.
AU - Buffa, C.
DA - Apr
DO - 10.1007/s10072-007-0798-9
DP - NLM
ET - 2007/04/28
IS - 2
J2 - Neurological sciences : official journal of the Italian Neurological Society
and of the Italian Society of Clinical Neurophysiology
KW - Arrhythmia, Sinus/*genetics/physiopathology
Atrial Function, Left/*genetics
Basal Ganglia/blood supply/pathology
Brain Ischemia/*genetics/physiopathology
Echocardiography
Factor V/*genetics
Genetic Markers
Genetic Predisposition to Disease/genetics
Heterozygote
Humans
Male
Middle Aged
Mutation/genetics
Stroke/*genetics/physiopathology
Thrombosis/diagnostic imaging/*genetics/physiopathology
LA - eng
N1 - Imperiale, D
Cassano, D
Pomari, F
Cecchi, E
Cerrato, P
Buffa, C
Case Reports
Journal Article
Italy
Neurol Sci. 2007 Apr;28(2):111-3. doi: 10.1007/s10072-007-0798-9.
PY - 2007
SN - 1590-1874 (Print)
1590-1874
SP - 111-3
ST - Ischaemic stroke, factor V Leiden heterozygosity and left atrial thrombosis
in sinus rhythm: a case report
T2 - Neurol Sci
TI - Ischaemic stroke, factor V Leiden heterozygosity and left atrial thrombosis
in sinus rhythm: a case report
VL - 28
ID - 2763
ER -
TY - JOUR
AB - We studied the risk factors associated with cerebral vasospasm following
aneurysmal subarachnoid hemorrhage (SAH). The subjects were 370 patients with
ruptured aneurysms who fulfilled all of the following criteria: admission by day 2
after onset, operation performed by day 3 by the same surgeon (T.I.), Hunt-Hess
grade I-IV, availability of bilateral carotid angiograms acquired by day 2 and
repeated between days 7 and 9. The demographic, clinical, radiographic, surgical,
laboratory, and electrocardiographic data were analyzed for angiographic vasospasm
(AV), symptomatic vasospasm (SV), and cerebral infarction on computed tomography
(CT) scan. Both CT-evident SAH and AV were graded as 0-IV. Among the 370 patients,
AV grade III-IV, SV, and cerebral infarction occurred in 26%, 24%, and 20%,
respectively. Univariate analysis showed that Hunt-Hess grade III-IV, SAH grade
III-IV, intracerebral or/and intraventricular hemorrhage, rebleeding, cigarette
smoking, hypertension, alcohol intake, leukocytosis, hyperglycemia, and
electrocardiographic QTc prolongation, left ventricular hypertrophy (LVH), and ST
depression were significantly related to at least one of AV grade III-IV, SV, or
cerebral infarction. Multivariate analysis showed that SAH grade III-IV was the
most important risk factor for vasospasm followed by LVH on electrocardiogram,
cigarette smoking, and hypertension. AV grade III-IV, SV, and cerebral infarction
occurred in 57%, 54%, and 39% of the 46 smokers with LVH, and in 43%, 49%, and 35%
of the 68 patients who had both LVH and hypertension, respectively. CT-evident SAH,
LVH, cigarette smoking, and hypertension are associated with vasospasm. In smokers
or hypertensive patients, premorbid LVH appears to predict much more severe
vasospasm.
AD - Department of Neurosurgery, Shimane Prefectural Central Hospital.
AN - 24670311
AU - Inagawa, T.
AU - Yahara, K.
AU - Ohbayashi, N.
C2 - PMC4533446 institutional interest in any of the drugs, materials, or devices
in the article. All authors who are members of The Japan Neurosurgical Society
(JNS) have registered online Self-reported COI Disclosure Statement Forms through
the website for JNS members.
DA - Jun 17
DO - 10.2176/nmc.oa.2013-0169
DP - NLM
ET - 2014/03/29
IS - 6
J2 - Neurologia medico-chirurgica
KW - Alcohol Drinking/epidemiology
Cerebral Angiography
Cerebral Infarction/diagnostic imaging/epidemiology/etiology
Comorbidity
Electrocardiography
Humans
Hyperglycemia/epidemiology
Intracranial Aneurysm/complications/diagnostic imaging/surgery
Leukocytosis/epidemiology
Long QT Syndrome/epidemiology
Recurrence
Risk Factors
Rupture, Spontaneous
Subarachnoid Hemorrhage/*complications/diagnostic imaging
Vasospasm, Intracranial/diagnostic imaging/*epidemiology/etiology
LA - eng
N1 - 1349-8029
Inagawa, Tetsuji
Yahara, Kaita
Ohbayashi, Naohiko
Journal Article
Neurol Med Chir (Tokyo). 2014 Jun 17;54(6):465-73. doi: 10.2176/nmc.oa.2013-0169.
Epub 2014 Mar 27.
PY - 2014
SN - 0470-8105 (Print)
0470-8105
SP - 465-73
ST - Risk factors associated with cerebral vasospasm following aneurysmal
T2 - Neurol Med Chir (Tokyo)
TI - Risk factors associated with cerebral vasospasm following aneurysmal
VL - 54
ID - 2826
ER -
TY - JOUR
AB - Atrial fibrillation is a frequently encountered arrhythmia, particularly
affecting the elderly. Patients at significant risk for stroke should be considered
for anticoagulation with warfarin. Management of atrial fibrillation revolves
around either controlling the ventricular rate response or trying to maintain sinus
rhythm with either pharmacologic or nonpharmacologic therapies. There are many
treatment options to consider, based upon the patient's expectations, symptoms, and
comorbid conditions. Therefore, the treatment of atrial fibrillation must be
individualized.
AD - Sarver Heart Center, College of Medicine, University of Arizona, Tucson
85724, USA. jindik@email.arizona.edu
AN - 19375546
AU - Indik, J. H.
AU - Alpert, J. S.
DA - May
DO - 10.1016/j.amjmed.2008.12.012
DP - NLM
ET - 2009/04/21
IS - 5
*Atrial Fibrillation/complications/epidemiology/therapy
Europe/epidemiology
Humans
Incidence
Risk Factors
Sex Distribution
LA - eng
N1 - 1555-7162
Indik, Julia Heisler
Alpert, Joseph S
Journal Article
Review
United States
Am J Med. 2009 May;122(5):415-8. doi: 10.1016/j.amjmed.2008.12.012.
PY - 2009
SN - 0002-9343
SP - 415-8
ST - The patient with atrial fibrillation
T2 - Am J Med
TI - The patient with atrial fibrillation
VL - 122
ID - 2561
ER -
TY - JOUR
AB - OBJECTIVES: The adverse effects of left atrial appendage (LAA) closure have
not yet been evaluated. This study aimed to prove the safety and low invasiveness
of LAA resection through our thoracoscopic stand-alone left atrial appendectomy
experience. METHODS: Eighty-seven patients [mean age 68 ± 9 years, 68 men (78%),
mean congestive heart failure, hypertension, age ≥ 75 years, diabetes mellitus,
prior stroke or transient ischaemic attack to thromboembolism, vascular disease,
age 65-74 years and sex category (CHA2DS2-VASc) score 2.9 ± 1.6 points] who had
undergone thoracoscopic left atrial appendectomy were selected. The operative and
clinical data (left atrial diameter, left ventricular diameter of systole/diastole,
ejection fraction, brain natriuretic peptide and human atrial natriuretic peptide)
were evaluated. All procedures were performed without cardiopulmonary bypass or
cardiac arrest. The LAA was resected with an endoscopic linear cutter device.
Except for 1 case with severe pleural adhesion, all operations were performed
thoracoscopically. RESULTS: The preoperative and postoperative data are as follows:
left atrial diameter 43 ± 5 mm and 43 ± 5 mm (P = 0.8); left ventricular diameter
of systole/diastole 50 ± 5/35 ± 6 mm and 48 ± 5/34 ± 6 mm (P < 0.01); ejection
fraction 57 ± 10% and 56 ± 10% (P = 0.11); brain natriuretic peptide 97 ± 77 pg/ml
and 72 ± 65 pg/ml (P < 0.01) and human atrial natriuretic peptide 73 ± 64 pg/ml and
96 ± 67 pg/ml (P = 0.03), respectively. The mean volume of bleeding in the
operation was very small (<10 ml). The mean length of postoperative in-hospital
stay was 3.8 ± 1.8 days. All the patients were discharged while maintaining their
preoperative activities of daily living without major complications. No thrombus or
residual stumps were detected during the 3-month postoperative computed tomography
follow-up. The perioperative heart function did not change significantly in this
study. Bleeding with resection was minimal, and no rebleeding events occurred.
CONCLUSIONS: LAA resection did not affect negatively on the cardiac function and
did not increase the risk of bleeding risk.
AD - Department of Cardiac Surgery, University of Tokyo, Tokyo, Japan.
Department of Cardiovascular Surgery, Tsukuba Memorial Hospital, Tsukuba, Japan.
AN - 29370349
AU - Inoue, T.
AU - Suematsu, Y.
DA - Jul 1
DO - 10.1093/ejcts/ezx506
DP - NLM
ET - 2018/01/26
IS - 1
KW - Aged
Atrial Appendage/diagnostic imaging/*surgery
Atrial Fibrillation/complications/diagnostic imaging/*surgery
Blood Loss, Surgical
Female
Humans
Male
Middle Aged
Thoracoscopy/adverse effects/*methods
LA - eng
N1 - 1873-734x
Inoue, Takafumi
Suematsu, Yoshihiro
Evaluation Study
Journal Article
Germany
Eur J Cardiothorac Surg. 2018 Jul 1;54(1):78-83. doi: 10.1093/ejcts/ezx506.
PY - 2018
SN - 1010-7940
SP - 78-83
ST - Left atrial appendage resection can be performed minimally invasively with
good clinical and echocardiographic outcomes without any severe risk
TI - Left atrial appendage resection can be performed minimally invasively with
good clinical and echocardiographic outcomes without any severe risk
VL - 54
ID - 2510
ER -
TY - JOUR
AB - BACKGROUND: Recent evidence suggests that left atrial (LA) dysfunction may be
mechanistically contributing to cerebrovascular events in patients with atrial
fibrillation (AF). We investigated the association between regional LA function and
a prior history of stroke during sinus rhythm in patients referred for catheter
ablation of AF. METHODS AND RESULTS: A total of 169 patients (59 ± 10 years, 74%
male, 29% persistent AF) with a history of AF in sinus rhythm at the time of pre-
ablation cardiac magnetic resonance (CMR) were analyzed. The LA volume, emptying
fraction, strain (S), and strain rate (SR) were assessed by tissue-tracking cardiac
magnetic resonance. The patients with a history of stroke or transient ischemic
attack (n=18) had greater LA volumes (Vmax and Vmin; P=0.02 and P<0.001,
respectively), lower LA total emptying fraction (P<0.001), lower LA maximum and
pre-atrial contraction strains (Smax and SpreA; P<0.001 and P=0.01, respectively),
and lower absolute values of LA SR during left ventricular (LV) systole and early
diastole (SRs and SRe; P=0.005 and 0.03, respectively) than those without
stroke/transient ischemic attack (n=151). Multivariable analysis demonstrated that
the LA reservoir function, including total emptying fraction, Smax, and SRs, was
associated with stroke/transient ischemic attack (odds ratio 0.94, 0.91, and 0.17;
P=0.03, 0.02, and 0.04, respectively) after adjusting for the CHA2DS2-VASc score
and LA Vmin. CONCLUSIONS: Depressed LA reservoir function assessed by tissue-
tracking cardiac magnetic resonance is significantly associated with a prior
history of stroke/transient ischemic attack in patients with AF. Our findings
suggest that assessment of LA reservoir function can improve the risk
stratification of cerebrovascular events in AF patients.
AD - Division of Cardiology, Johns Hopkins University School of Medicine,
Baltimore, MD (Y.Y.I., A.A., I.M.K., K.F., M.H., S.N., R.D.B., H.C., J.A.L., H.A.).
The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns
Hopkins University School of Medicine, Baltimore, MD (B.A.V., S.L.Z.).
Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD
(Y.Y.I., A.A., I.M.K., K.F., M.H., S.N., R.D.B., H.C., J.A.L., H.A.) Department of
Epidemiology, Johns Hopkins University School of Public Health, Baltimore, MD
(S.N.).
Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD
(Y.Y.I., A.A., I.M.K., K.F., M.H., S.N., R.D.B., H.C., J.A.L., H.A.) Department of
Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD
(R.D.B., H.A.).
AN - 25917441
AU - Inoue, Y. Y.
AU - Alissa, A.
AU - Khurram, I. M.
AU - Fukumoto, K.
AU - Habibi, M.
AU - Venkatesh, B. A.
AU - Zimmerman, S. L.
AU - Nazarian, S.
AU - Berger, R. D.
AU - Calkins, H.
AU - Lima, J. A.
AU - Ashikaga, H.
C2 - PMC4579945
DA - Apr 27
DO - 10.1161/jaha.115.001844
DP - NLM
ET - 2015/04/29
IS - 4
KW - Aged
Female
Humans
Male
Middle Aged
Risk Factors
atrial fibrillation
atrial strain
stroke
tracking
LA - eng
N1 - 2047-9980
Inoue, Yuko Y
Alissa, Abdullah
Khurram, Irfan M
Fukumoto, Kotaro
Habibi, Mohammadali
Venkatesh, Bharath A
Zimmerman, Stefan L
Nazarian, Saman
Berger, Ronald D
Calkins, Hugh
Lima, Joao A
Ashikaga, Hiroshi
Journal Article
J Am Heart Assoc. 2015 Apr 27;4(4):e001844. doi: 10.1161/JAHA.115.001844.
PY - 2015
SN - 2047-9980
ST - Quantitative tissue-tracking cardiac magnetic resonance (CMR) of left atrial
deformation and the risk of stroke in patients with atrial fibrillation
TI - Quantitative tissue-tracking cardiac magnetic resonance (CMR) of left atrial
deformation and the risk of stroke in patients with atrial fibrillation
VL - 4
ID - 2511
ER -
TY - JOUR
AB - The P-wave terminal force in lead V(1) (PTFV(1)) on the 12-lead
electrocardiogram (ECG) quantifies left atrial (LA) structural and
electrophysiologic abnormalities. We aimed to evaluate the association between
PTFV(1) and cerebrovascular accident (CVA) as well as LA structure and function in
patients with atrial fibrillation (AF). We conducted a cross-sectional study of 229
patients with AF (60 ± 10years, 72% men) with (n = 21) and without (n = 208) a
history of CVA, who underwent preablation ECG and cardiac magnetic resonance in
sinus rhythm. PTFV(1) was defined as the duration (in milliseconds) of the downward
deflection of the P wave in lead V(1) multiplied by the absolute value of its
amplitude (in microvolts) on ECG. PTFV(1) is associated with LA minimum volume
(V(min)) and left ventricular ejection fraction but not associated with the extent
of LA fibrosis quantified by cardiac magnetic resonance late gadolinium
enhancement. In addition, PTFV(1) is associated with CVA independent of the
CHA(2)DS(2)-VASc score and LA V(min) (odds ratio 1.23; 95% confidence interval 1.08
to 1.40; p = 0.002). Furthermore, PTFV(1) has an incremental value over the
CHA(2)DS(2)-VASc score as a marker of CVA (p <0.001). In conclusion, ECG-defined
PTFV(1) is independent marker of stroke in patients with AF and reflects the
underlying LA remodeling. Our findings suggest that evaluation of PTFV(1) can
improve the current risk stratification of stroke.
Baltimore, Maryland; Department of Cardiovascular Medicine, National Cerebral and
Cardiovascular Center, Suita, Osaka, Japan.
Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore,
Maryland.
Maryland; Division of Cardiology, New York Presbyterian/Columbia University Medical
Center, New York, New York.
The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns
Hopkins University School of Medicine, Baltimore, Maryland.
Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio.
Section for Cardiac Electrophysiology, Perelman School of Medicine at the
University of Pennsylvania, Philadelphia, Pennsylvania.
Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center,
Suita, Osaka, Japan.
Maryland; The Russell H. Morgan Department of Radiology and Radiological Sciences,
Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of
Epidemiology, Johns Hopkins University School of Public Health, Baltimore,
Maryland.
Maryland; Department of Biomedical Engineering, Johns Hopkins University School of
Medicine, Baltimore, Maryland.
Maryland. Electronic address: hashika1@jhmi.edu.
AN - 29933926
AU - Inoue, Y. Y.
AU - Ipek, E. G.
AU - Khurram, I. M.
AU - Ciuffo, L.
AU - Chrispin, J.
AU - Zimmerman, S. L.
AU - Marine, J. E.
AU - Rickard, J.
AU - Spragg, D. D.
AU - Nazarian, S.
AU - Kusano, K.
AU - Lima, J. A.
AU - Berger, R. D.
AU - Calkins, H.
AU - Ashikaga, H.
DA - Jul 15
DO - 10.1016/j.amjcard.2018.03.369
DP - NLM
ET - 2018/06/24
IS - 2
KW - Atrial Fibrillation/*complications/diagnosis/physiopathology
Atrial Remodeling/*physiology
Female
Follow-Up Studies
Heart Atria/diagnostic imaging/*physiopathology
Humans
Incidence
Magnetic Resonance Imaging, Cine
Male
Middle Aged
Prospective Studies
*Risk Assessment
Risk Factors
LA - eng
N1 - 1879-1913
Inoue, Yuko Y
Ipek, Esra G
Khurram, Irfan M
Ciuffo, Luisa
Chrispin, Jonathan
Zimmerman, Stefan L
Marine, Joseph E
Rickard, John
Spragg, David D
Nazarian, Saman
Kusano, Kengo
Lima, Joao A
Berger, Ronald D
Calkins, Hugh
Ashikaga, Hiroshi
Journal Article
United States
2018 May 3.
PY - 2018
SN - 0002-9149
SP - 242-247
ST - Relation of Electrocardiographic Left Atrial Abnormalities to Risk of Stroke
in Patients with Atrial Fibrillation
T2 - Am J Cardiol
TI - Relation of Electrocardiographic Left Atrial Abnormalities to Risk of Stroke
in Patients with Atrial Fibrillation
VL - 122
ID - 2468
ER -
TY - JOUR
AB - BACKGROUND: Though systemic thromboembolism is not an infrequent complication
of rheumatic valvular disease, multiple embolic phenomena are rare. OBJECTIVE: To
present a patient with rheumatic heart disease associated with multiple embolic
complications. CASE REPORT: A 44-year-old lady with rheumatic valvular disease and
atrial fibrillation defaulted anticoagulant medication, and subsequently presented
with acute chest pain, acute left ventricular failure, focal neurological deficit
and gangrenous lower limb extremities. Electrocardiography showed atrial
fibrillation and an old anteroseptal myocardial infarction. Echocardiography showed
multiple valvular lesions and multiple thrombi in the left atrium. Computed
tomogram scan demonstrated a large infarct involving the region supplied by the
right middle cerebral artery. Bilateral above knee amputation was performed.
Recovery from neurological deficit was complete. She had, during a 4-year follow-up
and anticoagulation remained free of new clinically evident embolic complications.
Serial echocardiography however showed that the atrial clots had persisted and
presumably fibrosed. CONCLUSION: Multiple systemic thromboembolisms are serious
complication of atrial fibrillation of valvular aetiology, and their prevention
requires continuous anticoagulation.
AD - Department of Medicine Usmanu Danfodiyo University Teaching Hospital, Sokoto,
Nigeria. simeonisezuo@yahoo.com
AN - 20425747
AU - Isezuo, S. A.
AU - Musa, A. A.
AU - Saidu, S. A.
DA - Jul-Aug
DP - NLM
ET - 2010/04/29
IS - 4
J2 - West African journal of medicine
KW - Adult
Atrial Fibrillation/*complications/diagnostic imaging/drug therapy
Embolism/diagnostic imaging/*etiology
Female
Heparin/therapeutic use
Humans
Rheumatic Heart Disease/*complications/diagnostic imaging
Ultrasonography
LA - eng
N1 - Isezuo, S A
Musa, A A
Saidu, S A
Case Reports
Journal Article
Nigeria
West Afr J Med. 2009 Jul-Aug;28(4):274-6.
PY - 2009
SN - 0189-160X (Print)
0189-160x
SP - 274-6
ST - Multiple embolisations in rheumatic heart disease: a case report
T2 - West Afr J Med
TI - Multiple embolisations in rheumatic heart disease: a case report
VL - 28
ID - 2915
ER -
TY - JOUR
AB - BACKGROUND: Pathophysiology of extracorporeal circulation is multifactorial,
and the link between newly developed "biomaterials" and clinical outcome is not
easy to illustrate. MATERIAL AND METHODS: We designed a randomized, double-blinded,
prospective study in order to verify the impact of a new surface modification
[SMAR(X)T] in combination with an optimized blood air interface, on the cerebral
performance after cardiopulmonary bypass. 80 patients were randomly divided into
two subgroups (SMAR(X)T vs. standard PVC control) and analyzed for the kinetic of
cerebral ischemia markers neuronspecific enolase, protein S100 and
neuropsychologically tested with the Mini-Mental-Status Test (MMST) before and
after the operation. RESULTS: We could not show significant differences of protein
S100 and neuron-specific enolase (NSE) levels between SMAR(X)T patients and the
controls, but the incidence of neurological complications was exceptionally low.
Although no statistically significant differences could be obtained for the MMST,
the different pointloss between both groups trends toward a better cerebral
performance in SMAR(X)T patients. CONCLUSION: The use of a biologically inert
circuit in combination with an optimized perfusion management seems to be worthy of
recommendation.
AD - Klinik für Herzchirurgie, Herzzentrum Ludwigshafen, Germany. isgrof@klilu.de
AN - 11339453
AU - Isgro, F.
AU - Kiessling, A. H.
AU - Mittelstaedt, H.
AU - Saggau, W.
DA - Apr
DO - 10.1055/s-2001-11699
DP - NLM
ET - 2001/05/08
IS - 2
J2 - The Thoracic and cardiovascular surgeon
KW - Adaptation, Physiological
Adaptation, Psychological
*Biocompatible Materials
Biomarkers/analysis
Brain Ischemia/*diagnosis/etiology
Cardiopulmonary Bypass/*adverse effects/*instrumentation/methods
Coronary Disease/surgery
Double-Blind Method
Extracorporeal Circulation/*instrumentation
Female
Follow-Up Studies
Humans
Male
Mental Competency
Middle Aged
Neurologic Examination
Phosphopyruvate Hydratase/*analysis
Probability
Prospective Studies
Protein S/*analysis
Reference Values
Risk Assessment
Surface Properties
LA - eng
N1 - Isgro, F
Kiessling, A H
Mittelstaedt, H
Saggau, W
Clinical Trial
Comparative Study
Journal Article
Germany
Thorac Cardiovasc Surg. 2001 Apr;49(2):65-9. doi: 10.1055/s-2001-11699.
PY - 2001
SN - 0171-6425 (Print)
0171-6425
SP - 65-9
ST - Surface modification of extracorporeal circuits: is there really an impact on
cerebral performance after cardiopulmonary bypass?
T2 - Thorac Cardiovasc Surg
TI - Surface modification of extracorporeal circuits: is there really an impact on
cerebral performance after cardiopulmonary bypass?
VL - 49
ID - 3087
ER -
TY - JOUR
AB - AIMS: Left ventricular (LV) diastolic function assessed by tissue Doppler
imaging (TDI) is reported to be associated with left atrial (LA) blood stasis in
patients with non-valvular atrial fibrillation (AF). This study aimed to evaluate
the relationship of diastolic TDI parameters with silent brain infarction (SBI) on
brain magnetic resonance imaging (MRI), and in turn the risks of subsequent stroke
or dementia, in non-valvular AF patients. METHODS AND RESULTS: The study population
consisted of 171 neurologically asymptomatic patients with non-valvular AF who
underwent transoesophageal echocardiography (TOE) (128 men; mean age, 63 ± 11
years). We measured diastolic TDI parameters by transthoracic echocardiography, and
also screened for SBI employing brain MRI. Early transmitral flow velocity (E) and
mitral annular velocity by TDI (e') were measured, and E/e' ratios were calculated.
An increased tertile of the E/e' ratio was significantly related to high
prevalences of LA abnormalities detected by TOE (32% vs. 12% vs. 9%; P =0.002) and
SBI on brain MRI (46% vs. 23% vs. 14%; P < 0.001). In multivariate logistic
regression analyses after adjustment for age, hypertension, chronic kidney disease,
and CHA2DS2-VASc score ≥2, the E/e' ratio ≥12.4 was found to be an independent
predictor of the presence of SBI (OR 3.98, 95% CI 1.74-9.07; P = 0.001).
CONCLUSIONS: Impaired LV diastolic function evaluated by increased E/e' ratio was
closely associated with the presence of SBI independent of CHA2DS2-VASc score. TDI
measurements are non-invasive and useful for risk stratification of the early stage
of cerebral damages in patients with non-valvular AF.
AD - Department of Cardiovascular Medicine, Osaka City University Graduate School
of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan.
Department of Radiology, Osaka City University Graduate School of Medicine, Osaka,
Japan.
Morinomiya University of Medical Science, Osaka, Japan.
AN - 28039210
AU - Ishikawa, S.
AU - Sugioka, K.
AU - Sakamoto, S.
AU - Fujita, S.
AU - Ito, A.
AU - Norioka, N.
AU - Iwata, S.
AU - Nakagawa, M.
AU - Takagi, M.
AU - Miki, Y.
AU - Ueda, M.
AU - Yoshiyama, M.
DA - Nov 1
DO - 10.1093/ehjci/jew220
DP - NLM
ET - 2017/01/01
IS - 11
J2 - European heart journal cardiovascular Imaging
KW - Atrial Fibrillation/*diagnostic imaging/*physiopathology
Brain Infarction/*diagnostic imaging/*physiopathology
Diastole
Echocardiography, Doppler/*methods
Female
Humans
Male
Middle Aged
Prospective Studies
Risk Factors
Ventricular Dysfunction, Left/*diagnostic imaging/*physiopathology
atrial fibrillation
echocardiography
silent brain infarction
tissue Doppler imaging
LA - eng
N1 - 2047-2412
Ishikawa, Sera
Sugioka, Kenichi
Sakamoto, Shinichi
Fujita, Suwako
Ito, Asahiro
Norioka, Naoki
Iwata, Shinichi
Nakagawa, Masashi
Takagi, Masahiko
Miki, Yukio
Ueda, Makiko
Yoshiyama, Minoru
Journal Article
England
Eur Heart J Cardiovasc Imaging. 2017 Nov 1;18(11):1245-1252. doi:
10.1093/ehjci/jew220.
PY - 2017
SN - 2047-2404
SP - 1245-1252
ST - Relationship between tissue Doppler measurements of left ventricular
diastolic function and silent brain infarction in patients with non-valvular atrial
fibrillation
T2 - Eur Heart J Cardiovasc Imaging
TI - Relationship between tissue Doppler measurements of left ventricular
diastolic function and silent brain infarction in patients with non-valvular atrial
fibrillation
VL - 18
ID - 2333
ER -
TY - JOUR
AB - We conducted a prospective study investigating the relationship between blood
pressure values and the risk of cardiovascular disease in patients with end-stage
renal diseases. Five hundred fifty-three patients on chronic hemodialysis were
followed for 5 years, and the relationship between systolic blood pressure (SBP),
diastolic blood pressure (DBP), mean blood pressure (MBP) and pulse pressure (PP)
and the incidence of death and cardiovascular events were evaluated. There were 85
cardiovascular and 88 non-cardiovascular deaths during the 5 years. Fatal and
nonfatal cardiovascular events occurred in 205 patients. Factors such as old age,
diabetes and electrocardiographic findings of left ventricular hypertrophy and
arrhythmia were associated with a high incidence of cardiovascular events as well
as the incidence of death. With regard to blood pressure values, only PP was
significantly associated with the risk of death (p=0.003). Both SBP and PP showed a
significant association with the incidence of cardiovascular events (p=0.004 and
p<0.001). In other words, an increase in PP by 10 mmHg corresponded to a 22%
increase in cardiovascular events, and a 10 mmHg SBP increase corresponded to a 10%
increase in cardiovascular events. In conclusion, PP is a better predictor of death
and cardiovascular events than other blood pressure values in chronic hemodialysis
patients.
AD - Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical
University, Mibu, Tochigi, Japan. isimitu@dokkyomed.ac.jp
AN - 18971548
AU - Ishimitsu, T.
AU - Nakano, N.
AU - Sudo, Y.
AU - Akashiba, A.
AU - Takahashi, T.
AU - Ohta, S.
AU - Minami, J.
AU - Matsuoka, H.
DA - Sep
DO - 10.1291/hypres.31.1703
DP - NLM
ET - 2008/10/31
IS - 9
J2 - Hypertension research : official journal of the Japanese Society of
Hypertension
KW - Aged
*Blood Pressure
Female
Heart Diseases/*mortality
Humans
Hypertension/*mortality
Incidence
Kidney Failure, Chronic/*mortality/therapy
Male
Middle Aged
Prognosis
Renal Dialysis/*mortality/statistics & numerical data
Risk Factors
Stroke/*mortality
LA - eng
N1 - Ishimitsu, Toshihiko
Nakano, Nobuyuki
Sudo, Yasuyo
Akashiba, Akira
Takahashi, Toshiaki
Ohta, Satoshi
Minami, Junichi
Matsuoka, Hiroaki
Journal Article
England
Hypertens Res. 2008 Sep;31(9):1703-9. doi: 10.1291/hypres.31.1703.
PY - 2008
SN - 0916-9636 (Print)
0916-9636
SP - 1703-9
ST - Predictive significance of blood pressure values for the incidence of
cardiovascular events in chronic hemodialysis patients
T2 - Hypertens Res
TI - Predictive significance of blood pressure values for the incidence of
cardiovascular events in chronic hemodialysis patients
VL - 31
ID - 2954
ER -
TY - JOUR
AB - The natural courses of 82 patients with hypertrophic cardiomyopathy (HCM)
were investigated in follow-up periods of over 10 years (mean follow-up: 11.7
yrs.). Twelve patients had obstructive, 30 non-obstructive and 40 apical HCM. There
were 76 males and 6 females. The mean age at the initial diagnosis was 48 years.
All patients underwent cardiac catheterization and left ventriculography, and two-
dimensional echocardiography was conducted in some patients. To determine the
clinical features influencing the prognosis, their serial laboratory and clinical
data were reviewed and analyzed. Five patients died of non-cardiac causes. Only one
died suddenly. Congestive heart failure developed in 3 patients, 2 with obstructive
and one with non-obstructive HCM. Two patients had cavity dilatation and
deteriorated ventricular function, and finally exhibited dilated cardiomyopathy-
like features. Characteristically, in this deteriorating group, a decrease in the
QRS voltage and an abnormal Q wave gradually developed without clinical evidence of
myocardial infarction. Two patients with apical HCM in this group had decreases in
their QRS voltages and in the depths of their giant negative T waves. They
developed apical left ventricular asynergy without myocardial infarction or
congestive heart failure. There were no specific clinical or laboratory parameters
predictive of sudden death. Atrial fibrillation occurred in 9 patients, resulting
in 3 cases of cerebral infarction, one myocardial infarction, and one congestive
heart failure. One patient received pacemaker implantation because of the sick
sinus syndrome. Three had acute myocardial infarction. Aortocoronary bypass
grafting was performed in 3 patients. These results indicate that the good long-
term life prognosis of HCM can be expected in all types of HCM. Among the 82
patients, only one died suddenly. However, since the natural history of HCM can
take a variety of courses, careful observation is necessary.
AD - Division of Cardiology, Toranomon Hospital, Tokyo.
AN - 1817182
AU - Ishiwata, S.
AU - Nishiyama, S.
AU - Nakanishi, S.
AU - Nishimura, S.
AU - Yanagishita, Y.
AU - Kato, K.
AU - Seki, A.
AU - Yamaguchi, H.
DP - NLM
ET - 1991/01/01
IS - 1
Cardiomyopathy, Hypertrophic/classification/complications/*physiopathology
Cerebral Infarction/complications
Electrocardiography
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prognosis
Time Factors
LA - jpn
N1 - Ishiwata, S
Nishiyama, S
Nakanishi, S
Nishimura, S
Yanagishita, Y
Kato, K
Seki, A
Yamaguchi, H
Case Reports
English Abstract
Journal Article
Netherlands
J Cardiol. 1991;21(1):61-73.
PY - 1991
SN - 0914-5087 (Print)
0914-5087
SP - 61-73
ST - [Natural history of 82 patients with hypertrophic cardiomyopathy: follow-up
for over ten years]
T2 - J Cardiol
TI - [Natural history of 82 patients with hypertrophic cardiomyopathy: follow-up
for over ten years]
VL - 21
ID - 2784
ER -
TY - JOUR
AB - Atrial fibrillation is the most common arrhythmia in clinical practice, may
coexist with conditions common to both cardiovascular and noncardiovascular
diseases and is associated with considerable morbidity and mortality. Atrial
fibrillation is often asymptomatic and diagnosed only when it has caused a
potentially serious complication, such as an ischemic stroke. When atrial
fibrillation has been identified, 2 objectives have to be addressed--the
antiarrhythmic therapy based on rate control or rhythm control, and prevention of
thromboembolism. A rhythm or rate control strategy can be chosen indifferently
because they have comparable efficacy for the outcome measure of mortality, but the
antithrombotic therapy is ever mandatory. The risk of stroke increases cumulatively
with increasing age, previous transient ischemic attack or stroke, hypertension,
diabetes mellitus, impaired left ventricular function and heart failure. Warfarin
reduces the risk of stroke by about two thirds; and aspirin, by about one fifth,
but its use must be weighted with the risk of bleeding. The risk of anticoagulant-
associated hemorrhage increases with age, the presence of serious concomitant
diseases, with poorly controlled hypertension and poorly controlled
anticoagulation.
AD - Department of Internal Medicine, Unit of Vascular Medicine, Sapienza
University of Rome, Rome, Italy. luigi.iuliano@uniroma1.it
AN - 19805924
AU - Iuliano, L.
AU - Di Matteo, A.
AU - Straface, G.
DA - Sep
DO - 10.4103/0019-5359.56111
DP - NLM
ET - 2009/10/07
IS - 9
J2 - Indian journal of medical sciences
KW - Anti-Arrhythmia Agents/adverse effects/*therapeutic use
Atrial Fibrillation/complications/diagnosis/*drug therapy/pathology
Fibrinolytic Agents/adverse effects/*therapeutic use
Humans
Risk Factors
LA - eng
N1 - 1998-3654
Iuliano, Luigi
Di Matteo, Antonio
Straface, Giuseppe
Journal Article
Review
India
Indian J Med Sci. 2009 Sep;63(9):419-30. doi: 10.4103/0019-5359.56111.
PY - 2009
SN - 0019-5359
SP - 419-30
ST - Management of nonvalvular atrial fibrillation: a comprehensive approach
T2 - Indian J Med Sci
TI - Management of nonvalvular atrial fibrillation: a comprehensive approach
VL - 63
ID - 2469
ER -
TY - JOUR
AB - BACKGROUND: Presence of prominent left ventricular trabeculation satisfying
criteria for left ventricular noncompaction (LVNC) on routine cardiac magnetic
resonance examination is frequently encountered; however, the clinical and
prognostic significance of these findings remain elusive. This registry aimed to
assess LVNC prevalence by 4 current criteria and to prospectively evaluate an
association between diagnosis of LVNC by these criteria and adverse events. METHODS
AND RESULTS: There were 700 patients referred for cardiac magnetic resonance: 42%
were women, median age was 70 years (range, 45-71 years), mean left ventricular
ejection fraction was 51% (±17%), and 32% had late gadolinium enhancement on
cardiac magnetic resonance. The cohort underwent diagnostic assessment for LVNC by
4 separate imaging criteria-referenced by their authors as Petersen, Stacey,
Jacquier, and Captur, with LVNC prevalence of 39%, 23%, 25% and 3%, respectively.
Primary clinical outcome was combined end point of time to death, ischemic stroke,
ventricular tachycardia/ventricular fibrillation, and heart failure
hospitalization. Secondary clinical outcomes were (1) all-cause mortality and (2)
time to the first occurrence of any of the following events: cardiac death,
ischemic stroke, ventricular tachycardia/ventricular fibrillation, or heart failure
hospitalization. During a median follow-up of 7 years, there were no statistically
significant differences in assessed outcomes noted between patients with and
without LVNC irrespective of the applied criteria. CONCLUSIONS: Current criteria
for the diagnosis of LVNC leads to highly variable disease prevalence in patients
referred for cardiac magnetic resonance. The diagnosis of LVNC, by any current
criteria, was not associated with adverse clinical events on nearly 7 years of
follow-up. Limited conclusions can be made for Captur criteria due to low observed
prevalence.
AD - From the Division of Cardiology, Department of Medicine, NewYork-Presbyterian
Brooklyn Methodist Hospital (A.I., D.S.D., G.P.B., A.M., A.A., J.H., S.A.K., A.G.,
T.J.S., J.F.H.); Department of Statistical Sciences, NewYork-Presbyterian Cornell
University, Ithaca (W.M.B.); and Division of Cardiology, Department of Medicine,
Duke University Medical Center, Durham, NC (I.K.).
From the Division of Cardiology, Department of Medicine, NewYork-Presbyterian
Brooklyn Methodist Hospital (A.I., D.S.D., G.P.B., A.M., A.A., J.H., S.A.K., A.G.,
T.J.S., J.F.H.); Department of Statistical Sciences, NewYork-Presbyterian Cornell
University, Ithaca (W.M.B.); and Division of Cardiology, Department of Medicine,
Duke University Medical Center, Durham, NC (I.K.). jfh9003@nyp.org.
AN - 28899950
AU - Ivanov, A.
AU - Dabiesingh, D. S.
AU - Bhumireddy, G. P.
AU - Mohamed, A.
AU - Asfour, A.
AU - Briggs, W. M.
AU - Ho, J.
AU - Khan, S. A.
AU - Grossman, A.
AU - Klem, I.
AU - Sacchi, T. J.
AU - Heitner, J. F.
DA - Sep
DO - 10.1161/circimaging.117.006174
DP - NLM
ET - 2017/09/14
IS - 9
J2 - Circulation. Cardiovascular imaging
KW - Aged
Contrast Media/administration & dosage
Female
Hospitalization
Humans
Isolated Noncompaction of the Ventricular Myocardium/*diagnostic
imaging/*epidemiology/mortality/physiopathology
*Magnetic Resonance Imaging, Cine
Male
Middle Aged
New York City/epidemiology
Observer Variation
Prevalence
Prospective Studies
*Referral and Consultation
Registries
Risk Factors
Stroke/epidemiology
Stroke Volume
Time Factors
heart failure
magnetic resonance imaging
mortality
prognosis
stroke
LA - eng
N1 - 1942-0080
Ivanov, Alexander
Dabiesingh, Devindra S
Bhumireddy, Geetha P
Mohamed, Ambreen
Asfour, Ahmed
Briggs, William M
Ho, Jean
Khan, Saadat A
Grossman, Alexandra
Klem, Igor
Sacchi, Terrence J
Heitner, John F
Journal Article
United States
Circ Cardiovasc Imaging. 2017 Sep;10(9):e006174. doi:
10.1161/CIRCIMAGING.117.006174.
PY - 2017
SN - 1941-9651
ST - Prevalence and Prognostic Significance of Left Ventricular Noncompaction in
Patients Referred for Cardiac Magnetic Resonance Imaging
T2 - Circ Cardiovasc Imaging
TI - Prevalence and Prognostic Significance of Left Ventricular Noncompaction in
Patients Referred for Cardiac Magnetic Resonance Imaging
VL - 10
ID - 2806
ER -
TY - JOUR
AB - INTRODUCTION: Sudden cardiac death is an unexpected natural death from
cardiac causes. It is the most common and first manifestation of coronary artery
disease. It accounts for 50% of mortality from cardiovascular disease in the United
States of America and other developed countries, so measures that can reduce it are
an important medical task. CASE REPORT: A 55-year old man suddenly lost
consciousness at the train station in Novi Sad. An eyewitness provided first aid
and ventricular fibrillation was converted to sinus rhythm by means of the
automated external defibrillator. Emergency Medical Service Novi Sad soon arrived,
continued resuscitation procedure, and transported the patient to the Cardiac Care
Unit, who was then diagnosed with acutedmyocardial infarction and primary
percutaneous coronary intervention was performed. Resuscitative hypothermia was
applied in acute phase to prevent further brain injury. During further
hospitalization the patient was stable, woke up from coma and early rehabilitation
measures were implemented. After six months the patient had normal physical
activities and there was no left ventricular segmental hypokinesia on echo
cardiography. CONCLUSION: The application of all four chains of survival is
important in increasing the survival rate of patients with sudden cardiac arrest.
AN - 29693905
AU - Ivanov, I.
AU - Dejanovic, J.
AU - Cankovic, M.
AU - Ivanovic, V.
AU - Vulin, A.
AU - Obradovic, D.
DA - Jul
DO - 10.2298/mpns1608237i
DP - NLM
ET - 2016/07/01
IS - 7-8
J2 - Medicinski pregled
KW - *Defibrillators
Humans
Male
Middle Aged
Serbia
LA - eng
N1 - Ivanov, Igor
Dejanovic, Jadranka
Cankovic, Milenko
Ivanovic, Vladimir
Vulin, Aleksandra
Obradovic, Dusanka
Case Reports
Journal Article
Serbia
Med Pregl. 2016 Jul;69(7-8):237-240. doi: 10.2298/mpns1608237i.
PY - 2016
SN - 0025-8105 (Print)
0025-8105
SP - 237-240
ST - FIRST APPLICATION OF AUTOMATED EXTERNAL DEFIBRILATOR IN SERBIA - CASE REPORT
T2 - Med Pregl
TI - FIRST APPLICATION OF AUTOMATED EXTERNAL DEFIBRILATOR IN SERBIA - CASE REPORT
VL - 69
ID - 2907
ER -
TY - JOUR
AB - AIMS: Subclinical brain damage due to microembolization could occur during
catheter ablation procedures. We evaluated the microembolic signals (MESs) detected
by transcranial Doppler during ablation of supraventricular tachycardias (SVTs) or
idiopathic ventricular arrhythmias (VAs) with the use of different approaches.
METHODS AND RESULTS: This study included 36 patients (23 men, 49 ± 21 years) who
underwent catheter ablation of SVTs (n = 27) or idiopathic VAs (n = 9). Left-sided
ablation was performed by either a transaortic (Group 1, n = 11) or transseptal
approach (Group 2, n = 9). A sole right-sided ablation was performed in the
remaining 16 patients (Group 3). The MESs were counted throughout the procedure,
and then analysed offline with a frequency analysis. The mean number of
radiofrequency applications, total energy delivery time, total application energy,
and total procedure time were 5.8 ± 5.0, 4.3 ± 3.3 min, 6625 ± 4633 J, and 81 ± 40
min, respectively, and there was no significant difference in the parameters
between the three groups. The mean total number of MESs was 3.8 ± 3.1 in Group 1,
75 ± 58 in Group 2, and 0.3 ± 0.6 in Group 3 (P = 0.001). Few MESs were detectable
during the radiofrequency energy deliveries in all groups. In Group 2, 19 ± 18 MESs
were detected during the transseptal puncture period, and subsequently a relatively
even distribution of emboli formation was observed. A frequency analysis suggested
that 99, 91, and 100% of MESs were gaseous, in Group 1, Group 2, and Group 3,
respectively. No neurological impairment was observed in any patients after the
procedure. CONCLUSION: The retrograde aortic approach might potentially have a
lower risk of subclinical brain damage than the transseptal approach during left-
sided catheter ablation.
AD - Cardiology Division, Cardiovascular Center, Tsuchiura Kyodo Hospital, 11-7
Manabeshin-machi, Tsuchiura, Ibaraki 300-0053, Japan.
AN - 28110301
AU - Iwasawa, J.
AU - Miyazaki, S.
AU - Takagi, T.
AU - Taniguchi, H.
AU - Nakamura, H.
AU - Hachiya, H.
AU - Iesaka, Y.
DA - Feb 1
DO - 10.1093/europace/euw397
DP - NLM
ET - 2017/01/23
IS - 2
KW - Adult
Aged
Cardiac Catheterization/*adverse effects/methods
Catheter Ablation/*adverse effects/methods
Female
Humans
Intracranial Embolism/*diagnostic imaging/etiology
Male
Middle Aged
Risk Factors
Tachycardia, Supraventricular/diagnosis/physiopathology/*surgery
Tachycardia, Ventricular/diagnosis/physiopathology/*surgery
Treatment Outcome
*Ultrasonography, Doppler, Transcranial
Ventricular Fibrillation/diagnosis/physiopathology/*surgery
*Catheter ablation
*Cerebral microembolism
*Transaortic approach
*Transcranial Doppler
*Transseptal approach
LA - eng
N1 - 1532-2092
Iwasawa, Jin
Miyazaki, Shinsuke
Takagi, Takamitsu
Taniguchi, Hiroshi
Nakamura, Hiroaki
Hachiya, Hitoshi
Iesaka, Yoshito
Comparative Study
Journal Article
England
Europace. 2018 Feb 1;20(2):347-352. doi: 10.1093/europace/euw397.
PY - 2018
SN - 1099-5129
SP - 347-352
ST - Transcranial measurement of cerebral microembolic signals during left-sided
catheter ablation with the use of different approaches- the potential microembolic
risk of a transseptal approach
T2 - Europace
TI - Transcranial measurement of cerebral microembolic signals during left-sided
catheter ablation with the use of different approaches- the potential microembolic
risk of a transseptal approach
VL - 20
ID - 2803
ER -
TY - JOUR
AB - BACKGROUND AND PURPOSE: Inflammation is a major risk factor for
atherosclerotic plaque rupture and clinical events. Previous studies have shown
that plaque [(18)F]fluorodeoxyglucose (FDG) uptake correlates with macrophage
content. In this study we examined the reproducibility of 3 methods of quantifying
plaque FDG uptake in the carotid arteries using positron emission tomography (PET).
The correlation between 2 simplified uptake parameters (standardized uptake value
[SUV], vessel wall-to-blood ratio [VBR]) and a gold standard technique (influx rate
[K(i)]) was also determined. We used MRI to correct carotid plaque FDG uptake for
partial volume error. METHODS: Seven patients with a recent carotid territory
transient ischemic attack underwent imaging twice within 8 days using MR and FDG-
PET. MR coregistered to PET was used to delineate regions of interest, and to
facilitate partial volume correction (PVC). RESULTS: SUV was the most reproducible
parameter irrespective of whether it was normalized by body surface area (BSA),
lean body mass, or weight (intraclass correlation coefficient=0.85, 0.88, and 0.90,
respectively). VBR correlated better to K(i) than SUV (r=0.58 VBR, r=0.46
SUV(BSA)). PVC improved these correlations to r=0.81 VBR and r=0.76 SUV(BSA), and
only slightly degraded the reproducibility of SUV (intraclass correlation
coefficient=0.83-0.85). CONCLUSIONS: MR-guided FDG-PET is a highly reproducible
technique in the carotid artery and the excellent anatomic detail provided by MR
facilitates PVC. Of the methods examined, SUV(BSA)(PVC) appears to represent the
best compromise between reproducible and accurate determination of FDG metabolism
in carotid artery vessel wall.
AD - Wolfson Brain Imaging Centre, University of Cambridge, Box 65, Addenbrooke's
Hospital, Cambridge, CB2 0QQ, UK. di219@wbic.cam.ac.uk
AN - 18927453
AU - Izquierdo-Garcia, D.
AU - Davies, J. R.
AU - Graves, M. J.
AU - Rudd, J. H.
AU - Gillard, J. H.
AU - Weissberg, P. L.
AU - Fryer, T. D.
AU - Warburton, E. A.
DA - Jan
DO - 10.1161/strokeaha.108.521393
DP - NLM
ET - 2008/10/18
IS - 1
J2 - Stroke
KW - Aged
Arteritis/*diagnostic imaging/*pathology/physiopathology
Artifacts
Carotid Arteries/diagnostic imaging/pathology/physiopathology
Carotid Stenosis/*diagnostic imaging/*pathology/physiopathology
Chemotaxis, Leukocyte/immunology
Female
Fluorodeoxyglucose F18
Humans
Image Processing, Computer-Assisted/methods
Ischemic Attack, Transient/diagnostic imaging/pathology/physiopathology
Macrophages/pathology
Male
Middle Aged
Positron-Emission Tomography/*methods
Potassium/metabolism
LA - eng
N1 - 1524-4628
Izquierdo-Garcia, David
Davies, John R
Graves, Martin J
Rudd, James H F
Gillard, Jonathan H
Weissberg, Peter L
Fryer, Tim D
Warburton, Elizabeth A
FG/03/013/British Heart Foundation/United Kingdom
Comparative Study
Journal Article
United States
Stroke. 2009 Jan;40(1):86-93. doi: 10.1161/STROKEAHA.108.521393. Epub 2008 Oct 16.
PY - 2009
SN - 0039-2499
SP - 86-93
ST - Comparison of methods for magnetic resonance-guided [18-F]fluorodeoxyglucose
positron emission tomography in human carotid arteries: reproducibility, partial
volume correction, and correlation between methods
T2 - Stroke
TI - Comparison of methods for magnetic resonance-guided [18-F]fluorodeoxyglucose
positron emission tomography in human carotid arteries: reproducibility, partial
volume correction, and correlation between methods
VL - 40
ID - 2588
ER -
TY - JOUR
AB - INTRODUCTION: The impact of ventricular rate (VR) on the outcome of
electrical cardioversion (ECV) of acute atrial fibrillation (AF) is currently
unknown. We aimed to determine the effect of VR during acute AF on the success of
ECV, recurrence of AF, and occurrence of post-cardioversion complications in 30
days of follow-up. METHODS: A total of 6,624 ECVs were performed in 2,821
consecutive patients with AF lasting < 48 hours. VR ≤ 60 bpm was defined low, and
VR ≥ 160 bpm high. RESULTS: The median VR before ECV was 109 bpm. The success rate
of ECV was 94.2%. Bradycardia occurred in 62 (0.9%) and thromboembolic
complications in 39 (0.6%) ECVs. Low VR was observed before 75 (1.1%) ECVs, and
male sex was its only independent predictor. High VR was observed in 165 (2.5%)
ECVs. The independent predictors of high VR were younger age, < 12 h episode
duration, no previous history of AF, and alcohol abuse. Low or high VR were not
related to the success of ECV, incidence of thromboembolic or bradycardic
complications, or recurrence of AF, although VR was significantly (P < 0.001) lower
in the patients in whom AF recurred. CONCLUSION: VR during acute AF does not affect
the efficacy or safety of ECV.
AD - Heart Center, Turku University Hospital and University of Turku , Finland.
AN - 25943162
AU - Jaakkola, J.
AU - Hartikainen, J. E.
AU - Kiviniemi, T.
AU - Nuotio, I.
AU - Nammas, W.
AU - Grönberg, T.
AU - Karmi, A.
AU - Ylitalo, A.
AU - Airaksinen, K. E.
DA - Jun
DO - 10.3109/07853890.2015.1031821
DP - NLM
ET - 2015/05/07
IS - 4
J2 - Annals of medicine
KW - Aged
Atrial Fibrillation/epidemiology/physiopathology/*therapy
Bradycardia/epidemiology/physiopathology
Electric Countershock/adverse effects/*methods/statistics & numerical data
Female
Finland/epidemiology
Follow-Up Studies
Humans
Incidence
Male
Middle Aged
Stroke/epidemiology/physiopathology
Treatment Outcome
Atrial fibrillation
bradycardia
electric countershock
heart rate
stroke
LA - eng
N1 - 1365-2060
Jaakkola, Jussi
Hartikainen, Juha E K
Kiviniemi, Tuomas
Nuotio, Ilpo
Nammas, Wail
Grönberg, Toni
Karmi, Anna
Ylitalo, Antti
Airaksinen, K E Juhani
Clinical Trial
Journal Article
Multicenter Study
England
Ann Med. 2015 Jun;47(4):341-5. doi: 10.3109/07853890.2015.1031821. Epub 2015 May 6.
PY - 2015
SN - 0785-3890
SP - 341-5
ST - Ventricular rate during acute atrial fibrillation and outcome of electrical
cardioversion: The FinCV Study
T2 - Ann Med
TI - Ventricular rate during acute atrial fibrillation and outcome of electrical
cardioversion: The FinCV Study
VL - 47
ID - 2533
ER -
TY - JOUR
AB - Patients with hypertrophic cardiomyopathy may present with a number of
arrhythmias. Although not unique, arrhythmias in hypertrophic cardiomyopathy
require management approaches that may differ from other populations. Standard
permanent pacemaker indications can be seen, but unique applications and
implantation considerations pertain to this population. Ventricular and
supraventricular tachyarrhythmias may be experienced by patients with hypertrophic
cardiomyopathy, treatment for which must be tailored to the hypertrophic
cardiomyopathy substrate. In this article, permanent pacemaker indications,
techniques and special considerations, and specific management issues of
ventricular and supraventricular tachyarrhythmias in hypertrophic cardiomyopathy,
are discussed.
AD - Complex Arrhythmia Ablation Program, New York Medical College, Westchester
Medical Center, Macy 130, 100 Woods Road, Valahalla, NY 10595, USA. Electronic
address: Jason.Jacobson@wmchealth.org.
AN - 30447716
AU - Jacobson, J. T.
DA - Feb
DO - 10.1016/j.ccl.2018.08.005
DP - NLM
ET - 2018/11/19
IS - 1
J2 - Cardiology clinics
Arrhythmias, Cardiac/diagnosis/*therapy
Cardiomyopathy, Hypertrophic/diagnosis/therapy
Electrocardiography
Humans
Recurrence
Ventricular Outflow Obstruction/diagnosis/therapy
Atrial fibrillation
Hypertrophic cardiomyopathy
Pacemakers
Stroke
Ventricular arrhythmias
LA - eng
N1 - 1558-2264
Jacobson, Jason T
Journal Article
Review
Netherlands
Cardiol Clin. 2019 Feb;37(1):55-62. doi: 10.1016/j.ccl.2018.08.005. Epub 2018 Oct
29.
PY - 2019
SN - 0733-8651
SP - 55-62
ST - Arrhythmia Evaluation and Management
T2 - Cardiol Clin
TI - Arrhythmia Evaluation and Management
VL - 37
ID - 2304
ER -
TY - JOUR
AB - Risk for stroke in patients with atrial fibrillation (AF) is highly
heterogeneous. Increasing age, history of diabetes, hypertension, previous
transient ischemic attack or stroke, and poor ventricular function are independent
risk factors for stroke in patients with AF. Accordingly, some groups of patients
with AF have low risk and some have high risk. In general, patients at high risk
benefit most from anticoagulation therapy with warfarin. In general, if a patient
is younger than 65 years of age and has none of the defined risk factors, the
stroke rate without prophylaxis (aspirin or warfarin) is low. In patients 65 to 75
years of age with no risk factors, the risk for stroke is low with either aspirin
or warfarin therapy; the choice is left to the caretaking physician. All patients
older than 75 years and all patients of any age who have risk factors obtain
striking benefit from the use of anticoagulation with warfarin. This benefit far
outweighs any risk for major hemorrhage.
AD - Division of Cardiology, University of Iowa, Iowa City, USA.
AN - 10666662
AU - Jagasia, D. H.
AU - Williams, B.
DA - Jan
DO - 10.1097/00001573-200001000-00008
DP - NLM
ET - 2000/02/10
IS - 1
KW - Age Factors
Aged
Aspirin/*therapeutic use
Atrial Fibrillation/complications/diagnostic imaging/*drug therapy
Humans
Middle Aged
Risk Factors
LA - eng
N1 - Jagasia, D H
Williams, B
Ezekowitz, M D
Journal Article
Review
United States
Curr Opin Cardiol. 2000 Jan;15(1):58-63. doi: 10.1097/00001573-200001000-00008.
PY - 2000
SN - 0268-4705 (Print)
0268-4705
SP - 58-63
ST - Clinical implication of antiembolic trials in atrial fibrillation and role of
transesophageal echocardiography in atrial fibrillation
TI - Clinical implication of antiembolic trials in atrial fibrillation and role of
transesophageal echocardiography in atrial fibrillation
VL - 15
ID - 2671
ER -
TY - JOUR
AB - HISTORY: We report three male patients who had atrial fibrillation with a
rapid and irregular ventricular rate, aged 60, 69 and 70 years, respectively, in
whom development of acute pancreatitis occurred simultaneously with other ischaemic
events. INVESTIGATIONS: One of these patients simultaneously suffered from a
transient ischaemic attack (TIA), another developed a stroke and an infarction of
the spleen, while the third one had a splenic infarction and an embolism in the
region of the mesenteric arteries. Two patients had paroxysmal atrial fibrillation,
while the third suffered from ischemic cardiomyopathy with chronic atrial
fibrillation. DIAGNOSIS AND TREATMENT: Oedematous pancreatitis occurred in one
patient while, in the two others, the diagnosis of severe necrotizing pancreatitis
was made. CONCLUSION: Atrial fibrillation is the most common sustained arrhythmia
encountered in clinical practice and a recognized risk factor for the development
of peripheral embolism, which often takes the form of an ischaemic stroke. It is a
major cause of stroke, especially in the elderly. Because of the simultaneous
occurrence of thromboembolic events in all three patients, an ischaemic cause for
the acute pancreatitis can be assumed with a high degree of probability. This is
one of the first reports of acute ischaemic pancreatitis probably caused by
microembolization secondary to atrial fibrillation. Because of the relatively
frequent occurrence of atrial fibrillation, this factor deserves increased
attention in the differential diagnosis of supposedly idiopathic pancreatitis.
AD - Klinik für Innere Medizin, Krankenhaus Burg, Germany.
AN - 12481237
AU - Janowitz, P.
AU - Von Moltke, A.
AU - Weidmann, B.
DA - Dec 13
DO - 10.1055/s-2002-36113
DP - NLM
ET - 2002/12/14
IS - 50
KW - Acute Disease
Aged
Atrial Fibrillation/*complications/diagnosis/etiology
Humans
Ischemia/diagnosis/etiology
Male
Middle Aged
Pancreas/blood supply
Pancreatitis, Acute Necrotizing/diagnosis/*etiology
Risk Factors
Thromboembolism/diagnosis/etiology
LA - ger
N1 - Janowitz, P
Von Moltke, A
Weidmann, B
Case Reports
English Abstract
Journal Article
Germany
OP - Vorhofflimmern als mögliche Ursache für eine akute Pankreatitis?
PY - 2002
SN - 0012-0472 (Print)
0012-0472
SP - 2669-72
ST - [Acute pancreatitis caused by atrial fibrillation?]
TI - [Acute pancreatitis caused by atrial fibrillation?]
VL - 127
ID - 2659
ER -
TY - JOUR
AN - 24685669
AU - January, C. T.
AU - Wann, L. S.
AU - Alpert, J. S.
AU - Calkins, H.
AU - Cigarroa, J. E.
AU - Cleveland, J. C., Jr.
AU - Conti, J. B.
AU - Ellinor, P. T.
AU - Field, M. E.
AU - Murray, K. T.
AU - Sacco, R. L.
AU - Stevenson, W. G.
AU - Tchou, P. J.
AU - Tracy, C. M.
AU - Yancy, C. W.
DA - Dec 2
DO - 10.1016/j.jacc.2014.03.022
DP - NLM
ET - 2014/04/02
IS - 21
Atrial Fibrillation/classification/physiopathology/*therapy
Autonomic Nervous System/physiopathology
Cardiac Output, Low/physiopathology
Catheter Ablation
Comorbidity
Electrocardiography
Heart Atria/abnormalities/physiopathology/surgery
Humans
Inflammation/physiopathology
Oxidative Stress/physiology
Renin-Angiotensin System/physiology
Risk Assessment
Risk Factors
Septal Occluder Device
Thromboembolism/physiopathology/prevention & control
Ventricular Remodeling/physiology
AHA Scientific Statements
atrial fibrillation
cardio-renal physiology/pathophysiology
cardiovascular surgery: transplantation, ventricular assistance, cardiomyopathy
epidemiology
full revision
health policy and outcome research
other atrial fibrillation
LA - eng
N1 - 1558-3597
January, Craig T
Wann, L Samuel
Alpert, Joseph S
Calkins, Hugh
Cigarroa, Joaquin E
Cleveland, Joseph C Jr
Conti, Jamie B
Ellinor, Patrick T
Field, Michael E
Murray, Katherine T
Sacco, Ralph L
Stevenson, William G
Tchou, Patrick J
Tracy, Cynthia M
Yancy, Clyde W
American College of Cardiology/American Heart Association Task Force on Practice
Guidelines
Journal Article
Practice Guideline
Review
United States
J Am Coll Cardiol. 2014 Dec 2;64(21):e1-76. doi: 10.1016/j.jacc.2014.03.022. Epub
2014 Mar 28.
PY - 2014
SN - 0735-1097
SP - e1-76
ST - 2014 AHA/ACC/HRS guideline for the management of patients with atrial
fibrillation: a report of the American College of Cardiology/American Heart
Association Task Force on Practice Guidelines and the Heart Rhythm Society
TI - 2014 AHA/ACC/HRS guideline for the management of patients with atrial
fibrillation: a report of the American College of Cardiology/American Heart
Association Task Force on Practice Guidelines and the Heart Rhythm Society
VL - 64
ID - 2281
ER -
TY - JOUR
AB - This study examined whether different associations between risk factors and
atrial fibrillation (AF) according to race could explain the lower incidence of AF
in blacks. Baseline risk factor information was obtained from interviews, clinical
examinations, and echocardiography in 4,774 white and 911 black Cardiovascular
Health Study participants aged 65 and older without a history of AF at baseline in
1989/90 or 1992/93. Incident AF was determined according to hospital discharge
diagnosis or annual study electrocardiogram. Cox regression was used to assess
associations between risk factors and race and incident AF. During a mean 11.2
years of follow-up, 1,403 whites and 182 blacks had incident AF. Associations
between all examined risk factors were similar in both races, except left
ventricular posterior wall thickness, which was more strongly associated with AF in
blacks (per 0.2 cm, blacks: hazard ratio (HR) = 1.72, 95% confidence interval (CI)
= 1.44-2.06; whites: HR = 1.30, 95% CI = 1.18-1.43). Overall, the relative risk of
AF was 25% lower in blacks than whites after adjustment for age and sex (HR = 0.75,
95% CI = 0.64-0.87) and 45% lower after adjustment for all considered risk factors
(HR = 0.55, 95% CI = 0.35-0.88). Different associations of the considered risk
factors and incident AF by race do not explain the lower incidence of AF in blacks.
AD - Department of Cardiovascular Health Research Unit, University of Washington,
Seattle, Washington, USA. pnjensen@uw.edu
AN - 23320758
AU - Jensen, P. N.
AU - Thacker, E. L.
AU - Dublin, S.
AU - Psaty, B. M.
AU - Heckbert, S. R.
C2 - PMC3878638
C6 - NIHMS537437 checklist provided by the authors and has determined that the
authors have no financial or any other kind of personal conflicts with this paper.
DA - Feb
DO - 10.1111/jgs.12085
DP - NLM
ET - 2013/01/17
IS - 2
J2 - Journal of the American Geriatrics Society
KW - Aged
Atrial Fibrillation/complications/*ethnology
*Continental Population Groups
Female
Follow-Up Studies
Humans
Incidence
Male
Prevalence
Risk Factors
Stroke/*ethnology/etiology
LA - eng
N1 - 1532-5415
Jensen, Paul N
Thacker, Evan L
Dublin, Sascha
Psaty, Bruce M
Heckbert, Susan R
T32 HL007902/HL/NHLBI NIH HHS/United States
R01 AG015928/AG/NIA NIH HHS/United States
K23AG028954/AG/NIA NIH HHS/United States
HHSN268200800007C/HL/NHLBI NIH HHS/United States
AG-20098/AG/NIA NIH HHS/United States
N01 HC-55222/HC/NHLBI NIH HHS/United States
HHSN268201200036C/HL/NHLBI NIH HHS/United States
Comparative Study
Journal Article
Multicenter Study
J Am Geriatr Soc. 2013 Feb;61(2):276-80. doi: 10.1111/jgs.12085. Epub 2013 Jan 15.
PY - 2013
SN - 0002-8614 (Print)
0002-8614
SP - 276-80
ST - Racial differences in the incidence of and risk factors for atrial
fibrillation in older adults: the cardiovascular health study
T2 - J Am Geriatr Soc
TI - Racial differences in the incidence of and risk factors for atrial
fibrillation in older adults: the cardiovascular health study
VL - 61
ID - 2685
ER -
TY - JOUR
AB - OBJECTIVE: To introduce the technique of intracardiac operations performed in
beating heart through mini-thoracotomy. METHOD: >From March 1995 to June 1997,
intracardiac operations were performed in beating heart through right subaxillary
anterolateral mini-thoracotomy with normothermic extracorporeal circulation in 34
patients. 16 patients had atrial septal defect, 14 ventricular septal defect, 2
mitral insufficiency, 1 right coronary artery-right ventricular fistula, and 1
Ebstein's anomaly. RESULT: The mean cardiopulmonary bypass time was 22.54 minutes.
There were no embolism, arrhythmia and cerebral complications. Postoperative
hospital stay was 8.0 +/- 2.2 days. All the patients had no heart murmur and
residual shunt, and enjoyed a full range of physical activities in a follow-up of 2
to 26 months. CONCLUSION: Intracardiac operations performed in beating heart
through right subaxillary anterolateral mini-thoracotomy appears to be less
invasive, simple, safe and cosmetic.
AD - Department of Cardiac Surgery, General Hospital of Beijing Military Region,
People's Liberation Army, Beijing 100700.
AN - 11825411
AU - Jia, Q.
AU - Yao, J.
AU - Cheng, Q.
AU - Lu, N.
AU - Niu, J.
AU - Zhao, X.
AU - Zhang, X.
AU - Li, W.
DA - Jun
DP - NLM
ET - 2002/02/05
IS - 6
J2 - Zhonghua wai ke za zhi [Chinese journal of surgery]
KW - Adolescent
Adult
Cardiac Surgical Procedures/*methods
Child
Child, Preschool
Extracorporeal Circulation
Female
Follow-Up Studies
Heart Defects, Congenital/*surgery
Humans
Male
Minimally Invasive Surgical Procedures
Thoracotomy/*methods
LA - chi
N1 - Jia, Q
Yao, J
Cheng, Q
Lu, N
Niu, J
Zhao, X
Zhang, X
Li, W
English Abstract
Journal Article
China
Zhonghua Wai Ke Za Zhi. 1998 Jun;36(6):358-9.
PY - 1998
SN - 0529-5815 (Print)
0529-5815
SP - 358-9
ST - [Intracardiac operations performed in beating heart through mini-thoracotomy
in 34 patients]
T2 - Zhonghua Wai Ke Za Zhi
TI - [Intracardiac operations performed in beating heart through mini-thoracotomy
in 34 patients]
VL - 36
ID - 3077
ER -
TY - JOUR
AB - Atrial fibrillation (AF), the most common form of arrhythmia, is associated
with the prevalence of many common cardiovascular and cerebrovascular diseases.
Catheter ablation is considered the first-line therapy for AF; however, AF
recurrence is very common after catheter ablation. Studies have been performed to
analyze the factors associated with AF recurrence, but none have reached a
consistent conclusion on whether left ventricular ejection fraction (LVEF) and left
atrial diameter (LA diameter) affect AF recurrence after catheter ablation.The
databases PubMed, Embase, and the Cochrane Library were used to search for relevant
studies up to September 2017. RevMan 5.3.5 software provided by the Cochrane
Collaboration Network was used to conduct this meta-analysis.Thirteen studies
involving 2825 patients were included in this meta-analysis. Overall, the results
revealed that elevated LA diameter values were significantly associated with AF
recurrence in patients after catheter ablation (MD = 2.19, 95% CI: 1.63-2.75, P
< .001), while baseline LVEF levels were not significantly positively associated
with AF recurrence in patients after catheter ablation (MD = -0.91, 95% CI: -1.18
to 1.67, P = .14).Overall, elevated LA diameter may be associated with AF
recurrence after catheter ablation; however, there was no direct relationship
between LVEF values and AF recurrence after catheter ablation when baseline LVEF
values are normal or mildly decreased. Besides, because of publication bias,
further studies should be performed to explore the mechanisms underlying AF
recurrence.
AD - Second School of Clinical Medicine, Guangzhou Univ Chinese Med.
Department of Orthopedics, Second Affiliated Hospital of Guangzhou Univ Chinese Med
(Guangdong Provincial Hospital of Chinese Medicine).
Beijing University of Chinese Medicine, Beijing, China.
Department of Cardiology, Second Affiliated Hospital of Guangzhou Univ Chinese Med
(Guangdong Provincial Hospital of Chinese Medicine).
AN - 29768386
AU - Jin, X.
AU - Pan, J.
AU - Wu, H.
AU - Xu, D.
C2 - PMC5976293 no conflicts of interest to disclose.
DA - May
DO - 10.1097/md.0000000000010822
DP - NLM
ET - 2018/05/17
IS - 20
J2 - Medicine
KW - Atrial Fibrillation/pathology/*physiopathology/*surgery
*Catheter Ablation
Humans
Recurrence
Risk Factors
*Stroke Volume
LA - eng
N1 - 1536-5964
Jin, Xiao
Pan, Jianke
Wu, Huanlin
Xu, Danping
Journal Article
Meta-Analysis
Medicine (Baltimore). 2018 May;97(20):e10822. doi: 10.1097/MD.0000000000010822.
PY - 2018
SN - 0025-7974 (Print)
0025-7974
SP - e10822
ST - Are left ventricular ejection fraction and left atrial diameter related to
atrial fibrillation recurrence after catheter ablation?: A meta-analysis
TI - Are left ventricular ejection fraction and left atrial diameter related to
atrial fibrillation recurrence after catheter ablation?: A meta-analysis
VL - 97
ID - 2817
ER -
TY - JOUR
AB - Objective: To explore the risk factors and prognoses of new-onset atrial
fibrillation (NOAF) in patients with acute myocardial infarction (AMI). Methods: A
total of 468 patients with AMI were admitted into Beijing Anzhen Hospital for
emergency pereutaneous coronary intervention (PCI). According to the NOAF occurred
during hospitalization, the patients were divided into two groups: the NOAF (n=37)
group and the non-NOAF (n=431) group. Parameters including general clinical
conditions, coronary lesions, echocardiography, biochemical markers, C-reactive
protein (CRP) , N-terminal pro-brain natriuretic peptide (NT-pro-BNP), and
myocardial markers were collected. In-hospital mortality and incidence of in-
hospital main adverse cardiovascular and cerebrovascular events (MACCE) were
compared between the two groups. Logistic multivariate regression analyses were
performed for the association between the risk factors and NOAF. Results: The
incidence of NOAF was 7.9% in AMI patients undergoing emergency PCI. There were no
significant differences in door-to-balloon time, weight, platelet counts, baseline
serum creatinine (SCr), postoperative SCr, triglyceride, total cholesterol, low
density lipoprotein cholesterol, high density lipoprotein cholesterol, uric acid,
glycosylated hemoglobin A1c, preoperative medication, number of lesions, thrombus
aspiration, location of myocardial infarction, and history of hypertension,
diabetes, peripheral vascular disease and old myocardial infarction between the two
groups. The percentage of women was in the NOAF group (32.4% vs. 16.7%, P<0.05) and
subjects in this group were significantly elder than those in the non-NOAF groups
[(66±10) years vs. (571±11) years, P<0.001]. Moreover, the levels of no-reflow rate
(40.5% vs. 12.6%, P<0.001) , CRP [25.2 (15.43, 29.97) mg/L vs.5.21 (2.33, 16.98)
mg/L, P<0.001], white blood cell counts [(11.19±3.44)×10(9) vs. (9.91±3.23)×10(9),
P=0.022], NT-pro-BNP [(652.6±108.8) ng/L vs. (258.3±105.9) ng/L, P<0.001], and
troponin I (TnI) [20.41(1.78, 87.89) μg/L vs.7.72(1.29, 36.39) μg/L, P=0.006] were
significantly higher in the NOAF group than in the non-NOAF group, while left
ventricular ejection fraction [(47.70±7.34)% vs. (53.35±8.05)%, P<0.001], and
hemoglobin [137.0(125.5, 146.0) g/L vs.144.0(133.0,156.0) g/L, P=0.042] were
significantly lower in the NOAF group than the non-NOAF group. Patients in the NOAF
group had significantly longer hospital stay than those in the non-NOAF group
[(8.7±5.6) d vs. (6.0±2.3) d, P=0.007]. The in-hospital mortality (8.1% vs 1.4%
P=0.004) and the incidence of in-hospital MACCE (37.8% vs. 7.7%, P<0.001) in the
NOAF group were significantly higher than those in the non-NOAF group. Logistic
multivariate regression analyses showed that age (HR 1.083, 95%CI 1.028-1.141,
P=0.003), CRP (HR 1.116, 95%CI 1.049-1.187, P=0.001), NT-pro-BNP (HR 1.463, 95%CI
1.001-4.064, P=0.001) and no-reflow (HR 4.388, 95%CI 1.006-19.144, P=0.049) were
independent predictors of NOAF after AMI. Conclusions: Age, elevated levels of CRP,
NT-pro-BNP, and the absence of no-reflow are risk factors for incident NOAF in
patients with AMI in hospital.
AD - Emergency Crisis Center, Beijing Anzhen Hospital of the Capital Medical
University, Beijing 100029, China.
Department of Cardiology, Beijing Anzhen Hospital of the Capital Medical
AN - 30704200
AU - Jin, Y. Y.
AU - Bai, R.
AU - Ye, M.
AU - Ai, H.
AU - Zeng, Y. J.
AU - Nie, S. P.
DA - Feb 1
DO - 10.3760/cma.j.issn.0578-1426.2019.02.010
DP - NLM
ET - 2019/02/02
IS - 2
KW - Aged
Atrial Fibrillation/blood/*epidemiology/*therapy
Biomarkers/blood
Female
Humans
Male
Middle Aged
Myocardial Infarction/*surgery
Percutaneous Coronary Intervention
Prognosis
Risk Factors
Atrial fibrillation
C-reactive protein
LA - chi
N1 - Jin, Y Y
Bai, R
Ye, M
Ai, H
Zeng, Y J
Nie, S P
Journal Article
China
Zhonghua Nei Ke Za Zhi. 2019 Feb 1;58(2):133-138. doi: 10.3760/cma.j.issn.0578-
1426.2019.02.010.
PY - 2019
SN - 0578-1426 (Print)
0578-1426
SP - 133-138
ST - [Risk factors and prognoses analysis of new-onset atrial fibrillation in
patients with acute myocardial infarction]
TI - [Risk factors and prognoses analysis of new-onset atrial fibrillation in
patients with acute myocardial infarction]
VL - 58
ID - 2967
ER -
TY - JOUR
AB - We report a 45-year-old woman with arrhythmogenic right ventricular dysplasia
(ARVD). Because of congestive heart failure and atrial fibrillation, she underwent
tricuspid valvular replacement and warfarin was prescribed. She suddenly had
dysarthria, left hemiparesis and left hemispatial neglect. After brain CT
examination, and cerebral angiography, she was diagnosed as cardiogenic brain
embolism and infusion of low molecular heparin was started. On day 25, she suddenly
had ventricular tachycardia and died in spite of treatment for arrhythmia. This is
the first report of the case of cardiogenic brain embolism following ARVD. In this
type of case, we must take care of arrhythmia besides the management of atrial
fibrillation and brain infarction.
AD - Department of Neurology, National Ureshino Hospital.
AN - 16318370
AU - Jinnouchi, J.
AU - Nakane, H.
AU - Kitayama, J.
AU - Fukahori, M.
AU - Ibayashi, S.
AU - Iida, M.
DA - Oct
DP - NLM
ET - 2005/12/02
IS - 10
J2 - Rinsho shinkeigaku = Clinical neurology
KW - Arrhythmogenic Right Ventricular Dysplasia/*complications
Brain Infarction/diagnostic imaging/*etiology
Fatal Outcome
Female
Humans
Middle Aged
LA - jpn
N1 - Jinnouchi, Juro
Nakane, Hiroshi
Kitayama, Jiro
Fukahori, Masami
Ibayashi, Setsuro
Iida, Mitsuo
Case Reports
Journal Article
Japan
Rinsho Shinkeigaku. 2005 Oct;45(10):744-7.
PY - 2005
SN - 0009-918X (Print)
0009-918x
SP - 744-7
ST - [A case of cardioembolic brain infarction in arrhythmogenic right ventricular
dysplasia]
T2 - Rinsho Shinkeigaku
TI - [A case of cardioembolic brain infarction in arrhythmogenic right ventricular
dysplasia]
VL - 45
ID - 2582
ER -
TY - JOUR
AB - A case of a patient with sustained ventricular tachycardia (VT) undergoing
implantable cardiovertor defibrillator (ICD) implantation, using transesophageal
echocardiography (TEE) and near infrared spectroscopy (NIR) is described. A 67-
year-old man with sustained VT associated with old myocardial infarction underwent
ICD implantation. Anesthesia was induced with fentanyl and propofol and maintained
with nitrous oxide, oxygen, sevoflurane, and fentanyl. Global hypokinesis of the
left ventricle was observed in the short-axis view provided by TEE. Intraoperative
systolic blood pressure was maintained between 100 and 120 mmHg, and cerebral
oxygenated hemoglobin (HbO2) was between 63% and 65%. During periods of induced
ventricular fibrillation, systolic blood pressure decreased to 60 mmHg, HbO2
decreased to 59%, and TEE revealed cardiac arrest. These changes were transient;
HbO2 returned to baseline values immediately after the restoration of normal
rhythm. TEE confirmed no remarkable change in cardiac function after defibrillation
testing. TEE and NIR were found to be beneficial for the anesthetic management of a
patient with sustained VT who was underdoing ICD implantation.
AD - Department of Anesthesiology, Tokushima University School of Medicine, 3-18-
15 Kuramoto, 770-8503, Tokushima, Japan.
AN - 15290423
AU - Jinnouchi, Y.
AU - Kawahito, S.
AU - Kitahata, H.
AU - Tanaka, K.
AU - Nozaki, J.
AU - Oshita, S.
DO - 10.1007/s00540-004-0243-7
DP - NLM
ET - 2004/08/04
IS - 3
J2 - Journal of anesthesia
KW - Aged
Anesthesia/*methods
Humans
Male
Spectroscopy, Near-Infrared
LA - eng
N1 - Jinnouchi, Yuka
Kawahito, Shinji
Kitahata, Hiroshi
Tanaka, Katsuya
Nozaki, Junpei
Oshita, Shuzo
Case Reports
Journal Article
Japan
J Anesth. 2004;18(3):220-3. doi: 10.1007/s00540-004-0243-7.
PY - 2004
SN - 0913-8668 (Print)
0913-8668
SP - 220-3
ST - Anesthetic management of a patient undergoing cardioverter defibrillator
implantation: usefulness of transesophageal echocardiography and near infrared
spectroscopy
T2 - J Anesth
TI - Anesthetic management of a patient undergoing cardioverter defibrillator
implantation: usefulness of transesophageal echocardiography and near infrared
spectroscopy
VL - 18
ID - 2925
ER -
TY - JOUR
AB - HISTORY: A 86-year-old man was referred as he developed a ventricular escape
rhythm and severe hypotension. Although external cardiac pacing was begun, the
patient subsequently needed intubation as of progressive cerebral deterioration. It
turned out that the patient had been treated with a combination compound including
hydrochlorothiazide 50 mg, amilorid 5 mg and timolol 20 mg daily for several years.
A second combination compound including verapamil 180 mg and trandolapril 2 mg
daily was added 5 days prior to hospitalisation due to insufficient control of
arterial hypertension. INVESTIGATIONS: At admission, the patient was comatose
without focal neurological findings. Laboratory analysis revealed lactic acidosis
and severe hyperkalemia. No evidence for acute coronary syndrome was found.
TREATMENT AND COURSE: Hyperkalemia was successfully treated using calcium
gluconate, insulin and glucose. External heart pacing and circulatory support using
epinephrine were ceased after conversion into a stable sinus rhythm. Renal failure
however did not resolve. CT-scans of the brain were performed on the third day as
of protracted coma. They showed extended infarction in the area of the left arteria
cerebri media with beginning brain edema. Although mechanical ventilation could be
stopped as of sufficient respiration, the patient died on the sixth day.
CONCLUSION: The presented case describes probably drug-associated severe
hyperkalemia and bradycardic arrhythmia, hypotension and (eventually preexisting)
normuric renal failure.
AD - Departement Pharmazie & Pharmakologie, Slotervaart Ziekenhuis/holländisches
Krebszentrum, Amsterdam, Niederlande. apmsj@slz.nl
AN - 15592972
AU - Joerger, M.
AU - Diethelm, M.
DA - Dec 10
DO - 10.1055/s-2004-836099
DP - NLM
ET - 2004/12/14
IS - 50
KW - Aged
Aged, 80 and over
Amiloride/administration & dosage
Angiotensin-Converting Enzyme Inhibitors/administration & dosage
Antihypertensive Agents/*administration & dosage
Calcium Channel Blockers/administration & dosage
Cerebral Infarction/diagnosis/diagnostic imaging
Diuretics/administration & dosage
Drug Combinations
Humans
Hydrochlorothiazide/administration & dosage
Hypertension/*drug therapy
Hypotension/chemically induced
Indoles/administration & dosage
Male
*Polypharmacy
Sodium Chloride Symporter Inhibitors/administration & dosage
Timolol/administration & dosage
Verapamil/administration & dosage
LA - ger
N1 - Joerger, M
Diethelm, M
Case Reports
Comparative Study
Journal Article
Germany
OP - Letale Polypharmazie bei einem Hypertoniker.
PY - 2004
SN - 0012-0472 (Print)
0012-0472
SP - 2714-6
ST - [Lethal polypharmacy in a patient with arterial hypertension]
TI - [Lethal polypharmacy in a patient with arterial hypertension]
VL - 129
ID - 2927
ER -
TY - JOUR
AB - Alterations of normal intra- and interatrial conduction are a common outcome
of multiple cardiovascular conditions. They arise most commonly in the context of
advanced age, cardiovascular risk factors, organic heart disease, atrial fibrosis,
and left atrial enlargement. Interatrial block (IAB), the most frequent and
extensively studied atrial conduction disorder, affects up to 20% of the general
primary care population. IAB can be partial (P wave duration ≥ 120 ms on any of the
12 ECG leads) or advanced (P wave ≥ 120 ms and biphasic morphology (positive-
negative) in inferior leads). Advanced IAB is an independent risk factor for
supraventricular tachyarrhythmias and embolic stroke in a variety of clinical
settings. Advanced IAB is a cause of left atrial electromechanical dysfunction and
left atrioventricular dyssynchrony and has been associated with left ventricular
diastolic dysfunction. P wave duration is associated with cardiovascular and all-
cause mortality in the general population. Atrial conduction abnormalities should
be identified as markers of atrial remodeling, prognostic indicators, and, in the
case of advanced IAB, a true arrhythmologic syndrome. IAB and other P wave
abnormalities should prompt the search for associated conditions, the treatment of
which may partially reverse atrial remodeling or prevent it if administered
upstream. Future studies will help define the role of preventive therapeutic
interventions in high-risk patients, including antiarrhythmic drug therapy and oral
anticoagulation. Implications for the treatment of heart failure and for pacing
should also be further investigated.
AD - Cardiology Division, Geneva University Hospital, Rue Gabrielle-Perret-Gentil
4, 1205, Geneva, Switzerland.
Cardiology Division, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4,
1205, Geneva, Switzerland. dipen.shah@hcuge.ch.
AN - 30128800
AU - Johner, N.
AU - Namdar, M.
AU - Shah, D. C.
DA - Aug
DO - 10.1007/s10840-018-0413-4
DP - NLM
ET - 2018/08/22
IS - 3
KW - Anti-Arrhythmia Agents/*administration & dosage
Atrial Fibrillation/diagnostic imaging/mortality/therapy
Atrial Flutter/diagnostic imaging/mortality/therapy
Cardiac Conduction System Disease/*diagnostic imaging/*drug therapy/mortality
Female
Heart Atria/*physiopathology
Heart Block/*diagnostic imaging/drug therapy/physiopathology
Humans
Male
Prognosis
Survival Rate
Atrial fibrillation
Atrial flutter
Conduction block
Heart failure
Interatrial block
Stroke
Thromboembolism
LA - eng
N1 - 1572-8595
Johner, Nicolas
Namdar, Mehdi
Shah, Dipen C
173007/Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen
Forschung/
Journal Article
Review
Netherlands
J Interv Card Electrophysiol. 2018 Aug;52(3):293-302. doi: 10.1007/s10840-018-0413-
4. Epub 2018 Aug 20.
PY - 2018
SN - 1383-875x
SP - 293-302
ST - Intra- and interatrial conduction abnormalities: hemodynamic and arrhythmic
significance
TI - Intra- and interatrial conduction abnormalities: hemodynamic and arrhythmic
significance
VL - 52
ID - 2317
ER -
TY - JOUR
AB - 4-aminopyridine (4-AP) is an orphan drug in the United States. It enhances
neuronal conduction at synapses and is indicated in the treatment of selected
neuromuscular disorders, including multiple sclerosis and myasthenia gravis, among
others. Its documented toxicity generally has been limited to central nervous
system (CNS) hyperexcitation and gastrointestinal upset. In this case, a 56-year-
old man accidentally overdosed on an unknown amount of generic 4-AP. This history
was unknown by his family and unavailable to initial providers. Approximately 1 h
after ingestion, his son found him diaphoretic, vomiting, and having unintelligible
speech. In the ensuing 2-3 h, the patient became moderately hypothermic (32.8
degrees C; 91 degrees F), developed atrial fibrillation with a rapid ventricular
response, and had neurological changes that were confused with an acute
cerebrovascular accident. After a 36-h stay in the intensive care unit that
included mechanical ventilation, cardioversion, passive rewarming, and an extensive
medical workup, the patient recovered without sequelae. After extubation he stated
that he thought he may have ingested too much 4-AP after rubbing a large amount of
it against a sore tooth to take advantage of its local analgesic properties. This
case of 4-AP overdose resulting in atrial fibrillation with rapid ventricular
response, hypothermia, and acute neurological changes mistaken for an acute
cerebrovascular accident is an unusual one. This case shows that overdose of 4-AP
can cause or mimic several serious medical conditions, and that a detailed history
and physical examination are essential for uncovering unusual diagnoses.
AD - Department of Emergency Medicine, Regions Hospital, St. Paul, Minnesota,
55101, USA.
AN - 16567254
AU - Johnson, N. C.
AU - Morgan, M. W.
DA - Feb
DO - 10.1016/j.jemermed.2005.04.020
DP - NLM
ET - 2006/03/29
IS - 2
KW - 4-Aminopyridine/*adverse effects
Accidents
Atrial Fibrillation/chemically induced
Drug Overdose/diagnosis
Drugs, Generic
Humans
Hypothermia/chemically induced
Male
Middle Aged
Potassium Channel Blockers/*adverse effects
Speech Intelligibility/drug effects
Stroke/diagnosis
LA - eng
N1 - Johnson, Nicholas C
Morgan, Matthew W
Case Reports
Journal Article
United States
J Emerg Med. 2006 Feb;30(2):175-7. doi: 10.1016/j.jemermed.2005.04.020.
PY - 2006
SN - 0736-4679 (Print)
0736-4679
SP - 175-7
ST - An unusual case of 4-aminopyridine toxicity
T2 - J Emerg Med
TI - An unusual case of 4-aminopyridine toxicity
VL - 30
ID - 2700
ER -
TY - JOUR
AB - Nonrheumatic atrial fibrillation (AF) frequently coexists with other risk
factors for cerebral ischemia. This study was originally designed to determine
which combinations of clinical and echocardiographic abnormalities were most
closely associated with the risk of cerebral ischemic events. Patients with
cerebral ischemic events (n = 214) and community-based control subjects (n = 201)
underwent transesophageal echocardiography and carotid artery imaging. Adjusted
odds ratios (ORs) were determined using multiple logistic regression analysis.
Independent risk factors for cerebral ischemia included diabetes, carotid stenosis,
aortic sclerosis, left ventricular dysfunction, left ventricular hypertrophy, left
atrial (LA) spontaneous contrast, and proximal aortic atheroma. Nonrheumatic AF in
combination with LA spontaneous contrast and LA enlargement showed a strong
association with cerebral ischemic events (OR 33.7 [95% confidence interval 4.53 to
251]). In subjects with sinus rhythm or nonrheumatic AF, LA enlargement was not
associated with an increased risk of cerebral ischemic events in the absence of LA
spontaneous contrast. However, only 2 patients and 1 control subject had
nonrheumatic AF without LA spontaneous contrast or LA enlargement. Therefore, study
of a larger number of subjects is required to address the issue of whether
nonrheumatic AF itself carries increased risk. The combination of nonrheumatic AF
with LA spontaneous contrast is a potent risk factor for cerebral ischemia.
Ascertaining the risk factor in nonrheumatic AF requires adequate examination for
underlying cardiac, aortic, and carotid vascular disease. Transesophageal
echocardiography may contribute to this assessment.
AD - Alfred Hospital, Melbourne, Australia.
AN - 8752187
AU - Jones, E. F.
AU - Calafiore, P.
AU - McNeil, J. J.
AU - Tonkin, A. M.
AU - Donnan, G. A.
DA - Aug 15
DO - 10.1016/s0002-9149(96)00331-1
DP - NLM
ET - 1996/08/15
IS - 4
KW - Aortic Diseases/complications
Arteriosclerosis/complications
Atrial Fibrillation/*complications/diagnostic imaging
Carotid Arteries/diagnostic imaging
Carotid Stenosis/complications
Cerebrovascular Disorders/*etiology
Constriction, Pathologic/complications
*Contrast Media
Female
Humans
Logistic Models
Male
Middle Aged
Odds Ratio
Risk Factors
LA - eng
N1 - Jones, E F
Calafiore, P
McNeil, J J
Tonkin, A M
Donnan, G A
Journal Article
United States
Am J Cardiol. 1996 Aug 15;78(4):425-9. doi: 10.1016/s0002-9149(96)00331-1.
PY - 1996
SN - 0002-9149 (Print)
0002-9149
SP - 425-9
ST - Atrial fibrillation with left atrial spontaneous contrast detected by
transesophageal echocardiography is a potent risk factor for stroke
T2 - Am J Cardiol
TI - Atrial fibrillation with left atrial spontaneous contrast detected by
transesophageal echocardiography is a potent risk factor for stroke
VL - 78
ID - 2966
ER -
TY - JOUR
AB - Possible correlations between the circulatory and neurological responses to
cardiopulmonary resuscitation (CPR) and the influence of pre-arrest factors
(demographic data, medical history and aetiology of circulatory arrest) and arrest
factors (location of arrest, ECG configurations, and duration of resuscitation) on
the course of circulatory and neurological recovery were investigated in 111
victims of circulatory arrest. At the start of resuscitation 57 patients (Group I)
had some brain function and 54 (Group II) had no brain function. Sixty nine
patients (62%) had circulation restored but 54 (78%) were left with heart failure.
Forty one patients (39%) survived the first day, 26 (63%) with heart failure; only
34 (31%) were alive after 48 h, 17 (50%) with heart failure. Half of the patients
surviving 24 or 48 h had awakened. Consciousness returned in 32 patients (29%)
during the first 48 h, more frequently in Group I than in Group II. Patients in
Group I had a higher incidence of in-hospital arrest and had their circulation
restored more often than those in Group II. Survival and post-resuscitation heart
failure was alike in the groups. The pre-arrest factors explored did not modify the
circulatory or neurological outcome whereas initial ventricular fibrillation was
significantly related to recovery of consciousness. The revivability of spontaneous
circulation and of neurological functions was found thus mainly to be determined by
global ischaemia sustained prior to and during CPR.
AD - Bispebjerg Hospital, Copenhagen Health Services, Medical Department I,
Denmark.
AN - 9547843
AU - Jørgensen, E. O.
DA - Jan
DO - 10.1016/s0300-9572(97)00066-x
DP - NLM
ET - 1998/04/21
IS - 1
J2 - Resuscitation
KW - Aged
*Cardiopulmonary Resuscitation
Central Nervous System Diseases/epidemiology
Female
Heart Arrest/*epidemiology/*therapy
Humans
Male
Risk Factors
Survival Rate
Time Factors
Treatment Outcome
Ventricular Fibrillation/epidemiology/therapy
LA - eng
N1 - Jørgensen, E O
Journal Article
Ireland
Resuscitation. 1998 Jan;36(1):45-9. doi: 10.1016/s0300-9572(97)00066-x.
PY - 1998
SN - 0300-9572 (Print)
0300-9572
SP - 45-9
ST - Neurological and circulatory outcomes of cardiopulmonary resuscitation in
progress: influence of pre-arrest and arrest factors
T2 - Resuscitation
TI - Neurological and circulatory outcomes of cardiopulmonary resuscitation in
progress: influence of pre-arrest and arrest factors
VL - 36
ID - 2928
ER -
TY - JOUR
AB - The cardiac status of 102 consecutive black stroke patients entered to the
Medunsa Stroke Databank was determined. Cardiological examination, echocardiography
and a gated blood pool scan revealed structural and/or functional cardiac
abnormalities in 73.6% of patients. Rheumatic heart disease was diagnosed in 15.6%,
mitral valve prolapse in 5.8% and mitral annulus calcification in 4.9% of cases.
'Possible' cardiac sources of cerebral embolism were detected in 22.5% and
'definite' sources in 23.5% of patients. Hypertensive heart disease was diagnosed
in 35.2% and cardiomyopathy in 13.7% of the study population. Ischaemic heart
disease was present in 6.86%. Ultrasonography revealed ventricular bands in 29.4%
of patients. The high incidence of structural cardiac abnormalities detected by
non-invasive means is in keeping with recent studies in white stroke patients.
AD - Department of Neurology, Medical University of Southern Africa, Pretoria.
AN - 2688143
AU - Joubert, J.
AU - van Gelder, A. L.
AU - Darazs, B.
AU - Pilloy, W. J.
DA - Dec 16
DP - NLM
ET - 1989/12/16
IS - 12
J2 - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
KW - Adolescent
Adult
*African Continental Ancestry Group
Aged
Aged, 80 and over
Cerebrovascular Disorders/*complications
Echocardiography
Electrocardiography
Embolism/complications
Female
Humans
Male
Middle Aged
Prospective Studies
South Africa
LA - eng
N1 - Joubert, J
van Gelder, A L
Darazs, B
Pilloy, W J
Journal Article
Review
South Africa
S Afr Med J. 1989 Dec 16;76(12):657-64.
PY - 1989
SN - 0256-9574 (Print)
SP - 657-64
ST - The cardiovascular status of the black stroke patient
T2 - S Afr Med J
TI - The cardiovascular status of the black stroke patient
VL - 76
ID - 3035
ER -
TY - JOUR
AB - Obesity is increasingly more common in postindustrial societies, and the
burden of childhood obesity is increasing. The major effects of obesity on
cardiovascular (CV) health are mediated through the risk of metabolic syndrome
(insulin-resistance, dyslipidemia, and hypertension), such that an absence of these
risk factors in obese individuals may not be associated with increased mortality
risk. In individuals already diagnosed with chronic CV disease (CVD), the
overweight and class I obese have significant associations with improved survival.
However, this effect is attenuated by increases in cardiorespiratory fitness. The
negative effects of obesity on CV health manifest as accelerated progression of
atherosclerosis, higher rates of ventricular remodeling and a higher risk of
associated diseases, including stroke, myocardial infarction, and heart failure.
The most effective therapies at reversing CVD risk factors associated with obesity
have been dietary changes with exercise, especially through structured exercise
programs, such as cardiac rehabilitation.
AD - Department of Graduate Medical Education, Ocala Regional Medical Center,
Ocala, FL, USA - Sergey.kachur@gmail.com.
Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute,
Ochsner Clinic Foundation, New Orleans, LA, USA.
New York University School of Medicine, New York, NY, USA.
AN - 28150485
AU - Kachur, S.
AU - Lavie, C. J.
AU - de Schutter, A.
AU - Milani, R. V.
AU - Ventura, H. O.
DA - Jun
DO - 10.23736/s0026-4806.17.05022-4
DP - NLM
ET - 2017/02/06
IS - 3
J2 - Minerva medica
KW - Atrial Fibrillation/etiology
Cardiovascular Diseases/epidemiology/*etiology
Coronary Disease/etiology
Humans
Obesity/*complications/diagnosis
Risk Factors
Stroke/etiology
LA - eng
N1 - 1827-1669
Kachur, Sergey
Lavie, Carl J
de Schutter, Alban
Milani, Richard V
Ventura, Hector O
Journal Article
Review
Italy
Minerva Med. 2017 Jun;108(3):212-228. doi: 10.23736/S0026-4806.17.05022-4. Epub
2017 Feb 1.
PY - 2017
SN - 0026-4806
SP - 212-228
ST - Obesity and cardiovascular diseases
T2 - Minerva Med
TI - Obesity and cardiovascular diseases
VL - 108
ID - 2279
ER -
TY - JOUR
AB - Myocardial perfusion abnormality in the left ventricle is known to be
prognostic in patients with hypertrophic cardiomyopathy (HCM). Magnetic resonance
imaging and necropsy studies on HCM hearts revealed myocardial lesions
predominating in the area of ventricular septum-free wall junction. We assessed
perfusion abnormality in this area and correlated it with the prognosis of HCM
patients. We performed exercise Tc-99m tetrofosmin myocardial scintigraphy in 55
patients with nonobstructive HCM. Perfusion abnormalities were semiquantified using
a 5-point scoring system in small areas of anterior junctions of basal, mid, and
apical short axis views in addition to a conventional 17-segment model. All
patients were prospectively followed for sudden death, cardiovascular death and
hospitalization for heart failure or stroke associated with atrial fibrillation.
Cardiovascular events occurred in 10 patients during an average follow-up period of
5.7 years. Stress and rest scores from anterior junction, and conventional summed
stress score were significantly higher in patients with cardiovascular events than
without (all P < 0.05). Anterior junction stress score of >2 produced a sensitivity
of 50% and a specificity of 98% for cardiovascular events and was an independent
predictor (hazard ratio 8.33; 95% confidence interval, 1.61-43.5; P = 0.01), with
rest scores producing similar values, which were higher than summed stress score of
>8 (5.68; 1.23-26.3; P = 0.03). The absence of myocardial perfusion abnormality in
the narrow area of anterior junction differentiated HCM patients with low-risk.
AD - Department of Cardiology, Matsushita Memorial Hospital, Sotojima 5-55,
Moriguchi, Osaka 570-8540, Japan. kaimoto@zeus.eonet.ne.jp
AN - 22187199
AU - Kaimoto, S.
AU - Kawasaki, T.
AU - Kuribayashi, T.
AU - Yamano, M.
AU - Miki, S.
AU - Kamitani, T.
AU - Matsubara, H.
DA - Oct
DO - 10.1007/s10554-011-9994-z
DP - NLM
ET - 2011/12/22
IS - 7
KW - Adult
Aged
Cardiomyopathy, Hypertrophic/complications/*diagnostic
imaging/mortality/physiopathology
*Coronary Circulation
Disease Progression
Echocardiography
Exercise Test
Female
Humans
Male
Middle Aged
*Myocardial Perfusion Imaging
Organophosphorus Compounds
Organotechnetium Compounds
Prospective Studies
Radiopharmaceuticals
Risk Assessment
Risk Factors
Stroke/etiology
Time Factors
*Tomography, Emission-Computed, Single-Photon
Ventricular Septum/*diagnostic imaging/physiopathology
LA - eng
N1 - 1875-8312
Kaimoto, Satoshi
Kawasaki, Tatsuya
Kuribayashi, Toshiro
Yamano, Michiyo
Miki, Shigeyuki
Kamitani, Tadaaki
Matsubara, Hiroaki
Journal Article
United States
Int J Cardiovasc Imaging. 2012 Oct;28(7):1829-39. doi: 10.1007/s10554-011-9994-z.
Epub 2011 Dec 21.
PY - 2012
SN - 1569-5794
SP - 1829-39
ST - Myocardial perfusion abnormality in the area of ventricular septum-free wall
junction and cardiovascular events in nonobstructive hypertrophic cardiomyopathy
TI - Myocardial perfusion abnormality in the area of ventricular septum-free wall
junction and cardiovascular events in nonobstructive hypertrophic cardiomyopathy
VL - 28
ID - 2922
ER -
TY - JOUR
AB - OBJECTIVES: Left atrial (LA) dimension can predict atrial fibrillation (AF)
recurrence after catheter-based or surgical ablation. Pulmonary vein isolation
(PVI) may be a surgical option during aortic valve replacement (AVR) and/or
coronary artery bypass grafting (CABG), though consensus regarding patient
selection and late outcome is lacking. METHODS: We studied 160 patients (mean age
70 ± 9 years) with paroxysmal AF who underwent radiofrequency-based PVI during AVR
and/or CABG, and were followed up postoperatively for at least 6 months. Mean
preoperative LA dimension was 44 ± 7 mm. Serial echocardiography was performed to
evaluate left ventricular (LV) and LA dimensions, E/e', estimated systolic
pulmonary artery (PA) pressure and degree of valvular regurgitation. Follow-up was
completed with a mean duration of 47 ± 25 months. RESULTS: At the latest follow-up,
133 patients (83%) remained in sinus rhythm. Preoperative LA dimension was
independently associated with increased risk of AF recurrence at 6 months after
surgery [adjusted odds ratio 1.3 per 1-mm increase in LA dimension, 95% confidence
interval (CI) 1.1-1.6, P < 0.001]. Receiver-operating characteristic curve analysis
demonstrated an optimal cut-off value for preoperative LA dimension of 45 mm to
predict sinus rhythm restoration (98% for <45 mm vs 55% for ≥45 mm, P < 0.001).
Patients with LA dimension ≥45 mm had a significantly lower 5-year survival rate
(62 ± 7 vs 82 ± 7%, P = 0.025) and freedom from adverse events defined as cerebral
infarction/haemorrhage, admission for heart failure, catheter ablation and
permanent pacemaker implantation (58 ± 7 vs 91 ± 4%, P < 0.001). Multivariate
analysis showed that preoperative LA dimension ≥45 mm was independently associated
with adverse events (adjusted hazards ratio 2.4, 95% CI 1.2-5.1, P = 0.019). Serial
echocardiography demonstrated improvement in LV systolic function irrespective of
LA dimension, whereas patients with LA dimension ≥45 mm showed less improvement in
LA dimension and systolic PA pressure (interaction effect P < 0.001) and persistent
higher E/e' (group effect P < 0.001), along with aggravated tricuspid
regurgitation. CONCLUSIONS: In patients with paroxysmal AF related to aortic valve
disease and/or coronary artery disease, a dilated left atrium (≥45 mm) was
associated with inferior AF- and event-free survival after PVI, accompanied by
persistent abnormalities in cardiac and haemodynamic function. These findings may
assist patient selection for PVI during AVR and/or CABG.
AD - Department of Cardiovascular Surgery, Osaka University Graduate School of
Medicine, Suita, Japan Department of Cardiovascular Surgery, Japan Labor Health and
Welfare Organization Osaka Rosai Hospital, Sakai, Japan.
Department of Cardiovascular Surgery, Hyogo College of Medicine, Nishinomiya,
Japan.
Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine,
Suita, Japan.
Department of Cardiovascular Surgery, Japan Labor Health and Welfare Organization
Osaka Rosai Hospital, Sakai, Japan.
Department of Cardiovascular Surgery, Osaka Police Hospital, Osaka, Japan.
Department of Cardiovascular Surgery, Osaka National Hospital, Osaka, Japan.
Department of Cardiovascular Surgery, Fukui Cardiovascular Center, Fukui, Japan.
Department of Cardiovascular Surgery, Rinku General Medical Center, Izumisano,
Japan.
Department of Cardiovascular Surgery, Sakurabashi Watanabe Hospital, Osaka, Japan.
Department of Cardiovascular Surgery, Sakakibara Heart Institute of Okayama,
Okayama, Japan.
Departments of Biostatistics, Hyogo College of Medicine, Nishinomiya, Japan.
Suita, Japan yshksw2@gmail.com.
AN - 25612746
AU - Kainuma, S.
AU - Mitsuno, M.
AU - Toda, K.
AU - Funatsu, T.
AU - Nakamura, T.
AU - Miyagawa, S.
AU - Yoshikawa, Y.
AU - Fukushima, S.
AU - Yoshioka, D.
AU - Saito, T.
AU - Nishi, H.
AU - Takahashi, T.
AU - Sakaki, M.
AU - Monta, O.
AU - Matsue, H.
AU - Masai, T.
AU - Sakaguchi, T.
AU - Yoshitaka, H.
AU - Ueno, T.
AU - Kuratani, T.
AU - Daimon, T.
AU - Taniguchi, K.
AU - Miyamoto, Y.
AU - Sawa, Y.
DA - Nov
DO - 10.1093/ejcts/ezu532
DP - NLM
ET - 2015/01/24
IS - 5
KW - Aged
Aged, 80 and over
Coronary Artery Bypass/*adverse effects
Female
Heart Atria/*physiopathology
Heart Valve Prosthesis Implantation/*adverse effects
Humans
Male
Middle Aged
Pulmonary Veins/surgery
ROC Curve
Treatment Outcome
Left atrial remodelling
Non-mitral valve disease
Paroxysmal atrial fibrillation
Pulmonary vein isolation
LA - eng
N1 - 1873-734x
Kainuma, Satoshi
Mitsuno, Masataka
Toda, Koichi
Funatsu, Toshihiro
Nakamura, Teruya
Miyagawa, Shigeru
Yoshikawa, Yasushi
Fukushima, Satsuki
Yoshioka, Daisuke
Saito, Tetsuya
Nishi, Hiroyuki
Takahashi, Toshiki
Sakaki, Masayuki
Monta, Osamu
Matsue, Hajime
Masai, Takafumi
Sakaguchi, Taichi
Yoshitaka, Hidenori
Ueno, Takayoshi
Kuratani, Toru
Daimon, Takashi
Taniguchi, Kazuhiro
Miyamoto, Yuji
Sawa, Yoshiki
Osaka Cardiovascular Surgery Research (OSCAR) Group
Journal Article
Germany
Eur J Cardiothorac Surg. 2015 Nov;48(5):765-77; discussion 777. doi:
10.1093/ejcts/ezu532. Epub 2015 Jan 21.
PY - 2015
SN - 1010-7940
ST - Dilated left atrium as a predictor of late outcome after pulmonary vein
isolation concomitant with aortic valve replacement and/or coronary artery bypass
grafting†
TI - Dilated left atrium as a predictor of late outcome after pulmonary vein
isolation concomitant with aortic valve replacement and/or coronary artery bypass
grafting†
VL - 48
ID - 3042
ER -
TY - JOUR
AB - BACKGROUND AND PURPOSE: Patients with acute cerebrovascular events are
susceptible to serious cardiac arrhythmias, but data on the time course and the
determinants of their onset are scarce. METHODS: The prospective Stroke-Arrhythmia-
Monitoring-Database (SAMBA) assessed cardiac arrhythmias with need for urgent
evaluation and treatment in 501 acute neurovascular patients during the first 72
hours after admission to a monitored stroke unit. Arrhythmias were systematically
detected by structured processing of telemetric data. Time of arrhythmia onset and
predisposing factors were investigated. RESULTS: Significant cardiac arrhythmias
occurred in 25.1% of all patients. Incidence was highest during the first 24 hours
after admission. Serious arrhythmic tachycardia (ventricular or
supraventricular>130 beats/min) was more frequent than bradycardic arrhythmia
(sinus-node dysfunction, bradyarrhythmia, or atrioventricular block °II and °III).
Arrhythmias were independently associated with higher age and severer neurological
deficits as measured by the National Institutes of Health Stroke Scale on
admission. CONCLUSIONS: The risk for significant cardiac arrhythmia after an acute
cerebrovascular event is highest during the first 24 hours of care and declines
with time during the first 3 days. Along with established vascular risk factors,
the National Institutes of Health Stroke Scale may be considered for a stratified
allocation of monitoring capabilities. CLINICAL TRIAL REGISTRATION: URL:
www.clinicaltrials.gov. Unique identifier: NCT01177748.
AD - Department of Neurology, University Medical Center Erlangen, Schwabachanlage
6, 91054 Erlangen, Germany.
AN - 22961962
AU - Breuer, L.
AU - Kahl, N.
AU - Bobinger, T.
AU - Raaz-Schrauder, D.
AU - Huttner, H. B.
AU - Schwab, S.
AU - Köhrmann, M.
DA - Nov
DO - 10.1161/strokeaha.112.664318
DP - NLM
ET - 2012/09/11
IS - 11
J2 - Stroke
KW - Age Distribution
Age Factors
Aged
Aged, 80 and over
Arrhythmias, Cardiac/*epidemiology/*etiology
Female
Humans
Incidence
Male
Middle Aged
Prospective Studies
Time Factors
LA - eng
N1 - 1524-4628
Kallmünzer, Bernd
Breuer, Lorenz
Kahl, Nicolas
Bobinger, Tobias
Raaz-Schrauder, Dorette
Huttner, Hagen Bernhard
Schwab, Stefan
Köhrmann, Martin
Clinical Trial
Journal Article
United States
Stroke. 2012 Nov;43(11):2892-7. doi: 10.1161/STROKEAHA.112.664318. Epub 2012 Sep 6.
PY - 2012
SN - 0039-2499
SP - 2892-7
ST - Serious cardiac arrhythmias after stroke: incidence, time course, and
predictors--a systematic, prospective analysis
T2 - Stroke
TI - Serious cardiac arrhythmias after stroke: incidence, time course, and
predictors--a systematic, prospective analysis
VL - 43
ID - 2405
ER -
TY - JOUR
AB - Cardiac embolism accounts for an increasing proportion of ischemic strokes
and might multiply several-fold during the next decades. However, research points
to several potential strategies to stem this expected rise in cardioembolic stroke.
First, although one-third of strokes are of unclear cause, it is increasingly
accepted that many of these cryptogenic strokes arise from a distant embolism
rather than in situ cerebrovascular disease, leading to the recent formulation of
embolic stroke of undetermined source as a distinct target for investigation.
Second, recent clinical trials have indicated that embolic stroke of undetermined
source may often stem from subclinical atrial fibrillation, which can be diagnosed
with prolonged heart rhythm monitoring. Third, emerging evidence indicates that a
thrombogenic atrial substrate can lead to atrial thromboembolism even in the
absence of atrial fibrillation. Such an atrial cardiomyopathy may explain many
cases of embolic stroke of undetermined source, and oral anticoagulant drugs may
prove to reduce stroke risk from atrial cardiomyopathy given its parallels to
atrial fibrillation. Non-vitamin K antagonist oral anticoagulant drugs have
recently expanded therapeutic options for preventing cardioembolic stroke and are
currently being tested for stroke prevention in patients with embolic stroke of
undetermined source, including specifically those with atrial cardiomyopathy.
Fourth, increasing appreciation of thrombogenic atrial substrate and the common
coexistence of cardiac and extracardiac stroke risk factors suggest benefits from
global vascular risk factor management in addition to anticoagulation. Finally,
improved imaging of ventricular thrombus plus the availability of non-vitamin K
antagonist oral anticoagulant drugs may lead to better prevention of stroke from
acute myocardial infarction and heart failure.
AD - From the Clinical and Translational Neuroscience Unit, Feil Family Brain and
Mind Research Institute (H.K.) and Department of Neurology, Weill Cornell Medicine,
New York, NY (H.K.); and Department of Medicine and Population Health Research
Institute, McMaster University, Hamilton, Ontario, Canada (J.S.H.).
hok9010@med.cornell.edu.
From the Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind
Research Institute (H.K.) and Department of Neurology, Weill Cornell Medicine, New
York, NY (H.K.); and Department of Medicine and Population Health Research
Institute, McMaster University, Hamilton, Ontario, Canada (J.S.H.).
AN - 28154101
AU - Kamel, H.
AU - Healey, J. S.
C2 - PMC5312810
C6 - NIHMS840977
DA - Feb 3
DO - 10.1161/circresaha.116.308407
DP - NLM
ET - 2017/02/06
IS - 3
J2 - Circulation research
KW - Anticoagulants/administration & dosage
Atrial Fibrillation/diagnosis/epidemiology/therapy
Cardiac Surgical Procedures/methods
Clinical Trials as Topic/methods
Heart Diseases/diagnosis/*epidemiology/*therapy
Humans
Myocardial Infarction/diagnosis/epidemiology/therapy
Risk Factors
Stroke/diagnosis/*epidemiology/*therapy
Thromboembolism/diagnosis/*epidemiology/*therapy
*anticoagulants
*atrial cardiomyopathy
*atrial myopathy
*embolism
*heart failure
*stroke
unpaid consultant for Medtronic and iRhythm. Dr. Healey has received research
grants
from Medtronic, St. Jude Medical, Boston Scientific, Boehringer-Ingelheim, and
Bristol-Meiers Squibb, and has served on advisory boards for Boehringer-Ingelheim
and Bayer.
LA - eng
N1 - 1524-4571
Kamel, Hooman
Healey, Jeff S
K23 NS082367/NS/NINDS NIH HHS/United States
Journal Article
Review
Circ Res. 2017 Feb 3;120(3):514-526. doi: 10.1161/CIRCRESAHA.116.308407.
PY - 2017
SN - 0009-7330 (Print)
0009-7330
SP - 514-526
ST - Cardioembolic Stroke
T2 - Circ Res
TI - Cardioembolic Stroke
VL - 120
ID - 2278
ER -
TY - JOUR
AB - OBJECTIVE: The added value of coronary artery calcium (CAC) to SPET for
identification of multivessel CAD has not been studied yet. The aim of this
original study was to investigate CAC as an adjunct to gated single photon emission
tomography (GSPET) in the detection of multivessel coronary artery disease (CAD).
SUBJECTS AND METHODS: The study group consisted of 164 prospectively recruited
patients without known CAD-123 (75%) men and 60 (37%) women, having diabetes type
II, renal insufficiency, left ventricular dilatation and other cardiac problems
(arrhythmia, necessity of pharmacological stress test, etc.). The mean age of these
patients was 61±12 years (range 34-85 years). All these patients underwent GSPET
imaging, CAC score measurement, and coronary angiography. The percentage of
ischaemic myocardium, stress and rest left ventricular ejection fraction (LVEF),
and transient ischaemic dilation (TID) ratio were measured. RESULTS: Patients with
multivessel CAD had more frequently reversible defects in multiple territories,
severe ischaemia ≥10% of the left ventricle, stress worsening of the LVEF ≥5%, TID
ratio ≥1.17, and CAC score >1000. In the detection of multivessel CAD, the
sensitivity of combined assessment of perfusion, function, and CAC (i.e., multiple
and/or ≥10% ischaemia, and/or worsening of the LVEF ≥5%, and/or TID ratio ≥1.17,
and/or CAC score >1000) was significantly higher than the sensitivity of perfusion
alone or perfusion and function alone (81% vs. 55% and 65%, respectively, P<0.05).
Sensitivity of only CAC was low (41%). CONCLUSION: Sensitivity of combined
assessment of myocardial perfusion, function, and CAC was significantly higher than
sensitivity of perfusion alone or perfusion and function alone, suggesting better
identification of high-risk patients with CAD.
AD - International Clinical Research Centre, Center of Molecular Imaging, St.
Anne's FacultyHospital, Masaryk University, Pekařská 53, 656 91 Brno, Czech
Republic. vladimir.kincl@fnusa.cz.
AN - 25840570
AU - Kamínek, M.
AU - Metelková, I.
AU - Budíková, M.
AU - Koranda, P.
AU - Henzlova, L.
AU - Havel, M.
AU - Sovová, E.
AU - Kincl, V.
DA - Jan-Apr
DP - NLM
ET - 2015/04/05
IS - 1
J2 - Hellenic journal of nuclear medicine
KW - Adult
Aged
Aged, 80 and over
Calcium/*metabolism
Coronary Artery Disease/*diagnosis/*diagnostic imaging
Diabetes Complications/blood
Diabetes Mellitus, Type 2/blood
Female
Humans
Ischemia/pathology
Ischemic Attack, Transient/complications
Male
Middle Aged
Perfusion
Prospective Studies
Tomography, Emission-Computed, Single-Photon/*methods
LA - eng
N1 - Kamínek, Milan
Metelková, Iva
Budíková, Miroslava
Koranda, Pavel
Henzlova, Lenka
Havel, Martin
Sovová, Eliška
Kincl, Vladimír
Journal Article
Greece
Hell J Nucl Med. 2015 Jan-Apr;18(1):31-4.
PY - 2015
SN - 1790-5427 (Print)
1790-5427
SP - 31-4
ST - Diagnosis of high-risk patients with multivessel coronary artery disease by
combined cardiac gated SPET imaging and coronary calcium score
T2 - Hell J Nucl Med
TI - Diagnosis of high-risk patients with multivessel coronary artery disease by
combined cardiac gated SPET imaging and coronary calcium score
VL - 18
ID - 2796
ER -
TY - JOUR
AB - BACKGROUND: There are an increasing number of elderly patients with critical
aortic stenosis. This study was performed to evaluate the surgical outcome of
aortic valve surgery for elderly patients with aortic stenosis. METHODS: Eleven
patients aged over 75 years old (mean 79.7 +/- 4.4) underwent aortic valve
replacement with stented bioprosthesis from May 2001 to August 2004. All of the
patients had a history of congestive heart failure, syncope, or angina pectoris
with multiple medical problems including renal dysfunction, diabetes mellitus,
cerebral infarction, or coronary artery disease. The New York Heart Association
(NYHA) classification ranged II to IV (mean 2.8 +/- 0.7). Their logistic Euro score
ranged from 2.56 to 41.61 (mean 8.6 +/- 10.9). The concomitant procedures were
annular enlargement in 2 and coronary artery bypass grafting (CABG) in 3 patients.
RESULTS: All patients tolerated these procedures well and were discharged except 1
patient who died from arrhythmia on the postoperative day 14. Postoperative
echocardiogram after 3 months showed satisfactory decrease in peak left
ventricular-aortic pressure gradient as well as left ventricular mass regression.
All surviving patients are in NYHA class I. CONCLUSIONS: Aortic valve replacement
provided satisfactory results for elderly patients. Surgical treatment should be
considered even for the elderly patients with critical aortic stenosis under
meticulous perioperative management.
AD - Department of Second Surgery, University of Fukui Faculty of Medical
Sciences, Fukui, Japan.
AN - 16528988
AU - Kamisaka, T.
AU - Uesaka, T.
AU - Tanaka, K.
AU - Morioka, K.
AU - Ree, I.
AU - Yamada, N.
AU - Takamori, A.
AU - Handa, M.
AU - Tanabe, S.
AU - Ihaya, A.
AU - Sasaki, M.
DA - Mar
DP - NLM
ET - 2006/03/15
IS - 3
J2 - Kyobu geka. The Japanese journal of thoracic surgery
KW - Aged
Aged, 80 and over
Aortic Valve Stenosis/diagnostic imaging/*surgery
*Bioprosthesis
Echocardiography
Female
*Heart Valve Prosthesis Implantation
Humans
Male
LA - jpn
N1 - Kamisaka, T
Uesaka, T
Tanaka, K
Morioka, K
Ree, I
Yamada, N
Takamori, A
Handa, M
Tanabe, S
Ihaya, A
Sasaki, M
Journal Article
Japan
Kyobu Geka. 2006 Mar;59(3):181-6.
PY - 2006
SN - 0021-5252 (Print)
0021-5252
SP - 181-6
ST - [Surgical strategy for critical aoritc stenosis with small aortic annulus in
the elderly patients]
T2 - Kyobu Geka
TI - [Surgical strategy for critical aoritc stenosis with small aortic annulus in
the elderly patients]
VL - 59
ID - 3096
ER -
TY - JOUR
AB - To evaluate left atrial appendage (LAA) dysfunction using left atrial pulse-
wave tissue Doppler imaging (PW-TDI) in acute cerebral embolism (ACE) patients with
sinus rhythm (SR), transthoracic (TTE) and transesophageal echocardiograhy (TEE)
were performed in 60 consecutive patients with SR without obvious left ventricular
dysfunction within 2 weeks after ACE. Two groups were identified: LAA dysfunction
[LAA emptying peak flow velocity (LAA-eV) <0.55 m/s, n = 20, age 65 ± 10 years] and
without LAA dysfunction (LAA-eV ≥ 0.55 m/s, n = 40, age 64 ± 10 years) on TEE. Left
atrial wall motion velocity (WMV) was obtained from PW-TDI, with the sample volume
placed at the left atrial anterior wall adjacent to ascending aortic inferior wall
from the long axis view on TTE. WMVs showed triphasic waves: after the P wave (La')
during systole (Ls'), and during early diastole. La' and Ls' were significantly
lower in the group with versus without LAA dysfunction (4.9 ± 1.4 vs. 7.7 ± 1.8
cm/s, p < 0.0001; 5.3 ± 2.0 vs. 6.7 ± 1.9 cm/s, p < 0.001, respectively) and
prevalence of paroxysmal atrial fibrillation, left atrial volume index, and serum
levels of brain natriuretic peptide were significantly higher (60 vs. 15 %, p <
0.001; 32 ± 13 vs. 24 ± 13 ml/m(2), p < 0.05; 174 ± 279 vs. 48 ± 68 pg/ml, p <
0.01, respectively). La' was an independent predictor of LAA dysfunction (OR 0.380,
95 % CI 0.156-0.925, p < 0.05), and was significantly correlated with LAA-eV (r =
0.594, p < 0.0001) and LAA fractional area change (r = 0.682, p < 0.0001). The
optimal cut-off value for LAA-eV < 0.55 m/s was 5.5 cm/s (sensitivity 83 %,
specificity 88 %). La' is a useful and convenient strong predictor of LAA
dysfunction in ACE patients with SR.
AD - Department of Cardiology, Kitamurayama Municipal Hospital, 2-15-1 Onsen-
machi, Higashine, Yamagata, 999-3792, Japan, kz.kaneko@hosp-kitamurayama.jp.
AN - 24852338
AU - Kaneko, K.
AU - Otaki, Y.
AU - Kadowaki, S.
AU - Narumi, T.
AU - Saito, H.
AU - Kiribayashi, N.
AU - Omi, K.
AU - Sasaki, T.
AU - Niizeki, T.
AU - Sugawara, S.
AU - Kubota, I.
DA - Oct
DO - 10.1007/s10554-014-0455-3
DP - NLM
ET - 2014/05/24
IS - 7
KW - Aged
Atrial Appendage/*diagnostic imaging/*physiopathology
Atrial Fibrillation/blood/*complications/diagnostic imaging/physiopathology
Biomarkers/blood
*Echocardiography, Doppler, Pulsed
Female
Humans
Intracranial Embolism/blood/diagnostic imaging/*etiology/physiopathology
Logistic Models
Male
Middle Aged
Observer Variation
Odds Ratio
Pilot Projects
Risk Factors
LA - eng
N1 - 1875-8312
Kaneko, Kazuyoshi
Otaki, Yoichiro
Kadowaki, Shinpei
Narumi, Taro
Saito, Hiroki
Kiribayashi, Nobuyuki
Omi, Koki
Sasaki, Toshiki
Niizeki, Takeshi
Sugawara, Shigeo
Kubota, Isao
Journal Article
United States
Int J Cardiovasc Imaging. 2014 Oct;30(7):1245-54. doi: 10.1007/s10554-014-0455-3.
Epub 2014 May 23.
PY - 2014
SN - 1569-5794
SP - 1245-54
ST - Left atrial appendage dysfunction in acute cerebral embolism patients with
sinus rhythm: correlation with pulse wave tissue Doppler imaging
TI - Left atrial appendage dysfunction in acute cerebral embolism patients with
sinus rhythm: correlation with pulse wave tissue Doppler imaging
VL - 30
ID - 2952
ER -
TY - JOUR
AB - BACKGROUND: This study was conducted to investigate factors associated with
stroke in pa-tients with paroxysmal atrial fibrillation (PAF) beyond CHADS2 score
in terms of left ventricular (LV) diastolic function or left atrial (LA) function.
METHODS: One hundred and sixty-one patients with PAF and age less than 75 (mean age
61 ± 10; 69 male) who underwent transthoracic echocardiography were investigated.
Patients were divided into two groups according to the stroke status (group 1 - no
stroke vs. group 2 - presence of stroke). Baseline echocardiographic parameters and
LA segmental (4 segments: basal septal, lateral, inferior, and anterior) strain
rate (SR) during normal sinus rhythm were analyzed. RESULTS: CHAD score (except S2)
was similar between the two groups (0.6 ± 0.7 vs. 0.9 ± 0.7, p = 0.125). Patients
with stroke had slightly lower body mass index (24.5 ± 2.7 vs. 23.4 ± ± 2.4, p =
0.052). Echocardiographic parameters did not show any differences in both systolic
and diastolic functions between the two groups, however elevated E/E' ratio was
noted (9.5 ± ± 3.8 vs. 11.6 ± 3.9, p = 0.010) due to higher E velocity (63.5 ± 15.9
vs. 70.9 ± 16.0 cm/s, p = 0.046). In the analysis of LA SR, there are no
differences of SR among the 4 segments. However, standard deviations (SD) of time
to peak SR (SD of tA-SR) of the 4 segments were higher in patients with stroke
(10.9 ± 9.9 vs. 22.1 ± 18.1 ms, p = 0.009) which indicates dyssynchronous
contraction of LA. In multivariate analysis, SD of tA-SR (OR 1.074, CI 1.024-1.128,
p = 0.004) and elevated E/E' (OR 1.189, CI 1.006-1.406, p = 0.048) were
independently associated with stroke in patients with PAF. CONCLUSIONS: Elevated E
velocity, E/E' and SD of tA-SR were associated with occurrence of stroke in
patients with PAF even with similar CHAD scores. Increased SD of tA-SR and E/E'
were independently associated with stroke in patients with PAF. (.
AD - Cardiology Division, Kangnam Sacred Heart Hospital, Hallym University Medical
Center, Seoul, South Korea. homes78@naver.com.
AN - 27296157
AU - Kang, M. K.
AU - Han, C.
AU - Chun, K. J.
AU - Choi, J.
AU - Choi, S.
AU - Cho, J. R.
AU - Lee, N.
DO - 10.5603/CJ.a2016.0028
DP - NLM
ET - 2016/06/15
IS - 4
KW - Atrial Fibrillation/*complications/diagnosis/physiopathology
Echocardiography
Follow-Up Studies
Humans
Risk Factors
Time Factors
Ventricular Function, Left/*physiology
*left atrium
*paroxysmal atrial fibrillation
*strain rate
*stroke
LA - eng
N1 - 1897-5593
Kang, Min-Kyung
Han, Chaehoon
Chun, Kwang Jin
Choi, Jaehuk
Choi, Seonghoon
Cho, Jung-Rae
Lee, Namho
Journal Article
Observational Study
Poland
Cardiol J. 2016;23(4):429-36. doi: 10.5603/CJ.a2016.0028. Epub 2016 Jun 14.
PY - 2016
SN - 1898-018x
SP - 429-36
ST - Factors associated with stroke in patients with paroxysmal atrial
fibrillation beyond CHADS2 score
T2 - Cardiol J
TI - Factors associated with stroke in patients with paroxysmal atrial
fibrillation beyond CHADS2 score
VL - 23
ID - 2383
ER -
TY - JOUR
AB - Patients (n=263, age 49-64 years) with persistent nonvalvular atrial
fibrillation were subjected to controlled treatment aimed at restoration and
maintenance of sinus rhythm (n=134) or slowing of rate of ventricular contractions.
Efficacy of complementary use of combination of simvastatin with aspirin, warfarin
and aspirin for prevention of ischemic stroke was assessed in both of these
strategies. First strategy, supplemented with combination of simvastatin and
aspirin prevented ischemic stroke and lethal outcome most successfully, while the
use of warfarin was unexpectedly associated with comparative elevation of risk of
ischemic stroke. It is impossible to exclude that long term administration of
warfarin in strategy of sinus rhythm maintenance attenuated advantages of normal
rhythm in relation of lowering of stroke risk in AFFIRM study and other similar
works. Contrary to known cardio-embolic mechanism of cerebral embolism in permanent
atrial fibrillation main aim of the treatment in successful sinus rhythm
maintenance may become prevention of arterio-arterial emboli.
AN - 17426677
AU - Kanorskiĭ, S. G.
AU - Shevelev, V. I.
AU - Zafiraki, V. K.
AU - Zingilevskiĭ, K. B.
DP - NLM
ET - 2007/04/12
IS - 1
J2 - Kardiologiia
Brain Ischemia/etiology/*prevention & control
Echocardiography
Electrocardiography
Female
Follow-Up Studies
Humans
Male
Middle Aged
Myocardial Contraction/drug effects
Simvastatin/*therapeutic use
Sinoatrial Node/drug effects/*physiopathology
Treatment Outcome
LA - rus
N1 - Kanorskiĭ, S G
Shevelev, V I
Zafiraki, V K
Zingilevskiĭ, K B
English Abstract
Journal Article
Russia (Federation)
Kardiologiia. 2007;47(1):26-30.
PY - 2007
SN - 0022-9040 (Print)
0022-9040
SP - 26-30
ST - [Prevention of ischemic stroke in middle aged patients with atrial
fibrillation. Effect of sinus rhythm maintenance, aspirin, warfarin, and
simvastatin]
T2 - Kardiologiia
TI - [Prevention of ischemic stroke in middle aged patients with atrial
fibrillation. Effect of sinus rhythm maintenance, aspirin, warfarin, and
simvastatin]
VL - 47
ID - 2963
ER -
TY - JOUR
AB - Implantable cardioverter defibrillator (ICD) implantation is a common
approach in patients at high risk of sudden cardiac death. Verification of
defibrillation efficacy by defibrillation threshold (DFT) testing during ICD
implantation is the current standard. Traditionally, a safety margin of at least 10
J between the maximum output of the pulse generator and the energy needed for
defibrillation has been used because early studies indicate that lower safety
margins were associated with high rates of failed defibrillation and sudden cardiac
death. Improvements in ICD and lead technology result in marked reductions in
defibrillation thresholds and more stable thresholds long term. Despite these
improvements, some patients still require system modification during implantation
to obtain an adequate safety margin. During DFT testing multiple induction of
ventricular fibrillation cause brief transient episodes of cerebral ischemia. These
repeated short episodes of circulatory arrest with global cerebral ischemia have
been associated with changes in cerebral oxygen uptake and cerebral electrical
activity. In addition, minor neurologic injury can occur after ICD implantation and
defibrillation testing. This finding needs to be examined in further research.
AD - Department of Cardiology, University of Ankara Medical Faculty, Ankara,
Turkey. karaoguz@ medicine.ankara.edu.tr
AN - 17584679
AU - Karaoğuz, R.
DA - Jul
DP - NLM
ET - 2007/08/01
J2 - Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology
KW - Brain Ischemia/etiology
*Cardiac Pacing, Artificial/adverse effects
*Defibrillators, Implantable/adverse effects
Equipment Safety
Humans
Sensory Thresholds
Ventricular Fibrillation/*prevention & control
LA - eng
N1 - Karaoğuz, Remzi
Journal Article
Review
Turkey
Anadolu Kardiyol Derg. 2007 Jul;7 Suppl 1:47-9.
PY - 2007
SN - 1302-8723 (Print)
1302-8723
SP - 47-9
ST - Defibrillation threshold testing and neurologic outcome
T2 - Anadolu Kardiyol Derg
TI - Defibrillation threshold testing and neurologic outcome
VL - 7 Suppl 1
ID - 2946
ER -
TY - JOUR
AB - During implantable cardioverter-defibrillator (ICD) implantation, ventricular
defibrillation testing (DFT) is considered a standard procedure. This procedure
often requires multiple ventricular fibrillation (VF) inductions. These repeated
short episodes of circulatory arrest with global cerebral ischemia may cause
neurological damage. In the present study, patients undergoing initial ICD
implantation and limited induction of VF for defibrillation safety margin testing
were evaluated for pre- and postoperative cognitive and neurologic functions. In
addition, the serum neuron specific enolase (NSE) level, which is a biochemical
marker of cerebral injury, was evaluated. The study was performed on 16 patients
undergoing initial elective transvenous insertion of an ICD. A neurologic
examination and cognitive assessment tests were performed 24 to 48 hours before and
after ICD. NSE was determined before (NSE 1) and at the end of the surgery (NSE 2),
as well as 2 hours (NSE 3), 24 hours (NSE 4), and 48 hours (NSE 5) after
implantation. A total of 29 internal shocks (average, 1.8 +/- 0.4) with energy
ranging from 14 to 41 J (mean, 20 +/- 5; median, 20 J ) were delivered in the ICD
group patients. In one patient, 3 external (50, 200 and 360 J) shocks were required
for fast VT induced during ICD lead positioning. The mean duration of VF was 10 +/-
4 seconds and the mean cumulative time in VF was 16 +/- 5 seconds. The mean
recovery time between VFs was 5.3 +/- 0.6 minutes. NSE levels were not different
from the baseline at any time point in the patients of the group that completed the
48-hour observation period (P > 0.05). The patients did not report any new
neurological symptoms after ICD implantation, and repeat examination after the
procedure showed no abnormal findings other than those detected in the previous
one. There were no statistically significant differences between the preoperative
and postoperative scores obtained in the cognitive assessment. Single or two VF
inductions and the brief arrest of cerebral circulation during ICD implantation are
not associated with permanent neurological injury. However, further studies are
needed to confirm this finding.
AD - Department of Cardiology University of Ankara Medical Faculty, Ankara,
Turkey.
AN - 18971567
AU - Karaoguz, R.
AU - Altln, T.
AU - Atbasoglu, E. C.
AU - Isikay, C.
AU - Güraslan, B.
AU - Akyürek, O.
AU - Beton, O.
AU - Vurgun, K.
AU - Yüceman, N.
AU - Soylu, K.
AU - Güldal, M.
DA - Sep
DO - 10.1536/ihj.49.553
DP - NLM
ET - 2008/10/31
IS - 5
J2 - International heart journal
KW - Aged
Cognition/*physiology
Electric Countershock/*adverse effects
*Equipment Safety
Female
Follow-Up Studies
Humans
Male
Middle Aged
Nervous System/physiopathology
Phosphopyruvate Hydratase/blood
Treatment Outcome
Ventricular Fibrillation/enzymology/*etiology/*psychology
LA - eng
N1 - Karaoguz, Remzi
Altln, Timuein
Atbasoglu, E Cem
Isikay, Canan
Güraslan, Bahar
Akyürek, Omer
Beton, Osman
Vurgun, Kutay
Yüceman, Nezih
Soylu, Kazim
Güldal, Muharrem
Journal Article
Japan
Int Heart J. 2008 Sep;49(5):553-63. doi: 10.1536/ihj.49.553.
PY - 2008
SN - 1349-2365 (Print)
1349-2365
SP - 553-63
ST - Defibrillation testing and early neurologic outcome
T2 - Int Heart J
TI - Defibrillation testing and early neurologic outcome
VL - 49
ID - 2846
ER -
TY - JOUR
AB - We reported successful repair of tetoralogy of Fallot of a male case aged 59
years old. There was no palliative operation prior to this correction. The
preoperative clinical features were as follows: dyspnea on effort and at rest,
cyanosis and clubbing, multiple cerebral thrombosis without symptoms. Polycytemia
was remarkable at Hb 23.3 g/dl and Ht 73.8%. PaO2 was 39.2 mmHg and hypoxemia was
recognized. CTR was 59% and pulmonary vascular shadows were decreased but bilateral
pulmonary arteries were well developed. Cardiac catheterization showed that high RV
systolic pressure equal to that of LV and severe RV outflow obstruction. Pulmonary
artery was well developed (the diameter ratio of PA and aorta: 0.84). Collateral
arteries to the pulmonary vascular system were not significant by aortography. The
surgical procedures were performed under conventional method. Pulmonary valvular
stenosis was released by comissurotomy and RV outflow tract obstruction was also
released through minimal right ventriculotomy. The conus branch of coronary artery
crossed the outflow tract, so that we preserved this artery for preventing right
ventricular failure post-operatively. There was no need to use trans-annular patch
for reconstruction of the outflow tract. In post operative course, only a low
dosage of catecholamin was required but no other special treatment was needed.
Ventricular and supraventricular arrhythmia had appeared in short period but after
administration of anti arrhythmic drugs, heart rhythm was converted to sinus rhythm
easily. Pathological findings of RV muscle which resected at the operation showed
marked fibrous degeneration and irregularity of cells, and it suggested that sever
hypoxia and high pressure for long time affected the ventricular muscle. We
concluded that even older patients of tetralogy of Fallot were corrected safely and
were able to get good quality of life after operation.
AD - Department of Cardiology, Shirakawa Hospital, Japan.
AN - 8992045
AU - Karube, M.
AU - Utsunomiya, H.
AU - Iida, T.
AU - Kenjo, M.
AU - Iedokoro, Y.
AU - Hioki, M.
AU - Tanaka, S.
DA - May
DP - NLM
ET - 1996/05/01
IS - 5
KW - Age of Onset
Echocardiography
Humans
Male
Middle Aged
Tetralogy of Fallot/diagnostic imaging/pathology/*surgery
LA - jpn
N1 - Karube, M
Utsunomiya, H
Iida, T
Kenjo, M
Iedokoro, Y
Hioki, M
Tanaka, S
Case Reports
Journal Article
Japan
Kyobu Geka. 1996 May;49(5):395-9.
PY - 1996
SN - 0021-5252 (Print)
0021-5252
SP - 395-9
ST - [Total repair of tetoralogy of Fallot in an adult: report of a case without
prior treatment at 59 years of age]
T2 - Kyobu Geka
TI - [Total repair of tetoralogy of Fallot in an adult: report of a case without
prior treatment at 59 years of age]
VL - 49
ID - 3090
ER -
TY - JOUR
AB - OBJECTIVES: This study investigated the differences in presentation,
complications, and outcome of young patients with acute myocardial infarction
compared to other patients. METHODS: Our series of 379 consecutive patients with
acute myocardial infarction, who were admitted within 12 hr of onset and
successfully reperfused by primary percutaneous coronary intervention, included 28
(7.4%) young patients (< 50 years). RESULTS: There were significantly more male
patients, current smokers, and hyperlipidemia in the young group than in the other
patients (p < 0.01). The levels of acute phase brain natriuretic peptide (BNP) and
atrial natriuretic peptide (ANP) were significantly lower (BNP: 128 +/- 103 vs 379
+/- 470 pg/ml, p = 0.009, ANP: 17 +/- 11 vs 66 +/- 81 pg/ml, p = 0.004) and peak
creatine kinase value was significantly higher (3,824 +/- 3,459 vs 2,413 +/- 2,023
IU/l, p = 0.009) in the young group than in the other patients. The increase
(chronic phase-acute phase) of left ventricular ejection fraction was significantly
better in the young group (8 +/- 9% vs 4 +/- 10%, p < 0.05). There were
significantly fewer patients with ventricular arrhythmia in the young group than in
the other patients (10.7% vs 33.0%, p = 0.04). The cardiac mortality rate in the
first 6 months was only 3.6% in the young group. CONCLUSIONS: Young patients with
acute myocardial infarction, in spite of higher peak creatine kinase value, seemed
to have excellent prognosis, with lower BNP and good recovery of left ventricular
ejection fraction.
AD - Department of Cardiology, Nagasaki Kouseikai Hospital, Akahaku 2-5-5-1615,
Nagasaki, Nagasaki 852-8156. snowman-kt@syd.odn.ne.jp
AN - 16886494
AU - Katayama, T.
AU - Iwasaki, Y.
AU - Yamamoto, T.
AU - Yoshioka, M.
AU - Nakashima, H.
AU - Suzuki, S.
AU - Yano, K.
DA - Jul
DP - NLM
ET - 2006/08/05
IS - 1
KW - Adult
*Angioplasty, Balloon, Coronary
Creatine Kinase, MB Form/metabolism
Female
Humans
Hyperlipidemias/physiopathology
Male
Middle Aged
Myocardial Infarction/physiopathology/*therapy
Natriuretic Peptide, Brain/metabolism
Smoking/physiopathology
Treatment Outcome
LA - jpn
N1 - Katayama, Toshiro
Iwasaki, Yoshihiro
Yamamoto, Tadashi
Yoshioka, Masato
Nakashima, Hiroshi
Suzuki, Shin
Yano, Katsusuke
English Abstract
Journal Article
Netherlands
J Cardiol. 2006 Jul;48(1):1-7.
PY - 2006
SN - 0914-5087 (Print)
0914-5087
SP - 1-7
ST - [Clinical manifestations and outcome of acute myocardial infarction in young
adults treated with primary coronary angioplasty]
T2 - J Cardiol
TI - [Clinical manifestations and outcome of acute myocardial infarction in young
adults treated with primary coronary angioplasty]
VL - 48
ID - 3105
ER -
TY - JOUR
AB - BACKGROUND: The clinical characteristics of ischemic stroke in patients with
a pacemaker (PM) are not well understood. METHODS: Forty-six ischemic stroke
patients with a PM were investigated retrospectively, and the impact of different
pacing modes was compared. RESULTS: The patients were divided into a physiological
pacing group (n = 22) and a ventricular pacing group (n = 24). The prevalence of
atrial fibrillation (AF) was significantly higher in the ventricular pacing group
(36% versus 75%; P = .008). The mean left atrial dimension was relatively large in
the ventricular pacing group than in the physiological pacing group (44.5 ± 6.7 mm
versus 39.1 ± 8.5 mm, respectively; P = .071). Twenty-four percent of the patients
were receiving anticoagulants, whereas 41% of the patients were receiving
antiplatelet drugs. Cardioembolism was the most common stroke subtype in both
groups. Although there was no statistically significant difference, neurological
severity on admission was higher in the ventricular pacing group than in the
physiological pacing group (P = .061). Functional outcomes, excluding patients with
transient ischemic attack or prior stroke, significantly declined in the
ventricular pacing group compared with the physiological pacing group (P = .044).
CONCLUSIONS: The avoidance of the ventricular pacing mode may result in improved
clinical outcomes. In patients without persistent AF, it may be important to select
physiological pacing instead of ventricular pacing to decrease potential stroke
severity.
AD - Department of Neurology and Cerebrovascular Medicine, Saitama Medical
University International Medical Center, Saitama, Japan. Electronic address:
yujik@saitama-med.ac.jp.
Department of Neurology and Cerebrovascular Medicine, Saitama Medical University
International Medical Center, Saitama, Japan.
Department of Cardiology, Saitama Medical University International Medical Center,
Saitama, Japan.
AN - 28709743
AU - Kato, Y.
AU - Hayashi, T.
AU - Kato, R.
AU - Tanahashi, N.
AU - Takao, M.
DA - Sep
DO - 10.1016/j.jstrokecerebrovasdis.2017.06.020
DP - NLM
ET - 2017/07/16
IS - 9
J2 - Journal of stroke and cerebrovascular diseases : the official journal of
National Stroke Association
KW - Aged
Aged, 80 and over
Atrial Fibrillation/diagnosis/drug therapy/*etiology/physiopathology
Atrioventricular Block/diagnosis/physiopathology/*therapy
Brain Ischemia/diagnosis/*etiology/physiopathology
Cardiac Pacing, Artificial/*adverse effects/*methods
Disability Evaluation
Female
Heart Ventricles/*physiopathology
Humans
Male
Middle Aged
Risk Factors
Sick Sinus Syndrome/diagnosis/physiopathology/*therapy
Stroke/diagnosis/*etiology/physiopathology
*Ventricular Function
Ischemic stroke
atrial fibrillation
pacemaker mode
physiological pacing
ventricular pacing
LA - eng
N1 - 1532-8511
Kato, Yuji
Hayashi, Takeshi
Kato, Ritsushi
Tanahashi, Norio
Takao, Masaki
Comparative Study
Journal Article
United States
J Stroke Cerebrovasc Dis. 2017 Sep;26(9):1948-1952. doi:
10.1016/j.jstrokecerebrovasdis.2017.06.020. Epub 2017 Jul 11.
PY - 2017
SN - 1052-3057
SP - 1948-1952
ST - Ischemic Stroke with Cardiac Pacemaker Implantation: Comparison of
Physiological and Ventricular Pacing Modes
T2 - J Stroke Cerebrovasc Dis
TI - Ischemic Stroke with Cardiac Pacemaker Implantation: Comparison of
Physiological and Ventricular Pacing Modes
VL - 26
ID - 2314
ER -
TY - JOUR
AB - Based on the results of the Cardiac Arrhythmia Suppression Trial (CAST),
strategies for the treatment of tachyarrhythmias have changed rapidly. The Japanese
Antiarrhythmics Long-Term (JALT) study was planned to investigate the present
methods for choosing antiarrhythmic drugs, and the effects on long-term prognosis
in patients with tachyarrhythmias in Japan. Following a 6-month preliminary study
(JALT-1), there was a multicenter nonrandomized prospective study (JALT-2), with a
2-year follow-up, of patients with paroxysmal atrial fibrillation (PAF), sustained
ventricular tachycardia (SVT) and nonsustained VT (NSVT). Four hundred fifty-five
patients were registered, and 361 of them (79%) were analyzed. Cerebral infarction
occurred in 10 of 193 patients (5.2%) with PAF. Transition to chronic AF was
observed in 21 patients (10.9%), but in none of the patients receiving Ca
antagonist therapy. Twenty-five patients died: 5 deaths were arrhythmic, 10 were
because of pump failure, and 9 were noncardiac. The most significant difference in
drug selection between JALT-1 and JALT-2 was the increase in the use of slow
kinetic Na channel blockers for PAF and the decrease in the use of the same agents
for VT in the JALT-2 study. A marked change of therapeutic strategy occurred in
JALT-2 compared with JALT-1. Most patients with a poor prognosis had underlying
heart diseases and heart failure, but the per annum rate of death by arrhythmia and
pump failure in JALT-2 was less than that in JALT-1.
AD - First Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
AN - 11316122
AU - Katoh, T.
AU - Iinuma, H.
AU - Inoue, H.
AU - Ohe, T.
AU - Ogawa, S.
AU - Kasanuki, H.
AU - Tanabe, T.
AU - Hayakawa, H.
DA - Apr
DO - 10.1253/jcj.65.275
DP - NLM
ET - 2001/04/24
IS - 4
J2 - Japanese circulation journal
KW - Adult
Aged
Anti-Arrhythmia Agents/classification/*therapeutic use
Atrial Fibrillation/drug therapy/epidemiology
Cause of Death
Cerebral Infarction/epidemiology/etiology
Disease Progression
Drug Utilization/statistics & numerical data/trends
Female
Follow-Up Studies
Heart Failure/mortality
Humans
Japan/epidemiology
Male
Middle Aged
Prognosis
Prospective Studies
Recurrence
Risk Factors
Tachycardia/complications/*drug therapy/epidemiology
Tachycardia, Ventricular/drug therapy/epidemiology
Treatment Outcome
LA - eng
N1 - Katoh, T
Iinuma, H
Inoue, H
Ohe, T
Ogawa, S
Kasanuki, H
Tanabe, T
Hayakawa, H
Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Japan
Jpn Circ J. 2001 Apr;65(4):275-8. doi: 10.1253/jcj.65.275.
PY - 2001
SN - 0047-1828 (Print)
0047-1828
SP - 275-8
ST - Multicenter prospective nonrandomized study of long-term antiarrhythmic drug
therapy in patients with tachyarrhythmias: Japanese Antiarrhythmics Long-Term
Study-2 (JALT-2 Study)
T2 - Jpn Circ J
TI - Multicenter prospective nonrandomized study of long-term antiarrhythmic drug
therapy in patients with tachyarrhythmias: Japanese Antiarrhythmics Long-Term
Study-2 (JALT-2 Study)
VL - 65
ID - 2651
ER -
TY - JOUR
AB - PURPOSE: To describe the anesthetic management and clinical course of a
patient with peripartum cardiomyopathy. We highlight the frequent occurrence of
thromboembolic morbidity in this group of parturients, emphasizing the need for
early consideration of prophylactic anticoagulation. CLINICAL FEATURES: A 38-yr-
old, diabetic, obese parturient was admitted with pulmonary edema and severe
orthopnea at 31 weeks gestation. The respiratory rate was 44 breaths x min(-1),
blood pressure 110/70 mmHg, pulse 120 beats x min(-1) and rales were heard in both
lung fields. The diagnosis of peripartum cardiomyopathy was made based on sinus
tachycardia with no evidence of ischemia on the electrocardiogram, and global left
ventricular hypokinesis with an ejection fraction of 40-45% noted on transthoracic
echocardiography. Cesarean delivery was planned to improve maternal respiratory
status and hemodynamics. General anesthesia with invasive monitoring was planned,
and surgery and anesthesia proceeded uneventfully. Less than 24 hr postoperatively,
she sustained a thrombotic cerebral infarct leaving her hemiparetic and dysarthric.
Subsequent investigations revealed a thrombophilic state due to elevated
anticardiolipin antibody. CONCLUSION: General anesthesia is an acceptable option in
parturients with heart failure secondary to cardiomyopathy. Thromboembolic
complications are common, and early consideration should be given to prophylactic
anticoagulation.
AD - Department of Anesthesia, McGill University Health Centre Royal Victoria
Hospital Montreal Quebec Canada. iankaufman@hotmail.com
AN - 12560308
AU - Kaufman, I.
AU - Bondy, R.
AU - Benjamin, A.
DA - Feb
DO - 10.1007/bf03017850
DP - NLM
ET - 2003/02/01
IS - 2
J2 - Canadian journal of anaesthesia = Journal canadien d'anesthesie
KW - Adult
*Anesthesia
Cardiomyopathies/diagnosis/etiology/*therapy
*Diabetes Complications
Dyspnea/complications
Female
Heart Transplantation/physiology
Humans
Morphine/therapeutic use
Obesity/*complications
Obstetric Labor Complications/*therapy
Pain, Postoperative/drug therapy
Pregnancy
Thromboembolism/diagnosis/etiology/*therapy
LA - eng
N1 - Kaufman, Ian
Bondy, Richard
Benjamin, Alice
Case Reports
Journal Article
United States
Can J Anaesth. 2003 Feb;50(2):161-5. doi: 10.1007/BF03017850.
PY - 2003
SN - 0832-610X (Print)
0832-610x
SP - 161-5
ST - Peripartum cardiomyopathy and thromboembolism; anesthetic management and
clinical course of an obese, diabetic patient
T2 - Can J Anaesth
TI - Peripartum cardiomyopathy and thromboembolism; anesthetic management and
clinical course of an obese, diabetic patient
VL - 50
ID - 3046
ER -
TY - JOUR
AB - One challenge encountered during catheter ablation of postinfarction
ventricular tachycardia (VT) is the inducibility of multiple VT morphologies
associated with variable hemodynamic instability. The clinical usefulness and
safety of a three-dimensional electroanatomical mapping in guiding radiofrequency
(RF) catheter ablation of VT, used in parallel with a multichannel recording
system, was studied in 28 men (mean age = 63.8 +/- 10.6 years, mean left
ventricular ejection fraction = 28% +/- 9%). Three-dimensional voltage maps of the
left ventricle were obtained in sinus rhythm with annotation of areas of
fractionated or late potentials, zones of slow conduction and/or dense scar with no
pacing capture at 10 mA. RF lesions were created either in sinus rhythm or during
hemodynamically stable VT within reconstructed critical zones of the circuit. A
total of 82 VTs were induced (mean = 2.9 +/- 1.0/patient). Hemodynamically unstable
clinical VTs were induced in 5 patients, and clinical or nonclinical unstable VT in
14. Clinical VT was rendered noninducible in 24/28 (85.7%) patients, and
monomorphic VT was eliminated in 16/28 (57.1%) patients. The mean procedural time
was 258 +/- 82 minutes, and fluoroscopic exposure 13.5 +/- 8.8 minutes. During a
mean follow-up period of 10.6 +/- 6.4 months, catheter ablation was repeated in 6
patients for VT recurrences. No significant complications occurred except for a
transient cerebral ischemic attack in one patient. In conclusion, electroanatomical
mapping assisted the successful and safe catheter ablation of both mappable and
nonmappable VTs in a significant proportion of patients after myocardial
infarction.
AD - Department of Cardiology, Institute for Clinical and Experimental Medicine,
Vídenská 1958/9, 140 21 Prague 4, Czech Republic. josef.kautzner@medicon.cz
AN - 12687842
AU - Kautzner, J.
AU - Cihák, R.
AU - Peichl, P.
AU - Vancura, V.
AU - Bytesník, J.
DA - Jan
DO - 10.1046/j.1460-9592.2003.00046.x
DP - NLM
ET - 2003/04/12
IS - 1p2
KW - Catheter Ablation/*methods
Humans
Imaging, Three-Dimensional
Male
Middle Aged
Recurrence
Reoperation
Tachycardia, Ventricular/etiology/*surgery
LA - eng
N1 - Kautzner, Josef
Cihák, Robert
Peichl, Petr
Vancura, Vlastimil
Bytesník, Jan
Journal Article
United States
Pacing Clin Electrophysiol. 2003 Jan;26(1P2):342-7. doi: 10.1046/j.1460-
9592.2003.00046.x.
PY - 2003
SN - 0147-8389 (Print)
0147-8389
SP - 342-7
ST - Catheter ablation of ventricular tachycardia following myocardial infarction
using three-dimensional electroanatomical mapping
TI - Catheter ablation of ventricular tachycardia following myocardial infarction
using three-dimensional electroanatomical mapping
VL - 26
ID - 2845
ER -
TY - JOUR
AB - OBJECTIVES: Limited data are available regarding Holter monitoring for
cardiovascular events except for ventricular tachycardia as a risk marker for
sudden death in hypertrophic cardiomyopathy (HCM). We aimed to examine Holter
findings in relation to the long-term prognosis in patients with HCM. METHODS:
Ambulatory Holter monitoring was performed in 106 HCM patients with sinus rhythm.
All were prospectively followed for the composite endpoint of sudden death,
cardiovascular death, and hospitalization for heart failure or stroke associated
with atrial fibrillation. RESULTS: Cardiovascular events occurred in 19 patients
during a mean follow-up of 10.1 years. Neither arrhythmia information nor autonomic
information as assessed by heart rate variability and turbulence significantly
differed between HCM patients with and without cardiovascular events. Average heart
rates were lower in HCM patients with cardiovascular events (64.7 ± 11.2 beats/min)
than in those without (73.7 ± 10.2 beats/min, p = 0.001). Multivariate Cox
proportional hazards regression analysis after adjustment for baseline
characteristics showed that lower average heart rate remained an independent
predictor of cardiovascular events (HR: 0.47 per 10 increase; 95% CI: 0.25-0.87; p
= 0.016). CONCLUSION: Average heart rate on Holter monitoring predicted long-term
prognosis in our cohort. Further multicenter studies are needed to confirm our
results.
AD - Department of Cardiology, Matsushita Memorial Hospital, Osaka, Japan. js-
k@wf6.so-net.ne.jp
AN - 22722267
AU - Kawasaki, T.
AU - Sakai, C.
AU - Harimoto, K.
AU - Yamano, M.
AU - Miki, S.
AU - Kamitani, T.
AU - Sugihara, H.
DO - 10.1159/000338156
DP - NLM
ET - 2012/06/23
IS - 1
J2 - Cardiology
KW - Adult
Aged
Aged, 80 and over
Arrhythmias, Cardiac/*diagnosis/etiology
Cardiomyopathy, Hypertrophic/*complications
Circadian Rhythm
Female
Humans
Long-Term Care
Male
Middle Aged
Prognosis
Risk Assessment
Young Adult
LA - eng
N1 - 1421-9751
Kawasaki, Tatsuya
Sakai, Chieko
Harimoto, Kuniyasu
Yamano, Michiyo
Miki, Shigeyuki
Kamitani, Tadaaki
Sugihara, Hiroki
Journal Article
Switzerland
Cardiology. 2012;122(1):44-54. doi: 10.1159/000338156. Epub 2012 Jun 19.
PY - 2012
SN - 0008-6312
SP - 44-54
ST - Holter monitoring and long-term prognosis in hypertrophic cardiomyopathy
T2 - Cardiology
TI - Holter monitoring and long-term prognosis in hypertrophic cardiomyopathy
VL - 122
ID - 2662
ER -
TY - JOUR
AB - Although amiodarone is effective in the treatment of ventricular arrhythmias,
it is associated with serious toxic effects. In addition, the prognosis of patients
with malignant ventricular arrhythmias and coronary artery disease treated with
amiodarone remains poor. The survival of 54 consecutive patients with
angiographically documented coronary artery disease and symptomatic ventricular
tachycardia or ventricular fibrillation treated with amiodarone was compared with
that of 5,125 medically treated patients with coronary artery disease. The
amiodarone group was older, with worse left ventricular function and more
peripheral and cerebrovascular disease. The 1 year survival probability was 0.73
for the amiodarone group and 0.94 for the control coronary artery disease group. At
2 years of follow-up, the survival probabilities were 0.60 and 0.90 for the
amiodarone and the control group, respectively. When the survival curves were
adjusted for group differences in baseline prognostic characteristics (integrated
as a previously published hazard score), there was no difference in the prognosis
of the two groups. These findings suggest that treatment with amiodarone of
malignant ventricular arrhythmias associated with coronary artery disease maintains
patients on an underlying survival curve determined by the degree of myocardial
dysfunction, clinical characteristics and coronary anatomy, and that amiodarone
does not have a deleterious effect on survival.
AN - 3558986
AU - Kay, G. N.
AU - Pryor, D. B.
AU - Lee, K. L.
AU - Harrell, F. E., Jr.
AU - Pressley, J. C.
AU - Gilbert, M. R.
AU - German, L. D.
DA - Apr
DO - 10.1016/s0735-1097(87)80245-0
DP - NLM
ET - 1987/04/01
IS - 4
KW - Aged
Amiodarone/adverse effects/*therapeutic use
Coronary Disease/complications/*drug therapy/mortality
Female
Heart Ventricles
Humans
Male
Middle Aged
Prognosis
Tachycardia/complications/*drug therapy
LA - eng
N1 - Kay, G N
Pryor, D B
Lee, K L
Harrell, F E Jr
Pressley, J C
Gilbert, M R
German, L D
HL-17670/HL/NHLBI NIH HHS/United States
HS-04873/HS/AHRQ HHS/United States
LM-07003/LM/NLM NIH HHS/United States
etc.
Journal Article
United States
J Am Coll Cardiol. 1987 Apr;9(4):877-81. doi: 10.1016/s0735-1097(87)80245-0.
PY - 1987
SN - 0735-1097 (Print)
0735-1097
SP - 877-81
ST - Comparison of survival of amiodarone-treated patients with coronary artery
disease and malignant ventricular arrhythmias with that of a control group with
TI - Comparison of survival of amiodarone-treated patients with coronary artery
disease and malignant ventricular arrhythmias with that of a control group with
VL - 9
ID - 2949
ER -
TY - JOUR
AB - Mild induced hypothermia improves neurological outcome and reduces mortality
among initially comatose survivors of out-of-hospital cardiac arrest. Similar
pathological processes occur in the heart and the brain, namely ischaemia followed
by reperfusion injury. Animal data indicate that mild induced hypothermia results
in improved myocardial salvage, reduced infarct size, reduced left ventricular
remodelling and better long-term left ventricular function. Several small human
studies suggest that infarct size may be reduced by mild induced hypothermia,
although this has not reached significance in any human study to date. There are
variable reports of harm to the myocardium caused by mild induced hypothermia,
including reduced myocardial contractility and cardiac output, electrocardiographic
changes and arrhythmias, especially bradycardia. These harmful effects are
reversible with rewarming.
AD - Department of Anaesthesia and Intensive Care Medicine, Frenchay Hospital,
Bristol, UK. fiona.kelly@doctors.org.uk
AN - 20151956
AU - Kelly, F. E.
AU - Nolan, J. P.
DA - May
DO - 10.1111/j.1365-2044.2009.06237.x
DP - NLM
ET - 2010/02/16
IS - 5
J2 - Anaesthesia
KW - Animals
Heart Arrest/therapy
Humans
*Hypothermia, Induced/adverse effects
Myocardial Infarction/pathology/*prevention & control
LA - eng
N1 - 1365-2044
Kelly, Fiona E
Nolan, J P
Journal Article
Review
Systematic Review
England
Anaesthesia. 2010 May;65(5):505-15. doi: 10.1111/j.1365-2044.2009.06237.x. Epub
2010 Feb 11.
PY - 2010
SN - 0003-2409
SP - 505-15
ST - The effects of mild induced hypothermia on the myocardium: a systematic
review
T2 - Anaesthesia
TI - The effects of mild induced hypothermia on the myocardium: a systematic
review
VL - 65
ID - 2868
ER -
TY - JOUR
AB - BACKGROUND AND PURPOSE: Familial transmission of stroke and myocardial
infarction (MI) is partially mediated by transmission of cerebrovascular and
cardiovascular risk factors. We examined relationships between family risk of
stroke and MI with risk factors for these phenotypes. METHODS: A cross-sectional
association between the stratified log-rank family score for stroke and MI with
prevalent risk factors was assessed in the REasons for Geographic And Racial
Differences in Stroke (REGARDS) cohort. RESULTS: Individuals in the fourth quartile
of stratified log-rank family scores for stroke were more likely to have prevalent
risk factors including hypertension (OR, 1.43; 95% CI, 1.30-1.58), left ventricular
hypertrophy (OR, 1.42; 95% CI, 1.16-1.42), diabetes (OR, 1.26; 95% CI, 1.12-1.43),
and atrial fibrillation (OR, 1.23; 95% CI, 1.03-1.45) compared with individuals in
the first quartile. Likewise, individuals in the fourth quartile of stratified log-
rank family scores for MI were more likely to have prevalent risk factors including
hypertension (OR, 1.57; 95% CI, 1.27-1.94) and diabetes (OR, 1.29; 95% CI, 1.12-
1.43) than the first quartile. In contrast to stroke, the family risk score for MI
was associated with dyslipidemia (OR, 1.38; 95% CI, 1.23-1.55) and
overweight/obesity (OR, 1.22; 95% CI, 1.10-1.37). CONCLUSIONS: Family risk of
stroke and MI is strongly associated with the majority of risk factors associated
with each disease. Family history and genetic studies separating nonspecific
contributions of intermediate phenotypes from specific contributions to the disease
phenotype may lead to a more thorough understanding of transmission for these
complex disorders.
AD - Department of Biostatistics, School of Public Health, 1665 University
Boulevard, University of Alabama at Birmingham, Birmingham, AL 35294-0022, USA.
AN - 22328552
AU - Kennedy, R. E.
AU - Howard, G.
AU - Go, R. C.
AU - Rothwell, P. M.
AU - Tiwari, H. K.
AU - Feng, R.
AU - McClure, L. A.
AU - Prineas, R. J.
AU - Banerjee, A.
AU - Arnett, D. K.
C2 - PMC3805250
C6 - NIHMS501140
DA - Apr
DO - 10.1161/strokeaha.111.645044
DP - NLM
ET - 2012/02/14
IS - 4
J2 - Stroke
KW - Aged
Atrial Fibrillation/complications/epidemiology/genetics
Cohort Studies
Diabetes Complications/epidemiology/genetics
*Family
Female
Humans
Hypertension/complications/epidemiology/genetics
Hypertrophy, Left Ventricular/complications/epidemiology/genetics
Male
Middle Aged
Myocardial Infarction/complications/*epidemiology/*genetics
Prevalence
Risk Factors
Stroke/complications/*epidemiology/*genetics
LA - eng
N1 - 1524-4628
Kennedy, Richard E
Howard, George
Go, Rodney C
Rothwell, Peter M
Tiwari, Hemant K
Feng, Rui
McClure, Leslie A
Prineas, Ronald J
Banerjee, Amitava
Arnett, Donna K
095626/Wellcome Trust/United Kingdom
T32HL072757/HL/NHLBI NIH HHS/United States
Clinical Trial
Comparative Study
Journal Article
Multicenter Study
PY - 2012
SN - 0039-2499 (Print)
0039-2499
SP - 974-9
ST - Association between family risk of stroke and myocardial infarction with
prevalent risk factors and coexisting diseases
T2 - Stroke
TI - Association between family risk of stroke and myocardial infarction with
prevalent risk factors and coexisting diseases
VL - 43
ID - 2382
ER -
TY - JOUR
AB - BACKGROUND: The incidence, determinants, and outcome of postoperative atrial
fibrillation (AF) after surgery for mitral regurgitation (MR) are poorly defined
but may have important implications for timing of mitral valve surgery. METHODS AND
RESULTS: In 762 patients in sinus rhythm with no AF history undergoing MR surgical
correction, we examined the rates and prognostic implications of postoperative AF
for early AF (within 2 weeks postoperatively) and late AF (>2 weeks after surgery).
During postoperative follow-up, 180 patients (24%) experienced new AF (early AF in
136 and late AF in 111). Isolated early AF without recurrence was observed in 69
patients characterized by high angina class and lower left ventricular ejection
fraction but no significant left atrial (LA) enlargement. However, overall early AF
predicted late AF: 62+/-5% of patients with early AF had late AF at 10 years
compared with 9+/-1% of patients without early AF (P<0.0001). Large LA size
strongly and independently predicted early AF (P=0.01) and late AF (P=0.003). For
late AF, the predictive value of an enlarged LA was cumulative to that of early AF.
Postoperative AF was associated with an increased subsequently higher risk of
stroke or congestive heart failure (adjusted risk ratio=1.46 [1.04 to 2.05],
P=0.03). CONCLUSIONS: Postoperative AF is common after surgical correction of MR in
patients with no prior history of AF and is associated with increased subsequent
morbidity. LA enlargement is independently predictive of postoperative AF and as
such, should be integrated into the clinical decision-making process in patients
with MR.
AD - Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic,
Rochester, Minn 55905, USA.
AN - 15477410
AU - Kernis, S. J.
AU - Nkomo, V. T.
AU - Messika-Zeitoun, D.
AU - Gersh, B. J.
AU - Sundt, T. M., 3rd
AU - Ballman, K. V.
AU - Scott, C. G.
AU - Schaff, H. V.
AU - Enriquez-Sarano, M.
DA - Oct 19
DO - 10.1161/01.Cir.0000145121.25259.54
DP - NLM
ET - 2004/10/13
IS - 16
J2 - Circulation
KW - Aged
Aged, 80 and over
Angina Pectoris/epidemiology
Atrial Fibrillation/epidemiology/*etiology
Comorbidity
Female
Follow-Up Studies
Humans
Hypertrophy
Incidence
Male
Middle Aged
Mitral Valve Insufficiency/*surgery
Postoperative Complications/epidemiology/*etiology
Prognosis
Recurrence
Risk Factors
Stroke Volume
Time Factors
Treatment Outcome
LA - eng
N1 - 1524-4539
Kernis, Steven J
Nkomo, Vuyisile T
Messika-Zeitoun, David
Gersh, Bernard J
Sundt, Thoralf M 3rd
Ballman, Karla V
Scott, Christopher G
Schaff, Hartzell V
Enriquez-Sarano, Maurice
Journal Article
United States
Circulation. 2004 Oct 19;110(16):2320-5. doi: 10.1161/01.CIR.0000145121.25259.54.
Epub 2004 Oct 11.
PY - 2004
SN - 0009-7322
SP - 2320-5
ST - Atrial fibrillation after surgical correction of mitral regurgitation in
sinus rhythm: incidence, outcome, and determinants
T2 - Circulation
TI - Atrial fibrillation after surgical correction of mitral regurgitation in
sinus rhythm: incidence, outcome, and determinants
VL - 110
ID - 2703
ER -
TY - JOUR
AB - BACKGROUND: The Canadian Trial of Physiological Pacing (CTOPP) reported that
the risk of stroke or cardiovascular death was similar between patients receiving
ventricular versus physiological pacemakers at the end of the original follow-up
period of 3 years. However, the occurrence of atrial fibrillation was significantly
less frequent with physiological pacemakers. To assess a potential delayed benefit
of physiological pacing, follow-up of patients in this study was extended to 6
years. METHODS AND RESULTS: A total of 1474 patients requiring a pacemaker for
symptomatic bradycardia were randomized to receive ventricular and 1094 to
physiological pacemakers. The primary outcome was stroke or cardiovascular death.
The study was completed in July 1998, and follow-up was extended to July 2001. At a
mean follow-up of 6.4 years, there was no difference between treatment groups in
the primary outcome of cardiovascular death or stroke. There was no significant
difference in total mortality or stroke between groups. There was a significantly
lower rate of development of atrial fibrillation in the physiological group, with a
relative risk reduction of 20.1% (CI, 5.4 to 32.5; P=0.009). CONCLUSIONS: The CTOPP
extended study does not show a difference in cardiovascular death or stroke, or in
total mortality, or in stroke between patients implanted with ventricular or
physiological pacemakers over a mean follow-up of >6 years. However, there is a
persistent significant reduction in the development of atrial fibrillation with
physiological pacing.
AD - Room 344, Division of Cardiology, St Paul's Hospital, 1081 Burrard St,
Vancouver, BC, Canada, V6Z 1Y6. ckerr@providencehealth.bc.ca
AN - 14707022
AU - Kerr, C. R.
AU - Abdollah, H.
AU - Roberts, R. S.
AU - Gent, M.
AU - Yusuf, S.
AU - Gillis, A. M.
AU - Tang, A. S.
AU - Talajic, M.
AU - Klein, G. J.
AU - Newman, D. M.
DA - Jan 27
DO - 10.1161/01.Cir.0000109490.72104.Ee
DP - NLM
ET - 2004/01/07
IS - 3
J2 - Circulation
KW - Atrial Fibrillation/epidemiology
Bradycardia/therapy
Canada
Follow-Up Studies
Humans
Stroke/epidemiology
Treatment Outcome
LA - eng
N1 - 1524-4539
Kerr, Charles R
Connolly, Stuart J
Abdollah, Hoshiar
Roberts, Robin S
Gent, Michael
Yusuf, Salim
Gillis, Anne M
Tang, Anthony S L
Talajic, Mario
Klein, George J
Newman, David M
Clinical Trial
Journal Article
United States
Circulation. 2004 Jan 27;109(3):357-62. doi: 10.1161/01.CIR.0000109490.72104.EE.
Epub 2004 Jan 5.
PY - 2004
SN - 0009-7322
SP - 357-62
ST - Canadian Trial of Physiological Pacing: Effects of physiological pacing
during long-term follow-up
T2 - Circulation
TI - Canadian Trial of Physiological Pacing: Effects of physiological pacing
during long-term follow-up
VL - 109
ID - 2540
ER -
TY - JOUR
AB - OBJECTIVES: The purpose of this study is to report the prevalence, clinical
characteristics, precipitating factors, management and outcome of patients with
prior stroke hospitalised with acute heart failure (HF). DESIGN: Retrospective
analysis of prospectively collected data. SETTING: Data were derived from Gulf CARE
(Gulf aCute heArt failuRe rEgistry), a prospective multicentre study of consecutive
patients hospitalised with acute HF in 2012 in seven Middle Eastern countries and
analysed according to the presence or absence of prior stroke; demographics,
management and outcomes were compared. PARTICIPANTS: A total of 5005 patients with
HF. OUTCOME MEASURES: In-hospital and 1-year outcome. RESULTS: The prevalence of
prior stroke in patients with HF was 8.1%. Patients with stroke with HF were more
likely to be admitted under the care of internists rather than cardiologists. When
compared with patients without stroke, patients with stroke were more likely to be
older and to have diabetes mellitus, hypertension, atrial fibrillation,
hyperlipidaemia, chronic kidney disease, ischaemic heart disease, peripheral
arterial disease and left ventricular dysfunction (p=0.001 for all). Patients with
stroke were less likely to be smokers (0.003). There were no significant
differences in terms of precipitating risk factors for HF hospitalisation between
the two groups. Patients with stroke with HF had a longer hospital stay (mean±SD
days; 11±14 vs 9±13, p=0.03), higher risk of recurrent strokes and 1-year mortality
rates (32.7% vs 23.2%, p=0.001). Multivariate logistic regression analysis showed
that stroke is an independent predictor of in-hospital and 1-year mortality.
CONCLUSIONS: This observational study reports high prevalence of prior stroke in
patients hospitalised with HF. Internists rather than cardiologists were the
predominant caregivers in this high-risk group. Patients with stroke had higher
risk of in-hospital recurrent strokes and long-term mortality rates. TRIAL
REGISTRATION NUMBER: NCT01467973.
AD - Department of Cardiology, Saint Michael's Hospital, Toronto University,
Canada.
Department of Cardiology, Royal Hospital, Muscat, Oman.
Biostatistics Section, Cardiovascular Research, Heart Hospital, Hamad Medical
Corporation, Doha, Qatar.
Department of Cardiac Sciences, King Fahad Cardiac Center, King Saud University,
Riyadh, Saudi Arabia.
Adult Cardiology, Heart Hospital, Hamad Medical Corporation, Doha, Qatar.
Department of Cardiology, Sheikh Khalifa Medical City, Abu Dhabi, UAE.
Department of Cardiology, Sabah Al-Ahmed Cardiac Center, Kuwait.
Department of Cardiology, Adan Hospital, Kuwait, Kuwait.
Department of Cardiology, Dubai hospital, Dubai, UAE.
Department of Cardiology, Mohammed Bin Khalifa Cardiac Center, Manamah, Bahrain.
Department of Cardiology, Faculty of Medicine, Sana'a University, Sana'a, Yemen.
Department of Cardiology, Prince Salman Heart Center, King Fahad Medical City,
Saudi Arabia Department or Cardiology, Tanta University, Tanta, Egypt.
Biostatistics Section, Cardiovascular Research, Heart Hospital, Hamad Medical
Corporation, Doha, Qatar Qatar Cardiovascular Research Center and Adult Cardiology,
Heart Hospital, Hamad Medical Corporation, Doha, Qatar.
AN - 25908674
AU - Khafaji, H. A.
AU - Sulaiman, K.
AU - Singh, R.
AU - AlHabib, K. F.
AU - Asaad, N.
AU - Alsheikh-Ali, A.
AU - Al-Jarallah, M.
AU - Bulbanat, B.
AU - AlMahmeed, W.
AU - Ridha, M.
AU - Bazargani, N.
AU - Amin, H.
AU - AlFaleh, H.
AU - Elasfar, A.
AU - Panduranga, P.
AU - Al Suwaidi, J.
C2 - PMC4410120
DA - Apr 23
DO - 10.1136/bmjopen-2014-007148
DP - NLM
ET - 2015/04/25
IS - 4
J2 - BMJ open
KW - Aged
Atrial Fibrillation/epidemiology
Cardiology
Cohort Studies
Comorbidity
Disease Management
Female
Heart Failure/*mortality/therapy
Hospital Mortality
*Hospitalization
Humans
Hyperlipidemias/epidemiology
Internal Medicine
Length of Stay
Logistic Models
Male
Middle Aged
Middle East/epidemiology
Peripheral Arterial Disease/epidemiology
Precipitating Factors
Prevalence
Prognosis
Prospective Studies
Recurrence
*Registries
Renal Insufficiency, Chronic/epidemiology
Risk Factors
Stroke medicine
LA - eng
N1 - 2044-6055
Khafaji, Hadi A R
Sulaiman, Kadhim
Singh, Rajvir
AlHabib, Khalid F
Asaad, Nidal
Alsheikh-Ali, Alawi
Al-Jarallah, Mohammed
Bulbanat, Bassam
AlMahmeed, Wael
Ridha, Mustafa
Bazargani, Nooshin
Amin, Haitham
Al-Motarreb, Ahmed
AlFaleh, Hussam
Elasfar, Abdelfatah
Panduranga, Prashanth
Al Suwaidi, Jassim
Journal Article
Observational Study
BMJ Open. 2015 Apr 23;5(4):e007148. doi: 10.1136/bmjopen-2014-007148.
PY - 2015
SN - 2044-6055
SP - e007148
ST - Clinical characteristics, precipitating factors, management and outcome of
patients with prior stroke hospitalised with heart failure: an observational report
from the Middle East
T2 - BMJ Open
TI - Clinical characteristics, precipitating factors, management and outcome of
patients with prior stroke hospitalised with heart failure: an observational report
from the Middle East
VL - 5
ID - 2938
ER -
TY - JOUR
AB - We report a case of a patient with long-standing persistent atrial
fibrillation (AF) who had rapid formation of spontaneous echo-contrast in the left
atrium during pulmonary vein antrum isolation set off by a vagally mediated pause
despite standard anticoagulation protocol. Spontaneous echo contrast resolved with
ventricular pacing, representing visual evidence for dependence of some AF patients
with poor atrial transport function on ventricular emptying with potential greater
risk of thromboembolism related to a long ventricular pause.
AD - Heart Rhythm Program, Division of Cardiology, Southlake Regional Health
Center, Newmarket, ON, Canada. y.khaykin@utoronto.ca
AN - 21724652
AU - Khaykin, Y.
AU - Wulffhart, Z. A.
AU - Verma, A.
DA - Dec
DO - 10.1093/europace/eur203
DP - NLM
ET - 2011/07/05
IS - 12
KW - Atrial Fibrillation/*surgery
Echocardiography
Electrocardiography
Humans
Male
Middle Aged
Pulmonary Veins/*surgery
Stroke/diagnosis/etiology
Thromboembolism/complications/pathology
Vagus Nerve/*physiopathology
LA - eng
N1 - 1532-2092
Khaykin, Yaariv
Wulffhart, Zaev A
Verma, Atul
Case Reports
Journal Article
England
Europace. 2011 Dec;13(12):1797-8. doi: 10.1093/europace/eur203. Epub 2011 Jul 1.
PY - 2011
SN - 1099-5129
SP - 1797-8
ST - Left atrial 'sludge' during vagally mediated pause triggered by pulmonary
vein antral ablation
T2 - Europace
TI - Left atrial 'sludge' during vagally mediated pause triggered by pulmonary
vein antral ablation
VL - 13
ID - 2771
ER -
TY - JOUR
AB - The aim of this study was to investigate what factor determines tachycardia-
induced secretion of atrial and brain natriuretic peptides (ANP and BNP,
respectively) in patients with hypertrophic cardiomyopathy (HCM). HCM patients with
normal left ventricular (LV) systolic function and intact coronary artery (n = 22)
underwent rapid atrial pacing test. The cardiac secretion of ANP and BNP and the
lactate extraction ratio (LER) were evaluated by using blood samples from the
coronary sinus and aorta. LV end-diastolic pressure (LVEDP) and the time constant
of LV relaxation of tau were measured by a catheter-tip transducer. These
parameters were compared with normal controls (n = 8). HCM patients were divided
into obstructive (HOCM) and nonobstructive (HNCM) groups. The cardiac secretion of
ANP was significantly increased by rapid pacing in HOCM from 384 +/- 101 to 1,268
+/- 334 pg/ml (P < 0.05); however, it was not significant in control and HNCM
groups. In contrast, the cardiac secretion of BNP was fairly constant and rather
significantly decreased in HCM (P < 0.01). The cardiac ANP secretion was
significantly correlated with changes in LER (r = -0.57, P < 0.01) and tau (r =
0.73, P < 0.001) in HCM patients. Tachycardia potentiates the cardiac secretion of
ANP, not BNP, in patients with HCM, particularly when it induces myocardial
ischemia and LV diastolic dysfunction.
AD - First Department of Internal Medicine, Asahikawa Medical College, 2-1-1-1
Midorigaoka Higashi, Asahikawa, Hokkaido 078-8510, Japan.
AN - 16172169
AU - Kido, S.
AU - Hasebe, N.
AU - Ishii, Y.
AU - Kikuchi, K.
DA - Mar
DO - 10.1152/ajpheart.00110.2005
DP - NLM
ET - 2005/09/21
IS - 3
J2 - American journal of physiology. Heart and circulatory physiology
KW - Atrial Natriuretic Factor/*blood
Cardiac Pacing, Artificial/adverse effects
Cardiomyopathy, Hypertrophic/*blood/etiology
Female
Humans
Male
Middle Aged
Myocardial Ischemia/*blood/etiology
Tachycardia/*blood/complications
Ventricular Dysfunction, Left/*blood/etiology
LA - eng
N1 - Kido, Shinsuke
Hasebe, Naoyuki
Ishii, Yoshinao
Kikuchi, Kenjiro
Journal Article
United States
Am J Physiol Heart Circ Physiol. 2006 Mar;290(3):H1064-70. doi:
10.1152/ajpheart.00110.2005. Epub 2005 Sep 19.
PY - 2006
SN - 0363-6135 (Print)
0363-6135
SP - H1064-70
ST - Tachycardia-induced myocardial ischemia and diastolic dysfunction potentiate
secretion of ANP, not BNP, in hypertrophic cardiomyopathy
T2 - Am J Physiol Heart Circ Physiol
TI - Tachycardia-induced myocardial ischemia and diastolic dysfunction potentiate
secretion of ANP, not BNP, in hypertrophic cardiomyopathy
VL - 290
ID - 3012
ER -
TY - JOUR
AB - OBJECTIVE: Apical hypertrophic cardiomyopathy (HCM) is characterised by
apical systolic obliteration and is associated with atrial fibrillation (AF),
stroke, heart failure (HF), and mortality. We investigated whether apical
obliteration of the left ventricular (LV) cavity could have an unfavourable impact
on the clinical course of apical HCM. METHODS: 188 patients with apical HCM (114
males, median age 67 years) were identified retrospectively from January 2008 to
December 2010. The rate of apical obliteration was defined as the net obliteration
to end-diastolic apical cap thickness, and the ratio of obliteration to cavity was
defined as the end-systolic obliteration to cavity height. Events were defined as a
composite of new onset of AF, stroke, HF, and cardiovascular (CV) death. RESULTS:
There were 43 clinical events (19 AFs, 11 HFs, 9 strokes, and 4 deaths) during a
follow-up of median 4.4 years. The events patients were older, had larger left
atrial volume index (LAVI), lower late diastolic mitral annular tissue Doppler
velocity (a'), and higher LV end-diastolic pressure (E/e'). They had greater apical
thickness and obliteration, smaller systolic cavity height, higher rate of
obliteration, and higher ratio of obliteration to cavity; events were significantly
higher (54%) in the upper tertiles of the ratio of obliteration to cavity. Age,
E/e', a', LAVI, apical thickness, rate of obliteration, and ratio of obliteration
to cavity were associated with events. On multivariable analysis, the ratio of
obliteration to cavity remained a significant predictor. CONCLUSIONS: The ratio of
obliteration to cavity could provide useful information to predict the occurrence
of adverse events in apical HCM.
AD - Division of Cardiology, Department of Internal Medicine, Keimyung University
Dongsan Medical Center, Daegu, Republic of Korea.
AN - 26969633
AU - Kim, H.
AU - Park, J. H.
AU - Won, K. B.
AU - Yoon, H. J.
AU - Park, H. S.
AU - Cho, Y. K.
AU - Nam, C. W.
AU - Han, S.
AU - Hur, S. H.
AU - Kim, Y. N.
AU - Kim, K. B.
DA - Aug 1
DO - 10.1136/heartjnl-2015-309121
DP - NLM
ET - 2016/03/13
IS - 15
KW - Aged
Cardiomyopathy, Hypertrophic/complications/*diagnostic
Female
Humans
Male
Middle Aged
Prognosis
Republic of Korea
Risk Factors
Stroke/etiology
Systole
Time Factors
Ventricular Dysfunction, Left/*diagnostic
imaging/etiology/mortality/physiopathology
LA - eng
N1 - 1468-201x
Kim, Hyungseop
Park, Jung-Ho
Won, Ki-Bum
Yoon, Hyuck-Jun
Park, Hyoung-Seob
Cho, Yun-Kyeong
Nam, Chang-Wook
Han, Seongwook
Hur, Seung-Ho
Kim, Yoon-Nyun
Kim, Kwon-Bae
Journal Article
Observational Study
England
Heart. 2016 Aug 1;102(15):1215-20. doi: 10.1136/heartjnl-2015-309121. Epub 2016 Mar
11.
PY - 2016
SN - 1355-6037
SP - 1215-20
ST - Significance of apical cavity obliteration in apical hypertrophic
cardiomyopathy
T2 - Heart
TI - Significance of apical cavity obliteration in apical hypertrophic
cardiomyopathy
VL - 102
ID - 2877
ER -
TY - JOUR
AB - BACKGROUND: Some ischemic strokes in patients with atrial fibrillation (AF)
are caused by noncardioembolic etiologies (AF-unrelated stroke), but not AF itself
(AF-related stroke). However, most clinical trials on the risk of stroke in AF have
not distinguished between these. We investigated the frequency and features of AF-
unrelated versus AF-related strokes in patients with AF plus ischemic stroke. We
hypothesized that certain clinical factors, including chronicity of AF, treatment
at the time of stroke onset and echocardiographic findings, may help to
discriminate between AF-related and AF-unrelated strokes. The mechanisms and
antithrombotic medications at the time of stroke recurrence in the two groups were
also examined. METHODS: Consecutive patients with ischemic stroke within 7 days of
symptom onset and with AF were included. Patients were classified according to the
previously published criteria. Clinical factors including CHADS2 and CHA2DS2-VASc
scores and transthoracic echocardiographic (TTE) findings were evaluated. RESULTS:
Of 522 patients, 424 (81.2%) were grouped as AF-related stroke and the remaining 90
(17.2%) were classified as AF-unrelated stroke. Among the patients with AF-
unrelated stroke, 51 (9.8%) were categorized as possible large artery
atherosclerosis and 38 (7.3%) as possible small artery occlusion; 1 patient (0.2%)
was assigned to miscellaneous cause. The AF-related and AF-unrelated strokes had
similar CHADS2 and CHA2DS2-VASc scores. However, compared to AF-unrelated stroke,
AF-related stroke was independently associated with female sex (odds ratio, OR,
2.19; 95% confidence interval, CI, 1.18-4.05), sustained AF (OR, 2.09; 95% CI,
1.21-3.59), inadequate anticoagulation at stroke onset (OR, 3.21; 95% CI, 1.33-
7.75) and left ventricular dysfunction on TTE (OR, 2.84; 95% CI, 1.40-5.74). We
identified 26 patients who experienced 2 strokes during the study period. The
initial stroke subtype was a strong predictor of the recurrent stroke mechanism (p
< 0.001). Among 17 events of AF-related recurrent stroke in these subpopulation,
only 2 strokes (11.8%) occurred in a setting of adequate anticoagulation, whereas 4
out of 9 patients (44.4%) who had AF-unrelated strokes at recurrence were
sufficiently anticoagulated at the time of admission (p = 0.138). CONCLUSION: AF is
not always a culprit of stroke in patients with AF plus ischemic stroke;
approximately one sixth of these cases are unrelated to AF and have distinct
characteristics compared to AF-related stroke. There are significant differences in
terms of some clinical and TTE parameters between AF-related and AF-unrelated
stroke. Future studies are warranted to optimize strategies for risk
stratification, treatment and prevention of stroke in these patients.
AD - Department of Neurology, Samsung Medical Center, Sungkyunkwan University
School of Medicine, Seoul, South Korea.
AN - 24217395
AU - Kim, S. J.
AU - Ryoo, S.
AU - Kwon, S.
AU - Park, Y. K.
AU - Kim, J. P.
AU - Lee, G. Y.
AU - Bang, O. Y.
DO - 10.1159/000355571
DP - NLM
ET - 2013/11/13
IS - 5-6
KW - Adult
Aged
Aged, 80 and over
Atrial Fibrillation/*complications/therapy
Female
Humans
Ischemia/*complications/therapy
Male
Middle Aged
Patient Selection
Prognosis
Risk Assessment
Risk Factors
Stroke/*etiology/therapy
LA - eng
N1 - 1421-9786
Kim, Suk Jae
Ryoo, Sookyung
Kwon, Soonwook
Park, Yun Kyung
Kim, Jun Pyo
Lee, Ga Yeon
Bang, Oh Young
Journal Article
Switzerland
Cerebrovasc Dis. 2013;36(5-6):373-82. doi: 10.1159/000355571. Epub 2013 Nov 9.
PY - 2013
SN - 1015-9770
SP - 373-82
ST - Is atrial fibrillation always a culprit of stroke in patients with atrial
fibrillation plus stroke?
TI - Is atrial fibrillation always a culprit of stroke in patients with atrial
fibrillation plus stroke?
VL - 36
ID - 2643
ER -
TY - JOUR
AB - BACKGROUND: Mitral regurgitation (MR) is a frequent complication of left-
ventricular dysfunction, with an incidence ranging from 13 to 59% after acute
myocardial infarction (AMI), which is associated with poor clinical outcome. The
aim of this study was to assess the clinical and angiographic characteristics
associated with MR, the incidence and predictors of MR, and the outcomes of MR
after AMI in those who were successfully treated with primary percutaneous coronary
intervention (PCI) using a drug-eluting stent. METHODS: We analyzed a multicenter
all-comer AMI registry and identified 4748 patients between January 2004 and
December 2009. Of these, 1894 patients were treated with PCI using a drug-eluting
stent and had MR. The association between MR and the composite of major adverse
cardiac and cerebrovascular events (MACCE; all-cause death, recurrent nonfatal
myocardial infarction, stroke, and any revascularization) was examined. RESULTS:
Patients with MR after the index PCI showed significantly higher cumulative
incidence of MACCE compared with no-MR patients over the 5-year survival period
(P=0.002). When the MR groups were compared on the basis of the severity of MR,
ranging from mild to severe grades, a higher grade of MR was found to be associated
with a higher incidence of MACCE (P<0.001). Multivariate Cox proportional hazard
analysis revealed that no reflow, left-ventricular ejection fraction less than 50%,
and anemia, in addition to MR, were consistently associated with increased all-
cause death during the 5-year period (adjusted hazard ratio 1.408, 95% confidence
interval 1.052-1.884, P=0.021). CONCLUSION: MR after AMI in patients successfully
treated with primary PCI was associated with poor long-term outcome regardless of
ST-segment elevation at diagnosis during the drug-eluting stent era.
AD - aDepartment of Internal Medicine, Division of Cardiology, Seoul St Mary's
Hospital bDepartment of Internal Medicine, Division of Cardiology, St Paul's
Hospital cDepartment of Internal Medicine, Division of Cardiology, Yeouido St
Mary's Hospital, The Catholic University of Korea, Seoul dDepartment of Internal
Medicine, Division of Cardiology, Daejeon St Mary's Hospital, The Catholic
University of Korea, Daejeon eDepartment of Internal Medicine, Division of
Cardiology, Uijeongbu St Mary's Hospital, The Catholic University of Korea,
Uijengbu fDepartment of Internal Medicine, Division of Cardiology, Bucheon St
Mary's Hospital, The Catholic University of Korea, Bucheon gDepartment of Internal
Medicine, Division of Cardiology, St Vincent's Hospital, The Catholic University of
Korea, Suwon hDepartment of Internal Medicine, Division of Cardiology, Incheon St
Mary's Hospital, The Catholic University of Korea, Incheon iDepartment of Internal
Medicine, Division of Cardiology, Chonnam National University Hospital, Chonnam
National University, Gwangju, Korea.
AN - 26626143
AU - Kim, T. H.
AU - Lee, K. Y.
AU - Choi, Y.
AU - Park, H. W.
AU - Lee, Y. S.
AU - Koh, Y. S.
AU - Park, H. J.
AU - Kim, P. J.
AU - Chang, K.
AU - Chung, W. S.
AU - Kim, D. B.
AU - Her, S. H.
AU - Park, C. S.
AU - Lee, J. M.
AU - Kim, H. Y.
AU - Yoo, K. D.
AU - Jeon, D. S.
AU - Ahn, Y.
AU - Jeong, M. H.
AU - Seung, K. B.
DA - Mar
DO - 10.1097/mca.0000000000000324
DP - NLM
ET - 2015/12/03
IS - 2
KW - Age Factors
Aged
*Drug-Eluting Stents
Female
Humans
Hypercholesterolemia/epidemiology
Incidence
Male
Middle Aged
Mitral Valve Insufficiency/*etiology
Mortality
Myocardial Infarction/complications/epidemiology/*surgery
Myocardial Revascularization/statistics & numerical data
No-Reflow Phenomenon/epidemiology
Prognosis
Recurrence
*Registries
Risk Factors
Stroke/epidemiology
Stroke Volume
Ventricular Dysfunction, Left/etiology/physiopathology
LA - eng
N1 - 1473-5830
Kim, Tae-Hoon
Lee, Kwan Yong
Choi, Young
Park, Ha-Wook
Lee, Young Soo
Koh, Yoon Seok
Park, Hun-Jun
Kim, Pum-Joon
Chang, Kiyuk
Chung, Wook Sung
Kim, Dong-Bin
Her, Sung-Ho
Park, Chul Soo
Lee, Jong Min
Kim, Hee-Yeol
Yoo, Ki Dong
Jeon, Doo Soo
Ahn, Youngkeun
Jeong, Myung-Ho
Seung, Ki-Bae
Journal Article
England
Coron Artery Dis. 2016 Mar;27(2):109-15. doi: 10.1097/MCA.0000000000000324.
PY - 2016
SN - 0954-6928
SP - 109-15
ST - Prognostic importance of mitral regurgitation complicated by acute myocardial
infarction during a 5-year follow-up period in the drug-eluting stent era
TI - Prognostic importance of mitral regurgitation complicated by acute myocardial
infarction during a 5-year follow-up period in the drug-eluting stent era
VL - 27
ID - 2858
ER -
TY - JOUR
AB - BACKGROUND: Although the degree of electroanatomical remodeling of the left
atrium (LA) is influenced by left ventricular (LV) diastolic function, clinical
implications of estimated LV filling pressure (E/Em) are limited in patients with
atrial fibrillation (AF). We hypothesized that increased E/Em is related to an
advanced LA remodeling, a high CHA2DS2-VASc score, and the presence of stroke or
transient ischemic attack (TIA) in patients with paroxysmal AF. METHODS: We
included 1098 patients with paroxysmal AF (male 74.5%, 57.6±11.3 years old) who
underwent AF catheter ablation. We compared E/Em to clinical parameters,
echocardiography, and three-dimensional-computed tomography findings. RESULTS: The
E/Em>15 group (n=98) was older (p<0.001) and had more females (p<0.001), greater LA
volume index (p<0.001), higher CHA2DS2-VASc score (p<0.001), and stroke/TIA
prevalence (p=0.001) than groups with an E/Em of 8-15 (n=676) or <8 (n=324). An
E/Em was independently associated with the presence of stroke/TIA (OR 1.638, 95% CI
1.050-2.554, p=0.030) after adjusting for age, sex, body surface area, LA volume
index, and LA appendage volume index. CONCLUSIONS: In patients with paroxysmal AF,
the elevated LV filling pressure estimated by E/Em is independently associated with
the presence of stroke or TIA.
AD - Yonsei University Health System, Seoul, Republic of Korea.
Yonsei University Health System, Seoul, Republic of Korea. Electronic address:
hnpak@yuhs.ac.
AN - 26603328
AU - Kim, T. H.
AU - Shim, C. Y.
AU - Park, J. H.
AU - Nam, C. M.
AU - Uhm, J. S.
AU - Joung, B.
AU - Lee, M. H.
AU - Pak, H. N.
DA - Aug
DO - 10.1016/j.jjcc.2015.10.008
DP - NLM
ET - 2015/11/26
IS - 2
KW - Age Factors
Aged
Atrial Appendage/physiopathology
Atrial Fibrillation/*complications/physiopathology/surgery
*Atrial Remodeling
Echocardiography
Female
Humans
Male
Middle Aged
Risk Factors
Sex Factors
Stroke/*etiology
Stroke Volume
Ventricular Dysfunction, Left/*complications/physiopathology
*Catheter ablation
*Left ventricular filling pressure
*Stroke
LA - eng
N1 - 1876-4738
Kim, Tae-Hoon
Shim, Chi Young
Park, Jae Hyung
Nam, Chung Mo
Uhm, Jae-Sun
Joung, Boyoung
Lee, Moon-Hyoung
Pak, Hui-Nam
Journal Article
Netherlands
J Cardiol. 2016 Aug;68(2):104-9. doi: 10.1016/j.jjcc.2015.10.008. Epub 2015 Nov 18.
PY - 2016
SN - 0914-5087
SP - 104-9
ST - Left ventricular diastolic dysfunction is associated with atrial remodeling
and risk or presence of stroke in patients with paroxysmal atrial fibrillation
T2 - J Cardiol
TI - Left ventricular diastolic dysfunction is associated with atrial remodeling
and risk or presence of stroke in patients with paroxysmal atrial fibrillation
VL - 68
ID - 2416
ER -
TY - JOUR
AB - BACKGROUND AND PURPOSE: In many cardioembolic strokes (CSs), the specific
embolic source is uncertain. Despite the high mortality of CS, not enough attention
is paid to its potential source. Although atrial fibrillation (AF) is the most
common source of embolism, more complex and dynamic multiplicities may influence
CS. The aim of this study was to evaluate novel indicators of transthoracic
echocardiography (TTE) that have additional value for detecting CS. METHODS: In
total, 1878 patients with acute ischaemic stroke who had TTE during admission were
identified. Of the patients with undetermined etiology, 93 patients with incomplete
evaluations were excluded. Thereafter, two stroke neurologists reviewed all of the
magnetic resonance images to assess cardioembolic lesion patterns. The patients
were classified into two groups: potential cardioembolic stroke (PCS) and non-PCS.
RESULTS: Amongst a total of 1601 patients, 518 (32.4%) had PCS. About half of the
patients with PCS had AF. Patients with PCS were more likely to have larger left
ventricular (LV) end-diastolic diameters, larger LV end-systolic diameters, larger
left atrial sizes, increased E/A ratios and reduced LV ejection fractions. After
adjusting for multiple clinical and TTE variables including AF, an E/A ratio ≥1.5
had a significant predictive value for PCS (odds ratio 2.89, 95% confidence
interval 1.57-5.31, P < 0.01). CONCLUSION: An E/A ratio ≥1.5 is independently
associated with PCS after adjusting for multiple covariates including AF and
provides incremental prognostic information for detecting PCS.
AD - Department of Neurology, Seoul National University Hospital, Seoul, Korea.
Department of Neurology, Catholic University of Korea Bucheon St Mary's Hospital,
Gyeonggido, Korea.
Department of Cardiology, Seoul National University Hospital, Seoul, Korea.
Clinical Research Center, Asan Medical Center, Seoul, Korea.
AN - 26601639
AU - Kim, Y.
AU - Kim, T. J.
AU - Park, J. B.
AU - Lee, S.
AU - Kim, Y. J.
AU - Lee, J. S.
AU - Lee, S. H.
DA - Mar
DO - 10.1111/ene.12909
DP - NLM
ET - 2015/11/26
IS - 3
KW - Aged
Aged, 80 and over
Atrial Fibrillation/*diagnosis/epidemiology
Brain Ischemia/*diagnosis/epidemiology
Embolism/*diagnosis/epidemiology
Female
Humans
Male
Middle Aged
*Registries
Ventricular Dysfunction/*diagnosis/epidemiology
echocardiography
embolism
ischaemic stroke
LA - eng
N1 - 1468-1331
Kim, Y
Kim, T J
Park, J-B
Lee, S
Kim, Y-J
Lee, J S
Lee, S-H
Journal Article
England
Eur J Neurol. 2016 Mar;23(3):613-20. doi: 10.1111/ene.12909. Epub 2015 Nov 25.
PY - 2016
SN - 1351-5101
SP - 613-20
ST - Novel echocardiographic indicator for potential cardioembolic stroke
T2 - Eur J Neurol
TI - Novel echocardiographic indicator for potential cardioembolic stroke
VL - 23
ID - 2421
ER -
TY - JOUR
AB - BACKGROUND: Two implantable continuous-flow left ventricular assist devices
(LVADs), DuraHeart (Terumo Heart, Ann Arbor, MI, USA) and EVAHEART (Sun Medical,
Nagano, Japan), were approved in Japan in April 2011. We analyzed the midterm
outcome of patients implanted with these implantable LVADs at the University of
Tokyo Hospital. METHODS AND RESULTS: A total of 31 patients who underwent
implantation of LVADs (10 DuraHeart, 21 EVAHEART) as a bridge to transplantation at
our institution between April 2011 and August 2013 were retrospectively reviewed.
All patients were followed up through December 2013. Seven patients underwent
conversions from NIPRO paracorporeal LVAD (Nipro, Osaka, Japan) to an implantable
LVAD. The mean observation period was 483±239 days (41.0 patient years). Eight
patients were transplanted and one patient showed functional recovery with
subsequent LVAD explantation. Four patients died due to cerebrovascular accident,
empyema, or device malfunction due to pump thrombosis after cerebral bleeding.
Kaplan-Meier analysis revealed 6-, 12-, and 24-month survival rates of 93%, 86%,
and 86%, respectively. The rates of freedom from cerebrovascular accidents and
device-related infections at 1 year after LVAD implantation were 65% and 36%,
respectively. Twenty-nine patients were discharged home after LVAD implantation.
During the period of this study, there were 59 readmissions (53 urgent, 6 elective)
among 22 patients (76%). The overall and urgent readmission rates were 1.66 and
1.49 per patient year, respectively. The common reason for readmission was device-
related infection (31%), followed by cerebrovascular accidents (17%). The total
out-of-hospital time after the primary discharge was 90%. CONCLUSIONS: Our midterm
survival rate after LVAD implantation is satisfactory. However, patients undergoing
LVAD support were often readmitted with adverse events.
AD - Department of Cardiovascular Surgery, Graduate School of Medicine, The
University of Tokyo, Tokyo, Japan.
Department of Therapeutic Strategy for Heart Failure, Graduate School of Medicine,
The University of Tokyo, Tokyo, Japan; Department of Cardiac Surgery, Tokyo
Metropolitan Geriatric Hospital, Tokyo, Japan.
Department of Cardiovascular Medicine, Graduate School of Medicine, The University
of Tokyo, Tokyo, Japan.
Department of Organ Transplantation, The University of Tokyo Hospital, Tokyo,
Japan.
Department of Medical Engineering, The University of Tokyo Hospital, Tokyo, Japan.
Department of Therapeutic Strategy for Heart Failure, Graduate School of Medicine,
The University of Tokyo, Tokyo, Japan; Department of Cardiovascular Medicine,
Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Department of Cardiovascular Surgery, Graduate School of Medicine, The University
of Tokyo, Tokyo, Japan. Electronic address: mono-tky@umin.ac.jp.
AN - 25034705
AU - Kimura, M.
AU - Kinoshita, O.
AU - Nawata, K.
AU - Nishimura, T.
AU - Hatano, M.
AU - Imamura, T.
AU - Endo, M.
AU - Kagami, Y.
AU - Kubo, H.
AU - Kashiwa, K.
AU - Kinugawa, K.
AU - Kyo, S.
AU - Komuro, I.
AU - Ono, M.
DA - May
DO - 10.1016/j.jjcc.2014.06.007
DP - NLM
ET - 2014/07/19
IS - 5
KW - Adult
Female
Follow-Up Studies
Heart Failure/*epidemiology/mortality/*therapy
*Heart Transplantation
*Heart-Assist Devices/adverse effects
Humans
Incidence
Japan/epidemiology
Male
Middle Aged
Stroke/epidemiology
Treatment Outcome
Bridge to transplantation
Heart failure
Implantable left ventricular assist device
Outcome
Readmission
LA - eng
N1 - 1876-4738
Kimura, Mitsutoshi
Kinoshita, Osamu
Nawata, Kan
Nishimura, Takashi
Hatano, Masaru
Imamura, Teruhiko
Endo, Miyoko
Kagami, Yukie
Kubo, Hitoshi
Kashiwa, Koichi
Kinugawa, Koichiro
Kyo, Shunei
Komuro, Issei
Ono, Minoru
Journal Article
Netherlands
J Cardiol. 2015 May;65(5):383-9. doi: 10.1016/j.jjcc.2014.06.007. Epub 2014 Jul 14.
PY - 2015
SN - 0914-5087
SP - 383-9
ST - Midterm outcome of implantable left ventricular assist devices as a bridge to
transplantation: Single-center experience in Japan
T2 - J Cardiol
TI - Midterm outcome of implantable left ventricular assist devices as a bridge to
transplantation: Single-center experience in Japan
VL - 65
ID - 2652
ER -
TY - JOUR
AB - BACKGROUND: Strokes develop even in patients with low CHADS₂ scores, and the
left atrial appendage (LAA) is the embolic source 90% of the time. We focused on
the LAA morphology as a new predictor of strokes. OBJECTIVE: To clarify the
anatomical characteristics of the LAA for risk stratification of strokes in
patients with nonvalvular atrial fibrillation (AF) who have low CHADS₂ scores.
METHODS: Among 80 patients who underwent catheter ablation of AF with contrast-
enhanced computed tomography, the LAA characteristics were compared between 30
patients with histories of strokes and 50 age-matched controls. The LAA anatomy was
classified into 4 types--"cactus," "cauliflower," "chicken wing," and "windsock"--
discriminated by the computed tomography measurements of the length, angle, and
number of lobes of the LAA. RESULTS: The average CHADS₂ score did not differ
significantly between patients with stroke and controls (0.8 ± 0.8 vs 0.6 ± 0.7; P
= .277). Eight (26.7%) patients with stroke had CHA₂DS₂-VASc scores of 0. The left
atrial size, LAA flow velocity, left ventricular function, and serum brain
natriuretic peptide level were also unable to predict strokes. However, a
"cauliflower" LAA, defined as a main lobe of less than 4 cm long without forked
lobes, was significantly more common in patients with stroke (odds ratio 3.857; 95%
confidence interval 1.482-10.037; P = .005). The CHA₂DS₂-VASc score-adjusted
logistic regression analysis revealed the cauliflower LAA as an independent
predictor of a stroke (odds ratio 3.355; 95% confidence interval 1.243-9.055; P = .
017). CONCLUSIONS: The LAA anatomy might be useful for predicting strokes in
patients with nonvalvular AF who have low CHADS₂ scores.
AD - Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.
kimura@z7.keio.jp
AN - 23384894
AU - Kimura, T.
AU - Takatsuki, S.
AU - Inagawa, K.
AU - Katsumata, Y.
AU - Nishiyama, T.
AU - Nishiyama, N.
AU - Fukumoto, K.
AU - Aizawa, Y.
AU - Tanimoto, Y.
AU - Tanimoto, K.
AU - Jinzaki, M.
AU - Fukuda, K.
DA - Jun
DO - 10.1016/j.hrthm.2013.01.036
DP - NLM
ET - 2013/02/07
IS - 6
J2 - Heart rhythm
KW - Aged
Atrial Appendage/diagnostic imaging/pathology
Atrial Fibrillation/complications/diagnostic imaging/surgery
Female
Humans
Logistic Models
Male
Middle Aged
Prognosis
ROC Curve
Risk Assessment
Stroke/epidemiology/*pathology
LA - eng
N1 - 1556-3871
Kimura, Takehiro
Takatsuki, Seiji
Inagawa, Kohei
Katsumata, Yoshinori
Nishiyama, Takahiko
Nishiyama, Nobuhiro
Fukumoto, Kotaro
Aizawa, Yoshiyasu
Tanimoto, Yoko
Tanimoto, Kojiro
Jinzaki, Masahiro
Fukuda, Keiichi
Journal Article
United States
Heart Rhythm. 2013 Jun;10(6):921-5. doi: 10.1016/j.hrthm.2013.01.036. Epub 2013 Feb
4.
PY - 2013
SN - 1547-5271
SP - 921-5
ST - Anatomical characteristics of the left atrial appendage in cardiogenic stroke
with low CHADS2 scores
T2 - Heart Rhythm
TI - Anatomical characteristics of the left atrial appendage in cardiogenic stroke
with low CHADS2 scores
VL - 10
ID - 2638
ER -
TY - JOUR
AB - Atrial fibrillation (AF), the most common atrial arrhythmia, has a complex
aetiology and causes relevant morbidity and mortality due to different mechanisms,
including but not limited to stroke, heart failure, and tachy- or bradyarrhythmia.
Current therapeutic options (rate control, rhythm control, antithrombotic therapy,
'upstream therapy') only prevent a part of this burden of disease. Several new
treatment modalities are therefore under evaluation in controlled trials. Given the
multifold clinical consequences of AF, trials in AF patients should assess the
effect of therapy in each of the main outcome domains. This paper describes an
expert consensus of required outcome parameters in seven relevant outcome domains,
namely death, stroke, symptoms and quality of life, rhythm, left ventricular
function, cost, and emerging outcome parameters. In addition to these
'requirements' for outcome assessment in AF trials, further, more detailed outcome
parameters are described. In addition to a careful selection of a relevant primary
outcome parameter, coverage of outcomes in all major domains of AF-related
morbidity and mortality is desirable for any clinical trial in AF.
AD - Department of Cardiology and Angiology, University Hospital Münster, Albert-
Schweitzer-Strasse 33, D-48149 Münster, Germany. kirchhp@uni-muenster.de
AN - 17897924
AU - Kirchhof, P.
AU - Auricchio, A.
AU - Bax, J.
AU - Crijns, H.
AU - Camm, J.
AU - Diener, H. C.
AU - Goette, A.
AU - Hindricks, G.
AU - Hohnloser, S.
AU - Kappenberger, L.
AU - Kuck, K. H.
AU - Lip, G. Y.
AU - Olsson, B.
AU - Meinertz, T.
AU - Priori, S.
AU - Ravens, U.
AU - Steinbeck, G.
AU - Svernhage, E.
AU - Tijssen, J.
AU - Vincent, A.
AU - Breithardt, G.
DA - Nov
DO - 10.1093/eurheartj/ehm358
DP - NLM
ET - 2007/09/28
IS - 22
J2 - European heart journal
Atrial Fibrillation/economics/mortality/*therapy
Costs and Cost Analysis
Electric Countershock/methods
Electrocardiography
Hospitalization
Humans
Quality of Life
Stroke/etiology
Treatment Outcome
LA - eng
N1 - Kirchhof, Paulus
Auricchio, Angelo
Bax, Jeroen
Crijns, Harry
Camm, John
Diener, Hans-Christoph
Goette, Andreas
Hindricks, Gerd
Hohnloser, Stefan
Kappenberger, Lukas
Kuck, Karl-Heinz
Lip, Gregory Y H
Olsson, Bertil
Meinertz, Thomas
Priori, Silvia
Ravens, Ursula
Steinbeck, Gerhard
Svernhage, Elisabeth
Tijssen, Jan
Vincent, Alphons
Breithardt, Günter
Consensus Development Conference
Journal Article
England
Eur Heart J. 2007 Nov;28(22):2803-17. doi: 10.1093/eurheartj/ehm358. Epub 2007 Sep
25.
PY - 2007
SN - 0195-668X (Print)
0195-668x
SP - 2803-17
ST - Outcome parameters for trials in atrial fibrillation: executive summary
T2 - Eur Heart J
TI - Outcome parameters for trials in atrial fibrillation: executive summary
VL - 28
ID - 2532
ER -
TY - JOUR
AB - Atrial fibrillation (AF) causes important mortality and morbidity on a
population-level. So far, we do not have the means to prevent AF or AF-related
complications adequately. Therefore, over 70 experts on atrial fibrillation
convened for the 2nd AFNET/EHRA consensus conference to suggest directions for
research to improve management of AF patients (Appendix 1). The group defined three
main areas in need for research in AF: 1. better understanding of the mechanisms of
AF; 2. Improving rhythm control monitoring and management; and 3. comprehensive
cardiovascular risk management in AF patients. The group put forward the hypothesis
that successful therapy of AF and its associated complications will require
comprehensive therapy. This applies e.g. to the "old" debate of "rate versus rhythm
control", since rhythm control is generally added to underlying (continued) rate
control therapy, but also to the emerging debate of "antiarrhythmic drugs versus
catheter ablation", of which both may be needed in most patients to maintain sinus
rhythm, but also to therapy of conditions that predispose to AF and contribute to
cardiovascular complications such as stroke, cognitive decline, heart failure, and
acute coronary syndromes. We call for research initiatives aiming at a better
understanding of the different causes of AF and its complications, and at
development and validation of mechanism-based therapies. The future of AF therapy
may require a combination of management of underlying and concomitant conditions,
early and comprehensive rhythm control therapy, adequate control of ventricular
rate and cardiac function, and continuous therapy to prevent AF-associated
complications (e.g. antithrombotic therapy). The reasons for these suggestions are
detailed in this paper.
AD - Department of Cardiology and Angiology, University Hospital Münster, Albert-
Schweitzer-Strasse 33, D-48149 Münster, Germany. kirchhp@uni-muenster.de
AN - 19535417
AU - Kirchhof, P.
AU - Bax, J.
AU - Blomstrom-Lundquist, C.
AU - Calkins, H.
AU - Camm, A. J.
AU - Cappato, R.
AU - Cosio, F.
AU - Crijns, H.
AU - Diener, H. C.
AU - Goette, A.
AU - Israel, C. W.
AU - Kuck, K. H.
AU - Lip, G. Y.
AU - Nattel, S.
AU - Page, R. L.
AU - Ravens, U.
AU - Schotten, U.
AU - Steinbeck, G.
AU - Vardas, P.
AU - Waldo, A.
AU - Wegscheider, K.
AU - Willems, S.
AU - Breithardt, G.
DA - Dec
DO - 10.1093/eurheartj/ehp235
DP - NLM
ET - 2009/06/19
IS - 24
Atrial Fibrillation/diagnosis/etiology/*therapy
Humans
Patient Compliance
Risk Factors
Risk Management
LA - eng
N1 - 1522-9645
Kirchhof, Paulus
Bax, Jeroen
Blomstrom-Lundquist, Carina
Calkins, Hugh
Camm, A John
Cappato, Ricardo
Cosio, Francisco
Crijns, Harry
Diener, Hans-Christian
Goette, Andreas
Israel, Carsten W
Kuck, Karl-Heinz
Lip, Gregory Y H
Nattel, Stanley
Page, Richard L
Ravens, Ursula
Schotten, Ulrich
Steinbeck, Gerhard
Vardas, Panos
Waldo, Albert
Wegscheider, Karl
Willems, Stephan
Breithardt, Günter
Journal Article
England
Eur Heart J. 2009 Dec;30(24):2969-77c. doi: 10.1093/eurheartj/ehp235.
PY - 2009
SN - 0195-668x
SP - 2969-77c
ST - Early and comprehensive management of atrial fibrillation: executive summary
of the proceedings from the 2nd AFNET-EHRA consensus conference 'research
perspectives in AF'
T2 - Eur Heart J
TI - Early and comprehensive management of atrial fibrillation: executive summary
of the proceedings from the 2nd AFNET-EHRA consensus conference 'research
perspectives in AF'
VL - 30
ID - 2660
ER -
TY - JOUR
AB - Atrial fibrillation is a common and in most patients recurrent arrhythmia.
Atrial fibrillation can increase mortality and causes at times severe symptoms in
affected patients. Timely initiation of sustained oral anticoagulation is indicated
in patients with atrial fibrillation at risk for stroke to prevent thromboembolic
complications. Patients at risk for stroke can be identified by clinical
characteristics using validated score systems, e.g., the CHADS(2) score or the
Framingham score. Drugs that slow AV nodal conduction can improve symptoms
associated with high ventricular rate. Cardioversion can acutely terminate atrial
fibrillation in almost all patients, but many patients suffer from recurrent atrial
fibrillation. The prevention of arrhythmia recurrences ("rhythm control therapy")
is indicated in patients with severe arrhythmia-related symptoms. Antiarrhythmic
drugs can approximately double the maintenance rate of sinus rhythm. Other drugs
that were not primarily developed as antiarrhythmic agents, e.g., ACE inhibitors,
sartans, and possibly statins, can further improve maintenance of sinus rhythm in
selected patient groups. Catheter-based isolation of the pulmonary veins is a
recently developed intervention that can cure some forms of atrial fibrillation. It
is likely that a multimodal therapeutic approach will in the future allow rhythm
control therapy to become more effective.
AD - Medizinische Klinik und Poliklinik C, Kardiologie und Angiologie,
Universitätsklinikum Münster, Albert-Schweitzer-Strasse 33, 48149 Münster.
kirchhp@uni-muenster.de
AN - 17632695
AU - Kirchhof, P.
AU - Breithardt, G.
DA - Aug
DO - 10.1007/s00108-007-1899-5
DP - NLM
ET - 2007/07/17
IS - 8
J2 - Der Internist
KW - Angiotensin II Type 1 Receptor Blockers/therapeutic use
Atrial Fibrillation/complications/diagnostic imaging/physiopathology/*therapy
Catheter Ablation
Electrocardiography
Endomyocardial Fibrosis/physiopathology
Humans
Pulmonary Veins/diagnostic imaging/surgery
Surgery, Computer-Assisted
LA - ger
N1 - Kirchhof, P
Breithardt, G
Journal Article
Germany
Internist (Berl). 2007 Aug;48(8):819-29; quiz 830-1. doi: 10.1007/s00108-007-1899-
5.
OP - Therapie von Vorhofflimmern.
PY - 2007
SN - 0020-9554 (Print)
0020-9554
SP - 819-29; quiz 830-1
ST - [Treatment of atrial fibrillation]
T2 - Internist (Berl)
TI - [Treatment of atrial fibrillation]
VL - 48
ID - 2725
ER -
TY - JOUR
AD - Department of Graduate School of Medicine (Cardiology), International
University of Health and Welfare, 137-1 Enokizu, Okawa, Fukuoka 8318501, Japan.
Electronic address: tkishi@iuhw.ac.jp.
AN - 32173128
AU - Kishi, T.
DA - Jun 1
DO - 10.1016/j.ijcard.2020.03.010
DP - NLM
ET - 2020/03/17
KW - Arrhythmias, Cardiac
Astrocytes
Humans
*Myocardial Infarction
*Paraventricular Hypothalamic Nucleus
*Astrocytes
*Brain
*Glia
*Sympathetic nervous system
LA - eng
N1 - 1874-1754
Kishi, Takuya
Comment
Editorial
Netherlands
Int J Cardiol. 2020 Jun 1;308:52-53. doi: 10.1016/j.ijcard.2020.03.010. Epub 2020
Mar 6.
PY - 2020
SN - 0167-5273
SP - 52-53
ST - Astrocytes in paraventricular nucleus is a potential therapeutic target for
ventricular arrhythmia with sympathoexcitation after acute myocardial infarction
T2 - Int J Cardiol
TI - Astrocytes in paraventricular nucleus is a potential therapeutic target for
ventricular arrhythmia with sympathoexcitation after acute myocardial infarction
VL - 308
ID - 2786
ER -
TY - JOUR
AB - INTRODUCTION: The underlying mechanism of the residual left atrial thrombus
(LAT)/spontaneous echo contrast (SEC) after the onset of cardioembolic stroke (CES)
is unknown. This study aims to investigate the utility of CHADS(2) and CHA(2)DS(2)-
VASc scores for predicting LAT/SEC, and to investigate the risk factors of residual
LAT/SEC after CES onset. METHODS: This retrospective study included 124 patients
who were admitted with the acute phase of CES at our center. The clinical,
echocardiographic variables, the CHADS(2)/CHA(2)DS(2)-VASc scores, and National
Institutes of Health Stroke Scale score were retrospectively assessed on admission.
RESULTS: Of 124 patients, LAT or SEC was detected in 39 patients (31.5%, 17 LAT and
38 SEC). Univariate analysis showed that the LAT/SEC group had a higher prevalence
of nonparoxysmal atrial fibrillation (AF), left ventricular (LV) hypertrophy,
hypertension, the rate of anticoagulation before admission, higher National
Institutes of Health Stroke Scale score, larger left atrial diameter, and elevated
E wave. In contrast, the CHADS(2) and CHA(2)DS(2)-VASc scores were not associated
with LAT/SEC. LAT/SEC was associated with nonparoxysmal AF and LV hypertrophy on
multivariate analysis. Moreover, all patients were divided into 4 groups based on
the combination between non-paroxysmal AF and LV hypertrophy. The rate of LAT/SEC
was the highest (87.5%) in patients with nonparoxysmal AF and LV hypertrophy.
CONCLUSIONS: Nonparoxysmal atrial fibrillation and left ventricular hypertrophy
were associated with residual left atrial thrombus/spontaneous echo contrast in the
acute phase after cardioembolic stroke that was independent of the CHADS(2) and
CHA(2)DS(2)-VASc scores.
AD - Department of Internal Medicine, Cardiovascular Division, Hyogo College of
Medicine, Nishinomiya, Japan. Electronic address: kishima@hyo-med.ac.jp.
Department of Internal Medicine, Cardiovascular Division, Hyogo College of
Medicine, Nishinomiya, Japan.
Department of Neurosurgery, Hyogo College of Medicine, Nishinomiya, Japan.
AN - 30930240
AU - Kishima, H.
AU - Mine, T.
AU - Fukuhara, E.
AU - Ashida, K.
AU - Uchida, K.
AU - Yoshimura, S.
AU - Ishihara, M.
DA - Jun
DP - NLM
ET - 2019/04/02
IS - 6
KW - Aged
Aged, 80 and over
Atrial Fibrillation/*diagnostic imaging/epidemiology
Databases, Factual
Electrocardiography
Female
Humans
Hypertrophy, Left Ventricular/*diagnostic imaging/epidemiology
Intracranial Embolism/diagnostic imaging/*epidemiology
Japan/epidemiology
Male
Middle Aged
Prevalence
Risk Assessment
Risk Factors
Thrombosis/*diagnostic imaging/epidemiology
Atrial fibrillation
Stroke
Thrombus
LA - eng
N1 - 1532-8511
Kishima, Hideyuki
Mine, Takanao
Fukuhara, Eiji
Ashida, Kenki
Uchida, Kazutaka
Yoshimura, Shinichi
Ishihara, Masaharu
Journal Article
United States
J Stroke Cerebrovasc Dis. 2019 Jun;28(6):1571-1577. doi:
10.1016/j.jstrokecerebrovasdis.2019.03.003. Epub 2019 Mar 29.
PY - 2019
SN - 1052-3057
SP - 1571-1577
ST - Predictors of Left Atrial Thrombi and Spontaneous Echocardiographic Contrast
in the Acute Phase After Cardioembolic Stroke in Patients With Atrial Fibrillation
TI - Predictors of Left Atrial Thrombi and Spontaneous Echocardiographic Contrast
in the Acute Phase After Cardioembolic Stroke in Patients With Atrial Fibrillation
VL - 28
ID - 2311
ER -
TY - JOUR
AB - BACKGROUND: Intravenous levosimendan is indicated for acute heart failure.
The compound has shown promising beneficial effects in ischemic stroke models.
OBJECTIVE: We evaluated the efficacy and safety of oral levosimendan in patients
with a history of cerebral ischemia. METHODS: In a randomized, double-blind,
placebo-controlled, parallel-group study, 16 patients with a history of ischemic
stroke/transient ischemic attack received oral levosimendan in 5 escalating doses
from 0.125 to 2.0 mg daily for 18-day intervals of each dose; 5 patients received
placebo. Twenty-four-hour ambulatory ECG and cerebral blood flow velocities using
transcranial Doppler ultrasound were recorded at baseline and at the end of each
dosing period. Vasomotor reactivity was assessed via the breath holding index. In
addition, plasma levels of N-terminal-pro-B-type natriuretic peptide (NT-pro-BNP)
and the metabolites of levosimendan were determined. RESULTS: Levosimendan induced
an increase in cerebral blood flow velocities and a decrease in NT-pro-BNP compared
with placebo. There was no significant effect on breath holding index. Doses ≥0.5
mg increased heart rate by 5 to 9 beats/min. The dose level of 2.0 mg exceeded the
preset safety margin of ventricular extrasystoles per hour (ie, upper 90% CI of the
ratio of levosimendan to placebo above 2) with an estimate of 3.10 (90% CI, 0.95-
10.07). CONCLUSIONS: Oral levosimendan increases cerebral blood flow velocities and
diminishes NT-pro-BNP levels in patients with earlier ischemic cerebrovascular
event. Daily doses up to 1.0 mg were well tolerated, whereas the 2.0 mg dose level
induced an increase in ventricular extrasystoles. ClinicalTrials.gov identifier:
NCT00698763.
AD - Department of Cardiology, Helsinki University Central Hospital, Helsinki,
Finland ; Orion Pharma, Espoo, Finland.
Orion Pharma, Espoo, Finland.
Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
Department of Biosciences, Division of Physiology and Neurosciences, University of
Helsinki, Helsinki Finland.
Division of Clinical Neurosciences, Turku University Hospital, Turku, Finland.
AN - 26082815
AU - Kivikko, M.
AU - Kuoppamäki, M.
AU - Soinne, L.
AU - Sundberg, S.
AU - Pohjanjousi, P.
AU - Ellmen, J.
AU - Roine, R. O.
C2 - PMC4461857
DA - Dec
DO - 10.1016/j.curtheres.2015.01.001
DP - NLM
ET - 2015/06/18
J2 - Current therapeutic research, clinical and experimental
KW - Tia
ambulatory ECG
cerebral blood flow
levosimendan
stroke
LA - eng
N1 - 1879-0313
Kivikko, Matti
Kuoppamäki, Mikko
Soinne, Lauri
Sundberg, Stig
Pohjanjousi, Pasi
Ellmen, Juha
Roine, Risto O
Journal Article
Curr Ther Res Clin Exp. 2015 Jan 29;77:46-51. doi: 10.1016/j.curtheres.2015.01.001.
eCollection 2015 Dec.
PY - 2015
SN - 0011-393X (Print)
0011-393x
SP - 46-51
ST - Oral Levosimendan Increases Cerebral Blood Flow Velocities in Patients with a
History of Stroke or Transient Ischemic Attack: A Pilot Safety Study
T2 - Curr Ther Res Clin Exp
TI - Oral Levosimendan Increases Cerebral Blood Flow Velocities in Patients with a
History of Stroke or Transient Ischemic Attack: A Pilot Safety Study
VL - 77
ID - 3069
ER -
TY - JOUR
AB - The Losartan Intervention For Endpoint reduction in hypertension (LIFE) study
showed that treatment with the angiotensin II type-1 receptor antagonist losartan
reduces overall stroke risk compared with conventional therapy with the beta-
blocker atenolol. We conducted secondary analyses in LIFE to determine the extent
to which the cerebrovascular benefits of losartan apply to different clinical
subgroups and stroke subtypes and to assess the dependence of these benefits on
baseline and time-varying covariates. Among 9193 hypertensive patients with
electrocardiographic evidence of left ventricular hypertrophy, random allocation to
losartan-based treatment lowered the risk of fatal (hazard ratio [HR], 0.65; 95%
confidence interval [CI], 0.43 to 0.96; P=0.032) and atherothrombotic stroke (HR,
0.72; 95% CI, 0.59 to 0.88; P=0.001) compared with atenolol-based therapy. Although
comparable risk reductions occurred for hemorrhagic and embolic stroke, these were
not statistically significant. The number of neurological deficits per stroke was
similar, but there were fewer strokes in the losartan group for nearly every level
of stroke severity. Effects were consistent in all clinical subgroups except for
those defined by age and ethnicity. The benefits of losartan on all strokes were
independent of baseline and time-varying risk factors, including blood pressure.
The number needed to treat for 5 years to prevent 1 stroke was 54 for the average
participant, declining to 25, 24, and 9 for patients with cerebrovascular disease,
isolated systolic hypertension, and atrial fibrillation, respectively. In
conclusion, substantial cerebrovascular benefit could be realized with the
institution of losartan-based therapy over conventional therapy among hypertensive
patients with left ventricular hypertrophy across the spectrum of cardiovascular
risk.
AD - Weill Medical College of Cornell University, New York, NY, USA.
jok2007@med.cornell.edu
AN - 15583076
AU - Kizer, J. R.
AU - Dahlöf, B.
AU - Julius, S.
AU - Beevers, G.
AU - de Faire, U.
AU - Fyhrquist, F.
AU - Ibsen, H.
AU - Kristianson, K.
AU - Lederballe-Pedersen, O.
AU - Lindholm, L. H.
AU - Nieminen, M. S.
AU - Omvik, P.
AU - Oparil, S.
AU - Wedel, H.
AU - Wachtell, K.
AU - Edelman, J. M.
AU - Snapinn, S. M.
AU - Harris, K. E.
DA - Jan
DO - 10.1161/01.HYP.0000151324.05355.1c
DP - NLM
ET - 2004/12/08
IS - 1
J2 - Hypertension (Dallas, Tex. : 1979)
KW - Aged
Aged, 80 and over
Angiotensin II Type 1 Receptor Blockers/*therapeutic use
Antihypertensive Agents/*therapeutic use
Comorbidity
Double-Blind Method
Female
Humans
Hypercholesterolemia/complications
Hypertension/*complications/drug therapy
Hypertrophy, Left Ventricular/*complications
Incidence
Male
Middle Aged
Stroke/epidemiology/*prevention & control
Treatment Outcome
LA - eng
N1 - 1524-4563
Kizer, Jorge R
Dahlöf, Björn
Kjeldsen, Sverre E
Julius, Stevo
Beevers, Gareth
de Faire, Ulf
Fyhrquist, Frej
Ibsen, Hans
Kristianson, Krister
Lederballe-Pedersen, Ole
Lindholm, Lars H
Nieminen, Markku S
Omvik, Per
Oparil, Suzanne
Wedel, Hans
Wachtell, Kristian
Edelman, Jonathan M
Snapinn, Steven M
Harris, Katherine E
Devereux, Richard B
Clinical Trial
Comparative Study
Journal Article
Multicenter Study
United States
Hypertension. 2005 Jan;45(1):46-52. doi: 10.1161/01.HYP.0000151324.05355.1c. Epub
2004 Dec 6.
PY - 2005
SN - 0194-911x
SP - 46-52
ST - Stroke reduction in hypertensive adults with cardiac hypertrophy randomized
to losartan versus atenolol: the Losartan Intervention For Endpoint reduction in
hypertension study
T2 - Hypertension
TI - Stroke reduction in hypertensive adults with cardiac hypertrophy randomized
to losartan versus atenolol: the Losartan Intervention For Endpoint reduction in
hypertension study
VL - 45
ID - 2574
ER -
TY - JOUR
AB - BACKGROUND: Both left bundle branch block and right bundle branch block
(RBBB) have been associated with increased inhospital and long-term mortality in
patients with acute ST elevation myocardial infarction (STEMI). However, the
prognostic role of RBBB in acute non-ST elevation myocardial infarction (NSTEMI) is
not well known. Therefore, the aim of the study was to evaluate the incidence and
clinical impact of RBBB in patients with NSTEMI compared to patients with STEMI.
METHODS: From the German prospective multicenter registry "Maximal Individual
Therapy of Acute Myocardial Infarction" (MITRA PLUS), 6,403 consecutive patients
with NSTEMI and 20,233 patients with STEMI were analyzed. Patients with left bundle
branch block were excluded. The median follow-up time for NSTEMI was 378 days and
for STEMI 479 days. RESULTS: A total of 455 (7.1%) patients with NSTEMI and 894
(4.4%) patients with STEMI presented with RBBB on admission. In general, RBBB
patients were older, more often had comorbidities, and less often received short-
term inhospital treatment according to guidelines. In STEMI, RBBB patients had
higher peak enzyme levels and lower left ventricular ejection fraction (LV-EF) than
patients without BBB. Right bundle branch block in STEMI was associated with an
increased inhospital and long-term mortality. In NSTEMI, however, peak enzyme
levels and LV-EF were similar in both groups with and without RBBB. Right bundle
branch block in NSTEMI was not independently associated with a worse outcome.
CONCLUSIONS: Unlike RBBB in STEMI, RBBB in NSTEMI is not an independent predictor
of inhospital and long-term mortality.
AD - Herzzentrum Ludwigshafen, Institut für Herzinfarktforschung Ludwigshafen an
der Universität Heidelberg, Ludwigshafen, Germany. kleemann.thomas@web.de
AN - 18657654
AU - Kleemann, T.
AU - Juenger, C.
AU - Gitt, A. K.
AU - Schiele, R.
AU - Schneider, S.
AU - Senges, J.
AU - Darius, H.
AU - Seidl, K.
DA - Aug
DO - 10.1016/j.ahj.2008.03.003
DP - NLM
ET - 2008/07/29
IS - 2
KW - Age Factors
Aged
Aged, 80 and over
Bundle-Branch Block/epidemiology/*etiology
Comorbidity
Electrocardiography
Female
Follow-Up Studies
Hospital Mortality
Humans
Incidence
Male
Middle Aged
Myocardial Infarction/classification/*complications/mortality/physiopathology
Observation
Prognosis
Stroke/etiology
Stroke Volume
LA - eng
N1 - 1097-6744
Kleemann, Thomas
Juenger, Claus
Gitt, Anselm Kai
Schiele, Rudolf
Schneider, Steffen
Senges, Jochen
Darius, Harald
Seidl, Karlheinz
MITRA PLUS Study Group
Comparative Study
Journal Article
Multicenter Study
United States
Am Heart J. 2008 Aug;156(2):256-61. doi: 10.1016/j.ahj.2008.03.003. Epub 2008 Jun
20.
PY - 2008
SN - 0002-8703
SP - 256-61
ST - Incidence and clinical impact of right bundle branch block in patients with
acute myocardial infarction: ST elevation myocardial infarction versus non-ST
elevation myocardial infarction
T2 - Am Heart J
TI - Incidence and clinical impact of right bundle branch block in patients with
acute myocardial infarction: ST elevation myocardial infarction versus non-ST
elevation myocardial infarction
VL - 156
ID - 2406
ER -
TY - JOUR
AB - BACKGROUND: To compare in atrial fibrillation patients with and without
diabetes, (1) baseline characteristics, (2) additional risk factors for stroke or
peripheric or visceral embolism (hypertension, previous stroke, age >75 years), (3)
mortality, (4) stroke or embolism, and (5) oral anticoagulation in the year 2000.
METHODS: Included were 409 outpatients with nonrheumatic atrial fibrillation (62
+/- 12 years, 36% female). All underwent transthoracic and transesophageal
echocardiography. Patients with thrombi received oral anticoagulation; patients
without thrombi received aspirin until the follow-up in 1995; afterwards, oral
anticoagulation according to risk factors for stroke or embolism was recommended.
Patients were contacted during the year 2000. RESULTS: Type 2 diabetes was
diagnosed in 73 patients (18%). Sixteen (22%) diabetic and 169 (50%) nondiabetic
patients had no other risk factors for stroke or embolism (p < 0.0001). Diabetic
patients were older, had more frequent heart failure, hypertension, myocardial
infarction, left ventricular dysfunction, valvular abnormalities, left atrial or
appendage thrombi, larger left atria, and left atrial appendages than nondiabetic
patients. Mean follow-up was 115 months. Diabetic patients had a higher mortality
than nondiabetic patients (7%/year versus 4%/year, p < 0.0001). The rate of stroke
or embolism of diabetic (3%/year) and nondiabetic patients (2%/year) was similar.
The rate of oral anticoagulation was higher in diabetic than in nondiabetic
patients (p = 0.0066). CONCLUSIONS: Diabetic patients with atrial fibrillation
frequently have additional risk factors for stroke or embolism, and thus should be
treated with oral anticoagulation. Whether in the rare cases of atrial
fibrillation, in whom diabetes is the only clinical risk factor, oral
anticoagulation is indicated cannot be answered by the present study.
AD - 2nd Medical Department, KA Rudolfstiftung, Juchgasse, Wien, Osterreich.
AN - 12879410
AU - Klem, I.
AU - Wehinger, C.
AU - Schneider, B.
AU - Hartl, E.
AU - Finsterer, J.
DA - Jul-Aug
DO - 10.1002/dmrr.386
DP - NLM
ET - 2003/07/25
IS - 4
J2 - Diabetes/metabolism research and reviews
KW - Aged
Atrial Fibrillation/diagnostic imaging/*epidemiology/*mortality
Austria/epidemiology
Diabetic Angiopathies/diagnostic imaging/*epidemiology/mortality
Echocardiography
Female
Follow-Up Studies
Humans
Intracranial Embolism/epidemiology/prevention & control
Male
Middle Aged
Patient Selection
Reference Values
Risk Factors
Time Factors
LA - eng
N1 - Klem, Igor
Wehinger, Cornelius
Schneider, Barbara
Hartl, Elisabeth
Finsterer, Josef
Comparative Study
Journal Article
England
Diabetes Metab Res Rev. 2003 Jul-Aug;19(4):320-8. doi: 10.1002/dmrr.386.
PY - 2003
SN - 1520-7552 (Print)
1520-7552
SP - 320-8
ST - Diabetic atrial fibrillation patients: mortality and risk for stroke or
embolism during a 10-year follow-up
T2 - Diabetes Metab Res Rev
TI - Diabetic atrial fibrillation patients: mortality and risk for stroke or
embolism during a 10-year follow-up
VL - 19
ID - 2371
ER -
TY - JOUR
AB - BACKGROUND: Atrial fibrillation (AF) is a common complication after
cardiothoracic surgery (CTS). The role of amiodarone added to beta blocker as a
preventive strategy in elderly patients undergoing CTS is not known. The Atrial
Fibrillation Suppression Trial (AFIST) was a double blind, placebo-controlled trial
that evaluated the efficacy of oral amiodarone in patients 60 years or older
undergoing CTS. Beta blockers were administered as part of a critical pathway.
METHODS: Elderly patients (n = 220, mean age 72 +/- 6.7 years) received amiodarone
(n = 120) or placebo (n = 100). Patients enrolled less than 5 days before CTS
received 6 g of drug over 6 days beginning on the day prior to OHS. Patients
enrolled 5 days before CTS received 7 g of study drug over 9-10 days, starting on
preoperative day 4 or 5. RESULTS: Amiodarone treated patients had a lower incidence
of AF (22.5% vs. 38%, p = 0.01), symptomatic AF (4.2% vs. 18%, p = 0.001), cerebral
vascular accident (1.7 vs. 7.0%, p = 0.04), and ventricular tachycardia (1.7% vs.
7.0%, p = 0.04) vs. placebo. Beta blocker use (87.5% vs. 91.0% ), nausea (26.7% vs.
16%, p = 0.056), symptomatic bradycardia (7.5% vs. 7%, p = 0.89), hypotension
(14.2% vs. 10.0%) and 30 day mortality (3.3 vs. 4.0%, p = 0.79) were similar.
Amiodarone treated patients receiving the 4/5 day preoperative regimen had a
reduced incidence of AF (19.6% vs. 38%, p = 0.013), while those receiving the 1-day
preoperative regimen showed a trend (25% vs. 38%, p = 0.06) vs. placebo.
CONCLUSIONS: In an elderly population undergoing CTS, Amiodarone prophylaxis
reduces AF, the incidence of symptomatic AF, cerebrovascular accident and
ventricular tachycardia.
AD - Divisions of Cardiology and Drug Information, Hartford Hospital, 80 Seymour
Street, Hartford, CT, USA. jkluger@harthosp.org
AN - 14618044
AU - Kluger, J.
AU - White, C. M.
DA - Jun
DO - 10.1023/a:1027471718630
DP - NLM
ET - 2003/11/18
IS - 2
J2 - Cardiac electrophysiology review
Adrenergic beta-Antagonists/therapeutic use
Aged
Amiodarone/administration & dosage/*therapeutic use
Anti-Arrhythmia Agents/administration & dosage/*therapeutic use
Atrial Fibrillation/epidemiology/*prevention & control
Double-Blind Method
Humans
Incidence
Postoperative Complications/epidemiology/*prevention & control
Risk Factors
Stroke/epidemiology/*prevention & control
Tachycardia, Ventricular/epidemiology/*prevention & control
Treatment Outcome
LA - eng
N1 - Kluger, Jeffrey
White, C Michael
Clinical Trial
Comparative Study
Journal Article
United States
Card Electrophysiol Rev. 2003 Jun;7(2):165-7. doi: 10.1023/a:1027471718630.
PY - 2003
SN - 1385-2264 (Print)
1385-2264
SP - 165-7
ST - Amiodarone prevents symptomatic atrial fibrillation and reduces the risk of
cerebrovascular accidents and ventricular tachycardia after open heart surgery:
results of the Atrial Fibrillation Suppression Trial (AFIST)
T2 - Card Electrophysiol Rev
TI - Amiodarone prevents symptomatic atrial fibrillation and reduces the risk of
cerebrovascular accidents and ventricular tachycardia after open heart surgery:
results of the Atrial Fibrillation Suppression Trial (AFIST)
VL - 7
ID - 2527
ER -
TY - JOUR
AB - Primary percutaneous coronary intervention (PCI) is the preferred reperfusion
strategy for ST-elevation acute myocardial infarction (STEMI). In comatose
survivors of cardiac arrest, mild induced hypothermia (MIH) improves neurological
recovery. In the present study, we investigated feasibility and safety of combining
primary PCI and MIH in comatose survivors of ventricular fibrillation with signs of
STEMI after reestablishment of spontaneous circulation. Forty consecutive patients
undergoing primary PCI and MIH from November 1, 2003 to December 31, 2005 were
compared to 32 consecutive patients who underwent primary PCI but no MIH between
January 1, 2000 and November 1, 2003. There were no significant differences between
the MIH and no MIH groups in general characteristics, cardiac arrest circumstances
and angiographic features. Except for decreases in heart rate during hypothermia
interval, there was no difference between the MIH and no MIH groups in arterial
pressure, peak arterial lactate (5.1 mmol/l versus 5.7 mmol/l; p = .56), need for
vasopressors (65% versus 53%; p = .44), inotropes (48% versus 59%; p = .44), aortic
balloon counterpulsation (20% versus 22%; p = .92), repeat
cardioversion/defibrillation (30% versus 34%; p=.89) and use of antiarrhythmics
(33% versus 53%; p = .13). There was also no difference in inspired oxygen
requirements during mechanical ventilation and in renal function. Hospital survival
with cerebral performance category 1 and 2 was significantly better in MIH group
(55% versus 16%; p=.001). Our preliminary experience indicates that primary PCI and
MIH are feasible and may be combined safely in comatose survivors of ventricular
fibrillation with signs of STEMI. Such a strategy may improve survival with good
neurological recovery.
AD - Center for Intensive Internal Medicine, University Medical Center, Zaloska 7,
1000 Ljubljana, Slovenia.
AN - 17383070
AU - Knafelj, R.
AU - Radsel, P.
AU - Ploj, T.
AU - Noc, M.
DA - Aug
DP - NLM
ET - 2007/03/27
IS - 2
J2 - Resuscitation
KW - *Angioplasty, Balloon, Coronary
Coma/*physiopathology
Feasibility Studies
Female
Humans
Male
Middle Aged
Myocardial Infarction/physiopathology/*therapy
Risk Factors
Treatment Outcome
LA - eng
N1 - Knafelj, Rihard
Radsel, Peter
Ploj, Tom
Noc, Marko
Journal Article
Ireland
Resuscitation. 2007 Aug;74(2):227-34. doi: 10.1016/j.resuscitation.2007.01.016.
Epub 2007 Mar 23.
PY - 2007
SN - 0300-9572 (Print)
0300-9572
SP - 227-34
ST - Primary percutaneous coronary intervention and mild induced hypothermia in
comatose survivors of ventricular fibrillation with ST-elevation acute myocardial
infarction
T2 - Resuscitation
TI - Primary percutaneous coronary intervention and mild induced hypothermia in
comatose survivors of ventricular fibrillation with ST-elevation acute myocardial
infarction
VL - 74
ID - 2971
ER -
TY - JOUR
AB - BACKGROUND: During the past 15 years, closure of a secundum atrial septal
defect (ASD) has moved from a surgical to a percutaneous transcatheter approach.
Few long-term studies of the efficacy and safety of closure of an ASD by an
Amplatzer septal occluder (ASO) exist. METHODS: To examine the long-term results of
secundum ASD closure using the ASO, data on 94 patients who underwent secundum ASD
closure with the ASO between 1998 and 2002 were available and reviewed. Data
regarding residual shunt, chest pain, palpitations, arrhythmias, headaches,
transient ischemic attacks, cerebrovascular accidents, and mortality were
collected. RESULTS: Seven (7.4%) subjects had residual shunts immediately following
ASO placement. During follow-up, 4 residual shunts closed for a complete closure
rate of 97%. Eighteen (19%) patients reported chest pain during the follow-up
period. Twenty-three patients (24%) reported palpitations during the follow up
period, 7 were documented arrhythmias, including supraventricular tachycardia,
atrial fibrillation, and premature ventricular beats. Migraine headaches were new-
onset in 4 patients. Migraine cessation occurred in 2 patients after secundum ASD
closure. One child died from a cerebral vascular event 18 months following device
placement. Only 1 patient developed mild aortic insufficiency. CONCLUSION: These
data indicate that for up to 120 months of patient follow-up, the ASO continues to
be a safe device. Residual shunts and arrhythmias have low incidence post-ASO
placement. Given the mortality in one high-risk patient, further investigation into
anti-platelet therapy after device placement is warranted.
AD - University of Michigan Congenital Heart Center-Department of Pediatrics, Ann
Arbor, MI 48109, USA. mknepp@umich.edu
AN - 20136855
AU - Knepp, M. D.
AU - Rocchini, A. P.
AU - Lloyd, T. R.
AU - Aiyagari, R. M.
DA - Jan-Feb
DO - 10.1111/j.1747-0803.2009.00358.x
DP - NLM
ET - 2010/02/09
IS - 1
J2 - Congenital heart disease
KW - Adult
Cardiac Catheterization/adverse effects/*instrumentation/mortality
Chest Pain/etiology
Child
Child, Preschool
Headache/etiology
Heart Septal Defects, Atrial/mortality/*therapy
Humans
Middle Aged
*Septal Occluder Device
Stroke/etiology
Time Factors
Treatment Outcome
LA - eng
N1 - 1747-0803
Knepp, Marc D
Rocchini, Albert P
Lloyd, Thomas R
Aiyagari, Ranjit M
Journal Article
United States
Congenit Heart Dis. 2010 Jan-Feb;5(1):32-7. doi: 10.1111/j.1747-0803.2009.00358.x.
PY - 2010
SN - 1747-079x
SP - 32-7
ST - Long-term follow up of secundum atrial septal defect closure with the
amplatzer septal occluder
T2 - Congenit Heart Dis
TI - Long-term follow up of secundum atrial septal defect closure with the
amplatzer septal occluder
VL - 5
ID - 2696
ER -
TY - JOUR
AB - Profound hypothermia (core temperature of less than 28 degrees C) is a life
threatening state and a medical emergency associated with a high mortality rate.
The prognosis depends on underlying diseases, advanced or very early age, the
duration prior to treatment, the degree of hemodynamic deterioration, and
especially, the methods of treatment, including active external or internal
rewarming. This is a case study of an 80-year-old female patient with severe
accidental hypothermia (core temperature 27 degrees C). She was found in her home
lying immobile on the cold floor after a fall. The patient was in a profound coma
with cardiocirculatory collapse, and the medical staff treating her was inclined to
pronounce her deceased. On her arrival at the hospital, she was resuscitated, put
on a respirator and actively warmed. Very severe metabolic disorders were found,
including a marked metabolic acidosis composed of diabetic ketoacidosis (she had
suffered from insulin treated type 2 diabetes mellitus) and lactic acidosis with a
very high anion gap (42) and a hyperosmotic state (blood glucose 1202 mg/dl). There
were pathognomonic electrocardiographic abnormalities, J-wave of Osborn and
prolonged repolarization. Slow atrial fibrillation with a ventricular response of
30 bpm followed by a nodal rhythm of 12 bpm and reversible cardiac arrest were
recorded. The pulse and blood pressure were unobtainable. Despite the successful
resuscitation and hemodynamic and cognitive improvement, rhabdomyolysis (CKP 6580
u/L), renal failure and hepatic damage developed. She was extubated and treated
with intravenous fluids containing dopamine, bicarbonate, insulin and antibiotics.
Her medical condition gradually improved, and she was discharged clear minded,
functioning very well and independent. Renal and liver tests returned eventually to
normal limits. Progressive bradycardia, hypotension and death due to ventricular
fibrillation or asystole commonly occur during severe hypothermia. Respiratory and
metabolic, sometimes lactic, acidosis, lethargy and coma, hypercoagulopathy,
hyperosmolar state, acute pancreatitis and renal and hepatic failure are frequent
complications of hypothermia. Underlying predisposing causes of hypothermia are
diabetic ketoacidosis, cerebrovascular disease, mental retardation, hypothyroidism,
pituitary and adrenal insufficiency, malnutrition, acute alcoholism, liver damage,
hypoglycemia, sepsis, hypothalamic dysfunction, sepsis and polypharmacy, and
especially, the use of sedative and narcotic drugs. Our case demonstrates once
again that CPR once begun should continue until the successful rewarming because
"no one is dead until warm and dead".
AD - Department of Medicine B, Edith Wolfson Medical Center, Holon.
AN - 11759373
AU - Knobel, B.
AU - Mikhlin, A.
DA - Nov
DP - NLM
ET - 2002/01/05
IS - 11
J2 - Harefuah
KW - Aged
Aged, 80 and over
Atrial Fibrillation/diagnosis
Body Temperature
Coma
Diabetic Ketoacidosis/diagnosis
Female
Fluid Therapy
Humans
Hypothermia/*physiopathology
Resuscitation
Treatment Outcome
LA - heb
N1 - Knobel, B
Mikhlin, A
Case Reports
English Abstract
Journal Article
Israel
Harefuah. 2001 Nov;140(11):1014-7, 1119.
PY - 2001
SN - 0017-7768 (Print)
0017-7768
SP - 1014-7, 1119
ST - [Severe accidental hypothermia in an elderly woman]
T2 - Harefuah
TI - [Severe accidental hypothermia in an elderly woman]
VL - 140
ID - 3021
ER -
TY - JOUR
AB - Peripartum cardiomyopathy is a rare cardiac disorder. Although left
ventricular apical thrombus formation is common in peripartum cardiomyopathy,
biventricular apical thrombi formation is a very rare condition in these patients.
A 21-year-old woman presented with complaints of dyspnea, orthopnea, paroxysmal
nocturnal dyspnea, and palpitations that appeared three months after labor.
Transthoracic echocardiography showed severe global hypokinesis, decreased left and
right ventricular ejection fraction (left 30%, right 35%), increased left
ventricular end-diastolic dimension (60 mm), grade 2 mitral regurgitation, and
biventricular apical thrombi. On the second day of admission, she developed global
aphasia and right hemiplegia. The patient was successfully treated with recombinant
tissue plasminogen activator. Transthoracic echocardiography following treatment
showed disappearance of biventricular apical thrombi. She had no neurologic
deficit. Treatment for heart failure was continued due to persistence of global
hypokinesis and left ventricular dilatation.
AD - Department of Cardiology, Adana Numune Training and Research Hospital, Adana,
Turkey. mevlutkoc78@yahoo.com
AN - 21983772
AU - Koç, M.
AU - Sahin, D. Y.
AU - Tekin, K.
AU - Caylı, M.
DA - Oct
DO - 10.5543/tkda.2011.01534
DP - NLM
ET - 2011/10/11
IS - 7
J2 - Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir
KW - Cardiomyopathies/*diagnosis/diagnostic imaging/drug therapy
Dyspnea
Female
Heart Atria
Humans
Intracranial Embolism/*diagnosis/drug therapy
Puerperal Disorders/*diagnosis/diagnostic imaging/drug therapy
Tachycardia
Thrombosis/*diagnosis/diagnostic imaging/drug therapy
Tissue Plasminogen Activator/therapeutic use
Young Adult
LA - tur
N1 - Koç, Mevlüt
Sahin, Durmuş Yıldıray
Tekin, Kamuran
Caylı, Murat
Journal Article
Turkey
Turk Kardiyol Dern Ars. 2011 Oct;39(7):591-4. doi: 10.5543/tkda.2011.01534.
OP - Doğum dönemi kardiyomiyopatisi olan genç bir hastada her iki ventrikülde
geniş apikal trombüs ve serebral emboli gelişimi.
PY - 2011
SN - 1016-5169 (Print)
1016-5169
SP - 591-4
ST - [Development of biventricular large apical thrombi and cerebral embolism in a
young woman with peripartum cardiomyopathy]
T2 - Turk Kardiyol Dern Ars
TI - [Development of biventricular large apical thrombi and cerebral embolism in a
young woman with peripartum cardiomyopathy]
VL - 39
ID - 3024
ER -
TY - JOUR
AB - A previously well 40-year-old woman suddenly collapsed and had to be
resuscitated by an emergency physician. Admitted to hospital she remained
unconscious and needed artificial respiration. Diagnostic tests failed to find
evidence for pulmonary embolism, myocardial infarction or myocarditis. ECG
monitoring in the intensive care unit merely revealed occasional unifocal
ventricular premature systoles. Echocardiography was within normal limits. She
remained in coma without spontaneous respiration. Cranial computed tomography and
serial electroencephalograms indicated brain death. Autopsy revealed lipomatous
hypertrophy (hamartoma) of the atrial septum with extensive bleeding into it as the
most likely cause of (unrecorded) malignant cardiac arrhythmias.
AD - Medizinische Poliklinik, Universität Marburg.
AN - 1889355
AU - Koehler, U.
AU - Bittinger, A.
DA - Sep 13
DO - 10.1055/s-2008-1063763
DP - NLM
ET - 1991/09/13
IS - 37
KW - Adult
Arrhythmias, Cardiac/diagnosis/etiology/pathology
Emergencies
Female
Hamartoma/*complications/diagnosis/pathology
Heart Neoplasms/*complications/diagnosis/pathology
Heart Septum/*pathology
Humans
Hypertrophy/complications/diagnosis/pathology
Lipoma/*complications/diagnosis/pathology
Neoplasms, Multiple Primary/*complications/diagnosis/pathology
Syncope/diagnosis/*etiology/pathology
LA - ger
N1 - Koehler, U
Bittinger, A
Case Reports
English Abstract
Journal Article
Germany
Dtsch Med Wochenschr. 1991 Sep 13;116(37):1393-6. doi: 10.1055/s-2008-1063763.
OP - Lipomatöse Hypertrophie des Vorhofseptums. Kardial bedingte Synkope bei
Hamartom des rechten Herzvorhofs.
PY - 1991
SN - 0012-0472 (Print)
0012-0472
SP - 1393-6
ST - [Lipomatous hypertrophy of the atrial septum. Cardiac-induced syncope in
hamartoma of the right heart atrium]
TI - [Lipomatous hypertrophy of the atrial septum. Cardiac-induced syncope in
hamartoma of the right heart atrium]
VL - 116
ID - 2828
ER -
TY - JOUR
AB - Posthypoxic coma is often associated with cortical and brainstem
hyperexcitability. Five months following cardiopulmonary resuscitation after
myocardial infarction and ventricular arrhythmia, a 47-year-old man presented with
posthypoxic cerebral dysfunction, minimal responsiveness, severe spastic-dystonic
tetraparesis, and stimulus-sensitive muscle spasms upon acoustic and sensory
stimulation. Neurophysiological examination revealed increased long-loop reflexes
in abductor pollicis brevis muscle following median nerve stimulation at the wrist,
consistent with cortical hyperexcitability. Exaggerated startle responses provided
evidence of concomitant brainstem disinhibition. Levetiracetam up to 3,000 mg per
day suppressed transcortical long-loop reflexes in a dose-dependent manner without
concomitant suppression of the H-reflex and only mild attenuation of the startle
response. The present findings suggest a suppressive effect of levetiracetam on
cortical neurons in the absence of a spinal effect on monosynaptic reflexes, and
thus support the drug's efficacy in posthypoxic cortical hyperexcitability.
AD - Department of Neurology, Hospital Hochzirl, A-6170 Zirl, Austria.
markus.kofler@uibk.ac.at
AN - 16518861
AU - Kofler, M.
DA - Jun
DO - 10.1002/mus.20533
DP - NLM
ET - 2006/03/07
IS - 6
J2 - Muscle & nerve
KW - Coma/*drug therapy/physiopathology
Evoked Potentials, Somatosensory/drug effects
H-Reflex/drug effects
Humans
Hypoxia, Brain/*drug therapy/physiopathology
Levetiracetam
Male
Middle Aged
Nootropic Agents/*therapeutic use
Piracetam/*analogs & derivatives/therapeutic use
Reflex, Startle/drug effects
Somatosensory Cortex/*drug effects
LA - eng
N1 - Kofler, Markus
Case Reports
Journal Article
United States
Muscle Nerve. 2006 Jun;33(6):785-91. doi: 10.1002/mus.20533.
PY - 2006
SN - 0148-639X (Print)
0148-639x
SP - 785-91
ST - Levetiracetam suppresses long-loop reflexes at the cortical level
T2 - Muscle Nerve
TI - Levetiracetam suppresses long-loop reflexes at the cortical level
VL - 33
ID - 3086
ER -
TY - JOUR
AB - One hundred thirty-six patients with hypertrophic cardiomyopathy were
followed up for 1 to 17 years. Twenty-one patients had died, 14 of them suddenly,
two from heart failure, two from cerebral embolism, and three from noncardiac
causes. Life table analysis revealed that sudden death was significantly associated
with young age less than 20 years (relative risk [rr] = 8.63, when compared with
those greater than 40 years) and with positive Master's single two-step test (rr =
3.55). Heart failure was more frequent in patients with positive Master's single
test (rr = 4.27) and with left ventricular end-diastolic pressure greater than 20
mm Hg (rr = 2.58). Atrial fibrillation, observed in 15 patients, was a poor
prognostic sign, resulting in five cardiac deaths and seven heart failures. In
contrast, prognosis was favorable in patients with apical hypertrophy with giant
negative T wave. Thus Japanese patients with hypertrophic cardiomyopathy showed a
prognosis consistent with Western patients, except for excellent outcome of apical
hypertrophy.
AN - 6540514
AU - Koga, Y.
AU - Itaya, K.
AU - Toshima, H.
DA - Aug
DO - 10.1016/0002-8703(84)90624-0
DP - NLM
ET - 1984/08/01
IS - 2
KW - Adult
Aged
Atrial Fibrillation/etiology/physiopathology
Blood Pressure
Cardiomyopathy, Hypertrophic/*complications/mortality/physiopathology
Death, Sudden/*etiology
Electrocardiography
Female
Follow-Up Studies
Heart Failure/etiology/physiopathology
Humans
Male
Middle Aged
Prognosis
Risk
LA - eng
N1 - Koga, Y
Itaya, K
Toshima, H
Journal Article
United States
Am Heart J. 1984 Aug;108(2):351-9. doi: 10.1016/0002-8703(84)90624-0.
PY - 1984
SN - 0002-8703 (Print)
0002-8703
SP - 351-9
ST - Prognosis in hypertrophic cardiomyopathy
T2 - Am Heart J
TI - Prognosis in hypertrophic cardiomyopathy
VL - 108
ID - 2968
ER -
TY - JOUR
AB - BACKGROUND: Periprocedural anticoagulation is important in catheter ablation
(CA) of atrial fibrillation (AF) and there is increasing evidence that
uninterrupted vitamin K antagonist (VKA) therapy is superior to interrupted
anticoagulation strategies. Since the emergence of direct oral anticoagulants
(DOACs), numerous studies have shown promising results for their use in
uninterrupted strategies. However, further studies are needed to further define the
efficacy and safety of performing AF ablation with uninterrupted factor XA
inhibitors or direct thrombin inhibitors.Methods and Results:We have performed CA
of AF without discontinuation of either VKA or DOAC therapy since April 2014. A
total of 376 patients with AF underwent CA including pulmonary vein isolation. All
of the patients were divided into 2 groups (uninterrupted VKA or uninterrupted
DOACs). Anticoagulation with DOACs was associated with fewer complications than
uninterrupted VKA therapy (P=0.04). There were significant differences between
groups in the rates of congestive heart failure, left ventricular ejection
fraction, body weight, and estimated glomerular filtration rate and of the
CHADS(2), CHA(2)DS(2)-VASc and HAS-BLED scores. Therefore, we also analyzed the
results using the propensity score-matching method. We found no significant
difference in periprocedural complications between uninterrupted VKA or DOACs
therapy (P=0.65). CONCLUSIONS: CA of AF without discontinuation of DOACs is not
inferior to CA without discontinuation of a VKA, with regard to ischemic or
hemorrhagic complications.
AD - Department of Cardiovascular Medicine, The University of Tokyo.
Department of Ubiquitous Health Informatics, The University of Tokyo.
Clinical Research Support Center, The University of Tokyo.
AN - 29657252
AU - Kojima, T.
AU - Fujiu, K.
AU - Fukuma, N.
AU - Matsunaga, H.
AU - Oshima, T.
AU - Matsuda, J.
AU - Matsubara, T.
AU - Shimizu, Y.
AU - Oguri, G.
AU - Hasumi, E.
AU - Morita, H.
AU - Komuro, I.
DA - May 25
DO - 10.1253/circj.CJ-17-1114
DP - NLM
ET - 2018/04/17
IS - 6
J2 - Circulation journal : official journal of the Japanese Circulation Society
KW - Aged
Atrial Fibrillation/*therapy
Cardiac Tamponade/etiology
Catheter Ablation/*adverse effects/methods
Female
Hemorrhage/etiology
Humans
Male
Middle Aged
Stroke/etiology
Vitamin K/*antagonists & inhibitors
*Ablation
*Anticoagulants
LA - eng
N1 - 1347-4820
Kojima, Toshiya
Fujiu, Katsuhito
Fukuma, Nobuaki
Matsunaga, Hiroshi
Oshima, Tsukasa
Matsuda, Jun
Matsubara, Takumi
Shimizu, Yu
Oguri, Gaku
Hasumi, Eriko
Morita, Hiroyuki
Komuro, Issei
Journal Article
Observational Study
Japan
Circ J. 2018 May 25;82(6):1552-1557. doi: 10.1253/circj.CJ-17-1114. Epub 2018 Apr
13.
PY - 2018
SN - 1346-9843
SP - 1552-1557
ST - Periprocedural Complications in Patients Undergoing Catheter Ablation of
Atrial Fibrillation Without Discontinuation of a Vitamin K Antagonist and Direct
Oral Anticoagulants
T2 - Circ J
TI - Periprocedural Complications in Patients Undergoing Catheter Ablation of
Atrial Fibrillation Without Discontinuation of a Vitamin K Antagonist and Direct
Oral Anticoagulants
VL - 82
ID - 2445
ER -
TY - JOUR
AN - 14069280
AU - Kolesnikoz, S. A.
AU - Tsukerman, G. I.
AU - Leonteva, N. S.
AU - Meitina, R. A.
AU - IuS, Petrosian
AU - Golia, B. F.
AU - Astrakhantseva, G. I.
DA - Jun
DP - NLM
ET - 1963/06/01
J2 - Sovetskaia meditsina
KW - *Cardiac Surgical Procedures
*Heart Failure
Humans
*Hypertension
*Hypertension, Pulmonary
*Hypoxia, Brain
*Pulmonary Edema
*Respiratory Insufficiency
*Thoracic Surgery
*cerebral anoxia
*heart failure, congestive
*heart surgery
LA - rus
N1 - Kolesnikoz, s a
Tsukerman, g i
Leonteva, n s
Meitina, r a
PETROSIAN, Iu S
Golia, b f
Astrakhantseva, g i
Journal Article
Russia (Federation)
Sov Med. 1963 Jun;27:14-20.
OP - Osobennosti operatsionnogo i blizha ishego posleoperatsionnogo perioda posle
mitral'no i komissurotomii u bol'nykh s vysoko i legochno i gipertenzie i.
PY - 1963
SN - 0038-5077 (Print)
0038-5077
SP - 14-20
ST - [FEATURES OF THE OPERATIVE AND IMMEDIATED POSTOPERATIVE PERIOD AFTER MITRAL
COMMISSUROTOMY IN PATIENTS WITH SEVERE PULMONARY HYPERTENSION]
T2 - Sov Med
TI - [FEATURES OF THE OPERATIVE AND IMMEDIATED POSTOPERATIVE PERIOD AFTER MITRAL
COMMISSUROTOMY IN PATIENTS WITH SEVERE PULMONARY HYPERTENSION]
VL - 27
ID - 2874
ER -
TY - JOUR
AB - The CHADS(2) score is useful in stratifying the risk of ischemic stroke or
transient ischemic attack (TIA) in patients with non-valvular atrial fibrillation
(AF). However, it remains unclear whether the CHADS(2) score could predict stroke
or TIA in chronic heart failure (CHF) patients without AF. Recently, the new stroke
risk score was proposed from 2 contemporary heart failure trials. We evaluated the
prognostic power of the CHADS(2) score for stroke or TIA in CHF patients without AF
in comparison to the "stroke risk score". We retrospectively studied 127 CHF
patients [left ventricular ejection fraction (LVEF) <40 %] without AF, who had been
enrolled in our previous prospective cohort study. The primary endpoint was the
incidence of stroke or TIA. The mean baseline CHADS(2) score was 2.1 ± 1.0. During
the follow-up period of 8.4 ± 5.1 years, stroke or TIA occurred in 21 of 127
patients. At multivariate Cox analysis, CHADS(2) score (C-index 0.794), but not
"stroke risk score" (C-index 0.625), was significantly and independently associated
with stroke or TIA. The incidence of stroke or TIA appeared to increase in relation
to the CHADS(2) score [low (=1), 0 per 100 person-years; intermediate (=2), 1.6 per
100 person-years; high (≥3), 4.7 per 100 person-years; p = 0.04]. CHADS(2) score
could stratify the risk of ischemic stroke in CHF patients with the absence of AF,
with greater prognostic power than the "stroke risk score".
AD - Division of Cardiology, Osaka General Medical Center, 3-1-56 Bandai-Higashi,
Sumiyoshi-ku, Osaka, Japan. takumikondou2000@yahoo.co.jp.
Division of Cardiology, Osaka General Medical Center, 3-1-56 Bandai-Higashi,
Sumiyoshi-ku, Osaka, Japan.
Division of Cardiovascular Medicine, Osaka University Graduate School of Medicine,
AN - 27325225
AU - Kondo, T.
AU - Yamada, T.
AU - Morita, T.
AU - Furukawa, Y.
AU - Tamaki, S.
AU - Iwasaki, Y.
AU - Kawasaki, M.
AU - Kikuchi, A.
AU - Kawai, T.
AU - Takahashi, S.
AU - Ishimi, M.
AU - Hakui, H.
AU - Ozaki, T.
AU - Sato, Y.
AU - Seo, M.
AU - Sakata, Y.
AU - Fukunami, M.
DA - Feb
DO - 10.1007/s00380-016-0861-7
DP - NLM
ET - 2016/06/22
IS - 2
J2 - Heart and vessels
KW - Aged
Female
Follow-Up Studies
Heart Failure/*complications
Humans
Incidence
Ischemic Attack, Transient/*diagnosis/*epidemiology/etiology
Japan
Male
Middle Aged
Prognosis
ROC Curve
Risk Factors
*Severity of Illness Index
Stroke/*diagnosis/*epidemiology/etiology
*CHADS2 score
*Chronic heart failure
*Risk stratification
*Stroke
LA - eng
N1 - 1615-2573
Kondo, Takumi
Orcid: 0000-0001-8475-6240
Yamada, Takahisa
Morita, Takashi
Furukawa, Yoshio
Tamaki, Shunsuke
Iwasaki, Yusuke
Kawasaki, Masato
Kikuchi, Atsushi
Kawai, Tsutomu
Takahashi, Satoshi
Ishimi, Masashi
Hakui, Hideyuki
Ozaki, Tatsuhisa
Sato, Yoshihiro
Seo, Masahiro
Sakata, Yasushi
Fukunami, Masatake
Comparative Study
Journal Article
Japan
Heart Vessels. 2017 Feb;32(2):193-200. doi: 10.1007/s00380-016-0861-7. Epub 2016
Jun 21.
PY - 2017
SN - 0910-8327
SP - 193-200
ST - The CHADS(2) score predicts ischemic stroke in chronic heart failure patients
without atrial fibrillation: comparison to other stroke risk scores
T2 - Heart Vessels
TI - The CHADS(2) score predicts ischemic stroke in chronic heart failure patients
without atrial fibrillation: comparison to other stroke risk scores
VL - 32
ID - 2362
ER -
TY - JOUR
AB - BACKGROUND: Atrial fibrillation (AF) is a common complication of coronary
artery bypass graft (CABG) surgery, occurring in 20%-40% of patients, mostly during
the first week after surgery. It is associated with increased morbidity and
mortality, but data are limited. OBJECTIVES: To assess the correlation between new-
onset in-hospital AF following CABG and long-term AF, cerebrovascular accident
(CVA), or death. METHODS: We conducted an analysis of 161 consecutive patients who
underwent isolated CABG surgery in a tertiary center during the period 2002-2003.
RESULTS: Patients' mean age was 72 years, and the majority were males (77%).
Approximately half of the patients experienced prior myocardial infarction, and 14%
had left ventricular ejection fraction < 40%. Postoperative AF (POAF) occurred in
27% of the patients. Patients were older and had larger left atrium diameter. POAF
was strongly correlated with late AF (OR 4.34, 95%CI 1.44-13.1, P = 0.01) during a
mean follow-up of 8.5 years. It was also correlated with long-term stroke but was
not associated with long-term mortality. CONCLUSIONS: POAF is a common complication
of CABG surgery, which is correlated with late AF and stroke. Patients with POAF
should be closely monitored to facilitate early administration of anticoagulant
therapy in a high risk population upon recurrence of AF.
AD - Department of Cardiology, Soroka University Medical Center.
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Department of Cardiothoracic Surgery, Soroka University Medical Center and Faculty
of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Division of Cardiology, Department of Medicine, McMaster University, Hamilton,
Canada.
AN - 28457078
AU - Konstantino, Y.
AU - Zelnik Yovel, D.
AU - Friger, M. D.
AU - Sahar, G.
AU - Knyazer, B.
AU - Amit, G.
DA - Dec
DP - NLM
ET - 2017/05/01
IS - 12
J2 - The Israel Medical Association journal : IMAJ
KW - Aged
Aged, 80 and over
Atrial Fibrillation/*epidemiology/etiology
Cohort Studies
Coronary Artery Bypass/*adverse effects/methods
Female
Follow-Up Studies
Humans
Male
Postoperative Complications/*epidemiology
Recurrence
Risk Factors
Time Factors
LA - eng
N1 - Konstantino, Yuval
Zelnik Yovel, Dana
Friger, Michael D
Sahar, Gideon
Knyazer, Boris
Amit, Guy
Journal Article
Israel
Isr Med Assoc J. 2016 Dec;18(12):744-748.
PY - 2016
SN - 1565-1088 (Print)
SP - 744-748
ST - Postoperative Atrial Fibrillation Following Coronary Artery Bypass Graft
Surgery Predicts Long-Term Atrial Fibrillation and Stroke
T2 - Isr Med Assoc J
TI - Postoperative Atrial Fibrillation Following Coronary Artery Bypass Graft
Surgery Predicts Long-Term Atrial Fibrillation and Stroke
VL - 18
ID - 2464
ER -
TY - JOUR
AB - Electrocardiographic abnormalities and cardiac arrhythmias are commonly noted
after acute stroke. Risk of malignant ventricular arrhythmias is increased after a
stroke and is associated with sudden cardiac death. Autonomic imbalance modulated
by direct injury to neurogenic structures and enhanced by catecholamine storm can
lead to myocardial damage and arrhythmogenesis. Experimental and clinical evidence
suggests that insular cortex infarcts play a key role in autonomic dysregulation
that lead to arrhythmias in the acute setting. Management of ventricular
arrhythmias associated with acute stroke should focus on continuous cardiac
monitoring, drug therapy, and electrolyte correction. Further research is needed to
identify neurological structures involved in autonomic control and risk factors for
ventricular arrhythmogenesis after acute stroke.
AD - Heart Rhythm Service, Kingston General Hospital, Queen's University,
Kingston, Ontario, Canada.
AN - 23602297
AU - Koppikar, S.
AU - Baranchuk, A.
AU - Guzmán, J. C.
AU - Morillo, C. A.
DA - Sep 30
DO - 10.1016/j.ijcard.2013.03.058
DP - NLM
ET - 2013/04/23
IS - 2
KW - Animals
Humans
Stroke/*diagnosis/*epidemiology/therapy
Tachycardia, Ventricular/*diagnosis/*epidemiology/therapy
Acquired QT prolongation
Autonomic nervous system
Insular cortex
Stroke
Systematic review
Ventricular arrhythmias
LA - eng
N1 - 1874-1754
Koppikar, Sahil
Baranchuk, Adrian
Guzmán, Juan Camilo
Morillo, Carlos A
Journal Article
Review
Systematic Review
Netherlands
Int J Cardiol. 2013 Sep 30;168(2):653-9. doi: 10.1016/j.ijcard.2013.03.058. Epub
2013 Apr 17.
PY - 2013
SN - 0167-5273
SP - 653-9
ST - Stroke and ventricular arrhythmias
T2 - Int J Cardiol
TI - Stroke and ventricular arrhythmias
VL - 168
ID - 2302
ER -
TY - JOUR
AB - BACKGROUND: Thromboembolic complications remain one of the most severe
adverse events associated with catheter ablation of atrial fibrillation (AF), but
data on such events are limited. OBJECTIVE: The purpose of this study was to
evaluate the incidence, characteristics, and risk factors of thromboembolic
complications after AF ablation. METHODS: Cerebral thromboembolic complications
occurring within 1 month of 3360 consecutive AF radiofrequency catheter ablations
were assessed. Stroke was defined as a neurologic deficit lasting more than 24
hours or with imaging study showing new infarction. Transient ischemic attack (TIA)
was defined as a deficit lasting less than 24 hours and without documented
infarction. RESULTS: There were 17 peri-interventional cerebral thromboembolic
events (0.5%). Nine cases (53%) were diagnosed as strokes and 8 (47%) as TIAs.
Sixty percent of the events occurred within 48 hours after the ablation; the rest
occurred within 1 week. In univariate analysis, peri-interventional thromboembolism
was associated with peripheral vascular disease (P = .010), impaired left
ventricular ejection fraction (P = .040), periprocedural bridging with heparin (P =
.007), and previous stroke (P = .026). Multivariable analysis demonstrated that
peripheral vascular disease (odds ratio [OR] 8.81, confidence interval [CI] 1.61-
48.31, P = .012) and previous stroke (OR 6.13, CI 1.18-31.91, P = .031) were
independent predictors. In a different model, the CHA2DS2-VASc score was associated
with thromboembolism (OR 1.35, CI 1.00-1.80, P = .049). CONCLUSION: Cerebral
thromboembolic complications after AF radiofrequency catheter ablation are rare.
They mostly occur within 48 hours after the procedure and remain without lasting
neurologic deficits in the majority of cases. Such complications are associated
with peripheral vascular disease, previous stroke, and the CHA2DS2-VASc score.
AD - Department of Electrophysiology, Heart Center Leipzig, Leipzig, Germany.
Electronic address: jedrzejkosiuk@hotmail.com.
Department of Electrophysiology, Heart Center Leipzig, Leipzig, Germany; University
of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, United
Kingdom.
Department of Electrophysiology, Heart Center Leipzig, Leipzig, Germany.
Department of Electrophysiology, Dresden University-Heart Center, Dresden, Germany.
3rd Department of Cardiology, Department of Cardiovascular Diseases, Silesian
Center for Heart Diseases, Zabrze, Poland.
AN - 25086257
AU - Kosiuk, J.
AU - Kornej, J.
AU - Bollmann, A.
AU - Piorkowski, C.
AU - Myrda, K.
AU - Arya, A.
AU - Sommer, P.
AU - Richter, S.
AU - Rolf, S.
AU - Husser, D.
AU - Gaspar, T.
AU - Lip, G. Y.
AU - Hindricks, G.
DA - Nov
DO - 10.1016/j.hrthm.2014.07.039
DP - NLM
ET - 2014/08/03
IS - 11
J2 - Heart rhythm
KW - Atrial Fibrillation/*surgery
Female
Humans
Incidence
Intracranial Thrombosis/*epidemiology
Male
Middle Aged
Postoperative Complications/*epidemiology
Risk Factors
Atrial fibrillation
Catheter ablation
Complications
Thromboembolism
LA - eng
N1 - 1556-3871
Kosiuk, Jedrzej
Kornej, Jelena
Bollmann, Andreas
Piorkowski, Christopher
Myrda, Krzysztof
Arya, Arash
Sommer, Philipp
Richter, Sergio
Rolf, Sascha
Husser, Daniela
Gaspar, Thomas
Lip, Gregory Y H
Hindricks, Gerhard
Journal Article
United States
Heart Rhythm. 2014 Nov;11(11):1934-40. doi: 10.1016/j.hrthm.2014.07.039. Epub 2014
Jul 30.
PY - 2014
SN - 1547-5271
SP - 1934-40
ST - Early cerebral thromboembolic complications after radiofrequency catheter
ablation of atrial fibrillation: incidence, characteristics, and risk factors
T2 - Heart Rhythm
TI - Early cerebral thromboembolic complications after radiofrequency catheter
ablation of atrial fibrillation: incidence, characteristics, and risk factors
VL - 11
ID - 2861
ER -
TY - JOUR
AB - During a prospective trial of platelet-inhibiting drugs in patients with
transient ischaemic attacks (T.I.A.s), 14 patients had serious neurological
dysfunction and normal cerebral angiograms. The patients (mean age 37 years) had
neurological episodes over a period of 1-4 years consisting of acute non-
progressive strokes with residual symptoms. In 3 patients, the two cerebral
hemispheres were involved on different occasions. Cerebral angiograms showed no
significant atheromatous disease in the intracranial or extracranial vessels. 3
patients had mid-systolic clicks, 5 had systolic murmurs, and 2 patients had both a
click and a murmur. Holter electrocardiographic monitoring revealed atrial,
junctional, or ventricular extrasystoles (5 patients), paroxysmal atrial
fibrillation (3), and paroxysmal ventricular tachycardia (1). Left ventricular
angiography confirmed mitral-leaflet prolapse in all the patients. The focal nature
of the T.I.A.s suggests an embolic event, the embolus arising from the abnormal
mitral valve. In a patient not included in this series, a small antemortem left
atrial thrombus was found at necropsy.
AN - 69931
AU - Kostuk, W. J.
AU - Boughner, D. R.
AU - Barnett, H. J.
AU - Silver, M. D.
DA - Aug 13
DO - 10.1016/s0140-6736(77)91482-9
DP - NLM
ET - 1977/08/13
IS - 8033
J2 - Lancet (London, England)
KW - Adolescent
Adult
Aged
Arrhythmias, Cardiac/complications/etiology
Cerebrovascular Disorders/diagnostic imaging/*etiology
Female
Heart Valve Diseases/*complications/diagnosis
Humans
Male
Middle Aged
Mitral Valve
Prolapse/complications/diagnosis
Thrombosis/complications/etiology
LA - eng
N1 - Kostuk, W J
Boughner, D R
Barnett, H J
Silver, M D
Journal Article
England
Lancet. 1977 Aug 13;2(8033):313-6. doi: 10.1016/s0140-6736(77)91482-9.
PY - 1977
SN - 0140-6736 (Print)
0140-6736
SP - 313-6
ST - Strokes: A complication of mitral-leaflet prolapse?
T2 - Lancet
TI - Strokes: A complication of mitral-leaflet prolapse?
VL - 2
ID - 2714
ER -
TY - JOUR
AB - BACKGROUND AND OBJECTIVE: Atrial fibrillation (AF) is common and causes
impaired quality of life, an increased risk of stroke and death as well as frequent
hospital admissions. The majority of patients with AF require control of heart
rate. In this article , we summarise the limited evidence from clinical trials that
guides prescription, and present the rationale and protocol for a new randomised
trial. As rate control has not yet been shown to reduce mortality, there is a clear
need to compare the impact of therapy on quality of life, cardiac function and
exercise capacity. Such a trial should concentrate on the long-term effects of
treatment in the largest proportion of patients with AF, those with symptomatic
permanent AF, with the aim of improving patient well-being. DESIGN AND
INTERVENTION: The RAte control Therapy Evaluation in permanent Atrial Fibrillation
(RATE-AF) trial will enrol 160 participants with a prospective, randomised, open-
label, blinded end point design comparing initial rate control with digoxin or
bisoprolol. This will be the first head-to-head randomised trial of digoxin and
beta-blockers in AF. PARTICIPANTS: Recruited patients will be aged Ã¢Â‰Â¥60 years
with permanent AF and symptoms of breathlessness (equivalent to New York Heart
Association class II or above), with few exclusion criteria to maximise
generalisability to routine clinical practice. OUTCOME MEASURES: The primary
outcome is patient-reported quality of life, with secondary outcomes including
echocardiographic ventricular function, exercise capacity and biomarkers of
cellular and clinical response. Follow-up will occur at 6 and 12 months, with
feasibility components to inform the design of a future trial powered to detect a
difference in hospital admission. The RATE-AF trial will underpin an integrated
approach to management including biomarkers, functions and symptoms that will guide
future research into optimal, personalised rate control in patients with AF. ETHICS
AND DISSEMINATION: East Midlands-Derby Research Ethics Committee (16/EM/0178);
peer-reviewed publications. TRIAL REGISTRATION: Clinicaltrials.gov: NCT02391337;
ISRCTN: 95259705. Pre-results.
AD - Institute of Cardiovascular Sciences, University of Birmingham, Birmingham,
UK.
Cardiology, University Hospitals Birmingham NHS Trust, Birmingham, UK.
Cardiology, Sandwell & West Birmingham Hospitals NHS Trust, Birmingham, UK.
Centre for Patient Reported Outcomes Research, University of Birmingham,
Birmingham, UK.
Institute of Applied Health Research, University of Birmingham, Birmingham, UK.
Birmingham Clinical Trials Unit, University of Birmingham, Birmingham, UK.
(Lead for the Patient and Public Involvement panel), Birmingham, UK.
AN - 28729311
AU - Kotecha, D.
AU - Calvert, M.
AU - Deeks, J. J.
AU - Griffith, M.
AU - Kirchhof, P.
AU - Lip, G. Y.
AU - Mehta, S.
AU - Slinn, G.
AU - Stanbury, M.
AU - Steeds, R. P.
AU - Townend, J. N.
C2 - PMC5588987
DA - Jul 20
DO - 10.1136/bmjopen-2016-015099
DP - NLM
ET - 2017/07/22
IS - 7
J2 - BMJ open
KW - Adrenergic beta-1 Receptor Antagonists/administration & dosage
Aged
Anti-Arrhythmia Agents/administration & dosage
Bisoprolol/*administration & dosage
Digoxin/*administration & dosage
Female
Heart Rate
Hospitalization
Humans
Male
Middle Aged
Prospective Studies
Quality of Life
Research Design
Time
United Kingdom
Echocardiography
Protocols & guidelines
Rate-af
atrial fibrillation
quality of life
have completed the ICMJE uniform disclosure form (www.icmje.org/coi_disclosure.pdf)
and declare: DK reports grants from Menarini, during the conduct of the study
non-financial support from Daiichi Sankyo and personal fees from AtriCure, outside
the submitted work. MC reports grants from the National Institute of Health
Research, during the conduct of the study
and personal fees from Astella Pharma and
Ferring Pharma, outside the submitted work. PK reports consulting fees and
honoraria
from Bayer Healthcare, Boehringer Ingelheim, Bristol-Myers Squibb, Daiichi Sankyo,
Medtronic, Pfizer and Servier, all outside the submitted work
research grants from
Bristol-Myers Squibb, Pfizer, Cardiovascular Therapeutics, Daiichi Sankyo, Sanofi,
St. Jude Medical, German Federal Ministry for Education and Research (BMBF),
Fondation Leducq, German Research Foundation (DFG), European Union, British Heart
Foundation and Medical Research Council UK, all outside the submitted work
and is
listed on two patent applications on AF therapy and markers for AF, both outside
the
submitted work. GYHL has served as a consultant for Bayer, Astellas, Merck,
AstraZeneca, Sanofi, BMS/Pfizer, Biotronik, Portola and Boehringer Ingelheim, and
has been on the speakerâ€™s bureau for Bayer, BMS/Pfizer, Boehringer Ingelheim and
Sanofi Aventis. RPS is the President of the British Society of Echocardiography.
JJD, MG, MS. JNT, SM, GS report no competing interests.
LA - eng
N1 - 2044-6055
Kotecha, Dipak
Orcid: 0000-0002-2570-9812
Calvert, Melanie
Orcid: 0000-0002-1856-837x
Deeks, Jonathan J
Griffith, Michael
Kirchhof, Paulus
Orcid: 0000-0002-1881-0197
Lip, Gregory Yh
Mehta, Samir
Slinn, Gemma
Stanbury, Mary
Steeds, Richard P
Townend, Jonathan N
CDF-2015-08-074/Department of Health/United Kingdom
Clinical Trial, Phase IV
Journal Article
Multicenter Study
BMJ Open. 2017 Jul 20;7(7):e015099. doi: 10.1136/bmjopen-2016-015099.
PY - 2017
SN - 2044-6055
SP - e015099
ST - A review of rate control in atrial fibrillation, and the rationale and
protocol for the RATE-AF trial
T2 - BMJ Open
TI - A review of rate control in atrial fibrillation, and the rationale and
protocol for the RATE-AF trial
VL - 7
ID - 2779
ER -
TY - JOUR
AB - BACKGROUND: Atrial fibrillation and heart failure often coexist, causing
substantial cardiovascular morbidity and mortality. β blockers are indicated in
patients with symptomatic heart failure with reduced ejection fraction; however,
the efficacy of these drugs in patients with concomitant atrial fibrillation is
uncertain. We therefore meta-analysed individual-patient data to assess the
efficacy of β blockers in patients with heart failure and sinus rhythm compared
with atrial fibrillation. METHODS: We extracted individual-patient data from ten
randomised controlled trials of the comparison of β blockers versus placebo in
heart failure. The presence of sinus rhythm or atrial fibrillation was ascertained
from the baseline electrocardiograph. The primary outcome was all-cause mortality.
Analysis was by intention to treat. Outcome data were meta-analysed with an
adjusted Cox proportional hazards regression. The study is registered with
Clinicaltrials.gov, number NCT0083244, and PROSPERO, number CRD42014010012.
FINDINGS: 18,254 patients were assessed, and of these 13,946 (76%) had sinus rhythm
and 3066 (17%) had atrial fibrillation at baseline. Crude death rates over a mean
follow-up of 1·5 years (SD 1·1) were 16% (2237 of 13,945) in patients with sinus
rhythm and 21% (633 of 3064) in patients with atrial fibrillation. β-blocker
therapy led to a significant reduction in all-cause mortality in patients with
sinus rhythm (hazard ratio 0·73, 0·67-0·80; p<0·001), but not in patients with
atrial fibrillation (0·97, 0·83-1·14; p=0·73), with a significant p value for
interaction of baseline rhythm (p=0·002). The lack of efficacy for the primary
outcome was noted in all subgroups of atrial fibrillation, including age, sex, left
ventricular ejection fraction, New York Heart Association class, heart rate, and
baseline medical therapy. INTERPRETATION: Based on our findings, β blockers should
not be used preferentially over other rate-control medications and not regarded as
standard therapy to improve prognosis in patients with concomitant heart failure
and atrial fibrillation. FUNDING: Menarini Farmaceutica Internazionale
(administrative support grant).
AD - University of Birmingham Centre for Cardiovascular Sciences, Birmingham, UK;
Clinical Trials and Evaluation Unit, Royal Brompton and Harefield NHS Trust,
London, UK; Centre of Cardiovascular Research and Education in Therapeutics, Monash
University, Melbourne, VIC, Australia. Electronic address: d.kotecha@bham.ac.uk.
Centre for Statistics in Medicine, University of Oxford, Oxford, UK.
Centre of Cardiovascular Research and Education in Therapeutics, Monash University,
Melbourne, VIC, Australia.
Internal Medicine Department, Hospital Universitario Ramón y Cajal, Universidad de
Alcalá, Madrid, Spain.
National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial
College, London, UK; Hull York Medical School, University of Hull, Kingston upon
Hull, UK.
University of Birmingham Centre for Cardiovascular Sciences, Birmingham, UK; City
Hospital, Sandwell and West Birmingham NHS Trust, Birmingham, UK.
Monash University, Melbourne, VIC, Australia; Warwick University, Warwick, UK.
Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
University of Birmingham Centre for Cardiovascular Sciences, Birmingham, UK; City
Hospital, Sandwell and West Birmingham NHS Trust, Birmingham, UK; Department of
Cardiovascular Medicine, University Hospital Münster, Münster, Germany.
Centre of Cardiovascular Research and Education in Therapeutics, Monash University,
Melbourne, VIC, Australia; Department of Cardiology, Oslo University Hospital,
Oslo, Norway.
Nordic School of Public Health, Gothenburg, Sweden.
Department of Medical Sciences, Instituto di Ricovero e Cura a Carattere
Scientifico San Raffaele Pisana, Rome, Italy.
Division of Cardiology, University of Alberta, Edmonton, Canada.
Academic Cardiology, Castle Hill Hospital, Kingston upon Hull, UK.
Norwich Medical School, University of East Anglia, Norwich, UK.
AN - 25193873
AU - Kotecha, D.
AU - Holmes, J.
AU - Krum, H.
AU - Altman, D. G.
AU - Manzano, L.
AU - Cleland, J. G.
AU - Lip, G. Y.
AU - Coats, A. J.
AU - Andersson, B.
AU - Kirchhof, P.
AU - von Lueder, T. G.
AU - Wedel, H.
AU - Rosano, G.
AU - Shibata, M. C.
AU - Rigby, A.
AU - Flather, M. D.
DA - Dec 20
DO - 10.1016/s0140-6736(14)61373-8
DP - NLM
ET - 2014/09/07
IS - 9961
Atrial Fibrillation/complications/*drug therapy/*mortality
Electrocardiography
Heart Failure/complications/*drug therapy/*mortality
Humans
Patient Admission/statistics & numerical data
Stroke/mortality
LA - eng
N1 - 1474-547x
Kotecha, Dipak
Holmes, Jane
Krum, Henry
Altman, Douglas G
Manzano, Luis
Cleland, John G F
Lip, Gregory Y H
Coats, Andrew J S
Andersson, Bert
Kirchhof, Paulus
von Lueder, Thomas G
Wedel, Hans
Rosano, Giuseppe
Shibata, Marcelo C
Rigby, Alan
Flather, Marcus D
Beta-Blockers in Heart Failure Collaborative Group
Journal Article
Meta-Analysis
England
Lancet. 2014 Dec 20;384(9961):2235-43. doi: 10.1016/S0140-6736(14)61373-8. Epub
2014 Sep 2.
PY - 2014
SN - 0140-6736
SP - 2235-43
ST - Efficacy of β blockers in patients with heart failure plus atrial
fibrillation: an individual-patient data meta-analysis
T2 - Lancet
TI - Efficacy of β blockers in patients with heart failure plus atrial
fibrillation: an individual-patient data meta-analysis
VL - 384
ID - 2312
ER -
TY - JOUR
AB - INTRODUCTION: Ventricular fibrillation (VF) presents a complete disintegrated
myocardial activity associated with hemodynamic collapse and loss of consciousness
requiring urgent reanimation. VF mostly occurs following myocardial infarction and
endstage of ischemic heart disease in patients with ejection fraction less than
30%. MATERIAL AND METHODS: This paper analyzes occurrence of VF following coronary
artery revascularization in patients undergoing surgery at the Institute of
Cardiovascular Diseases in Sremska Kamenica. During the period 1994-1998, 3.186
patients underwent coronary artery revascularization procedure, whereas following
it VF occurred in 20 patients (0.63%). RESULTS AND DISCUSSION: In all patients VF
presented in the first postoperative week, while in 16 patients it occurred in the
first 3 days following surgery. Nine patients with VF underwent left coronary
artery revascularization with endarterectomy, 9 patients underwent right coronary
artery revascularization with endarterectomy. One patient had a left-ventricular
aneurysmectomy and 80% of patients had low ejection fraction rate--20-35%. After VF
in 75% of patients urgent reoperation was performed, and only one suffered from
thrombotic occlusion, that is perioerative infarction. After defibrillation
patients were treated with xylocaine, amiodarone and beta-blockers. During the 30-
day period following surgery, there were no lethal outcomes, whereas in the 24-
month period after surgery 3 patients died. Cardiac-related death occurred in one
patient, while two died due to cerebral insult. CONCLUSION: VF was not a frequent
complication in our patients. Effective antiarrhythmic drugs prevent repeated VF.
Beta-blockers, xy-locaine and amiodarone are drugs of choice for the treatment of
malignant cardiac rhythm disturbances.
AD - Institut za kardiovaskularne bolesti, Sremska Kamenica, Institutski put 4.
kovacdd@eunet.yu
AN - 12037931
AU - Kovacević, D.
AU - Kovacević, D.
AU - Batranović, U.
AU - Topalov, V.
DA - Jan-Feb
DO - 10.2298/mpns0202013k
DP - NLM
ET - 2002/06/01
IS - 1-2
J2 - Medicinski pregled
KW - Coronary Artery Bypass/*adverse effects
Endarterectomy
Humans
Intraoperative Complications
Ventricular Fibrillation/diagnosis/*etiology
LA - hrv
N1 - Kovacević, Dragan
Kovacević, Diana
Batranović, Uros
Topalov, Vasilije
English Abstract
Journal Article
Serbia
Med Pregl. 2002 Jan-Feb;55(1-2):13-8. doi: 10.2298/mpns0202013k.
OP - Fibrilacija komora nakon hirurske revaskularizacije.
PY - 2002
SN - 0025-8105 (Print)
0025-8105
SP - 13-8
ST - [Ventricular fibrillation after surgical revascularization]
T2 - Med Pregl
TI - [Ventricular fibrillation after surgical revascularization]
VL - 55
ID - 2842
ER -
TY - JOUR
AB - Atrial fibrillation is a common arrhythmia in patients with heart failure and
is responsible for substantial morbidity and mortality. Restoration and
preservation of sinus rhythm, therefore, has a premium. Of the numerous treatment
options available, many must be avoided because of their potential for adverse
effects or because of limited proof of efficacy in defined populations. Published
guidelines provide help by synthesizing clinical trial data into a recommended
approach. This article summarizes current information regarding the best methods
applicable to patients with left ventricular dysfunction for rate control, sinus
rhythm restoration and maintenance, and stroke prevention. New and evolving
therapies and how they might fit into the evolving treatment paradigm are also
briefly reviewed.
AD - Department of Medicine, Jefferson Medical College of Thomas Jefferson
University, Philadelphia, Pennsylvania 19096, USA. koweyp@casep.com
AN - 12670640
AU - Kowey, P. R.
AU - Yan, G. X.
AU - Winkel, E.
AU - Kao, W.
DA - Mar 20
DO - 10.1016/s0002-9149(02)03377-5
DP - NLM
ET - 2003/04/03
IS - 6a
KW - Amiodarone/therapeutic use
Atrial Fibrillation/drug therapy/etiology/physiopathology/*therapy
*Catheter Ablation
Flecainide/therapeutic use
*Heart Rate/drug effects
Humans
Phenethylamines/therapeutic use
Quinidine/therapeutic use
Sulfonamides/therapeutic use
LA - eng
N1 - Kowey, Peter R
Yan, Gan Xin
Winkel, Elaine
Kao, Walter
Journal Article
Review
United States
Am J Cardiol. 2003 Mar 20;91(6A):33D-38D. doi: 10.1016/s0002-9149(02)03377-5.
PY - 2003
SN - 0002-9149 (Print)
0002-9149
SP - 33d-38d
ST - Pharmacologic and nonpharmacologic options to maintain sinus rhythm:
guideline-based and new approaches
T2 - Am J Cardiol
TI - Pharmacologic and nonpharmacologic options to maintain sinus rhythm:
guideline-based and new approaches
VL - 91
ID - 2668
ER -
TY - JOUR
AB - Since its introduction in 1960, CPR has evolved into a complex program
involving not only the medical community but also the lay public. Currently,
program activities include instruction of the lay public in basic life support
techniques, development and deployment of emergency medical systems,
recommendations for drug protocols for advanced cardiac life support and, most
recently, introduction of new methods for tissue protection following
resuscitation. After 25 years of experience, we are beginning to understand the
pathophysiology of tissue ischemia during cardiac arrest and the interventions
required to improve chances of survival and quality of life of the cardiac arrest
victim. Recent data in the literature suggest that modification of certain
interventions in the resuscitation program may be needed. The poor neurologic
outcomes with prolonged standard CPR show that it is not protective after 4 to 6
minutes of cardiac arrest. Modifications to this technique, including SVC-CPR or
IAC-CPR, have not been shown to increase resuscitability or hospital discharge
rates. Human studies of open-chest cardiac massage are needed to evaluate this
option. Defibrillation is the definitive treatment for ventricular fibrillation.
Greater emphasis should be placed on the earliest possible delivery of this
treatment modality. Computerized defibrillators may provide greater and earlier
access to defibrillation in the homes of patients at high risk of ventricular
fibrillation. They may also be applicable by untrained public service personnel
(police and firemen), individuals in geographically inaccessible areas (aircraft),
or emergency medical technicians in rural areas where skill retention is a
significant problem. Calcium has no proved benefit in cardiac resuscitation. There
is biochemical evidence that it may be harmful in brain resuscitation. Its use in
resuscitation should be discontinued. The dose of epinephrine currently advocated
in the ACLS protocols may be inadequate to increase aortic diastolic pressure and
coronary and cerebral perfusion pressures and thus aid resuscitation. Animal
studies indicate that substantial increases in the current dosage are needed to
achieve these effects. Human studies are needed to verify these results. A role for
calcium antagonists in the treatment of postarrest encephalopathy has been
demonstrated in animals and is currently undergoing clinical trials. Iron-dependent
lipid peroxidative cell membrane injury may be important in the pathogenesis of
postarrest encephalopathy. Animal studies suggest that the iron chelator
deferoxamine may have a significant therapeutic role in the treatment of postarrest
encephalopathy.
AN - 3513507
AU - Krause, G. S.
AU - Kumar, K.
AU - White, B. C.
AU - Aust, S. D.
AU - Wiegenstein, J. G.
DA - Apr
DO - 10.1016/0002-8703(86)90114-6
DP - NLM
ET - 1986/04/01
IS - 4
KW - Animals
Arrhythmias, Cardiac/complications/metabolism/physiopathology
Brain Ischemia/prevention & control
Calcium/metabolism
*Coronary Circulation
Esophagus
Heart Arrest/etiology/*therapy
Humans
Intubation
Iron/metabolism
Lipid Peroxides/metabolism
Myocardial Infarction/*complications/metabolism/physiopathology
Myocardium/*metabolism
Resuscitation/*methods
LA - eng
N1 - Krause, G S
Kumar, K
White, B C
Aust, S D
Wiegenstein, J G
GM33443/GM/NIGMS NIH HHS/United States
Journal Article
Review
United States
Am Heart J. 1986 Apr;111(4):768-80. doi: 10.1016/0002-8703(86)90114-6.
PY - 1986
SN - 0002-8703 (Print)
0002-8703
SP - 768-80
ST - Ischemia, resuscitation, and reperfusion: mechanisms of tissue injury and
prospects for protection
T2 - Am Heart J
TI - Ischemia, resuscitation, and reperfusion: mechanisms of tissue injury and
prospects for protection
VL - 111
ID - 2838
ER -
TY - JOUR
AB - BACKGROUND AND PURPOSE: Hypothermia is effective in improving outcome in
experimental models of brain infarction. We studied the feasibility and safety of
hypothermia in patients with acute ischemic stroke treated with thrombolysis.
METHODS: An open study design was used. All patients presented with major ischemic
stroke (National Institutes of Health Stroke Scale [NIHSS] score >15) within 6
hours of onset. After informed consent, patients with a persistent NIHSS score of
>8 were treated with hypothermia to 32+/-1 degrees C for 12 to 72 hours depending
on vessel patency. All patients were monitored in the neurocritical care unit for
complications. A modified Rankin Scale was measured at 90 days and compared with
concurrent controls. RESULTS: Ten patients with a mean age of 71.1+/-14.3 years and
an NIHSS score of 19.8+/-3.3 were treated with hypothermia. Nine patients served as
concurrent controls. The mean time from symptom onset to thrombolysis was 3.1+/-1.4
hours and from symptom onset to initiation of hypothermia was 6.2+/-1.3 hours. The
mean duration of hypothermia was 47.4+/-20.4 hours. Target temperature was achieved
in 3.5+/-1.5 hours. Noncritical complications in hypothermia patients included
bradycardia (n=5), ventricular ectopy (n=3), hypotension (n=3), melena (n=2), fever
after rewarming (n=3), and infections (n=4). Four patients with chronic atrial
fibrillation developed rapid ventricular rate, which was noncritical in 2 and
critical in 2 patients. Three patients had myocardial infarctions without sequelae.
There were 3 deaths in patients undergoing hypothermia. The mean modified Rankin
Scale score at 3 months in hypothermia patients was 3.1+/-2.3. CONCLUSION: Induced
hypothermia appears feasible and safe in patients with acute ischemic stroke even
after thrombolysis. Refinements of the cooling process, optimal target temperature,
duration of therapy, and, most important, clinical efficacy, require further study.
AD - Cerebrovascular Center, The Cleveland Clinic Foundation, Cleveland, Ohio,
USA. krieged@ccf.org
AN - 11486115
AU - Krieger, D. W.
AU - De Georgia, M. A.
AU - Abou-Chebl, A.
AU - Andrefsky, J. C.
AU - Sila, C. A.
AU - Katzan, I. L.
AU - Mayberg, M. R.
AU - Furlan, A. J.
DA - Aug
DO - 10.1161/01.str.32.8.1847
DP - NLM
ET - 2001/08/04
IS - 8
J2 - Stroke
KW - Acute Disease
Adult
Aged
Aged, 80 and over
Bradycardia/etiology/genetics
Brain Ischemia/complications/diagnosis/*therapy
Feasibility Studies
Female
Fever/etiology
Humans
*Hypothermia, Induced/adverse effects/mortality
Infections/etiology
Male
Melena/etiology
Middle Aged
Pilot Projects
Stroke/complications/diagnosis/*therapy
Time Factors
Treatment Outcome
Ventricular Premature Complexes/etiology
LA - eng
N1 - 1524-4628
Krieger, D W
De Georgia, M A
Abou-Chebl, A
Andrefsky, J C
Sila, C A
Katzan, I L
Mayberg, M R
Furlan, A J
Clinical Trial
Journal Article
United States
Stroke. 2001 Aug;32(8):1847-54. doi: 10.1161/01.str.32.8.1847.
PY - 2001
SN - 0039-2499
SP - 1847-54
ST - Cooling for acute ischemic brain damage (cool aid): an open pilot study of
induced hypothermia in acute ischemic stroke
T2 - Stroke
TI - Cooling for acute ischemic brain damage (cool aid): an open pilot study of
induced hypothermia in acute ischemic stroke
VL - 32
ID - 2549
ER -
TY - JOUR
AB - OBJECTIVES: Takotsubo cardiomyopathy (TC) is characterized by left-ventricle
apical ballooning with elevated cardiac biomarkers and electrocardiographic changes
similar to an acute coronary syndrome. We studied the prevalence, in-hospital
mortality, and predictors of mortality in TC. METHODS: All patients ≥18 years of
age diagnosed with TC were identified in the Nationwide Inpatient Sample (NIS)
2009-2010 database using the 9th revision of the International Classification of
Diseases (ICD) 429.83. Demographics, conventional risk factors (diabetes,
hypertension, hyperlipidemia, and tobacco abuse), acute critical illnesses like
sepsis, acute cerebrovascular disease (cerebrovascular accident; CVA), acute
respiratory insufficiency, and acute renal failure, and chronic conditions
(anxiety, depression, and malignancy) were studied. RESULTS: The prevalence of TC
was 0.02% (n = 7,510). The total in-hospital mortality rate was 2.4%, with a higher
mortality in men (4.8%) than in women (2.1%). Sepsis (9 vs. 4.2%; p < 0.01) was
more prevalent in men with an increased prevalence of other critical illness,
although this was not statistically significant. Age (OR 1.05; 95% CI 1.01-1.09),
malignancy (OR 3.38; 95% CI 1.35-8.41), acute renal failure (OR 5.4; 95% CI 2.2-
13.7), acute CVA (OR 9.4; 95% CI 2.96-29.8), and acute respiratory failure (OR
11.1; 95% CI 3.9-31.1) predicted mortality in fully adjusted models. CONCLUSION: A
higher mortality was seen in men, likely related to the increased prevalence of
acute critical illnesses, ventricular arrhythmia, and sudden cardiac arrest. Acute
CVA and respiratory failure were the strongest predictors of mortality. © 2015 S.
Karger AG, Basel.
AD - Department of Cardiology, Einstein Institute for Heart and Vascular Health,
Albert Einstein Medical Center, Philadelphia, Pa., USA.
AN - 26159108
AU - Krishnamoorthy, P.
AU - Garg, J.
AU - Sharma, A.
AU - Palaniswamy, C.
AU - Shah, N.
AU - Lanier, G.
AU - Patel, N. C.
AU - Lavie, C. J.
AU - Ahmad, H.
DO - 10.1159/000430782
DP - NLM
ET - 2015/07/15
IS - 2
J2 - Cardiology
LA - eng
N1 - 1421-9751
Krishnamoorthy, Parasuram
Garg, Jalaj
Sharma, Abhishek
Palaniswamy, Chandrasekar
Shah, Neeraj
Lanier, Gregg
Patel, Nainesh C
Lavie, Carl J
Ahmad, Hasan
Journal Article
Switzerland
Cardiology. 2015;132(2):131-136. doi: 10.1159/000430782. Epub 2015 Jul 7.
PY - 2015
SN - 0008-6312
SP - 131-136
ST - Gender Differences and Predictors of Mortality in Takotsubo Cardiomyopathy:
Analysis from the National Inpatient Sample 2009-2010 Database
T2 - Cardiology
TI - Gender Differences and Predictors of Mortality in Takotsubo Cardiomyopathy:
Analysis from the National Inpatient Sample 2009-2010 Database
VL - 132
ID - 3139
ER -
TY - JOUR
AB - BACKGROUND: Although serum cardiac troponin I (cTnI) and plasma brain
natriuretic peptide (BNP) have become clinically important tools as diagnostic and
prognostic markers for ischemic heart disease and heart failure, the usefulness of
these biomarkers for risk stratification of hypertrophic cardiomyopathy (HCM) is
not clear. METHODS AND RESULTS: We studied 167 patients with HCM, and cTnI and BNP
were measured. During follow-up (38.5 months), 20 patients suffered from
cardiovascular events: HCM-related deaths in 6, hospitalization for heart failure
in 8, embolic stroke in 5 and 1 patient with spontaneous sustained ventricular
tachycardia. Patients with high cTnI values (≥0.04 ng/ml) had more frequent
cardiovascular events than did those with low cTnI values (P=0.008). Similarly,
there were more frequent adverse events in the high BNP group (≥200 pg/ml) than in
the low BNP group (P=0.002). When groups were allocated according to both cTnI and
BNP measurements, serum cTnI used in conjunction with BNP further improved the
prognostic value; patients with both high cTnI and BNP values had an 11.7-fold
increased risk of cardiovascular events compared with those with both low cTnI and
BNP values. CONCLUSIONS: CTnI and BNP are useful parameters for identifying
patients at risk for clinical deteriorations, and combined measurements of these
biomarkers further improves the prognostic value of increased cardiovascular events
in HCM.
AD - Department of Medicine and Geriatrics, Kochi Medical School, Nankoku, Japan.
AN - 21304210
AU - Kubo, T.
AU - Kitaoka, H.
AU - Okawa, M.
AU - Yamanaka, S.
AU - Hirota, T.
AU - Baba, Y.
AU - Hayato, K.
AU - Yamasaki, N.
AU - Matsumura, Y.
AU - Yasuda, N.
AU - Sugiura, T.
AU - Doi, Y. L.
DO - 10.1253/circj.cj-10-0782
DP - NLM
ET - 2011/02/10
IS - 4
KW - Aged
Biomarkers/blood
Cardiomyopathy, Hypertrophic/*blood/complications/diagnosis
Embolism/blood/diagnosis/etiology
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prognosis
Stroke/blood/diagnosis/etiology
Tachycardia, Ventricular/blood/diagnosis/etiology
Troponin I/*blood
LA - eng
N1 - 1347-4820
Kubo, Toru
Kitaoka, Hiroaki
Okawa, Makoto
Yamanaka, Shigeo
Hirota, Takayoshi
Baba, Yuichi
Hayato, Kayo
Yamasaki, Naohito
Matsumura, Yoshihisa
Yasuda, Nobufumi
Sugiura, Tetsuro
Doi, Yoshinori L
Journal Article
Japan
Circ J. 2011;75(4):919-26. doi: 10.1253/circj.cj-10-0782. Epub 2011 Feb 4.
PY - 2011
SN - 1346-9843
SP - 919-26
ST - Combined measurements of cardiac troponin I and brain natriuretic peptide are
useful for predicting adverse outcomes in hypertrophic cardiomyopathy
T2 - Circ J
TI - Combined measurements of cardiac troponin I and brain natriuretic peptide are
useful for predicting adverse outcomes in hypertrophic cardiomyopathy
VL - 75
ID - 2404
ER -
TY - JOUR
AB - AIMS: To test the hypothesis that Qr in V(1)is a predictor of pulmonary
embolism, right ventricular strain, and adverse clinical outcome. METHODS AND
RESULTS: ECG's from 151 patients with suspected pulmonary embolism were blindly
interpreted by two observers. Echocardiography, troponin I, and pro-brain
natriuretic peptide levels were obtained in 75 patients with pulmonary embolism. Qr
in V(1)(14 vs 0 in controls; p<0.0001) and ST elevation in V(1)> or =1 mV (15 vs 1
in controls; p=0.0002) were more frequently present in patients with pulmonary
embolism. Sensitivity and specificity of Qr in V(1)and T wave inversion in V(2)for
predicting right ventricular dysfunction were 31/97% and 45/94%, respectively.
Three of five patients who died in-hospital and 11 of 20 patients with a
complicated course, presented with Qr in V(1). After adjustment for right
ventricular strain including ECG, echocardiography, pro-brain natriuretic peptide
and troponin I levels, Qr in V(1)(OR 8.7, 95%CI 1.4-56.7; p=0.02) remained an
independent predictor of adverse outcome. CONCLUSIONS: Among the ECG signs seen in
patients with acute pulmonary embolism, Qr in V(1)is closely related to the
presence of right ventricular dysfunction, and is an independent predictor of
adverse clinical outcome.
AD - Cardiology, Swiss Cardiovascular Center Bern, University Hospital, 3010 Bern,
Switzerland. nkucher@freesurf.ch
AN - 12804925
AU - Kucher, N.
AU - Walpoth, N.
AU - Wustmann, K.
AU - Noveanu, M.
AU - Gertsch, M.
DA - Jun
DO - 10.1016/s0195-668x(03)00132-5
DP - NLM
ET - 2003/06/14
IS - 12
Echocardiography
Electrocardiography
Fibrin Fibrinogen Degradation Products/analysis
Humans
Observer Variation
Prognosis
Pulmonary Embolism/*diagnosis/physiopathology
Tomography, Spiral Computed/methods
Ventricular Dysfunction, Right/*diagnosis/physiopathology
LA - eng
N1 - Kucher, Nils
Walpoth, Nazan
Wustmann, Kerstin
Noveanu, Markus
Gertsch, Marc
Journal Article
England
Eur Heart J. 2003 Jun;24(12):1113-9. doi: 10.1016/s0195-668x(03)00132-5.
PY - 2003
SN - 0195-668X (Print)
0195-668x
SP - 1113-9
ST - QR in V1--an ECG sign associated with right ventricular strain and adverse
clinical outcome in pulmonary embolism
T2 - Eur Heart J
TI - QR in V1--an ECG sign associated with right ventricular strain and adverse
clinical outcome in pulmonary embolism
VL - 24
ID - 2892
ER -
TY - JOUR
AB - Although preoperative atrial fibrillation (AF) is common in patients
undergoing continuous-flow left ventricular assist device (CF-LVAD) implantation,
how AF affects outcomes remains unclear. We analyzed our single-center experience
with CF-LVAD implantation to determine whether preoperative AF was associated with
inferior outcomes. From November 2003 through March 2016, 526 patients with chronic
heart failure underwent implantation with the HeartMate II (HMII; n = 403) or
HeartWare VAD (HVAD; n = 123). We identified 229 patients (165 HMII, 65 HVAD) who
had preoperative AF and compared them with non-preoperative AF patients regarding
the incidence of postoperative stroke, as well as long-term survival. After
implantation, 139 patients had a stroke (78 non-preoperative AF patients [26.2%],
61 preoperative AF patients [26.6%]; p = 0.84). The rate of events per patient-year
was 0.19 in non-preoperative AF patients and 0.22 in preoperative AF patients (p =
0.84). Survival was not significantly different between the two groups (p = 0.60).
In Cox regression, preoperative AF was not associated with postoperative stroke
(odds ratio: 1.13; 95% confidence interval [CI]: 0.74-1.74; p = 0.55) or survival
(hazard ratio: 0.93; 95% CI: 0.71-1.25; p = 0.66). We conclude that in CF-LVAD
recipients, preoperative AF did not diminish perioperative or long-term survival or
increase the risk of postoperative stroke. These findings suggest that performing
concomitant AF ablation during CF-LVAD implantation may be unnecessary.
AD - From the Division of Cardiothoracic Transplant and Assist Devices, Baylor
College of Medicine, Houston, Texas.
Department of Cardiopulmonary Transplantation and the Center for Cardiac Support,
Texas Heart Institute, Houston, Texas.
Department of Cardiothoracic Surgery, Tokyo Metropolitan Geriatric Hospital and
Institute of Gerontology, Tokyo, Japan.
AN - 29485425
AU - Kurihara, C.
AU - Critsinelis, A.
AU - Kawabori, M.
AU - Sugiura, T.
AU - Civitello, A. B.
AU - Morgan, J. A.
DA - Sep/Oct
DO - 10.1097/mat.0000000000000762
DP - NLM
ET - 2018/02/28
IS - 5
J2 - ASAIO journal (American Society for Artificial Internal Organs : 1992)
Female
Heart Failure/mortality/surgery
*Heart-Assist Devices
Humans
Incidence
Male
Middle Aged
Treatment Outcome
LA - eng
N1 - 1538-943x
Kurihara, Chitaru
Critsinelis, Andre
Kawabori, Masashi
Sugiura, Tadahisa
Civitello, Andrew B
Morgan, Jeffrey A
Journal Article
United States
ASAIO J. 2018 Sep/Oct;64(5):594-600. doi: 10.1097/MAT.0000000000000762.
PY - 2018
SN - 1058-2916
SP - 594-600
ST - Effect of Preoperative Atrial Fibrillation on Patients with Chronic Heart
Failure Who Undergo Long-Term Continuous-Flow LVAD Implantation
T2 - Asaio j
TI - Effect of Preoperative Atrial Fibrillation on Patients with Chronic Heart
Failure Who Undergo Long-Term Continuous-Flow LVAD Implantation
VL - 64
ID - 2431
ER -
TY - JOUR
AB - Incorrect implantation of a ventricular pacemaker (PM) lead into the left
ventricle (LV) is a known problem associated with permanent pacing. The optimal
management of such cases identified late has not been clearly established.
Generally acceptable management options are: open-chest cardiac surgery using
cardio-pulmonary bypass, chronic anticoagulation and antiplatelet-drugs therapy.
Rarely, the problem is solved by percutaneous LV lead extraction. We present a case
of a patient with DDD pacing and ventricular lead implanted incorrectly into the LV
apex region via an atrial septal defect eight years ago. Chronic PM pocket
infection developed after replacement of the device. Both leads were extracted
percutaneously, and the embolic protection system (Filter-Wire EZ, Boston
Scientific) was used to reduce cerebral circulation embolism. The hardest
connective tissue adhesions affecting the lead and the anodal ring were found in
the LV. Less dense surrounding fibrous tissue around the lead was present at all
levels of the venous course of the lead and in the right atrium. Very small
fragments of apparently connective tissue remnants were found in cerebral
circulation protection filters, and had been removed after the procedure. We
conclude that old, permanently implanted LV leads may be extracted percutaneously,
especially when there is an increased risk of cardiac surgery, or where the
patient's consent for surgical treatment is lacking. In order to perform the
procedure it is recommended to establish a cerebral protection system and
intraoperative transoesophageal echocardiography which are mandatory for successful
lead removal.
AD - Klinika Elektrokardiologii Krakowski Szpital Specjalistyczny im Jana Pawła
II. krzysiek.boczar@gmail.com.
AN - 24399593
AU - Kutarski, A.
AU - Pietura, R.
AU - Tomaszewski, A.
AU - Czajkowski, M.
AU - Boczar, K.
DO - 10.5603/kp.2013.0333
DP - NLM
ET - 2014/01/09
IS - 12
KW - Bradycardia/diagnosis/etiology/therapy
Electrocardiography
Electrodes, Implanted/*adverse effects
Equipment Failure
Fistula/diagnosis/therapy
Heart Ventricles/*diagnostic imaging
Humans
Intracranial Aneurysm/prevention & control
Male
Middle Aged
Staphylococcal Infections/etiology/therapy
LA - eng
N1 - 1897-4279
Kutarski, Andrzej
Pietura, Radosław
Tomaszewski, Andrzej
Czajkowski, Marek
Boczar, Krzysztof
Case Reports
Journal Article
Poland
Kardiol Pol. 2013;71(12):1317-21. doi: 10.5603/KP.2013.0333.
PY - 2013
SN - 0022-9032
SP - 1317-21
ST - Transvenous extraction of an eight-year-old ventricular lead accidentally
implanted into the left ventricle
T2 - Kardiol Pol
TI - Transvenous extraction of an eight-year-old ventricular lead accidentally
implanted into the left ventricle
VL - 71
ID - 2836
ER -
TY - JOUR
AB - BACKGROUND: Percutaneous atrial septal defect (ASD) closure is a routine
procedure to prevent right ventricular failure, pulmonary hypertension, or
paradoxical embolism. The latter is the typical reason for percutaneous patent
foramen ovale (PFO) closure. Atrial enlargement represents a risk for develop-ing
atrial fibrillation (AF). Percutaneous left atrial appendage (LAA) closure is
emerging as a preven-tive therapy for patients in AF who suffered from a previous
stroke or bleeding (secondary prevention) or patients without previous stroke or
bleeding (primary prevention). Percutaneous septal closure, particularly that of
large ASDs, may inhibit future percutaneous left atrial access when required for
LAA closure. Reported herein is the feasibility and safety of concomitant
percutaneous closure of the LAA and a septal shunt, mostly large ASDs, in patients
without AF, in the sense of "primary primary" preventive LAA closure. The first
"primary" relates to "in anticipation of AF" and potentially also for "for
prevention of AF". The second "primary" relates to "prevention of stroke or
bleeding". METHODS: Thirteen consecutive patients, older than 40 years without any
clinical or electrocardio-graphic evidence of AF, underwent percutaneous closure of
large ASDs or PFOs in the presence of enlarged atria at the university hospitals of
Bern and Zurich between April 2013 and June 2015. They concomitantly received
"primary primary" preventive LAA closure after informed consent. RESULTS: Mean
patient age was 58 ± 9 years (46% male). Procedural success was achieved in all pa-
tients and no major adverse events occurred acutely or during the following 2.0 ±
0.8 years. No patient developed AF. CONCLUSIONS: Concomitant closure of ASD or PFO
in the presence of enlarged atria and LAA for "primary primary" prevention appears
feasible and safe but has yet to prove its justification.
AD - University Heart Center Zurich. fabian.nietlispach@usz.ch.
AN - 28840592
AU - Kuwata, S.
AU - Vierecke, J.
AU - Gloekler, S.
AU - Maisano, F.
AU - Meier, B.
AU - Nietlispach, F.
DO - 10.5603/CJ.a2017.0097
DP - NLM
ET - 2017/08/26
IS - 2
KW - Angiography
Atrial Fibrillation/diagnosis/etiology/*prevention & control
Cardiac Catheterization/methods
Electrocardiography
Female
Fluoroscopy
Follow-Up Studies
Heart Septal Defects, Atrial/complications/diagnosis/*surgery
Humans
Male
Middle Aged
Primary Prevention/*methods
Secondary Prevention/methods
Surgery, Computer-Assisted/*methods
*atrial septal defect closure
*left atrial appendage closure
*patent foramen ovale closure
LA - eng
N1 - 1897-5593
Kuwata, Shingo
Vierecke, Juliane
Gloekler, Steffen
Maisano, Francesco
Meier, Bernhard
Nietlispach, Fabian
Journal Article
Multicenter Study
Poland
Cardiol J. 2018;25(2):179-187. doi: 10.5603/CJ.a2017.0097. Epub 2017 Aug 25.
PY - 2018
SN - 1898-018x
SP - 179-187
ST - Left atrial appendage closure for "primary primary" prevention during
percutaneous closure of septal defects in patients with large atria but no atrial
fibrillation
T2 - Cardiol J
TI - Left atrial appendage closure for "primary primary" prevention during
percutaneous closure of septal defects in patients with large atria but no atrial
fibrillation
VL - 25
ID - 2346
ER -
TY - JOUR
AB - OBJECTIVE: First-degree atrioventricular block is frequently encountered in
clinical practice and is generally considered a benign process. However, there is
emerging evidence that prolonged PR interval may be associated with adverse
outcomes. This study aims to determine if prolonged PR interval is associated with
adverse cardiovascular outcomes and mortality. METHODS: We searched MEDLINE and
EMBASE for studies that evaluated clinical outcomes associated with prolonged and
normal PR intervals. Relevant studies were pooled using random effects meta-
analysis for risk of mortality, cardiovascular mortality, heart failure, coronary
heart disease, atrial fibrillation and stroke or transient ischaemic attack (TIA).
Sensitivity analyses were performed considering the population type and the use of
adjustments. RESULTS: Our search yielded 14 studies that were undertaken between
1972 and 2011 with 400,750 participants. Among the studies that adjusted for
potential confounders, the pooled results suggest an increased risk of mortality
with prolonged PR interval risk ratio (RR) 1.24 95% CI 1.02 to 1.51, five studies.
Prolonged PR interval was associated with significant risk of heart failure or left
ventricular dysfunction (RR 1.39 95% CI 1.18 to 1.65, three studies) and atrial
fibrillation (RR 1.45 95% CI 1.23 to 1.71, eight studies) but not cardiovascular
mortality, coronary heart disease or myocardial infarction or stroke or TIA.
Similar observations were recorded when limited to studies of first-degree heart
block. CONCLUSIONS: Data from observational studies suggests a possible association
between prolonged PR interval and significant increases in atrial fibrillation,
heart failure and mortality. Future prospective studies are needed to confirm the
relationships reported, consider possible mechanisms and define the optimal
monitoring strategy for such patients.
AD - Keele Cardiovascular Research Group, Institutes of Science and Technology in
Medicine and Primary Care and Health Sciences, Stoke-on-Trent, UK The Heart Centre,
Royal Stoke University Hospital, Stoke-on-Trent, UK.
Keele Cardiovascular Research Group, Institutes of Science and Technology in
Medicine and Primary Care and Health Sciences, Stoke-on-Trent, UK Cardiology
Department, St Helens and Knowsley Teaching Hospital (NHS) Trust, Whiston Hospital,
Prescot, UK.
The Heart Centre, Royal Stoke University Hospital, Stoke-on-Trent, UK.
Epidemiology Group, The Institute of Applied Health Sciences, University of
Aberdeen, Aberdeen, UK.
Farr Institute, University of Manchester, Manchester, UK.
Department of Public Health & Primary Care, Norwich Medical School, University of
East Anglia, Norwich, UK.
Keele Cardiovascular Research Group, Institutes of Science and Technology in
Medicine and Primary Care and Health Sciences, Stoke-on-Trent, UK The Heart Centre,
Royal Stoke University Hospital, Stoke-on-Trent, UK Farr Institute, University of
Manchester, Manchester, UK.
AN - 26879241
AU - Kwok, C. S.
AU - Rashid, M.
AU - Beynon, R.
AU - Barker, D.
AU - Patwala, A.
AU - Morley-Davies, A.
AU - Satchithananda, D.
AU - Nolan, J.
AU - Myint, P. K.
AU - Buchan, I.
AU - Loke, Y. K.
AU - Mamas, M. A.
DA - May
DO - 10.1136/heartjnl-2015-308956
DP - NLM
ET - 2016/02/18
IS - 9
KW - Adult
Aged
Aged, 80 and over
Atrioventricular Block/*complications
Brugada Syndrome/complications
Cardiac Conduction System Disease
Female
Humans
Male
Middle Aged
Observational Studies as Topic
Prognosis
LA - eng
N1 - 1468-201x
Kwok, Chun Shing
Rashid, Muhammad
Beynon, Rhys
Barker, Diane
Patwala, Ashish
Morley-Davies, Adrian
Satchithananda, Duwarakan
Nolan, James
Myint, Phyo K
Orcid: 0000-0003-3852-6158
Buchan, Iain
Loke, Yoon K
Mamas, Mamas A
MC_PC_13042/Medical Research Council/United Kingdom
MR/K006665/1/Medical Research Council/United Kingdom
Journal Article
Meta-Analysis
Review
Systematic Review
England
Heart. 2016 May;102(9):672-80. doi: 10.1136/heartjnl-2015-308956. Epub 2016 Feb 15.
PY - 2016
SN - 1355-6037
SP - 672-80
ST - Prolonged PR interval, first-degree heart block and adverse cardiovascular
outcomes: a systematic review and meta-analysis
T2 - Heart
TI - Prolonged PR interval, first-degree heart block and adverse cardiovascular
outcomes: a systematic review and meta-analysis
VL - 102
ID - 2821
ER -
TY - JOUR
AB - To evaluate the significance of episodes of cerebral embolism in patients
with mitral valve disease in Korea, 128 patients with echocardiographic diagnosis
of mitral valve disease were examined. Among these, 82 patients had predominant
mitral stenosis. 1. The clinical features of 82 patients with mitral stenosis have
been reviewed to elucidate the factors favoring cerebral embolism which occurred in
19 patients, i.e., incidence of 23.2%. 2. Atrial fibrillation was present in 16 of
19 patients with cerebral embolism (84.2%). Cerebral embolic episodes occurred in
16 of 47 patients with atrial fibrillation (34.0%). 3. The mean age (55.3 ± 12.1
years) of patients without cerebral embolism was significantly older than that
(43.2 ± 14.6 years) of patients without cerebral embolism (P<0.005). 4. There was
no significant relationship between the incidence of embolism and sex, left atrial
thrombi, left atrium/aortic root diameter, mitral valvular orifice area, mitral
valvular vegetation or calcification, left ventricular enddiastolic dimension or
left ventricular posterior wall thickness. Cerebral embolism is common in patients
with mitral stenosis in our country. The presence of atrial fibrillation and low
cardiac output increase the attack of cerebral emboli whereas the severity of
mitral stenosis, as judged by valve area, may not correlate with the occurrence of
emboli. The best treatment for cerebral embolism is prevention. Therefore, we
believe that more vigorous treatment of patients with mitral valve disease who are
old or associated with atrial fibrillation as well as previous embolic history is
indicated.
AN - 15759378
AU - Kwon, O.
AU - Kim, M. H.
AU - Kim, K. S.
AU - Bae, J. H.
AU - Kim, M. S.
AU - Song, J. S.
C2 - PMC4534884
DA - Jan
DO - 10.3904/kjim.1986.1.1.60
DP - NLM
ET - 1986/01/01
IS - 1
J2 - The Korean journal of internal medicine
KW - Adolescent
Adult
Aged
Aged, 80 and over
Calcinosis/etiology
Child
Echocardiography
Female
Humans
Male
Middle Aged
Mitral Valve Stenosis/*complications/diagnostic imaging
Recurrence
LA - eng
N1 - 2005-6648
Kwon, O
Kim, M H
Kim, K S
Bae, J H
Kim, M S
Song, J S
Journal Article
Korean J Intern Med. 1986 Jan;1(1):60-6. doi: 10.3904/kjim.1986.1.1.60.
PY - 1986
SN - 1226-3303 (Print)
1226-3303
SP - 60-6
ST - A study on cerebral embolism in mitral stenosis
T2 - Korean J Intern Med
TI - A study on cerebral embolism in mitral stenosis
VL - 1
ID - 2970
ER -
TY - JOUR
AB - Two-hundred seventy consecutive patients with "unexplained cerebral ischemia"
were studied with transesophageal echocardiography to determine the value of this
test in identifying potential cardiac sources of cerebral embolism. The findings of
this group were compared with those of 772 consecutive patients undergoing
transesophageal echocardiographic evaluation for indications other than cerebral
ischemia. This study also examined this group of patients with unexplained cerebral
ischemia to determine differences in relation to underlying cardiac rhythm and
patient age. Intracardiac thrombus, atrial septal aneurysm, patent foramen ovale,
spontaneous left atrial contrast and protruding debris in the thoracic aorta were
found more often in patients with unexplained cerebral ischemia. Wall motion
abnormalities of the left ventricle, as well as mild to moderate valvular lesions
including mitral valve prolapse, were found to be similar in both groups.
Spontaneous left atrial contrast, as well as mild to moderate valvular
abnormalities, were found more often in patients with atrial fibrillation (22% of
the group with unexplained cerebral ischemia). However, the presence of
intracardiac thrombus was no more frequent in patients with atrial fibrillation
than in those with normal sinus rhythm. Patients aged > 50 years were found to have
atrial fibrillation and larger left atrial size more often than their younger
cohorts, as well as a greater incidence of valvular abnormalities and left
ventricular wall motion abnormalities. Mitral valve prolapse was seen more
frequently in the younger cohort of patients.
AD - Department of Internal Medicine, Saint Louis University Medical Center,
Missouri 63110-0250.
AN - 8256742
AU - Labovitz, A. J.
AU - Camp, A.
AU - Castello, R.
AU - Martin, T. J.
AU - Ofili, E. O.
AU - Rickmeyer, N.
AU - Vaughn, M.
AU - Gomez, C. R.
DA - Dec 15
DO - 10.1016/0002-9149(93)90195-i
DP - NLM
ET - 1993/12/15
IS - 18
KW - Adolescent
Adult
Aged
Aged, 80 and over
Aging/physiology
Brain Ischemia/*diagnostic imaging/etiology/physiopathology
Female
Humans
Ischemic Attack, Transient/diagnostic imaging
Male
Middle Aged
LA - eng
N1 - Labovitz, A J
Camp, A
Castello, R
Martin, T J
Ofili, E O
Rickmeyer, N
Vaughn, M
Gomez, C R
Journal Article
United States
Am J Cardiol. 1993 Dec 15;72(18):1448-52. doi: 10.1016/0002-9149(93)90195-i.
PY - 1993
SN - 0002-9149 (Print)
0002-9149
SP - 1448-52
ST - Usefulness of transesophageal echocardiography in unexplained cerebral
ischemia
T2 - Am J Cardiol
TI - Usefulness of transesophageal echocardiography in unexplained cerebral
ischemia
VL - 72
ID - 2618
ER -
TY - JOUR
AB - BACKGROUND: Evidence on the relationship between left atrial dimension and
cardiovascular events is inconclusive. We explored the association between left
atrial dimension and stroke and all-cause death in an ethnic Chinese population.
METHODS: We recruited 1,937 subjects undertaking echocardiographic examination
without prior atrial fibrillation/stroke in the Chin-Shan Community Cardiovascular
Cohort study. Left atrial dimension indexed by body mass index was used as left
atrial dimension index (LADI) for analysis. The end points were stroke and all-
cause death. A multivariate Cox regression analysis was used to estimate the
relative risks between participants stratified by tertile of LADI within each
gender. RESULTS: During a median follow-up of 11.9 years, 21,733 person-years were
accrued and 114 subjects with stroke and 364 all-cause deaths were identified. The
adjusted relative risk of stroke was 2.44 (95% CI, 1.11 to 5.36, P for trend =
0.029) among women in the upper tertile of LADI compared with women in the lower
tertile of LADI. Further adjusting for left ventricular mass index attenuated the
relationship of LADI to stroke (adjusted relative risk 2.11, 95% CI, 0.88 to 5.02,
P for trend = 0.09). In men, tertile of LADI was not associated with stroke. LADI
was not associated with risk of all-cause death in both genders. CONCLUSIONS: We
found an association between increased LADI and incident stroke in women but not in
men in this ethnic Chinese population. LADI was not associated with all-cause death
in both genders.
AD - Cardiovascular Center, Far Eastern Memorial Hospital, Taiwan.
AN - 21988172
AU - Lai, C. L.
AU - Chien, K. L.
AU - Hsu, H. C.
AU - Su, T. C.
AU - Chen, M. F.
AU - Lee, Y. T.
DA - Nov
DO - 10.1111/j.1540-8175.2011.01489.x
DP - NLM
ET - 2011/10/13
IS - 10
J2 - Echocardiography (Mount Kisco, N.Y.)
KW - Adult
Aged
Aged, 80 and over
Asian Continental Ancestry Group/statistics & numerical data
Atrial Fibrillation/*diagnostic imaging/*mortality
Cohort Studies
Comorbidity
Echocardiography/methods/*statistics & numerical data
Female
Heart Atria/*diagnostic imaging
Humans
Middle Aged
Organ Size
Prevalence
Prognosis
Risk Assessment
Risk Factors
Stroke/*diagnostic imaging/*mortality
Survival Analysis
Survival Rate
Taiwan/epidemiology
Young Adult
LA - eng
N1 - 1540-8175
Lai, Chao-Lun
Chien, Kuo-Liong
Hsu, Hsiu-Ching
Su, Ta-Chen
Chen, Ming-Fong
Lee, Yuan-Teh
Journal Article
United States
Echocardiography. 2011 Nov;28(10):1054-60. doi: 10.1111/j.1540-8175.2011.01489.x.
Epub 2011 Oct 11.
PY - 2011
SN - 0742-2822
SP - 1054-60
ST - Left atrial dimension and risk of stroke in women without atrial
fibrillation: the Chin-Shan Community Cardiovascular Cohort study
T2 - Echocardiography
TI - Left atrial dimension and risk of stroke in women without atrial
fibrillation: the Chin-Shan Community Cardiovascular Cohort study
VL - 28
ID - 2483
ER -
TY - JOUR
AB - OBJECTIVE: To evaluate the effects of application of bilateral internal
mammary artery grafts in coronary artery by pass grafting (CABG). METHODS: From
Jan. 1998 to Mar. 2001, 51 patients with coronary arteriosclerotic cardiopathy, all
males, aged 36 - 65 (average 49.9 years), underwent coronary artery bypass grafting
with bilateral internal mammary artery grafts. The pathologic change involved three
branches of coronary artery in 48 cases and involved the left main trunk in 3
cases. 37 patients had the history of myocardial infarction. Four cases were
complicated by left ventricular aneurysm. 47 cases were operated upon on-pump and 4
off-pump. Left ventricular aneurysmectomy was done in 4 patients and coronary
endarterectomy in 1 patient. The patterns of anastomosis were as follows: right
internal mammary artery (RIMA) to left anterior descending artery (LAD) and left
internal mammary artery (LIMA) to obtuse marginal (OM) in 39 cases, LIMA to LAD and
RIMA to right coronary artery (RCA) in 9 cases, and LIMA to LAD and RIMA to OM in 3
cases. Gastroepiploic artery and left radical artery were used in other bypass
grafting. The average number of grafts used for each case was 3. RESULTS: There
were 3 early operative deaths, with an early operative mortality rate of 5.9%. One
patient died of low output syndrome due to perioperative myocardial infection, 1
patient died of refractory arrhythmia, and 1 patient died of cerebral accident 40
days after operation. Intraaortic balloon pump was used in 4 cases post-
operatively. Mediastinal infection occurred in 2 patients. The patients were
followed up for 2 to 39 months (average 15.5 months). During the follow-up, no
angina pectoris occurred and ultrasonography showed that the bilateral internal
mammary artery grafts were unobstructed in all patients. CONCLUSION: Bilateral
internal mammary artery grafts can be applied effectively in CABG with a good
short-term effect, especially for young patients.
AD - Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical
AN - 12509904
AU - Lai, Y.
AU - Huang, F.
AU - Yang, J.
AU - Xu, C.
AU - Wu, Q.
DA - Nov 10
DP - NLM
ET - 2003/01/03
IS - 21
J2 - Zhonghua yi xue za zhi
KW - Adult
Aged
Coronary Artery Bypass/*methods
Coronary Artery Disease/mortality/*surgery
Follow-Up Studies
Humans
*Internal Mammary-Coronary Artery Anastomosis
Male
Middle Aged
Survival Rate
Treatment Outcome
LA - chi
N1 - Lai, Yongqiang
Huang, Fangjiong
Yang, Jinfei
Xu, Chunlei
Wu, Qiang
English Abstract
Journal Article
China
Zhonghua Yi Xue Za Zhi. 2002 Nov 10;82(21):1454-6.
PY - 2002
SN - 0376-2491 (Print)
0376-2491
SP - 1454-6
ST - [Application of bilateral internal mammary artery in coronary artery bypass
grafting]
T2 - Zhonghua Yi Xue Za Zhi
TI - [Application of bilateral internal mammary artery in coronary artery bypass
grafting]
VL - 82
ID - 3115
ER -
TY - JOUR
AB - BACKGROUND: Dual-chamber (atrioventricular) and single-chamber (ventricular)
pacing are alternative treatment approaches for sinus-node dysfunction that causes
clinically significant bradycardia. However, it is unknown which type of pacing
results in the better outcome. METHODS: We randomly assigned a total of 2010
patients with sinus-node dysfunction to dual-chamber pacing (1014 patients) or
ventricular pacing (996 patients) and followed them for a median of 33.1 months.
The primary end point was death from any cause or nonfatal stroke. Secondary end
points included the composite of death, stroke, or hospitalization for heart
failure; atrial fibrillation; heart-failure score; the pacemaker syndrome; and the
quality of life. RESULTS: The incidence of the primary end point did not differ
significantly between the dual-chamber group (21.5 percent) and the ventricular-
paced group (23.0 percent, P=0.48). In patients assigned to dual-chamber pacing,
the risk of atrial fibrillation was lower (hazard ratio, 0.79; 95 percent
confidence interval, 0.66 to 0.94; P=0.008), and heart-failure scores were better
(P<0.001). The differences in the rates of hospitalization for heart failure and of
death, stroke, or hospitalization for heart failure were not significant in
unadjusted analyses but became marginally significant in adjusted analyses. Dual-
chamber pacing resulted in a small but measurable increase in the quality of life,
as compared with ventricular pacing. CONCLUSIONS: In sinus-node dysfunction, dual-
chamber pacing does not improve stroke-free survival, as compared with ventricular
pacing. However, dual-chamber pacing reduces the risk of atrial fibrillation,
reduces signs and symptoms of heart failure, and slightly improves the quality of
life. Overall, dual-chamber pacing offers significant improvement as compared with
ventricular pacing.
AD - Division of Cardiology, Mount Sinai Medical Center, and the University of
Miami School of Medicine, Miami Beach, Fla, USA. glamas@msmc.com
AN - 12063369
AU - Lamas, G. A.
AU - Lee, K. L.
AU - Sweeney, M. O.
AU - Silverman, R.
AU - Leon, A.
AU - Yee, R.
AU - Marinchak, R. A.
AU - Flaker, G.
AU - Schron, E.
AU - Orav, E. J.
AU - Greer, S.
AU - McAnulty, J.
AU - Ellenbogen, K.
AU - Ehlert, F.
AU - Freedman, R. A.
AU - Estes, N. A., 3rd
AU - Greenspon, A.
AU - Goldman, L.
DA - Jun 13
DO - 10.1056/NEJMoa013040
DP - NLM
ET - 2002/06/14
IS - 24
KW - Aged
Arrhythmia, Sinus/complications/*therapy
Female
Humans
Male
Pacemaker, Artificial/adverse effects
Quality of Life
Stroke/etiology
Stroke Volume
LA - eng
N1 - 1533-4406
Lamas, Gervasio A
Lee, Kerry L
Sweeney, Michael O
Silverman, Russell
Leon, Angel
Yee, Raymond
Marinchak, Roger A
Flaker, Greg
Schron, Eleanor
Orav, E John
Hellkamp, Anne S
Greer, Stephen
McAnulty, John
Ellenbogen, Kenneth
Ehlert, Frederick
Freedman, Roger A
Estes, N A Mark 3rd
Greenspon, Arnold
Goldman, Lee
Mode Selection Trial in Sinus-Node Dysfunction
Clinical Trial
Comparative Study
Journal Article
Multicenter Study
United States
N Engl J Med. 2002 Jun 13;346(24):1854-62. doi: 10.1056/NEJMoa013040.
PY - 2002
SN - 0028-4793
SP - 1854-62
ST - Ventricular pacing or dual-chamber pacing for sinus-node dysfunction
T2 - N Engl J Med
TI - Ventricular pacing or dual-chamber pacing for sinus-node dysfunction
VL - 346
ID - 2453
ER -
TY - JOUR
AB - The management of arrhythmias in elderly patients with congestive heart
failure, including atrial fibrillation, ventricular tachyarrhythmias, and
bradyarrhythmias, is described. Patients with atrial fibrillation can be treated
with rate control anticoagulation for stroke prevention or by attempt at
cardioversion and maintenance of sinus rhythm. Elderly patients remaining in atrial
fibrillation benefit from anticoagulation provided that no contraindication exists.
In patients surviving malignant ventricular arrhythmias, defibrillator implantation
is beneficial in elderly patients with heart failure. Prognosis and treatment of
nonsustained arrhythmias depends on the presence of underlying cardiac
abnormalities. In the healthy elderly population, treatment is not indicated. In
patients with coronary artery disease, decreased ejection fraction, and
nonsustained ventricular tachycardia, electrophysiology can further stratify risk,
and defibrillator implantation can improve survival if arrhythmias are induced.
This benefit is as great in elderly patients as in younger patients. Symptomatic
bradycardias are increasingly common with advancing age. Symptoms are improved with
pacing, with maximum benefit from physiologic rather than ventricular pacing.
Although the elderly population poses a unique challenge when faced with
arrhythmias, an active approach not only saves lives but also reduces morbidity.
AD - Department of Medicine, Yale University School of Medicine, New Haven,
Connecticut 06520, USA.
AN - 10918649
AU - Lampert, R.
DA - Aug
DO - 10.1016/s0749-0690(05)70030-6
DP - NLM
ET - 2000/08/05
IS - 3
J2 - Clinics in geriatric medicine
KW - Age Factors
Aged
Atrial Fibrillation/epidemiology/*etiology/*therapy
Bradycardia/epidemiology/*etiology/*therapy
Humans
Incidence
Prevalence
Prognosis
Risk Factors
Tachycardia, Ventricular/epidemiology/*etiology/*therapy
LA - eng
N1 - Lampert, R
Ezekowitz, M D
Journal Article
Review
United States
Clin Geriatr Med. 2000 Aug;16(3):593-618. doi: 10.1016/s0749-0690(05)70030-6.
PY - 2000
SN - 0749-0690 (Print)
0749-0690
SP - 593-618
ST - Management of arrythmias
T2 - Clin Geriatr Med
TI - Management of arrythmias
VL - 16
ID - 2412
ER -
TY - JOUR
AB - BACKGROUND: Arterial stiffness is a strong predictor of cardiovascular events
and particularly of stroke. A likely explanation is the development of
atherosclerotic lesions at the carotid level, favored by increased local stiffness.
Another possibility involves cardiac consequences of aortic stiffness and
particularly left atrial dilatation with its subsequent risk of atrial fibrillation
(AF) and cerebral embolism. AIMS: The present study investigated the link between
arterial stiffness, pulse pressure and left atrial size, a determinant of AF risk.
METHODS: Arterial stiffness was determined from pulse wave velocity (PWV) and pulse
pressure (PP). Left atrial size was also measured. Several potential confounders
were taken into account including indices of ventricular remodeling and diastolic
function (estimated by NT-Pro brain natriuretic peptide (NT-proBNP) levels).
RESULTS: Three-hundred and ten hypertensive patients, aged 53 +/- 13 years, were
included. Mean 24-h blood pressure (BP) was 154 +/- 20 over 93 +/- 13 mmHg.
Significant relationships were found between left atrial diameter (LAD) and PWV
(r=0.27, P<0.001) and between LAD and 24-h PP (r=0.32, P<0.001). LAD was also
correlated significantly, although not always tightly, with left ventricular
dimensions, geometry and NT-proBNP. In two different multivariate models, LAD
remained significantly correlated with PWV or with 24-h PP, independently of
classical determinants like age, gender, body mass index, ventricular remodeling
(i.e. dimensions and geometry) and filling pressure. CONCLUSION: These results led
us to propose AF as a new possible pathophysiological link between arterial
stiffness and stroke. These results also emphasize the cardiac consequences of
arterial stiffness which can fuel a new approach to AF prevention.
AD - Service de cardiologie, Hôpital de la Croix-Rousse, Lyon, France.
pierrelantelme@hotmail.com
AN - 18391871
AU - Lantelme, P.
AU - Laurent, S.
AU - Besnard, C.
AU - Bricca, G.
AU - Vincent, M.
AU - Legedz, L.
AU - Milon, H.
DA - Jan
DO - 10.1016/s1875-2136(08)70253-5
DP - NLM
ET - 2008/04/09
IS - 1
KW - Adult
Aged
Atrial Fibrillation/blood/diagnostic imaging/*etiology/physiopathology
Biomarkers/blood
*Blood Pressure
Carotid Artery, Common/*physiopathology
Diastole
Elasticity
Female
Femoral Artery/*physiopathology
Heart Ventricles/diagnostic imaging
Humans
Hypertension/blood/complications/diagnostic imaging/*physiopathology
Male
Middle Aged
Pulsatile Flow
Risk Factors
Stroke/blood/diagnostic imaging/*etiology/physiopathology
Ultrasonography
LA - eng
N1 - Lantelme, P
Laurent, S
Besnard, C
Bricca, G
Vincent, M
Legedz, L
Milon, H
Journal Article
Netherlands
Arch Cardiovasc Dis. 2008 Jan;101(1):35-40. doi: 10.1016/s1875-2136(08)70253-5.
PY - 2008
SN - 1875-2136 (Print)
1875-2128
SP - 35-40
ST - Arterial stiffness is associated with left atrial size in hypertensive
patients
TI - Arterial stiffness is associated with left atrial size in hypertensive
patients
VL - 101
ID - 2500
ER -
TY - JOUR
AB - Epidemiological studies suggest that VVI pacing is associated with a higher
risk of embolic complications than atrial or dual chamber pacing. However, no
studies have been performed on pacemaker patients admitted to a neurological
department with a cerebral embolism. The authors report the cases of 8 patients (6
men and 2 women) with an average age of 74 years and having the following
characteristics: 1) a cerebral embolism, 2) a permanent cardiac pacemaker (7 VVI
and 1 DDD mode). The average delay between implantation of the pacemaker and the
neurological complication was 31 months. Cardiological investigations at the time
of admission showed: a clinically evident cause of cardiac embolism in 3 cases (2
with VVI and 1 with DDD pacing); paroxysmal or permanent atrial fibrillation in 4
cases with VVI pacing at the time of the embolic event (in only one case at the
time of implantation); various echocardiographic abnormalities in 6 of the 7
patients who underwent this examination, mainly left atrial dilatation (6/7),
septal wall motion abnormalities in all related to ventricular pacing and
unexplained left ventricular dilatation in 2 patients with VVI pacemakers. These
results suggest that although the etiology of cerebral embolism was probably
multifactorial in some patients, VVI packing probably a predisposing role, though
not the only cause, and could be considered to be an embolic risk factor as
suggested by previous epidemiological studies. These preliminary retrospective data
should be interpreted cautiously taking into account the small population size.
Prospective studies on pacemaker patients with cerebral embolism are required.
AD - Service de cardiologie, CHU Pitié-Salpêtrière, Paris.
AN - 1300952
AU - Lascault, G.
AU - Dürr, A.
AU - Juillard, J. B.
AU - Thomas, D.
AU - Frank, R.
AU - Gautier, J. C.
AU - Grosgogeat, Y.
DA - Nov
DP - NLM
ET - 1992/11/01
IS - 11
KW - Aged
Aged, 80 and over
Cardiac Pacing, Artificial/*adverse effects/methods
Causality
Echocardiography
Female
Heart Block/therapy
Humans
Intracranial Embolism and Thrombosis/epidemiology/*etiology
Male
Risk Factors
LA - fre
N1 - Lascault, G
Dürr, A
Juillard, J B
Thomas, D
Frank, R
Gautier, J C
Grosgogeat, Y
English Abstract
Journal Article
Review
France
Arch Mal Coeur Vaiss. 1992 Nov;85(11):1527-31.
OP - La stimulation cardiaque VVI: cause ou facteur de risque d'embolies
cérébrales?
PY - 1992
SN - 0003-9683 (Print)
0003-9683
SP - 1527-31
ST - [VVI mode cardiac pacing: cause or risk factor of cerebral embolism?]
TI - [VVI mode cardiac pacing: cause or risk factor of cerebral embolism?]
VL - 85
ID - 2888
ER -
TY - JOUR
AB - A 20-year-old Hispanic woman presented to the emergency department
complaining of six months of progressive dyspnea on exertion associated with
intermittent palpitations. Her only past medical history was a stillbirth at 32
weeks gestation about two years ago. Her vital signs in the emergency department
were a heart rate of 120 beats/minute, a blood pressure of 145/86 mmHg, and an
arterial oxygen saturation of 98 percent with her breathing air. Significant
laboratory values included a blood hemoglobin of 14.5 gm/dL, a hematocrit of 49
percent, a brain naturetic peptide (BNP) level of 177 pg/mL, a D-dimer level of 330
ng/ml, a prothrombin time of 12.85 s with an INR of 1.2, and a partial
thromboplastin time of 45.7s. Urine pregnancy test was positive, and serum beta-
human chorionic gonadotropin level was 81 MIU/mL consistent with a fetus of 3-4
weeks gestational age. An electrocardiogram was recorded.
AD - House Officer, Department of Medicine, Louisiana State University Health
Sciences Center, New Orleans.
Faculty, Department of Medicine, Louisiana State University Health Sciences Center,
New Orleans.
Resident in the Department of Cardiology at Mt. Sinai Medical Center in Queens, New
York.
AN - 25978754
AU - Lathia, V. N.
AU - Haas, J. R.
AU - Jaligam, V. R.
AU - Mickman, C. T.
AU - Lo, B. P.
AU - Glancy, D. L.
DA - Jan-Feb
DP - NLM
ET - 2015/05/16
IS - 1
J2 - The Journal of the Louisiana State Medical Society : official organ of the
Louisiana State Medical Society
KW - Adult
Cardiomegaly/etiology/*physiopathology
Dyspnea/etiology/*physiopathology
Female
Humans
Pregnancy
Pregnancy Complications, Cardiovascular/etiology/*physiopathology
Pulmonary Embolism/complications/*physiopathology
Tachycardia, Sinus/etiology/*physiopathology
LA - eng
N1 - Lathia, Viral N
Haas, John R
Jaligam, Vijayendra R
Mickman, Carl T
Lo, Betty P
Glancy, D Luke
Case Reports
Journal Article
United States
J La State Med Soc. 2015 Jan-Feb;167(1):29-31. Epub 2015 Feb 15.
PY - 2015
SN - 0024-6921 (Print)
0024-6921
SP - 29-31
ST - ECG Case of the Month: ECG in a 20-Year-Old Woman with Dyspnea. Sinus
tachycardia (104 beats/minute), slight right axis deviation of the QRS (+92°), an
R/S ratio greater than 1 in lead V1 with ST depression and T wave inversion in
leads V1 - V4, and a prominent S wave in lead I, Q wave in lead III, and inverted T
wave in lead III(S1 Q3 T3). These findings suggest right ventricular hypertrophy or
strain and are consistent with pulmonary emboli
T2 - J La State Med Soc
TI - ECG Case of the Month: ECG in a 20-Year-Old Woman with Dyspnea. Sinus
tachycardia (104 beats/minute), slight right axis deviation of the QRS (+92°), an
R/S ratio greater than 1 in lead V1 with ST depression and T wave inversion in
leads V1 - V4, and a prominent S wave in lead I, Q wave in lead III, and inverted T
wave in lead III(S1 Q3 T3). These findings suggest right ventricular hypertrophy or
strain and are consistent with pulmonary emboli
VL - 167
ID - 2992
ER -
TY - JOUR
AB - BACKGROUND: Atrial-based pacing is associated with lower risk of atrial
fibrillation (AF) in sick sinus syndrome compared with ventricular pacing;
nevertheless, the impact of site and rate of atrial pacing on progression of AF
remains unclear. We evaluated whether long-term atrial pacing at the right atrial
(RA) appendage versus the low RA septum with (ON) or without (OFF) a continuous
atrial overdrive pacing algorithm can prevent the development of persistent AF.
METHODS AND RESULTS: We randomized 385 patients with paroxysmal AF and sick sinus
syndrome in whom a pacemaker was indicated to pacing at RA appendage ON (n=98), RA
appendage OFF (n=99), RA septum ON (n=92), or RA septum OFF (n=96). The primary
outcome was the occurrence of persistent AF (AF documented at least 7 days apart or
need for cardioversion). Demographic data were homogeneous across both pacing site
(RA appendage/RA septum) and atrial overdrive pacing (ON/OFF). After a mean follow-
up of 3.1 years, persistent AF occurred in 99 patients (25.8%; annual rate of
persistent AF, 8.3%). Alternative site pacing at the RA septum versus conventional
RA appendage (hazard ratio=1.18; 95% confidence interval, 0.79-1.75; P=0.65) or
continuous atrial overdrive pacing ON versus OFF (hazard ratio=1.17; 95% confidence
interval, 0.79-1.74; P=0.69) did not prevent the development of persistent AF.
CONCLUSIONS: In patients with paroxysmal AF and sick sinus syndrome requiring
pacemaker implantation, an alternative atrial pacing site at the RA septum or
continuous atrial overdrive pacing did not prevent the development of persistent
AF. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. UNIQUE
IDENTIFIER: NCT00419640.
AD - Cardiology Division, Department of Medicine, University of Hong Kong, Queen
Mary Hospital, Hong Kong SAR, China.
AN - 23868858
AU - Lau, C. P.
AU - Tachapong, N.
AU - Wang, C. C.
AU - Wang, J. F.
AU - Abe, H.
AU - Kong, C. W.
AU - Liew, R.
AU - Shin, D. G.
AU - Padeletti, L.
AU - Kim, Y. H.
AU - Omar, R.
AU - Jirarojanakorn, K.
AU - Kim, Y. N.
AU - Chen, M. C.
AU - Sriratanasathavorn, C.
AU - Munawar, M.
AU - Kam, R.
AU - Chen, J. Y.
AU - Cho, Y. K.
AU - Li, Y. G.
AU - Wu, S. L.
AU - Bailleul, C.
AU - Tse, H. F.
DA - Aug 13
DP - NLM
ET - 2013/07/23
IS - 7
J2 - Circulation
KW - Aged
Aged, 80 and over
Algorithms
Atrial Appendage
Atrial Fibrillation/etiology/*prevention & control/therapy
Disease Progression
Female
Heart Septum
Humans
Male
Middle Aged
Prospective Studies
Sick Sinus Syndrome/*complications/therapy
Stroke/etiology
Treatment Failure
atrial fibrillation
cardiac pacing, artificial
sick sinus syndrome
LA - eng
N1 - 1524-4539
Lau, Chu-Pak
Tachapong, Ngarmukos
Wang, Chun-Chieh
Wang, Jing-Feng
Abe, Haruhiko
Kong, Chi-Woon
Liew, Reginald
Shin, Dong-Gu
Padeletti, Luigi
Kim, You-Ho
Omar, Razali
Jirarojanakorn, Kreingkrai
Kim, Yoon-Nyun
Chen, Mien-Cheng
Sriratanasathavorn, Charn
Munawar, Muhammad
Kam, Ruth
Chen, Jan-Yow
Cho, Yong-Keun
Li, Yi-Gang
Wu, Shu-Lin
Bailleul, Christophe
Tse, Hung-Fat
Septal Pacing for Atrial Fibrillation Suppression Evaluation Study Group
Comparative Study
Journal Article
Multicenter Study
United States
Circulation. 2013 Aug 13;128(7):687-93. doi: 10.1161/CIRCULATIONAHA.113.001644.
Epub 2013 Jul 18.
PY - 2013
SN - 0009-7322
SP - 687-93
ST - Prospective randomized study to assess the efficacy of site and rate of
atrial pacing on long-term progression of atrial fibrillation in sick sinus
syndrome: Septal Pacing for Atrial Fibrillation Suppression Evaluation (SAFE) Study
T2 - Circulation
TI - Prospective randomized study to assess the efficacy of site and rate of
atrial pacing on long-term progression of atrial fibrillation in sick sinus
syndrome: Septal Pacing for Atrial Fibrillation Suppression Evaluation (SAFE) Study
VL - 128
ID - 2626
ER -
TY - JOUR
AB - PURPOSE: In an earlier report, we documented the incidence and impact of
aortic branch compromise complicating acute aortic dissection (AD) over a 21-year
interval (1965-1986). In the current study, management of peripheral vascular
complications (PVCs) of AD over the past decade was reviewed. METHODS: Medical
records of patients treated for AD over the interval January 1, 1990, to December
31, 1999, were reviewed. Patients with branch compromise confirmed with radiography
or operation and patients with spinal cord ischemia that was based on results of a
physical examination defined the study group. Comparisons between subgroups with
and without PVC over a 30-year interval were analyzed with the chi(2) test.
RESULTS: A total of 187 patients (101 proximal and 86 distal) were treated for AD
over the study interval. A total of 53 (28%) of these patients had clinical
evidence of organ or limb malperfusion (7 cerebral, 3 upper extremity, 5 spinal
cord, 11 mesenteric, 12 renal, and 24 lower extremity [sites inclusive]), and one
of three (17 patients) of these underwent specific peripheral vascular
intervention. The remaining 65% (36) of the PVC group had complete or partial
malperfusion resolution after central aortic therapy (medical or surgical) alone.
Open techniques for treating PVC included aortic fenestration (9), femorofemoral
grafting (2), and aortofemoral grafting (1). All had favorable outcomes with no
mortality. Endovascular procedures in five patients included abdominal aortic
fenestration (3) or stenting of the renal (2), mesenteric (2), and iliac (1)
arteries with clinical success in three patients and two deaths. The in-hospital
mortality rate for the entire group of 187 patients was 18% (15% for proximal
aortic operation, 8% in medically treated patients). The presence of aortic branch
compromise was not a statistically significant predictor of the patient mortality
rate (23% with and 16% without; P =.26). Overall mortality rate in the current
study (18% vs 37%; P =.000006) and the mortality rate with PVC (23% vs 51%; P
=.001), in particular with mesenteric ischemia (36% vs 87%; P =.026), decreased
significantly when compared with prior experience. CONCLUSIONS: The overall
mortality rate from AD during the past decade has decreased significantly. Similar
trends were noted in patients with PVCs, a previously identified high-risk
subgroup. Increased awareness and prompt, specific management of PVCs, in
particular when visceral ischemia is present, have contributed to improved outcomes
in patients with AD.
AD - Division of Vascular Surgery and the Thoracic Aortic Center, Massachusetts
General Hospital, and Department of Surgery, Harvard Medical School, Boston, Mass
02114, USA.
AN - 11389416
AU - Lauterbach, S. R.
AU - Cambria, R. P.
AU - Brewster, D. C.
AU - Gertler, J. P.
AU - Lamuraglia, G. M.
AU - Isselbacher, E. M.
AU - Hilgenberg, A. D.
AU - Moncure, A. C.
DA - Jun
DO - 10.1067/mva.2001.115377
DP - NLM
ET - 2001/06/05
IS - 6
J2 - Journal of vascular surgery
KW - Acute Disease
Adult
Aged
Aged, 80 and over
Aneurysm, Dissecting/*complications/diagnostic imaging/surgery
Angiography
Aortic Aneurysm/*complications/diagnostic imaging/surgery
Arterial Occlusive Diseases/diagnostic imaging/*etiology/*surgery
Cohort Studies
Female
Follow-Up Studies
Humans
Iliac Artery
Ischemia/diagnosis/etiology/surgery
Leg/blood supply
Male
Mesenteric Arteries
Middle Aged
Peripheral Vascular Diseases/diagnostic imaging/etiology/*surgery
Registries
Renal Artery
Survival Rate
Treatment Outcome
Vascular Surgical Procedures/*methods/mortality
LA - eng
N1 - Lauterbach, S R
Cambria, R P
Brewster, D C
Gertler, J P
Lamuraglia, G M
Isselbacher, E M
Hilgenberg, A D
Moncure, A C
Comparative Study
Journal Article
United States
J Vasc Surg. 2001 Jun;33(6):1185-92. doi: 10.1067/mva.2001.115377.
PY - 2001
SN - 0741-5214 (Print)
0741-5214
SP - 1185-92
ST - Contemporary management of aortic branch compromise resulting from acute
aortic dissection
T2 - J Vasc Surg
TI - Contemporary management of aortic branch compromise resulting from acute
aortic dissection
VL - 33
ID - 3097
ER -
TY - JOUR
AB - BACKGROUND: Heart transplantation remains a resource-intensive therapy for
children. However, data regarding change in costs over time are scarce. We tested
the hypothesis that hospital charges for pediatric heart transplant
hospitalizations would increase from 1997 to 2006 and assessed factors associated
with hospital charges. METHODS: A retrospective analysis of the Healthcare Cost and
Utilization Project Kids' Inpatient Database was performed on admissions
surrounding heart transplantation for the years 1997, 2000, 2003, and 2006. The
database is a nationwide sampling of pediatric hospital discharges and is weighted
to provide national estimates. RESULTS: There were 353 (95% confidence interval,
201-505) pediatric heart transplants in 1997 and 355 (95% confidence interval, 226-
485) in 2006. Mean hospital charges increased from $279,399 in 1997 to $451,738 in
2006 (p < 0.001). This increase was similar to that observed for other pediatric
surgical diseases. Increases also occurred in morbidities, including pulmonary
hypertension (p = 0.04) and sepsis (p = 0.04), and in the use of extracorporeal
membrane oxygenation (p = 0.03). On multivariable analysis, greater hospital
charges were associated with later calendar year (p = 0.001), stroke (p = 0.03),
sepsis (p = 0.001), renal failure (p = 0.008), arrhythmia (p = 0.03), and use of
extracorporeal membrane oxygenation (p < 0.001) and ventricular assist device (p <
0.001). CONCLUSIONS: From 1997 to 2006, mean charges for pediatric heart transplant
hospitalizations increased by > $170,000 (160%). Although greater morbidities in
the later years of the study potentially contributed to increased charges, later
calendar year was independently associated with increased charges. The changes in
charges for heart transplant are similar to the increases seen in other surgical
procedures. Ongoing study of management strategies is needed to determine cost-
effective therapies for this complex group of patients.
AD - Division of Pediatric Cardiology, Seattle Children's Hospital, Seattle, WA,
USA. sabrina.law@seattlechildrens.org
AN - 22306440
AU - Law, S. P.
AU - Kim, J. J.
AU - Decker, J. A.
AU - Price, J. F.
AU - Cabrera, A. G.
AU - Graves, D. E.
AU - Morales, D. L.
AU - Heinle, J. S.
AU - Denfield, S. W.
AU - Dreyer, W. J.
AU - Rossano, J. W.
DA - May
DO - 10.1016/j.healun.2011.12.008
DP - NLM
ET - 2012/02/07
IS - 5
J2 - The Journal of heart and lung transplantation : the official publication of
the International Society for Heart Transplantation
KW - Adolescent
Child
Child, Preschool
Comorbidity
Female
Heart Transplantation/*economics
Hospital Charges/statistics & numerical data/*trends
Hospitalization/*economics
Hospitals, Pediatric/*economics
Humans
Infant
Male
Sepsis/epidemiology
Stroke/epidemiology
United States
Young Adult
LA - eng
N1 - 1557-3117
Law, Sabrina P
Kim, Jeffrey J
Decker, Jamie A
Price, Jack F
Cabrera, Antonio G
Graves, Daniel E
Morales, David L S
Heinle, Jeffrey S
Denfield, Susan W
Dreyer, William J
Rossano, Joseph W
Journal Article
United States
J Heart Lung Transplant. 2012 May;31(5):485-91. doi: 10.1016/j.healun.2011.12.008.
Epub 2012 Feb 4.
PY - 2012
SN - 1053-2498
SP - 485-91
ST - Hospital charges for pediatric heart transplant hospitalizations in the
United States from 1997 to 2006
T2 - J Heart Lung Transplant
TI - Hospital charges for pediatric heart transplant hospitalizations in the
United States from 1997 to 2006
VL - 31
ID - 2686
ER -
TY - JOUR
AB - Atrial fibrillation (AF) is an independent risk factor for ischemic stroke.
In patients with AF, cardioembolias present about 10% of ischemic strokes.
Transesophageal echocardiography is an ideal instrument for diagnostics of
intracardiac thrombi. An aim of the study was to find the high risk markers for
stroke in patients with AF of non-valvular origin. The patients have been divided
into 2 groups with and without stroke in anamnesis. To search for stroke dependence
of clinical and echocardiographic high risk markers, the data were analyzed using
Poly Analyst Power statistical package. In the group of the patients with stroke in
the anamnesis, echocardiographic markers for high risk of thromboembolia occurred
significantly more frequently. Thrombi in the left atrial or its appendage were
registered in 12.5% patients without stroke in anamnesis and in 31% of those, who
survived stroke. The independent risk factors for stroke were age, AF duration,
left ventricular ejection fraction, diabetes mellitus and arterial hypertension.
AN - 15285630
AU - Lazebnik, L. B.
AU - Zamiro, T. N.
AU - Bychkova, O. P.
AU - Li, E. D.
AU - Kashevskaia, O. P.
AU - Prilutskaia, M. A.
DP - NLM
ET - 2004/08/03
IS - 6
J2 - Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
KW - Adult
Age Factors
Aged
Aged, 80 and over
Atrial Fibrillation/*complications/etiology/prevention & control
Female
Heart Diseases/diagnosis
Humans
Male
Middle Aged
Risk Factors
Stroke Volume
Thrombosis/diagnosis
Time Factors
LA - rus
N1 - Lazebnik, L B
Zamiro, T N
Bychkova, O P
Li, E D
Kashevskaia, O P
Prilutskaia, M A
Comparative Study
English Abstract
Journal Article
Russia (Federation)
Zh Nevrol Psikhiatr Im S S Korsakova. 2004;104(6):21-6.
OP - Risk i profilaktika fibrilliatsii predserdiĭ neklapannoĭ étiologii.
PY - 2004
SN - 1997-7298 (Print)
1997-7298
SP - 21-6
ST - [Risk and prevention of atrial fibrillation of non-valvular origin]
T2 - Zh Nevrol Psikhiatr Im S S Korsakova
TI - [Risk and prevention of atrial fibrillation of non-valvular origin]
VL - 104
ID - 2692
ER -
TY - JOUR
AB - A total of 1,250 selective coronary arteriographic procedures were performed
by the percutaneous transfemoral technique. There were no deaths. Local
complications included delayed hemorrhage in 14 patients, peripheral emboli in 2,
and thrombosis in 1. Cerebral complications included fibrin or air emboli in 3 and
dislodgement of a mural thrombus by the catheter in 1. Cardiac complications
included ventricular fibrillation in 11, myocardial infarction in 3, and profound
hypotension in 1. With routine use of a transparent manifold and removal of the
guide wire distal to the arch vessels, no cerebral emboli or myocardial infarctions
have occurred in the last 500 examinations.
AN - 1153757
AU - Lebowitz, W. B.
AU - Lucia, W.
DA - Sep
DO - 10.1148/116.3.545
DP - NLM
ET - 1975/09/01
IS - 3
J2 - Radiology
KW - Adult
Aged
Angiocardiography/*adverse effects/methods
Connecticut
*Coronary Angiography
Coronary Disease/diagnostic imaging/epidemiology
Female
Hemorrhage/*etiology
Humans
Intracranial Embolism and Thrombosis/etiology
Male
Middle Aged
LA - eng
N1 - Lebowitz, W B
Lucia, W
Journal Article
United States
Radiology. 1975 Sep;116(3):545-7. doi: 10.1148/116.3.545.
PY - 1975
SN - 0033-8419 (Print)
0033-8419
SP - 545-7
ST - Complications of selective percutaneous transfemoral coronary arteriography
T2 - Radiology
TI - Complications of selective percutaneous transfemoral coronary arteriography
VL - 116
ID - 2994
ER -
TY - JOUR
AB - IMPORTANCE: Prevention strategies for heart failure are needed. OBJECTIVE: To
determine the efficacy of a screening program using brain-type natriuretic peptide
(BNP) and collaborative care in an at-risk population in reducing newly diagnosed
heart failure and prevalence of significant left ventricular (LV) systolic and/or
diastolic dysfunction. DESIGN, SETTING, AND PARTICIPANTS: The St Vincent's
Screening to Prevent Heart Failure Study, a parallel-group randomized trial
involving 1374 participants with cardiovascular risk factors (mean age, 64.8 [SD,
10.2] years) recruited from 39 primary care practices in Ireland between January
2005 and December 2009 and followed up until December 2011 (mean follow-up, 4.2
[SD, 1.2] years). INTERVENTION: Patients were randomly assigned to receive usual
primary care (control condition; n=677) or screening with BNP testing (n=697).
Intervention-group participants with BNP levels of 50 pg/mL or higher underwent
echocardiography and collaborative care between their primary care physician and
specialist cardiovascular service. MAIN OUTCOMES AND MEASURES: The primary end
point was prevalence of asymptomatic LV dysfunction with or without newly diagnosed
heart failure. Secondary end points included emergency hospitalization for
arrhythmia, transient ischemic attack, stroke, myocardial infarction, peripheral or
pulmonary thrombosis/embolus, or heart failure. RESULTS: A total of 263 patients
(41.6%) in the intervention group had at least 1 BNP reading of 50 pg/mL or higher.
The intervention group underwent more cardiovascular investigations (control, 496
per 1000 patient-years vs intervention, 850 per 1000 patient-years; incidence rate
ratio, 1.71; 95% CI, 1.61-1.83; P<.001) and received more renin-angiotensin-
aldosterone system-based therapy at follow-up (control, 49.6%; intervention, 56.5%;
P=.01). The primary end point of LV dysfunction with or without heart failure was
met in 59 (8.7%) of 677 in the control group and 37 (5.3%) of 697 in the
intervention group (odds ratio [OR], 0.55; 95% CI, 0.37-0.82; P = .003).
Asymptomatic LV dysfunction was found in 45 (6.6%) of 677 control-group patients
and 30 (4.3%) of 697 intervention-group patients (OR, 0.57; 95% CI, 0.37-0.88; P
= .01). Heart failure occurred in 14 (2.1%) of 677 control-group patients and 7
(1.0%) of 697 intervention-group patients (OR, 0.48; 95% CI, 0.20-1.20; P = .12).
The incidence rates of emergency hospitalization for major cardiovascular events
were 40.4 per 1000 patient-years in the control group vs 22.3 per 1000 patient-
years in the intervention group (incidence rate ratio, 0.60; 95% CI, 0.45-0.81; P
= .002). CONCLUSION AND RELEVANCE: Among patients at risk of heart failure, BNP-
based screening and collaborative care reduced the combined rates of LV systolic
dysfunction, diastolic dysfunction, and heart failure. TRIAL REGISTRATION:
clinicaltrials.gov Identifier: NCT00921960.
AD - Chronic Cardiovascular Disease Management Unit, St Vincent's Healthcare
Group/St Michael's Hospital, Dublin, Ireland.
AN - 23821090
AU - Ledwidge, M.
AU - Gallagher, J.
AU - Conlon, C.
AU - Tallon, E.
AU - O'Connell, E.
AU - Dawkins, I.
AU - Watson, C.
AU - O'Hanlon, R.
AU - Bermingham, M.
AU - Patle, A.
AU - Badabhagni, M. R.
AU - Murtagh, G.
AU - Voon, V.
AU - Tilson, L.
AU - Barry, M.
AU - McDonald, L.
AU - Maurer, B.
AU - McDonald, K.
DA - Jul 3
DO - 10.1001/jama.2013.7588
DP - NLM
ET - 2013/07/04
IS - 1
J2 - Jama
KW - Aged
Biomarkers/blood
Cardiology
Cardiovascular Diseases/epidemiology
Diastole
Echocardiography
Emergency Medical Services/statistics & numerical data
Female
Heart Failure/*diagnosis/*prevention & control
Humans
Male
*Mass Screening
Middle Aged
*Patient Care Team
Prevalence
Primary Health Care
Prospective Studies
Risk Factors
Ventricular Dysfunction, Left/*epidemiology
LA - eng
N1 - 1538-3598
Ledwidge, Mark
Gallagher, Joseph
Conlon, Carmel
Tallon, Elaine
O'Connell, Eoin
Dawkins, Ian
Watson, Chris
O'Hanlon, Rory
Bermingham, Margaret
Patle, Anil
Badabhagni, Mallikarjuna R
Murtagh, Gillian
Voon, Victor
Tilson, Leslie
Barry, Michael
McDonald, Laura
Maurer, Brian
McDonald, Kenneth
Journal Article
United States
JAMA. 2013 Jul 3;310(1):66-74. doi: 10.1001/jama.2013.7588.
PY - 2013
SN - 0098-7484
SP - 66-74
ST - Natriuretic peptide-based screening and collaborative care for heart failure:
the STOP-HF randomized trial
T2 - Jama
TI - Natriuretic peptide-based screening and collaborative care for heart failure:
the STOP-HF randomized trial
VL - 310
ID - 3131
ER -
TY - JOUR
AB - BACKGROUND: Although several risk factors for stroke have been reported in
patients with atrial fibrillation (AF), the relation of LV diastolic dysfunction to
stroke is still uncertain in these patients. We evaluated the relationship between
tissue Doppler-derived index, E/E', as well as other clinical and echocardiographic
parameters and ischemic stroke by this cross-sectional study. METHODS: Three
hundred thirty patients with persistent AF who had preserved LV ejection fraction
were included from 6 centers. Clinical data were obtained and standard
transthoracic echocardiography was performed. Patients without a history of
ischemic stroke (n=280) were compared with patients with this complication (n=50).
Potential determinants of ischemic stroke were identified by logistic regression
analyses. RESULTS: In univariate analyses, age, history of hypertension, diabetes
mellitus, hyperlipidemia and symptomatic heart failure, plasma brain natriuretic
peptide (BNP) level, early mitral inflow velocity (E), diastolic mitral annular
velocity (E'), and E/E' ratio were significantly correlated to ischemic stroke.
Multivariate regression analyses identified two significant variables that were
independently associated with ischemic stroke: hypertension (odds ratio=6.03,
p=0.008), and E/E' (odds ratio=1.21, p=0.002). CONCLUSIONS: These findings may have
clinical implications that LV diastolic dysfunction, reflected by E/E', is a
significant determinant of ischemic stroke in AF. A larger prospective data is
needed to confirm the value of E/E' in risk stratification for ischemic stroke in
this population.
AD - Cardiology Division, Yonsei Cardiovascular Center, Yonsei University College
of Medicine, Seoul, Republic of Korea.
AN - 18501379
AU - Lee, S. H.
AU - Choi, S.
AU - Chung, W. J.
AU - Byun, Y. S.
AU - Ryu, S. K.
AU - Pyun, W. B.
AU - Rim, S. J.
DA - Aug 15
DO - 10.1016/j.jns.2008.04.006
DP - NLM
ET - 2008/05/27
IS - 1-2
KW - Aged
Atrial Fibrillation/*complications/diagnostic imaging
Blood Flow Velocity
Cardiac Volume/*physiology
Female
Humans
Hypertension
Male
Middle Aged
Odds Ratio
Regression Analysis
Risk Factors
Ventricular Dysfunction, Left/*diagnostic imaging/physiopathology
LA - eng
N1 - Lee, Sang-Hak
Choi, Seonghoon
Chung, Wook-Jin
Byun, Young-Sup
Ryu, Sung-Kee
Pyun, Wook-Bum
Rim, Se-Joong
Journal Article
Netherlands
J Neurol Sci. 2008 Aug 15;271(1-2):148-52. doi: 10.1016/j.jns.2008.04.006. Epub
2008 May 22.
PY - 2008
SN - 0022-510X (Print)
0022-510x
SP - 148-52
ST - Tissue Doppler index, E/E', and ischemic stroke in patients with atrial
fibrillation and preserved left ventricular ejection fraction
T2 - J Neurol Sci
TI - Tissue Doppler index, E/E', and ischemic stroke in patients with atrial
fibrillation and preserved left ventricular ejection fraction
VL - 271
ID - 2332
ER -
TY - JOUR
AB - BACKGROUND: Procedural results for percutaneous coronary intervention (PCI)
in coronary vessels with chronic total occlusion (CTO) have improved in recent
years, and PCI strategies have moved toward more complete revascularization with
more liberal use of CTO-PCI. However, evidence evaluating CTO-PCI is limited to
observational studies and small clinical trials. METHODS: In this open-label,
multicenter, randomized, noninferiority trial, PCI-eligible patients were assigned
to receive either 1 of 2 strategies: PCI or no PCI for the qualifying de novo CTO
lesion with the option for PCI of obstructive non-CTO lesions at the discretion of
the operator. The primary end point was a composite of death, myocardial
infarction, stroke, or any revascularization. Health-related quality of life was
assessed at baseline and at 1, 6, 12, 24, and 36 months. Because of slow
recruitment, the trial was stopped before completion of the 1284 planned
enrollments. RESULTS: Between March 2010 and September 2016, 834 patients were
randomly assigned to the CTO-PCI (n=417) or no CTO-PCI (n=398) strategy. Among the
patients assigned to the no CTO-PCI strategy, 78 (19.6%) crossed over to receive
staged CTO-PCI within 3 days of randomization. The overall CTO-PCI success rate was
90.6%. Serious nonfatal complications associated with CTO-PCI occurred in 3
patients (1 stroke, 1 cardiac tamponade, and 1 patient with recurrent episodes of
ventricular tachyarrhythmia induced by intracoronary thrombus). Approximately half
of the patients in each group underwent PCI for an average of 1.3 non-CTO lesions,
resulting in a comparable residual SYNTAX score (Synergy Between PCI With TAXUS and
Cardiac Surgery; 3.7±5.4 versus 4.0±5.9, P=0.42) confined to non-CTO vessels.
During a median follow-up of 4.0 years (interquartile range, 2.4 to 5.1 years),
there was no significant difference between the CTO-PCI and the no CTO-PCI
strategies in the incidence of the primary end point (22.3% versus 22.4%, hazard
ratio, 1.03; 95% CI, 0.77 to 1.37; P=0.86). Both CTO-PCI and no CTO-PCI strategy
were associated with significant improvements but without between-group differences
in disease-specific health status that was sustained through 36 months.
CONCLUSIONS: CTO-PCI was feasible with high success rates. There was no difference
in the incidence of major adverse cardiovascular events with CTO-PCI versus no CTO-
PCI, but the study was limited by low power for clinical end points and high
crossover rates between groups. CLINICAL TRIAL REGISTRATION: URL:
https://www.clinicaltrials.gov . Unique identifier: NCT01078051.
AD - Department of Cardiology (S-W.L., P.H.L., J.-M.A., D.-W.P., H.K., S.-J.K.,
Y.-H.K., C.W.L., S.-W.P., S.-J.P.), Center for Medical Research and Information,
University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Biostatistics (S.-C.Y.), Center for Medical Research and Information, University of
Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Department of Applied Statistics, Gachon University, Seongnam, Korea (S.H.).
Department of Cardiology, Keimyung University Dongsan Medical Center, Daegu, Korea
(S.H.H.).
Department of Cardiology, Korea University Guro Hospital, Seoul (S.-W.R.).
Department of Cardiology, The Catholic University of Korea, Daejeon St. Mary's
Hospital (S.-H.H.).
Department of Cardiology, Chungnam National University Hospital, Daejeon, Korea
(S.W.C.).
Department of Cardiology, Kangwon National University Hospital, Chuncheon, Korea
(B.-K.L.).
Department of Cardiology, Soon Chun Hyang University Hospital Bucheon, Korea (N.-
H.L.).
Department of Cardiology, Kangbuk Samsung Medical Center, Seoul, Korea (J.-Y.L.).
Department of Cardiology, Gangneung Asan Hospital, Korea (S.-S.C.).
Department of Cardiology, Dong-A University Hospital, Busan, Korea (M.H.K.).
Department of Cardiology, Chonnam National University Hospital, Gwangju, Korea (Y.-
K.A.).
Department of Cardiology, CHA Bundang Medical Center, Seongnam, Korea (S.W.L.).
Department of Cardiology, Ulsan University Hospital, Korea (S.-G.L.).
Department of Cardiology, Ruby Hall Clinic, Pune, India (S.H.).
Department of Cardiology, Medistra Hospital, Jakarta, Indonesia (T.S.).
Department of Cardiology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand
(W.U.).
Department of Cardiology, Shin Kong Hospital, Taipei, Taiwan (J.J.C.).
Saint Luke's Mid America Heart Institute, Kansas City, MO (D.J.C.).
Department of Cardiology, Tokyo General Hospital, Japan (T.M.).
Toyohashi Heart Center, Aichi, Japan (E.T.).
Department of Cardiology, Hakujikai Memorial Hospital, Tokyo, Japan (Y.A.).
AN - 30813758
AU - Lee, S. W.
AU - Lee, P. H.
AU - Ahn, J. M.
AU - Park, D. W.
AU - Yun, S. C.
AU - Han, S.
AU - Kang, H.
AU - Kang, S. J.
AU - Kim, Y. H.
AU - Lee, C. W.
AU - Park, S. W.
AU - Hur, S. H.
AU - Rha, S. W.
AU - Her, S. H.
AU - Choi, S. W.
AU - Lee, B. K.
AU - Lee, N. H.
AU - Lee, J. Y.
AU - Cheong, S. S.
AU - Kim, M. H.
AU - Ahn, Y. K.
AU - Lim, S. W.
AU - Lee, S. G.
AU - Hiremath, S.
AU - Santoso, T.
AU - Udayachalerm, W.
AU - Cheng, J. J.
AU - Cohen, D. J.
AU - Muramatsu, T.
AU - Tsuchikane, E.
AU - Asakura, Y.
AU - Park, S. J.
DA - Apr 2
DP - NLM
ET - 2019/03/01
IS - 14
J2 - Circulation
KW - Aged
Asia/epidemiology
Chronic Disease
Coronary Occlusion/diagnostic imaging/mortality/*therapy
Drug-Eluting Stents
Female
Humans
Incidence
Male
Middle Aged
*Percutaneous Coronary Intervention/adverse effects/instrumentation/mortality
Quality of Life
Risk Factors
Stroke/epidemiology
Time Factors
Treatment Outcome
*arterial occlusive diseases
*outcome
*percutaneous coronary intervention
*randomized controlled trial
LA - eng
N1 - 1524-4539
Lee, Seung-Whan
Lee, Pil Hyung
Ahn, Jung-Min
Park, Duk-Woo
Yun, Sung-Cheol
Han, Seungbong
Kang, Heejun
Kang, Soo-Jin
Kim, Young-Hak
Lee, Cheol Whan
Park, Seong-Wook
Hur, Seung Ho
Rha, Seung-Woon
Her, Sung-Ho
Choi, Si Wan
Lee, Bong-Ki
Lee, Nae-Hee
Lee, Jong-Young
Cheong, Sang-Sig
Kim, Moo Hyun
Ahn, Young-Keun
Lim, Sang Wook
Lee, Sang-Gon
Hiremath, Shirish
Santoso, Teguh
Udayachalerm, Wasan
Cheng, Jun Jack
Cohen, David J
Muramatsu, Toshiya
Tsuchikane, Etsuo
Asakura, Yasushi
Park, Seung-Jung
Equivalence Trial
Journal Article
Multicenter Study
United States
Circulation. 2019 Apr 2;139(14):1674-1683. doi: 10.1161/CIRCULATIONAHA.118.031313.
PY - 2019
SN - 0009-7322
SP - 1674-1683
ST - Randomized Trial Evaluating Percutaneous Coronary Intervention for the
Treatment of Chronic Total Occlusion
T2 - Circulation
TI - Randomized Trial Evaluating Percutaneous Coronary Intervention for the
Treatment of Chronic Total Occlusion
VL - 139
ID - 2831
ER -
TY - JOUR
AB - AIMS: The present study aimed to determine the frequency and the impact on
clinical outcome of atrial fibrillation (AF) in patients with acute myocardial
infarction (AMI) and left ventricular dysfunction. METHODS AND RESULTS: In the
OPTIMAAL trial, 5477 patients with AMI and signs of left ventricular dysfunction
were included. At baseline, 655 patients (12%) had AF, and 345 (7.2%) developed
new-onset AF during follow-up (2.7 +/- 0.9 years). Older patients, patients with
history of angina and worse Killip class had and developed AF more frequently (P <
0.001). Patients with AF at baseline were at increased risk relative to those
without AF for mortality [adjusted hazard ratio (HR) of 1.32, P = 0.001] and for
stroke (HR 1.77, P < 0.001). New-onset AF was associated with increased subsequent
mortality for the first 30 days following randomization (HR 3.83, P < 0.001) and
the entire trial period (HR 1.82, P < 0.001). Risk of stroke was increased for the
first 30 days (HR 14.6, P < 0.001) and for the whole trial period (HR 2.29, P <
0.001). CONCLUSION: AF is frequently observed in patients with AMI complicated by
heart failure. Current AF, and the development of new AF soon after AMI, is
associated with increased risk of death and stroke.
AD - Division of Cardiology, Helsinki University Central Hospital, Helsinki,
Finland. mika.lehto@fimnet.fi
AN - 15618041
AU - Lehto, M.
AU - Snapinn, S.
AU - Dickstein, K.
AU - Swedberg, K.
DA - Feb
DO - 10.1093/eurheartj/ehi064
DP - NLM
ET - 2004/12/25
IS - 4
KW - Aged
Captopril/therapeutic use
Female
Humans
Losartan/therapeutic use
Male
Middle Aged
Myocardial Infarction/*complications/drug therapy
Prognosis
Stroke/etiology
Ventricular Dysfunction, Left/*complications
LA - eng
N1 - Lehto, Mika
Snapinn, Steven
Dickstein, Kenneth
Swedberg, Karl
Nieminen, Markku S
OPTIMAAL investigators
Clinical Trial
Journal Article
Multicenter Study
England
Eur Heart J. 2005 Feb;26(4):350-6. doi: 10.1093/eurheartj/ehi064. Epub 2004 Dec 9.
PY - 2005
SN - 0195-668X (Print)
0195-668x
SP - 350-6
ST - Prognostic risk of atrial fibrillation in acute myocardial infarction
complicated by left ventricular dysfunction: the OPTIMAAL experience
T2 - Eur Heart J
TI - Prognostic risk of atrial fibrillation in acute myocardial infarction
complicated by left ventricular dysfunction: the OPTIMAAL experience
VL - 26
ID - 2531
ER -
TY - JOUR
AB - Atrioventricular nodal reentrant tachycardia (AVNRT) is probably the most
common form of paroxysmal supraventricular tachycardia. It has two usual types of
surface ECG patterns. In the so-called "common, usual, or typical" form of AVNRT
the retrograde P wave is seen in close proximity to the QRS complex. In the
"uncommon, unusual, or atypical" form of AVNRT the retrograde P wave occurs late,
within or following the T wave. In the common type of AVNRT the reentrant circuit
consists of the slow pathway in the anterograde direction and the fast pathway
retrogradely. In the uncommon type of AVNRT the slow pathway is utilized retrograde
and a relatively fast pathway is utilized in the anterograde direction. Common
symptoms include palpitations, nervousness, anxiety, lightheadedness, neck and
chest discomfort, and dyspnea. AVNRT may cause or worsen heart failure in patients
with poor left ventricular function. It may cause angina or myocardial infarction
in patients with coronary artery disease. Syncope may occur in patients with a
rapid ventricular rate or prolonged tachycardia due to poor ventricular filling,
decreased cardiac output, hypotension, and reduced cerebral circulation.
AN - 20642099
AU - Lelakowski, J.
AU - Rydlewska, A.
AU - Kuniewicz, M.
DA - Jun
DP - NLM
ET - 2010/07/21
IS - 168
J2 - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
KW - *Electrocardiography
Humans
Tachycardia, Atrioventricular Nodal
Reentry/complications/*diagnosis/physiopathology
LA - pol
N1 - Lelakowski, Jacek
Rydlewska, Anna
Kuniewicz, Marcin
Editorial
English Abstract
Poland
Pol Merkur Lekarski. 2010 Jun;28(168):429-37.
OP - Nawrotny czestoskurcz wezłowy przedsionkowo-komorowy--mechanizm arytmil,
obraz kliniczny oraz przykłdy elektrokardiograficznych zapisów.
PY - 2010
SN - 1426-9686 (Print)
1426-9686
SP - 429-37
ST - [Atrioventricular nodal reentrant tachycardia--arrhythmias mechanism,
clinical feature and electrocardiographic recordings]
T2 - Pol Merkur Lekarski
TI - [Atrioventricular nodal reentrant tachycardia--arrhythmias mechanism,
clinical feature and electrocardiographic recordings]
VL - 28
ID - 2807
ER -
TY - JOUR
AB - HISTORY AND ADMISSION FINDINGS: A 69-year-old somnolent woman developed
severe heart failure, aggravated by recurrent episodes of ventricular tachycardia.
The patient showed central and peripheral edema. 24 hours earlier, she had suffered
cerebral seizures that were successfully terminated by phenytoin. For 13 years,
persistent atrial fibrillation had been frequency-controlled with antiarrhythmic
drugs (verapamil and glycosides) and treated by oral anticoagulation. In addition,
there had been long-term anti-depressant therapy with the tetracyclic agent
maprotiline. INVESTIGATIONS: Torsade de pointes tachycardia was documented in the
electrocardiograms. In addition, the QT interval was extensively prolonged (QTc =
0.70 sec). Neither electrolyte disturbances nor acute cardiac ischemia were seen.
Echocardiography revealed a highly reduced ejection fraction of 25 % and a
moderately dilated left ventricle. Angiography showed a collateralized occlusion of
the right and plaques of the left coronary artery. TREATMENT AND COURSE: Repeated
torsade de pointes tachycardia resulted in hemodynamic compromise and were
terminated by defibrillations. After intravenous magnesium and xylocaine
administration as well as with termination of maprotiline and antiarrhythmic co-
medication, QT prolongation decreased. In addition, the recurrent torsade de
pointes tachycardia stopped. Subsequently, however, there were several bradycardia
episodes, QT duration remained long. Accordingly, a VVI pacemaker was implanted. Up
to now, the patient is doing well. CONCLUSIONS: With antidepressant therapy, a
risky constellation including comorbidity and interactions with potentially
arrhythmogenic drugs may lead to QT prolongation. Medication that delays conduction
or causes bradycardia may generally favour torsade de pointes tachycardia. In case
of indispensable multi-drug therapy, regular clinical as well as
electrocardiographic monitoring with special emphasis on QT interval is mandatory.
AD - Medizinische Klinik und Poliklinik II, Universitätsklinikum Bonn.
AN - 11740632
AU - Lentini, S.
AU - Rao, M. L.
AU - Schröder, R.
AU - Lüderitz, B.
AU - Bauriedel, G.
DA - Dec 7
DO - 10.1055/s-2001-18880
DP - NLM
ET - 2001/12/12
IS - 49
KW - Aged
Anti-Arrhythmia Agents/administration & dosage/adverse effects/therapeutic use
Antidepressive Agents, Second-Generation/*adverse effects
Drug Interactions
Echocardiography
Electrocardiography
Female
Humans
Lidocaine/administration & dosage/therapeutic use
Long QT Syndrome/*chemically induced/diagnosis/therapy
Magnesium/administration & dosage/therapeutic use
Maprotiline/*adverse effects
Recurrence
Risk Factors
Tachycardia, Ventricular/chemically induced/diagnosis/therapy
Torsades de Pointes/*chemically induced/diagnosis/therapy
LA - ger
N1 - Lentini, S
Rao, M L
Schröder, R
Lüderitz, B
Bauriedel, G
Case Reports
English Abstract
Journal Article
Germany
OP - QT-Verlängerung und Torsade de pointes-Tachykardie bei Therapie mit
Maprotilin. Differenzialdiagnostische und -therapeutische Aspekte.
PY - 2001
SN - 0012-0472 (Print)
0012-0472
SP - 1396-400
ST - [QT prolongation and torsade de pointes tachycardia during therapy with
maprotiline. Differential diagnostic and therapeutic aspects]
TI - [QT prolongation and torsade de pointes tachycardia during therapy with
maprotiline. Differential diagnostic and therapeutic aspects]
VL - 126
ID - 2854
ER -
TY - JOUR
AB - BACKGROUND: Atrial fibrillation (AF) is an identified risk factor for
ischemic strokes (IS). AF causes a loss in atrial contractile function that favors
the formation of thrombi, and thus increases the risk of stroke. Also, AF produces
highly irregular and complex temporal dynamics in ventricular response RR
intervals. Thus, it is hypothesized that the analysis of RR dynamics could provide
predictors for IS. However, these complex and nonlinear dynamics call for the use
of advanced multiscale nonlinear signal processing tools. OBJECTIVES: The global
aim is to investigate the performance of a recently-proposed multiscale and
nonlinear signal processing tool, the scattering transform, in predicting IS for
patients suffering from AF. METHODS: The heart rate of a cohort of 173 patients
from Fujita Health University Hospital in Japan was analyzed with the scattering
transform. First, p-values of Wilcoxon rank sum tests were used to identify
scattering coefficients achieving significant (univariate) discrimination between
patients with and without IS. Second, a multivariate procedure for feature
selection and classification, the Sparse Support Vector Machine (S-SVM), was
applied to predict IS. RESULTS: Groups of scattering coefficients, located at
several time-scales, were identified as significantly higher (p-value < 0.05) in
patients who developed IS than in those who did not. Though the overall predictive
power of these indices remained moderate (around 60 %), it was found to be much
higher when analysis was restricted to patients not taking antithrombotic treatment
(around 80 %). Further, S-SVM showed that multivariate classification improves IS
prediction, and also indicated that coefficients involved in classification differ
for patients with and without antithrombotic treatment. CONCLUSIONS: Scattering
coefficients were found to play a significant role in predicting IS, notably for
patients not receiving antithrombotic treatment. S-SVM improves IS detection
performance and also provides insight on which features are important. Notably, it
shows that AF patients not taking antithrombotic treatment are characterized by a
slow modulation of RR dynamics in the ULF range and a faster modulation in the HF
range. These modulations are significantly decreased in patients with IS, and hence
have a good discriminant ability.
AN - 29719922
AU - Leonarduzzi, R.
AU - Abry, P.
AU - Wendt, H.
AU - Kiyono, K.
AU - Yamamoto, Y.
AU - Watanabe, E.
AU - Hayano, J.
DA - May
DO - 10.3414/me17-02-0006
DP - NLM
ET - 2018/05/03
IS - 3
J2 - Methods of information in medicine
KW - Area Under Curve
Atrial Fibrillation/*complications/*physiopathology
Heart Rate/*physiology
Humans
Machine Learning
Stroke/*complications/*physiopathology
Support Vector Machine
LA - eng
N1 - 2511-705x
Leonarduzzi, Roberto
Abry, Patrice
Wendt, Herwig
Kiyono, Ken
Yamamoto, Yoshiharu
Watanabe, Eiichi
Hayano, Junichiro
Journal Article
Germany
Methods Inf Med. 2018 May;57(3):141-145. doi: 10.3414/ME17-02-0006. Epub 2018 May
2.
PY - 2018
SN - 0026-1270
SP - 141-145
ST - Scattering Transform of Heart Rate Variability for the Prediction of Ischemic
Stroke in Patients with Atrial Fibrillation
T2 - Methods Inf Med
TI - Scattering Transform of Heart Rate Variability for the Prediction of Ischemic
Stroke in Patients with Atrial Fibrillation
VL - 57
ID - 2348
ER -
TY - JOUR
AB - One hundred and sixty-eight out of 296 patients who died of acute myocardial
infarction (AMI) in the Coronary Care Unit were studied to assess the cause of
death. Twenty-two of them had received thrombolytic therapy. The mean age of these
patients was 64.3 +/- 18.2 years. One hundred and eight subjects were male and 60
were female. One hundred and nine cases (64.8%) showed, at postmortem examination,
histopathologic alterations due to acute myocardial infarction (AMI). Death was due
to heart failure in 35.8%, cardiogenic shock in 20% and ventricular arrhythmia in
44%. The other 59 patients died from complications superimposed upon AMI:
reinfarction (23.7%), heart rupture (40.7%), myocardial fibrosis and reinfarction
(18.6%), and cerebral infarction (17%). Two of these patients also showed massive
pneumonia. In those subjects who had received thrombolytic therapy, a broad
spectrum of arrhythmic and haemorrhagic complications were seen (68%). Four causes
of death were seen in the subjects studied: AMI, superimposed cardiac
complications, side-effects of thrombolytic treatment, and non-cardiac causes.
Patients who did not receive thrombolysis mechanical events eg heart failure,
characterized their deaths. In subjects who had received thrombolytic therapy,
arrhythmic and haemorrhagic were widely observed.
AD - City Hospital, Division di Medicine, Ospedale di Pontremoli, Pontremoli (MS),
Italy.
AN - 8942226
AU - Leone, A.
DA - Jun
DP - NLM
ET - 1996/06/01
IS - 3
J2 - Singapore medical journal
KW - Adult
Age Distribution
Aged
Aged, 80 and over
Autopsy
Female
*Hospital Mortality
Humans
Male
Middle Aged
*Myocardial Infarction/drug therapy/mortality/pathology
Sex Distribution
Singapore
Survival Rate
LA - eng
N1 - Leone, A
Comparative Study
Journal Article
Singapore
Singapore Med J. 1996 Jun;37(3):270-2.
PY - 1996
SN - 0037-5675 (Print)
0037-5675
SP - 270-2
ST - Causes of death from myocardial infarction before and after thrombolysis era:
a pathologic study
T2 - Singapore Med J
TI - Causes of death from myocardial infarction before and after thrombolysis era:
a pathologic study
VL - 37
ID - 3103
ER -
TY - JOUR
AB - BACKGROUND: Dipyridamole imaging is widely used as an alternative to exercise
testing to identify and risk stratify patients with coronary artery disease. Safety
data on intravenous dipyridamole stress testing has been derived largely from
individual institutional data. METHODS AND RESULTS: Data were collected
retrospectively by 85 coinvestigators from 73,806 patients who underwent
intravenous dipyridamole stress imaging in 59 hospitals and 19 countries to
determine the incidence of major adverse reactions during testing. The dose of
dipyridamole infused was 0.56 mg/kg in 64,740 patients, 0.74 mg/kg in 6551
patients, and 0.84 mg/kg in 2515 patients. Combined major adverse events among the
entire 73,806 patients included seven cardiac deaths (0.95 per 10,000), 13 nonfatal
myocardial infarctions (1.76 per 10,000), six nonfatal sustained ventricular
arrhythmias (0.81 per 10,000) (ventricular tachycardia in two and ventricular
fibrillation in four), nine transient cerebral ischemic attacks (1.22 per 10,000),
(with speech or motor deficit), one stroke, and nine severe bronchospasms (1.22 per
10,000) (one intubation and eight near intubations). In addition to the safety
data, detailed demographic, peripheral hemodynamic, side effect, and concomitant
drug data were examined in a subgroup of 3751 patients. End points from subsets of
patients were compared with those of the group as a whole. Multivariate analysis
revealed that dipyridamole-induced chest pain was more common in patients less than
70 years old (p = 0.0017), those with a history of coronary revascularization (p =
0.002), or patients taking aspirin (p = 0.0001). Minor noncardiac side effects were
less frequent among the elderly (p = 0.0053) and more frequent in women (p =
0.0001) and patients taking maintenance aspirin (p = 0.0034). When a patient was
judged on the basis of the adequacy of hemodynamic response to be a dipyridamole
"nonresponder" (< 10 mm Hg drop in systolic blood pressure and 10 beats/min
increase in heart rate), the only significant predictor was angiotensin-converting
enzyme inhibitor intake (p = 0.0025). Inferoposterior hypoperfusion was
significantly more frequent in patients with dipyridamole-induced hypotension: 57%
(44/77) (p < 0.0001) of those who had hypotension and 89% (8/9) (p = 0.0076) who
had severe symptomatic bradyarrhythmias displayed inferoposterior defects on
thallium scanning. Caffeine levels were determined in 391 consecutive patients:
levels greater than 5 mg/L were observed in only eight patients (2%), suggesting
that methylxanthine levels sufficient to alter the hemodynamic response to
dipyridamole resulting in suboptimal hyperemic stress are unlikely when patients
take nothing by mouth after midnight. CONCLUSION: The risk of serious dipyridamole-
induced side effects is very low and is comparable to that reported for exercise
testing in a similar patient population.
AD - Maisonneuve Hospital, Montreal, Quebec, Canada.
AN - 9420757
AU - Lette, J.
AU - Tatum, J. L.
AU - Fraser, S.
AU - Miller, D. D.
AU - Waters, D. D.
AU - Heller, G.
AU - Stanton, E. B.
AU - Bom, H. S.
AU - Leppo, J.
AU - Nattel, S.
DA - Jan-Feb
DO - 10.1016/s1071-3581(05)80003-0
DP - NLM
ET - 1995/01/01
IS - 1
J2 - Journal of nuclear cardiology : official publication of the American Society
of Nuclear Cardiology
KW - Adult
Age Factors
Aged
Coronary Disease/*diagnostic imaging
Dipyridamole/*adverse effects
Female
Heart/*diagnostic imaging
Humans
Male
Middle Aged
Myocardial Infarction/chemically induced
Radionuclide Imaging
Regression Analysis
LA - eng
N1 - Lette, J
Tatum, J L
Fraser, S
Miller, D D
Waters, D D
Heller, G
Stanton, E B
Bom, H S
Leppo, J
Nattel, S
Journal Article
Multicenter Study
United States
J Nucl Cardiol. 1995 Jan-Feb;2(1):3-17. doi: 10.1016/s1071-3581(05)80003-0.
PY - 1995
SN - 1071-3581 (Print)
1071-3581
SP - 3-17
ST - Safety of dipyridamole testing in 73,806 patients: the Multicenter
Dipyridamole Safety Study
T2 - J Nucl Cardiol
TI - Safety of dipyridamole testing in 73,806 patients: the Multicenter
Dipyridamole Safety Study
VL - 2
ID - 2901
ER -
TY - JOUR
AB - AIMS: Atrial fibrillation (AF) is an independent risk factor for ischaemic
stroke. The CHA2DS2-VASc is the most widely used risk stratification model;
however, echocardiographic refinement may be useful, particularly in low risk AF
patients. The present study examined the association between advanced
echocardiographic parameters and ischaemic stroke, independent of CHA2DS2-VASc
score. METHODS AND RESULTS: One thousand, three hundred and sixty-one patients
(mean age 65±12 years, 74% males) with first diagnosis of AF and baseline
transthoracic echocardiogram were followed by chart review for the occurrence of
stroke over a mean of 7.9 years. Left atrial (LA) volumes, LA reservoir strain, P-
wave to A' duration on tissue Doppler imaging (PA-TDI, reflecting total atrial
conduction time), and left ventricular (LV) global longitudinal strain (GLS) were
evaluated in patients with and without stroke. The independent association of these
echocardiographic parameters with the occurrence of ischaemic stroke was evaluated
with Cox proportional hazard models. One-hundred patients (7%) developed an
ischaemic stroke, representing an annualized stroke rate of 0.9%. The incident
stroke rate in the year following the first diagnosis of AF was 2.6% in the entire
population and higher than the remainder of the follow-up period. Left atrial
reservoir (14.5% vs. 18.9%, P = 0.005) and conduit strains were reduced (10.5% vs.
13.5%, P = 0.013), and PA-TDI lengthened (166 ms vs. 141 ms, P < 0.001) in the
stroke compared with non-stroke group, despite similar LV dimensions, LV ejection
fraction, GLS, and LA volumes. Left atrial reservoir strain and PA-TDI were
independently associated with risk of stroke in a model including CHA2DS2-VASc
score, age, and anticoagulant use. CONCLUSION: The assessment of LA reservoir
strain and PA-TDI on echocardiography after initial CHA2DS2-VASc scoring provides
additional risk stratification for stroke and may be useful to guide decisions
regarding anticoagulation for patients upon first diagnosis of AF.
AD - Department of Cardiology, Leiden University Medical Centre, Albinusdreef 2,
Leiden 2300RC, The Netherlands.
Department of Cardiology, Ingham Institute at Liverpool Hospital, University of New
South Wales, Corner of Elizabeth and Goulburn Streets, Liverpool NSW 2170, Sydney,
Australia.
AN - 29300883
AU - Leung, M.
AU - van Rosendael, P. J.
AU - Abou, R.
AU - Ajmone Marsan, N.
AU - Leung, D. Y.
AU - Delgado, V.
AU - Bax, J. J.
DA - Apr 21
DO - 10.1093/eurheartj/ehx736
DP - NLM
ET - 2018/01/05
IS - 16
KW - Aged
Atrial Fibrillation/*complications/diagnostic imaging/physiopathology
*Atrial Function, Left/physiology
Echocardiography
Electrocardiography
Female
Humans
Male
Registries
Risk Factors
Stroke/*etiology
LA - eng
N1 - 1522-9645
Leung, Melissa
van Rosendael, Philippe J
Abou, Rachid
Ajmone Marsan, Nina
Leung, Dominic Y
Delgado, Victoria
Bax, Jeroen J
Journal Article
England
Eur Heart J. 2018 Apr 21;39(16):1416-1425. doi: 10.1093/eurheartj/ehx736.
PY - 2018
SN - 0195-668x
SP - 1416-1425
ST - Left atrial function to identify patients with atrial fibrillation at high
risk of stroke: new insights from a large registry
T2 - Eur Heart J
TI - Left atrial function to identify patients with atrial fibrillation at high
risk of stroke: new insights from a large registry
VL - 39
ID - 2329
ER -
TY - JOUR
AB - The low osmolar nonionic contrast medium Omnipaque was used in 5,339
consecutive coronary angiographies and serious complications were registered.
Myocardial infarction occurred in 4 patients, of whom 2 died, and ventricular
fibrillation in 1. Cerebral embolism occurred in 11 patients, all of whom survived.
The results are compared with those of previous series of coronary angiography with
high osmolar ionic media. It is concluded that use of the nonionic medium Omnipaque
resulted in a significant reduction of the frequency of serious complications.
AD - Department of Diagnostic Radiology, National Hospital, University of Oslo,
Norway.
AN - 2500247
AU - Levorstad, K.
AU - Vatne, K.
AU - Brodahl, U.
AU - Laake, B.
AU - Simonsen, S.
AU - Aakhus, T.
DA - Mar-Apr
DO - 10.1007/bf02577398
DP - NLM
ET - 1989/03/01
IS - 2
J2 - Cardiovascular and interventional radiology
KW - Adult
Aged
*Contrast Media/administration & dosage/adverse effects
Coronary Disease/diagnostic imaging
Humans
*Iohexol/administration & dosage/adverse effects
Male
Middle Aged
Prospective Studies
Safety
LA - eng
N1 - Levorstad, K
Vatne, K
Brodahl, U
Laake, B
Simonsen, S
Aakhus, T
Journal Article
United States
Cardiovasc Intervent Radiol. 1989 Mar-Apr;12(2):98-100. doi: 10.1007/BF02577398.
PY - 1989
SN - 0174-1551 (Print)
0174-1551
SP - 98-100
ST - Safety of the nonionic contrast medium omnipaque in coronary angiography
T2 - Cardiovasc Intervent Radiol
TI - Safety of the nonionic contrast medium omnipaque in coronary angiography
VL - 12
ID - 3030
ER -
TY - JOUR
AB - Atrial fibrillation (AF), carries a serious risk of systemic embolic
complications, especially cerebral. Antiarrhythmic therapy is the most used method
for restoring or maintaining sinus rhythm, and for preventing recurrences or of
controlling the ventricular response. A clinical classification was recently
suggested to define when to use antiarrhythmic drugs. In a first episode of
symptomatic AF (Class I), it is not possible to assess the chances of recurrence
and preventive antiarrhythmic therapy would not seem justified. In recurrent
paroxysmal AF, the arrhythmias may be asymptomatic (Class IIa) and antiarrhythmic
therapy may be questionned. When the attacks are infrequent (< 1 every 3 months,
Class IIb), episodic pharmacological intervention to restore sinus rhythm or to
slow the ventricular rate may be valuable, but the efficacy and safety of such
treatment should be assessed. In Class IIc, appropriate antiarrhythmic treatment to
prevent recurrence is often indicated. Atrial fibrillation resistant to one or more
antiarrhythmic drugs (Class III) may also be subdivised into three subgroups as for
Class II. In addition to the use of alternating of antiarrhythmic drugs not
previously used, it is justifiable to consider investigations to determine the
mechanism of resistant AF use only drugs of the which slow the ventricular rate.
The choice of antiarrhythmic drug may be guided by the concepts of the Silician
Gambit, taking into consideration the mechanism of AF and the therapeutic
objective. In AF, the mechanism is reentry, the vulnerable parameter the atrial
refractory period. To increase the refractory period, the target should be the
sodium or potassium currents. The status of left ventricular function is an
important parameter in the choice of an antiarrhythmic agent.
AD - Service de cardiologie, hôpital Nord, Marseille.
AN - 8734159
AU - Lévy, S.
AU - Ricard, P.
AU - Yapo, F.
AU - Mansouri, C.
DA - Feb
DP - NLM
ET - 1996/02/01
KW - Anti-Arrhythmia Agents/pharmacology/*therapeutic use
Atrial Fibrillation/classification/*drug therapy/physiopathology/prevention &
control
Heart Conduction System/drug effects
Humans
Recurrence
LA - fre
N1 - Lévy, S
Ricard, P
Yapo, F
Mansouri, C
English Abstract
Journal Article
Meta-Analysis
France
Arch Mal Coeur Vaiss. 1996 Feb;89 Spec No 1:19-24.
OP - Les médicaments antiarythmiques dans la fibrillation auriculaire
paroxystique. Quand et comment?
PY - 1996
SN - 0003-9683 (Print)
0003-9683
SP - 19-24
ST - [Antiarrhythmic drugs in paroxysmal atrial fibrillation. When and how?]
TI - [Antiarrhythmic drugs in paroxysmal atrial fibrillation. When and how?]
VL - 89 Spec No 1
ID - 2801
ER -
TY - JOUR
AB - BACKGROUND: The application of phase-modulated near-infrared techniques for
measurement of the oxygen saturation of cerebral tissue requires both validation by
conventional measures of cerebral oxygenation and determination of normal and
abnormal values. This study was undertaken to validate phase-modulated near-
infrared measurements of cerebral oxygen saturation by comparing them with
electroencephalographic evidence of cerebral ischemia during implantation of
cardioverting defibrillators. This comparison also yields an estimate of the
ischemic threshold as measured with near-infrared techniques. METHODS:
Electroencephalograms and near-infrared measurements were performed during 85
episodes of ventricular fibrillation in ten patients. Light at 754, 785, and 816 nm
was modulated at 200 MHz, transmitted through the skull, and the path lengths of
the reflected light were determined by measuring the phase shifts. The
electroencephalogram was inspected for changes during the hypotension associated
with the arrhythmia and the oxygen saturation was calculated from the near-infrared
path lengths. Changes in oxygen saturation were then compared with
electroencephalographic evidence of cerebral ischemia. RESULTS: The mean saturation
before fibrillation was 56.5% +/- 1.2 (SEM). In 40 (47%) of the events,
electroencephalographic evidence of ischemia was observed. Such changes were
related to the minimum saturation observed during ventricular fibrillation (44% +/-
2.5 vs. 56% +/- 1.9 in the absence of electroencephalographic changes; P < 0.001).
The ischemic threshold was estimated to be 47% saturation. The sensitivity of this
technique was estimated to be 0.6, the specificity 0.84, and the predictive
accuracy 0.73. CONCLUSIONS: Near-infrared measurements reflect changes in cerebral
oxygenation as indicated by electroencephalographic evidence of cerebral ischemia.
AD - Department of Anesthesia, University of Pennsylvania School of Medicine,
Philadelphia 19104-4283, USA.
AN - 7574053
AU - Levy, W. J.
AU - Levin, S.
AU - Chance, B.
DA - Oct
DO - 10.1097/00000542-199510000-00013
DP - NLM
ET - 1995/10/01
IS - 4
J2 - Anesthesiology
KW - Aged
Brain/*metabolism
Brain Ischemia/*metabolism
Humans
Male
Oximetry
Oxygen/*metabolism
Ventricular Fibrillation/*metabolism
LA - eng
N1 - Levy, W J
Levin, S
Chance, B
Journal Article
United States
Anesthesiology. 1995 Oct;83(4):738-46. doi: 10.1097/00000542-199510000-00013.
PY - 1995
SN - 0003-3022 (Print)
0003-3022
SP - 738-46
ST - Near-infrared measurement of cerebral oxygenation. Correlation with
electroencephalographic ischemia during ventricular fibrillation
T2 - Anesthesiology
TI - Near-infrared measurement of cerebral oxygenation. Correlation with
electroencephalographic ischemia during ventricular fibrillation
VL - 83
ID - 2852
ER -
TY - JOUR
AB - BACKGROUND: Ventricular diverticulum (VD) is a rare cardiac malformation. The
surgical indications for VD remain controversial. This review is designed to
determine the demographic characteristics, diagnosis, and surgical indications of
this disease. METHODS: Using PubMed and the Chinese electronic databases CNKI,
WANFANG, and VIP, a computerized search was performed of the literature from China
published between March 1965 and July 2012. Major risk factors for developing VD
complications were confirmed by logistic regression analysis in case-control
studies. RESULTS: Ninety-three articles and 127 VD patients were identified in this
literature review. VDs can lead to aortic insufficiency, thrombosis, infective
endocarditis, heart failure, diverticular rupture, ventricular arrhythmia, and
cerebral embolism. In patients with VD complications, 92.3% were men (OR = 6.43,
95% CI = 1.23-33.53), 84.6% of the patients had a fibrous type VD (OR = 10.54, 95%
CI = 2.86-38.85), and 48.0% of the cases were subaortic diverticulum (SD) related
(OR = 6.41, 95% CI = 1.17-35.19). CONCLUSIONS: VD can result in rupture, cerebral
embolism, heart failure, ventricular arrhythmia, infective endocarditis, thrombosis
and aortic insufficiency. Male gender, fibrous type, and SD are three major
independent risk factors for developing VD complications. Surgical resection should
be performed in those VD patients with risk factors for major complications.
AD - Department of Cardiovascular Surgery, Shandong Provincial Qianfoshan
Hospital, Shandong University, Jinan, China. liquann@hotmail.com
AN - 23311636
AU - Li, Q.
AU - Qu, H.
AU - Wang, H.
AU - Wang, D.
AU - Li, P.
AU - Liu, T.
DA - Mar
DO - 10.1111/jocs.12059
DP - NLM
ET - 2013/01/15
IS - 2
J2 - Journal of cardiac surgery
KW - China/epidemiology
*Diverticulum/complications/diagnosis/epidemiology/surgery
*Heart Diseases/complications/diagnosis/epidemiology/surgery
Humans
Incidence
Logistic Models
Risk Factors
Treatment Outcome
LA - eng
N1 - 1540-8191
Li, Quan
Qu, Hong
Wang, Haiyan
Wang, Dong
Li, Peijie
Liu, Tianqi
Journal Article
Review
United States
J Card Surg. 2013 Mar;28(2):133-8. doi: 10.1111/jocs.12059. Epub 2013 Jan 13.
PY - 2013
SN - 0886-0440
SP - 133-8
ST - Ventricular diverticulum: a review of the literature
T2 - J Card Surg
TI - Ventricular diverticulum: a review of the literature
VL - 28
ID - 3059
ER -
TY - JOUR
AB - BACKGROUND: Catheter ablation for atrial fibrillation (AF) has been
demonstrated to be effective in a subsets of patients with AF. However, very few
data are available in regard to patients with prior history of stroke undergoing
catheter ablation. This study aimed to investigate the outcome of catheter ablation
in AF patients with prior ischemic stroke. METHODS: Between January 2008 and
December 2011, of 1897 consecutive patients who presented at Beijing An Zhen
Hospital for treatment of drug-refractory AF, 172 (9.1%) patients in the study
population had a history of ischemic stroke. All patients underwent catheter
ablation and were followed up to assess maintenance of sinus rhythm and recurrence
of symptomatic stroke. RESULTS: Among these 1897 patients, 1768 (93.2%) who had
complete follow-up information for a minimum of six months were included in the
final analysis. Patients in the stroke group (group I) and the no-stroke group
(group II) were similar in regards to gender, body mass index (BMI), history of
diabetes, type of AF, and left atrial size. The patients in group I were older than
those in group II, and had a higher incidence of hypertension, chronic heart
failure, lower left ventricular ejection fraction (LVEF), and higher CHADS2 scores.
Six months after ablation, 107 (68.6%) patients in group I and 1403 (87.1%) in
group II had discontinued warfarin treatment (P < 0.001). During a median follow-up
of (633 ± 415) days, 65 patients in the group I and 638 in group II experienced AF
recurrence, and five patients in group I and 28 in group II developed symptomatic
stroke. The rates of AF recurrence and recurrent stroke were similar between group
I and group II (41.7% vs. 39.6%, P = 0.611; 3.2% vs. 1.7%, P = 0.219;
respectively). CONCLUSION: Catheter ablation of AF in patients with prior stroke is
feasible and efficient.
AD - Department of Cardiology, Beijing An Zhen Hospital, Capital Medical
AN - 23506574
AU - Li, S. N.
AU - Kang, J. P.
AU - Du, X.
AU - He, X. N.
AU - Long, D. Y.
AU - Yu, R. H.
AU - Tang, R. B.
AU - Sang, C. H.
AU - Jiang, C. X.
AU - Ning, M.
AU - Dong, J. Z.
AU - Ma, C. S.
DA - Mar
DP - NLM
ET - 2013/03/20
IS - 6
J2 - Chinese medical journal
KW - Aged
Female
Humans
Male
Middle Aged
Stroke/*surgery
LA - eng
N1 - 2542-5641
Li, Song-Nan
Kang, Jun-Ping
DU, Xin
He, Xiao-Nan
Long, De-Yong
Yu, Rong-Hui
Tang, Ri-Bo
Sang, Cai-Hua
Jiang, Chen-Xi
Ning, Man
Dong, Jian-Zeng
Ma, Chang-Sheng
Journal Article
China
Chin Med J (Engl). 2013 Mar;126(6):1033-8.
PY - 2013
SN - 0366-6999
SP - 1033-8
ST - Outcome of catheter ablation of atrial fibrillation in patients with prior
ischemic stroke
T2 - Chin Med J (Engl)
TI - Outcome of catheter ablation of atrial fibrillation in patients with prior
ischemic stroke
VL - 126
ID - 2606
ER -
TY - JOUR
AB - BACKGROUND: Left ventricular hypertrophy (LVH) is an independent predictor of
new-onset atrial fibrillation. Whether LVH can predict the recurrence of arrhythmia
after radiofrequency catheter ablation (RFCA) in patients with paroxysmal atrial
fibrillation (PAF) remains unclear. HYPOTHESIS: PAF patients with baseline-
electrocardiographic LVH has a higher recurrence rate after RFCA procedure compared
with those without LVH. METHODS: A total of 436 patients with PAF undergoing first
RFCA were consecutively enrolled and clustered into 2 groups based on
electrocardiogram (ECG) findings: non-ECG LVH (218 patients) and ECG LVH (218
patients). LVH was characterized by the Romhilt-Estes point score system; the
score ≥5points were defined as LVH. RESULTS: At 42 months' (interquartile range,
18.0-60.0 months) follow-up after RFCA, 151 (69.3%) patients in the non-ECG LVH
group and 108 (49.5%) patients in the ECG LVH group maintained sinus rhythm without
using antiarrhythmic drugs (P < 0.001). Patients with ECG LVH tended to experience
a much higher prevalence of stroke and recurrence of atrial arrhythmia episodes
compared with those without ECG LVH (log-rank P < 0.001). Multivariate analysis
found the presence of ECG LVH and left atrial diameter to be independent risk
factors for recurrence after adjusting for confounding factors. CONCLUSIONS: The
presence of ECG LVH was a strong and independent predictor of recurrence in
patients with PAF following RFCA.
AD - Department of Cardiology, Beijing Anzhen Hospital, Capital Medical
University, National Clinical Research Centre for Cardiovascular Diseases, Beijing,
China.
AN - 29604089
AU - Li, S. N.
AU - Wang, L.
AU - Dong, J. Z.
AU - Yu, R. H.
AU - Long, D. Y.
AU - Tang, R. B.
AU - Sang, C. H.
AU - Jiang, C. X.
AU - Liu, N.
AU - Bai, R.
AU - Du, X.
AU - Ma, C. S.
C2 - PMC6490114
DA - Jun
DO - 10.1002/clc.22957
DP - NLM
ET - 2018/04/01
IS - 6
KW - Aged
Atrial Fibrillation/diagnosis/epidemiology/physiopathology/*surgery
China/epidemiology
Female
Humans
Hypertrophy, Left Ventricular/*diagnosis/epidemiology/physiopathology
Male
Middle Aged
Prevalence
Recurrence
Risk Factors
Stroke/epidemiology
Time Factors
Treatment Outcome
*Ventricular Remodeling
Atrial Fibrillation
Electrocardiogram
Left Ventricular Hypertrophy
Radiofrequency Catheter Ablation
LA - eng
N1 - 1932-8737
Li, Song-Nan
Wang, Lu
Dong, Jian-Zeng
Orcid: 0000-0001-7299-7805
Yu, Rong-Hui
Long, De-Yong
Tang, Ri-Bo
Sang, Cai-Hua
Jiang, Chen-Xi
Liu, Nian
Bai, Rong
Du, Xin
Ma, Chang-Sheng
Journal Article
Clin Cardiol. 2018 Jun;41(6):797-802. doi: 10.1002/clc.22957. Epub 2018 Jun 5.
PY - 2018
SN - 0160-9289 (Print)
0160-9289
SP - 797-802
ST - Electrocardiographic left ventricular hypertrophy predicts recurrence of
atrial arrhythmias after catheter ablation of paroxysmal atrial fibrillation
T2 - Clin Cardiol
TI - Electrocardiographic left ventricular hypertrophy predicts recurrence of
atrial arrhythmias after catheter ablation of paroxysmal atrial fibrillation
VL - 41
ID - 2403
ER -
TY - JOUR
AB - BACKGROUND: Heart failure (HF) is a risk factor for atrial fibrillation (AF),
stroke, and post-stroke disability. However, differing definitions and application
of HF-criteria may impact model prediction. We compared the predictive ability of
left ventricular ejection fraction (LVEF), a readily available objective
echocardiographic index, with clinical HF definitions for functional disability and
AF in stroke patients. METHODS: We retrospectively analyzed ischemic stroke
patients evaluated between January 2013 and May 2015. Outcomes of interest were:
(a) 90-day functional disability (modified Rankin score 3-6) and (b) AF. We
compared: (1) LVEF (continuous variable), (2) left ventricular systolic dysfunction
(LVSD)-categories (absent to severe), (3) clinical history of HF, and (4) HF/LVSD-
categories: (i) HF absent without LVSD, (ii) HF absent with LVSD, (iii) HF with
preserved ejection fraction (HFpEF), and (iv) HF with reduced ejection fraction
(HFrEF). Multivariable logistic regression was used to determine the predictive
ability for 90-day disability and AF, respectively. RESULTS: Six hundred eighty
five consecutive patients (44.5% female) fulfilled the study criteria and were
included. After adjustment, the LVEF was independently associated with 90-day
disability (OR .98, 95% CI .96-.99, P = .011) with similar predictive ability (area
under the curve [AUC] = .85) to models including the LVSD-categories (AUC = .85),
clinically define HF (AUC = .86), and HF/LVSD-categories (AUC = .86). The LVEF, HF,
LVSD-, and HF/LVSD-categories were independently associated with AF (P < .01, each)
with similar predictive ability (AUC = .74, .74, .73, and .75, respectively).
CONCLUSIONS: Compared to commonly defined HF definitions, the objectively
determined LVEF possesses comparable predictive ability for 90-day disability and
AF in stroke patients.
AD - Department of Neurology, University of Massachusetts Medical School,
Worcester, Massachusetts. Electronic address: lyi@stanford.edu.
Department of Medicine, Division of Cardiovascular Medicine, University of
Massachusetts Medical School, Worcester, Massachusetts. Electronic address:
Timothy.Fitzgibbons@umassmed.edu.
Department of Medicine, Division of Cardiovascular Medicine, University of
Massachusetts Medical School, Worcester, Massachusetts. Electronic address:
David.McManus@umassmed.edu.
Department of Neurology, University of Massachusetts Medical School, Worcester,
Massachusetts. Electronic address: Richard.Goddeau@umassmemorial.org.
Massachusetts. Electronic address: Brian.Silver@umassmemorial.org.
Massachusetts; Department of Psychiatry, University of Massachusetts Medical
School, Worcester, Massachusetts. Electronic address: nils.henninger@umassmed.edu.
AN - 30396839
AU - Li, Y.
AU - Fitzgibbons, T. P.
AU - McManus, D. D.
AU - Goddeau, R. P., Jr.
AU - Silver, B.
AU - Henninger, N.
C2 - PMC6320316
C6 - NIHMS1509369
DA - Feb
DP - NLM
ET - 2018/11/07
IS - 2
KW - Aged
Aged, 80 and over
Echocardiography
Female
Heart Failure/classification/*complications/diagnostic imaging/physiopathology
Humans
Male
Middle Aged
Prognosis
Risk Assessment
Risk Factors
*Stroke Volume
Time Factors
Ventricular Dysfunction, Left/classification/*complications/diagnostic
imaging/physiopathology
Atrial fibrillation
HFpEF
HFrEF
Toast
cardioembolism
disability
heart failure
outcome
LA - eng
N1 - 1532-8511
Li, Yi
Fitzgibbons, Timothy P
McManus, David D
Goddeau, Richard P Jr
Silver, Brian
Henninger, Nils
K08 NS091499/NS/NINDS NIH HHS/United States
Comparative Study
Journal Article
J Stroke Cerebrovasc Dis. 2019 Feb;28(2):371-380. doi:
10.1016/j.jstrokecerebrovasdis.2018.10.002. Epub 2018 Nov 2.
PY - 2019
SN - 1052-3057 (Print)
1052-3057
SP - 371-380
ST - Left Ventricular Ejection Fraction and Clinically Defined Heart Failure to
Predict 90-Day Functional Outcome After Ischemic Stroke
TI - Left Ventricular Ejection Fraction and Clinically Defined Heart Failure to
Predict 90-Day Functional Outcome After Ischemic Stroke
VL - 28
ID - 2310
ER -
TY - JOUR
AB - Wellens' syndrome represents critical occlusion of the proximal left anterior
descending coronary artery. Electrocardiographic changes similar to Wellens' wave
are not exceptional to acute coronary occlusion and can also be seen in cardiac and
non-cardiac conditions, such as left ventricular hypertrophy, persistent juvenile T
wave, bundle branch blocks, cerebral haemorrhage, pulmonary oedema, pulmonary
embolism, pheochromocytoma, Takotsubo syndrome, digitalis and cocaine-induced
coronary vasospasm. Cocaine-induced pseudo-Wellens' syndrome should be considered
as one of the differentials, since cocaine is used frequently by young adults and
can cause left anterior descending coronary vasospasm mimicking Wellens' syndrome.
Initiation of the beta-blocking agent in pseudo-Wellens' syndrome as a part of
acute coronary syndrome management can be disastrous. We illustrated a case of
cocaine-induced pseudo-Wellens' syndrome presented with typical chest pain
associated with Wellenoid ECG.
AD - Department of Internal Medicine, The Brooklyn Hospital Center, Brooklyn, New
York, USA.
Department of Cardiology, The Brooklyn Hospital Center, Brooklyn, New York, USA.
Department of Cardiology, The Brooklyn Hospital Center-Mount Sinai- Beth Israel
Hospital, New York, New York, USA.
AN - 29246935
AU - Lin, A. N.
AU - Lin, S.
AU - Gokhroo, R.
AU - Misra, D.
C2 - PMC5753703
DA - Dec 14
DO - 10.1136/bcr-2017-222835
DP - NLM
ET - 2017/12/17
J2 - BMJ case reports
KW - Adrenergic beta-Antagonists/administration & dosage/therapeutic use
Bundle-Branch Block/chemically induced/*diagnosis/diagnostic imaging/drug therapy
Chest Pain/etiology
Cocaine/*adverse effects
Electrocardiography
Humans
Male
Middle Aged
Syndrome
arrhythmias
cardiovascular medicine
cardiovascular system
LA - eng
N1 - 1757-790x
Lin, Aung Naing
Lin, Sithu
Gokhroo, Rahul
Misra, Deepika
Case Reports
Journal Article
BMJ Case Rep. 2017 Dec 14;2017:bcr2017222835. doi: 10.1136/bcr-2017-222835.
PY - 2017
SN - 1757-790x
ST - Cocaine-induced pseudo-Wellens' syndrome: a Wellens' phenocopy
T2 - BMJ Case Rep
TI - Cocaine-induced pseudo-Wellens' syndrome: a Wellens' phenocopy
VL - 2017
ID - 2859
ER -
TY - JOUR
AB - This study evaluated the association between atrial fibrillation (AF) and 30-
day clinical outcome in patients with acute ST-segment elevation myocardial
infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI).
Between January 2005 and October 2009, 783 consecutive patients with acute STEMI
undergoing primary PCI were enrolled. Of these patients, 85 (10.9%) with AF during
admission were categorized into group 1, while the remaining 698 (89.1%) with sinus
rhythm during admission served as group 2. The results demonstrated that the
incidence of advanced Killip score (defined as ≥ score 3) and advanced congestive
heart failure (defined as ≥ NYHA class 3) were significantly higher, whereas the
left ventricular ejection fraction (LVEF) was notably lower in group 1 than in
group 2 (all P < 0.003). Additionally, the normal blood flow in the infarct-related
artery was notably lower in group 1 than in group 2 (P = 0.003). Moreover, the
incidences of new-onset stroke and 30-day mortality were remarkably higher in group
1 than in group 2 (all P < 0.003). Furthermore, Kaplan-Meier analysis demonstrated
that the 30-day survival rate was markedly lower in AF patients than in those with
sinus rhythm. However, multivariate stepwise Cox regression analysis demonstrated
that the advanced Killip score and low LVEF were significantly and independently
predictive of 30-day mortality (all P < 0.004). In conclusion, AF was significantly
associated with 30-day mortality.
AD - Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial
Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine,
Kaohsiung, Taiwan, ROC.
AN - 21646737
AU - Lin, C. J.
AU - Liu, C. F.
AU - Kung, C. T.
AU - Sun, C. K.
AU - Lin, Y. C.
AU - Leu, S.
AU - Chua, S.
AU - Yeh, K. H.
AU - Wu, C. J.
AU - Chen, Y. L.
AU - Yip, H. K.
DO - 10.1536/ihj.52.153
DP - NLM
ET - 2011/06/08
IS - 3
KW - Aged
Female
Humans
Male
Middle Aged
Myocardial Infarction/complications/mortality/physiopathology/*therapy
Prognosis
Stroke/etiology
Treatment Outcome
LA - eng
N1 - 1349-3299
Lin, Cheng-Jei
Liu, Chu-Feng
Kung, Chia-Te
Sun, Cheuk-Kwan
Lin, Yu-Chun
Leu, Steve
Chua, Sarah
Yeh, Kuo-Ho
Wu, Chiung-Jen
Chen, Yung-Lung
Yip, Hon-Kan
Journal Article
Japan
Int Heart J. 2011;52(3):153-8. doi: 10.1536/ihj.52.153.
PY - 2011
SN - 1349-2365
SP - 153-8
ST - The prognostic value of atrial fibrillation on 30-day clinical outcome in
patients with ST-segment elevation myocardial infarction undergoing primary
T2 - Int Heart J
TI - The prognostic value of atrial fibrillation on 30-day clinical outcome in
patients with ST-segment elevation myocardial infarction undergoing primary
VL - 52
ID - 2737
ER -
TY - JOUR
AB - BACKGROUND: The impact of non-sustained ventricular tachycardia (NSVT) on the
risk of thromboembolic event and clinical outcomes in patients without structural
heart disease remains undetermined. This study aimed to evaluate the association
between NSVT and clinical outcomes. METHODS: The study population of 5903 patients
was culled from the "Registry of 24-hour ECG monitoring at Taipei Veterans General
Hospital" (REMOTE database) between January 1, 2002 and December 31, 2004. Of that
total, we enrolled 3767 patients without sustained ventricular tachycardia,
structural heart disease, and permanent pacemaker. For purposes of this study, NSVT
was defined as 3 or more consecutive beats arising below the atrioventricular node
with an RR interval of <600 ms (>100 beats/min) and lasting < 30 seconds. RESULT:
There were 776 deaths, 2042 hospitalizations for any reason, 638 cardiovascular
(CV)-related hospitalizations, 350 ischemic strokes, 409 transient ischemic
accident (TIA), 368 new-onset heart failure (HF), and 260 new-onset atrial
fibrillation (AF) with a mean follow-up duration of 10 ± 1 years. In multivariate
analysis, the presence of NSVT was independently associated with death (hazard
ratio [HR]: 1.362, 95% confidence interval [CI]: 1.071-1.731), CV hospitalization
(HR: 1.527, 95% CI: 1.171-1.992), ischemic stroke (HR: 1.436, 95% CI: 1.014-2.032),
TIA (HR 1.483, 95% CI: 1.069-2.057), and new-onset HF (HR: 1.716, 95% CI: 1.243-
2.368). There was no significant association between the presence of NSVT and all-
cause hospitalization or new-onset AF. CONCLUSION: In patients without structural
heart disease, presence of NSVT on 24-hour monitoring was independently associated
with death, CV hospitalization, ischemic stroke, TIA, and new onset heart failure.
AD - Division of Cardiology, Department of Medicine, Taipei Veterans General
Hospital, Taipei, Taiwan.
Department of Medicine, National Yang-Ming University School of Medicine, Taipei,
Taiwan.
Institute of Epidemiology and Preventive Medicine College of Public Health,
National Taiwan University, Taipei, Taiwan.
Division of Cardiology, Department of Internal Medicine, School of Medicine,
College of Medicine, Taipei Medical University, Taipei, Taiwan.
Division of Cardiology, National Yang-Ming University Hospital, Yi-Lan, Taiwan.
AN - 27548469
AU - Lin, C. Y.
AU - Chang, S. L.
AU - Chung, F. P.
AU - Chen, Y. Y.
AU - Lin, Y. J.
AU - Lo, L. W.
AU - Hu, Y. F.
AU - Tuan, T. C.
AU - Chao, T. F.
AU - Liao, J. N.
AU - Chang, Y. T.
AU - Lin, C. H.
AU - Allamsetty, S.
AU - Walia, R.
AU - Te, A. L.
AU - Yamada, S.
AU - Chiang, S. J.
AU - Tsao, H. M.
AU - Chen, S. A.
C2 - PMC4993359
DO - 10.1371/journal.pone.0160181
DP - NLM
ET - 2016/08/23
IS - 8
J2 - PloS one
KW - Aged
Atrial Fibrillation/*diagnostic imaging/etiology/mortality/physiopathology
Electrocardiography
Female
Follow-Up Studies
Heart
Heart Failure/*diagnostic imaging/etiology/mortality/physiopathology
Hospitalization
Humans
Male
Middle Aged
Myocardial Ischemia/*diagnostic imaging/etiology/mortality/physiopathology
*Registries
Risk Factors
Stroke/*diagnostic imaging/etiology/mortality/physiopathology
Tachycardia, Ventricular/complications/*diagnostic
Taiwan
Thromboembolism/*diagnostic imaging/etiology/mortality/physiopathology
LA - eng
N1 - 1932-6203
Lin, Chin-Yu
Chang, Shih-Lin
Chung, Fa-Po
Chen, Yun-Yu
Lin, Yenn-Jiang
Lo, Li-Wei
Hu, Yu-Feng
Tuan, Ta-Chuan
Chao, Tze-Fan
Liao, Jo-Nan
Chang, Yao-Ting
Lin, Chung-Hsing
Allamsetty, Suresh
Walia, Rohit
Te, Abigail Louise D
Yamada, Shinya
Chiang, Shuo-Ju
Tsao, Hsuan-Ming
Chen, Shih-Ann
Journal Article
Observational Study
PLoS One. 2016 Aug 22;11(8):e0160181. doi: 10.1371/journal.pone.0160181.
eCollection 2016.
PY - 2016
SN - 1932-6203
SP - e0160181
ST - Long-Term Outcome of Non-Sustained Ventricular Tachycardia in Structurally
Normal Hearts
T2 - PLoS One
TI - Long-Term Outcome of Non-Sustained Ventricular Tachycardia in Structurally
Normal Hearts
VL - 11
ID - 2547
ER -
TY - JOUR
AB - BACKGROUND: Cardiac resynchronisation therapy (CRT) improves outcomes in
selected patients with heart failure and left ventricular dysfunction. One
mechanism of benefit is believed to be favourable ventricular remodelling. Whether
CRT also decreases the frequency of ventricular arrhythmias and risk of sudden
death is unknown. OBJECTIVE: To determine the effect of CRT on frequency of
ventricular arrhythmias and appropriate ICD therapies. DESIGN: Retrospective cohort
study. SETTING: Single-centre, tertiary care facility (Mayo Clinic). PATIENTS: 52
patients (46 male), aged 70 (SD 10) years, who underwent upgrade from an
implantable cardioverter defibrillator (ICD) to a CRT-defibrillator were included.
INTERVENTIONS: Upgrade of ICD to CRT-defibrillator. MAIN OUTCOME MEASURES:
Frequency of ventricular arrhythmias prior to and following upgrade to CRT device.
RESULTS: Ejection fraction increased from 22% (SD 8%) to 27% (SD 11%) following
CRT. However, the frequency of non-sustained ventricular arrhythmias, sustained
ventricular arrhythmias, and ventricular fibrillation was not significantly changed
prior to and following CRT (2.38 (SD 9.78) vs 58.51 (SD 412.73) per patient per
month, p = 0.66; 0.07 (SD 0.17) vs 0.16 (SD 0.52), p = 0.70; 0.05 (SD 0.12) vs 0.25
(SD 1.40), p = 0.12). CONCLUSIONS: CRT is not associated with a decrease in the
frequency of ventricular arrhythmia or appropriate device therapy. Thus, use of CRT
alone is not beneficial in decreasing the frequency of ventricular arrhythmias or
the risk of appropriate ICD therapies.
AD - Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA.
AN - 17761506
AU - Lin, G.
AU - Rea, R. F.
AU - Hammill, S. C.
AU - Hayes, D. L.
AU - Brady, P. A.
DA - Feb
DO - 10.1136/hrt.2007.118372
DP - NLM
ET - 2007/09/01
IS - 2
KW - Aged
Arrhythmias, Cardiac/etiology/*prevention & control
Female
Heart Failure/*therapy
*Heart-Assist Devices
Humans
Male
Prosthesis Implantation/methods
Treatment Outcome
Ventricular Remodeling/physiology
LA - eng
N1 - 1468-201x
Lin, G
Rea, R F
Hammill, S C
Hayes, D L
Brady, P A
Journal Article
England
Heart. 2008 Feb;94(2):186-90. doi: 10.1136/hrt.2007.118372. Epub 2007 Aug 29.
PY - 2008
SN - 1355-6037
SP - 186-90
ST - Effect of cardiac resynchronisation therapy on occurrence of ventricular
arrhythmia in patients with implantable cardioverter defibrillators undergoing
upgrade to cardiac resynchronisation therapy devices
T2 - Heart
TI - Effect of cardiac resynchronisation therapy on occurrence of ventricular
arrhythmia in patients with implantable cardioverter defibrillators undergoing
upgrade to cardiac resynchronisation therapy devices
VL - 94
ID - 2516
ER -
TY - JOUR
AB - BACKGROUND: Previous studies have reported that the total bilirubin (TB)
level is associated with coronary artery disease, heart failure and atrial
fibrillation. These heart diseases can produce cardiogenic cerebral embolism and
cause cardioembolic stroke. However, whether the serum TB could be a biomarker to
differentiate cardioembolic stroke from other stroke subtypes is unclear. METHODS:
Our study consisted of 628 consecutive patients with ischaemic stroke. Various
clinical and laboratory variables of the patients were analysed according to serum
TB quartiles and stroke subtypes. RESULTS: The higher TB quartile group was
associated with atrial fibrillation, larger left atrium diameter, lower left
ventricular fractional shortening and cardioembolic stroke (P < 0.001, P = 0.001, P
= 0.033, P < 0.001, respectively). Furthermore, serum TB was a statistically
significant independent predictor of cardioembolic stroke in a multivariable
setting (Continuous, per unit increase OR = 1.091, 95%CI: 1.023-1.164, P = 0.008).
CONCLUSIONS: Serum TB level was independently associated with cardioembolic stroke.
The combination of clinical data and serum TB may be a feasible strategy to
diagnose cardioembolic stroke in the acute phase.
AN - 25891436
AU - Lin, S. P.
AU - Lin, P. Y.
AU - Jiang, H. L.
AU - Long, Y. M.
AU - Chen, X. H.
DA - Aug
DO - 10.1179/1743132815y.0000000038
DP - NLM
ET - 2015/04/22
IS - 8
J2 - Neurological research
KW - Adult
Aged
Aged, 80 and over
Atrial Fibrillation/blood/pathology
Bilirubin/*blood
Biomarkers/blood
Brain Ischemia/blood/classification/*diagnosis/etiology/pathology
Feasibility Studies
Female
Humans
Intracranial Embolism/blood/complications/*diagnosis/pathology
Male
Middle Aged
Stroke/blood/classification/*diagnosis/etiology/pathology
Aetiology
Cardiovascular diseases
Ischaemic stroke
Total bilirubin
LA - eng
N1 - 1743-1328
Lin, Shao-Peng
Lin, Pei-Yi
Jiang, Hui-Lin
Long, You-Ming
Chen, Xiao-Hui
Journal Article
England
Neurol Res. 2015 Aug;37(8):727-31. doi: 10.1179/1743132815Y.0000000038. Epub 2015
Apr 18.
PY - 2015
SN - 0161-6412
SP - 727-31
ST - Is serum total bilirubin useful to differentiate cardioembolic stroke from
other stroke subtypes?
T2 - Neurol Res
TI - Is serum total bilirubin useful to differentiate cardioembolic stroke from
other stroke subtypes?
VL - 37
ID - 2370
ER -
TY - JOUR
AB - BACKGROUND: The aim of the present study was to identify the long-term major
adverse cardiovascular events (MACE) in adult congenital heart disease (ConHD)
patients in Taiwan. METHODS: From the National Health Insurance Research Database
(1997-2010), adult patients (≥18 years) with ConHD were identified and compared to
non-ConHD control patients. The primary end point was the incidence of MACE. Cox
proportional hazards models were used to compute hazard ratios as estimates for
multivariate adjusted relative risks with or without adjusting for age and sex.
RESULTS: A total of 3,267 adult patients with ConHD were identified between 2000
and 2003 with a median follow-up of 11 years till December 31, 2010. The five most
common types of ConHD were atrial septal defects, ventricular septal defects,
patent ductus arteriosus, tetralogy of Fallot, and pulmonary stenosis. Overall, the
incidence of MACE was 4.0-fold higher in the ConHD group compared with the
controls. After adjustment for age and gender, the patients with ConHD had an
increased risk of heart failure, malignant dysrhythmia, acute coronary syndrome,
and stroke. The adult ConHD patients had a decreased life-long risk of MACE if they
received surgical correction, especially in the patients with atrial septal
defects. CONCLUSIONS: After a median of 11 years of follow-up, the Taiwanese
patients with ConHD were at an increased risk of life-long cardiovascular MACE,
including heart failure, stroke, acute coronary syndrome, and malignant
dysrhythmia. Surgical correction may help to decrease long-term MACE in ConHD
patients, especially those with ASD.
AD - Department of Cardiology, Chang Gung Memorial Hospital and Chang Gung
University, Taipei, Taiwan. cjchang@mail.cgu.edu.tw.
AN - 24655794
AU - Lin, Y. S.
AU - Liu, P. H.
AU - Wu, L. S.
AU - Chen, Y. M.
AU - Chang, C. J.
AU - Chu, P. H.
C2 - PMC3994523
DA - Mar 21
DO - 10.1186/1471-2261-14-38
DP - NLM
ET - 2014/03/25
KW - Acute Coronary Syndrome/diagnosis/*epidemiology
Adolescent
Adult
Age Factors
Arrhythmias, Cardiac/diagnosis/*epidemiology
Female
Follow-Up Studies
Heart Defects, Congenital/diagnosis/*epidemiology/surgery
Heart Failure/diagnosis/*epidemiology
Humans
Incidence
Male
Prognosis
Risk Factors
Sex Factors
Stroke/diagnosis/*epidemiology
Taiwan/epidemiology
Time Factors
Young Adult
LA - eng
N1 - 1471-2261
Lin, Yu-Sheng
Liu, Pi-Hua
Wu, Lung-Sheng
Chen, Yu-Ming
Chang, Chee-Jen
Chu, Pao-Hsien
Journal Article
BMC Cardiovasc Disord. 2014 Mar 21;14:38. doi: 10.1186/1471-2261-14-38.
PY - 2014
SN - 1471-2261
SP - 38
ST - Major adverse cardiovascular events in adult congenital heart disease: a
population-based follow-up study from Taiwan
TI - Major adverse cardiovascular events in adult congenital heart disease: a
population-based follow-up study from Taiwan
VL - 14
ID - 2610
ER -
TY - JOUR
AB - Decision making with regard to thromboprophylaxis should be based upon the
absolute risks of stroke/thromboembolism and bleeding and the net clinical benefit
for a given patient. As a consequence, a crucial part of atrial fibrillation (AF)
management requires the appropriate use of thromboprophylaxis, and the assessment
of stroke as well as bleeding risk can help inform management decisions by
clinicians. The objective of this review article is to provide an overview of
stroke and bleeding risk assessment in AF. There would be particular emphasis on
when, how, and why to use these risk stratification schemes, with a specific focus
on the CHADS2 [congestive heart failure, hypertension, age, diabetes, stroke
(doubled)], CHA2DS2-VASc [congestive heart failure or left ventricular dysfunction,
hypertension, age ≥ 75 (doubled), diabetes, stroke (doubled)-vascular disease, age
65-74 and sex category (female)], and HAS-BLED [hypertension (i.e. uncontrolled
blood pressure), abnormal renal/liver function, stroke, bleeding history or
predisposition, labile INR (if on warfarin), elderly (e.g. age >65, frail
condition), drugs (e.g. aspirin, NSAIDs)/alcohol concomitantly] risk scores.
Birmingham B18 7QH, UK.
AN - 23257951
AU - Lip, G. Y.
DA - Apr
DO - 10.1093/eurheartj/ehs435
DP - NLM
ET - 2012/12/22
IS - 14
KW - Aged
Biomarkers/blood
Echocardiography
Female
Hemorrhage/*prevention & control
Humans
Male
Renal Insufficiency/etiology
Risk Assessment
Risk Factors
Vitamin K/antagonists & inhibitors
LA - eng
N1 - 1522-9645
Lip, Gregory Y H
Journal Article
Review
England
Eur Heart J. 2013 Apr;34(14):1041-9. doi: 10.1093/eurheartj/ehs435. Epub 2012 Dec
20.
PY - 2013
SN - 0195-668x
SP - 1041-9
ST - Stroke and bleeding risk assessment in atrial fibrillation: when, how, and
why?
T2 - Eur Heart J
TI - Stroke and bleeding risk assessment in atrial fibrillation: when, how, and
why?
VL - 34
ID - 2797
ER -
TY - JOUR
AB - BACKGROUND: The renin-angiotensin-aldosterone-system (RAAS) plays an
important role in atrial fibrillation (AF). Evidence shows that blocking the RAAS
with angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor
blockers (ARBs) has a definite role in preventing new onset AF and in maintaining
sinus rhythm in recurrent AF. Our aim was to determine if ACEI/ARB treatment was
associated with clinical outcomes [stroke/systemic embolic events (SEE), mortality]
in a controlled, anticoagulated AF population. METHODS: An ancillary retrospective
cross-sectional and longitudinal analysis of participants in the Stroke Prevention
using an ORal Thrombin Inhibitor in AF (SPORTIF) III and V trials, in relation to
use (or nonuse) of ACEI/ARBs. RESULTS: Rates of stroke/SEEs, mortality or major
bleeding were no different between users and nonusers in the whole cohort, or in
relation to the presence/absence of hypertension, coronary artery disease and
previous stroke/transient ischaemic attack, nor amongst those aged <75 years.
Patients aged > or = 75 years taking ACEIs or ARBs had lower mortality (HR 0.71,
95% CI 0.52-0.95), but no significant influence on other end-points was noted.
Diabetics and those with left ventricular dysfunction on ximelagatran had a higher
odds ratio of abnormal liver enzyme levels. There was no apparent benefit of ACEIs
or ARBs on other event rates. CONCLUSIONS: This analysis from two large randomized
trials of anticoagulation has not demonstrated a significant benefit of ACEI or ARB
use amongst AF patients, except amongst elderly subjects.
AD - Haemostasis Thrombosis and Vascular Biology Unit, University Department of
Medicine, City Hospital, Birmingham, UK. g.y.h.lip@bham.ac.uk
AN - 17547713
AU - Lip, G. Y.
AU - Frison, L.
AU - Grind, M.
DA - Jun
DO - 10.1111/j.1365-2796.2007.01780.x
DP - NLM
ET - 2007/06/06
IS - 6
J2 - Journal of internal medicine
KW - Aged
*Angiotensin Receptor Antagonists
Female
Humans
Male
Middle Aged
Risk Factors
Treatment Outcome
LA - eng
N1 - Lip, G Y H
Frison, L
Grind, M
Journal Article
England
J Intern Med. 2007 Jun;261(6):577-86. doi: 10.1111/j.1365-2796.2007.01780.x.
PY - 2007
SN - 0954-6820 (Print)
0954-6820
SP - 577-86
ST - Angiotensin converting enzyme inhibitor and angiotensin receptor blockade use
in relation to outcomes in anticoagulated patients with atrial fibrillation
T2 - J Intern Med
TI - Angiotensin converting enzyme inhibitor and angiotensin receptor blockade use
in relation to outcomes in anticoagulated patients with atrial fibrillation
VL - 261
ID - 2603
ER -
TY - JOUR
AB - OBJECTIVES: The purpose of this study was to investigate predictors of
bleeding in a cohort of anticoagulated patients and to evaluate the predictive
value of several bleeding risk stratification schemas. BACKGROUND: The risk of
bleeding during antithrombotic therapy in patients with atrial fibrillation (AF) is
not homogeneous, and several clinical risk factors have been incorporated into
clinical bleeding risk stratification schemas. Current risk stratification schemas
for bleeding during anticoagulation therapy have been based on complex scoring
systems that are difficult to apply in clinical practice, and few have been derived
and validated in AF cohorts. METHODS: We investigated predictors of bleeding in a
cohort of 7,329 patients with AF participating in the SPORTIF (Stroke Prevention
Using an ORal Thrombin Inhibitor in Atrial Fibrillation) III and V clinical trials
and evaluated the predictive value of several risk stratification schemas by
multivariate analysis. Patients were anticoagulated orally with either adjusted-
dose warfarin (target international normalized ratio 2 to 3) or fixed-dose
ximelagatran 36 mg twice daily. Major bleeding was centrally adjudicated, and
concurrent aspirin therapy was allowed in patients with clinical atherosclerosis.
RESULTS: By multivariate analyses, significant predictors of bleeding were
concurrent aspirin use (hazard ratio [HR]: 2.10; 95% confidence interval [CI]: 1.59
to 2.77; p < 0.001); renal impairment (HR: 1.98; 95% CI: 1.42 to 2.76; p < 0.001);
age 75 years or older (HR: 1.63; 95% CI: 1.23 to 2.17; p = 0.0008); diabetes (HR:
1.47; 95% CI: 1.10 to 1.97; p = 0.009), and heart failure or left ventricular
dysfunction (HR: 1.32; 95% CI: 1.01 to 1.73; p = 0.041). Of the tested schemas, the
new HAS-BLED (Hypertension, Abnormal Renal/Liver Function, Stroke, Bleeding History
or Predisposition, Labile INR, Elderly, Drugs/Alcohol Concomitantly) score
performed best, with a stepwise increase in rates of major bleeding with increasing
HAS-BLED score (p(trend) <0.0001). The c statistic for bleeding varied between 0.50
and 0.67 in the overall entire cohort and 0.68 among patients naive to warfarin at
baseline (n = 769). CONCLUSIONS: This analysis identifies diabetes and heart
failure or left ventricular dysfunction as potential risk factors for bleeding in
AF beyond those previously recognized. Of the contemporary bleeding risk
stratification schemas, the new HAS-BLED scheme offers useful predictive capacity
for bleeding over previously published schemas and may be simpler to apply.
Birmingham, England. g.y.h.lip@bham.ac.uk
AN - 21111555
AU - Lip, G. Y.
AU - Frison, L.
AU - Lane, D. A.
DA - Jan 11
DO - 10.1016/j.jacc.2010.09.024
DP - NLM
ET - 2010/11/30
IS - 2
KW - Aged
Anticoagulants/*adverse effects/therapeutic use
Atrial Fibrillation/blood/*drug therapy
Azetidines/adverse effects/therapeutic use
Benzylamines/adverse effects/therapeutic use
Blood Coagulation/drug effects
Double-Blind Method
Female
Follow-Up Studies
Hemorrhage/blood/*chemically induced/epidemiology
Humans
Male
Prognosis
Risk Factors
Warfarin/adverse effects/therapeutic use
LA - eng
N1 - 1558-3597
Lip, Gregory Y H
Frison, Lars
Lane, Deirdre A
Clinical Trial, Phase III
Comparative Study
Journal Article
Multicenter Study
United States
J Am Coll Cardiol. 2011 Jan 11;57(2):173-80. doi: 10.1016/j.jacc.2010.09.024. Epub
2010 Nov 24.
PY - 2011
SN - 0735-1097
SP - 173-80
ST - Comparative validation of a novel risk score for predicting bleeding risk in
anticoagulated patients with atrial fibrillation: the HAS-BLED (Hypertension,
Abnormal Renal/Liver Function, Stroke, Bleeding History or Predisposition, Labile
INR, Elderly, Drugs/Alcohol Concomitantly) score
TI - Comparative validation of a novel risk score for predicting bleeding risk in
anticoagulated patients with atrial fibrillation: the HAS-BLED (Hypertension,
Abnormal Renal/Liver Function, Stroke, Bleeding History or Predisposition, Labile
INR, Elderly, Drugs/Alcohol Concomitantly) score
VL - 57
ID - 2799
ER -
TY - JOUR
AB - There has been a tendency to treat paroxysmal atrial fibrillation (PAF) in a
similar way to sustained AF, but treatment objectives may be very different. We
discuss current definitions, epidemiology, pathophysiology and natural history of
PAF, and review evidence for its treatment and management. PAF comprises between
25% and 62% of cases of AF, with similar underlying causes to those in sustained
AF. The main objective of management is prevention of paroxysms and long-term
maintenance of sinus rhythm, and Class 1c drugs are highly effective, although
beta-blockers are useful alternatives. If patients have severe coronary artery
disease or poor ventricular function, amiodarone is probably the drug of choice.
Although randomized controlled trials of thromboprophylaxis in patients with
paroxysmal AF per se are lacking, the approach to patients with paroxysmal AF
should be similar to that in patients with sustained AF, with warfarin for 'high
risk' patients and aspirin for those at 'low risk'. Non-pharmacological therapeutic
options, including pacemakers, electrophysiological techniques and the implantable
atrial defibrillator, show great promise. Despite paroxysmal AF being a common
condition, management strategies are limited by evidence from small randomized
trials, with inconsistencies over the definition of the arrhythmia and the
inclusion of only symptomatic subjects. Evidence for antithrombotic therapy is also
based on epidemiological studies and subgroup analyses of the large randomized
trials.
AD - Haemostasis, Thrombosis and Vascular Biology Unit, University Department of
Medicine, City Hospital, Birmingham, UK. G.Y.H.LIP@bham.ac.uk
AN - 11744787
AU - Lip, G. Y.
AU - Hee, F. L.
DA - Dec
DO - 10.1093/qjmed/94.12.665
DP - NLM
ET - 2001/12/18
IS - 12
J2 - QJM : monthly journal of the Association of Physicians
Aged
Atrial Fibrillation/complications/physiopathology/*therapy
Catheter Ablation
Electrocardiography
Female
Humans
Male
Stroke/etiology
LA - eng
N1 - Lip, G Y
Hee, F L
Journal Article
Review
England
QJM. 2001 Dec;94(12):665-78. doi: 10.1093/qjmed/94.12.665.
PY - 2001
SN - 1460-2725 (Print)
1460-2393
SP - 665-78
ST - Paroxysmal atrial fibrillation
T2 - Qjm
TI - Paroxysmal atrial fibrillation
VL - 94
ID - 2415
ER -
TY - JOUR
AB - OBJECTIVE: To examine further the relations of plasma von Willebrand factor
(vWf, an index of endothelial damage and dysfunction) and soluble P-selectin (sP-
sel, an index of platelet activation) concentrations to the presence and onset of
clinical congestive heart failure (CHF) and the degree of left ventricular (LV)
dysfunction in patients taking part in the SPAF (stroke prevention in atrial
fibrillation) study. METHODS: Plasma concentrations of vWf and sP-sel were measured
by enzyme linked immunosorbent assay (ELISA) in 1321 participants in the SPAF III
study and related to the presence and onset of clinical CHF, as well as
echocardiographic findings. Of the 1321 patients with atrial fibrillation (AF), 331
(25%) had a documented history of clinical heart failure, of which 168 cases were
related to a new or recurrent episode of acute decompensated heart failure
occurring within the preceding three months. RESULTS: Mean plasma vWf was higher
among patients with AF and CHF (154 (29) v 144 (31) IU/dl, p < 0.001), particularly
those with acute or recent decompensated symptoms. Patients with severe LV
dysfunction on two dimensional echocardiography and low fractional shortening also
had significantly higher vWf concentrations than those with no LV dysfunction. CHF
patients with clinical features--with (156 (28) IU/dl) and without (152 (31) IU/dl)
LV dysfunction--also had higher mean vWf concentrations than patients with
asymptomatic LV dysfunction (146 (31) IU/dl, p < 0.001). The presence of mitral
regurgitation in CHF was associated with lower vWf concentrations. Plasma sP-sel
concentrations were not affected by presence, onset, or severity of heart failure.
CONCLUSIONS: CHF may contribute to hypercoagulability and thrombotic risk in AF
through increased endothelial damage and dysfunction. Patients with acute or recent
decompensated features have the highest degree of endothelial damage and
dysfunction. The presence of CHF clinical features was an important determinant of
plasma vWf concentrations.
AD - Haemostasis Thrombosis and Vascular Biology Unit, University Department of
Medicine, City Hospital, Birmingham, UK. g.y.h.lip@bham.ac.uk
AN - 15894770
AU - Lip, G. Y.
AU - Pearce, L. A.
AU - Chin, B. S.
AU - Conway, D. S.
AU - Hart, R. G.
C2 - PMC1768962
DA - Jun
DO - 10.1136/hrt.2004.036160
DP - NLM
ET - 2005/05/17
IS - 6
KW - Aged
Atrial Fibrillation/*blood
Female
Heart Failure/*blood/drug therapy
Humans
Male
P-Selectin/*analysis
Platelet Aggregation Inhibitors/administration & dosage
Risk Factors
Stroke/blood/prevention & control
Ventricular Dysfunction, Left/blood
Warfarin/administration & dosage
von Willebrand Factor/*analysis
LA - eng
N1 - 1468-201x
Lip, G Y H
Pearce, L A
Chin, B S P
Conway, D S G
Hart, R G
Clinical Trial
Journal Article
Multicenter Study
Heart. 2005 Jun;91(6):759-63. doi: 10.1136/hrt.2004.036160.
PY - 2005
SN - 1355-6037 (Print)
1355-6037
SP - 759-63
ST - Effects of congestive heart failure on plasma von Willebrand factor and
soluble P-selectin concentrations in patients with non-valvar atrial fibrillation
T2 - Heart
TI - Effects of congestive heart failure on plasma von Willebrand factor and
soluble P-selectin concentrations in patients with non-valvar atrial fibrillation
VL - 91
ID - 2793
ER -
TY - JOUR
AB - BACKGROUND: The aim of the current analysis was to identify independent
predictors of the overall clinical outcome of patients with atrial fibrillation
(AF), including both stroke/thromboembolism and/or major bleeding. Given the
overlap between stroke and bleeding risk factors, a composite risk-stratification
score for stroke/thromboembolism or bleeding could potentially be developed.
METHODS: We used data from the vitamin K antagonist (VKA) arm (n = 2,293; 65% men;
mean age 70 ± 9 years) of the AMADEUS (Evaluating the Use of SR34006 Compared to
Warfarin or Acenocoumarol in Patients With Atrial Fibrillation) trial, which was a
multicenter, randomized, open-label noninferiority study that compared fixed-dose
idraparinux with VKA in patients with AF. We defined two composite end points: end
point 1 was the combination of stroke/thromboembolism or major bleeding; end point
2 was defined as the combination of stroke, systemic or venous embolism, myocardial
infarction, cardiovascular death, or major bleeding. RESULTS: The independent
predictors for composite end point 1 were age (P = .014), previous stroke/transient
ischemic attack (P = .049), aspirin use (P = .002), and time in therapeutic range
(P = .007). For composite end point 2, similar predictors were evident, plus left
ventricular dysfunction (P = .011). Based on the regression models, two novel
composite risk-prediction scores were developed and were validated externally in a
"real-world" cohort of 441 outpatients with AF receiving anticoagulation treatment.
Both composite scores 1 and 2 demonstrated numerically higher discriminatory
performance (area under the curve [AUC], 0.728; 95% CI, 0.659-0.798 and AUC, 0.707;
95% CI, 0.655-0.758, for end points 1 and 2, respectively) and a positive net
reclassification when compared with currently used risk models (CHADS2 [congestive
heart failure, hypertension, age ≥ 75 years, diabetes, prior stroke or transient
ischemic attack], CHA2DS2VASc [cardiac failure or dysfunction, hypertension, age ≥
75 years [doubled], diabetes, stroke (doubled)-vascular disease, age 65 to 74
years, and sex category (female)], and HAS-BLED [hypertension, abnormal renal/liver
function, stroke, bleeding history or predisposition, labile international
normalized ratio, elderly, drugs/alcohol concomitantly]), but the differences were
not statistically significant. CONCLUSIONS: We have developed and validated two
novel composite scores for stroke/thromboembolism/bleeding that offer good
discriminatory and predictive performance. However, these composite risk scores did
not perform better than the easier and more practical "traditional" stroke and
bleeding risk scores that are currently in use, which allow greater practicality
and a more personalized balancing of risks.
Birmingham, England. Electronic address: g.y.h.lip@bham.ac.uk.
Birmingham, England.
Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The
Netherlands.
AN - 24009027
AU - Lip, G. Y. H.
AU - Lane, D. A.
AU - Buller, H.
DA - Dec
DO - 10.1378/chest.13-1635
DP - NLM
ET - 2013/09/07
IS - 6
J2 - Chest
KW - Acenocoumarol/*adverse effects/therapeutic use
Aged
Aged, 80 and over
Anticoagulants/adverse effects/therapeutic use
Antithrombins/adverse effects/therapeutic use
Area Under Curve
Female
Hemorrhage/*epidemiology
Humans
Male
Middle Aged
Models, Statistical
Oligosaccharides/*adverse effects/therapeutic use
Regression Analysis
Risk Factors
Warfarin/*adverse effects/therapeutic use
LA - eng
N1 - 1931-3543
Lip, Gregory Y H
Lane, Deirdre A
Buller, Harry
Journal Article
Multicenter Study
United States
Chest. 2013 Dec;144(6):1839-1847. doi: 10.1378/chest.13-1635.
PY - 2013
SN - 0012-3692
SP - 1839-1847
ST - Development of a novel composite stroke and bleeding risk score in patients
with atrial fibrillation: the AMADEUS Study
T2 - Chest
TI - Development of a novel composite stroke and bleeding risk score in patients
with atrial fibrillation: the AMADEUS Study
VL - 144
ID - 2914
ER -
TY - JOUR
AB - Objective: To observe the long-term prognosis and related outcome predictors
for hypertrophic obstructive cadiomyopathy (HOCM) patients underwent alcohol septal
ablation (ASA). Methods: A total of 227 consecutive patients(age: (47.8±11.7)
years) treated by ASA from September 2005 to December 2013 in our hospital were
included and followed-up for 4.42 years(range: ( 1.17-9.93) years). Follow up rate
is 97.4%(221/227). General information, medical history, data of ASA and
complications during hospitalization were obtained through access to medical
records of patients. The patients were followed up by telephone or outpatient
visit. Results: During hospitalization period, one patient died due to
retroperitoneal hemorrhage, two ventricular fibrillation events and two sustained
ventricular tachycardia events occurred and all patients were successfully
recovered after electrical cardioversion (defibrillation). Four cardiac tamponade
events occurred, 35.7% (81/227) patients experienced temporary three degree
atrioventricular block. Five delayed three degree atrioventricular block evens
occurred. During follow up, the percent of NYHA Ⅲ/Ⅳclass was significantly
reduced (10.1%(23/227)vs. 74.9%(170/227), P=0.000). The incidence of syncope and
amaurosis fugax was also reduced(2.6% (6/227) vs. 39.2% (89/227), P=0.035). A total
of six patients died (4 cardiac death), one patient complicating atrial
fibrillation died of cerebral embolism, one patient died of rectal cancer. One
cerebral hemorrhage occurred. Six patients developed-new onset atrial fibrillation.
One patient received permanent pacemaker implantation. Eight patients received
surgical myocardial resection. Three patients underwent repeated ASA. Survival free
of all-cause mortality at 1, 5, 9 year was 100%, 96%, 96%, respectively. Survival
free of cardiac death and NYHA Ⅲ/Ⅳclass at 1, 5, 9 year was 100%, 86%, 70%,
respectively. Cox-regression analysis showed that residual left ventricular outflow
tract gradient after ablation(HR=1.027, 95%CI 1.006-1.048, P=0.010), less volume of
injected ethanol(HR=0.596, 95%CI 0.398-0.892, P=0.012), presence of temporary
complete atrioventricular block (HR=0.332, 95%CI 0.124-0.886, P=0.028)were
independent predictors of cardiac death and NYHA Ⅲ/Ⅳ. Conclusion: Our study
results suggest that ASA could significantly improve symptoms and outcome in
patients with HOCM. Residual left ventricular outflow tract gradient after
ablation, less volume of injected ethanol, presence of temporary complete
atrioventricular block during ASA are independent predictors of cardiac death and
NYHA Ⅲ/Ⅳ.
AD - Coronary Heart Disease Research Center, Fuwai Hospital, National Center for
Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union
Medical College, Beijing 100037, China.
AN - 27667275
AU - Liu, R.
AU - Qiao, S. B.
AU - Hu, F. H.
AU - Yang, W. X.
AU - Yuan, J. S.
AU - Cui, J. G.
DA - Sep 24
DO - 10.3760/cma.j.issn.0253-3758.2016.09.008
DP - NLM
ET - 2016/09/27
IS - 9
J2 - Zhonghua xin xue guan bing za zhi
KW - Atrioventricular Block
*Cardiomyopathy, Hypertrophic
Ethanol
Heart Septum
Heart Ventricles
Humans
Middle Aged
Time Factors
Treatment Outcome
Ventricular Fibrillation
LA - chi
N1 - Liu, R
Qiao, S B
Hu, F H
Yang, W X
Yuan, J S
Cui, J G
Journal Article
China
Zhonghua Xin Xue Guan Bing Za Zhi. 2016 Sep 24;44(9):771-776. doi:
10.3760/cma.j.issn.0253-3758.2016.09.008.
PY - 2016
SN - 0253-3758 (Print)
0253-3758
SP - 771-776
ST - [Long-term outcome and related predictors of alcohol septal ablation for
patients with hypertrophic obstructive cardiomyopathy]
T2 - Zhonghua Xin Xue Guan Bing Za Zhi
TI - [Long-term outcome and related predictors of alcohol septal ablation for
patients with hypertrophic obstructive cardiomyopathy]
VL - 44
ID - 2825
ER -
TY - JOUR
AB - PURPOSE OF REVIEW: This review will discuss the most frequent sources of
cardiac embolism and the role of echocardiography in these different clinical
settings, and, in addition, provide suggestions about the choice between
transthoracic (TTE) and transesophageal echocardiography (TEE). RECENT FINDINGS:
Stroke is the third leading cause of death in industrial countries, and 15-40% of
all ischemic strokes are due to cardioembolism. TTE and TEE are cornerstones in the
detection of cardioembolic sources and provide fundamental information about the
embolic risk and most suitable treatment of these patients, improving long-term
outcomes. Echocardiography is a widely available, inexpensive, and safe diagnostic
tool that is almost free from contraindication, and these elements allow the common
use of this technique in almost all the patients with ischemic stroke. The most
common cardioembolic sources include left atrial appendage thrombosis during atrial
fibrillation; vegetations in infective endocarditis; cardiac masses including left
ventricular thrombosis, cardiac tumors, etc.; atherosclerotic plaques; and
passageways within the heart serving as conduits for paradoxical embolization,
e.g., patent foramen ovale.
AD - Department of Clinical and Experimental Medicine - Section of Cardiology,
University of Messina, Azienda Ospedaliera Universitaria "Policlinico G. Martino"
and Universita' degli Studi di Messina, Via Consolare Valeria n.12, 98100, Messina,
Italy.
Aurora Cardiovascular Services, Aurora Sinai/Aurora St. Luke's Medical Centers,
2801 W. Kinnickinnic River Parkway, Ste. 880, Milwaukee, WI, 53215, USA.
Aurora Cardiovascular Services, Aurora Sinai/Aurora St. Luke's Medical Centers,
2801 W. Kinnickinnic River Parkway, Ste. 880, Milwaukee, WI, 53215, USA.
publishing22@aurora.org.
Marcus Family Fund for Echocardiography (ECHO) Research and Education, 2801 W.
Kinnickinnic River Parkway, Ste. 880, Milwaukee, WI, 53215, USA.
publishing22@aurora.org.
AN - 30310999
AU - Longobardo, L.
AU - Zito, C.
AU - Carerj, S.
AU - Caracciolo, G.
AU - Umland, M.
AU - Khandheria, B. K.
DA - Oct 11
DO - 10.1007/s11886-018-1085-5
DP - NLM
ET - 2018/10/13
IS - 12
J2 - Current cardiology reports
KW - Atrial Fibrillation/complications/*diagnostic imaging
Brain Ischemia/etiology/prevention & control
*Echocardiography
Endocarditis/complications/diagnostic imaging
Foramen Ovale, Patent/complications/*diagnostic imaging
Heart Neoplasms/complications/*diagnostic imaging
Humans
*Cardioembolic sources
*Endocarditis
*Stroke
*Thrombus
LA - eng
N1 - 1534-3170
Longobardo, Luca
Zito, Concetta
Carerj, Scipione
Caracciolo, Giuseppe
Umland, Matt
Khandheria, Bijoy K
Journal Article
Review
United States
Curr Cardiol Rep. 2018 Oct 11;20(12):136. doi: 10.1007/s11886-018-1085-5.
PY - 2018
SN - 1523-3782
SP - 136
ST - Role of Echocardiography in Assessment of Cardioembolic Sources: a Strong
Diagnostic Resource in Patients with Ischemic Stroke
T2 - Curr Cardiol Rep
TI - Role of Echocardiography in Assessment of Cardioembolic Sources: a Strong
Diagnostic Resource in Patients with Ischemic Stroke
VL - 20
ID - 2325
ER -
TY - JOUR
AB - Atrial fibrillation is the cardiac arrhythmia encountered most often in
clinical practice. It is triggered by many conditions such as thyroid dysfunction,
cardiac disease, alcohol, and pulmonary disease. Patients with chronic obstructive
pulmonary disease (COPD) are susceptible to many insults that can lead to an acute
deterioration superimposed on chronic disease. Changes in blood gases,
abnormalities in pulmonary functions, and hemodynamic changes resulting from
pulmonary hypertension can lead to the development of atrial fibrillation. Atrial
fibrillation and COPD frequently coexist and complicate treatment of both
conditions. The treatment of COPD exacerbation may include beta-adrenergic agonist
and theophylline, which can precipitate atrial fibrillation with rapid ventricular
response. Pharmacologic and electrical cardioversion may be ineffective in the
management of atrial fibrillation in patients with COPD until respiratory
decompensation has been corrected. This article focuses on the management of atrial
fibrillation in patients with COPD.
AD - Interventional Cardiology Group, The Heart and Vascular Cardiology Group,
Tampa, FL, USA.
AN - 15855862
AU - Lopez, C. M.
AU - House-Fancher, M. A.
DA - Mar-Apr
DO - 10.1097/00005082-200503000-00009
DP - NLM
ET - 2005/04/28
IS - 2
J2 - The Journal of cardiovascular nursing
Atrial Fibrillation/diagnosis/*drug therapy/etiology
Humans
Pulmonary Disease, Chronic Obstructive/*complications/physiopathology
LA - eng
N1 - Lopez, Carmen M
House-Fancher, Mary Ann
Journal Article
Review
United States
J Cardiovasc Nurs. 2005 Mar-Apr;20(2):133-40. doi: 10.1097/00005082-200503000-
00009.
PY - 2005
SN - 0889-4655 (Print)
0889-4655
SP - 133-40
ST - Management of atrial fibrillation in patients with chronic obstructive
pulmonary disease
T2 - J Cardiovasc Nurs
TI - Management of atrial fibrillation in patients with chronic obstructive
pulmonary disease
VL - 20
ID - 2490
ER -
TY - JOUR
AB - A 55-year-old man with liver cancer underwent partial hepatectomy under
combined lumbar epidural and general anesthesia. Asystole during postoperative
recovery was followed by ventricular fibrillation. After unsuccessful
cardiopulmonary resuscitation efforts, brain death was diagnosed. In the absence of
anemia, acidosis, electrolytic alterations or hypothermia, and after ruling out
hemoperitoneum, acute myocardial infarction and stroke, we conclude that the
clinical picture described was the result of autonomic imbalance due to spreading
of the sympathetic block.
AD - Servicio de Anestesiología, Reanimación y Terapéutica del Dolor, Hospital de
Sabadell-Corporació Parc Taulí Parc Taulí s/n, 08208 Sabadell, Barcelona.
AN - 12353412
AU - López Galera, S.
AU - Fernández Galinski, D.
AU - Echevarria Martín, J.
AU - Aguilar Sánchez, J. L.
DA - Jun-Jul
DP - NLM
ET - 2002/10/02
IS - 6
J2 - Revista espanola de anestesiologia y reanimacion
KW - Anesthesia, Epidural/*adverse effects
Anesthesia, Inhalation/*adverse effects
Anesthetics, Local/*adverse effects/pharmacokinetics
Atracurium
Brain Death
Bupivacaine/*adverse effects/pharmacokinetics
Carcinoma, Hepatocellular/*surgery
Elective Surgical Procedures
Fatal Outcome
Fentanyl
Heart Arrest/*chemically induced/complications
Hepatectomy/*methods
Humans
Isoflurane
Liver Neoplasms/*surgery
Lumbosacral Region
Male
Midazolam
Middle Aged
Morphine/administration & dosage/adverse effects
Postoperative Complications/*chemically induced
Propofol
Reflex
Ventricular Fibrillation/*etiology
LA - spa
N1 - López Galera, S
Fernández Galinski, D
Echevarria Martín, J
Aguilar Sánchez, J L
Case Reports
Journal Article
Spain
Rev Esp Anestesiol Reanim. 2002 Jun-Jul;49(6):334-6.
OP - Asistolia después de anestesia combinada.
PY - 2002
SN - 0034-9356 (Print)
0034-9356
SP - 334-6
ST - [Asystole after combination anesthesia]
T2 - Rev Esp Anestesiol Reanim
TI - [Asystole after combination anesthesia]
VL - 49
ID - 3053
ER -
TY - JOUR
AB - Transient atrioventricular (1st-degree and 2nd-degree (type II) block,
coronary node rhythm, dissociation) and intraventricular (left anterior hemiblock)
disturbance were noted in a 67-yr-old man with acute cerebral thrombosis. It is
suggested that one of more of the following factors were responsible from time to
time for these unusual ECG signs: disturbance of neurovegetative regulation with
predominant vagal hypertonus, circulation deficiencies in the conduction tissue due
to decreased cardiac output, and histological lesion of specific tissue.
AN - 1161175
AU - Lovreglio, V.
AU - De Cesare, B. L.
AU - Sannito, N.
DA - Sep 5
DP - NLM
ET - 1975/09/05
IS - 57
J2 - Minerva medica
KW - Acute Disease
Aged
Heart Block/*etiology
Heart Ventricles
Humans
Intracranial Embolism and Thrombosis/*complications
Male
LA - ita
N1 - Lovreglio, V
De Cesare, B L
Sannito, N
English Abstract
Journal Article
Italy
Minerva Med. 1975 Sep 5;66(57):2877-81.
OP - Turbe della conduzione atrio-ventricolare e intra-ventricolare in un caso di
cerebropatia vascolare acuta.
PY - 1975
SN - 0026-4806 (Print)
0026-4806
SP - 2877-81
ST - [Atrio-ventricular and intra-ventricular conduction disorders in a case of
acute cerebrovascular disease]
T2 - Minerva Med
TI - [Atrio-ventricular and intra-ventricular conduction disorders in a case of
acute cerebrovascular disease]
VL - 66
ID - 2896
ER -
TY - JOUR
AB - Brain stimulation can provoke a variety of arrhythmias and lower the
ventricular vulnerable threshold. In the animal with acute myocardial ischemia such
stimuli suffice to provoke ventricular fibrillation. Vagal neural traffic or
adrenal catecholamines are not the conduits for this brain-heart linkage.
Accompanying increases in heart rate or blood pressure are not prerequisites for
the changes in cardiac excitability. Increased sympathetic activity, whether
induced by neural or neurohumoral action, predisposes the heart to ventricular
fibrillation. Protection can be achieved with surgical and pharmacologic
denervation or reflex reduction in sympathetic tone. With acute myocardial
ischemia, augmented sympathetic activity accounts for the early surge of ectopic
activity frequently precipitating ventricular fibrillation. Asymmetries in
sympathetic neural discharge may also contribute to the genesis of serious
arrhythmias. The vagus nerve, through its muscarinic action, exerts an indirect
effect on cardiac vulnerability, the consequence of annulment of concomitant
adrenergic influence, rather than of any direct cholinergic action on the
ventricles. There exist anatomic, physiologic as well as molecular bases for such
interactions. Available experimental evidence indicates that environmental stresses
of diverse types can injure the heart, lower the threshold of cardiac vulnerability
to ventricular fibrillation and, in the animal with coronary occlusion, provoke
potentially malignant ventricular arrhythmias. Available evidence indicates that in
man, as in the experimental animal, administration of catecholamines can induce
ventricular arrhythmia, whereas vagal activity exerts an opposite effect.
Furthermore, in certain subjects diverse stresses and various psychologic states
provoke ventricular ectopic activity.
AN - 860697
AU - Lown, B.
AU - Verrier, R. L.
AU - Rabinowitz, S. H.
DA - May 26
DO - 10.1016/s0002-9149(77)80044-1
DP - NLM
ET - 1977/05/26
IS - 6
KW - Animals
Arrhythmias, Cardiac/etiology/physiopathology
Brain/physiology
Catecholamines/physiology
Coronary Disease/physiopathology
Electric Stimulation
Heart Diseases/complications/*mortality
Humans
Nervous System/*physiopathology
Stress, Psychological/*physiology
Sympathectomy
Sympathetic Nervous System/physiology/physiopathology
Vagus Nerve/physiology
Ventricular Fibrillation/etiology/physiopathology/prevention & control
LA - eng
N1 - Lown, B
Verrier, R L
Rabinowitz, S H
Journal Article
United States
Am J Cardiol. 1977 May 26;39(6):890-902. doi: 10.1016/s0002-9149(77)80044-1.
PY - 1977
SN - 0002-9149 (Print)
0002-9149
SP - 890-902
ST - Neural and psychologic mechanisms and the problem of sudden cardiac death
T2 - Am J Cardiol
TI - Neural and psychologic mechanisms and the problem of sudden cardiac death
VL - 39
ID - 2457
ER -
TY - JOUR
AB - BACKGROUND: Closure of the left atrial appendage (LAA) to prevent
cardioembolic events is an alternative therapy to oral anticoagulation in patients
with non-valvular atrial fibrillation. The LAA is an important source of
natriuretic peptides and its exclusion from the circulation may alter the blood
level of these hormones, thereby influencing their diagnostic value and clinical
effects. METHODS: We aimed to prospectively assess potential changes in mid-
regional pro A-type natriuretic peptide (MR-proANP) and N-terminal pro B-type
natriuretic peptide (NT-proBNP) levels 6 weeks and 6 months after interventional
LAA closure using the WATCHMAN device. RESULTS: In 29 consecutive patients with
successful LAA closure baseline MR-proANP level was 274±208pmol/l and decreased by
-24.5±68 (p=0.07) and -15.0±44pmol/l (p=0.10) after 6 weeks and 6 months,
respectively. The drop in the MR-proANP level after 6 weeks and 6 months was
significant in patients with elevated (≥214pmol/l) baseline MR-proANP level (n=15:
-54.3±78.0, p<0.01 and -31.8±45.4pmol/l, p=0.03, respectively) and those with
reduced left ventricular ejection fraction (LVEF<45%, n=7: -87.4±97.3, p=0.02 and
-60.3±42.6pmol/l, p=0.01, respectively). Baseline NT-proBNP level (median
1054pg/ml; IQR 621-1977pg/ml), sodium, potassium, mean systolic or diastolic blood
pressure did not change significantly in the mentioned patient groups. CONCLUSIONS:
After LAA closure, MR-proANP level decreased significantly in patients with
elevated baseline MR-proANP level or reduced LVEF, whereas NT-proBNP level remained
unchanged, thereby altering the correlation coefficient between the two biomarkers.
Our findings should be considered when using these biomarkers for diagnostic or
prognostic evaluation in patients with interventional LAA closure.
AD - Department of Internal Medicine, Division of Cardiology and Angiology,
Magdeburg University, Magdeburg, Germany. Electronic address:
blerim.luani@med.ovgu.de.
Department of Internal Medicine, Division of Cardiology and Angiology, Magdeburg
University, Magdeburg, Germany.
Institute of Clinical Chemistry and Pathobiochemistry, Magdeburg University,
Magdeburg, Germany.
AN - 28818408
AU - Luani, B.
AU - Rauwolf, T.
AU - Groscheck, T.
AU - Tanev, I.
AU - Herold, J.
AU - Isermann, B.
AU - Schmeisser, A.
AU - Braun-Dullaeus, R. C.
DA - Jul
DO - 10.1016/j.hlc.2017.07.001
DP - NLM
ET - 2017/08/19
IS - 7
J2 - Heart, lung & circulation
KW - Aged
Atrial Fibrillation/*blood/complications/surgery
Atrial Natriuretic Factor/*blood
Biomarkers/blood
Electrocardiography
Female
Follow-Up Studies
Humans
Male
Prognosis
Prospective Studies
Protein Precursors
LAA closure
MR proANP
NT proBNP
Natriuretic peptides
WATCHMAN device
LA - eng
N1 - 1444-2892
Luani, Blerim
Rauwolf, Thomas
Groscheck, Thomas
Tanev, Ivan
Herold, Joerg
Isermann, Berend
Schmeisser, Alexander
Braun-Dullaeus, Rüdiger C
Journal Article
Australia
Heart Lung Circ. 2018 Jul;27(7):828-834. doi: 10.1016/j.hlc.2017.07.001. Epub 2017
Aug 1.
PY - 2018
SN - 1443-9506
SP - 828-834
ST - Serial Assessment of Natriuretic Peptides in Patients Undergoing
Interventional Closure of the Left Atrial Appendage
T2 - Heart Lung Circ
TI - Serial Assessment of Natriuretic Peptides in Patients Undergoing
Interventional Closure of the Left Atrial Appendage
VL - 27
ID - 2427
ER -
TY - JOUR
AN - 11893830
AU - Lui, C. Y.
AU - Marcus, F. I.
AU - Sobonya, R. E.
DO - 10.1159/000047419
DP - NLM
ET - 2002/03/15
IS - 1
J2 - Cardiology
KW - Adult
Arrhythmogenic Right Ventricular Dysplasia/*diagnosis/*surgery
Atrial Flutter/*diagnosis
Cardiomyopathies/*diagnosis
Female
Heart Block/*diagnosis
*Heart Transplantation
Humans
Intracranial Embolism/*diagnosis
*Postpartum Period
Stroke/*diagnosis
LA - eng
N1 - Lui, Charles Y
Marcus, Frank I
Sobonya, Richard E
Case Reports
Letter
Switzerland
Cardiology. 2002;97(1):49-50. doi: 10.1159/000047419.
PY - 2002
SN - 0008-6312 (Print)
0008-6312
SP - 49-50
ST - Arrhythmogenic right ventricular dysplasia masquerading as peripartum
cardiomyopathy with atrial flutter, advanced atrioventricular block and embolic
stroke
T2 - Cardiology
TI - Arrhythmogenic right ventricular dysplasia masquerading as peripartum
cardiomyopathy with atrial flutter, advanced atrioventricular block and embolic
stroke
VL - 97
ID - 2754
ER -
TY - JOUR
AB - OBJECTIVE: Current knowledge on off-pump coronary artery bypass (OPCAB)
generally stems from single surgeons' experience or from series where OPCABs
constituted a minor fraction of coronary operations. The present center decided to
venture as far into OPCAB as possible during 1999. The present series thus
represents the average surgeon's experience. METHODS: During 1999, 533 patients
underwent coronary artery bypass grafting using cardiopulmonary bypass (CPB) in 368
and OPCAB in 165 including the circumflex artery (CX) area in 91. Coronary
arteriography was performed before discharge in the first 103 OPCAB patients.
RESULTS: The CPB and OPCAB groups differed as regards left ventricular ejection
fraction (53+/-13 versus 57+/-11, P < 0.0001) and frequency of triple-vessel or
left main stem disease (84 versus 32%, P < 0.0001) but were comparable as regards
diabetes (12%), prior myocardial infarct (57%), unstable angina (21%), and previous
heart surgery (3%). Using multivariate analyses, 30-day mortality (1.3%), P-
creatine kinase myocardial band (CKMB) > 80 microg/l (11.1%), re-sternotomy for
bleeding (4.5%) or dehiscense (1.7%), transitory cerebral ischemia and stroke
(1.7%), supraventricular tachycardia (27.4%), and hospital stay (mean 8 days) were
unrelated to off- versus on-pump surgery as well as to OPCAB in triple-vessel
disease. CX branches < or = 1mm, > or = 5 distal anastomoses, prior heart surgery,
right coronary artery (RCA) branches < or = 1.5mm, 8-21 days old myocardial
infarct, female gender, and preoperative acute arrhythmia (among others) were
identified as independent risk factors for mortality or increased CKMB in all 533
patients. The latter five risk factors were reproduced in the OPCAB group isolated.
The patency in the 103 OPCABs was 95.3, 91.8, and 85.3% in the left anterior
descending artery (LAD), CX, and RCA, respectively. Patency was inversely related
to diameter of the grafted vessel in the LAD and CX areas, unlike the RCA area.
CONCLUSIONS: The results after beating heart surgery were good also in patients
with triple-vessel disease, but specific gains relative to on-pump surgery could
not be shown. The independent risk factors in the OPCAB group may indicate relative
contraindications for OPCAB grafting.
AD - Department of Cardio-thoracic Surgery, Copenhagen University Hospital in
Gentofte, Copenhagen, Denmark. olelund@btopenworld.com
AN - 11675172
AU - Lund, O.
AU - Christensen, J.
AU - Holme, S.
AU - Fruergaard, K.
AU - Olesen, A.
AU - Kassis, E.
AU - Abildgaard, U.
DA - Nov
DO - 10.1016/s1010-7940(01)00972-1
DP - NLM
ET - 2001/10/25
IS - 5
KW - Adult
Aged
Aged, 80 and over
Coronary Artery Bypass/*methods/mortality
Coronary Vessels/pathology
Creatine Kinase/blood
Female
*Graft Occlusion, Vascular
Humans
Male
Middle Aged
Risk Factors
Stroke Volume
LA - eng
N1 - Lund, O
Christensen, J
Holme, S
Fruergaard, K
Olesen, A
Kassis, E
Abildgaard, U
Comparative Study
Journal Article
Germany
Eur J Cardiothorac Surg. 2001 Nov;20(5):901-7. doi: 10.1016/s1010-7940(01)00972-1.
PY - 2001
SN - 1010-7940 (Print)
1010-7940
SP - 901-7
ST - On-pump versus off-pump coronary artery bypass: independent risk factors and
off-pump graft patency
TI - On-pump versus off-pump coronary artery bypass: independent risk factors and
off-pump graft patency
VL - 20
ID - 3124
ER -
TY - JOUR
AB - The autosomal-recessive disorder Friedreich's ataxia is characterized by
progressive ataxia, often in association with cardiomyopathy. The most frequent
cause of death is cardiac dysfunction, reflecting congestive heart failure,
ventricular arrhythmias and cardio-embolic stroke. With the discovery of the
underlying genetic mutation, a variety of novel therapies are now progressing into
clinical trials. Consequently, it is crucial to understand the features of
cardiomyopathy in this disease and how new treatments may improve cardiac function.
The present artcle reviews the molecular basis of the disease, the clinical
features of cardiomyopathy in Friedreich's ataxia and the upcoming therapies.
AD - Department of Neurology, Children's Hospital of Philadelphia, Abramson
Research Center, 3615 Civic Center Boulevard, CHOP, Philadelphia, PA 19104, USA.
lynchd@mail.med.upenn.edu
AN - 22894632
AU - Lynch, D. R.
AU - Regner, S. R.
AU - Schadt, K. A.
AU - Friedman, L. S.
AU - Lin, K. Y.
AU - St John Sutton, M. G.
DA - Jun
DO - 10.1586/erc.12.57
DP - NLM
ET - 2012/08/17
IS - 6
KW - Animals
Arrhythmias, Cardiac/etiology/therapy
Cardiomyopathies/*etiology/physiopathology/therapy
Disease Progression
Friedreich Ataxia/genetics/*physiopathology/therapy
Heart Failure/etiology/therapy
Humans
Mutation
Stroke/etiology/therapy
LA - eng
N1 - 1744-8344
Lynch, David R
Regner, Sean R
Schadt, Kimberly A
Friedman, Lisa S
Lin, Kimberly Y
St John Sutton, Martin G
Journal Article
Review
England
Expert Rev Cardiovasc Ther. 2012 Jun;10(6):767-77. doi: 10.1586/erc.12.57.
PY - 2012
SN - 1477-9072
SP - 767-77
ST - Management and therapy for cardiomyopathy in Friedreich's ataxia
TI - Management and therapy for cardiomyopathy in Friedreich's ataxia
VL - 10
ID - 2426
ER -
TY - JOUR
AD - Department of Cardiology, Henan Provincial People's Hospital, 7-Weiwu Avenue,
Zhengzhou, China. Electronic address: mjf2000688@163.com.
Department of Cardiology, Henan Provincial People's Hospital, 7-Weiwu Avenue,
Zhengzhou, China.
AN - 27394981
AU - Ma, J. F.
AU - Fu, H. X.
DA - Oct 1
DO - 10.1016/j.ijcard.2016.06.282
DP - NLM
ET - 2016/07/11
KW - Adult
Cardiomyopathy, Hypertrophic/complications/*diagnostic imaging/physiopathology
Cerebral Hemorrhage/complications/*diagnostic imaging/physiopathology
Cerebral Infarction/complications/*diagnostic imaging/physiopathology
Heart Aneurysm/complications/*diagnostic imaging/physiopathology
Humans
Male
Tachycardia, Ventricular/complications/*diagnostic imaging/physiopathology
Thrombosis/complications/*diagnostic imaging/physiopathology
Aneurysm
Cerebral hemorrhagic infarction
Dabigatran
Mid-ventricular hypertrophic cardiomyopathy
Thrombus
LA - eng
N1 - 1874-1754
Ma, Ji-Fang
Fu, Hai-Xia
Case Reports
Editorial
Netherlands
Int J Cardiol. 2016 Oct 1;220:828-32. doi: 10.1016/j.ijcard.2016.06.282. Epub 2016
Jun 29.
PY - 2016
SN - 0167-5273
SP - 828-32
ST - Apical aneurysm, apical thrombus, ventricular tachycardia and cerebral
hemorrhagic infarction in a patient of mid-ventricular non-obstructive hypertrophic
cardiomyopathy: A case report
T2 - Int J Cardiol
TI - Apical aneurysm, apical thrombus, ventricular tachycardia and cerebral
hemorrhagic infarction in a patient of mid-ventricular non-obstructive hypertrophic
cardiomyopathy: A case report
VL - 220
ID - 2449
ER -
TY - JOUR
AB - BACKGROUND: Although atrial fibrillation (AF) is the most common abnormal
heart rhythm in men and women, there are gender differences. Mortality for women
with AF can be 2.5 times greater than for men. AF risk among women is also greater
than in men when patients have additional conditions. Women are more likely to
experience longer symptomatic episodes, more recurrences, and higher ventricular
rates during AF. We sought to explore presentation, comorbidities, treatment, and
quality-of-life issues among women with AF. METHODS: A convenience sample of 332
women with AF completed a 58-item online survey fielded for 2 weeks in April 2015.
RESULTS: Of the respondents, 94% were Caucasian; 76% consumed four or fewer
servings of fruits or vegetables per day; 43% engaged in moderate physical activity
for 10 minutes 3 or fewer days per week; 41% had a body mass index (BMI) of greater
than 30 kg/m(2); and 85% had never attended an AF support group. Women with AF
often juggle many health conditions. Almost none had participated in an AF clinical
trial. The ability to complete activities of daily living was associated
significantly and positively with fruit/vegetable consumption and physical activity
and significantly and negatively associated with BMI. Self-efficacy was associated
significantly with physical activity and support group attendance. Open-ended
comments showed many women patients have outstanding questions about their AF.
CONCLUSIONS: AF education resources should underscore the positive physical and
mental health effects of increasing fruit/vegetable consumption and physical
activity. Caregivers, clinicians, and women with AF need to be made aware of the
benefits of support groups, whether in-person or online, and clinical trials.
Future research should engage in effective recruitment of non-White women with AF.
AD - IQ Solutions, Inc., Rockville, Maryland. Electronic address:
EMacario@IQSolutions.com.
IQ Solutions, Inc., Rockville, Maryland.
WomenHeart: The National Coalition for Women with Heart Disease, Washington, DC.
Rush College of Medicine, Chicago, Illinois.
AN - 27094912
AU - Macario, E.
AU - Schneider, Y. T.
AU - Campbell, S. M.
AU - Volgman, A. S.
DA - May-Jun
DO - 10.1016/j.whi.2016.03.007
DP - NLM
ET - 2016/04/21
IS - 3
J2 - Women's health issues : official publication of the Jacobs Institute of
Women's Health
KW - Activities of Daily Living
Adolescent
Adult
Aged
Atrial Fibrillation/complications/*psychology
*Exercise
Female
*Health Knowledge, Attitudes, Practice
Health Status
Health Surveys
Humans
Middle Aged
*Quality of Life
Self Efficacy
*Social Support
Stroke/etiology
Treatment Outcome
Young Adult
LA - eng
N1 - 1878-4321
Macario, Everly
Schneider, Yukari T
Campbell, Susan M
Volgman, Annabelle Santos
Journal Article
United States
Womens Health Issues. 2016 May-Jun;26(3):288-97. doi: 10.1016/j.whi.2016.03.007.
Epub 2016 Apr 16.
PY - 2016
SN - 1049-3867
SP - 288-97
ST - Quality of Life Experiences among Women with Atrial Fibrillation: Findings
from an Online Survey
T2 - Womens Health Issues
TI - Quality of Life Experiences among Women with Atrial Fibrillation: Findings
from an Online Survey
VL - 26
ID - 2575
ER -
TY - JOUR
AB - Left atrial appendage (LAA) occlusion is increasingly accepted to reduce the
risk of stroke in patients with atrial arrhythmia who are unsuitable for routine
anticoagulation. It is generally performed under general anesthesia, guided by
transoesophageal echocardiography with accurate imaging being essential for correct
deployment of the device. We present a case where LAA occlusion was done under
local anesthesia in a high-anesthetic risk patient, using novel placement of an
intracardiac echo probe via a Mullins sheath in the right ventricular outflow tract
and pulmonary artery. This allowed accurate visualization of device deployment in
the LAA. This technique may increase the spectrum of patients who may benefit from
the procedure and decrease procedure time, fluoroscopy, and procedure-related
morbidity.
AD - Department of Cardiology, John Radcliffe Hospital, Headley Way, Oxford,
United Kingdom.
AN - 20517996
AU - MacDonald, S. T.
AU - Newton, J. D.
AU - Ormerod, O. J.
DA - Jan 1
DO - 10.1002/ccd.22652
DP - NLM
ET - 2010/06/03
IS - 1
KW - Aged
*Anesthesia, Local
Atrial Fibrillation/complications/diagnostic imaging/*surgery
Female
Humans
Treatment Outcome
Ultrasonography, Interventional/*methods
LA - eng
N1 - 1522-726x
MacDonald, Simon T
Newton, James D
Ormerod, Oliver J
Case Reports
Journal Article
United States
Catheter Cardiovasc Interv. 2011 Jan 1;77(1):124-7. doi: 10.1002/ccd.22652.
PY - 2011
SN - 1522-1946
SP - 124-7
ST - Intracardiac echocardiography off piste? Closure of the left atrial appendage
using ICE and local anesthesia
TI - Intracardiac echocardiography off piste? Closure of the left atrial appendage
using ICE and local anesthesia
VL - 77
ID - 2758
ER -
TY - JOUR
AB - AIMS: Implantable defibrillators (ICDs) successfully terminate ventricular
arrhythmias in hypertrophic cardiomyopathy (HCM), protect against bradycardia, and
monitor atrial arrhythmias. This may alter the natural history and causes of death.
METHODS: This nationwide observational longitudinal retrospective study of all HCM
patients implanted during 1995-2012 obtained data from the Swedish ICD Registry,
the National Patient Register, the Cause of Death Register, and were validated by
review of medical records. RESULTS: Of 342 patients (mean age 51.8 years, 70.8%
males), 45 died during a total follow-up of 1847 years (mean 5.4 years). Mean age
at death was 68.2 years (range 21-83 years; 12 were ≥75 years). Mean follow-up time
among the deceased was 4.9 years (quartiles 1.4-7.4 years). All-cause mortality was
higher in HCM patients compared with the age and sex-matched Swedish general
population (standardized mortality ratio 3.4; 95% confidence interval 2.4-4.5; P <
0.001). Main cause of death was heart failure (n = 27), stroke (n = 5), cancer (n
= 3), myocardial infarction (n = 2), sepsis (n = 2), and others (n = 4). Two
patients died suddenly, one after the ICD was turned off because of inappropriate
shocks, and one patient whose device system was removed after infection. HCM was
the main cause of death in 76% of the cases, mainly because of progressive heart
failure. CONCLUSION: For HCM patients, ICDs almost eliminate premature arrhythmic
death and result in a shift to heart failure as the cause of death in the majority
of cases. Still, mortality in HCM patients remains elevated and management of heart
failure and comorbidities must be improved to increase survival.
AD - aDepartment of Medicine, Cardiology Research Unit, Karolinska Institutet,
Stockholm bCentre for Research and Development, Uppsala University/Region
Gävleborg, Gävle cHeart Center and Department of Public Health and Clinical
Medicine, Umeå University, Umeå, Sweden.
AN - 26808417
AU - Magnusson, P.
AU - Gadler, F.
AU - Liv, P.
AU - Mörner, S.
DA - Jul
DO - 10.2459/jcm.0000000000000359
DP - NLM
ET - 2016/01/26
IS - 7
J2 - Journal of cardiovascular medicine (Hagerstown, Md.)
KW - Adult
Age Factors
Aged
Aged, 80 and over
Arrhythmias, Cardiac/*therapy
Cardiomyopathy, Hypertrophic/*complications/*mortality
Cause of Death
Comorbidity
Female
Humans
Male
Middle Aged
Registries
Risk Assessment
Stroke/mortality
Sweden
Young Adult
LA - eng
N1 - 1558-2035
Magnusson, Peter
Gadler, Fredrik
Liv, Per
Mörner, Stellan
Journal Article
Observational Study
United States
J Cardiovasc Med (Hagerstown). 2016 Jul;17(7):478-84. doi:
10.2459/JCM.0000000000000359.
PY - 2016
SN - 1558-2027
SP - 478-84
ST - Causes of death and mortality in hypertrophic cardiomyopathy patients with
implantable defibrillators in Sweden
T2 - J Cardiovasc Med (Hagerstown)
TI - Causes of death and mortality in hypertrophic cardiomyopathy patients with
implantable defibrillators in Sweden
VL - 17
ID - 2497
ER -
TY - JOUR
AB - BACKGROUND: Congestive heart failure in sinus rhythm ranks second after
atrial fibrillation (AF) among cardiogenic risk-factors for stroke. Clinical and
echocardiographic predictors of stroke in this high-risk population remain poorly
defined. METHODS: Retrospective screening of 1886 consecutive patients with severe
systolic dysfunction (LVEF ≤35%) at a tertiary medical center echocardiography
database (Nov 2005-Sep 2008) identified 83 patients in sinus rhythm with
cardioembolic stroke. Patients with AF on follow-up, prosthetic valve, ventricular
arrhythmia and lack of consensus between reviewing neurologists were excluded
(n=10). Consecutive age and gender-matched controls in sinus rhythm formed GpII
(n=73). RESULTS: The incidence of stroke was 3.9% (73/1886) over 35 months in this
study. There were no significant differences in prevalence of established clinical
risk-factors for stroke. There was a significantly higher prevalence of LV non-
compaction (p=0.02), aneurysm (p<0.01), spontaneous echo-contrast (p<0.01) and
pulmonary hypertension (p<0.001) in GpI. CONCLUSIONS: LV non-compaction, aneurysm,
spontaneous echo-contrast and pulmonary hypertension are associated with an
increased risk of stroke. While anticoagulation of these high-risk subgroups
appears reasonable, further study in a prospective randomized clinical trial merits
consideration.
AN - 19520443
AU - Mahajan, N.
AU - Ganguly, J.
AU - Simegn, M.
AU - Bhattacharya, P.
AU - Shankar, L.
AU - Madhavan, R.
AU - Chaturvedi, S.
AU - Ramappa, P.
AU - Afonso, L.
DA - Nov 5
DO - 10.1016/j.ijcard.2009.05.039
DP - NLM
ET - 2009/06/13
IS - 1
KW - Aged
Female
Heart Failure/complications/diagnostic imaging
Humans
Male
Middle Aged
Stroke/*diagnostic imaging/etiology
*Systole/physiology
Ventricular Dysfunction, Left/complications/*diagnostic imaging
LA - eng
N1 - 1874-1754
Mahajan, Nitin
Ganguly, Joya
Simegn, Mengistu
Bhattacharya, Pratik
Shankar, Lakshmi
Madhavan, Ramesh
Chaturvedi, Seemant
Ramappa, Preeti
Afonso, Luis
Comparative Study
Letter
Netherlands
Int J Cardiol. 2010 Nov 5;145(1):87-9. doi: 10.1016/j.ijcard.2009.05.039. Epub 2009
Jun 10.
PY - 2010
SN - 0167-5273
SP - 87-9
ST - Predictors of stroke in patients with severe systolic dysfunction in sinus
rhythm: role of echocardiography
T2 - Int J Cardiol
TI - Predictors of stroke in patients with severe systolic dysfunction in sinus
rhythm: role of echocardiography
VL - 145
ID - 2813
ER -
TY - JOUR
AB - BACKGROUND: Sarcoidosis with cardiovascular involvement is critical and is
associated with morbidity and mortality of the affected patients, if not properly
managed. In this systematic review and meta-analysis, we aimed to review the
available literature to find the prevalence of cardiovascular comorbidities and
their association with sarcoidosis. METHODS: An electronic search was conducted
through nine databases for articles reporting cardiovascular comorbidities in
sarcoidosis patients. We assessed the quality of each included article using the
National Institute of Health quality assessment tool (NIH), while meta-analysis was
used to pool the results. RESULTS: Out of 2208 reports screened, we included 14
studies. The most common cardiovascular comorbidities were hypertension 28.8%,
heart failure 9.3% and non-specified arrhythmia 8.1%. There were significant
association between sarcoidosis and heart failure and hypertension rather than
controls (OR = 2.10, 95%CI (1.65 - 2.69), p < 0.01) and (OR = 1.27, 95%CI (1.02 -
1.59), p = 0.036), respectively. However, we found no association between
sarcoidosis and cerebrovascular disease, ischemic heart disease and ventricular
tachycardia (p > 0.05). CONCLUSION: Sarcoidosis is associated with certain types of
cardiovascular comorbidities. Timely diagnosis and aggressive management in this
population are needed to minimize the hazards associated with the disease.
AD - Faculty of Medicine, Minia University, Minia, Egypt.
Sulaiman Al Rajhi University, College of Medicine, Qassim, Saudi Arabia. Electronic
address: m-ahmod@live.com.
Faculty of Medicine, Mansoura University, Mansoura, Egypt; Neurosurgery Department,
El Sheikh Zayed Specialized Hospital, Giza, Egypt.
AN - 32234258
AU - Mahmoud, A. R.
AU - Dahy, A.
AU - Dibas, M.
AU - Abbas, A. S.
AU - Ghozy, S.
AU - El-Qushayri, A. E.
DA - Mar 29
DO - 10.1016/j.hrtlng.2020.03.013
DP - NLM
ET - 2020/04/03
J2 - Heart & lung : the journal of critical care
KW - Cardiovascular
Sarcoidosis
Systematic review
interests.
LA - eng
N1 - 1527-3288
Mahmoud, Abdalla Reda
Dahy, Abdullah
Dibas, Mahmoud
Abbas, Alzhraa Salah
Ghozy, Sherief
El-Qushayri, Amr Ehab
Journal Article
United States
Heart Lung. 2020 Mar 29:S0147-9563(20)30101-1. doi: 10.1016/j.hrtlng.2020.03.013.
PY - 2020
SN - 0147-9563
ST - Association between sarcoidosis and cardiovascular comorbidity: A systematic
review and meta-analysis
T2 - Heart Lung
TI - Association between sarcoidosis and cardiovascular comorbidity: A systematic
ID - 3129
ER -
TY - JOUR
AB - Since they were launched on the market in 1964, cardiovascular indications
for beta-blockers have been validated and accepted worldwide. Numerous studies and
meta-analysis have confirmed their benefits. They reduce mortality in post
infarction and acute coronary syndrome populations and also in people with stable
coronary heart disease. Moreover, heart failure with systolic left ventricular
dysfunction is a major indication for this therapeutic class, providing a 30%
decrease in mortality. In patients with permanent atrial fibrillation, beta-
blockers are recommended for rate control. In hypertension patients, first-line
drug treatment with beta-blockers is currently discussed. Indeed, several studies
have shown that patients randomized in the beta-blocker arms experienced more
coronary heart and cerebrovascular diseases than comparators. Their lesser effect
on central blood pressure decrease could partially explain those results.
Nevertheless, beta-blockers are still considered as first-line drugs for
hypertension in the French and European guidelines. Long-term comparative studies
focusing on central blood pressure are needed. Concerning the other indications for
beta-blockers in vascular diseases, their use perioperatively to reduce surgical
cardiovascular risk raised much hope, but the most recent results are disappointed
and even suggest possible higher mortality. Finally, except for patients with
critical ischemia of the lower limbs, presence of peripheral artery disease should
probably be considered as a condition favoring their prescription.
AD - Unité d'Hypertension Artérielle, Prévention et Thérapeutique
Cardiovasculaires, Centre de Diagnostic et de Thérapeutique, Université Paris-
Descartes, Hôtel-Dieu, AP-HP, place du Parvis-Notre-Dame, 75004 Paris, France.
AN - 22093805
AU - Mairesse, S.
AU - Blacher, J.
AU - Safar, M. E.
DA - Dec
DO - 10.1016/j.jmv.2011.10.001
DP - NLM
ET - 2011/11/19
IS - 6
J2 - Journal des maladies vasculaires
KW - Adrenergic beta-Antagonists/adverse effects/*therapeutic use
Aged
Atrial Fibrillation/drug therapy/mortality
Cardiovascular Diseases/*drug therapy/mortality
Contraindications
Coronary Disease/drug therapy/mortality
Female
Heart Failure
Humans
Male
Middle Aged
Perioperative Period
Risk Factors
Ventricular Dysfunction, Left/drug therapy/mortality
LA - fre
N1 - 2214-8116
Mairesse, S
Blacher, J
Safar, M-E
Journal Article
Review
France
J Mal Vasc. 2011 Dec;36(6):339-47. doi: 10.1016/j.jmv.2011.10.001. Epub 2011 Nov
16.
OP - Mise au point sur les bêtabloquants pour les médecins vasculaires en 2012.
PY - 2011
SN - 0398-0499
SP - 339-47
ST - [Focus on beta-blockers for vascular specialists in 2012]
T2 - J Mal Vasc
TI - [Focus on beta-blockers for vascular specialists in 2012]
VL - 36
ID - 3019
ER -
TY - JOUR
AB - BACKGROUND: Acute cerebral events play an important role in generating
autonomic imbalance especially cardiac rhythm disturbances. This forms the basis of
significant lethal abnormalities of heart rate and rhythm like QTc prolongation,
ventricular fibrillation, asystole, and ultimately death. This study was conducted
to determine the frequency of QTc prolongation in patients presenting with acute
haemorrhagic stroke at a tertiary care hospital. METHODS: This descriptive case
series was conducted at Medical Unit-I, ward-5, Jinnah Postgraduate Medical Centre
(JPMC), Karachi, from 13 October, 2009 to 12 April, 2010. Patients of either gender
and age > 18 years who presented within 48 hours of onset of acute hemorrhagic
stroke for the first time, confirmed by computerized tomography (CT) scan of brain
were included. A 12 lead electrocardiogram (ECG) was performed. Lead III and VI
were used for this due to their importance in this aspect. QTc was then calculated
by using Bazetts formula. Data was analysed using SPSS-12. RESULTS: Among 95
patients of acute haemorrhagic stroke, 48 (50.5%) had prolonged QTc in lead III, 47
(49.5%) had prolonged QTc in lead VI. The average QTc interval in lead III was
440.4 +/- 45.2 (Range = 364-571). Proportion of prolonged QTc in lead III was
higher in males than females. Frequency of QTc III prolongation was higher in
comparatively younger age groups than older age groups. CONCLUSION: The frequency
of prolonged QTc interval among patients of acute hemorrhagic stroke is alarmingly
higher in our setup. Prolonged QTc is a useful predictor of impending clinical
deterioration and provide an opportunity for early intervention to reduce severe
loss like mortality.
AN - 25226747
AU - Malik, S.
AU - Abdul Sattar, R.
AU - Shah, S.
AU - Rehman, H.
AU - Tahira
AU - Ismail, M. A.
DA - Jul-Dec
DP - NLM
ET - 2013/07/01
IS - 3-4
J2 - Journal of Ayub Medical College, Abbottabad : JAMC
KW - Adult
Aged
Aged, 80 and over
Electrocardiography
Female
Humans
Long QT Syndrome/*complications/*epidemiology
Male
Middle Aged
Stroke/*complications/*epidemiology/physiopathology
LA - eng
N1 - Malik, Sarwar
Abdul Sattar, Rukhsana
Shah, Shahnaz
Rehman, Hisala
Tahira
Ismail, Muhammad Ali
Journal Article
Pakistan
J Ayub Med Coll Abbottabad. 2013 Jul-Dec;25(3-4):75-7.
PY - 2013
SN - 1025-9589 (Print)
1025-9589
SP - 75-7
ST - Frequency of QTc prolongation in patients with hemorrhagic stroke
T2 - J Ayub Med Coll Abbottabad
TI - Frequency of QTc prolongation in patients with hemorrhagic stroke
VL - 25
ID - 2630
ER -
TY - JOUR
AB - The HeartWare Ventricular Assist System (HVAD) provides significant
improvements in survival and quality of life, and here, we seek to evaluate
temporal differences in the adverse event (AE) rates. Patients (n = 382) in the
ADVANCE bridge-to-transplant and continued access protocol trial were assessed for
bleeding, cardiac arrhythmia, infection, ischemic and hemorrhagic stroke, and right
heart failure during predetermined time periods (≤30, >30-180, >180-365, >365-730,
>730-1,095 days) after HVAD implant. The Kaplan-Meier survival at 30 days, 6
months, 1, 2, and 3 years was 98%, 90%, 84%, 71%, and 63%, respectively. There were
significantly fewer total AEs in days >30-180 (events per patient year [EPPY] =
5.34) compared with the first 30 days post HVAD implantation (EPPY = 30.36; p <
0.0001). The total AE rate in days >180-365 (EPPY = 4.09) was also significantly
lower than the event rate in days >30-180 (EPPY = 5.34; p < 0.0001). Incidence of
cardiac arrhythmias, infections, strokes, and right heart failure were highest
immediately post implant and lower rates occurred after 6 months. After 1 year, all
AEs exhibited stable rates that were comparable up to 3 years of support (all p >
0.05). This changing risk over time has clinically meaningful implications toward
improving patient management.
AD - From the *Department of Cardiac Surgery, Mayo Clinic Rochester, Rochester,
MN; †Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI;
‡Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh,
PA; §Division of Cardiothoracic Surgery, University of Louisville, Louisville, KY;
¶MedStar Heart And Vascular Institute, MedStar Washington Hospital Center,
Washington, DC; ‖Cardiac and Thoracic Surgery, University of Chicago Medicine,
Chicago, IL; #Division of Cardiac Surgery, Northwestern University Feinberg School
of Medicine, Chicago, IL; **Heart Transplant & Ventricular Assist Device Program,
Loyola University Health System, Maywood, IL; and ††HeartWare Inc., Framingham, MA.
AN - 28475561
AU - Maltais, S.
AU - Aaronson, K. D.
AU - Teuteberg, J. J.
AU - Slaughter, M. S.
AU - Najjar, S. S.
AU - Jeevanandam, V.
AU - Pham, D. T.
AU - McGee, E. C., Jr.
AU - Leadley, K.
AU - Kormos, R. L.
DA - Nov/Dec
DO - 10.1097/mat.0000000000000585
DP - NLM
ET - 2017/05/06
IS - 6
KW - Heart Failure/epidemiology/mortality/therapy
Humans
Stroke/epidemiology
Time Factors
LA - eng
N1 - 1538-943x
Maltais, Simon
Aaronson, Keith D
Teuteberg, Jeffrey J
Slaughter, Mark S
Najjar, Samer S
Jeevanandam, Valluvan
Pham, Duc T
McGee, Edwin C Jr
Leadley, Katrin
Kormos, Robert L
Journal Article
United States
ASAIO J. 2017 Nov/Dec;63(6):745-751. doi: 10.1097/MAT.0000000000000585.
PY - 2017
SN - 1058-2916
SP - 745-751
ST - Adverse Event Rates Change Favorably Over Time for Patients Bridged With the
HeartWare Left Ventricular Assist Device
T2 - Asaio j
TI - Adverse Event Rates Change Favorably Over Time for Patients Bridged With the
HeartWare Left Ventricular Assist Device
VL - 63
ID - 2834
ER -
TY - JOUR
AB - Atrial fibrillation (AF) is intermittent in 30% of patients with
cardioembolic stroke and, therefore, might not be seen in a single standard ECG
recording. The aim of this study was to evaluate if prolonged ECG monitoring (96 h)
finds episodes of intermittent AF beyond the 24 h ECG monitoring in patients with
cryptogenic stroke or transient ischemic attack (TIA). We prospectively evaluated
consecutive patients affected by cryptogenic stroke or TIA who had sinus rhythm on
a 12-lead ECG on admission, and during ECG monitoring performed in the acute phase
(for at least 24 h). Patients had continuous 96 h Holter ECG monitoring within
30 days from stroke onset. 114 patients were included in the study (mean age
63.1 ± 15.1, 59 males). AF was found in 29 patients (24.3%). In 20 patients, AF was
found in the first 24 h of recording, and in nine patients after 24 h. In addition,
several other dysrhythmias such as supraventricular ectopic activity (33),
ventricular tachycardia (10), sinus pause (4) and sinus-atrial block (1) were
found. In patients with cryptogenic stroke or TIA, 96 h ECG monitoring detected a
high rate of AF. One-third of AF was seen beyond 24 h of ECG monitoring.
AD - Division of Internal and Cardiovascular Medicine, Stroke Unit, University of
Perugia, Perugia, Italy, giorgia.manina@yahoo.it.
AN - 22249917
AU - Manina, G.
AU - Agnelli, G.
AU - Becattini, C.
AU - Zingarini, G.
AU - Paciaroni, M.
DA - Feb
DO - 10.1007/s11739-012-0755-3
DP - NLM
ET - 2012/01/18
IS - 1
J2 - Internal and emergency medicine
KW - Aged
Atrial Fibrillation/*diagnosis/*epidemiology
Female
Humans
Ischemic Attack, Transient/*epidemiology
Male
Middle Aged
Prospective Studies
Risk Factors
LA - eng
N1 - 1970-9366
Manina, Giorgia
Agnelli, Giancarlo
Becattini, Cecilia
Zingarini, Gianluca
Paciaroni, Maurizio
Journal Article
Italy
Intern Emerg Med. 2014 Feb;9(1):65-7. doi: 10.1007/s11739-012-0755-3. Epub 2012 Jan
17.
PY - 2014
SN - 1828-0447
SP - 65-7
ST - 96 hours ECG monitoring for patients with ischemic cryptogenic stroke or
transient ischaemic attack
T2 - Intern Emerg Med
TI - 96 hours ECG monitoring for patients with ischemic cryptogenic stroke or
transient ischaemic attack
VL - 9
ID - 2394
ER -
TY - JOUR
AB - STUDY OBJECTIVES: Even in high-risk population groups, not all patients have
the same risk of sudden cardiac death (SCD). Given the emerging data about the
amino-terminal fragment of the brain natriuretic peptide prohormone (NT-proBNP)
value in heart failure, we planned to evaluate the importance of NT-proBNP levels
in predicting the occurrence of malignant arrhythmias in patients with ischemic
cardiomyopathy and implantable cardioverter-defibrillators (ICDs). DESIGN:
Prospective study. SETTING: Tertiary referral center. PATIENTS: Thirty five
ambulatory patients with previous myocardial infarction, left ventricular ejection
fraction < 35%, and ICDs for primary prevention of SCD according to Multicenter
Automatic Defibrillator Implantation Trial I criteria. INTERVENTIONS: Venous blood
samples for plasma NT-proBNP measurement were obtained after 30 min of supine rest
from all patients at the beginning of the study. Patients were evaluated every 2
months, or sooner in cases of device discharges, during a 1-year follow-up period.
Data concerning arrhythmias and device therapy were stored at the time of device
interrogation on each follow-up visit. MEASUREMENTS AND RESULTS: During 1-year
follow-up, 11 of 35 patients (31.4%) received 18 antiarrhythmic device therapies
for ventricular tachyarrhythmia (VT). Patients who experienced such arrhythmias had
NT-proBNP levels of 997.27 +/- 335.14 pmol/L (mean +/- SD), whereas those without
VT had NT-proBNP levels of 654.87 +/- 237.87 pmol/L (p = 0.001). An NT-proBNP
cutoff value of 880 pmol/L had a sensitivity of 73%, a specificity of 88%, a
positive predictive value of 80%, and a negative predictive value of 88% for the
prediction of occurrence-sustained VT events. CONCLUSION: To achieve the maximum
benefit by ICD therapy, more precise risk stratification is required, even in high-
risk, post-myocardial infarction patients. Plasma NT-proBNP levels comprise a
promising method that could help in the better identification of a patient group
with an even higher risk of sudden death.
AD - Department of Cardiology, University Hospital of Heraklion, 71000, Voutes,
Heraklion-Crete, Greece. mman@med.uoc.gr
AN - 16236931
AU - Manios, E. G.
AU - Kallergis, E. M.
AU - Kanoupakis, E. M.
AU - Mavrakis, H. E.
AU - Kambouraki, D. C.
AU - Arfanakis, D. A.
AU - Vardas, P. E.
DA - Oct
DO - 10.1378/chest.128.4.2604
DP - NLM
ET - 2005/10/21
IS - 4
J2 - Chest
KW - Adult
Aged
Biomarkers/blood
Cardiomyopathies/blood/*therapy
Female
Follow-Up Studies
Humans
Male
Middle Aged
Tachycardia, Ventricular/blood/epidemiology/*therapy
LA - eng
N1 - Manios, Emmanuel G
Kallergis, Eleftherios M
Kanoupakis, Emmanuel M
Mavrakis, Hercules E
Kambouraki, Despina C
Arfanakis, Dimitris A
Vardas, Panos E
Journal Article
United States
Chest. 2005 Oct;128(4):2604-10. doi: 10.1378/chest.128.4.2604.
PY - 2005
SN - 0012-3692 (Print)
0012-3692
SP - 2604-10
ST - Amino-terminal pro-brain natriuretic peptide predicts ventricular
arrhythmogenesis in patients with ischemic cardiomyopathy and implantable
cardioverter-defibrillators
T2 - Chest
TI - Amino-terminal pro-brain natriuretic peptide predicts ventricular
arrhythmogenesis in patients with ischemic cardiomyopathy and implantable
cardioverter-defibrillators
VL - 128
ID - 2945
ER -
TY - JOUR
AB - Growing evidence suggests that atrial fibrillation (AF), in addition to its
thromboembolic risk, is a risk factor for cognitive impairment (CI) via several
pathways and mechanisms, further contributing to morbidity/mortality. Prior stroke
is a contributor to CI, but AF is also associated with CI independently from prior
stroke. Silent brain infarctions, microemboli and microbleeds, brain atrophy,
cerebral hypoperfusion from widely fluctuating ventricular rates, altered
hemostatic function, vascular oxidative stress, and inflammation may all exacerbate
CI, particularly in patients with persistent/permanent rather than paroxysmal AF
and with increased duration/burden of the arrhythmia. Brain magnetic resonance
imaging is an important screening tool in eliciting and monitoring vascular and
nonvascular lesions contributing to CI. Evidence is also emerging about the role of
genetics in CI development. Anticoagulation and rhythm/rate control strategies may
protect against CI preventing or slowing its progression or conversion to dementia,
particularly at the early stages when CI may still be a treatable condition.
Importantly, AF and CI share many common risk factors. Thus, screening for these 2
conditions and searching for and managing modifiable risk factors and potentially
reversible causes for both AF and CI remains an important step toward prevention or
amelioration of the impact incurred by these 2 conditions.
AD - Red Cross Hospital, Athens, Greece.
Patras University School of Medicine, Patras, Greece.
Canterbury Christ Church University, Canterbury, United Kingdom.
Onassis Cardiac Surgery Center, Athens, Greece.
First and Third Department of Cardiology, Athens University School of Medicine,
Athens, Greece.
AN - 32233780
AU - Manolis, T. A.
AU - Manolis, A. A.
AU - Apostolopoulos, E. J.
AU - Melita, H.
AU - Manolis, A. S.
DA - Jul
DO - 10.1177/0003319720910669
DP - NLM
ET - 2020/04/03
IS - 6
J2 - Angiology
Atrial Fibrillation/diagnosis/drug therapy/*epidemiology/physiopathology
Brain/*drug effects/physiopathology
Clinical Decision-Making
*Cognition/drug effects
Cognitive Dysfunction/diagnosis/*epidemiology/physiopathology/prevention & control
Decision Support Techniques
Heart Conduction System/*drug effects/physiopathology
Humans
Prognosis
Risk Assessment
Risk Factors
Stroke/diagnosis/drug therapy/*epidemiology/physiopathology
*anticoagulation
*brain hypoperfusion
*cognitive function
*dementia
*magnetic resonance imaging
*silent cerebral infarcts
*stroke
LA - eng
N1 - 1940-1574
Manolis, Theodora A
Manolis, Antonis A
Apostolopoulos, Evdoxia J
Melita, Helen
Manolis, Antonis S
Orcid: 0000-0002-0336-4745
Journal Article
Review
United States
Angiology. 2020 Jul;71(6):498-519. doi: 10.1177/0003319720910669. Epub 2020 Apr 1.
PY - 2020
SN - 0003-3197
SP - 498-519
ST - Atrial Fibrillation and Cognitive Impairment: An Associated Burden or Burden
by Association?
T2 - Angiology
TI - Atrial Fibrillation and Cognitive Impairment: An Associated Burden or Burden
by Association?
VL - 71
ID - 2478
ER -
TY - JOUR
AB - PURPOSE: to assess rate of complications after transcatheter aortic valve
implantation (TAVI). MATERIAL AND RESULTS: Our study included 99 patients who
underwent TAVI. Frequent complications were: bleeding not requiring surgical
hemostasis (17.2%), hemopericardium (6%), novel cardiac rhythm disturbances
requiring permanent pacemaker implantation (15.1%), delirium in early postoperative
period (10.7%), acute kidney injury (8.0%), stroke (7%), ventricular fibrillation
(5.1%), myocardial infarction (2%). There were no significant differences in rate
and type of complications between transapical and transfemoral TAVI. Comparison of
general and local anesthesia showed that rate of ventricular fibrillation was
significantly higher among patients subjected to transfemoral TAVI under local
anesthesia (p less or equal 0.012).
AD - Russian Cardiology Research and Production Complex, Moscow, Russia.
AN - 28294747
AU - Margolina, A. A.
AU - Gruzdev, K. A.
AU - Lepilin, M. G.
AU - Tabakyan, E. A.
AU - Imaev, T. E.
AU - Akchurin, R. S.
DA - Feb
DO - 10.18565/cardio.2016.2.35-39
DP - NLM
ET - 2017/03/16
IS - 2
J2 - Kardiologiia
KW - Aged
Aged, 80 and over
Aortic Valve
Female
Heart Valve Prosthesis Implantation
Humans
Male
Myocardial Infarction/*etiology
Stroke/*etiology
Transcatheter Aortic Valve Replacement/*adverse effects
LA - rus
N1 - Margolina, A A
Gruzdev, K A
Lepilin, M G
Tabakyan, E A
Imaev, T E
Akchurin, R S
Journal Article
Russia (Federation)
Kardiologiia. 2016 Feb;56(2):35-39. doi: 10.18565/cardio.2016.2.35-39.
PY - 2016
SN - 0022-9040 (Print)
0022-9040
SP - 35-39
ST - [Complications After Transcatheter Aortic Valve Implantation]
T2 - Kardiologiia
TI - [Complications After Transcatheter Aortic Valve Implantation]
VL - 56
ID - 2467
ER -
TY - JOUR
AB - BACKGROUND: Hypertrophic cardiomyopathy (HCM) has been prominently associated
with adverse disease complications, including sudden death or heart failure death
and a generally adverse prognosis, with annual mortality rates of up to 6%.
OBJECTIVES: This study determined whether recent advances in management strategy,
including implantable cardioverter-defibrillators (ICDs), heart transplantation, or
other therapeutic measures have significantly improved survival and the clinical
course of adult HCM patients. METHODS: We addressed long-term outcomes in 1,000
consecutive adult HCM patients presenting at 30 to 59 years of age (mean 45±8
years) over 7.2±5.2 years of follow-up. RESULTS: Of 1,000 patients, 918 (92%)
survived to 53±9.2 years of age (range 32 to 80 years) with 91% experiencing no or
only mild symptoms at last evaluation. HCM-related death occurred in 40 patients
(4% [0.53%/year]) at 50±10 years from the following events: progressive heart
failure (n=17); arrhythmic sudden death (SD) (n=17); and embolic stroke (n=2). In
contrast, 56 other high-risk patients (5.6%) survived life-threatening events, most
commonly with ICD interventions for ventricular tachyarrhythmias (n=33) or heart
transplantation for advanced heart failure (n=18 [0.79%/year]). SD occurred in
patients who declined ICD recommendations, had evaluations before application of
prophylactic ICDs to HCM, or were without conventional risk factors. The 5- and 10-
year survival rates (confined to HCM deaths) were 98% and 94%, respectively, not
different from the expected all-cause mortality in the general U.S. population
(p=0.25). Multivariate independent predictors of adverse outcome were younger age
at diagnosis, female sex, and increased left atrial dimension. CONCLUSIONS: In a
large longitudinally assessed adult HCM cohort, we have demonstrated that
contemporary management strategies and treatment interventions, including ICDs for
SD prevention, have significantly altered the clinical course, now resulting in a
low disease-related mortality rate of 0.5%/year and an opportunity for extended
longevity.
AD - Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation,
Minneapolis, Minnesota. Electronic address: hcm.maron@mhif.org.
Hypertrophic Cardiomyopathy Center, Tufts Medical Center, Boston, Massachusetts.
Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation,
Minneapolis, Minnesota.
AN - 25953744
AU - Maron, B. J.
AU - Rowin, E. J.
AU - Casey, S. A.
AU - Link, M. S.
AU - Lesser, J. R.
AU - Chan, R. H.
AU - Garberich, R. F.
AU - Udelson, J. E.
AU - Maron, M. S.
DA - May 12
DO - 10.1016/j.jacc.2015.02.061
DP - NLM
ET - 2015/05/09
IS - 18
KW - Adult
Age Factors
Aged
Aged, 80 and over
Cardiomyopathy, Hypertrophic/*mortality/*therapy
Death, Sudden, Cardiac/epidemiology
Female
Humans
Male
Middle Aged
Sex Factors
Stroke/etiology
Tachycardia, Ventricular/prevention & control
heart failure
heart transplant
implantable defibrillators
sudden death
LA - eng
N1 - 1558-3597
Maron, Barry J
Rowin, Ethan J
Casey, Susan A
Link, Mark S
Lesser, John R
Chan, Raymond H M
Garberich, Ross F
Udelson, James E
Maron, Martin S
Journal Article
United States
J Am Coll Cardiol. 2015 May 12;65(18):1915-28. doi: 10.1016/j.jacc.2015.02.061.
PY - 2015
SN - 0735-1097
SP - 1915-28
ST - Hypertrophic Cardiomyopathy in Adulthood Associated With Low Cardiovascular
Mortality With Contemporary Management Strategies
TI - Hypertrophic Cardiomyopathy in Adulthood Associated With Low Cardiovascular
Mortality With Contemporary Management Strategies
VL - 65
ID - 2422
ER -
TY - JOUR
AB - Current knowledge concerning idiopathic prolapse of the mitral valve is
illustrated. The histopathological cause is myxoid degeneration of the mitral
cusps, which sometimes extends to the tendinous cords, the valve implant ring, and
the apex of the papillary muscles. Primary damage to these structures, whose
intactness is essential for correct closure of the ostium, causes protrusion of the
ventricular cusps into the left atrium during ventricular systole (i.e. prolapse).
The reason for this degeneration is not known. The high familial incidence of
prolapse lends credit to the most widely held suggestion, namely a hereditary
defect. The clinical progress is benign in the great majority of cases
("crystallized" form) and is often asymptomatic. Complications are possible,
however, and must always be borne in mind. They include progressive and acute
mitral insufficiency, infective endocarditis, arrhythmias, motor or sensitive
neurological complications, and sudden death. Particular attention must be paid to
the path to be followed to arrive at the correct diagnosis. Careful evaluation of
some of the clinical signs arousing suspicion in the previous history and/or
objective examination enable a diagnosis to be formed with relatively simple, non-
invasive instrumental techniques, such as echocardiography and polycardiography,
provided other forms of prolapse secondary to ischaemic heart disease, mitral
endocarditis, etc. are excluded. "Therapy is obviously necessary in the presence of
complications; however, even in "crystallized" form, in the presence of subjective
symptoms, tranquillizers and possibly beta-blockers may be necessary".
AN - 6139773
AU - Martelli, M.
AU - Barbato, G.
AU - Saponaro, A.
DA - Oct 27
DP - NLM
ET - 1983/10/27
IS - 41
J2 - Minerva medica
Digitalis Glycosides/therapeutic use
Endocarditis, Bacterial/etiology
Humans
Marfan Syndrome/diagnosis
*Mitral Valve Prolapse/diagnosis/drug therapy/genetics
Neurocirculatory Asthenia/diagnosis
Pericarditis/diagnosis
Rheumatic Heart Disease/diagnosis
LA - ita
N1 - Martelli, M
Barbato, G
Saponaro, A
English Abstract
Journal Article
Review
Italy
Minerva Med. 1983 Oct 27;74(41):2415-27.
OP - Il prolasso mitralico idiopatico.
PY - 1983
SN - 0026-4806 (Print)
0026-4806
SP - 2415-27
ST - [Idiopathic mitral valve prolapse]
T2 - Minerva Med
TI - [Idiopathic mitral valve prolapse]
VL - 74
ID - 2593
ER -
TY - JOUR
AB - OBJECTIVE: To determine whether in a larger data base call for sudden cardiac
death exhibits a specific circadian rhythm similar to that recently demonstrated by
Levine et al. DESIGN AND SETTING: The time of the day of calls received for out-of-
hospital cardiac arrests (OOHCA) prospectively registered between 1983 and '90 by 7
major Belgian pre-hospital EMS-MICU services. Chrono-biologic assessment was made
by two-harmonic linear regression analysis of the data tabulated by hour of the
day. The hourly distribution of calls for OOHCAs was subjected to Fourier
transformation resulting in a periodogram. PATIENTS: 3471 OOHCAs with presumed
cardiac etiology and age of more than 18 years versus 2007 inpatients registered in
the same period. MEASUREMENTS AND RESULTS: Significant and remarkably similar
circadian patterns were found (R-square = 0.84) for the cardiac origin OOHCAs and
the ventricular fibrillation OOHCAs. There is a low incidence during the night and
an increased incidence from 6 a.m. until noon with an additional early afternoon-
peak. The data were always better fitted when applying sinusoids with periods of 8
and 24 h instead of 12 and 24 h. Our observed circadian distribution resembles the
reported circadian variation of ischaemic episodes, ventricular tachycardia and
acute myocardial infarction in the awake hours. The time distribution of OOHCA
(cardiac origin) differs significantly from OOHCA (non-cardiac origin) and from in-
hospital cardiac arrests. The in-hospital CA pattern shows less deviation. The age
dependent variation in the incidence of cardiac origin OOHCAs, was not obvious for
the ventricular fibrillation subgroup. CONCLUSION: Knowledge about the cyclical
nature of incidence of cardiac arrests is useful to improve intersystem comparisons
and make sound decisions about prophylaxis, treatment and allocation of resources.
AN - 7560473
AU - Martens, P. R.
AU - Calle, P.
AU - Van den Poel, B.
AU - Lewi, P.
DA - Jan
DO - 10.1007/bf02425153
DP - NLM
ET - 1995/01/01
IS - 1
J2 - Intensive care medicine
KW - *Circadian Rhythm
Death, Sudden, Cardiac/*epidemiology/etiology
Emergency Medical Services/*statistics & numerical data
Fourier Analysis
Humans
Incidence
Inpatients
Linear Models
Outpatients
Prospective Studies
Time Factors
LA - eng
N1 - Martens, P R
Calle, P
Van den Poel, B
Lewi, P
Comparative Study
Journal Article
United States
Intensive Care Med. 1995 Jan;21(1):45-9. doi: 10.1007/BF02425153.
PY - 1995
SN - 0342-4642 (Print)
0342-4642
SP - 45-9
ST - Further prospective evidence of a circadian variation in the frequency of
call for sudden cardiac death. Belgian Cardiopulmonary Cerebral Resuscitation Study
Group
T2 - Intensive Care Med
TI - Further prospective evidence of a circadian variation in the frequency of
call for sudden cardiac death. Belgian Cardiopulmonary Cerebral Resuscitation Study
Group
VL - 21
ID - 3004
ER -
TY - JOUR
AB - Atrial septal defect (ASD) is a common congenital abnormality that occurs in
the form of ostium secundum, ostium primum, sinus venosus, and rarely, coronary
sinus defects. Pathophysiologic consequences of ASDs typically begin in adulthood,
and include arrhythmia, paradoxical embolism, cerebral abscess, pulmonary
hypertension, and right ventricular failure. Two-dimensional (2D) transthoracic
echocardiography with Doppler is a central aspect of the evaluation. This
noninvasive imaging modality often establishes the diagnosis and provides critical
information guiding intervention. A comprehensive echocardiogram includes
evaluation of anatomical ASD characteristics, flow direction, associated
abnormalities (eg, anomalous pulmonary veins), right ventricular anatomy and
function, pulmonary pressures, and the pulmonary/systemic flow ratio. The primary
indication for ASD closure is right heart volume overload, whether symptoms are
present or not. ASD closure may also be reasonable in other contexts, such as
paradoxical embolism. ASD type and local clinical expertise guide choice of a
percutaneous versus surgical approach to ASD closure.
Baltimore, Maryland, USA.
AN - 25861226
AU - Martin, S. S.
AU - Shapiro, E. P.
AU - Mukherjee, M.
C2 - PMC4373719
DO - 10.4137/cmc.S15715
DP - NLM
ET - 2014/01/01
IS - Suppl 1
J2 - Clinical Medicine Insights. Cardiology
KW - atrial septal defect
coronary sinus defect
echocardiography
ostium primum defect
ostium secundum defect
sinus venosus defect
LA - eng
N1 - 1179-5468
Martin, Seth S
Shapiro, Edward P
Mukherjee, Monica
Journal Article
Review
Clin Med Insights Cardiol. 2015 Mar 23;8(Suppl 1):93-8. doi: 10.4137/CMC.S15715.
eCollection 2014.
PY - 2014
SN - 1179-5468 (Print)
1179-5468
SP - 93-8
ST - Atrial septal defects - clinical manifestations, echo assessment, and
intervention
T2 - Clin Med Insights Cardiol
TI - Atrial septal defects - clinical manifestations, echo assessment, and
intervention
VL - 8
ID - 3082
ER -
TY - JOUR
AB - The authors examined 180 patients where disorders of cerebral circulation
developed on the background of different disturbance of the heart rhythm. The
patients suffered from rheumatic heart disease, hypertensive disease or
atherosclerosis in concomitance with ischemic heart disease. For comparison, 100
patients with similar disorders were studied, but without disturbances of heart
rhythm. It was established that disorders of cerebral circulation were more
frequently seen in permanent forms of cardiac fibrillation and less so in
paroxysmal cardiac fibrillation and extrasystoles. The most severe disorders of
cerebral circulation were seen in combinations of permanent forms of cardiac
fibrillation with single and frequent ventricular extrasystoles in patients with
rheumatic heart disease.
AN - 65883
AU - Martynov Iu, S.
AU - Burdov, A. A.
AU - Pushkar' Iu, T.
AU - Il'ina, L. I.
DP - NLM
ET - 1977/01/01
IS - 1
J2 - Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia :
1952)
KW - Adult
Cardiac Complexes, Premature/complications
Cerebrovascular Disorders/*complications
Female
Humans
Hypertension/*complications
Male
Middle Aged
Rheology
LA - rus
N1 - Martynov, Iu S
Burdov, A A
Pushkar', Iu T
Il'ina, L I
English Abstract
Journal Article
Russia (Federation)
Zh Nevropatol Psikhiatr Im S S Korsakova. 1977;77(1):3-11.
OP - Rasstroistva mozgovogo krovoobrashcheniia u bol'nykh s serdechno-sosudistymi
zabolevaniiami, soprovozhdaiushcimisia narusheniem serdechnogo ritma.
PY - 1977
SN - 0044-4588 (Print)
0044-4588
SP - 3-11
ST - [Cerebral circulatory disorders in patients with cardiovascular diseases
accompanied by cardiac rhythm disorders]
T2 - Zh Nevropatol Psikhiatr Im S S Korsakova
TI - [Cerebral circulatory disorders in patients with cardiovascular diseases
accompanied by cardiac rhythm disorders]
VL - 77
ID - 2752
ER -
TY - JOUR
AB - Elevated serum brain natriuretic peptide (BNP) levels are associated with
cardioembolic stroke mainly because of atrial fibrillation (AF). However, the
mechanisms of increased serum BNP levels are hitherto unclear. We aimed to identify
the factors associated with increased BNP levels in patients with acute ischemic
stroke. We measured serum BNP levels in consecutive patients aged 18 years or
older. Stroke subtypes were classified using the Trial of ORG 10172 in Acute Stroke
Treatment criteria. Categorical variables included age, sex, smoking status,
alcohol consumption status, hypertension, diabetes mellitus, dyslipidemia, coronary
artery disease (CAD), AF, antiplatelet therapy, and anticoagulant therapy.
Continuous variables included hemoglobin, creatinine (Cr), β-thromboglobulin,
platelet factor 4, thrombin-antithrombin complex, and d-dimer levels. We further
determined the relationship between serum BNP and intima-media thickness, left
ventricular ejection fraction, size of infarction, National Institutes of Health
Stroke Scale score on admission, and modified Rankin Scale (mRS) score at
discharge. Of the 231 patients (mean age, 71 ± 12 years) with acute ischemic stroke
(AIS), 36% were women. Serum BNP levels significantly correlated with CAD, AF, Cr,
mRS, and cardioembolism (CE) (Dunnett method, P = .004). BNP levels were
significantly higher in patients with larger infarcts, higher mRS scores, and
higher CHADS2 scores. The levels were higher in patients with larger infarcts,
higher mRS scores at discharge, and higher CHADS2 scores among AF patients.
AD - Department of Neurology, Tokyo Women's Medical University School of Medicine,
Tokyo, Japan. Electronic address: kmaruyama@nij.twmu.ac.jp.
Department of Cardiology, Tokyo Women's Medical University School of Medicine,
Tokyo, Japan.
Department of Neurology, Tokyo Women's Medical University School of Medicine,
Tokyo, Japan.
Department of Diagnostic Imaging and Nuclear Medicine, Tokyo Women's Medical
University School of Medicine, Tokyo, Japan.
AN - 24119617
AU - Maruyama, K.
AU - Shiga, T.
AU - Iijima, M.
AU - Moriya, S.
AU - Mizuno, S.
AU - Toi, S.
AU - Arai, K.
AU - Ashihara, K.
AU - Abe, K.
AU - Uchiyama, S.
DA - May-Jun
DP - NLM
ET - 2013/10/15
IS - 5
KW - Aged
Aged, 80 and over
Atrial Fibrillation/blood/complications
Biomarkers/blood
Brain Ischemia/*blood/diagnosis/etiology/physiopathology/therapy
Coronary Artery Disease/blood/complications
Diffusion Magnetic Resonance Imaging
Female
Humans
Kidney/physiopathology
Male
Middle Aged
Risk Factors
Stroke/*blood/diagnosis/etiology/physiopathology/therapy
Treatment Outcome
Up-Regulation
Brain natriuretic peptide
CHADS(2) score
acute ischemic stroke
atrial fibrillation
infarct size
modified Rankin Scale
LA - eng
N1 - 1532-8511
Maruyama, Kenji
Shiga, Tsuyoshi
Iijima, Mutsumi
Moriya, Saori
Mizuno, Satoko
Toi, Sono
Arai, Kotaro
Ashihara, Kyomi
Abe, Kayoko
Uchiyama, Shinichiro
Journal Article
United States
J Stroke Cerebrovasc Dis. 2014 May-Jun;23(5):967-72. doi:
10.1016/j.jstrokecerebrovasdis.2013.08.003. Epub 2013 Oct 8.
PY - 2014
SN - 1052-3057
SP - 967-72
ST - Brain natriuretic peptide in acute ischemic stroke
TI - Brain natriuretic peptide in acute ischemic stroke
VL - 23
ID - 2334
ER -
TY - JOUR
AB - BACKGROUND: Since stroke patients with nonvalvular atrial fibrillation (NVAF)
have poor outcomes in general, the prediction of outcomes following discharge is of
utmost concern for these patients. We previously reported that brain natriuretic
peptide (BNP) levels were significantly higher in NVAF patients with larger
infarcts, higher modified Rankin Scale (mRS) score, and higher CHADS2 score. In the
present study, we evaluated an array of variables, including BNP, in order to
determine significant predictors for functional outcome in patients with NVAF after
acute ischemic stroke (AIS). METHODS: A total of 615 consecutive patients with AIS
within 48 h of symptom onset, admitted to our hospital between April 2010 and
October 2015, were retrospectively searched. Among these patients, we enrolled
consecutive patients with NVAF. We evaluated the mRS score 3 months after onset of
stroke and investigated associations between mRS score and the following clinical
and echocardiographic variables. Categorical variables included male sex, current
smoking, alcohol intake, hypertension, diabetes mellitus, dyslipidemia, coronary
artery disease, peripheral artery disease, use of antiplatelet drugs,
anticoagulants, or tissue plasminogen activator (tPA), and infarct size. Continuous
variables included age, systolic blood pressure (SBP), diastolic blood pressure,
hemoglobin, creatinine, D-dimer, brain natriuretic peptide (BNP), left atrial
diameter, left ventricular ejection fraction (EF), and early mitral inflow
velocity/diastolic mitral annular velocity (E/e'). We also analyzed the association
of prestroke CHADS2, CHA2DS2-VASc, and R2CHADS2 scores, and National Institutes of
Health Stroke Scale (NIHSS) score on admission with mRS score 3 months after the
onset of stroke. Patients were classified into 2 groups according to mRS score: an
mRS score ≤2 was defined as good outcome, an mRS score ≥3 was defined as poor
outcome. To clarify the correlations between categorical or continuous variables
and mRS score, uni- and multivariate logistic regression models using the stepwise
variable selection method were applied. RESULTS: Among 157 patients with NVAF after
AIS, 63.7% were male and the mean age was 75.9 years. In univariate regression
analysis, poor outcome (mRS score ≥3) was associated with use of tPA, infarct size,
age, SBP, BNP, EF, and NIHSS score. In multivariate regression analysis, BNP levels
(odds ratio [OR] 6.40; 95% confidence interval [CI] 1.26-32.43; p = 0.0235) and
NIHSS score (OR 2.87; 95% CI 1.84-4.47; p < 0.001) were significantly associated
with poor outcome (mRS score ≥3) after adjusting for use of tPA, infarct size, age,
BNP, EF, and NIHSS score. CONCLUSIONS: Apart from NIHSS score, BNP was a very
useful predictor for long-term outcomes of patients with NVAF after AIS..
AD - Department of Neurology, Tokyo Women's Medical University School of Medicine,
Tokyo, Japan.
Clinical Research Center, International University of Health and Welfare, Center
for Brain and Cerebral Vessels, Sanno Hospital and Sanno Medical Center, Tokyo,
Japan.
Department of Cardiology, Tokyo Women's Medical University School of Medicine,
Tokyo, Japan.
AN - 28253498
AU - Maruyama, K.
AU - Uchiyama, S.
AU - Shiga, T.
AU - Iijima, M.
AU - Ishizuka, K.
AU - Hoshino, T.
AU - Kitagawa, K.
C2 - PMC5465753
DO - 10.1159/000457808
DP - NLM
ET - 2017/03/03
IS - 1
J2 - Cerebrovascular diseases extra
KW - Aged
Aged, 80 and over
Atrial Fibrillation/*complications/diagnosis
Biomarkers/blood
Female
Humans
Logistic Models
Male
Odds Ratio
Prognosis
Risk Factors
Stroke/*blood/diagnosis/etiology
Time Factors
Brain natriuretic peptide
Modified Rankin Scale score
National Institutes of Health Stroke Scale
Nonvalvular atrial fibrillation
Outcome
Stroke
Systolic blood pressure
LA - eng
N1 - 1664-5456
Maruyama, Kenji
Uchiyama, Shinichiro
Shiga, Tsuyoshi
Iijima, Mutsumi
Ishizuka, Kentaro
Hoshino, Takao
Kitagawa, Kazuo
Journal Article
Cerebrovasc Dis Extra. 2017;7(1):35-43. doi: 10.1159/000457808. Epub 2017 Mar 2.
PY - 2017
SN - 1664-5456
SP - 35-43
ST - Brain Natriuretic Peptide Is a Powerful Predictor of Outcome in Stroke
Patients with Atrial Fibrillation
T2 - Cerebrovasc Dis Extra
TI - Brain Natriuretic Peptide Is a Powerful Predictor of Outcome in Stroke
VL - 7
ID - 2491
ER -
TY - JOUR
AB - Heart failure patients are predisposed to develop arrhythmias.
Supraventricular arrhythmias can exacerbate the heart failure symptoms by
decreasing the effective cardiac output and their control require pharmacological,
electrical, or catheter-based intervention. In the setting of atrial flutter or
atrial fibrillation, anticoagulation becomes paramount to prevent systemic or
cerebral embolism. Patients with heart failure are also prone to develop
ventricular arrhythmias that can present a challenge to the managing clinician. The
management strategy depends on the type of arrhythmia, the underlying structural
heart disease, the severity of heart failure, and the range from optimization of
heart failure therapy to catheter ablation. Patients with heart failure,
irrespective of ejection fraction are at high risk for developing sudden cardiac
death, however risk stratification is a clinical challenge and requires a
multiparametric evaluation for identification of patients who should undergo
implantation of a cardioverter defibrillator. Finally, patients with heart failure
can also develop symptomatic bradycardia, caused by sinus node dysfunction or
atrio-ventricular block. The treatment of bradycardia in these patients with pacing
is usually straightforward but needs some specific issue.
AD - Cardiologia SUN-Heart Failure Unit, Department of Cardiothoracic Sciences,
Second University of Naples, via L. Bianchi, Naples 80100, Italy.
danielemasarone@libero.it.
Cardiologia SUN-Heart Failure Unit, Department of Cardiothoracic Sciences, Second
University of Naples, via L. Bianchi, Naples 80100, Italy.
limongelligiusepppe@libero.it.
University of Naples, via L. Bianchi, Naples 80100, Italy. rubinomarta@libero.it.
University of Naples, via L. Bianchi, Naples 80100, Italy. fabio.valente@alice.it.
rossellavastarella86@gmail.com.
ammendolaernesto@libero.it.
University of Naples, via L. Bianchi, Naples 80100, Italy. ritagravino@libero.it.
University of Naples, via L. Bianchi, Naples 80100, Italy. mariverr@yahoo.it.
University of Naples, via L. Bianchi, Naples 80100, Italy. gemmsalerno@hotmail.com.
University of Naples, via L. Bianchi, Naples 80100, Italy. gpacile@tin.it.
AN - 29367535
AU - Masarone, D.
AU - Limongelli, G.
AU - Rubino, M.
AU - Valente, F.
AU - Vastarella, R.
AU - Ammendola, E.
AU - Gravino, R.
AU - Verrengia, M.
AU - Salerno, G.
AU - Pacileo, G.
C2 - PMC5715690
DA - Feb 28
DO - 10.3390/jcdd4010003
DP - NLM
ET - 2018/01/26
IS - 1
J2 - Journal of cardiovascular development and disease
KW - bradyarrhythmias
heart failure
sudden cardiac death
tachyarrhythmias
LA - eng
N1 - 2308-3425
Masarone, Daniele
Limongelli, Giuseppe
Rubino, Marta
Valente, Fabio
Vastarella, Rossella
Ammendola, Ernesto
Gravino, Rita
Verrengia, Marina
Salerno, Gemma
Pacileo, Giuseppe
Journal Article
Review
J Cardiovasc Dev Dis. 2017 Feb 28;4(1):3. doi: 10.3390/jcdd4010003.
PY - 2017
SN - 2308-3425
ST - Management of Arrhythmias in Heart Failure
T2 - J Cardiovasc Dev Dis
TI - Management of Arrhythmias in Heart Failure
VL - 4
ID - 3080
ER -
TY - JOUR
AB - Atrial fibrillation (AF) increases by fivefold a patient's risk for
thromboembolic stroke. The main source of emboli in AF is the left atrial appendage
(LAA). Therefore, LAA closure could reduce the risk for thromboembolic events in
AF. The investigators report the first United States experience with a novel
percutaneous LAA closure device, the Lariat snare device, and its outcomes in 21
patients with AF, CHADS2 scores ≥2, and contraindications to anticoagulation. The
LAA was closed with a snare containing suture from within the pericardial space.
The intraoperative success of the procedure was confirmed by left atrial
angiography and transesophageal echocardiographic color Doppler flow. The
effectiveness of the procedure was evaluated by follow-up transesophageal
echocardiography. The incidence of periprocedural and short-term complications was
assessed by reviewing medical records. Twenty patients (100%) had successful LAA
exclusion that was preserved at 96 ± 77 days. No patient had a stroke during an
average of 352 ± 143 days of follow-up. One patient had right ventricular
perforation and tamponade that required surgical exploration and repair. Two
patients required prolonged hospitalization: 1 because of pericardial effusion that
required repeat pericardiocentesis and 1 because of noncardiac co-morbidities.
Three patients developed pericarditis <1 month after the procedure, of whom 1 had
associated pericardial effusion that required drainage. In conclusion, percutaneous
LAA exclusion can be achieved successfully and with an acceptable incidence of
periprocedural and short-term complications. Further studies are needed to
determine whether LAA exclusion lowers the long-term risk for thromboembolic events
in patients with AF and contraindications to anticoagulation.
AD - Department of Cardiology, Texas Heart Institute at St. Luke's Episcopal
Hospital, Houston, TX, USA. amassumi@hgcardio.com
AN - 23312129
AU - Massumi, A.
AU - Chelu, M. G.
AU - Nazeri, A.
AU - May, S. A.
AU - Afshar-Kharaghan, H.
AU - Saeed, M.
AU - Razavi, M.
AU - Rasekh, A.
DA - Mar 15
DO - 10.1016/j.amjcard.2012.11.061
DP - NLM
ET - 2013/01/15
IS - 6
KW - Aged
Aged, 80 and over
*Anticoagulants
Atrial Fibrillation/*complications/diagnostic imaging/*surgery
Cardiac Surgical Procedures/*instrumentation
Comorbidity
Contraindications
Echocardiography, Doppler, Color
Humans
Male
Middle Aged
Stroke/*etiology
Suture Techniques
Treatment Outcome
United States
LA - eng
N1 - 1879-1913
Massumi, Ali
Chelu, Mihail Gabriel
Nazeri, Alireza
May, Stephen Allen
Afshar-Kharaghan, Hamid
Saeed, Mohammad
Razavi, Mehdi
Rasekh, Abdi
Journal Article
United States
Am J Cardiol. 2013 Mar 15;111(6):869-73. doi: 10.1016/j.amjcard.2012.11.061. Epub
2013 Jan 9.
PY - 2013
SN - 0002-9149
SP - 869-73
ST - Initial experience with a novel percutaneous left atrial appendage exclusion
device in patients with atrial fibrillation, increased stroke risk, and
contraindications to anticoagulation
T2 - Am J Cardiol
TI - Initial experience with a novel percutaneous left atrial appendage exclusion
device in patients with atrial fibrillation, increased stroke risk, and
contraindications to anticoagulation
VL - 111
ID - 2664
ER -
TY - JOUR
AB - BACKGROUND: The incidence, predictive factors, morbidity, and mortality
associated with the development of supraventricular tachyarrhythmias (SVTs) in
patients with congestive heart failure (CHF) are poorly defined. METHODS: In the
Digitalis Investigation Group trial, patients with CHF who were in sinus rhythm
were randomly assigned to digoxin (n = 3,889) or placebo (n = 3,899) and followed
up for a mean of 37 months. Baseline factors that predicted the occurrence of SVT
and the effects of SVT on total mortality, stroke, and hospitalization for
worsening CHF were determined. RESULTS: Eight hundred sixty-six patients (11.1%)
had SVT during the study period. Older age (odds ratio [OR], 1.029 for each year
increase in age; p = 0.0001), male sex (OR, 1.270; p = 0.0075), increasing duration
of CHF (OR, 1.003 for each month increase in duration of CHF; p = 0.0021), and a
cardiothoracic ratio of > 0.50 (OR, 1.403; p = 0.0001) predicted an increased risk
of experiencing SVT. Left ventricular ejection fraction, New York Heart Association
functional class, and treatment with digoxin vs placebo were not related to the
occurrence of SVT. After adjustment for other risk factors, development of SVT
predicted a greater risk of subsequent total mortality (risk ratio [RR] = 2.451; p
= 0.0001), stroke (RR = 2.352; p = 0.0001), and hospitalization for worsening CHF
(RR = 3. 004; p = 0.0001). CONCLUSION: In CHF patients in sinus rhythm, older age,
male sex, longer duration of CHF, and increased cardiothoracic ratio predict an
increased risk for experiencing SVT. Development of SVT is a strong independent
predictor of mortality, stroke, and hospitalization for CHF in this population.
Prevention of SVT may prolong survival and reduce morbidity in CHF patients.
AD - Department of Medicine, University of Iowa College of Medicine, Iowa City,
USA.
AN - 11035656
AU - Mathew, J.
AU - Hunsberger, S.
AU - Fleg, J.
AU - Mc Sherry, F.
AU - Williford, W.
AU - Yusuf, S.
DA - Oct
DO - 10.1378/chest.118.4.914
DP - NLM
ET - 2000/10/18
IS - 4
J2 - Chest
KW - Age Factors
Aged
Cardiotonic Agents/*therapeutic use
Digoxin/*therapeutic use
Double-Blind Method
Female
Heart Failure/*complications/drug therapy/epidemiology/physiopathology
Humans
Incidence
Male
Middle Aged
Odds Ratio
Prognosis
Sex Factors
Stroke/complications/etiology/prevention & control
Stroke Volume/drug effects
Survival Rate
Tachycardia, Supraventricular/*epidemiology/etiology/physiopathology/prevention &
control
LA - eng
N1 - Mathew, J
Hunsberger, S
Fleg, J
Mc Sherry, F
Williford, W
Yusuf, S
Clinical Trial
Comparative Study
Journal Article
United States
PY - 2000
SN - 0012-3692 (Print)
0012-3692
SP - 914-22
ST - Incidence, predictive factors, and prognostic significance of
supraventricular tachyarrhythmias in congestive heart failure
T2 - Chest
TI - Incidence, predictive factors, and prognostic significance of
supraventricular tachyarrhythmias in congestive heart failure
VL - 118
ID - 2615
ER -
TY - JOUR
AB - Atrial Fibrillation (AF) is a common cardiac arrhythmia and stroke is its
most devasting complication. The rate of ischemic stroke among people with AF is
approximately six times that of people without AF and varies importantely with
coexistent cardiovascular diseases; therefore stratification of AF patients into
those at high and low risk of thromboembolism has become a crucial determinant of
optimal antithrombotic prophylaxis. Multivaria-te analyses of prospective studies
consistently show prior TIA/stroke, diabetes, age, heart failure to be
independently predictive of stroke; left ventricular dysfunction is also strongly
associated with stroke risk. Several randomized clinical trials demonstrated that
treatment with adjusted-dose warfarin reduces the risk of stroke in AF patients by
about two thirds. The efficacy of aspirin for prevention of stroke is
controversial, but supported by pooled results of 3 placebo-controlled trials
yelding a 21% reduction in stroke. The inherent risk of stroke should be considered
in selection of AF patients for lifelong anticoagulation. Patients with AF and a
recent stroke or TIA or multiple risk factors for stroke are likely to benefit from
anticoagulation therapy; at present a target INR 2,5 appears optimal for most
patients, although INR closer to 2.0 may be safer for patients at increased risk
for bleeding events. The addition of aspirin to low- dose warfarin regimen does not
provide any significant benefits and should be avoided. Therapy with aspirin is
appropriate for patients who are at low risk of stroke or are unable to receive
anticoagulants. AF patients treated with aspirin, should be periodically evaluated
for development of high-risk features favoring anticoagulation.
AD - Dipartimento di Scienze Cliniche, Università degli Studi La Sapienza, Rome,
Italy.
AN - 11279381
AU - Matteoli, S.
AU - Trappolini, M.
AU - Chillotti, F. M.
DA - Feb
DP - NLM
ET - 2001/03/30
IS - 1
KW - Age Factors
Aged
Aged, 80 and over
Atrial Fibrillation/*complications/*drug therapy/etiology/therapy
Controlled Clinical Trials as Topic
Humans
Middle Aged
Prevalence
Prospective Studies
Risk Factors
LA - ita
N1 - Matteoli, S
Trappolini, M
Chillotti, F M
Comparative Study
Editorial
English Abstract
Review
Italy
Minerva Cardioangiol. 2001 Feb;49(1):1-13.
OP - Fibrillazione atriale e profilassi tromboembolica. Stato dell'arte.
PY - 2001
SN - 0026-4725 (Print)
0026-4725
SP - 1-13
ST - [Atrial fibrillation and thromboembolic events prevention. State of the art]
TI - [Atrial fibrillation and thromboembolic events prevention. State of the art]
VL - 49
ID - 2709
ER -
TY - JOUR
AB - Patients with sick sinus syndrome have a high prevalence of cerebral ischemia
and emboli of the viscera and extremities. The present study was designed to
establish the prevalence of stroke in patients with sick sinus syndrome, with
specific attention to pacing mode, atrial function (evaluated using Doppler
echocardiography) and the clinical condition of the patients. The prospective study
analyzed 80 consecutive patients with sick sinus syndrome who received either
atrial, dual chamber or ventricular pacemakers. Patients underwent a cranial CT
scan at the time of enrollment and again at the end of the study 24 months later.
End points of the study were cerebral ischemia or emboli of the viscera or
extremities. Clinical and echocardiographic features were assessed at the beginning
of the study. A multivariate regression analysis was applied to all variables that
had at least a marginal univariate predictive value. Cerebral ischemia occurred in
13 patients and emboli of the viscera or extremities were observed in 2 patients.
Univariate predictors for embolism consisted of a prior history of cerebrovascular
disease (p < 0.001), low atrial ejection force (p < 0.01) and a dilated left atrium
with spontaneous echo contrast (p < 0.05). Independent risk factors for stroke
included a history of previous cerebral ischemia, age > 65 years, left atrial echo
contrast on an echocardiogram and a depressed atrial ejection force. These findings
identified patients at high risk for the development of peripheral embolism among
the group of patients paced for sick sinus syndrome.
AD - Department of Cardiology, University of Modena, Italy.
AN - 9129848
AU - Mattioli, A. V.
AU - Castellani, E. T.
AU - Fusco, A.
AU - Paolillo, C.
AU - Mattioli, G.
DA - May-Jun
DO - 10.1159/000177341
DP - NLM
ET - 1997/05/01
IS - 3
J2 - Cardiology
KW - Adolescent
Adult
Aged
Cerebrovascular Disorders/diagnostic imaging/epidemiology/*etiology
Extremities/blood supply
Female
Follow-Up Studies
Hemodynamics
Humans
Incidence
Male
Middle Aged
Prevalence
Prospective Studies
Regression Analysis
Risk Factors
Sick Sinus Syndrome/*complications/diagnostic imaging/therapy
Thromboembolism/diagnosis/etiology
Viscera/blood supply
LA - eng
N1 - Mattioli, A V
Castellani, E T
Fusco, A
Paolillo, C
Mattioli, G
Journal Article
Switzerland
Cardiology. 1997 May-Jun;88(3):264-70. doi: 10.1159/000177341.
PY - 1997
SN - 0008-6312 (Print)
0008-6312
SP - 264-70
ST - Stroke in paced patients with sick sinus syndrome: relevance of atrial
mechanical function, pacing mode and clinical characteristics
T2 - Cardiology
TI - Stroke in paced patients with sick sinus syndrome: relevance of atrial
mechanical function, pacing mode and clinical characteristics
VL - 88
ID - 2911
ER -
TY - JOUR
AB - Several studies reported that the annual incidence of stroke in patients with
sick sinus syndrome ranges from 6 to 10% while the incidence of stroke in patients
with atrial fibrillation is about 2-4% and about 0.1% in the normal population. We
evaluated the prevalence of cerebral ischemia and peripheral embolism and
investigated the predictor factors in a population of 80 patients paced for sick
sinus syndrome. The implanted pacemakers were 40 ventricular and 40 physiological
stimulation mode was based on the physicians judgement. All patients had cerebral
computed tomography scan at the time of implant and after 24 months. Statistical
analysis included log-rank test and actuarial curve calculated with Mantel-Haenszel
method. At the end of follow-up the end-point occurred in 15 patients: 2 patients
had asymptomatic cerebral infarction, 2 had fatal stroke, 2 developed peripheral
embolysm, 1 to the lower limb and 1 abdominal; in 4 patients a transient ischemic
attack occurred, in 2 a minor stroke and in 3 a non invalidant stroke. No
statistically significant difference was found among the subgroups; with different
pacing modality. In conclusion, multivariate analysis underlines the role of age >
65 years, history of cerebral ischemia, low atrial ejection force and spontaneous
echo contrast in the development of embolic episodes.
AD - Cattedra di Cardiologia, Università degli Studi, Modena.
AN - 7671276
AU - Paolillo, C.
AU - Fusco, A.
AU - Molinari, R.
AU - Palladini, G.
AU - Mattioli, G.
DA - Feb
DP - NLM
ET - 1995/02/01
IS - 2
J2 - Cardiologia (Rome, Italy)
KW - Aged
Cerebrovascular Disorders/epidemiology/*etiology
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prevalence
Sick Sinus Syndrome/*complications/therapy
LA - ita
N1 - Mattioli, A V
Castellani, E T
Paolillo, C
Fusco, A
Molinari, R
Palladini, G
Mattioli, G
English Abstract
Journal Article
Italy
Cardiologia. 1995 Feb;40(2):123-8.
OP - Lo stroke nei portatori di pacemaker per malattia del nodo del seno.
Rilevanza della funzione meccanica atriale e delle caratteristiche cliniche.
PY - 1995
SN - 0393-1978 (Print)
0393-1978
SP - 123-8
ST - [Stroke in pacemaker users for sinus node disease. Relevance of atrial
function and clinical characteristics]
T2 - Cardiologia
TI - [Stroke in pacemaker users for sinus node disease. Relevance of atrial
function and clinical characteristics]
VL - 40
ID - 2810
ER -
TY - JOUR
AB - BACKGROUND: Several reports suggest that the incidence of stroke and atrial
fibrillation is reduced in patients receiving physiologic pacemakers, compared with
patients receiving a ventricular pacemaker. HYPOTHESIS: The study was undertaken to
address the impact of different pacing modalities on the incidence of stroke and
atrial fibrillation. METHODS: We prospectively analyzed 210 consecutive patients.
Those with previous episodes of cerebral ischemia and/or atrial fibrillation were
excluded from the study. The study population included 100 patients paced for total
atrioventricular (AV) block or second-degree AV block (type II Mobitz) and 110
patients paced for sick sinus syndrome (SSS). The pacing mode was randomized. All
patients underwent a brain computed tomography (CT) scan at the date of enrollment
and after 1 and 2 years. Patients were followed for 2 years, and the incidence of
atrial fibrillation and stroke was evaluated. RESULTS: The incidence of atrial
fibrillation was 10% at 1 year and 11% at 2 years. Comparing the different pacing
modalities, we reported an increase in the incidence of atrial fibrillation in
patients receiving ventricular pacing (p < 0.05). On the other hand, no difference
was found between patients paced for AV block and those paced for SSS. At the end
of follow-up, we reported 29 cases of cerebral ischemia: 9 patients had AV block
while 20 had SSS (p < 0.05). Comparing the different pacing modalities, there was
an increase in the incidence of stroke in patients receiving ventricular pacing (p
< 0.05). CONCLUSION: There was an increase in the incidence of stroke and atrial
fibrillation in patients with ventricular pacing.
AN - 9491951
AU - Vivoli, D.
AU - Sgura, F. A.
AU - Mattioli, G.
C2 - PMC6656022
DA - Feb
DO - 10.1002/clc.4960210210
DP - NLM
ET - 1998/03/10
IS - 2
KW - Aged
Atrial Fibrillation/*epidemiology/etiology/physiopathology
Brain Ischemia/diagnostic imaging/*epidemiology/etiology
Cardiac Pacing, Artificial/*adverse effects
Chronic Disease
Female
Follow-Up Studies
Heart Block/therapy
Humans
Incidence
Male
Prevalence
Prospective Studies
Sick Sinus Syndrome/therapy
LA - eng
N1 - 1932-8737
Mattioli, A V
Castellani, E T
Vivoli, D
Sgura, F A
Mattioli, G
Clinical Trial
Comparative Study
Journal Article
Clin Cardiol. 1998 Feb;21(2):117-22. doi: 10.1002/clc.4960210210.
PY - 1998
SN - 0160-9289 (Print)
0160-9289
SP - 117-22
ST - Prevalence of atrial fibrillation and stroke in paced patients without prior
atrial fibrillation: a prospective study
T2 - Clin Cardiol
TI - Prevalence of atrial fibrillation and stroke in paced patients without prior
atrial fibrillation: a prospective study
VL - 21
ID - 2676
ER -
TY - JOUR
AB - Patients with sick sinus syndrome have a high prevalence of cerebral
ischemia. The present study was designed to establish the prevalence of stroke in
patients with sick sinus syndrome and the role of atrial size and function. This
prospective study analyzed 100 consecutive patients with sick sinus syndrome
without atrial fibrillation who received either dual chamber or ventricular
pacemakers. Patients underwent a cranial CT scan at the time of enrollment and
again at the end of the study 24 months later. Endpoint of the study was cerebral
ischemia. Clinical and echocardiographic features were assessed at the beginning of
the study. A multivariate regression analysis was applied to all variables that had
at least a marginal univariate predictive value. Cerebral ischemia occurred in 18
patients. Univariate predictors for embolism were age >65 years (p < 0.001), low
atrial ejection force (p < 0.01) and a dilated left atrium with spontaneous echo
contrast (p < 0.05). These findings identified patients at high risk for the
development of peripheral embolism among the group of patients paced for sick sinus
syndrome.
mattioli.anna.vittoria@unimo.it
AN - 10516407
AU - Tarabini Castellani, E.
AU - Mattioli, G.
DO - 10.1159/000006902
DP - NLM
ET - 1999/10/12
IS - 3
J2 - Cardiology
KW - Aged
Female
Humans
Male
Middle Aged
Prospective Studies
Sick Sinus Syndrome/*complications/diagnostic imaging/therapy
Ultrasonography
LA - eng
N1 - Mattioli, A V
Tarabini Castellani, E
Mattioli, G
Journal Article
Switzerland
Cardiology. 1999;91(3):150-5. doi: 10.1159/000006902.
PY - 1999
SN - 0008-6312 (Print)
0008-6312
SP - 150-5
ST - Stroke in paced patients with sick sinus syndrome: influence of left atrial
function and size
T2 - Cardiology
TI - Stroke in paced patients with sick sinus syndrome: influence of left atrial
function and size
VL - 91
ID - 2663
ER -
TY - JOUR
AB - Hypothermia is generally defined as a core body temperature less than 35
degrees C (95 degrees F). Hypothermia is one of the most common environmental
emergencies encountered by emergency physicians. Although the diagnosis will
usually be evident after an initial check of vital signs, the diagnosis can
sometimes be missed because of overreliance on normal or near-normal oral or
tympanic thermometer readings. The classic and well-known electrocardiographic
(ECG) manifestations of hypothermia include the presence of J (Osborn) waves,
interval (PR, QRS, QT) prolongation, and atrial and ventricular dysrhythmias. There
are also some less known (ECG) findings associated with hypothermia. For example,
hypothermia can produce ECG signs that simulate those of acute myocardial ischemia
or myocardial infarction. Hypothermia can also blunt the expected ECG findings
associated with hyperkalemia. A thorough knowledge of these findings is important
for prompt diagnosis and treatment of hypothermia. Six cases are presented that
show these important ECG manifestations of hypothermia.
AD - Division of Emergency Medicine, Department of Surgery, University of Maryland
School of Medicine, Baltimore, MD, USA.
AN - 12098179
AU - Mattu, A.
AU - Brady, W. J.
AU - Perron, A. D.
DA - Jul
DO - 10.1053/ajem.2002.32633
DP - NLM
ET - 2002/07/05
IS - 4
KW - Adult
Aged
Dementia, Multi-Infarct/complications
Female
Homeless Persons
Humans
Hyperkalemia/complications/diagnosis
Hypothermia/*complications/*diagnosis/etiology
Male
Middle Aged
Substance-Related Disorders/complications
LA - eng
N1 - Mattu, Amal
Brady, William J
Perron, Andrew D
Case Reports
Journal Article
Review
United States
Am J Emerg Med. 2002 Jul;20(4):314-26. doi: 10.1053/ajem.2002.32633.
PY - 2002
SN - 0735-6757 (Print)
0735-6757
SP - 314-26
ST - Electrocardiographic manifestations of hypothermia
T2 - Am J Emerg Med
TI - Electrocardiographic manifestations of hypothermia
VL - 20
ID - 2520
ER -
TY - JOUR
AB - INTRODUCTION: Takotsubo syndrome is a transient stress cardiomyopathy
associated with a distinctive left ventricular contraction pattern. It has been
described as a cardioembolic source or as a consequence of stroke. Two patients are
reported that illustrate the reciprocal relationship between Takotsubo syndrome and
stroke and the physiopathological mechanisms implicated are analyzed. CASE REPORTS:
Two women aged 70 and 78 years respectively are described. The first one was
admitted with electro-cardiogram ST-segment elevation, slight troponin elevation
and stroke symptoms. Ecocardiography and cardiac magnetic resonance findings were
consistent with Takotsubo syndrome that was the probable source of cardioembolic
stroke. The second patient suffered a Takotsubo syndrome 72 hours after a brain
infarction involving the insular cortex that was considered the trigger of
Takotsubo syndrome. CONCLUSIONS: Takotsubo syndrome and stroke may have a
reciprocal etiological relationship that is suggested by the temporal profile
between the two processes. Cardiac magnetic resonance may aid in the establishment
of the diagnosis of Takotsubo syndrome.
AD - Servicio de Neurología, Complejo Hospitalario de Navarra, Irunlarrea, 3. E-
31008 Pamplona Navarra, España. sergiomirneurologia@hotmail.com
AN - 23055429
AU - Mayor-Gómez, S.
AU - Erro, M. E.
AU - Olaz-Preciado, F.
AU - Ciriza-Esandi, M.
AU - Gállego-Culleré, J.
DA - Oct 16
DP - NLM
ET - 2012/10/12
IS - 8
J2 - Revista de neurologia
KW - Aged
Aged, 80 and over
Causality
Cerebral Cortex/blood supply
Cerebral Infarction/*complications/diagnostic imaging
Dysarthria/etiology
Dyslipidemias/complications
Electrocardiography
Female
Humans
Infarction, Posterior Cerebral Artery/diagnostic imaging/*etiology
Paresis/etiology
Takotsubo Cardiomyopathy/*complications/diagnosis/diagnostic imaging/pathology
Ultrasonography
LA - spa
N1 - 1576-6578
Mayor-Gómez, Sergio
Erro, María Elena
Olaz-Preciado, Fernando
Ciriza-Esandi, Mercedes
Gállego-Culleré, Jaime
Case Reports
Journal Article
Spain
Rev Neurol. 2012 Oct 16;55(8):475-8.
OP - Ictus y síndrome de takotsubo: una relación recíproca.
PY - 2012
SN - 0210-0010
SP - 475-8
ST - [Stroke and Takotsubo syndrome: a reciprocal relationship]
T2 - Rev Neurol
TI - [Stroke and Takotsubo syndrome: a reciprocal relationship]
VL - 55
ID - 2477
ER -
TY - JOUR
AB - Although infrequent, embolic occlusion to non-cerebral arteries may result in
limb loss, organ failure, and death. The aim of this study was to define clinical
and echocardiographic characteristics determining thromboembolism destination in
non-valvular atrial fibrillation. An inception cohort of individuals (n=72) were
identified with incident peripheral embolism in the setting of non-valvular atrial
fibrillation (1995-2005). A randomly selected group of atrial fibrillation related
stroke patients (n=100) were identified for comparison. Arteries of the extremities
were the most common site of embolism (85%); lower extremity involvement was twice
as common compared with the upper extremity. Clinical features distinguishing
peripheral embolism from stroke included age>75, heart failure and hypertension.
Severe left ventricular dysfunction, spontaneous echo contrast and left atrial
thrombus were 2-3 fold more common in peripheral embolism patients. Mean CHADS-2
scores were low and comparable for both groups. By multivariate analysis, age>5
years (hazard ratio [HR] 2.3, 95% confidence interval [CI] 1.3-3.9; p=0.05) was
predictive of peripheral embolism. After adjustment for age>75 years, severe left
atrial enlargement (HR 1.8, 95% CI 0.99-3.1; p=0.055) and CHADS score (HR 1.2, 95%
CI 0.99-1.6; p=0.06) were of borderline significance. In conclusion, several
clinical and echocardiographic measures distinguish the clinical presentation of
thromboembolism in non-valvular atrial fibrillation. Small emboli are destined to
lodge in the cerebral circulation as a result of hydrodynamic, anatomic, and
physical factors. Advanced age, atrial enlargement and other co-morbidities may
increase the propensity for the formation of larger thrombi which may bypass the
carotid orifice merely as a function of size.
AD - Division of Cardiovascular Medicine, Department of Health Sciences Research,
Mayo Clinic and Foundation for Education and Research, 200 First Street S.W.,
Rochester, MN 55905, USA.
AN - 18449427
AU - McBane, R. D.
AU - Hodge, D. O.
AU - Wysokinski, W. E.
DA - May
DO - 10.1160/th07-12-0734
DP - NLM
ET - 2008/05/02
IS - 5
J2 - Thrombosis and haemostasis
KW - Age Factors
Aged
Aged, 80 and over
Arterial Occlusive Diseases/diagnostic imaging/*etiology/therapy
Atrial Fibrillation/complications/*diagnostic imaging/therapy
Extremities/*blood supply
Female
Heart Failure/complications/diagnostic imaging
Humans
Hypertension/complications/diagnostic imaging
Male
Risk Assessment
Risk Factors
Stroke/diagnostic imaging/*etiology/therapy
Thromboembolism/*complications/diagnostic imaging/etiology/therapy
LA - eng
N1 - McBane, Robert D
Hodge, David O
Wysokinski, Waldemar E
Comparative Study
Journal Article
Germany
Thromb Haemost. 2008 May;99(5):951-5. doi: 10.1160/TH07-12-0734.
PY - 2008
SN - 0340-6245 (Print)
0340-6245
SP - 951-5
ST - Clinical and echocardiographic measures governing thromboembolism destination
in atrial fibrillation
T2 - Thromb Haemost
TI - Clinical and echocardiographic measures governing thromboembolism destination
in atrial fibrillation
VL - 99
ID - 2665
ER -
TY - JOUR
AB - Peer-reviewed data pertaining to anti-thrombotic and interventional therapy
for transient ischaemic attack (TIA) or ischaemic stroke patients with non-valvular
atrial fibrillation, atrial flutter, interatrial septal abnormalities, or left
ventricular thrombus were reviewed. Long-term oral anticoagulant therapy with
warfarin is the treatment of choice for secondary stroke prevention following TIA
or minor ischaemic stroke in association with persistent or paroxysmal non-valvular
atrial fibrillation or atrial flutter. If warfarin is contraindicated, long-term
aspirin is a safe, but much less effective alternative treatment option in this
subgroup of patients with cerebrovascular disease. Management of young patients
with TIA or stroke in association with an interatrial septal defect is
controversial. Various treatment options are outlined, but readers are encouraged
to include these patients in one of the ongoing randomised clinical trials in this
area. It is reasonable to consider empirical anticoagulation in patients with TIA
or ischaemic stroke in association with left ventricular thrombus formation
following myocardial infarction or in association with idiopathic dilated
cardiomyopathy. If warfarin is prescribed, one should aim for a target
international normalised ratio of 2.5 (range 2-3) to achieve the best balance
between adequate secondary prevention of cardioembolic events and the risk of major
haemorrhagic complications.
AD - Department of Neurology, The Adelaide and Meath Hospital Tallaght, Trinity
College Dublin, Dublin 24, Republic of Ireland. dominick.mccabe@amnch.ie
AN - 17172564
AU - McCabe, D. J.
AU - Rakhit, R. D.
C2 - PMC2117792
DA - Jan
DO - 10.1136/jnnp.2006.092031
DP - NLM
ET - 2006/12/19
IS - 1
J2 - Journal of neurology, neurosurgery, and psychiatry
KW - Age Factors
Atrial Appendage/surgery
Heart Septal Defects, Atrial/complications
Humans
Intracranial Embolism/complications/etiology
Ischemic Attack, Transient/*drug therapy/etiology
Stroke/*drug therapy/etiology
Thrombosis/complications
LA - eng
N1 - 1468-330x
McCabe, D J H
Rakhit, R D
Journal Article
Review
J Neurol Neurosurg Psychiatry. 2007 Jan;78(1):14-24. doi: 10.1136/jnnp.2006.092031.
PY - 2007
SN - 0022-3050 (Print)
0022-3050
SP - 14-24
ST - Antithrombotic and interventional treatment options in cardioembolic
transient ischaemic attack and ischaemic stroke
T2 - J Neurol Neurosurg Psychiatry
TI - Antithrombotic and interventional treatment options in cardioembolic
transient ischaemic attack and ischaemic stroke
VL - 78
ID - 2391
ER -
TY - JOUR
AB - BACKGROUND AND PURPOSE: The most well-known stroke risk score is the
Framingham Stroke Risk Score (FSRS), which was developed during the higher stroke
risk period of the 1990s and has not been validated for blacks. We assessed the
performance of the FSRS among participants in the Reasons for Geographic and Racial
Differences in Stroke (REGARDS) study to determine whether it is useful in both
blacks and whites. METHODS: Expected annualized stroke rates from the FSRS were
compared with observed stroke rates overall and within strata defined by FSRS risk
factors (age, sex, systolic blood pressure, use of antihypertensive medications,
diabetes mellitus, smoking, atrial fibrillation, left ventricular hypertrophy, and
prevalent coronary heart disease). RESULTS: Among 27 748 participants stroke-free
at baseline, 715 stroke events occurred over 5.6 years of follow-up. FSRS-estimated
incidence rates of stroke were 1.6× higher than observed for black men, 1.9× higher
for white men, 1.7× higher for black women, and 1.7× higher for white women. This
overestimation was consistent among most subgroups of FSRS factors, although the
magnitude of overestimation varied by the risk factor assessed. CONCLUSIONS:
Although higher FSRS was associated with higher stroke risk, the FSRS overestimated
the observed stroke rates in this study, particularly in certain subgroups. This
may be because of temporal declines in stroke rates, secular trends in prevention
treatments, or differences in populations studied. More accurate estimates of event
rates are critical for planning research, including clinical trials, and targeting
health-care efforts.
AD - From the Department of Biostatistics, University of Alabama at Birmingham
(L.A.M., G.H.); Department of Neurology, University of Cincinnati, OH (D.O.K.,
B.M.K.); Department of Medicine, University of Vermont, Burlington (M.C.); and
Department of Epidemiology and Prevention, Wake Forest University School of
Medicine, Winston-Salem, NC (E.Z.S.). lmcclure@uab.edu.
From the Department of Biostatistics, University of Alabama at Birmingham (L.A.M.,
G.H.); Department of Neurology, University of Cincinnati, OH (D.O.K., B.M.K.);
Department of Medicine, University of Vermont, Burlington (M.C.); and Department of
Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-
Salem, NC (E.Z.S.).
AN - 24736237
AU - McClure, L. A.
AU - Kleindorfer, D. O.
AU - Kissela, B. M.
AU - Cushman, M.
AU - Soliman, E. Z.
AU - Howard, G.
C2 - PMC4102650
C6 - NIHMS577283
DA - Jun
DO - 10.1161/strokeaha.114.004915
DP - NLM
ET - 2014/04/17
IS - 6
J2 - Stroke
KW - Adult
Age Factors
Aged
Atrial Fibrillation/complications/epidemiology/ethnology/physiopathology
Blood Pressure
Coronary Disease/complications/epidemiology/ethnology/physiopathology
Female
Humans
Hypertrophy, Left Ventricular/complications/epidemiology/ethnology/physiopathology
Male
Middle Aged
Risk Factors
Sex Factors
Smoking/adverse effects/epidemiology/ethnology/physiopathology
*Stroke/epidemiology/ethnology/etiology/physiopathology
risk assessment
stroke
LA - eng
N1 - 1524-4628
McClure, Leslie A
Kleindorfer, Dawn O
Kissela, Brett M
Cushman, Mary
Soliman, Elsayed Z
Howard, George
U01NS041588/NS/NINDS NIH HHS/United States
Clinical Trial
Journal Article
Multicenter Study
Stroke. 2014 Jun;45(6):1716-20. doi: 10.1161/STROKEAHA.114.004915. Epub 2014 Apr
15.
PY - 2014
SN - 0039-2499 (Print)
0039-2499
SP - 1716-20
ST - Assessing the performance of the Framingham Stroke Risk Score in the reasons
for geographic and racial differences in stroke cohort
T2 - Stroke
TI - Assessing the performance of the Framingham Stroke Risk Score in the reasons
for geographic and racial differences in stroke cohort
VL - 45
ID - 2345
ER -
TY - JOUR
AB - The prevalence of cardiovascular disease, including cardiac arrhythmia,
coronary artery disease, cardiomyopathy, and valvular heart disease, is higher in
hemodialysis (HD) patients than in the US resident population. Cardiovascular
disease is the leading cause of death in HD patients and the principal discharge
diagnosis accompanying 1 in 4 hospital admissions. Furthermore, the rate of
hospital admissions for either heart failure or fluid overload is persistently high
despite widespread use of β-blockers and renin-angiotensin system inhibitors and
attempts to manage fluid overload with ultrafiltration. An important predictor of
cardiovascular mortality and morbidity in dialysis patients is left ventricular
hypertrophy (LVH). LVH is an adaptive response to increased cardiac work, typically
caused by combined pressure and volume overload, resulting in cardiomyocyte
hypertrophy and increased intercellular matrix. In new dialysis patients, the
prevalence of LVH is 75%. Regression of LVH may reduce cardiovascular risk,
including the incidence of heart failure, complications after myocardial
infarction, and sudden arrhythmic death. Multiple randomized clinical trials show
that intensive HD reduces left ventricular mass, a measure of LVH. Short daily and
nocturnal schedules in the Frequent Hemodialysis Network trial reduced left
ventricular mass by 14 (10%) and 11 (8%) g, respectively, relative to 3 sessions
per week. Comparable efficacy was observed in an earlier trial of nocturnal HD.
Intensive HD also improves cardiac rhythm. Clinical benefits have been reported
only in observational studies. Daily home HD is associated with 17% and 16% lower
risks for cardiovascular death and hospitalization, respectively; admissions for
cerebrovascular disease, heart failure, and hypertensive disease, which
collectively constitute around half of cardiovascular hospitalizations, were less
likely with daily home HD. Relative to peritoneal dialysis, daily home HD is
likewise associated with lower risk for cardiovascular hospitalization. In
conclusion, intensive HD likely reduces left ventricular mass and may lead to lower
risks for adverse cardiac events.
AD - Baylor University Medical Center, Dallas, TX; Baylor Heart and Vascular
Institute, Dallas, TX; Baylor Jack and Jane Hamilton Heart and Vascular Hospital,
Dallas, TX; The Heart Hospital Baylor Plano, Plano, TX.
Division of Nephrology, Department of Medicine, University Health Network, Toronto,
Canada.
Department of Pharmaceutical Care and Health Systems, College of Pharmacy,
University of Minnesota, Minneapolis, MN. Electronic address: wein0205@umn.edu.
Wake Forest University Medical Center, Winston-Salem, NC.
American Society of Hypertension Comprehensive Hypertension Center, Section of
Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of
Chicago Medicine, Chicago, IL.
AN - 27772643
AU - McCullough, P. A.
AU - Chan, C. T.
AU - Weinhandl, E. D.
AU - Burkart, J. M.
AU - Bakris, G. L.
DA - Nov
DO - 10.1053/j.ajkd.2016.05.025
DP - NLM
ET - 2016/10/25
IS - 5s1
Kidney Foundation
KW - Cardiovascular Diseases/*complications/epidemiology
Humans
Hypertrophy, Left Ventricular/*complications/physiopathology
Kidney Failure, Chronic/*complications/*therapy
*Renal Dialysis/methods
*Cardiac arrhythmia
*Frequent Hemodialysis Network
*cardiovascular disease
*chronic kidney disease
*daily dialysis
*end-stage renal disease
*fluid overload
*heart failure
*heart rhythm
*home dialysis
*intensive hemodialysis
*nocturnal hemodialysis
*review
*short daily hemodialysis
LA - eng
N1 - 1523-6838
McCullough, Peter A
Chan, Christopher T
Weinhandl, Eric D
Burkart, John M
Bakris, George L
Journal Article
Review
United States
Am J Kidney Dis. 2016 Nov;68(5S1):S5-S14. doi: 10.1053/j.ajkd.2016.05.025.
PY - 2016
SN - 0272-6386
SP - S5-s14
ST - Intensive Hemodialysis, Left Ventricular Hypertrophy, and Cardiovascular
Disease
TI - Intensive Hemodialysis, Left Ventricular Hypertrophy, and Cardiovascular
Disease
VL - 68
ID - 3098
ER -
TY - JOUR
AB - BACKGROUND AND PURPOSE: Forty percent of patients with a history of ischemic
stroke or transient ischemic attack (TIA) have concomitant coronary artery disease.
ST segment depression, detected by continuous electrocardiography, is associated
with increased cardiac morbidity and mortality in patients with known coronary
artery disease. While electrocardiographic changes have been associated with acute
stroke, the etiology and significance of these changes remain unclear. In this
pilot study we report the prevalence of ST segment depression and ventricular
arrhythmias in patients with acute ischemic stroke or TIA monitored by continuous
electrocardiography. Clinical predictors of ST segment depression and ventricular
arrhythmia are also identified. METHODS: Consecutive patients presenting with acute
ischemic stroke or TIA were enrolled within 72 hours of hospital admission and
monitored by continuous electrocardiography for 48 hours. The electrocardiographic
results were analyzed for periods of ST segment depression and ventricular
arrhythmias. RESULTS: Of 51 patients with ischemic stroke or TIA, 15 (29%) had
episodes of ST segment depression (95% confidence interval, 15% to 43%), and 18
(35%) had ventricular arrhythmias (95% confidence interval, 21% to 49%). In
logistic regression analysis, increasing age (P < .02) and a left-sided
neurological event (P < .01) were significant predictors of ST segment depression.
Increasing numbers of atherosclerotic risk factors, a history of cardiac disease,
and increasing or decreasing mean arterial pressure were not predictive of ST
segment depression. CONCLUSIONS: Patients with acute ischemic stroke or TIA have a
29% prevalence of ST segment depression within the first 5 days after their event.
In comparison, the prevalence of ST depression is 2.5% to 8% in asymptomatic adults
and 43% to 60% in patients with symptomatic coronary artery disease. The
association of ST segment depression with left-sided neurological events suggests
that the electrocardiographic changes are in part neurologically mediated. Further
study is necessary to better define the brain-heart interaction and to determine
whether ST segment depression in patients with ischemic stroke or TIA reflects
underlying coronary artery disease.
AD - Division of General Internal Medicine, Northwestern University Medical
School, Chicago, Ill.
AN - 8073463
AU - McDermott, M. M.
AU - Lefevre, F.
AU - Arron, M.
AU - Martin, G. J.
AU - Biller, J.
DA - Sep
DO - 10.1161/01.str.25.9.1820
DP - NLM
ET - 1994/09/01
IS - 9
J2 - Stroke
KW - Acute Disease
Aged
Blood Pressure
Coronary Disease/complications/*physiopathology
Humans
Ischemic Attack, Transient/*physiopathology
Middle Aged
Regression Analysis
Time Factors
LA - eng
N1 - McDermott, M M
Lefevre, F
Arron, M
Martin, G J
Biller, J
Comparative Study
Journal Article
United States
Stroke. 1994 Sep;25(9):1820-4. doi: 10.1161/01.str.25.9.1820.
PY - 1994
SN - 0039-2499 (Print)
0039-2499
SP - 1820-4
ST - ST segment depression detected by continuous electrocardiography in patients
with acute ischemic stroke or transient ischemic attack
T2 - Stroke
TI - ST segment depression detected by continuous electrocardiography in patients
with acute ischemic stroke or transient ischemic attack
VL - 25
ID - 2475
ER -
TY - JOUR
AB - BACKGROUND: Atrial fibrillation (AF) and heart failure (HF) are 2 of the most
common cardiovascular conditions nationally and AF frequently complicates HF. We
examined how AF has impacts on adverse outcomes in HF-PEF versus HF-REF within a
large, contemporary cohort. METHODS AND RESULTS: We identified all adults diagnosed
with HF-PEF or HF-REF based on hospital discharge and ambulatory visit diagnoses
and relevant imaging results for 2005-2008 from 4 health plans in the
Cardiovascular Research Network. Data on demographic features, diagnoses,
procedures, outpatient pharmacy use, and laboratory results were ascertained from
health plan databases. Hospitalizations for HF, stroke, and any reason were
identified from hospital discharge and billing claims databases. Deaths were
ascertained from health plan and state death files. Among 23 644 patients with HF,
11 429 (48.3%) had documented AF (9081 preexisting, 2348 incident). Compared with
patients who did not have AF, patients with AF had higher adjusted rates of
ischemic stroke (hazard ratio [HR] 2.47 for incident AF; HR 1.57 for preexisting
AF), hospitalization for HF (HR 2.00 for incident AF; HR 1.22 for preexisting AF),
all-cause hospitalization (HR 1.45 for incident AF; HR 1.15 for preexisting AF),
and death (incident AF HR 1.67; preexisting AF HR 1.13). The associations of AF
with these outcomes were similar for HF-PEF and HF-REF, with the exception of
ischemic stroke. CONCLUSIONS: AF is a potent risk factor for adverse outcomes in
patients with HF-PEF or HF-REF. Effective interventions are needed to improve the
prognosis of these high-risk patients.
AD - Division of Cardiovascular Medicine, Department of Medicine, University of
Massachusetts Medical Center, Worcester, MA 01655, USA. mcmanusd@ummhc.org
AN - 23525446
AU - McManus, D. D.
AU - Hsu, G.
AU - Sung, S. H.
AU - Saczynski, J. S.
AU - Smith, D. H.
AU - Magid, D. J.
AU - Gurwitz, J. H.
AU - Goldberg, R. J.
AU - Go, A. S.
C2 - PMC3603249
DA - Feb 1
DO - 10.1161/jaha.112.005694
DP - NLM
ET - 2013/03/26
IS - 1
KW - Aged
Aged, 80 and over
Atrial Fibrillation/diagnosis/*epidemiology/mortality/physiopathology/therapy
Female
Heart Failure/diagnosis/*epidemiology/mortality/physiopathology/therapy
Hospitalization
Humans
Incidence
Male
Middle Aged
Prognosis
Risk Assessment
Risk Factors
Stroke/epidemiology
*Stroke Volume
Time Factors
LA - eng
N1 - 2047-9980
McManus, David D
Hsu, Grace
Sung, Sue Hee
Saczynski, Jane S
Smith, David H
Magid, David J
Gurwitz, Jerry H
Goldberg, Robert J
Go, Alan S
Cardiovascular Research Network PRESERVE Study
1RC1HL099395/HL/NHLBI NIH HHS/United States
KL2RR031981/RR/NCRR NIH HHS/United States
K01AG33643/AG/NIA NIH HHS/United States
RC1 HL099395/HL/NHLBI NIH HHS/United States
U19 HL91179-01/HL/NHLBI NIH HHS/United States
1U01HL10 5268-01/HL/NHLBI NIH HHS/United States
KL2 RR031981/RR/NCRR NIH HHS/United States
Comparative Study
Journal Article
Multicenter Study
J Am Heart Assoc. 2013 Feb 1;2(1):e005694. doi: 10.1161/JAHA.112.005694.
PY - 2013
SN - 2047-9980
SP - e005694
ST - Atrial fibrillation and outcomes in heart failure with preserved versus
reduced left ventricular ejection fraction
TI - Atrial fibrillation and outcomes in heart failure with preserved versus
reduced left ventricular ejection fraction
VL - 2
ID - 2481
ER -
TY - JOUR
AB - BACKGROUND: We examined the risk of stroke or systemic embolism (SSE)
conferred by heart failure (HF) and left ventricular systolic dysfunction (LVSD) in
the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial
Fibrillation Trial (ARISTOTLE), as well as the effect of apixaban versus warfarin.
METHODS AND RESULTS: The risk of a number of outcomes, including the composite of
SSE or death (to take account of competing risks) and composite of SSE, major
bleeding, or death (net clinical benefit) were calculated in 3 patient groups: (1)
no HF/no LVSD (n=8728), (2) HF/no LVSD (n=3207), and (3) LVSD with/without
symptomatic HF (n=2736). The rate of both outcomes was highest in patients with
LVSD (SSE or death 8.06; SSE, major bleeding, or death 10.46 per 100 patient-
years), intermediate for HF but preserved LV systolic function (5.32; 7.24), and
lowest in patients without HF or LVSD (1.54; 5.27); each comparison P<0.0001. Each
outcome was less frequent in patients treated with apixaban: in all ARISTOTLE
patients, the apixaban/warfarin hazard ratio for SSE or death was 0.89 (95%
confidence interval, 0.81-0.98; P=0.02); for SSE, major bleed, or death it was 0.85
(0.78-0.92; P<0.001). There was no heterogeneity of treatment effect across the 3
groups. CONCLUSIONS: Patients with LVSD (with/without HF) had a higher risk of SSE
or death (but similar rate of SSE) compared with patients with HF but preserved LV
systolic function; both had a greater risk than patients without either HF or LVSD.
Apixaban reduced the risk of both outcomes more than warfarin in all 3 patient
groups. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique
identifier: NCT00412984.
AD - BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland,
United Kingdom. john.mcmurray@glasgow.ac.uk
AN - 23575255
AU - McMurray, J. J.
AU - Ezekowitz, J. A.
AU - Lewis, B. S.
AU - Gersh, B. J.
AU - van Diepen, S.
AU - Amerena, J.
AU - Bartunek, J.
AU - Commerford, P.
AU - Oh, B. H.
AU - Harjola, V. P.
AU - Al-Khatib, S. M.
AU - Hanna, M.
AU - Alexander, J. H.
AU - Lopes, R. D.
AU - Wojdyla, D. M.
AU - Wallentin, L.
AU - Granger, C. B.
DA - May
DO - 10.1161/circheartfailure.112.000143
DP - NLM
ET - 2013/04/12
IS - 3
J2 - Circulation. Heart failure
KW - Aged
Atrial Fibrillation/drug therapy/*epidemiology
Comorbidity
Embolism/*epidemiology/prevention & control
Female
Heart Failure/*epidemiology/physiopathology
Humans
Male
Middle Aged
Pyrazoles/therapeutic use
Pyridones/therapeutic use
Risk Assessment
Ventricular Dysfunction, Left/*epidemiology
atrial fibrillation
heart failure
left ventricular systolic dysfunction
stroke
LA - eng
N1 - 1941-3297
McMurray, John J V
Ezekowitz, Justin A
Lewis, Basil S
Gersh, Bernard J
van Diepen, Sean
Amerena, John
Bartunek, Jozef
Commerford, Patrick
Oh, Byung-Hee
Harjola, Veli-Pekka
Al-Khatib, Sana M
Hanna, Michael
Alexander, John H
Lopes, Renato D
Wojdyla, Daniel M
Wallentin, Lars
Granger, Christopher B
ARISTOTLE Committees and Investigators
Journal Article
United States
Circ Heart Fail. 2013 May;6(3):451-60. doi: 10.1161/CIRCHEARTFAILURE.112.000143.
Epub 2013 Apr 10.
PY - 2013
SN - 1941-3289
SP - 451-60
ST - Left ventricular systolic dysfunction, heart failure, and the risk of stroke
and systemic embolism in patients with atrial fibrillation: insights from the
ARISTOTLE trial
T2 - Circ Heart Fail
TI - Left ventricular systolic dysfunction, heart failure, and the risk of stroke
and systemic embolism in patients with atrial fibrillation: insights from the
ARISTOTLE trial
VL - 6
ID - 2386
ER -
TY - JOUR
AB - We aimed to assess the association between measures of obesity and outcomes
in coronary artery disease (CAD) patients. We included consecutive patients
referred to cardiac rehabilitation for previous CAD events, who were classified
using body mass index (BMI) groups and gender-specific tertiles of waist-to-hip
ratio (WHR). Follow-up was ascertained using a population-based, record linkage
system. Major cardiovascular event (MACE) was defined as the composite outcome
including acute coronary syndromes, coronary revascularization, ventricular
arrhythmias, stroke, or death from any cause. We used Cox proportional hazards
models adjusted for potential confounders. The cohort included 1,529 patients (74%
men), 63.1 ± 12.5 years (mean age ± SD), of whom 40% were obese by BMI. Eighty-
eight percent of men and 57% of women were classified as having central obesity by
WHR. Median follow-up was 5.7 years and 415 patients had MACE. After adjustment, a
high WHR tertile was a significant predictor for MACE in women (hazard ratio [HR]
1.85, 95% confidence interval [CI] 1.16, 2.94, p = 0.01) but not in men (HR 0.92,
95% CI 0.69, 1.22, p = 0.54). This relation in women persisted after further
adjustment for BMI (HR 1.75, 95% CI 1.07, 2.87, p = 0.03). Obesity by BMI was not
associated with MACE in either men (HR 1.07, 95% CI 0.76, 1.51, p = 0.69) or women
(HR 0.98, 95% CI 0.62, 1.56, p = 0.95). In conclusion, WHR is associated with a
higher risk of MACE among women with CAD but not in men. There was no obesity
paradox when assessing obesity by BMI in patients with CAD when including nonfatal
events.
AD - Division of Preventive Cardiology, Department of Cardiovascular Medicine,
Section of General Internal Medicine, Dartmouth-Hitchcock Medical Center, Geisel
School of Medicine at Dartmouth, and The Dartmouth Institute for Health Policy &
Clinical Practice, Dartmouth College, Lebanon, New Hampshire.
Division of Preventive Cardiology, Department of Cardiovascular Medicine, Mayo
Clinic, Rochester, Minnesota; Department of Physical Medicine and Rehabilitation,
Gregorio Marañón General University Hospital, Gregorio Marañón Health Research
Institute, Madrid, Spain.
Division of Health Science Research, Mayo Clinic, Rochester, Minnesota.
Division of Preventive Cardiology, Department of Cardiovascular Medicine, Mayo
Clinic, Rochester, Minnesota. Electronic address: Lopez@mayo.edu.
AN - 29482851
AU - Medina-Inojosa, J. R.
AU - Batsis, J. A.
AU - Supervia, M.
AU - Somers, V. K.
AU - Thomas, R. J.
AU - Jenkins, S.
AU - Grimes, C.
AU - Lopez-Jimenez, F.
C2 - PMC6053270
C6 - NIHMS946017
DA - Apr 15
DO - 10.1016/j.amjcard.2017.12.038
DP - NLM
ET - 2018/02/28
IS - 8
KW - Acute Coronary Syndrome/*epidemiology
Aged
Arrhythmias, Cardiac/*epidemiology
Body Mass Index
Cardiac Rehabilitation
Cardiovascular Diseases/epidemiology
Coronary Artery Disease/*epidemiology/rehabilitation
Female
Humans
Male
Middle Aged
*Mortality
Myocardial Revascularization/*statistics & numerical data
Obesity/epidemiology
Obesity, Abdominal/*epidemiology
Risk Factors
Sex Factors
*Waist-Hip Ratio
LA - eng
N1 - 1879-1913
Medina-Inojosa, Jose R
Batsis, John A
Supervia, Marta
Somers, Virend K
Thomas, Randal J
Jenkins, Sarah
Grimes, Chassidy
Lopez-Jimenez, Francisco
U48 DP005018/DP/NCCDPHP CDC HHS/United States
U48DP005018/ACL HHS/United States
Journal Article
2018 Feb 2.
PY - 2018
SN - 0002-9149 (Print)
0002-9149
SP - 903-909
ST - Relation of Waist-Hip Ratio to Long-Term Cardiovascular Events in Patients
With Coronary Artery Disease
T2 - Am J Cardiol
TI - Relation of Waist-Hip Ratio to Long-Term Cardiovascular Events in Patients
With Coronary Artery Disease
VL - 121
ID - 2424
ER -
TY - CHAP
A2 - Adam, M. P.
A2 - Ardinger, H. H.
A2 - Pagon, R. A.
A2 - Wallace, S. E.
A2 - Bean, L. J. H.
A2 - Stephens, K.
A2 - Amemiya, A.
AB - CLINICAL CHARACTERISTICS: Fabry disease results from deficient activity of
the enzyme alpha-galactosidase A (α-Gal A) and progressive lysosomal deposition of
globotriaosylceramide (GL-3) in cells throughout the body. The classic form,
occurring in males with less than 1% α-Gal A enzyme activity, usually has its onset
in childhood or adolescence with periodic crises of severe pain in the extremities
(acroparesthesia), the appearance of vascular cutaneous lesions (angiokeratomas),
sweating abnormalities (anhidrosis, hypohidrosis, and rarely hyperhidrosis),
characteristic corneal and lenticular opacities, and proteinuria. Gradual
deterioration of renal function to end-stage renal disease (ESRD) usually occurs in
men in the third to fifth decade. In middle age, most males successfully treated
for ESRD develop cardiac and/or cerebrovascular disease, a major cause of morbidity
and mortality. Heterozygous females typically have milder symptoms at a later age
of onset than males. Rarely, they may be relatively asymptomatic throughout a
normal life span or may have symptoms as severe as those observed in males with the
classic phenotype. In contrast, males with greater than 1% α-Gal A activity may
have: (1) a cardiac variant phenotype that usually presents in the sixth to eighth
decade with left ventricular hypertrophy, cardiomyopathy and arrhythmia, and
proteinuria, but without ESRD; or (2) a renal variant phenotype, associated with
ESRD but without the skin lesions or pain; or (3) cerebrovascular disease
presenting as stroke or transient ischemic attack. DIAGNOSIS/TESTING:
Identification of deficient α-Gal A enzyme activity in plasma, isolated leukocytes,
and/or cultured cells is the most efficient and reliable method of diagnosing Fabry
disease in males. Identification of a hemizygous GLA pathogenic variant by
molecular genetic testing confirms the diagnosis in a male proband. Identification
of a heterozygous GLA pathogenic variant by molecular genetic testing confirms the
diagnosis in a heterozygous female. MANAGEMENT: Treatment of manifestations:
Diphenylhydantoin, carbamazepine, or gabapentin to reduce pain (acroparesthesia);
ACE inhibitors or angiotensin receptor blockers to reduce proteinuria; chronic
hemodialysis and/or renal transplantation for ESRD. Prevention of primary
complications: The role of enzyme replacement therapy (ERT) in the long-term
prophylaxis of renal, cardiac, and CNS manifestations is unproven; however, experts
recommend that ERT be initiated as early as possible in all males with Fabry
disease (including children and those with ESRD undergoing dialysis and renal
transplantation) and in females with significant disease because all are at high
risk for cardiac, cerebrovascular, and renal complications. Prevention of secondary
complications: Prophylaxis for renovascular disease, ischemic heart disease, and
cerebrovascular disease as for the general population. Surveillance: Annual or more
frequent assessment of renal function; annual cardiology and audiology evaluations;
biennial brain MRI/MRA. Agents/circumstances to avoid: Smoking. Evaluation of
relatives at risk: Early identification of affected relatives by molecular genetic
testing if the pathogenic variant in the family is known in order to initiate ERT
as early as possible in affected individuals. GENETIC COUNSELING: Fabry disease is
inherited in an X-linked manner. In a family with more than one affected
individual, the mother of an affected male is an obligate heterozygote (carrier).
If only one male in a family is affected, his mother is likely heterozygous;
rarely, a single affected male in a family may have a de novo pathogenic variant. A
heterozygous female has a 50% chance of transmitting the GLA pathogenic variant in
each pregnancy. An affected male transmits his pathogenic variant to all of his
daughters. Heterozygote (carrier) testing for at-risk relatives and prenatal
testing for pregnancies at increased risk are possible if the pathogenic variant in
a family is known.
AD - Director, Lysosomal Storage Disorders Unit, Consultant Haematologist, Royal
Free Hospital, University College London School of Medicine, London, United Kingdom
Senior Lecturer Haematology, Lysosomal Storage Disorders Unit, Department of
Haematology, Royal Free Hospital, University College London, London, United Kingdom
AN - 20301469
AU - Mehta, A.
AU - Hughes, D. A.
CY - Seattle (WA)
LA - eng
N1 - Adam, Margaret P
Ardinger, Holly H
Pagon, Roberta A
Wallace, Stephanie E
Bean, Lora JH
Stephens, Karen
Amemiya, Anne
Mehta, Atul
Hughes, Derralynn A
Review
Book Chapter
NBK1292 [bookaccession]
PB - University of Washington, Seattle
Copyright © 1993-2020, University of Washington, Seattle. GeneReviews is a
registered trademark of the University of Washington, Seattle. All rights reserved.
PY - 1993
ST - Fabry Disease
T2 - GeneReviews(®)
TI - Fabry Disease
ID - 3141
ER -
TY - JOUR
AB - Virtually all modalities of anticoagulation play a role in cardiology. For
primary prevention, aspirin showed no effect in a British study, but reduced the
incidence of myocardial infarction by 44% per year in an American trial concerning
men and by 32% concerning women. In patients with pre-existing coronary artery
disease, the effect was even more marked. For unstable angina, several regimens
were tested. Aspirin and heparin were the drugs most frequently used, either as
single therapy or combined. They both proved efficacious, and so did ticlopidine.
Promising results were also obtained with hirudin, a specific thrombin antagonist.
For the treatment of acute infarction, the roles of aspirin and vitamin-K
antagonists are soundly established. Aspirin reduces not only mortality but also
other cardiac events. Coumadin has an even more impressive record. It reduces
mortality by 25 to 35% and recurrent infarctions by 50%, with an acceptable risk
for cerebral hemorrhage (1 to 2% per year). After coronary revascularization,
aspirin is the therapy of choice for both coronary angioplasty and bypass surgery,
with a few exceptions (poor left-ventricular function, stents in small arteries,
etc.). Ticlopidine seems to be a valid alternative. Artificial heart valves require
coumadin, with the exception of bioprosthesis in patients without additional risk
factors. The same holds true for atrial fibrillation, except for the lone variety
in young patients. Every cardiologist has to be cognizant of the armamentarium of
anticoagulants and thoroughly trained in their indications and handling.
AD - Departement Medizin, Inselspital, Bern.
AN - 7482377
AU - Meier, B.
DA - Oct
DP - NLM
ET - 1995/10/01
IS - 10
J2 - Therapeutische Umschau. Revue therapeutique
KW - Adult
Aged
Aged, 80 and over
Angina Pectoris/prevention & control
Coronary Disease/*prevention & control
Female
Humans
Male
Middle Aged
Myocardial Revascularization
LA - ger
N1 - Meier, B
English Abstract
Journal Article
Review
Switzerland
Ther Umsch. 1995 Oct;52(10):661-71.
OP - Blutverdünnung bei Herzpatienten.
PY - 1995
SN - 0040-5930 (Print)
0040-5930
SP - 661-71
ST - [Blood thinning in heart patients]
T2 - Ther Umsch
TI - [Blood thinning in heart patients]
VL - 52
ID - 3040
ER -
TY - JOUR
AB - Atrial fibrillation (AF) occurs in 0.9% of the population, in 6% of persons
over 65 and in 10% of persons over 80. It is an important independent risk factor
for thromboembolism, especially cerebral infarctions. The functions of the
atrioventricular (AV) node are: (a) optimal adjustment of the time between the
contractions of atria and ventricles; (b) protection of the ventricles against
excessively high frequencies of atrial tachycardia; (c) a pacemaker function in
case of atrial arrest. AF is an irregular, disorganized electrical activity of the
atria. On the ECG, P waves are absent and the baseline shows wavelets constantly
changing in shape, duration, amplitude and direction. Development and existence of
AF are correlated with a sufficiently large number of myocardial cells and a
sufficient degree of difference between the electrical properties of the myocardial
cells. In the absence of an AV conduction block, the resulting ventricular rhythm
is completely irregular. The constant irregularity of the ventricular rhythm is
independent of ventricular frequency and independent of cardiac and other
characteristics of the patient. Electrical stimulation of the right ventricle leads
to complete AV block.
AD - Hart-Long Instituut, Academisch Ziekenhuis, Universiteit Utrecht.
AN - 10396334
AU - Meijler, F. L.
AU - Jalife, J.
DA - Jun 12
DP - NLM
ET - 1999/07/09
IS - 24
KW - Adult
Aged
Aged, 80 and over
Atrial Fibrillation/complications/*diagnosis/*physiopathology
Atrial Function
Atrioventricular Node/*physiopathology
Electrocardiography
Electrophysiology
Female
Heart/physiology
Heart Block/physiopathology
Humans
Male
Middle Aged
Ventricular Dysfunction/*physiopathology
Ventricular Premature Complexes/physiopathology
LA - dut
N1 - Meijler, F L
Jalife, J
English Abstract
Journal Article
Review
Netherlands
Ned Tijdschr Geneeskd. 1999 Jun 12;143(24):1245-52.
OP - Elektrofysiologie van de atrioventriculaire knoop tijdens atriumfibrilleren.
I. Het kamerritme.
PY - 1999
SN - 0028-2162 (Print)
0028-2162
SP - 1245-52
ST - [Electrophysiology of the atrioventricular node during atrial fibrillation.
I. Ventricular rhythm]
TI - [Electrophysiology of the atrioventricular node during atrial fibrillation.
I. Ventricular rhythm]
VL - 143
ID - 2723
ER -
TY - JOUR
AB - OBJECTIVES: The aim of this study was to assess the role of transesophageal
echocardiography in detecting the source of cerebral embolism in ischemic stroke
patients and to evaluate the difference in occurrence of heart abnormalities in
anterior and posterior circulation infarcts. MATERIAL AND METHODS: The study group
included 104 patients, 51 males and 53 females with ischemic stroke without
significant atherosclerosis in the carotid arteries. Age of the patients ranged
from 14 to 82 years (mean 55). The clinical picture of stroke suggested the embolic
etiology, 34 of them had atrial fibrillation. Transthoracic and transesophageal
echocardiography were performed in all patients. All patients were separated as
anterior or posterior circulation infarcts. The control group consisted of 100
patients aged from 14 to 73 years (mean 53) without stroke history. RESULTS:
Transesophageal echocardiography (TEE) examination revealed left atrial thrombus in
12%, left atrial spontaneous contrast in 16%, interatrial communication in 31%,
mitral valve prolapse in 20%, atrial septal aneurysm in 14%, ventricular thrombus
in 6% and aortic atheromas of 5 mm or more in size in 7% of stroke patients. In the
control group left atrial spontaneous contrast was found in 10%, interatrial
communication in 17%, mitral valve prolapse in 4%, atrial septal aneurysm in 8%,
neither atrial nor ventricular thrombi were found. At least one abnormal TEE
finding was present in 70 (67%) of stroke patients. Abnormal TEE findings were more
often seen in patients with anterior circulation infarct than in those with
posterior circulation infarcts, although the difference was not statistically
significant. Left atrial thrombus and mitral valve prolapse occurred statistically
significantly more often in stroke patients than in the control group. CONCLUSIONS:
Echocardiographic examination is often abnormal in patients with ischemic stroke.
The study did not reveal the statistically significant difference in the prevalence
of abnormal transesophageal echocardiography findings between patients with
anterior and posterior circulation infarcts.
AD - Institute of Psychiatry and Neurology, 2nd Department of Neurology, Warsaw,
Poland.
AN - 9482680
AU - Mendel, T.
AU - Pasierski, T.
AU - Szwed, H.
AU - Barańska-Gieruszczak, M.
AU - Członkowska, A.
DA - Jan
DO - 10.1111/j.1600-0404.1998.tb00610.x
DP - NLM
ET - 1998/03/03
IS - 1
KW - Adolescent
Adult
Aged
Aged, 80 and over
Aortic Diseases/complications
Carotid Arteries/pathology
Cerebral Infarction/*diagnosis/etiology
Cerebrovascular Disorders/*diagnosis/etiology
Female
Humans
Intracranial Embolism and Thrombosis/complications/*diagnosis
Male
Middle Aged
LA - eng
N1 - Mendel, T
Pasierski, T
Szwed, H
Barańska-Gieruszczak, M
Członkowska, A
Journal Article
Denmark
Acta Neurol Scand. 1998 Jan;97(1):63-7. doi: 10.1111/j.1600-0404.1998.tb00610.x.
PY - 1998
SN - 0001-6314 (Print)
0001-6314
SP - 63-7
ST - Transesophageal echocardiographic findings in patients with anterior and
posterior circulation infarcts
TI - Transesophageal echocardiographic findings in patients with anterior and
posterior circulation infarcts
VL - 97
ID - 2782
ER -
TY - JOUR
AB - Patients with atrial fibrillation (AF) who underwent percutaneous coronary
intervention (PCI) are at elevated risk for bleeding and thromboembolic ischemic
events. Currently, guidelines on antithrombotic treatment for these patients are
based on weak consensus. We describe patterns and determinants of antithrombotic
prescriptions in this population. The Antithrombotic Strategy Variability in Atrial
Fibrillation and Obstructive Coronary Disease Revascularized with PCI Registry was
an international observational study of 859 consecutive patients with AF who
underwent PCI from 2009 to 2011. Patients were stratified by treatment at discharge
with either dual antiplatelet therapy (DAPT; aspirin plus clopidogrel) or triple
therapy (TT; warfarin plus DAPT). Bleeding and thromboembolism risks were assessed
by the HAS-BLED and CHADS2 scores, respectively, and predictors of TT prescription
at discharge were identified. Major adverse cardiovascular events and clinically
relevant bleeding (Bleeding Academic Research Consortium score ≥2) at 1-year
follow-up were compared across antithrombotic regimens. Compared with patients on
DAPT (n = 488; 57%), those given TT (n = 371; 43%) were older, with higher CHADS2
scores, lower left ventricular ejection fraction, and more often had permanent AF,
single-vessel coronary artery disease, and bare-metal stents. In multivariate
analysis, increasing thromboembolic risk (CHADS2) was associated with a higher rate
of TT prescription at discharge (intermediate vs low CHADS2: odds ratio 2.2, 95%
confidence interval [CI] 2.0 to 3.3, p <0.01; high vs low CHADS2: odds ratio 1.6,
95% CI 2.6 to 4.3, p <0.01 for TT). However, there was no significant association
between bleeding risk and TT prescription in the overall cohort or within each
CHADS2 risk stratum. The rates of major adverse cardiovascular events were similar
for patients discharged on TT or DAPT (20% vs 17%, adjusted hazard ratio 0.8, 95%
CI 0.5 to 1.1, p = 0.19), whereas the rate of Bleeding Academic Research Consortium
≥2 bleeding was higher in patients discharged on TT (11.5% vs 6.4%, adjusted hazard
ratio 1.8, 95% CI 1.1 to 2.9, p = 0.02). In conclusion, the choice of the intensity
of antithrombotic therapy correlated more closely with the risk of ischemic rather
than bleeding events in this cohort of patients with AF who underwent PCI.
AD - The Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai Heart,
Mount Sinai Medical Center, New York, New York; Cardiovascular Department,
University of Milan, Humanitas Research Hospital, Rozzano, Milan, Italy.
The Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai Heart, Mount
Sinai Medical Center, New York, New York.
Sinai Medical Center, New York, New York; Division of Cardiology, University of
Catania, Ospedale Ferrarotto, Catania, Italy.
Catheterization Lab and Interventional Cardiology Unit, San Raffaele Hospital,
Milan, Italy.
Cardiovascular Department, University of Milan, Humanitas Research Hospital,
Rozzano, Milan, Italy.
Division of Cardiology, University of Catania, Ospedale Ferrarotto, Catania, Italy.
Sinai Medical Center, New York, New York. Electronic address:
roxana.mehran@mountsinai.org.
AN - 25956624
AU - Mennuni, M. G.
AU - Bansilal, S.
AU - Schoos, M. M.
AU - Theodoropoulos, K. N.
AU - Meelu, O. A.
AU - Sartori, S.
AU - Giacoppo, D.
AU - Bernelli, C.
AU - Moreno, P. R.
AU - Krishnan, P.
AU - Baber, U.
AU - Lucarelli, C.
AU - Dangas, G. D.
AU - Sharma, S. K.
AU - Kini, A. S.
AU - Tamburino, C.
AU - Chieffo, A.
AU - Colombo, A.
AU - Presbitero, P.
AU - Mehran, R.
DA - Jul 1
DO - 10.1016/j.amjcard.2015.03.033
DP - NLM
ET - 2015/05/10
IS - 1
KW - Aged
Aged, 80 and over
Anticoagulants/administration & dosage/*adverse effects
Atrial Fibrillation/drug therapy/*mortality/*surgery
*Blood Loss, Surgical/prevention & control
Cohort Studies
Female
Humans
Incidence
Italy
Male
Middle Aged
*Percutaneous Coronary Intervention/adverse effects/mortality
Risk Assessment
Risk Factors
Sicily
Stents
Stroke/*mortality
Treatment Outcome
United States
LA - eng
N1 - 1879-1913
Mennuni, Marco G
Bansilal, Sameer
Schoos, Mikkel M
Theodoropoulos, Kleanthis N
Meelu, Omar A
Sartori, Samantha
Giacoppo, Daniele
Bernelli, Chiara
Moreno, Pedro R
Krishnan, Prakash
Baber, Usman
Lucarelli, Carla
Dangas, George D
Sharma, Samin K
Kini, Annapoorna S
Tamburino, Corrado
Chieffo, Alaide
Colombo, Antonio
Presbitero, Patrizia
Mehran, Roxana
Journal Article
Multicenter Study
Observational Study
United States
2015 Apr 8.
PY - 2015
SN - 0002-9149
SP - 37-42
ST - Balancing the Risk of Bleeding and Stroke in Patients With Atrial
Fibrillation After Percutaneous Coronary Intervention (from the AVIATOR Registry)
T2 - Am J Cardiol
TI - Balancing the Risk of Bleeding and Stroke in Patients With Atrial
Fibrillation After Percutaneous Coronary Intervention (from the AVIATOR Registry)
VL - 116
ID - 2423
ER -
TY - JOUR
AB - The construction and electrochemical response characteristics of polyvinyl
chloride (PVC) membrane sensors for determination of tiapride in presence of its
degradation products are described. The sensors are based on the ion association
complexes of tiapride cation with sodium tetraphenyl borate (Tia-TPB) [sensor 1])
or ammonium reineckate (Tia-R) [sensor 2] counter anions as ion exchange sites in
PVC matrix. The performance characteristics, sensitivity and selectivity of these
electrodes in presence of tiapride degradation products were evaluated according to
IUPAC recommendations. It reveals a fast, stable and linear response for tiapride
over the concentration range 10(-5)-10(-2) M with cationic slopes of 28.997 and
30.580 mV per concentration decade with sensors 1 and 2, respectively. These
sensors exhibit fast response time (20-30 s), low quantitation limit (4.5x10(-6)
and 3.6x10(-6), respectively), and good stability (6-8 weeks). The direct
potentiometric determination of tiapride hydrochloride using the proposed sensors
gave average recoveries of 99.95+/-0.678 and 99.92+/-1.157 for sensors 1 and 2,
respectively. The sensors are used for determination of tiapride hydrochloride, in
pure form, in presence of its degradation products in tablets, and in plasma.
Validation of the method shows suitability of the proposed sensors for use in the
quality control assessment of tiapride hydrochloride and for routine analysis as
stability indicating method. The developed method was found to be simple, accurate
and precise when compared with a reference company spectrophotometric method.
AD - Analytical Chemistry Department, Faculty of Pharmacy, Cairo University,
Egypt. fadiahm@yahoo.com
AN - 17666880
AU - Metwally, F. H.
DA - Aug
DO - 10.1248/yakushi.127.1267
DP - NLM
ET - 2007/08/02
IS - 8
J2 - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
KW - Anti-Dyskinesia Agents/*analysis/blood
Drug Stability
*Ion-Selective Electrodes
*Membranes, Artificial
Polyvinyl Chloride
Tablets/chemistry
Tiapamil Hydrochloride/*analysis/blood
LA - eng
N1 - Metwally, Fadia Hussein
Journal Article
Japan
Yakugaku Zasshi. 2007 Aug;127(8):1267-73. doi: 10.1248/yakushi.127.1267.
PY - 2007
SN - 0031-6903 (Print)
0031-6903
SP - 1267-73
ST - Membrane sensors for the selective determination of tiapride in presence of
its degradation products
T2 - Yakugaku Zasshi
TI - Membrane sensors for the selective determination of tiapride in presence of
its degradation products
VL - 127
ID - 3060
ER -
TY - JOUR
AB - INTRODUCTION: A number of large-scale retrospective studies revealed that
off-pump coronary artery bypass (OPCAB) was superior to on-pump coronary artery
bypass (ONCAB). The aim of the study was to investigate risk factors for mortality
when OPCAB is converted to ONCAB. METHODS: Patients who underwent OPCAB conversion
to ONCAB at the Beijing Anzhen Hospital between January 2003 and January 2013 were
assigned to the non-survivor and survivor groups. Background demographics, illness
history and preoperative, intraoperative and postoperative variables were compared.
RESULTS: Of the 247 cases, 15.4% of the patients died. Patients in the non-survivor
group were older and more frequently had diabetes mellitus (DM), arrhythmia,
myocardial infarction (MI) in the past 30 days (all p<0.05) and MI combined with
mitral regurgitation (p<0.0001); they more frequently had bigger left ventricular
end-diastolic dimension (p=0.0019), greater fall in blood pressure, ventricular
fibrillation for longer periods, longer conversion time and bypass graft occlusion.
All patients in the non-survivor group received intra-aortic balloon pump compared
to 89.5% in the survivor group and extracorporeal membrane oxygenation was more
common. Left main coronary artery disease (OR=4.431, 95%CI: 2.440-8.048, p<0.0001),
blood pressure decline ⩽40 mmHg (OR=0.509, 95%CI: 0.447-0.580, p<0.0001) and time
for conversion to ONCAB ⩾20 min were independently associated with mortality.
Rates of postoperative complications, such as renal failure, cerebral infarction or
hemorrhage, MI and redo sternotomy, were higher in the non-survivor group.
CONCLUSIONS: Conversion from OPCAB to ONCAB is associated with high mortality. Risk
factors include left main artery disease and duration of blood pressure decline >40
min.
AD - Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical
University, No. 2 Anding Road, Chaoyang District, Beijing 100029, China.
AN - 28425317
AU - Miao, N.
AU - Yang, F.
AU - Du, Z.
AU - Jiang, C.
AU - Hao, X.
AU - Wang, J.
AU - Jiang, Y.
AU - Yang, X.
AU - Xie, H.
AU - Hou, X.
DA - Oct
DO - 10.1177/0267659117705193
DP - NLM
ET - 2017/04/21
IS - 7
J2 - Perfusion
KW - Aged
Coronary Artery Bypass/*methods/mortality
Coronary Artery Bypass, Off-Pump/*methods/mortality
Female
Humans
Male
Middle Aged
Risk Factors
Survival Analysis
cardiopulmonary bypass
coronary artery bypass grafts
off-pump surgery
LA - eng
N1 - 1477-111x
Miao, Na
Yang, Feng
Du, Zhongtao
Jiang, Chunjing
Hao, Xing
Wang, Jinhong
Jiang, Yu
Yang, Xiaofang
Xie, Haixiu
Hou, Xiaotong
Journal Article
England
Perfusion. 2017 Oct;32(7):554-560. doi: 10.1177/0267659117705193. Epub 2017 Apr 20.
PY - 2017
SN - 0267-6591
SP - 554-560
ST - Mortality risk factors from converting off-pump coronary artery bypass to on-
pump coronary artery bypass
T2 - Perfusion
TI - Mortality risk factors from converting off-pump coronary artery bypass to on-
pump coronary artery bypass
VL - 32
ID - 3116
ER -
TY - JOUR
AB - BACKGROUND: In a trial comparing coronary-artery bypass grafting (CABG) alone
with CABG plus mitral-valve repair in patients with moderate ischemic mitral
regurgitation, we found no significant difference in the left ventricular end-
systolic volume index (LVESVI) or survival after 1 year. Concomitant mitral-valve
repair was associated with a reduced prevalence of moderate or severe mitral
regurgitation, but patients had more adverse events. We now report 2-year outcomes.
METHODS: We randomly assigned 301 patients to undergo either CABG alone or the
combined procedure. Patients were followed for 2 years for clinical and
echocardiographic outcomes. RESULTS: At 2 years, the mean (±SD) LVESVI was
41.2±20.0 ml per square meter of body-surface area in the CABG-alone group and
43.2±20.6 ml per square meter in the combined-procedure group (mean improvement
over baseline, -14.1 ml per square meter and -14.6 ml per square meter,
respectively). The rate of death was 10.6% in the CABG-alone group and 10.0% in the
combined-procedure group (hazard ratio in the combined-procedure group, 0.90; 95%
confidence interval, 0.45 to 1.83; P=0.78). There was no significant between-group
difference in the rank-based assessment of the LVESVI (including death) at 2 years
(z score, 0.38; P=0.71). The 2-year rate of moderate or severe residual mitral
regurgitation was higher in the CABG-alone group than in the combined-procedure
group (32.3% vs. 11.2%, P<0.001). Overall rates of hospital readmission and serious
adverse events were similar in the two groups, but neurologic events and
supraventricular arrhythmias remained more frequent in the combined-procedure
group. CONCLUSIONS: In patients with moderate ischemic mitral regurgitation
undergoing CABG, the addition of mitral-valve repair did not lead to significant
differences in left ventricular reverse remodeling at 2 years. Mitral-valve repair
provided a more durable correction of mitral regurgitation but did not
significantly improve survival or reduce overall adverse events or readmissions and
was associated with an early hazard of increased neurologic events and
supraventricular arrhythmias. (Funded by the National Institutes of Health and
Canadian Institutes of Health Research; ClinicalTrials.gov number, NCT00806988.).
AD - From the Department of Cardiothoracic and Vascular Surgery, Montefiore
Medical Center-Albert Einstein College of Medicine (R.E.M., J.J.D.), the
International Center for Health Outcomes and Innovation Research (InCHOIR),
Department of Population Health Science and Policy, Icahn School of Medicine at
Mount Sinai (M.K.P., A.J.M., H.L.C., E.B., J.R.O., E.G.M., L.N.G., A.C.G.), the
Division of Cardiothoracic Surgery, Department of Surgery, College of Physicians
and Surgeons, Columbia University (M.A.), and the Department of Cardiac Surgery,
Mount Sinai Health System (E.A.R., J.D.P.) - all in New York; the Division of
Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University Medical
Center, Durham, NC (P.K.S., C.A.M.); the Division of Thoracic and Cardiovascular
Surgery, University of Virginia School of Medicine, Charlottesville (G.A., S.G.B.);
the Clinical Research Unit, Division of Cardiothoracic Surgery, Emory University
School of Medicine, Atlanta (V.T.); the Department of Surgery, Division of
Cardiovascular Surgery, University of Pennsylvania School of Medicine, Philadelphia
(M.A.A., P.A.); the Division of Cardiology, Massachusetts General Hospital
(J.W.H.), and the Cardiovascular Division, Brigham and Women's Hospital (P.T.O.) -
both in Boston; Montreal Heart Institute, University of Montreal, Montreal (L.P.P.,
I.E.-H.), Peter Munk Cardiac Centre and Division of Cardiovascular Surgery, Toronto
General Hospital, University Health Network and the Division of Cardiac Surgery,
University of Toronto, Toronto (R.D.W.), and Institut Universitaire de Cardiologie
de Québec, Hôpital Laval, Quebec, QC (F.D., P.V.) - all in Canada; the Department
of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Cleveland
(A.M.G.); and the Division of Cardiovascular Sciences (M.A.M., W.C.T.-P.) and
Office of Biostatistics Research (N.J.), National Heart, Lung, and Blood Institute,
Bethesda, and the Department of Surgery, University of Maryland Medical Cent
AN - 27040451
AU - Michler, R. E.
AU - Smith, P. K.
AU - Parides, M. K.
AU - Ailawadi, G.
AU - Thourani, V.
AU - Moskowitz, A. J.
AU - Acker, M. A.
AU - Hung, J. W.
AU - Chang, H. L.
AU - Perrault, L. P.
AU - Gillinov, A. M.
AU - Argenziano, M.
AU - Bagiella, E.
AU - Overbey, J. R.
AU - Moquete, E. G.
AU - Gupta, L. N.
AU - Miller, M. A.
AU - Taddei-Peters, W. C.
AU - Jeffries, N.
AU - Weisel, R. D.
AU - Rose, E. A.
AU - Gammie, J. S.
AU - DeRose, J. J., Jr.
AU - Puskas, J. D.
AU - Dagenais, F.
AU - Burks, S. G.
AU - El-Hamamsy, I.
AU - Milano, C. A.
AU - Atluri, P.
AU - Voisine, P.
AU - O'Gara, P. T.
AU - Gelijns, A. C.
C2 - PMC4908820
C6 - NIHMS786140
DA - May 19
DO - 10.1056/NEJMoa1602003
DP - NLM
ET - 2016/04/05
IS - 20
KW - *Coronary Artery Bypass
Female
Follow-Up Studies
Humans
Length of Stay
Male
Mitral Valve/*surgery
Mitral Valve Insufficiency/etiology/mortality/*surgery
Myocardial Infarction/complications/*surgery
Patient Readmission/statistics & numerical data
Quality of Life
Stroke/etiology
Tachycardia, Supraventricular/etiology
LA - eng
N1 - 1533-4406
Michler, Robert E
Smith, Peter K
Parides, Michael K
Ailawadi, Gorav
Thourani, Vinod
Moskowitz, Alan J
Acker, Michael A
Hung, Judy W
Chang, Helena L
Perrault, Louis P
Gillinov, A Marc
Argenziano, Michael
Bagiella, Emilia
Overbey, Jessica R
Moquete, Ellen G
Gupta, Lopa N
Miller, Marissa A
Taddei-Peters, Wendy C
Jeffries, Neal
Weisel, Richard D
Rose, Eric A
Gammie, James S
DeRose, Joseph J Jr
Puskas, John D
Dagenais, François
Burks, Sandra G
El-Hamamsy, Ismail
Milano, Carmelo A
Atluri, Pavan
Voisine, Pierre
O'Gara, Patrick T
Gelijns, Annetine C
Ctsn
UM1 HL088963/HL/NHLBI NIH HHS/United States
Canadian Institutes of Health Research/Canada
Comparative Study
Journal Article
Multicenter Study
N Engl J Med. 2016 May 19;374(20):1932-41. doi: 10.1056/NEJMoa1602003. Epub 2016
Apr 3.
PY - 2016
SN - 0028-4793 (Print)
0028-4793
SP - 1932-41
ST - Two-Year Outcomes of Surgical Treatment of Moderate Ischemic Mitral
Regurgitation
T2 - N Engl J Med
TI - Two-Year Outcomes of Surgical Treatment of Moderate Ischemic Mitral
Regurgitation
VL - 374
ID - 2287
ER -
TY - JOUR
AB - Chronic myocardial infarction represents one of the most important problems
of actual clinical medicine because their incidence is growing especially at young
adults (< 45 years) and their mortality with no treatment is high in first month
after acute myocardial infarction (50%). When cardiovascular disease is associated
with diabetes mellitus, evolution of patients is more serious. AIM: To compare the
disease evolution for two groups of patients--one with patients who have purely
chronic myocardial infarction and other with patients who have chronic myocardial
infarction associated with glycoregulation disturbances (diabetes mellitus,
impaired glucose tolerance or impaired fasting glucose). MATERIAL AND METHOD: The
study group included 205 patients with chronic myocardial infarction; the study was
a retrospective analysis of the clinical and biochemical parameters of patients.
RESULTS: The patient age was between 37-89 years (the middle age was 65 years) and
the predominant environment was urban. All of the patients have chronic myocardial
infarction and 60% of them have associated glycoregulation disturbance. The
majority of hospitalised patient was symptomatic and the major symptoms where chest
pain and dyspnoea. Most patients had abdominal obesity associated with hypertension
and tachycardia. The most frequent component of metabolic syndrome was
hypertension. More patients had abnormal value of glycaemia, the expression of an
inefficient control of the diabetic disease. High level of the serum cholesterol
and triglycerides was found more frequently. Hypercholesterolemia was a predominant
expression of dyslipidemia in discordance with literature dates for diabetic
patient. A different degree of renal failure was found, frequently in patients with
glycoregulation disturbances. The electrocardiograms revealed that the majority of
patients have a complete (transmural) myocardial infarction and the most frequently
localisation was the previous one. The clinical manifestation-breathing and
ecocardiographical aspects (law value of EjF and abnormal parietal kinetic)
expression of the cardiac failure was found in 46% patients more frequently in
diabetic disease. The complication of myocardial infarction -post infarction
angina, ventricular aneurism, and arrhythmia -appears more frequently among patient
with glycoreglation disturbance. The other vascular territories affected by ATS
where cerebral arteries and peripheral arteries. CONCLUSION: This study confirms
the unfavourable evolution of myocardial infarction in diabetic patient.
AD - Facultatea de Medicină, Clinica a VI-a Medicala, Universitatea de Medicina si
Farmacie "Gr.T.Popa" Iaşi.
AN - 20191816
AU - Mihalcea, C.
AU - Pandele, G. I.
DA - Jul-Sep
DP - NLM
ET - 2010/03/03
IS - 3
J2 - Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi
KW - Adult
Aged
Aged, 80 and over
Biomarkers/blood
Chest Pain
Cholesterol/blood
Chronic Disease
Diabetes Complications/blood/*diagnosis
Diabetes Mellitus, Type 2/blood/*complications/*diagnosis
Electrocardiography
Female
Glucose Intolerance/blood/*complications/*diagnosis
Humans
Male
Middle Aged
Myocardial Infarction/blood/*complications/*diagnosis
Obesity, Abdominal/complications
Risk Factors
Tachycardia/etiology
Triglycerides/blood
LA - rum
N1 - Mihalcea, Cecilia
Pandele, G I
Comparative Study
English Abstract
Journal Article
Romania
Rev Med Chir Soc Med Nat Iasi. 2009 Jul-Sep;113(3):685-91.
OP - Infarctul de miocard la pacientul cu diabet zaharat sau cu prediabet.
PY - 2009
SN - 0048-7848 (Print)
0048-7848
SP - 685-91
ST - [Chronic miocardial infarction among patients with diabetes mellitus or
impaired glucose tolerance]
T2 - Rev Med Chir Soc Med Nat Iasi
TI - [Chronic miocardial infarction among patients with diabetes mellitus or
impaired glucose tolerance]
VL - 113
ID - 3054
ER -
TY - JOUR
AB - A 43-year-old female with old myocardial infarction and stenosed bypass
grafts developed sustained Torsades de Pointes/ventricular flutter (rate = 300-400
beats per minute) during coronary arteriography after contrast injection to the
diagonal graft. Cough-CPR (rate = 37/min) was started within 5 s of dysrhythmia
initiation and continued through two defibrillation attempts (200 and 360 joules),
and IV lidocaine was administered until return of spontaneous circulation 62 s
later. The patient never lost consciousness during this very rapid dysrhythmia.
Certain cardiac arrest resuscitation measures (namely, initial defibrillation
attemps, IV lidocaine administration) can thus be initiated in a patient while
performing cough-CPR and maintaining adequate cerebral perfusion. During the
dysrhythmia with Cough-CPR: (a) aortic systolic pressures averaged 100 mmHg--this
has commonly been observed in other reports, and (b) aortic diastolic pressures
were always > or = 50 mmHg and averaged 63 mmHg, which has seldom been this high
during cough-CPR. Dysrhythmia reversion occurred 4 s after the second
defibrillation attempt and 80 msec after the peak of the highest cough-generated
aortic pressure pulse (128 mmHg). Cough-induced ventricular tachycardia reversion
has previously been reported; this may have acted in concert with electrical
defibrillation to facilitate dysrhythmia reversion. The patient recovered without
incident.
AD - Aurora Denver Cardiology Associates, Colorado.
AN - 7989690
AU - Miller, B.
AU - Cohen, A.
AU - Serio, A.
AU - Bettock, D.
DA - Sep-Oct
DO - 10.1016/0736-4679(94)90415-4
DP - NLM
ET - 1994/09/01
IS - 5
KW - Adult
Aorta/physiopathology
Blood Pressure
*Cardiopulmonary Resuscitation/methods
Coronary Angiography/adverse effects
Cough
Electrocardiography
Female
*Hemodynamics
Humans
Lidocaine/administration & dosage
Torsades de Pointes/etiology/physiopathology/*therapy
LA - eng
N1 - Miller, B
Cohen, A
Serio, A
Bettock, D
Case Reports
Journal Article
United States
J Emerg Med. 1994 Sep-Oct;12(5):627-32. doi: 10.1016/0736-4679(94)90415-4.
PY - 1994
SN - 0736-4679 (Print)
0736-4679
SP - 627-32
ST - Hemodynamics of cough cardiopulmonary resuscitation in a patient with
sustained torsades de pointes/ventricular flutter
T2 - J Emerg Med
TI - Hemodynamics of cough cardiopulmonary resuscitation in a patient with
sustained torsades de pointes/ventricular flutter
VL - 12
ID - 2869
ER -
TY - JOUR
AB - BACKGROUND: The etiology of cerebral ischemia is undetermined in one-third of
patients upon discharge. Occult paroxysmal atrial fibrillation (PAF) is considered
a potential etiology. A high rate of PAF detection with 21-day mobile cardiac
outpatient telemetry (MCOT) has been reported in two small studies. Optimal
monitoring duration and factors predicting PAF have not been adequately defined.
METHODS: We performed a retrospective analysis on patients evaluated by MCOT
monitoring within 6 months of a cryptogenic stroke or TIA. Multivariate analysis
with survival regression methods was performed using baseline characteristics to
determine predictive risk factors for detection of PAF. Kaplan-Meier estimates were
computed for 21-day PAF rates. RESULTS: We analyzed 156 records; PAF occurred in 27
of 156 (17.3%) patients during MCOT monitoring of up to 30 days. The rate of PAF
detection significantly increased from 3.9% in the initial 48 h, to 9.2% at 7 days,
15.1% at 14 days, and 19.5% by 21 days (p<0.05). Female gender, premature atrial
complex on ECG, increased left atrial diameter, reduced left ventricular ejection
fraction and greater stroke severity were independent predictors of PAF detection
on multivariate analysis with strongest correlation seen for premature atrial
complex on ECG (HR 13.7, p=0.001). CONCLUSION: MCOT frequently detects PAF in
patients with cryptogenic stroke and TIA. Length of monitoring is strongly
associated with detection of PAF, with an optimal monitoring period of at least 21
days. Of the predictors of PAF detection, the presence of premature atrial
complexes on ECG held the strongest correlation with PAF.
AD - Henry Ford Hospital, Detroit, MI, United States. dmille12@hfhs.org
AN - 23102659
AU - Miller, D. J.
AU - Khan, M. A.
AU - Schultz, L. R.
AU - Simpson, J. R.
AU - Katramados, A. M.
AU - Russman, A. N.
AU - Mitsias, P. D.
DA - Jan 15
DO - 10.1016/j.jns.2012.10.001
DP - NLM
ET - 2012/10/30
IS - 1-2
KW - Adult
Aged
Aged, 80 and over
Arrhythmias, Cardiac/diagnosis/epidemiology
Atrial Fibrillation/*diagnosis/*etiology
Brain Ischemia/complications/diagnosis
Electrocardiography
Female
Humans
Ischemic Attack, Transient/complications/diagnosis
Male
Middle Aged
Monitoring, Ambulatory/*methods
Regression Analysis
Sex Factors
Survival Analysis
Telemetry/*methods
LA - eng
N1 - 1878-5883
Miller, Daniel J
Khan, Muhib A
Schultz, Lonni R
Simpson, Jennifer R
Katramados, Angelos M
Russman, Andrew N
Mitsias, Panayiotis D
Journal Article
Netherlands
J Neurol Sci. 2013 Jan 15;324(1-2):57-61. doi: 10.1016/j.jns.2012.10.001. Epub 2012
Oct 24.
PY - 2013
SN - 0022-510x
SP - 57-61
ST - Outpatient cardiac telemetry detects a high rate of atrial fibrillation in
cryptogenic stroke
T2 - J Neurol Sci
TI - Outpatient cardiac telemetry detects a high rate of atrial fibrillation in
cryptogenic stroke
VL - 324
ID - 2458
ER -
TY - JOUR
AB - Preoperative computed tomography( CT)-guided marking with a short hook wire
for small sized lung tumors has become popular along with the spread of
thoracoscopic surgery. Systemic arterial air embolism is a very rare but
potentially fatal complication. The patient was a 79-year-old man who was found to
have a mixed ground glass opacity shadow on chest CT. Almost immediately after
marking, he lost consciousness and complete atrio-ventricular (AV) block was found
on the electrocardiogram (ECG) monitor. Brain CT showed intravascular air bubbles
in the right frontal lobe. Two hours later, his conscious level was recovered
completely but remained left hemiplegia. Five hours later, he was transported to
another hospital for hyperbaric oxygen therapy. After 3 episodes of the treatment,
left hemiplegia recovered with slight sense disorder in the left little finger.
When neurologic findings are remained after air embolism, hyperbaric oxygen therapy
should be arranged immediately.
AD - Department of Thoracic Surgery, Tokyo Teishin Hospital, Tokyo, Japan.
AN - 22940663
AU - Mizutani, E.
AU - Nakahara, K.
AU - Miyanaga, S.
AU - Yoshiya, T.
DA - Sep
DP - NLM
ET - 2012/09/04
IS - 10
KW - Aged
Atrioventricular Block/etiology
Biopsy, Fine-Needle/*adverse effects/*methods
Embolism, Air/*etiology/*therapy
Hemiplegia/etiology/therapy
Humans
*Hyperbaric Oxygenation
Lung Neoplasms/diagnostic imaging
Male
*Tomography, X-Ray Computed
LA - jpn
N1 - Mizutani, Eiki
Nakahara, Kazuki
Miyanaga, Shigeki
Yoshiya, Tomoharu
Case Reports
Journal Article
Japan
Kyobu Geka. 2012 Sep;65(10):899-902.
PY - 2012
SN - 0021-5252 (Print)
0021-5252
SP - 899-902
ST - [Hyperbaric oxygen therapy for air embolism complicating computed tomography
(CT)-guided needle marking of the lung]
T2 - Kyobu Geka
TI - [Hyperbaric oxygen therapy for air embolism complicating computed tomography
(CT)-guided needle marking of the lung]
VL - 65
ID - 3041
ER -
TY - JOUR
AB - BACKGROUND: Atrial fibrillation (AF) is the most common arrhythmia occurring
in 2% of the population. It is known that AF increases morbidity and limits quality
of life. The CHA(2) DS(2) VASc score (congestive heart failure/left ventricular
dysfunction, hypertension, age ≥75 (doubled), diabetes, stroke (doubled), vascular
disease, age 65-74 and sex category (female)) is widely used to assess thrombotic
complications. The CHA(2) DS(2) VASc score was not used until now in predicting the
effectiveness of electrical cardioversion. AIM: To assess the value of CHA(2) DS(2)
VASc score in predicting unsuccessful electrical cardioversion. METHODS: We
analysed 258 consecutive patients with persistent AF who underwent electrical
cardioversion between January 2012 and April 2016 in a Cardiology University Centre
in Poland. RESULTS: Out of 3500 hospitalised patients with AF, 258 (mean age 64 ±
11 years, 64% men) underwent electrical cardioversion. The CHA(2) DS(2) VASc score
in analysed population (258 patients) was 2.5 ± 1.7 (range 0-8), and the HAS-BLED
(hypertension, abnormal liver or renal function, stroke, bleeding, labile
international normalised ratio, elderly, drugs or alcohol) was 1 ± 0.9 (range 0-4).
Electrical cardioversion was unsuccessful in 12%. Factors associated with
unsuccessful cardioversion were age (P = 0.0005), history of ischaemic stroke (P =
0.04), male gender (P = 0.01) and CHA(2) DS(2) VASc score (P = 0.002). The CHA(2)
DS(2) VASc score in patients who had unsuccessful cardioversion was higher compared
to patients who had successful cardioversion - 3.5 versus 2.4 (P = 0.001). In the
logistic regression model, if the CHA(2) DS(2) VASc score increases by 1, the odds
of unsuccessful cardioversion increase by 39% (odds ratio (OR) 1.39; confidence
interval (CI): 1.12-1.71; P = 0.002). The odds of unsuccessful cardioversion are
three times higher in patients with a CHA(2) DS(2) VASc score ≥ 2 than in patients
with a CHA(2) DS(2) VASc score of 0 or 1 (OR 3.06; CI: 1.03-9.09; P = 0.044).
CONCLUSION: The CHA(2) DS(2) VASc score routinely used in thromboembolic risk
assessment may be a simple, easy and reliable scoring system that can be used to
predict unsuccessful electrical cardioversion.
AD - Department of Cardiology, Medical University of Bialystok, Bialystok, Poland.
AN - 27860070
AU - Mlodawska, E.
AU - Tomaszuk-Kazberuk, A.
AU - Lopatowska, P.
AU - Kaminski, M.
AU - Musial, W. J.
DA - Mar
DO - 10.1111/imj.13319
DP - NLM
ET - 2016/11/20
IS - 3
J2 - Internal medicine journal
KW - Aged
Atrial Fibrillation/*complications/mortality
Electric Countershock/*mortality
Female
Health Status Indicators
Humans
Male
Middle Aged
Prognosis
Quality of Life
Risk Assessment
Risk Factors
Stroke/mortality/*prevention & control
Thromboembolism/*complications/mortality
CHA2DS2VASc score
atrial fibrillation
cardioversion
LA - eng
N1 - 1445-5994
Mlodawska, Elzbieta
Tomaszuk-Kazberuk, Anna
Lopatowska, Paulina
Kaminski, Marcin
Musial, Wlodzimierz J
Journal Article
Australia
Intern Med J. 2017 Mar;47(3):275-279. doi: 10.1111/imj.13319.
PY - 2017
SN - 1444-0903
SP - 275-279
ST - CHA(2) DS(2) VASc score predicts unsuccessful electrical cardioversion in
patients with persistent atrial fibrillation
T2 - Intern Med J
TI - CHA(2) DS(2) VASc score predicts unsuccessful electrical cardioversion in
patients with persistent atrial fibrillation
VL - 47
ID - 2518
ER -
TY - JOUR
AB - Introduction and Case Presentation: A 44-year-old female patient suffered
migraines and underwent contrast-enhanced transcranial Doppler (c-TCD). During the
rapid injection of contrast agent, she suffered chest tightness, palpitation,
decreased consciousness, perimouth numbness, and headache, respectively. Meanwhile,
"curtain" pattern of air embolic signals lasted up to 115 seconds in her decreased
right middle cerebral artery accompanied with arrhythmia. The microair embolic
signals lasted as long as 340 seconds. The patient's symptoms were relieved in 30
minutes. The aforementioned symptoms and signs occurred, lasted, then disappeared
coinciding in time with changes of microbubbles. The woman was later found to have
ventricular septal defect. Discussion: The adverse effects to cardiac-neurovascular
system of c-TCD are reported for the first time, which arouse attention to safety
of the procedure.
AD - Department of Comprehensive Stroke Center, The Second Affiliated Hospital of
Guangzhou University of Chinese Medicine, Guangzhou, China.
Department of Ultrasound, The Second Affiliated Hospital of Guangzhou University of
Chinese Medicine, Guangzhou, China.
Department of Comprehensive Stroke Center, The Second Affiliated Hospital of
Guangzhou University of Chinese Medicine, Guangzhou, China. Electronic address:
zhjx5988@sina.com.
AN - 31952979
AU - Mo, X.
AU - Xuan, Z.
AU - Zhang, W.
AU - Wang, W.
AU - Zhong, J.
DA - Apr
DO - 10.1016/j.jstrokecerebrovasdis.2019.104627
DP - NLM
ET - 2020/01/19
IS - 4
KW - Adult
Contrast Media/administration & dosage/*adverse effects
Embolism, Air/diagnostic imaging/*etiology/physiopathology
Female
Heart Septal Defects, Ventricular/*complications/diagnostic imaging/physiopathology
Humans
Intracranial Embolism/diagnostic imaging/*etiology/physiopathology
Microbubbles/*adverse effects
*Middle Cerebral Artery/diagnostic imaging/physiopathology
Ultrasonography, Doppler, Transcranial/*adverse effects
Transcranial Doppler
adverse effects
microbubbles
right-to-left shunt
ventricular septal defects
LA - eng
N1 - 1532-8511
Mo, Xiuyun
Xuan, Zhengzheng
Zhang, Weijun
Wang, Wei
Zhong, Jingxin
Case Reports
United States
J Stroke Cerebrovasc Dis. 2020 Apr;29(4):104627. doi:
10.1016/j.jstrokecerebrovasdis.2019.104627. Epub 2020 Jan 15.
PY - 2020
SN - 1052-3057
SP - 104627
ST - Cardiac-Neurovascular Adverse Effects Responsible to Contrast Transcranial
Doppler: A Case Report
TI - Cardiac-Neurovascular Adverse Effects Responsible to Contrast Transcranial
Doppler: A Case Report
VL - 29
ID - 3075
ER -
TY - JOUR
AB - OBJECTIVES: To explore whether the predictive power of mid-life ECG
abnormalities and conventional cardiovascular risk factors for future stroke change
over a 30-year follow-up period, and whether a repeated examination improves their
predictive power. DESIGN AND SETTING: Longitudinal population-based study.
PARTICIPANTS: 2,322 men aged 50 years, with a follow-up period of 30 years. 1,221
subjects were re-examined at age 70 years MAIN OUTCOME MEASURE: Risk for fatal and
non-fatal stroke during three decades of follow-up. Investigations included resting
ECG and traditional cardiovascular risk factors. RESULTS: When measured at age 50
years, ST segment depression and T wave abnormalities, together with ECG-left
ventricular hypertrophy, were of importance only during the first 20 years, but
regained importance when re-measured at age 70 years. Blood pressure was a
significant predictor for stroke over all three decades of follow-up. In elderly
people only, there is evidence that apolipoprotein A1 may protect from future
stroke. CONCLUSION: Mid-life values for blood pressure and ECG abnormalities retain
their predictive value over long follow-up periods even though they improved in
predictive power when re-measured in elderly people. Despite lower prevalence, ECG
abnormalities had greater impact at age 50 years than at age 70 years. By contrast,
apolipoprotein A1 was protective for future stroke only at age 70 years.
AD - Department of Public Health and Caring Sciences, Section of Geriatrics,
Uppsala Science Park, SE-751 85 Uppsala, Sweden.
christina.strom_moller@pubcare.uu.se
AN - 17630370
AU - Möller, C. S.
AU - Häggström, J.
AU - Zethelius, B.
AU - Wiberg, B.
AU - Sundström, J.
AU - Lind, L.
C2 - PMC2652998 study was conducted, CSM, JH and LL were also employed by
AstraZeneca, Research and Development, Sweden but AstraZeneca has not had any role
in the study design; in the collection, analysis and interpretation of data; in the
writing of the manuscript; or in the decision to submit the manuscript for
publication.
DA - Aug
DO - 10.1136/jech.2006.048074
DP - NLM
ET - 2007/07/17
IS - 8
J2 - Journal of epidemiology and community health
KW - Aged
Atrial Fibrillation/complications/epidemiology/physiopathology
Cardiovascular Diseases/*epidemiology/physiopathology
Humans
Incidence
Insulin/blood
Male
Middle Aged
Myocardial Ischemia/epidemiology/physiopathology
Prognosis
Risk Factors
Smoking/adverse effects/physiopathology
Sweden/epidemiology
LA - eng
N1 - 1470-2738
Möller, Christina Ström
Häggström, Jonas
Zethelius, Björn
Wiberg, Bernice
Sundström, Johan
Lind, Lars
Journal Article
J Epidemiol Community Health. 2007 Aug;61(8):704-12. doi: 10.1136/jech.2006.048074.
PY - 2007
SN - 0143-005X (Print)
0143-005x
SP - 704-12
ST - Age and follow-up time affect the prognostic value of the ECG and
conventional cardiovascular risk factors for stroke in adult men
T2 - J Epidemiol Community Health
TI - Age and follow-up time affect the prognostic value of the ECG and
conventional cardiovascular risk factors for stroke in adult men
VL - 61
ID - 2509
ER -
TY - JOUR
AB - End stage renal disease is associated with a very high risk of premature
cardiovascular death and morbidity. Early stage chronic kidney disease (CKD) is
also associated with an increased frequency of cardiovascular events and is a
common but poorly recognised and undertreated risk factor. Cardiovascular disease
in CKD can be attributed to two distinct but overlapping pathological processes,
namely atherosclerosis and arteriosclerosis. While the risk of athero-thrombotic
events such as myocardial infarction is elevated, arteriosclerosis is the
predominant pathophysiological process involving fibrosis and thickening of the
medial arterial layer. This results in increased arterial stiffness causing left
ventricular hypertrophy and fibrosis and the exposure of vulnerable vascular beds
such as the brain and kidney to high pressure fluctuations causing small vessel
disease. These pathophysiological features are manifest by a high risk of lethal
arrhythmia, congestive heart failure, myocardial infarction and stroke. Recent work
has highlighted the importance of aldosterone and disordered bone mineral
metabolism.
AD - Cardio-Renal Research Group, Department of Cardiology, Queen Elizabeth
Hospital Birmingham and University of Birmingham, Edgbaston, Birmingham B15 2TH,
UK.
AN - 23118349
AU - Moody, W. E.
AU - Edwards, N. C.
AU - Chue, C. D.
AU - Ferro, C. J.
AU - Townend, J. N.
DA - Mar
DO - 10.1136/heartjnl-2012-302818
DP - NLM
ET - 2012/11/03
IS - 6
KW - *Arterial Occlusive Diseases/diagnosis/epidemiology/etiology
Diagnostic Imaging
Disease Progression
Global Health
Humans
Incidence
Renal Insufficiency, Chronic/*complications/physiopathology
Risk Factors
LA - eng
N1 - 1468-201x
Moody, William E
Edwards, Nicola C
Chue, Colin D
Ferro, Charles J
Townend, Jonathan N
FS/11/17/28700/British Heart Foundation/United Kingdom
PB-PG-0110-21226/Department of Health/United Kingdom
PDF-2012-05-205/Department of Health/United Kingdom
PG/12/35/29403/British Heart Foundation/United Kingdom
Journal Article
Review
England
Heart. 2013 Mar;99(6):365-72. doi: 10.1136/heartjnl-2012-302818. Epub 2012 Oct 31.
PY - 2013
SN - 1355-6037
SP - 365-72
ST - Arterial disease in chronic kidney disease
T2 - Heart
TI - Arterial disease in chronic kidney disease
VL - 99
ID - 3095
ER -
TY - JOUR
AB - BACKGROUND: For decades, repeated epidemiologic observations have been made
regarding the inverse relationship between stature and cardiovascular disease,
including stroke. However, the concept has not been fully evaluated in patients
with atrial fibrillation (AF). We investigated whether patient's height is
associated with ischemic stroke in patients with nonvalvular AF and attempted to
ascertain a potential mechanism. METHODS: All 558 AF patients were enrolled: 211
patients with ischemic stroke (144 men, 68 ± 10 years) and 347 no-stroke patients
(275 men, 56 ± 11 years) as a control group. Clinical characteristics and
echocardiographic parameters were compared between the two groups. RESULTS: (1)
Stroke patients were shorter than those in the control group (164 ± 8, vs. 169 ± 8
cm, p<0.001). However, body mass index failed to predict ischemic stroke; (2) Short
stature (OR 0.93, 95% CI 0.91-0.95, p<0.001) along with left atrial (LA) anterior-
posterior diameter and diastolic mitral inflow velocity (E) to diastolic mitral
annuls velocity (E') (E/E') were independent predictor of stroke; (3) Height showed
inverse correlation with E/E' independently, even after adjusting for other
variables, including age, sex, and body weight, and comorbidities β -0.20,
p=0.003); (4) LA size showed no correlation with stature (R=-0.06, p=0.18), whereas
left ventricular size increases according to height of patients. CONCLUSIONS: Short
stature is associated with occurrence of ischemic stroke and diastolic dysfunction
in patients with AF and preserved systolic function. Height is a non-modifiable
risk factor of stroke and might be more important than obesity in Asian AF
patients, who are relatively thinner than western populations.
AD - Cardiology Division, Department of Internal Medicine, Gachon University of
Medicine and Science, Incheon, Republic of Korea; Graduate School, Yonsei
University College of Medicine, Seoul, Republic of Korea.
Department of Radiology, Research Institute of Radiological Science, Yonsei
University College of Medicine, Seoul, Republic of Korea.
Division of Cardiology, Department of Internal Medicine, Yonsei University College
of Medicine, Seoul, Republic of Korea.
Division of Cardiology, Department of Internal Medicine, Yonsei University College
of Medicine, Seoul, Republic of Korea. Electronic address: cby6908@yuhs.ac.
AN - 24814538
AU - Moon, J.
AU - Lee, H. J.
AU - Kim, Y. J.
AU - Kim, J. Y.
AU - Pak, H. N.
AU - Ha, J. W.
AU - Lee, M. H.
AU - Joung, B.
DA - Jul 1
DO - 10.1016/j.ijcard.2014.04.154
DP - NLM
ET - 2014/05/13
IS - 3
KW - Aged
Atrial Fibrillation/diagnosis/*epidemiology/physiopathology
Body Height/*physiology
Brain Ischemia/diagnosis/*epidemiology/physiopathology
Cohort Studies
Female
Humans
Male
Middle Aged
Risk Factors
Stroke/diagnosis/*epidemiology/physiopathology
Atrial fibrillation
Diastolic function
Echocardiography
Height
Stroke
LA - eng
N1 - 1874-1754
Moon, Jeonggeun
Lee, Hye-Jeong
Kim, Young Jin
Kim, Jong-Youn
Pak, Hui-Nam
Ha, Jong-Won
Lee, Moon-Hyoung
Joung, Boyoung
Journal Article
Netherlands
Int J Cardiol. 2014 Jul 1;174(3):541-4. doi: 10.1016/j.ijcard.2014.04.154. Epub
2014 Apr 21.
PY - 2014
SN - 0167-5273
SP - 541-4
ST - Short stature and ischemic stroke in nonvalvular atrial fibrillation: new
insight into the old observation
T2 - Int J Cardiol
TI - Short stature and ischemic stroke in nonvalvular atrial fibrillation: new
insight into the old observation
VL - 174
ID - 2434
ER -
TY - JOUR
AB - BACKGROUND: Therapeutic hypothermia (TH) improves survival and confers
neuroprotection in out-of-hospital cardiac arrest (OHCA), but TH is underutilized,
and regional systems of care for OHCA that include TH are needed. METHODS AND
RESULTS: The Cool It protocol has established TH as the standard of care for OHCA
across a regional network of hospitals transferring patients to a central TH-
capable hospital. Between February 2006 and August 2009, 140 OHCA patients who
remained unresponsive after return of spontaneous circulation were cooled and
rewarmed with the use of an automated, noninvasive cooling device. Three quarters
of the patients (n=107) were transferred to the TH-capable hospital from referring
network hospitals. Positive neurological outcome was defined as Cerebral
Performance Category 1 or 2 at discharge. Patients with non-ventricular
fibrillation arrest or cardiogenic shock were included, and patients with
concurrent ST-segment elevation myocardial infarction (n=68) received cardiac
intervention and cooling simultaneously. Overall survival to hospital discharge was
56%, and 92% of survivors were discharged with a positive neurological outcome.
Survival was similar in transferred and nontransferred patients. Non-ventricular
fibrillation arrest and presence of cardiogenic shock were associated strongly with
mortality, but survivors with these event characteristics had high rates of
positive neurological recovery (100% and 89%, respectively). A 20% increase in the
risk of death (95% confidence interval, 4% to 39%) was observed for every hour of
delay to initiation of cooling. CONCLUSIONS: A comprehensive TH protocol can be
integrated into a regional ST-segment elevation myocardial infarction network and
achieves broad dispersion of this essential therapy for OHCA.
AD - Minneapolis Heart Institute Foundation, 920 E 28th St, Suite 300,
Minneapolis, MN 55407, USA. michael.mooney@allina.com
AN - 21747066
AU - Mooney, M. R.
AU - Unger, B. T.
AU - Boland, L. L.
AU - Burke, M. N.
AU - Kebed, K. Y.
AU - Graham, K. J.
AU - Henry, T. D.
AU - Katsiyiannis, W. T.
AU - Satterlee, P. A.
AU - Sendelbach, S.
AU - Hodges, J. S.
AU - Parham, W. M.
DA - Jul 12
DP - NLM
ET - 2011/07/13
IS - 2
J2 - Circulation
KW - Adolescent
Adult
Aged
Aged, 80 and over
Arrhythmias, Cardiac/mortality/therapy
Humans
Hypothermia, Induced/*methods/*standards/statistics & numerical data
Male
Middle Aged
Out-of-Hospital Cardiac Arrest/*mortality/*therapy
Risk Factors
Shock, Cardiogenic/mortality/therapy
Survival Rate
LA - eng
N1 - 1524-4539
Mooney, Michael R
Unger, Barbara T
Boland, Lori L
Burke, M Nicholas
Kebed, Kalie Y
Graham, Kevin J
Henry, Timothy D
Katsiyiannis, William T
Satterlee, Paul A
Sendelbach, Sue
Hodges, James S
Parham, William M
Journal Article
United States
Circulation. 2011 Jul 12;124(2):206-14. doi: 10.1161/CIRCULATIONAHA.110.986257.
PY - 2011
SN - 0009-7322
SP - 206-14
ST - Therapeutic hypothermia after out-of-hospital cardiac arrest: evaluation of a
regional system to increase access to cooling
T2 - Circulation
TI - Therapeutic hypothermia after out-of-hospital cardiac arrest: evaluation of a
regional system to increase access to cooling
VL - 124
ID - 2879
ER -
TY - JOUR
AB - Programmed ventricular stimulation with 3 extrastimuli was performed in 36
patients with mitral valve prolapse (MVP). Among 11 patients without transient
cerebral symptoms, none had inducible ventricular tachycardia (VT) or ventricular
fibrillation (VF), whether or not nonsustained VT or ventricular premature
complexes (VPC) were present during ambulatory electrocardiographic recordings.
These patients remained well without antiarrhythmic drug therapy for 6 to 57 months
(mean 23) of follow-up. Two patients with recurrent unexplained syncope and no
documented ventricular arrhythmia during electrocardiographic monitoring also had
no inducible VT or VF. Among 20 patients with syncope or presyncope and documented
nonsustained VT or VPCs during electrocardiographic monitoring, polymorphic
nonsustained VT was induced in 8, sustained unimorphic VT in 2, and VF in 3. In 1
patient who had inducible polymorphic nonsustained VT, electrocardiographic
monitoring during syncope showed sinus rhythm. Among 3 patients with a history of
sustained VT or VF, unimorphic VT was induced in each. Patients with MVP who have
asymptomatic ventricular ectopic activity and no inducible VT may have a benign
prognosis without treatment. In patients who have transient cerebral symptoms and
documented nonsustained VT or VPCs, VT or VF is inducible in 65%, most often
polymorphic VT. It is unclear in which patients this finding is clinically
significant and in which it is a nonspecific response to programmed stimulation.
AN - 6691249
AU - Morady, F.
AU - Shen, E.
AU - Bhandari, A.
AU - Schwartz, A.
AU - Scheinman, M. M.
DA - Jan 1
DO - 10.1016/0002-9149(84)90697-0
DP - NLM
ET - 1984/01/01
IS - 1
KW - Adult
Aged
Arrhythmias, Cardiac/complications/*diagnosis
Electrocardiography
Female
Heart Arrest/complications
Heart Ventricles
Humans
Male
Middle Aged
Mitral Valve Prolapse/*complications
Syncope/complications
LA - eng
N1 - Morady, F
Shen, E
Bhandari, A
Schwartz, A
Scheinman, M M
Journal Article
United States
Am J Cardiol. 1984 Jan 1;53(1):135-8. doi: 10.1016/0002-9149(84)90697-0.
PY - 1984
SN - 0002-9149 (Print)
0002-9149
SP - 135-8
ST - Programmed ventricular stimulation in mitral valve prolapse: analysis of 36
patients
T2 - Am J Cardiol
TI - Programmed ventricular stimulation in mitral valve prolapse: analysis of 36
patients
VL - 53
ID - 2658
ER -
TY - JOUR
AB - BACKGROUND AND PURPOSE: We sought to investigate the changes in blood
pressure (BP) that occur after hospitalization of patients with different types of
acute stroke. METHODS: Twenty-four-hour ambulatory BP monitoring was performed on
days 1 and 7 after admission to the hospital in 72 patients with acute stroke (44
thromboembolic strokes, 18 lacunar infarcts, and 10 intracerebral hemorrhages) and
in 22 control patients. Stroke was categorized clinically into the above stroke
subtypes with radiological confirmation. The controls were patients admitted with a
range of acute medical problems other than stroke who were not severely ill or in
significant pain. Left ventricular hypertrophy was assessed with echocardiography.
Multiple linear regression was used to determine the effect of stroke category on
BP after adjustment for the effects of potential confounders. RESULTS: Patients
with thromboembolic and lacunar strokes had significantly higher systolic BP (SBP)
on day 1 than control subjects (mean, 8.6% and 13.2%, respectively). Diastolic BP
(DBP) was also significantly higher for patients with thromboembolic and lacunar
strokes on day 1 (mean, 11.7% and 14.6%, respectively). Patients with intracerebral
hemorrhage had SBP 9.7% and DBP 6.3% higher than control subjects on day 1, but the
results did not achieve statistical significance. By day 7 there was no significant
difference in SBP or DBP between the stroke subgroups and control subjects.
CONCLUSIONS: BP is elevated after stroke but resolves spontaneously after 7 days.
This transient elevation in BP does not appear to result solely from the stress of
hospitalization.
AD - Department of Aged Care, St George Hospital and University of New South
Wales, Kogarah, Australia.
AN - 9227691
AU - Morfis, L.
AU - Schwartz, R. S.
AU - Poulos, R.
AU - Howes, L. G.
DA - Jul
DO - 10.1161/01.str.28.7.1401
DP - NLM
ET - 1997/07/01
IS - 7
J2 - Stroke
KW - Acute Disease
Aged
*Blood Pressure
Blood Pressure Monitoring, Ambulatory
Cerebral Hemorrhage/complications/*diagnosis
Cerebral Infarction/complications/*diagnosis
Female
Hospitalization
Humans
Linear Models
Male
Middle Aged
LA - eng
N1 - Morfis, L
Schwartz, R S
Poulos, R
Howes, L G
Journal Article
United States
Stroke. 1997 Jul;28(7):1401-5. doi: 10.1161/01.str.28.7.1401.
PY - 1997
SN - 0039-2499 (Print)
0039-2499
SP - 1401-5
ST - Blood pressure changes in acute cerebral infarction and hemorrhage
T2 - Stroke
TI - Blood pressure changes in acute cerebral infarction and hemorrhage
VL - 28
ID - 2420
ER -
TY - JOUR
AB - OBJECTIVES: Increasing human and laboratory evidence suggests that post-
resuscitative brain hypothermia reduces the pathologic consequences of brain
ischemia. Using a swine model of prolonged cardiac arrest, this investigation
sought to determine whether unilateral hypothermic carotid bypass was capable of
inducing selective brain hypothermia and reducing neurohistologic damage. METHODS:
Ventricular fibrillation was induced in common swine (n = 12). After 20 minutes of
cardiopulmonary arrest (without ventilatory support or cardiopulmonary
resuscitation), systemic extracorporeal bypass was instituted to restore coronary
and cerebral perfusion, followed by restoration of normal sinus rhythm. Animals
randomized to the normal brain temperature (NBT) cohort received mechanical
ventilation and intravenous fluids for 24 hours. The selective brain hypothermia
(SBH) cohort received 12 hours of femoral/carotid bypass at 32 degrees C. The
bypass temperature was then increased one degree per hour until reaching 37 degrees
C and continued at this temperature until completion of the protocol (24 hours).
Histopathologic damage was evaluated in two areas of the hippocampus. RESULTS:
Normal sinus rhythm was restored in all animals after the systemic
(femoral/femoral) bypass was initiated. Nasal temperature (surrogate measure of
brain temperature) remained higher than 37.0 degrees C throughout the 24-hour
recovery period in the NBT animals. In the SBH cohort, right nasal temperature
dropped to the mild hypothermic range (<34 degrees C) two hours after institution
of femoral/carotid bypass. This was maintained throughout the 12-hour cooling
period without hemodynamic compromise. There was a significant improvement in the
neurohistology scores in the CA1 region of the hippocampus of the SBH treated
animals as compared with those of the NBT cohort. CONCLUSIONS: Post-resuscitative
selective brain hypothermia reduced regional ischemic brain damage in swine with
prolonged ventricular fibrillation.
AD - Department of Traumatology and Critical Care Medicine, Sapporo Medical
University School of Medicine. Sapporo, Japan.
AN - 11581076
AU - Mori, K.
AU - Itoh, Y.
AU - Saito, J.
AU - Takeyama, Y.
AU - Kurata, Y.
AU - Kaneko, M.
AU - Asai, Y.
AU - Torigoe, T.
AU - Dickson, E. W.
DA - Oct
DO - 10.1111/j.1553-2712.2001.tb01089.x
DP - NLM
ET - 2001/10/03
IS - 10
J2 - Academic emergency medicine : official journal of the Society for Academic
Emergency Medicine
KW - Animals
Body Temperature/physiology
Body Weight/physiology
Brain Ischemia/etiology/prevention & control
Carotid Arteries/surgery
Cohort Studies
Epinephrine/administration & dosage/adverse effects
Heart Arrest/complications/therapy
Humans
*Resuscitation
Swine
Vascular Surgical Procedures
Ventricular Fibrillation/complications/therapy
LA - eng
N1 - Mori, K
Itoh, Y
Saito, J
Takeyama, Y
Kurata, Y
Kaneko, M
Asai, Y
Torigoe, T
Dickson, E W
Comparative Study
Journal Article
United States
Acad Emerg Med. 2001 Oct;8(10):937-45. doi: 10.1111/j.1553-2712.2001.tb01089.x.
PY - 2001
SN - 1069-6563 (Print)
1069-6563
SP - 937-45
ST - Post-resuscitative hypothermic bypass reduces ischemic brain injury in swine
T2 - Acad Emerg Med
TI - Post-resuscitative hypothermic bypass reduces ischemic brain injury in swine
VL - 8
ID - 2979
ER -
TY - JOUR
AB - OBJECTIVES: We sought to elucidate the long-term prognostic importance of
angiographic no-reflow phenomenon after percutaneous transluminal coronary
angioplasty (PTCA) for acute myocardial infarction (AMI). BACKGROUND: Angiographic
no-reflow phenomenon, a reduced coronary antegrade flow (Thrombolysis in Myocardial
Infarction [TIMI] flow grade < or =2) without mechanical obstruction after
recanalization, predicts poor left ventricular (LV) functional recovery and
survival in the early phase of AMI. We hypothesized that angiographic no-reflow
phenomenon also predicts long-term clinical outcome. METHODS: We studied 120
consecutive patients with their first AMI treated by PTCA without flow-restricting
lesions. The patients were classified as either no-reflow (n = 30) or reflow (TIMI-
3) (n = 90) based on post-PTCA cineangiograms to follow up (5.8 +/- 1.2 years) for
cardiac death and nonfatal events. RESULTS: Patients with no-reflow had congestive
heart failure (p < 0.0001), malignant arrhythmia (p = 0.038), and cardiac death (p
= 0.002) more often than did those with reflow. Kaplan-Meier curves showed lower
cardiac survival and cardiac event-free survival (p < 0.0001) in patients with no-
reflow than in those with reflow. Multivariate analyses disclosed that no-reflow
phenomenon was an independent predictor of long-term cardiac death (relative risk
[RR] 5.25, 95% confidence interval [CI] 1.85 to 14.9, p = 0.002) and cardiac events
(RR 3.71, 95% CI 1.79 to 7.69, p = 0.0004). At follow-up, survivors with no-reflow
had higher end-diastolic and end-systolic LV volume indices and plasma brain
natriuretic peptide levels, and lower LV ejection fractions (p = 0.0002, p <
0.0001, p = 0.002, p < 0.0001, respectively) than did those with reflow, indicating
that no-reflow may be involved in LV remodeling. CONCLUSIONS: Angiographic no-
reflow phenomenon strongly predicts long-term cardiac complications after AMI;
these complications are possibly associated with LV remodeling.
AD - Department of Internal Medicine II, Nagoya University School of Medicine,
Japan. itsuro@med.nagoya-u.ac.jp
AN - 11028471
AU - Morishima, I.
AU - Sone, T.
AU - Okumura, K.
AU - Tsuboi, H.
AU - Kondo, J.
AU - Mukawa, H.
AU - Matsui, H.
AU - Toki, Y.
AU - Ito, T.
AU - Hayakawa, T.
DA - Oct
DO - 10.1016/s0735-1097(00)00865-2
DP - NLM
ET - 2000/10/12
IS - 4
KW - Adult
Aged
Aged, 80 and over
Angioplasty, Balloon, Coronary/*adverse effects/mortality
Cause of Death
Cineangiography
*Coronary Angiography/methods
Coronary Circulation/*physiology
Female
Follow-Up Studies
Humans
Japan/epidemiology
Male
Middle Aged
Myocardial Infarction/diagnostic imaging/mortality/physiopathology/*therapy
Risk Factors
Stroke Volume
Survival Rate
LA - eng
N1 - Morishima, I
Sone, T
Okumura, K
Tsuboi, H
Kondo, J
Mukawa, H
Matsui, H
Toki, Y
Ito, T
Hayakawa, T
Comparative Study
Journal Article
United States
J Am Coll Cardiol. 2000 Oct;36(4):1202-9. doi: 10.1016/s0735-1097(00)00865-2.
PY - 2000
SN - 0735-1097 (Print)
0735-1097
SP - 1202-9
ST - Angiographic no-reflow phenomenon as a predictor of adverse long-term outcome
in patients treated with percutaneous transluminal coronary angioplasty for first
TI - Angiographic no-reflow phenomenon as a predictor of adverse long-term outcome
in patients treated with percutaneous transluminal coronary angioplasty for first
VL - 36
ID - 3130
ER -
TY - JOUR
AB - Diuretics are used in first-step antihypertensive monotherapy or in
combination with adrenergic-inhibiting agents in the majority of hypertensive
patients in the United States. A 30-year experience has demonstrated that blood
pressure is lowered to as great or greater a degree with diuretics than when many
of the presently available antihypertensive drugs, including converting enzyme
inhibitors, calcium entry blockers, beta- or alpha-adrenergic inhibitors, or
centrally acting sympatholytic agents, are used. Diuretics appear to be especially
effective in the elderly and in black patients. All of the major hypertension
clinical trials upon which we base our decisions for treatment have employed
diuretics as step-1 therapy--with a reduction in morbidity and mortality. In
addition, data suggest that more effective treatment of hypertension has
contributed to the decrease of over 45% in deaths from cerebrovascular disease and
the overall reduction of cardiovascular deaths over the past 15 to 20 years in the
United States. The debate concerning the long term safety of diuretic therapy has
focused on the USA Multiple Risk Factor Intervention Trial (MRFIT) results and
several papers, suggesting that the lipid-raising or potassium-lowering properties
of diuretics may produce adverse effects. Suggestions have been made that the use
of other drugs without metabolic side effects may result in greater benefit with
less risk, especially in the management of mild hypertension where the risk of the
disease is not immediate or great. A review of the MRFIT and lipid data from long
term studies has failed to establish the 'toxicity' of diuretic agents. In
addition, recent studies have not confirmed previous observations that diuretic-
induced hypokalaemia increases ventricular ectopy or contributes to sudden death.
Although hypokalaemia should be avoided and corrected if it occurs, especially in
patients with ischaemic heart disease, in the elderly, in patients with
pretreatment ectopy or in patients on low potassium diets, the fear of this
metabolic side effect of diuretics should not deter the physician from continuing
the use of these agents both as monotherapy in most patients and as second-step
therapy with an adrenergic-inhibiting drug.
AN - 3525090
AU - Moser, M.
DO - 10.2165/00003495-198600314-00007
DP - NLM
ET - 1986/01/01
J2 - Drugs
KW - Arrhythmias, Cardiac/blood/chemically induced
Blood Glucose/metabolism
Cholesterol/blood
Diuretics/*adverse effects/therapeutic use
Humans
Hypertension/blood/*drug therapy
Hypokalemia/blood/chemically induced
Uric Acid/blood
LA - eng
N1 - Moser, M
Journal Article
Review
New Zealand
Drugs. 1986;31 Suppl 4:56-67. doi: 10.2165/00003495-198600314-00007.
PY - 1986
SN - 0012-6667 (Print)
0012-6667
SP - 56-67
ST - The diuretic dilemma and the management of mild hypertension
T2 - Drugs
TI - The diuretic dilemma and the management of mild hypertension
VL - 31 Suppl 4
ID - 2960
ER -
TY - JOUR
AB - AIM: Short-term psychological stress is associated with an immediate
physiological response and may be associated with a transiently higher risk of
cardiovascular events. The aim of this study was to determine whether brief
episodes of anger trigger the onset of acute myocardial infarction (MI), acute
coronary syndromes (ACS), ischaemic and haemorrhagic stroke, and ventricular
arrhythmia. METHODS AND RESULTS: We performed a systematic review of studies
evaluating whether outbursts of anger are associated with the short-term risk of
heart attacks, strokes, and disturbances in cardiac rhythm that occur in everyday
life. We performed a literature search of the CINAHL, Embase, PubMed, and PsycINFO
databases from January 1966 to June 2013 and reviewed the reference lists of
retrieved articles and included meeting abstracts and unpublished results from
experts in the field. Incidence rate ratios and 95% confidence intervals were
calculated with inverse-variance-weighted random-effect models. The systematic
review included nine independent case-crossover studies of anger outbursts and
MI/ACS (four studies), ischaemic stroke (two studies), ruptured intracranial
aneurysm (one study), and ventricular arrhythmia (two studies). There was evidence
of substantial heterogeneity between the studies (I(2) = 92.5% for MI/ACS and 89.8%
for ischaemic stroke). Despite the heterogeneity, all studies found that, compared
with other times, there was a higher rate of cardiovascular events in the 2h
following outbursts of anger. CONCLUSION: There is a higher risk of cardiovascular
events shortly after outbursts of anger.
AD - Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth
Israel Deaconess Medical Center, Harvard Medical School, 375 Longwood Avenue, Room
423, Boston, MA 02215, USA Department of Epidemiology, Harvard School of Public
Health, Boston, MA, USA.
Department of Internal Medicine, New York-Presbyterian Hospital/Weill Cornell
Medical Center, New York, NY, USA.
Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel
Deaconess Medical Center, Harvard Medical School, 375 Longwood Avenue, Room 423,
Boston, MA 02215, USA Department of Epidemiology, Harvard School of Public Health,
Boston, MA, USA mmittlem@bidmc.harvard.edu.
AN - 24591550
AU - Mostofsky, E.
AU - Penner, E. A.
AU - Mittleman, M. A.
C2 - PMC4043318
DA - Jun 1
DO - 10.1093/eurheartj/ehu033
DP - NLM
ET - 2014/03/05
IS - 21
KW - Acute Coronary Syndrome/*psychology
Anger/*physiology
Arrhythmias, Cardiac/*psychology
Humans
Myocardial Infarction/*psychology
Prognosis
Risk Factors
Stroke/*psychology
Anger
Cardiovascular disease
Case-crossover
Epidemiology
LA - eng
N1 - 1522-9645
Mostofsky, Elizabeth
Penner, Elizabeth Anne
Mittleman, Murray A
F32-HL120505/HL/NHLBI NIH HHS/United States
T32-HL098048/HL/NHLBI NIH HHS/United States
Journal Article
Meta-Analysis
Review
Systematic Review
Eur Heart J. 2014 Jun 1;35(21):1404-10. doi: 10.1093/eurheartj/ehu033. Epub 2014
Mar 3.
PY - 2014
SN - 0195-668X (Print)
0195-668x
SP - 1404-10
ST - Outbursts of anger as a trigger of acute cardiovascular events: a systematic
T2 - Eur Heart J
TI - Outbursts of anger as a trigger of acute cardiovascular events: a systematic
VL - 35
ID - 2395
ER -
TY - JOUR
AB - Forty three expired cases due to ruptured cerebral aneurysm were studied in
electrocardiographic alterations with special reference to other complications of
the autonomic nervous system. The cases with past history of ischemic
cardiovascular disease had been excluded. The age of the patients ranged between 23
to 79 years old (average 50.1 years old). The clinical condition of the patients
according to Hunt & Kosnik classification I in 1 case, II in 11 cases, III in 14
cases, and IV & V in 17 cases. The duration between the aneurysm rupture and
admission was within 24 hours in 16 cases, 2 to 3 days in 13 cases, 4 to 7 days in
9 cases, and 2 to 3 weeks in 5 cases. The site of ruptured aneurysms was anterior
communicating artery in 12 cases, internal carotid artery in 24 cases, and others
in 7 cases. The direct surgeries to the aneurysms were performed in 22 cases, and
not done in 21 cases. The electrocardiographic alterations were found as follows:
flat or inverted T in 19 cases, prolonged QTc in 33 cases, manifest U in 14 cases,
ST elevation or depression in 10 cases, Ta (atrial T) in 10 cases, left ventricular
hypertrophy in 8 cases, sinus tachycardia in 7 cases, sinus bradycardia in 12
cases, and arrhythmias with SVPC or VPC (supraventricular or ventricular premature
contraction), or sinus arrhythmia in 12 cases. Prolonged QTc, and flat or inverted
T were most often found in the cases with ruptured aneurysm of the anterior
communicating artery, and next in those with the internal carotid artery, and least
often in those with others.(ABSTRACT TRUNCATED AT 250 WORDS)
AN - 3489474
AU - Motomochi, M.
AU - Handa, H.
AU - Yonekawa, Y.
AU - Taki, K.
AU - Nagasawa, S.
AU - Konishi, T.
DA - Jul
DP - NLM
ET - 1986/07/01
IS - 7
J2 - No to shinkei = Brain and nerve
KW - Adult
Aged
Autonomic Nervous System/*physiopathology
Blood Pressure
Gastrointestinal Hemorrhage/physiopathology
Humans
Intracranial Aneurysm/*physiopathology
Ischemic Attack, Transient/physiopathology
Middle Aged
Rupture, Spontaneous
LA - jpn
N1 - Motomochi, M
Handa, H
Yonekawa, Y
Taki, K
Nagasawa, S
Konishi, T
English Abstract
Journal Article
Japan
No To Shinkei. 1986 Jul;38(7):677-84.
PY - 1986
SN - 0006-8969 (Print)
0006-8969
SP - 677-84
ST - [Electrocardiographic alterations in expired cases due to ruptured cerebral
aneurysm: correlation with other complications relating to the autonomic nervous
system]
T2 - No To Shinkei
TI - [Electrocardiographic alterations in expired cases due to ruptured cerebral
aneurysm: correlation with other complications relating to the autonomic nervous
system]
VL - 38
ID - 2710
ER -
TY - JOUR
AB - PURPOSE: Contributions of cerebrospinal fluid (CSF) have not been previously
taken into account in the quantification of APT CEST effects, and correction for
the dilution of CEST effects by CSF may allow for more robust measurement of CEST
signals. The objective of this study was to compare the robustness of a partial
volume (PV) correction model against a standard (4-pool) multi-pool model as far as
their ability to quantify CEST effects in healthy, normal, and pathological tissue.
METHODS: MRI data from 12 patients presenting with ischemic stroke, and 6 healthy
subjects, were retrospectively analyzed. CEST signals derived from a 4-pool model
and a PV correction model were compared for repeatability and pathological tissue
contrast. The effect of PV correction (PVC) was assessed within 3 ranges of tissue
PV estimate (PVE): high PVE voxels, low PVE voxels, and the whole slice. RESULTS:
In voxels with a high tissue PVE, PV correction did not make a significant
difference to absolute APTR* . In low PVE voxels, the PVC model exhibited a
significantly decreased ischemic core signal. The PVC measures exhibited higher
repeatability between healthy subjects (4 pools: 3.4%, PVC: 2.4%) while maintaining
a similar ischemic core CNR (0.7) to the 4-pool model. In whole slice analysis it
was found that both models exhibited similar results. CONCLUSIONS: PV correction
yielded a measure of APT effects that was more repeatable than standard 4-pool
analysis while achieving a similar CNR in pathological tissue, suggesting that PV-
corrected analysis was more robust at low values of tissue PVE.
AD - Institute of Biomedical Engineering, Department of Engineering Science,
University of Oxford, Oxford, United Kingdom.
Acute Vascular Imaging Centre, Radcliffe Department of Medicine, University of
Oxford, Oxford, United Kingdom.
Wellcome Centre for Integrative Neuroimaging, FMRIB Division, Nuffield Department
of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
AN - 31199009
AU - Msayib, Y.
AU - Harston, G. W. J.
AU - Sheerin, F.
AU - Blockley, N. P.
AU - Okell, T. W.
AU - Jezzard, P.
AU - Kennedy, J.
AU - Chappell, M. A.
C2 - PMC6771886
DA - Nov
DO - 10.1002/mrm.27872
DP - NLM
ET - 2019/06/15
IS - 5
J2 - Magnetic resonance in medicine
KW - Adult
Aged
Artifacts
Brain Ischemia/*diagnostic imaging
Female
Healthy Volunteers
Humans
Image Interpretation, Computer-Assisted/methods
Male
Prospective Studies
Stroke/*diagnostic imaging
*cest mri
*acute ischemic stroke
*amide proton transfer
*partial volume correction
*quantification
LA - eng
N1 - 1522-2594
Msayib, Y
Harston, G W J
Sheerin, F
Blockley, N P
Okell, T W
Jezzard, P
Kennedy, J
Chappell, M A
Journal Article
Observational Study
Magn Reson Med. 2019 Nov;82(5):1920-1928. doi: 10.1002/mrm.27872. Epub 2019 Jun 14.
PY - 2019
SN - 0740-3194 (Print)
0740-3194
SP - 1920-1928
ST - Partial volume correction for quantitative CEST imaging of acute ischemic
stroke
T2 - Magn Reson Med
TI - Partial volume correction for quantitative CEST imaging of acute ischemic
stroke
VL - 82
ID - 2818
ER -
TY - JOUR
AB - We report on two cases of mechanical termination of supraventricular
tachycardia by chest thump which were followed by serious complications. In a 3-
year-old boy with an otherwise normal heart, incessant supraventricular tachycardia
was converted to sinus rhythm by a single precordial thump. This, however was
followed by thrombo-embolic infarction of the left-sided middle cerebral artery. In
another case of a 9-year-old girl, recurrent episodes of supraventricular
tachycardia were associated with Ebstein anomaly of the tricuspid valve. Chest
thump was successful in terminating supraventricular tachycardia but induced a
short run of ventricular tachycardia which terminated itself and was then followed
by sinus rhythm. It is concluded that even a slight precordial thump implies
undetermined risks in the acute management of supraventricular tachycardia in
children and should therefore be abandoned in favour of other methods.
AD - Department of Paediatric Cardiology, Children's Hospital, University of
Giessen, Federal Republic of Germany.
AN - 1728536
AU - Müller, G. I.
AU - Ulmer, H. E.
AU - Bauer, J. A.
DA - Jan
DO - 10.1007/bf02073881
DP - NLM
ET - 1992/01/01
IS - 1
J2 - European journal of pediatrics
KW - Cerebral Infarction/diagnosis/*etiology
Child
Child, Preschool
Electrocardiography
Female
Heart Massage/*adverse effects
Humans
Male
Tachycardia, Sinoatrial Nodal Reentry/diagnosis/therapy
Tachycardia, Supraventricular/diagnosis/*therapy
LA - eng
N1 - Müller, G I
Ulmer, H E
Bauer, J A
Case Reports
Journal Article
Germany
Eur J Pediatr. 1992 Jan;151(1):12-4. doi: 10.1007/BF02073881.
PY - 1992
SN - 0340-6199 (Print)
0340-6199
SP - 12-4
ST - Complications of chest thump for termination of supraventricular tachycardia
in children
T2 - Eur J Pediatr
TI - Complications of chest thump for termination of supraventricular tachycardia
in children
VL - 151
ID - 2775
ER -
TY - JOUR
AB - OBJECTIVE: To assess the association between arterial lactate concentration
on admission and the duration of human ventricular fibrillation cardiac arrest, and
to what degree the arterial lactate concentration on admission is an early
predictor of functional neurological recovery in human cardiac arrest survivors.
DESIGN: Cohort study. Arterial lactate concentrations and out-of-hospital data
concerning cardiac arrest and cardiopulmonary resuscitation were collected
retrospectively according to a standardized protocol. Functional neurological
recovery was assessed prospectively at regular intervals for 6 months. SETTING:
Emergency department of an urban tertiary care hospital. PATIENTS: A total of 167
primary survivors of witnessed out-of-hospital ventricular fibrillation cardiac
arrest. MEASUREMENTS: The association between arterial lactate concentration on
admission, the duration of cardiac arrest, and functional neurological recovery was
assessed. Further, we assessed whether admission concentrations of arterial lactate
and duration of cardiac arrest can predict unfavorable functional neurological
recovery. Functional neurological recovery was measured in cerebral performance
categories (CPC). No or minimal functional impairment (CPC 1 and 2) was defined as
favorable outcome; the remaining categories (CPC 3, 4 and 5) were defined as
unfavorable functional neurological recovery. RESULTS: In 167 patients, a weak
association between total duration of cardiac arrest and admission levels of
lactate (r = 0.49, P < 0.001) could be shown. With increasing admission
concentrations of arterial lactate functional neurological recovery was more likely
to be unfavorable (OR 1.15 per mmol/l increase, 95% CI 1.04-1.27). Nevertheless,
only at very high levels of lactate (16.3 mmol/l) could unfavorable neurological
recovery be detected with 100% specificity, yielding a very low sensitivity of 16%.
CONCLUSIONS: The arterial admission lactate concentration after out-of-hospital
ventricular fibrillation cardiac arrest is a weak measure of the duration of
ischemia. High admission lactate levels are associated with severe neurological
impairment. However, this parameter has poor prognostic value for individual
estimation of the severity of subsequent functional neurological impairment.
AD - Department of Emergency Medicine, Vienna General Hospital-University of
Vienna, Medical School, Austria. marcus.muellner@univie.ac.at
AN - 9434919
AU - Müllner, M.
AU - Sterz, F.
AU - Domanovits, H.
AU - Behringer, W.
AU - Binder, M.
AU - Laggner, A. N.
DA - Nov
DO - 10.1007/s001340050470
DP - NLM
ET - 1998/01/22
IS - 11
J2 - Intensive care medicine
KW - Aged
Cohort Studies
Emergency Medical Services
Female
Heart Arrest/*blood/etiology/*therapy
Humans
Lactates/*blood
Male
Middle Aged
Nervous System Diseases/etiology
Prognosis
Resuscitation
Time Factors
Treatment Outcome
Ventricular Fibrillation/blood/*complications/therapy
LA - eng
N1 - Müllner, M
Sterz, F
Domanovits, H
Behringer, W
Binder, M
Laggner, A N
Journal Article
United States
Intensive Care Med. 1997 Nov;23(11):1138-43. doi: 10.1007/s001340050470.
PY - 1997
SN - 0342-4642 (Print)
0342-4642
SP - 1138-43
ST - The association between blood lactate concentration on admission, duration of
cardiac arrest, and functional neurological recovery in patients resuscitated from
ventricular fibrillation
T2 - Intensive Care Med
TI - The association between blood lactate concentration on admission, duration of
cardiac arrest, and functional neurological recovery in patients resuscitated from
VL - 23
ID - 2889
ER -
TY - JOUR
AN - 14182411
AU - Mundeleer, P.
DP - NLM
ET - 1964/01/01
J2 - Acta chirurgica Belgica
KW - *Blood Coagulation Disorders
*Cerebrovascular Disorders
*Hemorrhage
Humans
*Hypothermia
*Neurology
*review
LA - fre
N1 - Mundeleer, p
Journal Article
Review
England
Acta Chir Belg. 1964;Suppl 1:SUPPL 1:314-43.
OP - Complications accompagnant l'hypothermie.
PY - 1964
SN - 0001-5458 (Print)
0001-5458
SP - Suppl 1:314-43
ST - [COMPLICATIONS ACCOMPANYING HYPOTHERMIA]
T2 - Acta Chir Belg
TI - [COMPLICATIONS ACCOMPANYING HYPOTHERMIA]
VL - Suppl 1
ID - 2935
ER -
TY - JOUR
AB - The chemistry, pharmacology, pharmacokinetics, clinical efficacy, adverse
effects, and dosage and administration of anistreplase in the treatment of acute
myocardial infarction (AMI) are reviewed. Anistreplase is an acylated form of the
streptokinase-plasminogen complex. Acylation makes the complex temporarily inactive
but protects it from neutralization by plasmin inhibitors. After deacylation, which
begins immediately after injection, the streptokinase-plasminogen complex promotes
thrombolysis by speeding the conversion of plasminogen to plasmin. Like other
thrombolytic agents, anistreplase induces a systemic fibrinogenolytic state. The
plasma half-life of anistreplase, 88-112 minutes, is longer than that of the other
thrombolytic drugs marketed in the United States. Anistreplase lyses coronary
artery thrombi when given by the intracoronary or i.v. route. I.V. anistreplase is
comparable in efficacy to i.v. streptokinase but has not been directly compared
with i.v. alteplase. Anistreplase therapy in patients with AMI may help preserve
left ventricular function and prolong survival. Anistreplase is comparable in
safety to other thrombolytic drugs. Although bleeding has occurred in 4-47% of
patients treated with anistreplase, most episodes have been clinically unimportant
and have occurred at a vascular puncture site; intracranial hemorrhage has occurred
in less than 1% of patients. Cardiac arrhythmia and transient hypotension are
common after anistreplase administration. Anistreplase is easy to administer and
may be appropriate for use in patients with suspected AMI before hospital
admission. The recommended dose is 30 units i.v. given over two to five minutes.
Anistreplase is similar in efficacy and safety to other thrombolytic agents in the
treatment of AMI. The drug's ease of administration may be an important clinical
consideration.
AD - Cardiovascular Clinical Pharmacology Research Program, Case Western Reserve
University School of Medicine, Cleveland, OH.
AN - 2198125
AU - Munger, M. A.
AU - Forrence, E. A.
DA - Jul
DP - NLM
ET - 1990/07/01
IS - 7
J2 - Clinical pharmacy
KW - Acute Disease
Animals
Anistreplase
Fibrinolytic Agents/pharmacology/*therapeutic use
Humans
Myocardial Infarction/blood/*drug therapy
Plasminogen/pharmacology/*therapeutic use
Streptokinase/pharmacology/*therapeutic use
LA - eng
N1 - Munger, M A
Forrence, E A
Journal Article
Review
United States
Clin Pharm. 1990 Jul;9(7):530-40.
PY - 1990
SN - 0278-2677 (Print)
0278-2677
SP - 530-40
ST - Anistreplase: a new thrombolytic for the treatment of acute myocardial
infarction
T2 - Clin Pharm
TI - Anistreplase: a new thrombolytic for the treatment of acute myocardial
infarction
VL - 9
ID - 3121
ER -
TY - JOUR
AB - Over the last 5 years, 15 patients received ventricular assist devices (VADs)
(Group 1) and 5 received percutaneous cardiopulmonary support (CPS) (Group 2) while
in postoperative cardiogenic shock. Group 1 consisted of 8 men and 7 women ranging
in age from 22 to 73 years (average age, 55 years). Nine of these patients
underwent surgery for valve replacement, 5 for coronary artery bypass grafting, and
1 for closure of a ventricular septal rupture. The duration of VAD support ranged
from 6 h to 9 days (mean, 3.9 days). Group 2 consisted of 4 men and 1 woman ranging
in age from 49 to 68 years (average age, 57 years). One of these patients underwent
surgery for valve replacement, 1 for coronary artery bypass grafting, 2 for
replacement of a thoracic aneurysm, and 1 for left ventricular aneurysmectomy. The
duration of CPS ranged from 4 h to 8 days (mean, 2.8 days). In Group 1, 13 patients
were weaned from the VADs and 8 survived. Bleeding occurred in 5 patients, renal
failure in 4, infection in 3, cardiac failure in 4, cerebral infarction in 1,
perioperative myocardial infarction in 1, arrhythmia in 1, and ileus in 1. In Group
2, 4 patients were weaned from the CPS and 3 survived. Bleeding occurred in 3
patients, renal failure in 2, CNS injury in 2, and cardiopulmonary failure in 1.
The 8 survivors in Group 1 have been followed for 2 to 56 months (mean, 28.7
months). Five patients were in NYHA class I, 2 were in class II and 1 was in class
III.(ABSTRACT TRUNCATED AT 250 WORDS)
AD - Department of Surgery, Okayama University Medical School, Japan.
AN - 7998888
AU - Murakami, T.
AU - Kino, K.
AU - Irie, H.
AU - Kioka, Y.
AU - Indo, S.
AU - Kawakami, S.
AU - Yamada, M.
AU - Shimizu, N.
DA - Sep
DO - 10.1111/j.1525-1594.1994.tb03401.x
DP - NLM
ET - 1994/09/01
IS - 9
J2 - Artificial organs
KW - Adult
Aged
Assisted Circulation
Cardiac Surgical Procedures/adverse effects
Female
Humans
Male
Middle Aged
Postoperative Complications/*therapy
Shock, Cardiogenic/etiology/mortality/*therapy
LA - eng
N1 - Murakami, T
Kino, K
Irie, H
Kioka, Y
Indo, S
Kawakami, S
Yamada, M
Shimizu, N
Journal Article
United States
Artif Organs. 1994 Sep;18(9):691-7. doi: 10.1111/j.1525-1594.1994.tb03401.x.
PY - 1994
SN - 0160-564X (Print)
0160-564x
SP - 691-7
ST - Results of circulatory support for postoperative cardiogenic shock
T2 - Artif Organs
TI - Results of circulatory support for postoperative cardiogenic shock
VL - 18
ID - 3100
ER -
TY - JOUR
AB - BACKGROUND: Atrial fibrillation (AF) adversely affects surgical outcomes of
mitral valve surgery. However, the long-term impact of Maze procedure has not been
clear yet. PATIENTS AND METHODS: We retrospectively investigated 159 patients who
underwent mitral valve repair for degenerative mitral regurgitation with persistent
AF between 1991 and 2010. The mean age of patients was 63.1 ± 10.5 years. After we
started performing Maze procedure in 2002, 65 patients underwent concomitant Maze
procedure. The median follow-up time was 7.5 years. RESULTS: There was one
operative death (0.63%). The overall survival rate was 91.0 ± 2.6% at 5 years and
79.1 ± 4.7% at 10 years. Survival was significantly better in patients who
underwent Maze procedure than those who did not. The rate of freedom from AF in
patients who underwent Maze procedure was 86.4 ± 4.5% at 1 year and 81.1 ± 5.6% at
5 years. The freedom rate from stroke was higher in patients who underwent Maze
procedure than those who did not. Patients with postoperative AF had larger left
ventricular systolic and diastolic diameters at follow-up and higher New York Heart
Association functional class than patients without postoperative AF (1.4 ± 0.5 vs.
1.1 ± 0.3, p < 0.001). CONCLUSION: Maze procedure can have a positive effect on
long-term survival, freedom from stroke, and cardiac function.
AD - Department of Cardiovascular Surgery, Kobe City Medical Center General
Hospital, Kobe, Hyogo, Japan.
AN - 25025890
AU - Murashita, T.
AU - Okada, Y.
AU - Kanemitsu, H.
AU - Fukunaga, N.
AU - Konishi, Y.
AU - Nakamura, K.
AU - Koyama, T.
DA - Apr
DO - 10.1055/s-0034-1383719
DP - NLM
ET - 2014/07/16
IS - 3
J2 - The Thoracic and cardiovascular surgeon
KW - Aged
Comorbidity
Female
*Heart Valve Prosthesis Implantation
Humans
Male
Middle Aged
*Mitral Valve Annuloplasty
Mitral Valve Insufficiency/*epidemiology/*surgery
Postoperative Complications/epidemiology
Stroke/epidemiology
Treatment Outcome
LA - eng
N1 - 1439-1902
Murashita, Takashi
Okada, Yukikatsu
Kanemitsu, Hideo
Fukunaga, Naoto
Konishi, Yasunobu
Nakamura, Ken
Koyama, Tadaaki
Journal Article
Germany
Thorac Cardiovasc Surg. 2015 Apr;63(3):243-9. doi: 10.1055/s-0034-1383719. Epub
2014 Jul 15.
PY - 2015
SN - 0171-6425
SP - 243-9
ST - Long-term outcomes after mitral valve repair for degenerative mitral
regurgitation with persistent atrial fibrillation
T2 - Thorac Cardiovasc Surg
TI - Long-term outcomes after mitral valve repair for degenerative mitral
regurgitation with persistent atrial fibrillation
VL - 63
ID - 2599
ER -
TY - JOUR
AB - The insertion of implantable cardioverter/defibrillators (ICD) requires
induction of repeated episodes of ventricular fibrillation (VF). The
neuropsychological repercussions associated with repeated inducement of hypotension
and cerebral ischemia are unknown. In this prospective clinical trial, 1 day prior
to ICD assessment/implantation and 5 days postprocedure, 14 patients underwent
neurological and cognitive screening. Cognitive dysfunction was defined as impaired
performance in one of four cognitive domains. Neurological impairment was defined
as a decrement of 2 or more points from baseline of a total possible score of 45
points. Intraoperative hemodynamics, including the reperfusion interval (RI; end of
preceding fibrillation to beginning of the next), were recorded. Patients underwent
an average of 12 +/- 6 episodes of VF with average duration of mean arterial
pressure (MAP) <50 mm Hg for 17 +/- 9 s (range 6-39 s) and of MAP <30 mm Hg for 11
+/- 5 s (range 2-22 s). Nine patients, in none of whom the predetermined criteria
for neurologic impairment was met, demonstrated a new subtle neurologic finding
postoperatively. Ten of 14 patients met the criterion for cognitive dysfunction 5
days postoperatively. The mean RI between episodes of VF was significantly
different between those patients demonstrating cognitive dysfunction and the
unimpaired patients (3.1 +/- 0.5 min in the group with cognitive dysfunction vs 3.9
+/- 0.8 min in the unimpaired group, P = 0.027). Five patients without cognitive
impairment had longer RI between episodes of circulatory arrest than those showing
impaired cognition. We conclude that cognitive dysfunction can occur after
insertion of ICD and is related to the duration of RI.
AD - Department of Anaesthesia, London Health Sciences Centre, University of
Western Ontario, Canada. jmurkin@julian.uwo.ca
AN - 9174290
AU - Murkin, J. M.
AU - Baird, D. L.
AU - Martzke, J. S.
AU - Yee, R.
DA - Jun
DO - 10.1097/00000539-199706000-00003
DP - NLM
ET - 1997/06/01
IS - 6
J2 - Anesthesia and analgesia
KW - Adult
Aged
Central Nervous System/physiology
Cognition Disorders/*etiology
Female
Humans
Intraoperative Care
Male
Middle Aged
Myocardial Reperfusion/*methods
Myocardial Reperfusion Injury/*etiology
Prospective Studies
Time Factors
Ventricular Fibrillation/*complications/*therapy
LA - eng
N1 - Murkin, J M
Baird, D L
Martzke, J S
Yee, R
Clinical Trial
Journal Article
United States
Anesth Analg. 1997 Jun;84(6):1186-92. doi: 10.1097/00000539-199706000-00003.
PY - 1997
SN - 0003-2999 (Print)
0003-2999
SP - 1186-92
ST - Cognitive dysfunction after ventricular fibrillation during implantable
cardiovertor/defibrillator procedures is related to duration of the reperfusion
interval
T2 - Anesth Analg
TI - Cognitive dysfunction after ventricular fibrillation during implantable
cardiovertor/defibrillator procedures is related to duration of the reperfusion
interval
VL - 84
ID - 2937
ER -
TY - JOUR
AB - Some cryptogenic strokes are caused by undetected paroxysmal atrial
fibrillation (AF) and could benefit from oral anticoagulation. In this study, we
searched for echocardiographic parameters associated with first diagnosed AF, to
form a scoring system for the identification of patients with AF. We examined 571
patients with ischemic stroke (72.7 ± 13.5 years, 50.6% women), subdivided into 4
groups: documented cause without AF, first diagnosed AF, known paroxysmal AF, and
permanent AF. All patients underwent transthoracic echocardiography, brain computed
tomography scan, carotid/vertebral ultrasound, and continuous electrocardiographic
monitoring. Eight factors independently characterized first diagnosed AF and formed
the "MrWALLETS" score: mitral regurgitation, mild-to-moderate (+1), white matter
lesions (-1), age ≥75 years (+1), left atrium ≥4 cm (+1), cerebral lesion diameter
≥4 cm (+1), left ventricular end-diastolic volume <65 ml (+1), tricuspid
regurgitation ≥moderate (+1), carotid stenosis ≥50% (-1). In the patients with ≥3
points, positive predictive value was 80%, specificity 97.5%, and sensitivity
57.1%. In the patients with ≥2 points sensitivity rose to 85.7%, but positive
predictive value was 47.1%. The area under the receiver-operating characteristic
curve was 0.89 (95% CI 0.83 to 0.95). There were important differences among AF
groups, which therefore could not be merged. In conclusion, 4 echocardiographic
parameters, 3 additional instrumental parameters, and age allow the identification
of stroke patients with first diagnosed AF with high positive predictive value.
AD - Stroke Unit, Medical Department of Continuity of Care and Disability,
S.Orsola-Malpighi Hospital, Bologna, Italy; Department of Medical and Surgical
Sciences, University of Bologna, Bologna, Italy. Electronic address:
antonio.muscari@unibo.it.
Stroke Unit, Medical Department of Continuity of Care and Disability, S.Orsola-
Malpighi Hospital, Bologna, Italy.
Diagnostic and Interventional Neuroradiology Unit, Department of Head, Neck and
Sensory Organs, S.Orsola-Malpighi Hospital, Bologna, Italy.
Department of Cardiothoracic and Vascular Medicine, S.Orsola-Malpighi Hospital,
Bologna, Italy.
Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Malpighi Hospital, Bologna, Italy; Department of Medical and Surgical Sciences,
University of Bologna, Bologna, Italy.
AN - 28153345
AU - Muscari, A.
AU - Bonfiglioli, A.
AU - Faccioli, L.
AU - Ghinelli, M.
AU - Magalotti, D.
AU - Manzetto, F.
AU - Pontarin, A.
AU - Puddu, G. M.
AU - Spinardi, L.
AU - Tubertini, E.
AU - Zoli, M.
DA - Apr 1
DO - 10.1016/j.amjcard.2016.12.009
DP - NLM
ET - 2017/02/06
IS - 7
KW - Aged
Aged, 80 and over
Atrial Fibrillation/*complications/*diagnostic imaging
Electrocardiography
Female
Humans
Male
Stroke/*etiology
LA - eng
N1 - 1879-1913
Muscari, Antonio
Bonfiglioli, Andrea
Faccioli, Luca
Ghinelli, Marco
Magalotti, Donatella
Manzetto, Francesco
Pontarin, Anna
Puddu, Giovanni M
Spinardi, Luca
Tubertini, Eleonora
Zoli, Marco
Journal Article
United States
2017 Jan 5.
PY - 2017
SN - 0002-9149
SP - 1023-1029
ST - Usefulness of the MrWALLETS Scoring System to Predict First Diagnosed Atrial
Fibrillation in Patients With Ischemic Stroke
T2 - Am J Cardiol
TI - Usefulness of the MrWALLETS Scoring System to Predict First Diagnosed Atrial
Fibrillation in Patients With Ischemic Stroke
VL - 119
ID - 2455
ER -
TY - JOUR
AB - BACKGROUND: The aim of this study was the detection of risk factors for
lacunar strokes with visible lesions on computed tomography (CT) scan, considering
in particular clinical characteristics, echocardiographic parameters, and carotid-
femoral pulse wave velocity (PWV, a marker of large-artery stiffness). Lacunar
strokes with very small or nonvisible lesions may have different risk factors.
METHODS: We examined 106 patients (mean age 66.9 ± 12.3 years, 60 men), including
55 patients with clinically lacunar stroke associated with deep ischemic lesions of
.3-1.5 cm on brain CT scan, and 51 control patients with cortical ischemic stroke,
with lesions of 2.5-10.0 cm. RESULTS: In multiple logistic regression, with respect
to cortical strokes, the following variables were independently associated with
lacunar strokes: tricuspid regurgitation velocity (inverse relationship, odds ratio
[OR] .13, 95% confidence interval [CI] .04-.43, P = .0007, cutoff at 228 cm/s),
mean systolic blood pressure (SBP) (OR 3.98, 95% CI 2.78-7.79, P = .008, cutoff at
145 mmHg), ever-smoker status (OR 2.68, 95% CI 1.06-6.80, P = .04), and atrial
fibrillation (inverse relationship, OR .11, 95% CI .01-1.00, P = .0496). In
univariate analysis, the patients with lacunar stroke also had a lower prevalence
of mitral regurgitation. There were no differences between the 2 groups in relation
to diabetes, cholesterol, left ventricular mass and dimensions, and PWV.
CONCLUSIONS: The patients with lacunar strokes with visible cerebral lesions on CT
scan, compared with the patients with cortical infarct, had a lower tricuspid
regurgitation velocity, a higher mean SBP, a greater prevalence of ever-smokers,
and a lower prevalence of atrial fibrillation.
AD - Stroke Unit, Medical Department of Continuity of Care and Disability,
S.Orsola-Malpighi Hospital, Bologna, Italy; Department of Medical and Surgical
Sciences, University of Bologna, Bologna, Italy. Electronic address:
antonio.muscari@unibo.it.
Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Malpighi Hospital, Bologna, Italy.
Diagnostic and Interventional Neuroradiology Unit, S.Orsola-Malpighi Hospital,
Bologna, Italy.
Malpighi Hospital, Bologna, Italy; Department of Medical and Surgical Sciences,
University of Bologna, Bologna, Italy.
AN - 27009611
AU - Muscari, A.
AU - Conte, C.
AU - Degli Esposti, D.
AU - Faccioli, L.
AU - Falcone, R.
AU - Kolce, B.
AU - Marabini, L.
AU - Puddu, G. M.
AU - Rosticci, M.
AU - Spinardi, L.
AU - Veronesi, M.
AU - Borghi, C.
AU - Zoli, M.
DA - Jun
DP - NLM
ET - 2016/03/25
IS - 6
KW - Aged
Atrial Fibrillation/diagnosis/epidemiology
Blood Pressure
Female
Humans
Hypertension/diagnosis/epidemiology/physiopathology
Italy/epidemiology
Logistic Models
Male
Middle Aged
*Multidetector Computed Tomography
Odds Ratio
Prevalence
Pulse Wave Analysis
Risk Factors
Smoking/adverse effects/epidemiology
Stroke, Lacunar/*diagnostic imaging/*epidemiology/physiopathology
Tricuspid Valve Insufficiency/diagnostic imaging/epidemiology/physiopathology
Vascular Stiffness
brain CT scan
echocardiogram
lacunar stroke
pulse wave velocity
tricuspid regurgitation
LA - eng
N1 - 1532-8511
Muscari, Antonio
Conte, Camilla
Degli Esposti, Daniela
Faccioli, Luca
Falcone, Roberta
Kolce, Besar
Marabini, Lisa
Puddu, Giovanni M
Rosticci, Martina
Spinardi, Luca
Veronesi, Maddalena
Borghi, Claudio
Zoli, Marco
Journal Article
United States
J Stroke Cerebrovasc Dis. 2016 Jun;25(6):1381-8. doi:
10.1016/j.jstrokecerebrovasdis.2016.01.050. Epub 2016 Apr 20.
PY - 2016
SN - 1052-3057
SP - 1381-8
ST - Risk Factors for Lacunar Strokes with Visible Cerebral Lesions on Computed
Tomography Scan
TI - Risk Factors for Lacunar Strokes with Visible Cerebral Lesions on Computed
Tomography Scan
VL - 25
ID - 2795
ER -
TY - JOUR
AB - The prognosis for patients with acute myocardial infarction has dramatically
improved within the last decades. Also the length of stay shortened substantially.
This review gives an ovreview about the current knowlegde of monitoring and length
of hospital stay after acute myocardial infarction. After uncomplicated STEMI
monitoring for 24 hours in the CCU without adverse event and discharge on the
morning of day 4 is feasible. After uncomplicated NSTEMI patients can be
transferred to a step down unit within 24 hours and discharged the day after or
after normalisation of the cardiac markers. In patients with complications such as
recurrent angina, congestive heart failure, complex ventricular arrhythmias longer
monitoring over 48-72 and hospital stays over 7-14 days seem necessary.
AD - Herzzentrum Ludwigshafen, Medizinische Klinik B, Ludwigshafen.
AN - 17882741
AU - Muth, K.
AU - Senges, J.
AU - Zeymer, U.
DA - Sep
DO - 10.1055/s-2007-985635
DP - NLM
ET - 2007/09/21
IS - 39
Humans
*Length of Stay
*Monitoring, Physiologic/standards/trends
Myocardial Infarction/*complications/*physiopathology
Prognosis
Recurrence
Risk Assessment
Shock, Cardiogenic/etiology
Stroke/etiology
Time Factors
LA - ger
N1 - 1439-4413
Muth, K
Senges, J
Zeymer, U
English Abstract
Journal Article
Review
Germany
Dtsch Med Wochenschr. 2007 Sep;132(39):2021-3. doi: 10.1055/s-2007-985635.
OP - Monitoring nach akutem Myokardinfarkt.
PY - 2007
SN - 0012-0472
SP - 2021-3
ST - [Monitoring after acute myocardial infarction]
TI - [Monitoring after acute myocardial infarction]
VL - 132
ID - 2628
ER -
TY - JOUR
AB - The activation of adrenergic and renin-angiotensin-aldosterone (RAA) systems
observed in patients with obstructive sleep apnoea syndrome (OSA) strongly affects
functional status of the cardiovascular system. In this paper we discuss the link
between obstructive sleep apnoea syndrome and common cardiovascular diseases such
as systemic and pulmonary hypertension, ischaemic heart disease, stroke, arrhythmia
and ventricular hypertrophy. We also present the importance of early pharmacologic
treatment in preventing cardiac hypertrophy and ventricular dysfunction in patients
with obstructive sleep apnoea syndrome.
AD - Katedry i Kliniki Chorób Wewnetrznych Akademii Medycznej w Lublinie.
misl@poczta.wprost.pl
AN - 15991558
AU - Myśliński, W.
AU - Dybała, A.
AU - Mosiewicz, J.
AU - Prystupa, A.
AU - Hanzlik, J.
DP - NLM
ET - 2005/07/05
IS - 1-2
J2 - Wiadomosci lekarskie (Warsaw, Poland : 1960)
KW - Arrhythmias, Cardiac/complications/drug therapy
Cardiovascular Diseases/complications/*drug therapy/etiology
Humans
Hypertension, Pulmonary/complications/drug therapy
Hypertrophy, Left Ventricular/complications/drug therapy
Myocardial Ischemia/complications/drug therapy
*Renin-Angiotensin System
Risk Factors
Sleep Apnea, Obstructive/*complications/*drug therapy
Stroke/complications/drug therapy
Treatment Outcome
LA - pol
N1 - Myśliński, Wojciech
Dybała, Andrzej
Mosiewicz, Jerzy
Prystupa, Andrzej
Hanzlik, Janusz
English Abstract
Journal Article
Review
Poland
Wiad Lek. 2005;58(1-2):78-83.
OP - Zaburzenia czynności układu sercowo-naczyniowego u chorych z zespołem
obturacyjnego bezdechu sennego.
PY - 2005
SN - 0043-5147 (Print)
0043-5147
SP - 78-83
ST - [Cardiovascular abnormalities in patients with obstructive sleep apnoea
syndrome]
T2 - Wiad Lek
TI - [Cardiovascular abnormalities in patients with obstructive sleep apnoea
syndrome]
VL - 58
ID - 2715
ER -
TY - JOUR
AB - Transcranial Doppler sonography has become a widely used method for detecting
cerebral circulating microemboli (ME) arising from the carotid arteries or the
heart. Yet, studies on subgroups of patients with distinct cardiac sources of
embolism are still limited. The same holds true for investigation on the
relationship between microembolization and hemorheological parameters. A total of
142 patients suffering from left ventricular aneurysm (LVA, n = 52), severe left
ventricular dysfunction (LVD, n = 43), or chronic atrial fibrillation (AF, n = 47)
were enrolled in this study. All patients had been neurologically asymptomatic for
at least 1 month. Further relevant embolic disorders of the carotid arteries and
the heart had been excluded. Unilateral monitoring for ME over the middle cerebral
artery was performed for 30 min. Blood was drawn after each monitoring for
determination of plasmatic coagulation parameters, as well as plasma viscosity, and
platelet reactivity. The overall prevalence of ME was 31%, with a slightly higher
prevalence in patients with LVA (37%) compared to patients suffering from AF (30%)
or LVD (26%). With single-factor analysis, a trend towards higher ME prevalences
was found with (a) a history of remote embolic events, (b) ineffective
anticoagulation, (c) increased platelet aggregation, or (d) increased plasma
viscosity (all p > 0.1). The combination of ineffective anticoagulation in
conjunction with increased platelet aggregation, however, was significantly
associated with higher ME rates even after adjustment for other factors by logistic
regression analysis. Our results demonstrate a low ongoing microembolic activity in
asymptomatic patients suffering from LVA, LVD and AF. An activated plasmatic
coagulation system together with increased platelet aggregation contributes to ME
generation.
AD - Department of Neurology, Westfälische Wilhelms-Universität, Münster, Germany.
Nabavi@uni-muenster.de
AN - 9684061
AU - Nabavi, D. G.
AU - Arato, S.
AU - Droste, D. W.
AU - Schulte-Altedorneburg, G.
AU - Kemény, V.
AU - Reinecke, H.
AU - Borggrefe, M.
AU - Breithardt, G.
AU - Ringelstein, E. B.
DA - Jul-Aug
DO - 10.1159/000015854
DP - NLM
ET - 1998/07/31
IS - 4
KW - Adult
Coronary Aneurysm/*complications
Female
*Hemorheology
Humans
Intracranial Embolism and Thrombosis/epidemiology/*etiology
Logistic Models
Male
Middle Aged
Prevalence
Regression Analysis
LA - eng
N1 - Nabavi, D G
Arato, S
Droste, D W
Schulte-Altedorneburg, G
Kemény, V
Reinecke, H
Borggrefe, M
Breithardt, G
Ringelstein, E B
Comparative Study
Journal Article
Switzerland
Cerebrovasc Dis. 1998 Jul-Aug;8(4):214-21. doi: 10.1159/000015854.
PY - 1998
SN - 1015-9770 (Print)
1015-9770
SP - 214-21
ST - Microembolic load in asymptomatic patients with cardiac aneurysm, severe
ventricular dysfunction, and atrial fibrillation. Clinical and hemorheological
correlates
TI - Microembolic load in asymptomatic patients with cardiac aneurysm, severe
ventricular dysfunction, and atrial fibrillation. Clinical and hemorheological
correlates
VL - 8
ID - 3001
ER -
TY - JOUR
AB - BACKGROUND: Cardiac troponin I (cTI) release occurs frequently after
subarachnoid hemorrhage (SAH) and has been associated with a neurogenic form of
myocardial injury. The prognostic significance and clinical impact of these
elevations remain poorly defined. METHODS AND RESULTS: We studied 253 SAH patients
who underwent serial cTI measurements for clinical or ECG signs of potential
cardiac injury. These patients were drawn from an inception cohort of 441 subjects
enrolled in the Columbia University SAH Outcomes Project between November 1998 and
August 2002. Peak cTI levels were divided into quartiles or classified as
undetectable. Adverse in-hospital events were prospectively recorded, and outcome
at 3 months was assessed with the modified Rankin Scale. Admission predictors of
cTI elevation included poor clinical grade, intraventricular hemorrhage, loss of
consciousness at ictus, global cerebral edema, and a composite score of
physiological derangement (all P< or =0.01). Peak cTI level was associated with an
increased risk of echocardiographic left ventricular dysfunction (odds ratio [OR],
1.3 per quintile; 95% CI, 1.0 to 1.7; P=0.03), pulmonary edema (OR, 2.1 per
quintile; 95% CI, 1.6 to 2.7; P<0.001), hypotension requiring pressors (OR, 1.9 per
quintile; 95% CI, 1.5 to 2.3; P<0.001), and delayed cerebral ischemia from
vasospasm (OR, 1.3 per quintile; 95% CI, 1.07 to 1.7; P=0.01). Peak cTI levels were
predictive of death or severe disability at discharge after controlling for age,
clinical grade, and aneurysm size (adjusted OR, 1.4 per quintile; 95% CI, 1.1 to
1.9; P=0.02), but this association was no longer significant at 3 months.
CONCLUSIONS: cTI elevation after SAH is associated with an increased risk of
cardiopulmonary complications, delayed cerebral ischemia, and death or poor
functional outcome at discharge.
AD - Department of Neurology, Columbia University College of Physicians and
Surgeons, New York, NY, USA.
AN - 16267258
AU - Naidech, A. M.
AU - Kreiter, K. T.
AU - Janjua, N.
AU - Ostapkovich, N. D.
AU - Parra, A.
AU - Commichau, C.
AU - Fitzsimmons, B. F.
AU - Connolly, E. S.
AU - Mayer, S. A.
DA - Nov 1
DP - NLM
ET - 2005/11/04
IS - 18
J2 - Circulation
KW - Adult
Aged
Cohort Studies
Electrocardiography
Female
Heart Function Tests
Humans
Long QT Syndrome/epidemiology
Male
Middle Aged
Risk Factors
Subarachnoid Hemorrhage/metabolism/mortality/*physiopathology
Survival Analysis
Treatment Outcome
Troponin I/*metabolism
LA - eng
N1 - 1524-4539
Naidech, Andrew M
Kreiter, Kurt T
Janjua, Nazli
Ostapkovich, Noeleen D
Parra, Augusto
Commichau, Christopher
Fitzsimmons, Brian-Fred M
Connolly, E Sander
Mayer, Stephan A
Journal Article
United States
PY - 2005
SN - 0009-7322
SP - 2851-6
ST - Cardiac troponin elevation, cardiovascular morbidity, and outcome after
T2 - Circulation
TI - Cardiac troponin elevation, cardiovascular morbidity, and outcome after
VL - 112
ID - 3049
ER -
TY - JOUR
AB - BACKGROUND: The effect of mitral regurgitation (MR) on the incidence of new
cerebrovascular accidents (CVA) and mortality in patients with atrial fibrillation
(AF) and left atrial thrombus (LAT) is unknown. OBJECTIVE: To investigate the
effect of MR in patients with AF and LAT on new CVA and mortality. METHODS: Eighty
nine consecutive patients, mean age 71 years, with AF and LAT documented by
transesophageal echocardiography were investigated to determine the prevalence and
severity of MR and the association of the severity of MR with new cerebrovascular
accidents (CVA) and mortality at 34-mo follow-up. RESULTS: Of 89 patients, 1 + MR
was present in 23 patients (26%), 2 + MR in 44 patients (50%), 3 + MR in 17
patients (19%), and 4 + MR in 3 patients (4%). Mean follow-up was 34 +/- 28 mo. The
Cox proportional hazards model showed that the severity of increased MR did not
significantly increase new CVA or mortality at 34-mo follow-up. The only variable
predictive of mortality was left ventricular ejection fraction (LVEF), and with
every unit increase in LVEF, the risk decreased by 3%. CONCLUSION: MR occurred in
87 of 89 patients (98%) with AF and LAT. There was no association between the
severity of MR and the incidence of CVA or mortality.
AD - Cardiac Center of Creighton University, Omaha, Nebraska, USA.
AN - 19813267
AU - Nair, C. K.
AU - Aronow, W. S.
AU - Shen, X.
AU - Anand, K.
AU - Holmberg, M. J.
AU - Esterbrooks, D. J.
C2 - PMC6652993
DA - Nov
DO - 10.1002/clc.20433
DP - NLM
ET - 2009/10/09
IS - 11
KW - Adult
Aged
Aged, 80 and over
Atrial Fibrillation/*complications/diagnostic imaging/mortality/physiopathology
Echocardiography, Doppler, Color
Female
Humans
Incidence
Male
Middle Aged
Mitral Valve Insufficiency/*complications/diagnostic
Prevalence
Risk Assessment
Risk Factors
Stroke/*etiology/mortality/physiopathology
Stroke Volume
Thrombosis/diagnostic imaging/*etiology/mortality/physiopathology
Time Factors
LA - eng
N1 - 1932-8737
Nair, Chandra K
Aronow, Wilbert S
Shen, Xuedong
Anand, Kishlay
Holmberg, Mark J
Esterbrooks, Dennis J
Journal Article
Clin Cardiol. 2009 Nov;32(11):E7-E10. doi: 10.1002/clc.20433.
PY - 2009
SN - 0160-9289 (Print)
0160-9289
SP - E7-e10
ST - Effect of mitral regurgitation on cerebrovascular accidents in patients with
atrial fibrillation and left atrial thrombus
T2 - Clin Cardiol
TI - Effect of mitral regurgitation on cerebrovascular accidents in patients with
atrial fibrillation and left atrial thrombus
VL - 32
ID - 2525
ER -
TY - JOUR
AB - To investigate possible factors predicting cerebral infarction (CI) in
patients with non-rheumatic atrial fibrillation, we reviewed the clinical records
of 79 patients in whom conversion from sinus rhythm to persistent atrial
fibrillation was confirmed by serial electrocardiographic tracings. The patients
averaged 68.4 years in age and their average observation period after transition to
persistent atrial fibrillation was 4.1 years. During the observation period, 20
patients developed CI. CI occurred in 10 of 22 patients with hypertensive heart
disease, but in only three of 30 patients with lone atrial fibrillation and the
difference was statistically significant (p less than 0.01). We compared
demographic and pathophysiologic factors recorded at the onset of fixed atrial
fibrillation between groups with and without CI. There were no significant
differences in age, sex, smoking habits, diabetic complications and serum
cholesterol level, but hematocrit level was significantly higher in patients with
CI than in those without CI (45.3 +/- 3.2% vs 42.3 +/- 4.4%, p less than 0.01). The
cardiothoracic ratio was not significantly different, but echocardiographic left
atrial dimension was significantly greater in patients with CI than in those
without CI (43.7 +/- 3.3 mm vs 38.6 +/- 5.8 mm, p less than 0.01). The left
ventricular ejection fraction was significantly lower in patients with CI than in
those without CI (62.2 +/- 16.6% vs 72.9 +/- 8.2%, p less than 0.05) and congestive
heart failure was significantly more frequent in patients with CI than in those
without CI (40.0% vs 13.6%, p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
AD - Institute for Adult Diseases, Asahi Life Foundation, Tokyo.
AN - 2151777
AU - Naito, S.
AU - Imataka, K.
AU - Seko, Y.
AU - Fujii, J.
DP - NLM
ET - 1990/01/01
IS - 2
KW - Aged
Cerebral Infarction/*etiology
Echocardiography
Electrocardiography
Female
Hematocrit
Humans
Male
Middle Aged
Prognosis
LA - jpn
N1 - Naito, S
Imataka, K
Seko, Y
Fujii, J
English Abstract
Journal Article
Netherlands
J Cardiol. 1990;20(2):385-91.
PY - 1990
SN - 0914-5087 (Print)
0914-5087
SP - 385-91
ST - [The predictive factors for cerebral infarction in patients with non-
rheumatic atrial fibrillation]
T2 - J Cardiol
TI - [The predictive factors for cerebral infarction in patients with non-
rheumatic atrial fibrillation]
VL - 20
ID - 2739
ER -
TY - JOUR
AB - Three cases of isolated right ventricular infarction resulting from
thrombotic occlusion of a hypoplastic right coronary artery were found in 4,000
consecutive autopsies performed at Tokyo Metropolitan Geriatric Hospital. The
incidence of isolated right ventricular infarction was 0.08%. The clinical profile
of the first case was characterized by shock, pulmonary congestion, pleural
effusion, decreased V1R and V2R on ECG, a small elevation of CPK and transaminase,
elevation of fibrin degenerative products and decreased platelet count. The patient
responded to volume expansion, heparin and catecholamines. One year later she died
from cerebral bleeding. In the second case, mild aortic regurgitation and atrial
fibrillation were present. He died suddenly during an episode of pneumonia. In the
third case, there was chronic obstructive lung disease, atrial fibrillation and
lung cancer. He died of respiratory failure. On autopsy, the coronary arteries
revealed a marked left dominant and right hypoplastic pattern in all cases. The
right coronary artery perfused only the free wall of the right ventricle. Complete
occlusion of the hypoplastic right coronary artery resulted in isolated right
ventricular infarction. In addition, chronic pulmonary disease and arrhythmia may
be contributory.
AD - Department of Cardiology, Tokyo Metropolitan Geriatric Hospital, Japan.
AN - 2724533
AU - Nakahara, K.
AU - Matsushita, S.
AU - Ohkawa, S.
AU - Kuramoto, K.
DA - Jan
DO - 10.1536/ihj.30.95
DP - NLM
ET - 1989/01/01
IS - 1
J2 - Japanese heart journal
KW - Aged
Aged, 80 and over
Coronary Thrombosis/*complications
Coronary Vessel Anomalies/*complications
Electrocardiography
Female
Heart Ventricles
Humans
Male
Myocardial Infarction/*etiology/pathology/physiopathology
LA - eng
N1 - Nakahara, K
Matsushita, S
Ohkawa, S
Kuramoto, K
Case Reports
Journal Article
Japan
Jpn Heart J. 1989 Jan;30(1):95-101. doi: 10.1536/ihj.30.95.
PY - 1989
SN - 0021-4868 (Print)
0021-4868
SP - 95-101
ST - Isolated right ventricular infarction resulting from thrombotic occlusion of
a hypoplastic right coronary artery
T2 - Jpn Heart J
TI - Isolated right ventricular infarction resulting from thrombotic occlusion of
a hypoplastic right coronary artery
VL - 30
ID - 3074
ER -
TY - JOUR
AB - Syncope, a common symptom of cerebral ischemia often shows a multifactorial
etiopathogenesis. Although inherited arrhythmias causing syncope is uncommon, such
an occurrence could be a warning sign preceding cardiac arrest. Long QT syndrome
(LQTS) is a typical inherited arrhythmia causing syncope in children. Early
diagnosis and treatment of LQTS using beta-blockers prevents recurrent syncope in
LQTS. Brugada syndrome, another typical inherited arrhythmia causes syncope or
sudden cardiac arrest in young individuals. Syncope as a symptom is useful for risk
stratification of fatal arrhythmias and in selection of appropriate therapy.
Catecholaminergic polymorphic ventricular tachycardia, another rare inherited
arrhythmia causing recurrent syncope is associated with poor outcomes without
medication. Early detection and therapeutic intervention improve prognosis; thus,
correct diagnosis of syncope is imperative in cases of these inherited arrhythmias.
We describe syncope associated with three typical inherited arrhythmias and discuss
various diagnostic modalities.
AD - Department of Cardiovascular Medicine, Division of Frontier Medical Science,
Programs for Biomedical Research, Graduate School of Biomedical Science, Hiroshima
University, 1-2-3 Kasumi, Minami-ku, Hiroshima734-8551, Japan.
Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan.
AN - 29255503
AU - Nakano, Y.
AU - Wataru, S.
C2 - PMC5728986
DA - Dec
DO - 10.1016/j.joa.2017.07.007
DP - NLM
ET - 2017/12/20
IS - 6
J2 - Journal of arrhythmia
KW - Brugada syndrome
Catecholaminergic polymorphic ventricular tachycardia
Inherited arrhythmia
Long QT syndrome
Syncope
LA - eng
N1 - 1883-2148
Nakano, Yukiko
Wataru, Shimizu
Journal Article
Review
J Arrhythm. 2017 Dec;33(6):572-578. doi: 10.1016/j.joa.2017.07.007. Epub 2017 Oct
6.
PY - 2017
SN - 1880-4276 (Print)
1880-4276
SP - 572-578
ST - Syncope in patients with inherited arrhythmias
T2 - J Arrhythm
TI - Syncope in patients with inherited arrhythmias
VL - 33
ID - 3058
ER -
TY - JOUR
AB - From July 1988 through August 1996, 54 patients with chronic renal failure
(CRF) on maintenance dialysis (50 hemodialysis = HD, and 4 continuous ambulatory
peritoneal dialysis) have undergone some sort of surgical procedure requiring the
use of extra corporeal circulation (ECC); 42 patients underwent isolated coronary
artery bypass grafting (CABG), 8 valve replacement, 3 combined procedures and 1
correction of a congenital heart defect. The protocol called for maintenance
dialysis on the day before surgery, large volume hemofiltration (HF) during the ECC
period, postoperative K+ management with dextrose-insulin if required, and
resumption of whatever preoperative maintenance dialysis 24 hours after the
operative procedure. The mean diafiltrate volume of HF was 7963 +/- 2688 ml which
was replaced with 6342 +/- 2748 ml. No patient required emergency HD before the
resumption of the maintenance dialysis, although in 40% of the early patients HD
was added on the second postoperative day. However as experience was gained, in the
latter 60% of patients resumption of maintenance dialysis (HD 3 times a week) was
thought to be sufficient. The incidence of calcification in patients with CRF is
higher not only of involved coronary artery segments (4.5 +/- 2.3 segments; AHA
coronary classification) than its counterpart without CRF, but also of the
ascending aorta which mandated modifications of the technique in 6 patients
(operation under ventricular fibrillation, cannulation access other than ascending
aorta). The use of arterial in situ conduits for CABG was also thought to be
advantageous, and the left internal thoracic artery combined to the gastro-epiploic
artery was used in 11 patients (26.2%). Four patients died) (7.4%): 2 from
arrhythmia, one from intestinal necrosis and one from multiple cerebral infarction.
Thus we conclude that the outlined protocol is quite effective in controlling fluid
and electrolyte balance in patients on maintenance dialysis allowing to undertake
surgical procedures requiring the use of extra corporeal circulation relatively
safely.
AD - Department of Cardiovascular Surgery, Kumamoto Chu-oh Hospital, Japan.
AN - 9394573
AU - Nakayama, Y.
AU - Sakata, R.
AU - Ueyama, K.
AU - Ura, M.
AU - Kamohara, K.
AU - Mabuni, K.
AU - Arai, Y.
DA - Oct
DP - NLM
ET - 1997/12/12
IS - 10
J2 - [Zasshi] [Journal]. Nihon Kyobu Geka Gakkai
KW - Adult
Aged
Aged, 80 and over
Coronary Disease/surgery
Female
Heart Valve Diseases/surgery
Humans
Kidney Failure, Chronic/*complications/therapy
Male
Middle Aged
Peritoneal Dialysis, Continuous Ambulatory
*Renal Dialysis
LA - jpn
N1 - Nakayama, Y
Sakata, R
Ueyama, K
Ura, M
Kamohara, K
Mabuni, K
Arai, Y
English Abstract
Journal Article
Japan
Nihon Kyobu Geka Gakkai Zasshi. 1997 Oct;45(10):1661-6.
PY - 1997
SN - 0369-4739 (Print)
0369-4739
SP - 1661-6
ST - [Cardiac surgery in patients with chronic renal failure on maintenance
dialysis]
T2 - Nihon Kyobu Geka Gakkai Zasshi
TI - [Cardiac surgery in patients with chronic renal failure on maintenance
dialysis]
VL - 45
ID - 3119
ER -
TY - JOUR
AB - Patients with cerebral stroke develop electrocardiographic changes concerning
the period of ventricular muscle repolarization and cardiac arrhythmias, which may
results in the possibility of acute circulatory arrest. ECG monitoring by means of
Holter method provides not only information concerning arrhythmias, episodes of
ischaemia of the cardiac muscle, but it is also a recognised and generally accepted
method of investigation of the autonomic system. The aim of the study was to assess
the incidence of arrhythmias and heart rate variability in patients suffering from
recent cerebral stroke. The studies involved 36 patients, in that 22 women (mean
age 67.7 +/- 7.2 years) and 14 men (mean age 66.5 +/- 11.3 years) within first 24
hours after cerebral stroke confirmed by computerised tomography (CT). One the
basis of CT scan haemorrhagic stroke was diagnosed in 7 patients and ischaemic
stroke, after ruling out haemorrhagic stroke and neurological consultations, in 29
patients. Moreover, all patients revealed hypertension, 12 of them mild degree (1
degree), and 21 of moderate degree (2 degrees), and 3 of severe degree (3 degrees).
The control group comprised 65 patients suffering from primary hypertension without
concomitant cerebral stroke, matching the study group as to sex and age as well as
the degree of hypertension. All of them were submitted to 24-hour Holter monitoring
on tape by means of 3-channel registrator MR45, analysis of ECG tracings was
carried out according to Optima Jet system manufactured by Oxford. In order to
facilitate further analysis, the automatic recording was verified visually and next
heart rate variability (HRV) was estimated within 24 hours and separately for day
hours 6:00-22:00 and night hours 22:00-6:00. In comparison to patients with
hypertension, but without stroke, subjects with hypertension and accompanying
cerebral stroke more often reveal premature supraventricular beats, pairs of
ventricular beats as well as episodes of nonsustained ventricular tachycardia; they
also reveal lower 24-hours heart rate variability.
AD - Katedra i Klinika Kardiologii AM, Wrocławiu.
AN - 10405564
AU - Negrusz-Kawecka, M.
AU - Kobusiak-Prokopowicz, M.
DA - Dec
DP - NLM
ET - 1999/07/16
IS - 6
J2 - Polskie Archiwum Medycyny Wewnetrznej
KW - Aged
Arrhythmias, Cardiac/diagnosis/epidemiology/*etiology
Brain Ischemia/*complications/diagnostic imaging/epidemiology/physiopathology
Cerebral Hemorrhage/*complications/diagnostic imaging/epidemiology/physiopathology
Comorbidity
Female
Heart Rate
Humans
Hypertension/complications/epidemiology
Incidence
Male
Middle Aged
LA - pol
N1 - Negrusz-Kawecka, M
Kobusiak-Prokopowicz, M
Clinical Trial
Journal Article
Poland
Pol Arch Med Wewn. 1998 Dec;100(6):515-25.
OP - Badania nad czestościa wystepowania zaburzeń rytmu serca i zmiennościa rytmu
serca u chorych na udar mózgu.
PY - 1998
SP - 515-25
ST - [Studies of arrhythmia incidence and heart rate variability in patients
suffering from cerebral stroke]
T2 - Pol Arch Med Wewn
TI - [Studies of arrhythmia incidence and heart rate variability in patients
suffering from cerebral stroke]
VL - 100
ID - 2791
ER -
TY - JOUR
AB - AIMS: In patients with sick sinus syndrome, bradycardia can be treated with a
single-lead pacemaker or a dual-chamber pacemaker. Previous trials have revealed
that pacing modes preserving atrio-ventricular synchrony are superior to single-
lead ventricular pacing, but it remains unclear if there is any difference between
single-lead atrial pacing (AAIR) and dual-chamber pacing (DDDR). METHODS AND
RESULTS: We randomly assigned 1415 patients referred for first pacemaker
implantation to AAIR (n = 707) or DDDR (n = 708) pacing and followed them for a
mean of 5.4 ± 2.6 years. The primary outcome was death from any cause. Secondary
outcomes included paroxysmal and chronic atrial fibrillation, stroke, heart
failure, and need for pacemaker reoperation. In the AAIR group, 209 patients
(29.6%) died during follow-up vs. 193 patients (27.3%) in the DDDR group, hazard
ratio (HR) 1.06, 95% confidence interval (CI) 0.88-1.29, P = 0.53. Paroxysmal
atrial fibrillation was observed in 201 patients (28.4%) in the AAIR group vs. 163
patients (23.0%) in the DDDR group, HR 1.27, 95% CI 1.03-1.56, P = 0.024. A total
of 240 patients underwent one or more pacemaker reoperations during follow-up, 156
(22.1%) in the AAIR group vs. 84 (11.9%) in the DDDR group (HR 1.99, 95% CI 1.53-
2.59, P < 0.001). The incidence of chronic atrial fibrillation, stroke, and heart
failure did not differ between treatment groups. CONCLUSION: In patients with sick
sinus syndrome, there is no statistically significant difference in death from any
cause between AAIR pacing and DDDR pacing. AAIR pacing is associated with a higher
incidence of paroxysmal atrial fibrillation and a two-fold increased risk of
pacemaker reoperation. These findings support the routine use of DDDR pacing in
these patients. CLINICAL TRIAL REGISTRATION: URL http://www.clinicaltrials.gov.
Unique identifier: NCT00236158.
AD - Department of Cardiology B, Aarhus University Hospital, Skejby, Aarhus N,
Denmark. jenniels@rm.dk
AN - 21300730
AU - Nielsen, J. C.
AU - Thomsen, P. E.
AU - Højberg, S.
AU - Møller, M.
AU - Vesterlund, T.
AU - Dalsgaard, D.
AU - Mortensen, L. S.
AU - Nielsen, T.
AU - Asklund, M.
AU - Friis, E. V.
AU - Christensen, P. D.
AU - Simonsen, E. H.
AU - Eriksen, U. H.
AU - Jensen, G. V.
AU - Svendsen, J. H.
AU - Toff, W. D.
AU - Healey, J. S.
AU - Andersen, H. R.
DA - Mar
DO - 10.1093/eurheartj/ehr022
DP - NLM
ET - 2011/02/09
IS - 6
KW - Adolescent
Adult
Aged
Atrial Fibrillation/etiology/mortality
Cause of Death
Female
Follow-Up Studies
Humans
Male
Middle Aged
Reoperation/statistics & numerical data
Sick Sinus Syndrome/mortality/*therapy
Treatment Outcome
Young Adult
LA - eng
N1 - 1522-9645
Nielsen, Jens Cosedis
Thomsen, Poul Erik B
Højberg, Søren
Møller, Mogens
Vesterlund, Thomas
Dalsgaard, Dorthe
Mortensen, Leif S
Nielsen, Tonny
Asklund, Mogens
Friis, Elsebeth V
Christensen, Per D
Simonsen, Erik H
Eriksen, Ulrik H
Jensen, Gunnar V H
Svendsen, Jesper H
Toff, William D
Healey, Jeffrey S
Andersen, Henning R
DANPACE Investigators
Comparative Study
Journal Article
Multicenter Study
England
Eur Heart J. 2011 Mar;32(6):686-96. doi: 10.1093/eurheartj/ehr022. Epub 2011 Feb 7.
PY - 2011
SN - 0195-668x
SP - 686-96
ST - A comparison of single-lead atrial pacing with dual-chamber pacing in sick
sinus syndrome
T2 - Eur Heart J
TI - A comparison of single-lead atrial pacing with dual-chamber pacing in sick
sinus syndrome
VL - 32
ID - 2612
ER -
TY - JOUR
AB - BACKGROUND: We investigated the prevalence of ventricular
tachycardia/ventricular fibrillation (VT/VF) in Post-infarction left ventricular
aneurysm (PI-LVA) patients and analyze clinical outcomes in patients presenting
with VT/VF. METHODS: 575 PI-LVA patients were enrolled and investigated by logistic
regression analysis. Patients with VT/VF were followed up, the composite primary
endpoint was cardiac death and appropriate ICD/external shocks. RESULTS: The
incidence of sustained VT/VF was 11%. Logistical regression analysis showed male
gender, enlarged LV end diastolic diameter (LVEDD) and higher NYHA class were
correlated with VT/VF development. During follow up of 46 ± 15 months, 19 out of
62(31%) patients reached study end point. Multivariate Cox regression analysis
revealed that enlarged LVEDD and moderate/severe mitral regurgitation (MR) were
independently predictive of clinical outcome. CONCLUSIONS: Male gender, enlarged
LVEDD and higher NYHA class associated with risk of sustained VT/VF in PI-LVA
patients. Among VT/VF positive patients, enlarged LVEDD and moderate/severe MR
independently predicted poor clinical prognosis.
AD - State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National
Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking
Union Medical College, China.
Department of Nuclear Medicine, Anzhen Hospital, China.
State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for
Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union
Medical College, China. Electronic address: zhangshufw@163.com.
AN - 29803411
AU - Ning, X.
AU - Ye, X.
AU - Si, Y.
AU - Yang, Z.
AU - Zhao, Y.
AU - Sun, Q.
AU - Chen, R.
AU - Tang, M.
AU - Chen, K.
AU - Zhang, X.
AU - Zhang, S.
DA - Jul-Aug
DO - 10.1016/j.jelectrocard.2018.03.010
DP - NLM
ET - 2018/05/29
IS - 4
J2 - Journal of electrocardiology
KW - Adult
Aged
Aged, 80 and over
Echocardiography
Female
Heart Aneurysm/*complications/diagnostic imaging/pathology
Heart Ventricles/diagnostic imaging/*pathology
Humans
Infarction, Middle Cerebral Artery/diagnostic imaging/etiology
Logistic Models
Male
Middle Aged
Mitral Valve Insufficiency/complications
Prevalence
Prognosis
Sex Factors
Stroke Volume
Tachycardia, Ventricular/epidemiology/*etiology
Ventricular Fibrillation/epidemiology/*etiology
*Left ventricular aneurysm
*Left ventricular end diastolic diameter
*Mitral regurgitation
*Ventricular tachycardia/ventricular fibrillation
LA - eng
N1 - 1532-8430
Ning, Xiaohui
Ye, Xuerui
Si, Yanhua
Yang, Zihe
Zhao, Yunzi
Sun, Qi
Chen, Ruohan
Tang, Min
Chen, Keping
Zhang, Xiaoli
Zhang, Shu
Journal Article
United States
J Electrocardiol. 2018 Jul-Aug;51(4):742-746. doi:
10.1016/j.jelectrocard.2018.03.010. Epub 2018 Mar 21.
PY - 2018
SN - 0022-0736
SP - 742-746
ST - Prevalence and prognosis of ventricular tachycardia/ventricular fibrillation
in patients with post-infarction left ventricular aneurysm: Analysis of 575 cases
T2 - J Electrocardiol
TI - Prevalence and prognosis of ventricular tachycardia/ventricular fibrillation
in patients with post-infarction left ventricular aneurysm: Analysis of 575 cases
VL - 51
ID - 2309
ER -
TY - JOUR
AB - A review is presented of 1094 selective coronary artery studies during a 3-
year period in which 7001 coronary artery injections were performed using the
percutaneous transfemoral artery approach as described by Judkins. A total of 24
serious complications occurred, including 11 ventricular fibrillations, 5 asystoles
or severe bradycardias, 3 acute myocardial infarctions and 5 cerebral vascular
accidents. There were 5 deaths, giving an overall mortality rate of 0.46%. Causes
of individual complications are analyzed. The incidence of serious cardiac
complications did not differ significantly from that reported in the literature
with the Sones technique. The Judkins technique is a simple and reliable method for
selective coronary arteriography. In our opinion, the incidence of complications
can be kept at an acceptably low level by meticulous examination techniques.
AN - 785955
AU - Nitter-Hauge, S.
AU - Enge, I.
DO - 10.1111/j.0954-6820.1976.tb08206.x
DP - NLM
ET - 1976/01/01
IS - 1-2
KW - Acute Disease
Angiography/*adverse effects
Bradycardia/etiology
Cerebrovascular Disorders/etiology
Femoral Artery
Humans
Injections, Intra-Arterial
Metrizoic Acid/adverse effects
Time Factors
LA - eng
N1 - Nitter-Hauge, S
Enge, I
Journal Article
Sweden
Acta Med Scand. 1976;200(1-2):123-126. doi: 10.1111/j.0954-6820.1976.tb08206.x.
PY - 1976
SN - 0001-6101 (Print)
0001-6101
SP - 123-126
ST - Complication rates of selective percutaneous transfemoral coronary
arteriography. A review of 1094 consecutive examinations
T2 - Acta Med Scand
TI - Complication rates of selective percutaneous transfemoral coronary
arteriography. A review of 1094 consecutive examinations
VL - 200
ID - 2957
ER -
TY - JOUR
AB - A 56-year-old man who complained of quadrantic hemianopsia was admitted to
determine its etiology. Cerebral angiography revealed no organic stenosis.
Echocardiography showed clear direct continuity between a hypertrophied
anterolateral papillary muscle and the anterior mitral leaflet, and the left
ventricular (LV) outflow tract (LVOT) was narrowed by the presence of an accessory
papillary muscle. The LVOT obstruction caused an intra-LV pressure overload that
resulted in LV concentric hypertrophy. Arrhythmia, such as paroxysmal atrial
fibrillation (PAF), was thought to have caused a cerebral embolism. Mitral valve
replacement (MVR), septal myectomy, and myectomy of the abnormal papillary muscle
were performed, and complete release of the LVOT obstruction was accomplished.
Anomalous insertion of papillary muscle is a rare cause of LVOT obstruction.
Echocardiography was useful in identifying the papillary muscle malformation, and
surgery was completely curative.
AD - Department of Cardiology, Maizuru Medical Center, Yukinaga, Maizuru, Japan.
prinom@eos.ocn.ne.jp
AN - 15564711
AU - Nomura, T.
AU - Harada, Y.
AU - Suzaki, Y.
AU - Hayashi, H.
AU - Tanaka, H.
AU - Shiraishi, J.
AU - Komatsu, S.
AU - Hosomi, Y.
AU - Hirano, S.
AU - Yaku, H.
AU - Kitamura, N.
DA - Dec
DO - 10.1253/circj.68.1219
DP - NLM
ET - 2004/11/27
IS - 12
KW - Cerebral Infarction/etiology
Echocardiography
Hemianopsia/etiology
Humans
Male
Middle Aged
Mitral Valve/surgery
Papillary Muscles/*abnormalities/*diagnostic imaging/pathology/surgery
Treatment Outcome
Ventricular Outflow Obstruction/*complications/*diagnostic
imaging/pathology/surgery
LA - eng
N1 - Nomura, Tetsuya
Harada, Yoshiaki
Suzaki, Yoko
Hayashi, Hironori
Tanaka, Hiroyuki
Shiraishi, Jun
Komatsu, Sumio
Hosomi, Yasuo
Hirano, Shinji
Yaku, Hitoshi
Kitamura, Nobuo
Case Reports
Journal Article
Japan
Circ J. 2004 Dec;68(12):1219-22. doi: 10.1253/circj.68.1219.
PY - 2004
SN - 1346-9843 (Print)
1346-9843
SP - 1219-22
ST - Left ventricular outflow tract obstruction due to anomalous insertion of
papillary muscle
T2 - Circ J
TI - Left ventricular outflow tract obstruction due to anomalous insertion of
papillary muscle
VL - 68
ID - 2958
ER -
TY - JOUR
AB - AIMS: In patients with atrial fibrillation (AF) and uncontrolled ventricular
rate, radiofrequency (RF) ablation of the atrioventricular (AV) node and pacemaker
(PM) implantation (ablate and pace) is a valid therapeutic approach, especially in
elderly patients. The aim of our study was to evaluate the PM dependence and the
incidence of correlated clinical phenomena in a patients population with AV block
induced by RF ablation of the AV junction. METHODS AND RESULTS: One-hundred and
sixty-three patients (71 men; mean age 71 +/- 8 years) who had undergone ablate and
pace therapy were evaluated. The patients underwent assessment of quality of life,
impairment of consciousness, stroke/transient ischaemic attack (TIA),
hospitalizations for heart failure, episodes of palpitations, and instrumental
evaluation of PM dependence during PM inhibition (absence of escape rhythm;
asystolic pause >5 s; escape rhythm <30 bpm after rhythm stabilization).
Correlation between instrumentally evaluated PM dependence and clinical history was
analysed. Hundred and thirty-two patients were evaluated after a mean follow-up
period of 36 months [31 subjects (19%) died before the evaluation]; 55 patients
(42%) were classified as PM-dependent: 38 (69%) complained of disturbances (19
dizziness, 15 pre-syncope, 4 syncope); 77 patients (58%) were considered non-PM-
dependent: symptoms (dizziness, flush) were reported by only 3 (4%). No significant
differences emerged between PM-dependent and non-PM-dependent patients with regard
to episodes of pre-syncope, syncope, stroke/TIA, hospitalizations for heart
failure, and quality of life. CONCLUSION: This study confirms that ablate and pace
is an effective and safe approach in subjects with chronic or recurrent AF and
uncontrolled ventricular rate.
AD - Cardiology Division, Azienda Ospedaliera Maggiore della Carità, Corso Mazzini
18, 28100 Novara, Italy. occhetta@r-j.it
AN - 17959682
AU - Occhetta, E.
AU - Bortnik, M.
AU - Dell'era, G.
AU - Zardo, F.
AU - Dametto, E.
AU - Sassone, B.
AU - Gabrieli, L.
AU - Marino, P.
DA - Dec
DP - NLM
ET - 2007/10/26
IS - 12
KW - Aged
Atrial Fibrillation/complications/physiopathology/*therapy
Atrioventricular Node/*surgery
*Cardiac Pacing, Artificial/adverse effects
*Catheter Ablation/adverse effects
Electrocardiography
Female
Follow-Up Studies
Humans
Ischemic Attack, Transient/etiology/prevention & control
Male
Middle Aged
Quality of Life
Syncope/etiology/prevention & control
Treatment Outcome
LA - eng
N1 - 1532-2092
Occhetta, Eraldo
Bortnik, Miriam
Dell'era, Gabriele
Zardo, Fabio
Dametto, Ermanno
Sassone, Biagio
Gabrieli, Luca
Marino, Paolo
Journal Article
Multicenter Study
England
Europace. 2007 Dec;9(12):1119-23. doi: 10.1093/europace/eum226. Epub 2007 Oct 24.
PY - 2007
SN - 1099-5129
SP - 1119-23
ST - Evaluation of pacemaker dependence in patients on ablate and pace therapy for
atrial fibrillation
T2 - Europace
TI - Evaluation of pacemaker dependence in patients on ablate and pace therapy for
atrial fibrillation
VL - 9
ID - 2573
ER -
TY - JOUR
AB - Atrial fibrillation (AF), the most common type of arrhythmia in adults, is a
major risk factor for stroke. The prevalence of AF increases with age, occurring in
1% of persons <60 years of age and in almost 10% of those >80 years of age. Recent
studies show that treatment strategies that combine control of ventricular rate
with antithrombotic therapy are as effective as strategies aimed at restoring sinus
rhythm. Current antithrombotic therapy regimens in patients with AF involve chronic
anticoagulation with dose-adjusted vitamin K antagonists unless patients have a
contraindication to these agents or are at low risk for stroke. Patients with AF at
low risk for stroke may benefit from aspirin. Although vitamin K antagonists are
effective, their use is problematic, highlighting the need for new antithrombotic
strategies. This article will (a) provide an overview of the clinical trials that
form the basis for current antithrombotic guidelines in patients with AF, (b)
highlight the limitations of current antithrombotic drugs used for stroke
prevention, (c) briefly review the pharmacology of new antithrombotic drugs under
evaluation in AF, (d) describe ongoing trials with new antiplatelet therapies and
idraparinux, and completed studies with ximelagatran in patients with AF, and (e)
provide clinical perspective into the potential role of new antithrombotic drugs in
AF.
AD - Henderson Research Centre, McMaster University, Hamilton, Ontario, Canada.
AN - 15152749
AU - O'Donnell, M.
AU - Weitz, J. I.
DA - Apr
DP - NLM
ET - 2004/05/22
IS - 3 Suppl
J2 - The American journal of managed care
KW - Adult
Aged
Aged, 80 and over
Female
Fibrinolytic Agents/administration & dosage/*therapeutic use
Humans
Male
Stroke/drug therapy/*prevention & control
LA - eng
N1 - O'Donnell, Martin
Weitz, Jeffrey I
Journal Article
Review
United States
Am J Manag Care. 2004 Apr;10(3 Suppl):S72-82.
PY - 2004
SN - 1088-0224 (Print)
1088-0224
SP - S72-82
ST - Novel antithrombotic therapies for the prevention of stroke in patients with
atrial fibrillation
T2 - Am J Manag Care
TI - Novel antithrombotic therapies for the prevention of stroke in patients with
atrial fibrillation
VL - 10
ID - 2691
ER -
TY - JOUR
AB - Statins, 3-hydroxy-methylglutaryl coenzyme A reductase inhibitors, have been
used for decades for the prevention of coronary artery disease and stroke. They act
primarily by lowering serum cholesterol through the inhibition of cholesterol
synthesis in the liver, which results in the upregulation of low-density
lipoprotein receptors in the liver. This results in the removal of low-density
lipoproteincholesterol. Studies have suggested that statins may demonstrate
additional effects that are independent of their effects on low-density
lipoprotein-cholesterol. These have been termed "pleiotropic" effects. Pleiotropic
effects may be due to the inhibition of isoprenoid intermediates by statins.
Isoprenoid inhibition has effects on the small guanosine triphosphate binding
proteins Rac and Rho which in turn effects nicotinamide adenine dinucleotide
phosphate oxidases. Therefore, there are changes in endothelial nitric oxide
synthase expression, atherosclerotic plaque stability, pro-inflammatory cytokines
and reactive oxygen species production, platelet reactivity, and cardiac fibrosis
and hypetrophy development. Recently, statins have been compared to the ezetimibe
and the recently published outcomes data on the proprotein convertase subtilisin
kexin type 9 inhibitors has allowed for a reexamination of statin pleiotropy. As a
result of these diverse effects, it has been suggested that statins also have anti-
arrhythmic effects. This review focuses on the mechanisms of statin pleiotropy and
discusses evidence from the statin clinical trials as well as examining the
possible anti-arrhythmic effects atrial fibrillation and ventricular
tachyarrhythmias.
AD - The Section of Cardiology, Department of Medicine, The University of Chicago,
Chicago, IL 60637, United States.
AN - 30124154
AU - Oesterle, A.
AU - Liao, J. K.
C2 - PMC6378117
C6 - NIHMS993094
DO - 10.2174/1570161116666180817155058
DP - NLM
ET - 2018/08/21
IS - 3
J2 - Current vascular pharmacology
KW - Animals
Atrial Fibrillation/diagnosis/mortality/*prevention & control
Coronary Artery Disease/diagnostic imaging/mortality/*prevention & control
Dyslipidemias/diagnosis/*drug therapy/mortality
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse
effects/pharmacokinetics/*therapeutic use
Risk Assessment
Risk Factors
Stroke/diagnosis/mortality/*prevention & control
Treatment Outcome
*Statins
*cholesterol
*coronary artery disease
*low density lipoprotein
*pleiotropy
*stroke.
otherwise.
LA - eng
N1 - 1875-6212
Oesterle, Adam
Liao, James K
Journal Article
Review
Curr Vasc Pharmacol. 2019;17(3):222-232. doi: 10.2174/1570161116666180817155058.
PY - 2019
SN - 1570-1611 (Print)
1570-1611
SP - 222-232
ST - The Pleiotropic Effects of Statins - From Coronary Artery Disease and Stroke
to Atrial Fibrillation and Ventricular Tachyarrhythmia
T2 - Curr Vasc Pharmacol
TI - The Pleiotropic Effects of Statins - From Coronary Artery Disease and Stroke
to Atrial Fibrillation and Ventricular Tachyarrhythmia
VL - 17
ID - 2298
ER -
TY - JOUR
AB - Atrial fibrillation (AF) may increase the risk of thromboembolic (TE)
complications in patients with left ventricular assist devices (LVADs). In a
single-center study, we investigated 205 patients with sinus rhythm (SR group) and
117 patients with AF (AF group). Our main read outs were 2 year overall survival
(primary end point), perioperative right heart failure (RHF), and 2 year freedom
from stroke, pump thrombosis, and gastrointestinal bleeding (secondary end points).
Oral anticoagulation was performed with phenprocoumon (international normalized
ratio target range: 2.3-2.8) and aspirin (100 mg/day). Propensity score (PS)
adjustment was used for statistical analysis. Two year survival was 65.4% (n = 134)
in the SR group and 51.3% (n = 60) in the AF group. The PS-adjusted hazard ratio
(HR) of 2 year mortality was higher in the AF group than in the SR group (HR = 1.48
[95% confidence interval (CI): 1.02-2.15; p = 0.038]). Right heart failure was a
more frequent cause of death in the AF group than in the SR group (p = 0.008). The
PS-adjusted odds ratio of perioperative RHF was for the AF group (reference: SR
group) 1.32 (95% CI: 0.80-2.18; p = 0.280). The PS-adjusted 2 year HRs of TE and
bleeding events were comparable between both groups and were for stroke, pump
thrombosis, and gastrointestinal bleeding (reference: SR group) 0.90 (95% CI: 0.53-
1.55; p = 0.714), 0.76 (95% CI: 0.14-4.31; p = 0.639), and 1.01 (95% CI: 0.60-1.70;
p = 0.978), respectively. Our data indicate that AF increases midterm mortality,
but does not influence the risk of stroke, pump thrombosis, and gastrointestinal
bleeding. The higher midterm mortality in AF patients is most likely disease-
related and should have no influence on LVAD implantation.
AD - From the *Department of Cardiothoracic Surgery, Heart and Diabetes Center
NRW, Ruhr University Bochum, Bad Oeynhausen, Germany; and †Department for Cardiac
Surgery, University of Innsbruck, Innsbruck, Austria.
AN - 28118262
AU - Oezpeker, C.
AU - Zittermann, A.
AU - Pühler, T.
AU - Ensminger, S.
AU - Gummert, J. F.
AU - Morshuis, M.
DA - Jul/Aug
DO - 10.1097/mat.0000000000000520
DP - NLM
ET - 2017/01/25
IS - 4
KW - Adult
Aged
Female
Gastrointestinal Hemorrhage/etiology
Humans
Male
Middle Aged
Propensity Score
Stroke/etiology
LA - eng
N1 - 1538-943x
Oezpeker, Cenk
Zittermann, Armin
Pühler, Thomas
Ensminger, Stephan
Gummert, Jan F
Morshuis, Michiel
Journal Article
United States
ASAIO J. 2017 Jul/Aug;63(4):419-424. doi: 10.1097/MAT.0000000000000520.
PY - 2017
SN - 1058-2916
SP - 419-424
ST - Permanent Atrial Fibrillation and 2 Year Clinical Outcomes in Patients with a
Left Ventricular Assist Device Implant
T2 - Asaio j
TI - Permanent Atrial Fibrillation and 2 Year Clinical Outcomes in Patients with a
Left Ventricular Assist Device Implant
VL - 63
ID - 2454
ER -
TY - JOUR
AB - BACKGROUND: The etiologies of ischemic stroke remain undetermined in 15% to
40% of patients. Apart from atrial fibrillation, other arrhythmias are less well-
characterized as risk factors. Premature cardiac contractions are known to confer
long-term cardiovascular risks, like myocardial infarction. Ischemic stroke as
cardiovascular risk outcome remains a topic of interest. We examined the
prospective relationships in the Atherosclerosis Risk in Communities (ARIC) study,
to determine whether premature atrial (PAC) or ventricular (PVC) contractions are
associated with increased risk for incident ischemic stroke. METHODS AND RESULTS:
We analyzed 14 493 baseline stroke-free middle-aged individuals in the ARIC public-
use data. The presence of PAC or PVC at baseline was assessed from 2-minute
electrocardiogram. A physician-panel confirmed and classified all stroke cases.
Average follow-up time was 13 years. Proportional hazards models assessed
associations between premature contractions and incident stroke. PACs and PVCs were
identified in 717 (4.9%) and 793 (5.5%) participants, respectively. In all,
509(3.5%) participants developed ischemic stroke. The hazard ratio (HR) (95%
confidence interval [CI]) associated with PVC was 1.77 (1.30, 2.41), attenuated to
1.25 (0.91, 1.71) after adjusting for baseline stroke risk factors. The interaction
between PVC and baseline hypertension was marginally significant (P=0.08). Among
normotensives, having PVCs was associated with nearly 2-fold increase in the rate
of incident ischemic stroke (HR 1.69; 95% CI 1.02, 2.78), adjusting for stroke risk
factors. The adjusted risk of ischemic stroke associated with PACs was 1.30 (95% CI
0.92, 1.83). CONCLUSIONS: Presence of PVCs may indicate an increased risk of
ischemic stroke, especially in normotensives. This risk approximates risk of stroke
from being black, male, or obese in normotensives from this cohort.
AD - Department of Critical Care Medicine, Mayo Clinic Rochester, MN 55905, USA.
ofoma.uchenna@mayo.edu
AN - 23316293
AU - Ofoma, U.
AU - He, F.
AU - Shaffer, M. L.
AU - Naccarelli, G. V.
AU - Liao, D.
C2 - PMC3541607
DA - Oct
DO - 10.1161/jaha.112.002519
DP - NLM
ET - 2013/01/15
IS - 5
KW - Electrocardiography
Female
Follow-Up Studies
Humans
Incidence
Male
Middle Aged
Risk
Risk Factors
Ventricular Premature Complexes/*epidemiology
brain ischemia
embolic stroke
premature atrial contraction
premature ventricular contraction
LA - eng
N1 - 2047-9980
Ofoma, Uchenna
He, Fan
Shaffer, Michele L
Naccarelli, Gerard V
Liao, Duanping
Journal Article
J Am Heart Assoc. 2012 Oct;1(5):e002519. doi: 10.1161/JAHA.112.002519. Epub 2012
Oct 25.
PY - 2012
SN - 2047-9980
SP - e002519
ST - Premature cardiac contractions and risk of incident ischemic stroke
TI - Premature cardiac contractions and risk of incident ischemic stroke
VL - 1
ID - 2361
ER -
TY - JOUR
AB - Purpose: The objective of this study was to test if combining antecedent
systolic blood pressure (SBP) with traditional risk factors and hypertension-
mediated organ damage (HMOD) improves risk stratification for subsequent
cardiovascular disease.Materials and methods: 1910 subjects participated in this
study. Antecedent SBP was defined as the average of measurements obtained in 1982
and in 1987. Current SBP was obtained in 1993. HMOD were examined in 1993. HMOD was
defined as either atherosclerotic plaque(s), increased pulse wave velocity,
increased urine albumin creatinine ratio (above the 90th percentile) or left
ventricular hypertrophy. Major adverse cardiovascular events (MACE) including
myocardial infarction, cerebrovascular disease, heart failure and arrhythmia were
obtained from national registries.Results: Subjects were divided into two age
categories: a middle-aged group (aged 41 or 51) and an older group (aged 61 or 71).
From 1993 to 2010, 425 events were observed. In multivariable analysis with both
current and antecedent SBP adjusted for traditional risk factors, current SBP was
associated with each measure of HMOD whilst antecedent SBP was not significantly
associated with urine albumin creatinine ratio in the older group, LVMI in the
middle-aged group, or the presence of plaque in any of the age groups (all p >
0.15). When current and antecedent SBP were evaluated together, current SBP was not
associated with MACE in the middle-aged subgroup [HR = 1.09 (0.96-1.22), p = 0.18]
but remained associated with MACE in the older subgroup [HR = 1.21 (1.10-1.34), p
< 0.01]. Contrariwise, antecedent SBP was only associated with MACE in the middle-
aged subgroup [HR = 1.24 (1.04-1.48), p = 0.02]. Adding antecedent SBP to
traditional risk factors did not improve the predictive accuracy of the survival
model.Conclusion: In healthy non-medicated middle-aged subjects, antecedent SBP is
associated with cardiovascular outcome independently of current BP, traditional
risk factors and HMOD. However, improvement in risk stratification seems to be
limited.
AD - Department of Internal Medicine, Kolding Hospital, Kolding, Denmark.
Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark.
Department of Cardiology, North Zealand Hospital, Hillerød, Denmark.
Department of Internal Medicine, Yale New Haven Hospital, Yale University School of
Medicine, New Haven, CT, USA.
Department of Clinical Physiology and Nuclear Medicine, Herlev Hospital, University
of Copenhagen, Copenhagen, Denmark.
Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital,
The Capital Region of Denmark, Copenhagen, Denmark.
Department of Cardiology, Rigshospitalet, University Hospital of Copenhagen,
Copenhagen, Denmark.
Centre for Individualized Medicine in Arterial Diseases (CIMA), Odense University
Hospital, Odense, University of Southern Denmark, Odense, Denmark.
Cardiology Section, Department of Internal Medicine, Holbæk Hospital, Holbæk,
Denmark.
AN - 32157916
AU - Olesen, T. B.
AU - Pareek, M.
AU - Stidsen, J. V.
AU - Blicher, M. K.
AU - Rasmussen, S.
AU - Vishram-Nielsen, J. K. K.
AU - Maagaard, L.
AU - M, H. Olsen
DA - Aug
DO - 10.1080/08037051.2020.1735930
DP - NLM
ET - 2020/03/12
IS - 4
J2 - Blood pressure
KW - Hypertension-mediated organ damage
aging
atherosclerosis
left ventricular hypertrophy
pulse wave velocity
risk stratification
LA - eng
N1 - 1651-1999
Olesen, Thomas B
Pareek, Manan
Stidsen, Jacob V
Blicher, Marie K
Rasmussen, Susanne
Vishram-Nielsen, Julie K K
Maagaard, Louise
H Olsen, Michael
Journal Article
England
Blood Press. 2020 Aug;29(4):232-240. doi: 10.1080/08037051.2020.1735930. Epub 2020
Mar 11.
PY - 2020
SN - 0803-7051
SP - 232-240
ST - Association between antecedent blood pressure, hypertension-mediated organ
damage and cardiovascular outcome
T2 - Blood Press
TI - Association between antecedent blood pressure, hypertension-mediated organ
damage and cardiovascular outcome
VL - 29
ID - 3133
ER -
TY - JOUR
AB - BACKGROUND: Often the underlying cause of cerebral ischemia (CI) cannot be
found during a routine diagnostic investigation, but paroxysmal atrial fibrillation
(PAF) could be the culprit. AIM: The objective of the study is to investigate
whether advanced echocardiography improves the diagnostic approach for PAF in CI.
METHODS: The study included 286 CI patients with an echocardiogram in sinus rhythm.
Patients were divided by PAF occurrence (PAF: n = 86, non-PAF: n = 200). PAF was
defined as 1 or more reported episodes of atrial fibrillation. Echocardiograms
consisted of conventional measures, tissue Doppler imaging (TDI), and speckle
tracking. TDI was performed to acquire myocardial peak velocities during
systole/ventricular contraction (global s'), early diastole/ventricular filling
(global e'), and late diastole/atrial contraction (global a'). Speckle tracking was
performed for myocardial strain analysis, thereby retrieving global longitudinal
strain and global strain rate (s, e, a) values. RESULTS: Patients with PAF
exhibited significantly impaired atrial contractile measures: global a' (-7.0
cm/second versus -5.7 cm/second, P < .001) and global strain rate a (.97 second(-1)
versus .81 second(-1), P < .001). Both were univariable markers of PAF, and along
with age remained the only independent significant determinants of PAF after
multivariable logistic regression. Area under the curve (AUC) for age, global a',
and global strain rate a significantly exceeded AUC for age alone (.79 versus .76,
P = .032). Cutoff values with the highest sensitivity and specificity for these 3
parameters improved the diagnostic accuracy (sensitivity = 97%, specificity = 32%,
negative predictive value = 95%, and positive predictive value = 38%). CONCLUSIONS:
Atrial contractile measures by advanced echocardiography are significant
determinants of PAF in CI. However, there is no discriminatory power to make them
clinically useful at the current moment.
AD - Department of Cardiology, Herlev Gentofte Hospital, University of Copenhagen,
Denmark. Electronic address: flemming.j.olsen@gmail.com.
Department of Cardiology, Herlev Gentofte Hospital, University of Copenhagen,
Denmark; Institute of Clinical Medicine, Faculty of Health and Medical Sciences,
University of Copenhagen, Copenhagen, Denmark.
Denmark.
Denmark; Department of Medicine, Cardiovascular Medicine Division, Brigham and
Women's Hospital, Harvard Medical School, Boston, Massachusetts.
AN - 26542824
AU - Olsen, F. J.
AU - Jørgensen, P. G.
AU - Møgelvang, R.
AU - Jensen, J. S.
AU - Fritz-Hansen, T.
AU - Bech, J.
AU - Biering-Sørensen, T.
DA - Feb
DP - NLM
ET - 2015/11/07
IS - 2
KW - Aged
Aged, 80 and over
Atrial Fibrillation/complications/*diagnostic imaging
Brain Ischemia/complications/*diagnostic imaging
Female
Humans
Male
Middle Aged
Ischemic stroke
atrial fibrillation
cardioembolic stroke
echocardiography
speckle tracking
LA - eng
N1 - 1532-8511
Olsen, Flemming Javier
Jørgensen, Peter Godsk
Møgelvang, Rasmus
Jensen, Jan Skov
Fritz-Hansen, Thomas
Bech, Jan
Biering-Sørensen, Tor
Journal Article
United States
10.1016/j.jstrokecerebrovasdis.2015.10.004. Epub 2015 Nov 2.
PY - 2016
SN - 1052-3057
SP - 350-9
ST - Predicting Paroxysmal Atrial Fibrillation in Cerebrovascular Ischemia Using
Tissue Doppler Imaging and Speckle Tracking Echocardiography
TI - Predicting Paroxysmal Atrial Fibrillation in Cerebrovascular Ischemia Using
Tissue Doppler Imaging and Speckle Tracking Echocardiography
VL - 25
ID - 2943
ER -
TY - JOUR
AB - Patients with acute myocardial infarction are at increased risk of developing
atrial fibrillation. We aimed to evaluate whether speckle tracking echocardiography
improves risk stratification for atrial fibrillation in these patients.The study
comprised of 373 patients with ST-segment elevation myocardial infarction (STEMI)
treated with primary percutaneous coronary intervention. Patients had an
echocardiogram performed at a median of 2 days after their STEMI. The
echocardiograms consisted of conventional measurements and myocardial strain
analysis by speckle tracking from 3 apical projections. The endpoint was a
composite of new-onset atrial fibrillation and ischemic stroke. At a median follow-
up time of 5.5 years (interquartile range 4.9, 6.1 years), 44 patients developed
the endpoint (atrial fibrillation: n = 24, ischemic stroke: n = 24, both: n = 4).
Patients who reached the endpoint had significantly reduced systolic function by
the left ventricular ejection fraction (LVEF) (43% vs 46%; P = 0.042) and global
longitudinal strain (10.9% vs 12.6%; P = 0.004), both being univariable predictors.
However, only global longitudinal strain remained a significantly independent
predictor (hazard ratio 1.12, 95% confidence interval 1.00; 1.25, P = 0.042, per 1%
decrease) after multivariable adjustment for baseline predictors (age, sex,
diabetes, hypertension, diastolic dysfunction, and LVEF) using Cox regression.
Furthermore, global longitudinal strain resulted in significantly higher c-
statistics for prediction of outcome compared with LVEF <45% (0.63 vs 0.52; P =
0.026). When stratified into tertiles of global longitudinal strain, it became
evident that patients in the lowest tertile mediated this signal with a 2-fold
increased risk compared with the highest tertile (hazard ratio 2.10, 95% confidence
interval 1.04; 4.25).Global longitudinal strain predicts atrial fibrillation after
STEMI and may add valuable information which can help facilitate arrhythmia
detection in these patients.
AD - aDepartment of Cardiology, Herlev & Gentofte Hospital, University of
Copenhagen, Copenhagen, DenmarkbDepartment of Medicine, Cardiovascular Medicine
Division, Brigham and Women's Hospital, Harvard Medical School, Boston,
MAcInstitute of Clinical Medicine, Faculty of Health and Medical Sciences,
University of Copenhagen, Copenhagen, Denmark.
AN - 27858918
AU - Olsen, F. J.
AU - Pedersen, S.
AU - Jensen, J. S.
C2 - PMC5591166
DA - Nov
DO - 10.1097/md.0000000000005338
DP - NLM
ET - 2016/11/20
IS - 44
J2 - Medicine
KW - Aged
*Echocardiography
Female
Humans
Male
Middle Aged
Myocardial Infarction/*complications/*diagnostic imaging
Prospective Studies
Stroke/*etiology
LA - eng
N1 - 1536-5964
Pedersen, Sune
Jensen, Jan Skov
Journal Article
Medicine (Baltimore). 2016 Nov;95(44):e5338. doi: 10.1097/MD.0000000000005338.
PY - 2016
SN - 0025-7974 (Print)
0025-7974
SP - e5338
ST - Global longitudinal strain predicts incident atrial fibrillation and stroke
occurrence after acute myocardial infarction
TI - Global longitudinal strain predicts incident atrial fibrillation and stroke
occurrence after acute myocardial infarction
VL - 95
ID - 2375
ER -
TY - JOUR
AB - OBJECTIVES: The purpose of this study was to evaluate the associations of
transthoracic echocardiographic parameters with recurrent atrial fibrillation (AF)
and/or stroke. BACKGROUND: The Atrial Fibrillation Follow-up Investigation of
Rhythm Management (AFFIRM) study, an evaluation of elderly patients with AF at risk
for stroke, provided an opportunity to evaluate the implications of
echocardiographic parameters in patients with AF. METHODS: Transthoracic
echocardiographic measures of mitral regurgitation (MR), left atrial (LA) diameter,
and left ventricular (LV) function were evaluated in the AFFIRM rate- and rhythm-
control patients who had sinus rhythm resume and had these data available. Risk for
recurrent AF or stroke was evaluated with respect to transthoracic
echocardiographic measures. RESULTS: Of 2,474 patients studied, 457 had > or
=2(+)/4(+) MR, and 726 had a LA diameter >4.5 cm. The LV ejection fraction was
abnormal in 543 patients. The cumulative probabilities of at least one AF
recurrence/stroke were 46%/1% after 1 year and 84%/5% by the end of the trial (> 5
years), respectively. Multivariate analysis showed that randomization to the
rhythm-control arm (hazard ratio [HR] = 0.64; p < 0.0001) and a qualifying episode
of AF being the first known episode (HR = 0.70; p < 0.0001) were associated with
decreased risk. Duration of qualifying AF episode >48 h (HR = 1.55; p < 0.0001) and
LA diameter (p = 0.008) were associated with an increased risk of recurrent AF.
Recurrent AF was more likely with larger LA diameters (HR = 1.21, 1.16, and 1.32
for mild, moderate, and severe enlargement, respectively). No transthoracic
echocardiographic measures were associated with risk of stroke. CONCLUSIONS: In the
AFFIRM study, large transthoracic echocardiographic LA diameters were associated
with recurrent AF, but no measured echocardiographic parameter was associated with
stroke.
AD - University of Iowa Hospitals, 200 Hawkins Drive, Iowa City, IA 52242, USA.
brian-olshansky@uiowa.edu
AN - 15963405
AU - Olshansky, B.
AU - Heller, E. N.
AU - Chandler, M.
AU - Slater, W.
AU - Green, M.
AU - Brodsky, M.
AU - Barrell, P.
AU - Greene, H. L.
DA - Jun 21
DO - 10.1016/j.jacc.2005.03.020
DP - NLM
ET - 2005/06/21
IS - 12
KW - Aged
Atrial Fibrillation/*diagnostic imaging/*etiology/therapy
Echocardiography
Female
Follow-Up Studies
Humans
Male
Middle Aged
Mitral Valve Insufficiency/*complications/diagnostic imaging
Recurrence
Risk Factors
Stroke/*etiology
LA - eng
N1 - Olshansky, Brian
Heller, Eliot N
Mitchell, L Brent
Chandler, Mary
Slater, William
Green, Martin
Brodsky, Michael
Barrell, Patrick
Greene, H Leon
N01 HC 55139/HC/NHLBI NIH HHS/United States
Journal Article
United States
J Am Coll Cardiol. 2005 Jun 21;45(12):2026-33. doi: 10.1016/j.jacc.2005.03.020.
PY - 2005
SN - 0735-1097 (Print)
0735-1097
SP - 2026-33
ST - Are transthoracic echocardiographic parameters associated with atrial
fibrillation recurrence or stroke? Results from the Atrial Fibrillation Follow-Up
Investigation of Rhythm Management (AFFIRM) study
TI - Are transthoracic echocardiographic parameters associated with atrial
fibrillation recurrence or stroke? Results from the Atrial Fibrillation Follow-Up
Investigation of Rhythm Management (AFFIRM) study
VL - 45
ID - 2541
ER -
TY - JOUR
AB - Anderson-Fabry disease is a rare X-linked lysosomal storage disorder caused
by mutations of the GLA gene that encodes alpha-galactosidase A. The ensuing enzyme
deficiency results in intracellular accumulation of neutral glycosphingolipids
(primarily globotriaosylceramide) and progressive renal, cardiac, and
cerebrovascular disease. Female carriers are at risk of developing disease, but
this tends to be milder and more slowly progressive than in males. Left ventricular
hypertrophy is the most common cardiac manifestation followed by conduction system
disease, valve dysfunction, and arrhythmias. Management of cardiovascular symptoms
and the prevention of complications rely on conventional pharmacologic and device-
based therapies, but data on the effect of enzyme replacement therapy suggest that
it has the potential to attenuate and possibly reverse some aspects of cardiac
involvement.
AD - Inherited Cardiac Diseases Unit, The Heart Hospital, University College
London, UK.
AN - 20109602
AU - O'Mahony, C.
AU - Elliott, P.
DA - Jan-Feb
DO - 10.1016/j.pcad.2009.11.002
DP - NLM
ET - 2010/01/30
IS - 4
J2 - Progress in cardiovascular diseases
KW - Adult
Arrhythmias, Cardiac/genetics
Diagnostic Imaging
Disease Progression
Enzyme Replacement Therapy
Fabry Disease/complications/diagnosis/enzymology/epidemiology/*genetics/therapy
Female
Genetic Predisposition to Disease
Heart Diseases/diagnosis/enzymology/epidemiology/*genetics/prevention &
control/therapy
Heart Valve Diseases/genetics
Humans
Hypertrophy, Left Ventricular/genetics
Male
Middle Aged
*Mutation
Risk Factors
Sex Factors
Treatment Outcome
alpha-Galactosidase/*genetics/metabolism/therapeutic use
LA - eng
N1 - 1873-1740
O'Mahony, Constantinos
Elliott, Perry
Journal Article
Review
United States
Prog Cardiovasc Dis. 2010 Jan-Feb;52(4):326-35. doi: 10.1016/j.pcad.2009.11.002.
PY - 2010
SN - 0033-0620
SP - 326-35
ST - Anderson-Fabry disease and the heart
T2 - Prog Cardiovasc Dis
TI - Anderson-Fabry disease and the heart
VL - 52
ID - 3056
ER -
TY - JOUR
AB - AIMS: To determine if the association between electrocardiographic left
ventricular hypertrophy (ECG-LVH) and ischaemic stroke is partially explained by
the concomitant presence of QT prolongation. METHODS AND RESULTS: A total of 24 948
(mean age = 65 ± 9.4 years; 40% black; 55% women) participants from the REasons for
Geographic And Racial Differences in Stroke (REGARDS) study were included in this
analysis. Electrocardiographic left ventricular hypertrophy was defined by the
Sokolow-Lyon criteria. Heart rate-adjusted QT (QTa) was computed using a linear
regression model. Adjudicated ischaemic stroke events were the outcome of interest.
Cox regression was used to compute hazard ratios (HRs) and 95% confidence intervals
(CIs) for associations between ECG-LVH and prolonged QTa, in isolation and
combined, with ischaemic stroke. There were 2422 (9.7%) participants with ECG-LVH,
820 (3.3%) with prolonged QTa, and 161 (0.6%) with both. Over a median follow-up of
7.6 years, 714 (2.9%) ischaemic stroke events occurred. After adjustment for stroke
risk factors and potential confounders, an increased risk of ischaemic stroke was
observed among participants with ECG-LVH and prolonged QTa (HR = 1.85, 95% CI =
1.04-3.30), isolated ECG-LVH (HR = 1.40, 95% CI = 1.13-1.75), and isolated
prolonged QTa (HR = 1.45, 95% CI = 1.04-2.03) compared with participants without
either condition. When ECG-LVH and prolonged QTa were examined as separate
variables, the risk of ischaemic stroke for each condition remained statistically
significant. CONCLUSION: The combination of ECG-LVH and prolonged QT is associated
with a higher risk of ischaemic stroke compared with either condition in isolation,
and the stroke risk for each condition does not depend on the presence of the
other.
AD - Department of Internal Medicine, Wake Forest School of Medicine, Winston-
Salem, NC, USA woneal@wakehealth.edu.
Department of Epidemiology, School of Public Health, University of Alabama at
Birmingham, Birmingham, AL, USA.
Department of Neurology, University of Cincinnati, Cincinnati, OH, USA.
Department of Biostatistics, School of Public Health, University of Alabama at
Birmingham, Birmingham, AL, USA.
Department of Medicine, University of Vermont, Burlington, VT, USA.
Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC,
USA Epidemiological Cardiology Research Center (EPICARE), Department of
Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC,
USA.
AN - 26487665
AU - O'Neal, W. T.
AU - Howard, V. J.
AU - Kissela, B.
AU - Judd, S. E.
AU - McClure, L. A.
AU - Cushman, M.
AU - Howard, G.
AU - Soliman, E. Z.
C2 - PMC4880112
DA - May
DO - 10.1093/europace/euv232
DP - NLM
ET - 2015/10/22
IS - 5
KW - Aged
Arrhythmias, Cardiac/*epidemiology/*physiopathology
Electrocardiography
Female
Heart Rate
Humans
Hypertrophy, Left Ventricular/*epidemiology/*physiopathology
Linear Models
Male
Middle Aged
Risk Factors
Stroke/*epidemiology/*physiopathology
United States
QT interval
Stroke
LA - eng
N1 - 1532-2092
O'Neal, Wesley T
Howard, Virginia J
Kleindorfer, Dawn
Kissela, Brett
Judd, Suzanne E
McClure, Leslie A
Cushman, Mary
Howard, George
Soliman, Elsayed Z
P30 DK079626/DK/NIDDK NIH HHS/United States
Journal Article
Multicenter Study
Europace. 2016 May;18(5):767-72. doi: 10.1093/europace/euv232. Epub 2015 Oct 20.
PY - 2016
SN - 1099-5129 (Print)
1099-5129
SP - 767-72
ST - Interrelationship between electrocardiographic left ventricular hypertrophy,
QT prolongation, and ischaemic stroke: the REasons for Geographic and Racial
Differences in Stroke Study
T2 - Europace
TI - Interrelationship between electrocardiographic left ventricular hypertrophy,
QT prolongation, and ischaemic stroke: the REasons for Geographic and Racial
Differences in Stroke Study
VL - 18
ID - 2366
ER -
TY - JOUR
AB - BACKGROUND: Non-vitamin K antagonist oral anticoagulants (NOACs) have been
widely used to prevent stroke in non-valvular atrial fibrillation (NVAF) patients.
Stringent monitoring is not required for NOACs, albeit dose adjustments are needed
based on specific patient factors, such as renal function, body weight and age, or
concomitant medications. We investigated the NOAC dosing patterns and evaluated the
predictors of the non-standardized dose reduction (NSDR). METHODS: A total of 2452
newly diagnosed NVAF patients were consecutively recruited from secondary- and
tertiary-care hospitals between 2012 and 2017. The NOAC doses were classified as
one of three: (1) full dose; (2) standardized dose reduction (SDR); or (3) NSDR,
consistent with Japanese package inserts. RESULTS: Overall, 66.8% (N=1637) of the
NVAF patients (median age: 69 years, interquartile range [IQR]: 60-76; 70% male;
median CHA(2)DS(2)-VASc score of 2, IQR: 1-3) received NOACs. NOAC use dramatically
increased during the study period (51.2% in 2012-13 to 74.4% in 2016-17). The
percentages of SDR and NSDR were 19.6% and 14.4%, respectively; a proportion of SDR
and NSDR did not alter drastically. Older age, concomitant antiplatelet therapy,
impaired renal function, and prior heart failure or left ventricular dysfunction
were independently associated with NSDR. Of note, patients with a high risk
(CHA(2)DS(2)-VASc score ≥2) had the highest proportion of NSDRs. CONCLUSIONS:
Nearly half of the NOAC dose reductions in our registry were deemed "non-
standardized," which were seen mostly in patients at significant risk for ischemic
stroke. The physician's apprehension regarding excessive bleeding under NOAC use
should be appropriately balanced with concern for an increased risk of embolic
events.
AD - Department of Cardiology, National Hospital Organization Saitama National
Hospital, Saitama, Japan.
Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.
Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.
Electronic address: sk@keio.jp.
AN - 30487057
AU - Ono, T.
AU - Ikemura, N.
AU - Kimura, T.
AU - Ueda, I.
AU - Tanaka, H.
AU - Tokuda, H.
AU - Yajima, N.
AU - Matsumura, K.
AU - Suzuki, M.
AU - Fukuda, K.
AU - Kohsaka, S.
AU - Takatsuki, S.
DA - Jan
DO - 10.1016/j.jjcc.2018.09.003
DP - NLM
ET - 2018/11/30
IS - 1
Aged
Female
Humans
Japan
Male
Middle Aged
Registries
Time Factors
*Non-vitamin K antagonist oral anticoagulant
LA - eng
N1 - 1876-4738
Ono, Tomohiko
Ikemura, Nobuhiro
Kimura, Takehiro
Ueda, Ikuko
Tanaka, Hiroaki
Tokuda, Hanako
Yajima, Noriyuki
Matsumura, Keisuke
Suzuki, Masahiro
Fukuda, Keiichi
Kohsaka, Shun
Takatsuki, Seiji
Evaluation Study
Journal Article
Multicenter Study
Netherlands
J Cardiol. 2019 Jan;73(1):14-21. doi: 10.1016/j.jjcc.2018.09.003. Epub 2018 Oct 25.
PY - 2019
SN - 0914-5087
SP - 14-21
ST - Contemporary trend of reduced-dose non-vitamin K anticoagulants in Japanese
patients with atrial fibrillation: A cross-sectional analysis of a multicenter
outpatient registry
T2 - J Cardiol
TI - Contemporary trend of reduced-dose non-vitamin K anticoagulants in Japanese
patients with atrial fibrillation: A cross-sectional analysis of a multicenter
outpatient registry
VL - 73
ID - 2442
ER -
TY - JOUR
AB - BACKGROUND: Patients with atrial fibrillation (AF) can be managed either by
maintaining sinus rhythm using antiarrhythmic drugs and/or electrical
cardioversion, or by leaving patients in AF and controlling ventricular rate
without attempts to restore sinus rhythm. Which of these two strategies is
superior, has not yet been definitively established. AIM: HOT CAFE Polish Study
(How To Treat Chronic Atrial Fibrillation) was designed to evaluate in a
randomised, multicentre and prospective manner the risks and advantages of two
therapeutical strategies - rate control or rhythm control, in patients with
persistent AF. METHODS: The study group consisted of 205 patients (71 females and
134 males; mean age 60.8+/-11.2 years) with a mean time of AF duration of 273.7+/-
112.4 days; 101 patients were randomly assigned to rate control (Group I) whereas
104 patients were randomised to sinus rhythm (SR) restoration by DC cardioversion
(CV) and subsequent antiarrhythmic drug treatment (Group II). At the end of follow-
up (12 months) SR was present in 75% of patients. RESULTS: The incidence of
hospital admissions was higher in group II in comparison to group I (12% vs 74%;
p<0.001). Mortality was similar in both groups (1.0% versus 2.9%, NS). In both
groups a significant improvement of heart failure symptoms was observed during the
first 2 months (p<0.02 and p<0.001). In group II exercise tolerability measured by
maximal workload during treadmill test significantly improved compared with
baseline (5.2+/-5.1 vs 7.6+/-3.3 MET; p<0.0001). In patients in whom SR was
restored, the left ventricular function improved and an increase in the shortening
fraction was observed (29+/-7% vs 31+/-7%; p<0.01). No thromboembolic complications
were observed in patients left with AF. Three patients from group II suffered
ischaemic stroke; in two cases stroke was associated with CV whereas in the third
patient - with late AF recurrence. CONCLUSIONS: The HOT CAFE Polish Study did not
reveal significant differences in mortality between the two treatment strategies in
patients with persistent AF. Although patients with SR had better improvement in
some haemodynamical parameters, the hospitalisation rate was higher and the
incidence of stroke was not reduced compared with the rate control group.
AD - Chair and Department of Internal Medicine and Cardiology, Medical Academy,
Warsaw, Poland.
AN - 14560344
AU - Opolski, G.
AU - Torbicki, A.
AU - Kosior, D.
AU - Szulc, M.
AU - Zawadzka, M.
AU - Pierścińska, M.
AU - Kołodziej, P.
AU - Stopiński, M.
AU - Wozakowska-Kapłon, B.
AU - Achremczyk, P.
AU - Rabczenko, D.
DA - Jul
DP - NLM
ET - 2003/10/16
IS - 7
KW - Aged
Anti-Arrhythmia Agents/pharmacology/*therapeutic use
Chronic Disease
Electric Countershock/*methods
Female
Heart Conduction System/drug effects/*physiopathology
Hemodynamics
Humans
Length of Stay
Male
Middle Aged
Prospective Studies
Time Factors
LA - eng
N1 - Opolski, Grzegorz
Torbicki, Adam
Kosior, Dariusz
Szulc, Marcin
Zawadzka, Maria
Pierścińska, Magdalena
Kołodziej, Piotr
Stopiński, Marek
Wozakowska-Kapłon, Beata
Achremczyk, Piotr
Rabczenko, Daniel
Clinical Trial
Journal Article
Multicenter Study
Poland
Kardiol Pol. 2003 Jul;59(7):1-16; discussion 15-16.
PY - 2003
SN - 0022-9032 (Print)
0022-9032
SP - 1-16; discussion 15-16
ST - Rhythm control versus rate control in patients with persistent atrial
fibrillation. Results of the HOT CAFE Polish Study
T2 - Kardiol Pol
TI - Rhythm control versus rate control in patients with persistent atrial
fibrillation. Results of the HOT CAFE Polish Study
VL - 59
ID - 2600
ER -
TY - JOUR
AB - The revised practice guideline 'Atrial fibrillation' from the Dutch College
of General Practitioners provides the general practitioner with guidelines for
diagnosis and management of patients with atrial fibrillation. To find patients
with atrial fibrillation, it is advised to check cardiac rhythm at every blood
pressure measurement. In patients over 65 years old, acceptance of atrial
fibrillation with control of ventricular rate is preferred to sinus rhythm
normalisation. In therapy with beta-blockers, slow release metoprolol is the drug
of choice. An important goal of treatment is the prevention of thrombo-embolic
complications. The choice between anticoagulants such as aspirin and coumarin
derivatives is based on the CHADS2 score and determined by age (above 75 years) and
comorbidity including cardiac failure, diabetes, hypertension, and previous
transient ischaemic attack (TIA) or cardiovascular accident (CVA). The adequacy of
antithrombotic treatment should be reassessed yearly.
AD - Nederlands Huisartsen Genootschap, afd. Richtlijnontwikkeling en Wetenschap,
Utrecht, the Netherlands. w.opstelten@nhg.org
AN - 21029493
AU - Opstelten, W.
AU - Boode, B. S.
AU - Heeringa, J.
AU - Rutten, F. H.
AU - Goudswaard, A. N.
DP - NLM
ET - 2010/10/30
KW - Age Factors
Atrial Fibrillation/*diagnosis/*therapy
General Practice/*standards
Humans
Metoprolol/therapeutic use
Netherlands
*Practice Guidelines as Topic
*Practice Patterns, Physicians'
LA - dut
N1 - 1876-8784
Opstelten, Wim
Boode, Bep S P
Heeringa, Jan
Rutten, Frans H
Goudswaard, A N Lex
English Abstract
Journal Article
Netherlands
Ned Tijdschr Geneeskd. 2010;154:A1570.
OP - Samenvatting van de standaard 'Atriumfibrilleren' (eerste herziening) van het
Nederlands Huisartsen Genootschap.
PY - 2010
SN - 0028-2162
SP - A1570
ST - [Summary of the practice guideline 'Atrial fibrillation' (first revision)
from the Dutch College of General Practitioners]
TI - [Summary of the practice guideline 'Atrial fibrillation' (first revision)
from the Dutch College of General Practitioners]
VL - 154
ID - 2819
ER -
TY - JOUR
AB - In recent years, several types of centrifugal pumps have been widely used as
the main pumps for cardiopulmonary bypass (CPB) and postcardiotomy cardiac support.
From April 1990 to March 1997, a percutaneous cardiopulmonary support (PCPS) system
was used in 20 patients with an average age of 58 years (13 males and 7 females).
They comprised 11 ischemic, 6 valvular, 2 aortic, and 1 congenital heart disease
patients. Our PCPS system consists of a centrifugal pump (BioMedicus BP-80), an
oxygenator, and a reservoir. The entire blood contacting surface, including that of
the thin wall cannulas, is coated by heparin bonded materials. As a result of this
new technology, this system can be used for the long term without systemic
heparinization. No major critical thrombi were revealed inside the pumps or
circuits. Of the 20 patients, 7 (35%) (Group 1) could be weaned from PCPS, and the
remaining 13 (Group 2) could not. In Group 1 although 2 patients suffered from
renal failure and pneumonia, respectively, both were discharged from our hospital.
The long-term survival rate was 35%. In Group 2 cerebral vascular damage was
recognized in 3 patients, renal failure in 4, multiple system organ failure in 4,
bleeding in 2, arrhythmia in 1, and leg ischemia in 2. Pulse pressure was
significantly elevated due to the recovery of the native heart in Group 1, 2 days
after support. However, in Group 2, it did not elevate, and the left ventricular
ejection fraction was less than 30%, associated with high left atrial pressure. In
conclusion, this heparin coated PCPS system was very simple and easy to control. It
demonstrated long-term biocompatibility and was very effective in recovering
deteriorated cardiac function. Quicker application of this system can play an
important role in preventing severe complications and obtaining better clinical
results. If long-term support is necessary, a ventricular assist device (VAD),
which is more powerful, durable, and biocompatible, has to be applied instead of
PCPS.
AD - The Second Department Surgery, Nihon University School of Medicine, Tokyo,
Japan.
AN - 9650672
AU - Orime, Y.
AU - Shiono, M.
AU - Hata, H.
AU - Yagi, S.
AU - Tsukamoto, S.
AU - Okumura, H.
AU - Nakata, K.
AU - Kimura, S.
AU - Sezai, A.
AU - Sezai, Y.
DA - Jun
DO - 10.1046/j.1525-1594.1998.06136.x
DP - NLM
ET - 1998/07/03
IS - 6
J2 - Artificial organs
KW - Acute Kidney Injury/complications
Aged
Aortic Diseases/surgery
Assisted Circulation/instrumentation
Biocompatible Materials
Cardiopulmonary Bypass/instrumentation
Catheterization/instrumentation
Cerebrovascular Disorders/complications
Female
Heart Defects, Congenital/surgery
*Heart, Artificial
Hemorrhage/complications
Humans
Ischemia/complications
Leg/blood supply
Male
Middle Aged
Multiple Organ Failure/complications
Myocardial Ischemia/surgery
Oxygenators
Patient Discharge
Pneumonia/complications
Prosthesis Design
Stroke Volume
Survival Rate
LA - eng
N1 - Orime, Y
Shiono, M
Hata, H
Yagi, S
Tsukamoto, S
Okumura, H
Nakata, K
Kimura, S
Sezai, A
Sezai, Y
Journal Article
United States
Artif Organs. 1998 Jun;22(6):498-501. doi: 10.1046/j.1525-1594.1998.06136.x.
PY - 1998
SN - 0160-564X (Print)
0160-564x
SP - 498-501
ST - Clinical experiences of percutaneous cardiopulmonary support: its
effectiveness and limit
T2 - Artif Organs
TI - Clinical experiences of percutaneous cardiopulmonary support: its
effectiveness and limit
VL - 22
ID - 2989
ER -
TY - JOUR
AB - AIMS: The objectives of this study were to determine the long-term outcome
and the predictors of adverse events in patients originally diagnosed with lone
atrial fibrillation (AF). METHODS AND RESULTS: This population-based historical
cohort study comprised 46 residents of Olmsted County, MN, USA, with well-
documented, clinically defined lone AF and a complete two-dimensional
echocardiographic examination. The original echocardiographic videotape recordings
were analysed in a blinded fashion for left atrial volume (LAV) and left
ventricular ejection fraction. With 1296 person-years of follow-up, the median
duration of AF was 27 (first quartile=24, third quartile=33) years. Twenty-three
(50%) patients developed events. Cerebral infarction occurred in seven patients,
myocardial infarction in 11, and congestive heart failure in 16. In a multivariable
analysis, patients with indexed LAV >or=32 mL/m(2) had a significantly worse event-
free survival (adjusted HR, 4.46; 95% CI, 1.56-12.74; P=0.005). All cerebral
infarctions occurred in patients with an indexed LAV >32 mL/m(2). CONCLUSION:
Patients originally diagnosed with benign lone AF follow divergent courses based on
LAV. Those originally diagnosed with lone AF and normal sized atria had a benign
clinical course throughout the long-term follow-up. Patients with increased LAV at
diagnosis or later during the follow-up experienced adverse events.
AD - Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW,
Rochester, MN 55905, USA.
AN - 16141257
AU - Osranek, M.
AU - Bursi, F.
AU - Bailey, K. R.
AU - Grossardt, B. R.
AU - Brown, R. D., Jr.
AU - Kopecky, S. L.
AU - Tsang, T. S.
AU - Seward, J. B.
DA - Dec
DO - 10.1093/eurheartj/ehi483
DP - NLM
ET - 2005/09/06
IS - 23
KW - Aged
Aged, 80 and over
Atrial Fibrillation/complications/mortality/*physiopathology
Cardiac Volume
Cardiovascular Diseases/etiology/mortality
Heart Atria/diagnostic imaging/pathology
Humans
Middle Aged
Prognosis
Stroke/mortality
Ultrasonography
LA - eng
N1 - Osranek, Martin
Bursi, Francesca
Bailey, Kent R
Grossardt, Brandon R
Brown, Robert D Jr
Kopecky, Stephen L
Tsang, Teresa S
Seward, James B
Journal Article
England
Eur Heart J. 2005 Dec;26(23):2556-61. doi: 10.1093/eurheartj/ehi483. Epub 2005 Sep
1.
PY - 2005
SN - 0195-668X (Print)
0195-668x
SP - 2556-61
ST - Left atrial volume predicts cardiovascular events in patients originally
diagnosed with lone atrial fibrillation: three-decade follow-up
T2 - Eur Heart J
TI - Left atrial volume predicts cardiovascular events in patients originally
diagnosed with lone atrial fibrillation: three-decade follow-up
VL - 26
ID - 2666
ER -
TY - JOUR
AB - The influence of arrhythmias on cerebral function was investigated in 8
patients with sick sinus syndrome (bradycardia tachycardia syndrome) and 8 patients
with advanced or complete atrioventricular block using 24-hour continuous
recordings of the electrocardiogram and conventional electroencephalogram
recordings. Syncope was observed more frequently in the atrio-ventricular block
group, and was observed frequently when the longest heart beat pause during a 24-
hour day was longer than 2.2 sec. Cerebral infarction as a complication of these
arrhythmias was observed only with the sick sinus syndrome group. The maximum heart
rate during a 24-hour day and the difference between maximum and minimum heart rate
were significantly lower in the atrioventricular block group than in the sick sinus
syndrome group. The electroencephalogram results showed a slight slowing of the
background activity and the appearance of slow wave bursts in both groups. These
abnormal findings were improved during intracardiac pacing in the atrio-ventricular
block group. A quantitative analysis of the frequency of the electroencephalogram
at various heart rates demonstrated the optimum pacing rate for the cerebral
function. These results suggest that both the cerebral function and the cardiac
function must be considered in the treatment of patients with bradycardia
arrhythmias.
AN - 7131778
AU - Otsuka, K.
AU - Yanaga, T.
AU - Ichimaru, Y.
AU - Seto, K.
DA - Jul
DO - 10.1536/ihj.23.469
DP - NLM
ET - 1982/07/01
IS - 4
J2 - Japanese heart journal
KW - Adult
Aged
Arrhythmias, Cardiac/*physiopathology
Brain/*physiopathology
Female
Heart Block/*physiopathology
Heart Rate
Humans
Male
Middle Aged
Sick Sinus Syndrome/*physiopathology
LA - eng
N1 - Otsuka, K
Yanaga, T
Ichimaru, Y
Seto, K
Comparative Study
Journal Article
Japan
Jpn Heart J. 1982 Jul;23(4):469-78. doi: 10.1536/ihj.23.469.
PY - 1982
SN - 0021-4868 (Print)
0021-4868
SP - 469-78
ST - Observations of the effect of arrhythmias on the cerebral function by
recordings of 24-hour continuous electrocardiograms. Comparison between the sick
sinus syndrome and atrio-ventricular block
T2 - Jpn Heart J
TI - Observations of the effect of arrhythmias on the cerebral function by
recordings of 24-hour continuous electrocardiograms. Comparison between the sick
sinus syndrome and atrio-ventricular block
VL - 23
ID - 2430
ER -
TY - JOUR
AB - INTRODUCTION: Fabry's disease is an infrequent metabolic pathology linked to
the X chromosome which causes a wide variety of signs and symptoms. CASE REPORT: A
39-year-old male who was admitted to our stroke unit with right-side hemiparesis (1
+ 0) and dysarthria (1). The score on the National Institute of Health Stroke Scale
was 2. The patient presented angiokeratomas in both thighs. A computerised axial
tomography scan of the head showed left thalamic acute infarction. The duplex scan
of the supra-aortic trunks was normal, and the transcranial Doppler reflected a
generalised increase in the pulsatility indices. Transthoracic echocardiography
showed left ventricular hypertrophy and left atrial dilatation. He was discharged
five days later, with antiaggregating medication but asymptomatic. The prolonged
Holter-electrocardiogram recording showed paroxysmal atrial fibrillation. One
notable value in the urine analysis was microalbuminuria of 281 mg/L. In view of
the multi-organic involvement and the family history, a study for Fabry's disease
was performed. Activity of the enzyme alpha-galactosidase A was diminished, and the
presence of a mutation in the GLA gene was found. The patient's brother, who
suffered from kidney failure and atrial fibrillation, was positive for this
mutation. The patient is on treatment with agalsidase beta. CONCLUSIONS: Fabry's
disease must be suspected in young males with heart disease, stroke or peripheral
neuropathy, skin lesions, kidney failure and a history of cases in the family.
Hormone replacement therapy must be established at an early stage, as it can
improve the prognosis.
AD - Hospital Universitario de Torrejon, Torrejon de Ardoz, Espana.
AN - 28497441
AU - Oyanguren, B.
AU - Segoviano, R.
AU - Alegria, E.
AU - Besada, E.
AU - Gonzalez-Salaices, M.
AU - Eimil-Ortiz, M.
AU - Lopez de Silanes, C.
DA - May 16
DP - NLM
ET - 2017/05/13
IS - 10
J2 - Revista de neurologia
KW - Adult
Algorithms
Cerebral Infarction/*etiology
Child
Dysarthria/etiology
Enzyme Replacement Therapy
Fabry Disease/*complications/diagnosis/drug therapy/genetics
Family Health
Female
Humans
Kidney Failure, Chronic/etiology
Male
Middle Aged
Mutation
Paresis/etiology
Thalamus/*blood supply
alpha-Galactosidase/genetics/therapeutic use
LA - spa
N1 - 1576-6578
Oyanguren, B
Segoviano, R
Alegria, E
Besada, E
Gonzalez-Salaices, M
Eimil-Ortiz, M
Lopez de Silanes, C
Case Reports
Journal Article
Spain
Rev Neurol. 2017 May 16;64(10):454-458.
OP - Ictus criptogenico en un paciente joven con cardiopatia y fallo renal.
PY - 2017
SN - 0210-0010
SP - 454-458
ST - [Cryptogenic stroke in a young patient with heart disease and kidney failure]
T2 - Rev Neurol
TI - [Cryptogenic stroke in a young patient with heart disease and kidney failure]
VL - 64
ID - 3032
ER -
TY - JOUR
AB - BACKGROUND: The index of cardioelectrophysiological balance (iCEB), measured
as QT interval divided by QRS duration, has recently been defined as a new risk
marker for arrhythmias. Increased or decreased iCEB is associated with malignant
ventricular arrhythmias. AIM: In this study, we aimed to investigate the
relationship between iCEB and stroke severity in patients with acute ischemic
stroke. METHODS: The study comprised 105 adult patients (males, 58; females, 47; 69
± 15 years) with acute ischemic stroke. Nine patients were excluded. Patients were
divided into two groups based on the calculated National Institutes of Health
Stroke Scale (NIHSS) score (Group 1, NIHSS score <16; Group 2, NIHSS score ≥16).
Demographic, clinical, and laboratory data for all patients were collected.
Electrocardiography (ECG) was recorded from all patients on admission to the
neurology care unit. iCEB (QT/QRS) was calculated from the 12-lead
electrocardiogram. RESULTS: There were no significant differences among the
demographic parameters of patients. iCEB score was significantly higher in Group 2
patients than Group 1 patients (3.97 ± 0.61 vs 3.43 ± 0.57, P = 0.0024).
CONCLUSION: Our results suggested that iCEB is associated with stroke severity on
admission in patients with acute ischemic stroke. It is known that high iCEB is
associated with torsade de pointes (TdP), ventricular tachycardia.
AD - Department of Neurology, University of Health Sciences, Diyarbakir Gazi
Yasargil Education and Research Hospital, Diyarbakir, Turkey.
Department of Cardiology, University of Health Sciences, Diyarbakir Gazi Yasargil
Education and Research Hospital, Diyarbakir, Turkey.
AN - 32525110
AU - Ozturk, U.
AU - Ozturk, O.
DA - Jun
DO - 10.4103/njcp.njcp_505_19
DP - NLM
ET - 2020/06/12
IS - 6
J2 - Nigerian journal of clinical practice
KW - Adult
Aged
Aged, 80 and over
Arrhythmias, Cardiac/complications/*diagnosis
Brain Ischemia/*diagnosis
Female
Humans
Male
Middle Aged
Prospective Studies
Stroke/complications/*diagnosis
Arrhythmia
Ecg
Index of Cardioelectrophysiological Balance
stroke
LA - eng
N1 - Ozturk, U
Ozturk, O
Journal Article
India
Niger J Clin Pract. 2020 Jun;23(6):768-774. doi: 10.4103/njcp.njcp_505_19.
PY - 2020
SN - 1119-3077 (Print)
SP - 768-774
ST - Relation between index of cardioelectrophysiological balance and stroke
severity in patients with acute ischemic stroke
T2 - Niger J Clin Pract
TI - Relation between index of cardioelectrophysiological balance and stroke
severity in patients with acute ischemic stroke
VL - 23
ID - 2474
ER -
TY - JOUR
AB - BACKGROUND: Atrial fibrillation (AF) affects 1.5-2% of the population and is
associated with a five-fold increased lifetime risk of stroke [1]. The left atrial
appendage (LAA) is the source of embolic strokes in up to 90% of patients with non-
valvular AF with clots in the left atrium [2]. METHODS: We reviewed the clinical
notes and echocardiographic findings of 20 patients who underwent open cardiac
surgery in which concurrent AtriClip (Atricure Inc, Westchester, OH, USA) device
insertion was attempted at our institution from July 2013 to February 2015. This
was to examine the safety and efficacy of LAA exclusion with clip devices during
open cardiac surgery. Indications for LAA exclusion included a history or suspicion
of atrial arrhythmia, left ventricular dilatation, or a history of transient
ischaemic attacks. RESULTS: All 20 of the 20 participants had successful placement
of the clip device (100% success rate). There were no adverse events related to the
device and no perioperative mortality. There were three late deaths due to chronic
obstructive pulmonary disease (COPD), leukaemia, and refractory congestive cardiac
failure. No late device related complications were found on follow-up imaging in
the remaining patients. CONCLUSIONS: The results of our study demonstrate the LAA
exclusion during open cardiac surgery with the AtriClip device is safe, has a 100%
success rate, and appears to be stable over time.
AD - Department of Cardiothoracic Surgery, St Vincent's Hospital, Melbourne, Vic,
Australia. Electronic address: sm.page@bigpond.com.
Department of Cardiothoracic Surgery, St Vincent's Hospital, Melbourne, Vic,
Australia.
Department of Anaesthesia, St Vincent's Hospital, Melbourne, Vic, Australia.
AN - 29402693
AU - Page, S.
AU - Hallam, J.
AU - Pradhan, N.
AU - Cowie, B.
AU - Phan, T.
AU - McGlade, D.
AU - Rosalion, A.
AU - Newcomb, A.
AU - Yii, M.
DA - Mar
DO - 10.1016/j.hlc.2017.12.006
DP - NLM
ET - 2018/02/07
IS - 3
KW - Aged
Aged, 80 and over
Atrial Fibrillation/diagnosis/physiopathology/*surgery
Cardiac Surgical Procedures/*instrumentation
Equipment Design
Female
Follow-Up Studies
Humans
Male
Middle Aged
Surgical Instruments
Treatment Outcome
Atrial fibrillation
Left atrial appendage
LA - eng
N1 - 1444-2892
Page, Sarah
Hallam, Jane
Pradhan, Neelprada
Cowie, Brian
Phan, Tuong
McGlade, Desmond
Rosalion, Alex
Newcomb, Andrew
Yii, Michael
Journal Article
Australia
Heart Lung Circ. 2019 Mar;28(3):430-435. doi: 10.1016/j.hlc.2017.12.006. Epub 2017
Dec 22.
PY - 2019
SN - 1443-9506
SP - 430-435
ST - Left Atrial Appendage Exclusion Using the AtriClip Device: A Case Series
TI - Left Atrial Appendage Exclusion Using the AtriClip Device: A Case Series
VL - 28
ID - 2436
ER -
TY - JOUR
AB - Although the literature has failed to project an overall superiority of off-
pump vs. on-pump surgery, nevertheless, small randomized control trials and large
meta-analysis studies have concluded that the incidence of a stroke is less than 1
% when anaortic off-pump techniques are advocated in patients with diseased
ascending aorta. Furthermore, off-pump techniques or their combination with hybrid
procedures may lead to a reduction of adverse outcome in the aged high-risk
population with concomitant poor left ventricular function and co-morbidities.
However, despite this, controversy still exists among the cardiac surgery community
in terms of the benefit of this technique and its safety; hence, off-pump is
becoming out of fashion. In this review paper, by looking at a "marginal group of
patients" (elderly, high risks, atherosclerotic aortas) we attempt to re-establish
and justify this technique and re-invent its usage.
AD - Cardiothoracic Department, Royal Victoria Hospital, Grosvenor Road, Belfast,
BT12 6BA, Northern Ireland, UK, hparissis@yahoo.co.uk.
AN - 25208659
AU - Parissis, H.
AU - Ramesh, B. C.
AU - Al-Alao, B.
DA - Nov
DO - 10.1007/s11748-014-0470-2
DP - NLM
ET - 2014/09/12
IS - 11
J2 - General thoracic and cardiovascular surgery
KW - Age Factors
Aorta/surgery
Cardiopulmonary Bypass/adverse effects
Comorbidity
Coronary Artery Bypass, Off-Pump/*adverse effects/methods
Humans
Risk Factors
Sex Factors
Stroke/etiology
LA - eng
N1 - 1863-6713
Parissis, Haralabos
Ramesh, B C
Al-Alao, Bassel
Journal Article
Review
Japan
Gen Thorac Cardiovasc Surg. 2014 Nov;62(11):660-70. doi: 10.1007/s11748-014-0470-2.
Epub 2014 Sep 11.
PY - 2014
SN - 1863-6705
SP - 660-70
ST - Off-pump coronary surgery: current justifications
T2 - Gen Thorac Cardiovasc Surg
TI - Off-pump coronary surgery: current justifications
VL - 62
ID - 2529
ER -
TY - JOUR
AB - Atrial fibrillation (AF) is the most common arrhythmia worldwide and a potent
independent risk factor for stroke. This study aimed to determine the prevalence of
AF in a population-based sample of adults in a rural region of Korea. Between
January 2005 and December 2009, 4,067 individuals (60.2 ± 11.2 yr old, M: F =
1,582:2,485) over 21 who were residents of the county of Yangpyeong, Korea,
participated in the study. AF was assessed on a resting 12-lead electrocardiogram
(ECG) in 4,053 of the participants. Blood tests and transthoracic echocardiography
(TTE) were also performed to investigate the relationship between left ventricular
mass and AF in the study group. Fifty-four cases (32 men) were diagnosed as AF
among the 4,053 subjects. The crude prevalence of AF was 1.3%. It was highest
(2.3%) among sixty- and seventy- year olds, and higher in men than women in all age
groups over 50. The prevalence in men was 2.0%, and in women 0.9%. In univariate
analysis, age, male gender, body mass index, total serum cholesterol, alanine
transaminase, serum creatinine, adiponectin level, and ischemic heart disease were
associated with AF. Among the TTE parameters, systolic and diastolic left
ventricular systolic internal dimension (LVID), and LV ejection fraction were
associated with AF. In this relatively healthy population in a rural area of Korea,
the prevalence of AF is 1.3%, and increases with age. Of the TTE parameters,
systolic and diastolic LVID and left atrial diameter are related to prevalence of
AF.
AD - Department of Cardiology, Hanyang University Guri Hospital, Guri city, Korea.
Department of Cardiology, Hanyang University Seoul Hospital, Seoul, Korea.
Department of Preventive Medicine, College of Medicine, Hanyang University, Seoul,
Korea.
AN - 26240485
AU - Park, H. C.
AU - Park, J. K.
AU - Choi, S. I.
AU - Kim, S. G.
AU - Kim, M. K.
AU - Choi, B. Y.
AU - Shin, J.
C2 - PMC4520938
DA - Aug
DO - 10.3346/jkms.2015.30.8.1078
DP - NLM
ET - 2015/08/05
IS - 8
J2 - Journal of Korean medical science
KW - Adult
Age Distribution
Aged
Aged, 80 and over
Asymptomatic Diseases/*epidemiology
Atrial Fibrillation/*diagnostic imaging/*epidemiology
Causality
Comorbidity
Echocardiography/*statistics & numerical data
Female
Humans
Male
Middle Aged
Prevalence
Risk Factors
Rural Population/*statistics & numerical data
Sex Distribution
Stroke Volume
Atrial Fibrillation
Community-based Cohort
Echocardiography
Electrocardiography
LA - eng
N1 - 1598-6357
Park, Hwan-Cheol
Park, Jin-Kyu
Choi, Sung Il
Kim, Soon-Gil
Kim, Mi Kyung
Choi, Bo Youl
Shin, Jinho
Journal Article
J Korean Med Sci. 2015 Aug;30(8):1078-84. doi: 10.3346/jkms.2015.30.8.1078. Epub
2015 Jul 15.
PY - 2015
SN - 1011-8934 (Print)
1011-8934
SP - 1078-84
ST - Prevalence of Atrial Fibrillation and Relation to Echocardiographic
Parameters in a Healthy Asymptomatic Rural Korean Population
T2 - J Korean Med Sci
TI - Prevalence of Atrial Fibrillation and Relation to Echocardiographic
Parameters in a Healthy Asymptomatic Rural Korean Population
VL - 30
ID - 2581
ER -
TY - JOUR
AB - BACKGROUND: The purpose of this study was to determine if patients with
atrial fibrillation (AF) and heart failure (HF) have a better prognosis when
systolic function is preserved as compared with those with depressed systolic
function. METHODS: Data from consecutive patients presenting to the emergency
department at Brigham and Women's Hospital from January 1997 to December 2002 who
had a diagnosis of AF and HF and a measure of ejection fraction (EF) were reviewed.
Vital status was determined from the Social Security Death Index. RESULTS: Of 478
patients (mean age 74 +/- 13 years; 47% women), EF was preserved (> 50%) in 46%.
Those with preserved left ventricular (LV) function were older (76 vs 72 years, P <
.0020), included more women (62 vs 35%, P < .0001), more likely to have a history
of hypertension and pulmonary disease and less likely to have had a prior
myocardial infarction. At 5 years, mortality was similar between the preserved and
depressed EF groups (50% vs 48%, P = .74). In multivariable analysis, age > 75
years, history of cancer, cerebrovascular disease, aortic valve disease, serum
creatinine > 2.0 mg/dL, and serum sodium < 130 mmol/L were associated with
increased mortality. Therapy with beta-blockers and angiotensin-converting enzyme
inhibitors/angiotensin receptor blocker were associated with lower mortality.
CONCLUSION: Patients who present to the emergency department with AF, HF, and
preserved LVEF have a similarly high mortality as compared with those with
depressed LVEF. Further study is needed to assess the impact of therapies and
clarify the reasons for the poor prognosis.
AD - Division of Cardiology, Queen Elizabeth II Health Sciences Centre, Halifax,
Nova Scotia, Canada. ratica.parkash@cdha.nshealth.ca
AN - 16209969
AU - Parkash, R.
AU - Maisel, W. H.
AU - Toca, F. M.
AU - Stevenson, W. G.
DA - Oct
DO - 10.1016/j.ahj.2004.12.014
DP - NLM
ET - 2005/10/08
IS - 4
KW - Aged
Atrial Fibrillation/*complications/*mortality/physiopathology
Female
Heart Failure/*complications/*mortality/physiopathology
Humans
Male
Prognosis
Risk Factors
LA - eng
N1 - 1097-6744
Parkash, Ratika
Maisel, William H
Toca, F Michael
Stevenson, William G
Comparative Study
Journal Article
United States
Am Heart J. 2005 Oct;150(4):701-6. doi: 10.1016/j.ahj.2004.12.014.
PY - 2005
SN - 0002-8703
SP - 701-6
ST - Atrial fibrillation in heart failure: high mortality risk even if ventricular
function is preserved
T2 - Am Heart J
TI - Atrial fibrillation in heart failure: high mortality risk even if ventricular
function is preserved
VL - 150
ID - 2905
ER -
TY - JOUR
AB - Sudden cardiac death is the leading mode of death in adults in the United
States. While it appears intimately associated with coronary artery disease, the
factors that render some subjects vulnerable to sudden cardiac death, while others
with the same coronary disease do not die suddenly, are unknown. An approach is
described which considers that sudden cardiac death represents a separate syndrome
of coronary artery disease within certain vulnerable subjects. It is suggested that
the response to psychosocial stress in vulnerable subjects results in deleterious
cerebral cortical influences on the autonomic control of the heart which render it
more vulnerable to ischemia-induced ventricular fibrillation. Studies in the pig,
an animal known to be susceptible to sudden death resulting from an environmental
stress, demonstrate that cerebral cortical influences on autonomic centers play a
central role in vulnerability to ventricular fibrillation after coronary artery
occlusion. In this model, the incidence of ventricular fibrillation can be reduced
by psychologic adaptation of the animal to his environment, cryoblockade of frontal
cortical brain stem pathways and by central administration of propranolol. The
relative role of adrenergic and cholinergic innervation of the heart is an
important consideration.
AD - Department of Medicine, Baylor College of Medicine, Houston, Texas 77030.
AN - 3425559
AU - Parker, G. W.
AU - Michael, L. H.
AU - Entman, M. L.
DA - Dec 28
DO - 10.1016/0002-9149(87)90677-1
DP - NLM
ET - 1987/12/28
IS - 18
KW - Animals
Coronary Disease/*etiology/mortality
Environment
Frontal Lobe/physiology
Hemodynamics
Humans
*Models, Biological
Propranolol/therapeutic use
Stress, Psychological/*complications
Swine
Ventricular Fibrillation/complications/drug therapy/physiopathology
LA - eng
N1 - Parker, G W
Michael, L H
Entman, M L
Journal Article
United States
Am J Cardiol. 1987 Dec 28;60(18):9J-14J. doi: 10.1016/0002-9149(87)90677-1.
PY - 1987
SN - 0002-9149 (Print)
0002-9149
SP - 9j-14j
ST - An animal model to examine the response to environmental stress as a factor
in sudden cardiac death
T2 - Am J Cardiol
TI - An animal model to examine the response to environmental stress as a factor
in sudden cardiac death
VL - 60
ID - 2812
ER -
TY - JOUR
AB - Mineralocorticoid receptor (MR) antagonism is a well-established treatment
modality for patients with hypertension, heart failure, and left ventricular
systolic dysfunction (LVSD) post-myocardial infarction (MI). There are emerging
data showing potential benefits of MR antagonists in other cardiovascular
conditions. Studies have shown association between MR activation and the
development of myocardial fibrosis, coronary artery disease, metabolic syndrome,
and cerebrovascular diseases. This review examines the preclinical and clinical
data of MR antagonists for novel indications including heart failure with preserved
ejection fraction (HFPEF), pulmonary arterial hypertension (PAH), arrhythmia,
sudden cardiac death, valvular heart disease, metabolic syndrome, renal disease,
and stroke. MR antagonists are not licensed for these conditions yet; however,
emerging data suggest that indication for MR antagonists are likely to broaden;
further studies are warranted.
AD - Sheffield Teaching Hospitals, National Health Service (NHS) Trust, Sheffield,
UK.
Manchester Heart Centre, Manchester Royal Infirmary, Manchester, UK. Electronic
address: javaid@doctors.net.uk.
Cardiovascular Centre, University of Michigan, Ann Arbor, MI 48109, USA.
Department of Cardiology and National Institute for Health Research (NIHR)
Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK.
INSERM, Centre d'Investigation Clinique and Centre Hospitalier Universitaire and
the Department of Cardiology, Nancy University, Université de Lorraine, Nancy,
France.
AN - 25707577
AU - Parviz, Y.
AU - Iqbal, J.
AU - Pitt, B.
AU - Adlam, D.
AU - Al-Mohammad, A.
AU - Zannad, F.
DA - Apr
DO - 10.1016/j.tem.2015.01.007
DP - NLM
ET - 2015/02/25
IS - 4
J2 - Trends in endocrinology and metabolism: TEM
KW - Animals
Arrhythmias, Cardiac/etiology/prevention & control
Cardiovascular Diseases/*drug therapy/metabolism/physiopathology
Death, Sudden, Cardiac/etiology/*prevention & control
Disease Progression
Humans
Hypertension, Pulmonary/etiology/prevention & control
Mineralocorticoid Receptor Antagonists/*therapeutic use
*Models, Biological
Off-Label Use
Receptors, Mineralocorticoid/*agonists/chemistry/metabolism
eplerenone
mineralocorticoid receptor
novel indications
spironolactone
LA - eng
N1 - 1879-3061
Parviz, Yasir
Iqbal, Javaid
Pitt, Bertram
Adlam, David
Al-Mohammad, Abdallah
Zannad, Faiez
PG/13/74/30264/British Heart Foundation/United Kingdom
Journal Article
Review
United States
Trends Endocrinol Metab. 2015 Apr;26(4):201-11. doi: 10.1016/j.tem.2015.01.007.
Epub 2015 Feb 20.
PY - 2015
SN - 1043-2760
SP - 201-11
ST - Emerging cardiovascular indications of mineralocorticoid receptor antagonists
T2 - Trends Endocrinol Metab
TI - Emerging cardiovascular indications of mineralocorticoid receptor antagonists
VL - 26
ID - 2839
ER -
TY - JOUR
AB - Eisenmenger syndrome is the most common consequence of congenital cyanotic
heart disease seen in adults; survival to the fifth decade of life is rare. Death
is very difficult to predict: it is related to sudden cardiac ventricular
arrhythmia, massive hemoptysis and right heart failure. In this paper, a patient
with ventricular septal defect and Eisenmenger reaction is described. The patient
was relatively well until 48 years of age, when she underwent surgery because of a
cerebral abscess without cerebral complications but with some deterioration of her
cardiac function. After discharge, the patient was readmitted to the hospital
because the electrocardiogram showed persistent ST inferior elevation.
Echocardiography demonstrated poor contractility and inferior akinesia. Sudden
ventricular tachycardia occurred and the patient became unconscious. She was
successfully resuscitated and, following a period of ventilation, the hemodynamics
stabilized and she was discharged 17 days later. She remained well two years later.
AD - Anesthesia/Surgical Intensive Care Unit, De Gasperis Niguarda Ca' Granda
Hospital, Milan, Italy. simonetta.passarani@bresciaonline.it
AN - 15229766
AU - Passarani, S.
AU - Vignati, G.
AU - Einaudi, A.
DA - Jun
DP - NLM
ET - 2004/07/02
IS - 8
KW - Cardiopulmonary Resuscitation
Eisenmenger Complex/diagnostic imaging/*etiology/mortality
Electrocardiography
Female
Heart Septal Defects, Ventricular/*complications/diagnostic imaging/therapy
Humans
Middle Aged
Myocardial Infarction/*complications/diagnostic imaging/therapy
Survival Rate
Tachycardia, Ventricular/diagnostic imaging/*etiology/therapy
Treatment Outcome
LA - eng
N1 - Passarani, Simonetta
Vignati, Gabriele
Einaudi, Arturo
Case Reports
Journal Article
England
Can J Cardiol. 2004 Jun;20(8):822-4.
PY - 2004
SN - 0828-282X (Print)
0828-282x
SP - 822-4
ST - Eisenmenger syndrome: a case of survival after ventricular tachycardia due to
inferior myocardial infarction in a 48-year-old patient with congenital large
ventricular septal defect
T2 - Can J Cardiol
TI - Eisenmenger syndrome: a case of survival after ventricular tachycardia due to
inferior myocardial infarction in a 48-year-old patient with congenital large
ventricular septal defect
VL - 20
ID - 2808
ER -
TY - JOUR
AB - OBJECTIVE: Evaluate the effect of administering intravenous protamine
immediately post-radiofrequency catheter ablation (RFCA) on thrombotic and bleeding
complications in heparinized patients. METHODS: Heparinized patients that had RFCA
for atrial or ventricular arrhythmias at our institution between January 2001 and
March 2006 and had a complete data set were included in this cohort evaluation.
Patients receiving at least one dose of protamine within 15 min of RFCA were deemed
the prophylactic group while those not receiving protamine within 15 min were the
control group. Thrombotic (cerebrovascular event, transient ischemic attack,
pulmonary embolism, deep vein thrombosis, or myocardial infarction) and bleeding
events (blood loss requiring transfusion, hematoma requiring intervention, or
intracranial hemorrhage) were compared between groups. RESULTS: Overall, 158
patients (74% male, 55 +/- 13.5) met inclusion criteria. Of these, 73.4% received
prophylactic protamine (average dose = 39 mg +/- 17). Only one patient (0.9%) in
the prophylactic protamine group and zero patients in the control group experienced
a thrombotic event (p > 0.99). Only two patients (1.7%) in the protamine group (n =
2 blood transfusions) and zero patients in the control group experienced bleeding
events (p = 0.839). CONCLUSIONS: Administering prophylactic intravenous protamine
to allow for quicker catheter removal following RFCA in heparinized patients did
not markedly impact thrombotic or bleeding complication rates in our population.
The perceived benefit in our institution to protamine administration in this
population is a reduction in postoperative patient immobilization and discomfort,
reduced PACU nursing care, and earlier time to discharge. Given the low rate of
thrombotic and bleeding events, a study of several thousand patients would be
needed to fully evaluate the impact on these events.
AD - Division of Cardiology, Hartford Hospital, Hartford, CT 06102, USA.
AN - 17318446
AU - Patel, A. A.
AU - Clyne, C. A.
AU - Henyan, N. N.
AU - White, C. M.
AU - Zembrowski, B. F.
AU - Migeed, M.
AU - Yarlagadda, R.
AU - Kluger, J.
AU - Coleman, C. I.
DA - Mar
DO - 10.1007/s10840-006-9063-z
DP - NLM
ET - 2007/02/24
IS - 2
Atrial Fibrillation/*therapy
Blood Loss, Surgical/prevention & control
*Catheter Ablation
Female
Heparin/therapeutic use
Heparin Antagonists/*therapeutic use
Humans
Male
Middle Aged
Protamines/*therapeutic use
Tachycardia, Ventricular/*therapy
Whole Blood Coagulation Time
LA - eng
N1 - Patel, Aarti A
Clyne, Christopher A
Henyan, Nickole N
White, C Michael
Zembrowski, Bryan F
Migeed, Magdy
Yarlagadda, Ravi
Kluger, Jeffrey
Coleman, Craig I
Journal Article
Netherlands
J Interv Card Electrophysiol. 2007 Mar;18(2):155-8. doi: 10.1007/s10840-006-9063-z.
Epub 2007 Feb 23.
PY - 2007
SN - 1383-875X (Print)
1383-875x
SP - 155-8
ST - The use of protamine after radiofrequency catheter ablation: a pilot study
TI - The use of protamine after radiofrequency catheter ablation: a pilot study
VL - 18
ID - 2948
ER -
TY - JOUR
AB - Atrial fibrillation (AF) is the most common cardiac arrhythmia encountered in
clinical practice. Although once considered a nuisance arrhythmia, recent clinical
trial evidence suggests that the presence of AF is an important independent
predictor of mortality and morbidity. The primary goals of AF treatment are relief
of symptoms and prevention of stroke. The value of anticoagulation with warfarin
has been proven unequivocally. Control of ventricular rate with atrioventricular
nodal blocking agents-the so-called rate control strategy-is least cumbersome and
sometimes the best approach. By contrast, efforts to restore and maintain sinus
rhythm using antiarrhythmic drugs-the rhythm control approach-although tedious, may
be ideal in patients who are young or highly symptomatic and in those with new-
onset AF. The relative merits of both treatment strategies are discussed in this
article, emphasizing the excellent clinical trial data that support each.
AN - 21392636
AU - Patel, C.
AU - Salahuddin, M.
AU - Jones, A.
AU - Patel, A.
AU - Yan, G. X.
AU - Kowey, P. R.
DA - Mar
DO - 10.1016/j.cpcardiol.2011.01.001
DP - NLM
ET - 2011/03/12
IS - 3
J2 - Current problems in cardiology
Heart Conduction System/drug effects
Humans
Treatment Outcome
LA - eng
N1 - 1535-6280
Patel, Chinmay
Salahuddin, Mohammed
Jones, Andria
Patel, Aashay
Yan, Gan-Xin
Kowey, Peter R
Journal Article
Review
United States
Curr Probl Cardiol. 2011 Mar;36(3):87-120. doi: 10.1016/j.cpcardiol.2011.01.001.
PY - 2011
SN - 0146-2806
SP - 87-120
ST - Atrial fibrillation: pharmacological therapy
T2 - Curr Probl Cardiol
TI - Atrial fibrillation: pharmacological therapy
VL - 36
ID - 2376
ER -
TY - JOUR
AB - PURPOSE OF REVIEW: Patients with atrial fibrillation and heart failure
experience an increased morbidity and mortality from the hemodynamic consequences
of atrial fibrillation and an increased stroke risk. Consequently, there has been
increased attention to procedural alternatives to pharmacologic rhythm control and
anticoagulation for stroke prevention. This review aims to evaluate the evidence
for atrial fibrillation ablation and left atrial appendage closure in heart failure
patients. RECENT FINDINGS: Several randomized control trials and systematic reviews
demonstrate the safety and efficacy of atrial fibrillation ablation in patients
with heart failure and left ventricular systolic dysfunction. In multiple trials,
these patients have shown clinical benefit from atrial fibrillation ablation
including improved left ventricular systolic function, quality of life, and
clinical heart failure symptoms. The evidence of clinical benefit of atrial
fibrillation ablation in heart failure patients with preserved ejection fraction
remains limited. Only a handful of randomized controlled trials have been performed
evaluating left atrial appendage closure, and there is insufficient data regarding
the safety and efficacy of these procedures in heart failure patients. SUMMARY:
Atrial fibrillation ablation in heart failure patients remains well tolerated with
an overall efficacy comparable to atrial fibrillation ablation in patients without
heart failure. There is consistent evidence for the clinical benefit of atrial
fibrillation ablation in heart failure patients with left ventricular systolic
dysfunction and limited evidence for atrial fibrillation ablation in heart failure
patients with preserved ejection fraction. Currently, there is insufficient data
regarding the safety and efficacy of left atrial appendage closure devices in heart
failure patients.
AD - From the Department of Medicine, Columbia University Medical Center, New
York, New York, USA.
AN - 25807223
AU - Patel, M. R.
AU - Biviano, A. B.
C2 - PMC4472367
C6 - NIHMS678832
DA - May
DO - 10.1097/hco.0000000000000168
DP - NLM
ET - 2015/03/26
IS - 3
KW - Atrial Appendage/*surgery
Humans
Septal Occluder Device
Treatment Outcome
LA - eng
N1 - 1531-7080
Patel, Minesh R
Biviano, Angelo B
1K23HL105893/HL/NHLBI NIH HHS/United States
Journal Article
Review
Curr Opin Cardiol. 2015 May;30(3):259-66. doi: 10.1097/HCO.0000000000000168.
PY - 2015
SN - 0268-4705 (Print)
0268-4705
SP - 259-66
ST - Atrial fibrillation ablation and left appendage closure in heart failure
patients
TI - Atrial fibrillation ablation and left appendage closure in heart failure
patients
VL - 30
ID - 2368
ER -
TY - JOUR
AB - STUDY OBJECTIVE: Assessing stroke risk associated with nonvalvular atrial
fibrillation depends on the evaluation of patient characteristics and clinical
features. Clinicians must determine that the net clinical benefit from
anticoagulation therapy outweighs its risk, namely, bleeding. Risk assessment for
stroke is commonly performed by calculating a CHA(2)DS(2)-VASc (congestive heart
failure/left ventricular dysfunction, hypertension, ≥75 years, diabetes mellitus,
previous stroke or transient ischemic attack or thromboembolism, vascular disease,
aged 65 to 74 years, sex female) score. It is possible that CHA(2)DS(2)-VASc scores
also have a relationship with the incidence of major bleeding. We examined the
relationship between CHA(2)DS(2)-VASc scores and major bleeding in rivaroxaban
users with nonvalvular atrial fibrillation. METHODS: Electronic medical records of
more than 10 million patients from the Department of Defense Military Health System
were queried to identify patients with nonvalvular atrial fibrillation who received
rivaroxaban from January 1, 2013, to June 30, 2015. Baseline characteristics of the
study population were described by CHA(2)DS(2)-VASc scores and major bleeding
status; major bleeding incidence was evaluated by CHA(2)DS(2)-VASc score category
and for each CHA(2)DS(2)-VASc component. RESULTS: Overall, 44,793 patients met the
inclusion criteria for this analysis. The major bleeding incidence rate was 2.84
(95% confidence interval 2.69 to 3.00) per 100 person-years. The incidence of major
bleeding increased from 0.30 to 5.40 per 100 person-years among patients with a
CHA(2)DS(2)-VASc score of 0 to 5 or higher, respectively. Fatal outcomes among
patients with major bleeding were positively correlated with CHA(2)DS(2)-VASc
scores; patients with higher scores had higher mortality rates. The CHA(2)DS(2)-
VASc component with the highest major bleeding incidence was for vascular disease,
5.69 (95% confidence interval 5.18 to 6.24) per 100 person-years. CONCLUSION:
Higher CHA(2)DS(2)-VASc scores are associated with increased incidence of major
bleeding in nonvalvular atrial fibrillation patients receiving rivaroxaban.
AD - Department of Emergency Medicine, Baylor College of Medicine, Houston, TX.
Electronic address: frankpeacock@gmail.com.
Department of Cardiology, Marine Corps, United States Navy, Naval Medical Center,
Portsmouth, VA.
Duke University Health System and Duke Clinical Research Institute, Durham, NC.
Clinical Epidemiology, Health ResearchTx, LLC, Trevose, PA.
Janssen Research and Development, LLC, Titusville, NJ.
AN - 27913059
AU - Peacock, W. F.
AU - Tamayo, S.
AU - Patel, M.
AU - Sicignano, N.
AU - Hopf, K. P.
AU - Yuan, Z.
DA - May
DO - 10.1016/j.annemergmed.2016.09.032
DP - NLM
ET - 2016/12/04
IS - 5
J2 - Annals of emergency medicine
KW - Aged
Factor Xa Inhibitors/adverse effects/*therapeutic use
Female
Hemorrhage/*chemically induced
Humans
Male
Middle Aged
Risk Assessment
Risk Factors
Rivaroxaban/adverse effects/*therapeutic use
LA - eng
N1 - 1097-6760
Peacock, W Frank
Tamayo, Sally
Patel, Manesh
Sicignano, Nicholas
Hopf, Kathleen P
Yuan, Zhong
Journal Article
United States
Ann Emerg Med. 2017 May;69(5):541-550.e1. doi: 10.1016/j.annemergmed.2016.09.032.
Epub 2016 Nov 29.
PY - 2017
SN - 0196-0644
SP - 541-550.e1
ST - CHA(2)DS(2)-VASc Scores and Major Bleeding in Patients With Nonvalvular
Atrial Fibrillation Who Are Receiving Rivaroxaban
T2 - Ann Emerg Med
TI - CHA(2)DS(2)-VASc Scores and Major Bleeding in Patients With Nonvalvular
Atrial Fibrillation Who Are Receiving Rivaroxaban
VL - 69
ID - 2564
ER -
TY - JOUR
AB - OBJECTIVES: Concomitant surgical ablation of atrial fibrillation (AF) is a
safe and feasible procedure. However, many surgeons are reluctant to perform it in
patients with heart failure. We investigated the safety and efficacy of AF ablation
in patients with a severely reduced left ventricular ejection fraction (LVEF <35%).
METHODS: Between July 2003 and August 2011, 59 patients with severely reduced LVEF
underwent concomitant surgical AF ablation, by either left atrial (LA) lesion set
or bilateral pulmonary vein isolation in patients with paroxysmal AF, and biatrial
lesion set in patients with persistent AF. Follow-up echocardiography (ECG) was
conducted after 12 months; rhythm monitoring was accomplished by either 24-h Holter
echocardiography or event recorder monitoring. RESULTS: The patients' mean age was
68 ± 9 years (male patients, 71%). Paroxysmal AF was present in 24 (41%) and
persistent AF in 35 (59%) patients. No ablation-related adverse events occurred.
The one-year survival rate was 95% without differences in patients with and without
restoration of sinus rhythm (SR). The overall rate of SR was 54% after 1 year,
showing a superior result in patients with preoperative paroxysmal AF compared with
those with preoperative persistent AF (70 vs 41%, P < 0.001). LVEF improved from 29
± 8% preoperatively to 39 ± 7% after 12 months of follow-up. The improvement in
LVEF was significantly higher in patients with restored SR than in those with AF
(16 vs 5%; P < 0.001). Only patients with restoration of SR showed a statistically
significant reduction in New York Heart Association functional class at the 12-
month follow-up (P = 0.0013). CONCLUSIONS: Surgical AF ablation was safe and
feasible in patients with severely reduced LVEF. The restoration of SR led to a
significantly higher improvement in LVEF and alleviation of clinical heart failure
symptoms, not observed if AF persisted postoperatively.
AD - Department of Cardiovascular Surgery, University Heart Center Hamburg,
Hamburg, Germany s.pecha@uke.de.
Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg,
Germany.
Department of Cardiology and Electrophysiology, University Heart Center Hamburg,
Hamburg, Germany.
AN - 24446474
AU - Pecha, S.
AU - Ahmadzade, T.
AU - Schäfer, T.
AU - Subbotina, I.
AU - Steven, D.
AU - Willems, S.
AU - Reichenspurner, H.
AU - Wagner, F. M.
DA - Jul
DO - 10.1093/ejcts/ezt602
DP - NLM
ET - 2014/01/22
IS - 1
KW - *Ablation Techniques
Aged
Atrial Fibrillation/*complications/mortality/*surgery
Echocardiography
Feasibility Studies
Female
Follow-Up Studies
Heart Failure/classification/*complications/mortality
Hospital Mortality
Humans
Male
Stroke/epidemiology
*Stroke Volume
Atrial fibrillation
Heart failure
Surgical ablation
LA - eng
N1 - 1873-734x
Pecha, Simon
Ahmadzade, Teymour
Schäfer, Timm
Subbotina, Irina
Steven, Daniel
Willems, Stephan
Reichenspurner, Hermann
Wagner, Florian Mathias
Journal Article
Germany
Eur J Cardiothorac Surg. 2014 Jul;46(1):67-71. doi: 10.1093/ejcts/ezt602. Epub 2014
Jan 19.
PY - 2014
SN - 1010-7940
SP - 67-71
ST - Safety and feasibility of concomitant surgical ablation of atrial
fibrillation in patients with severely reduced left ventricular ejection fraction
TI - Safety and feasibility of concomitant surgical ablation of atrial
fibrillation in patients with severely reduced left ventricular ejection fraction
VL - 46
ID - 2661
ER -
TY - JOUR
AB - A 55-year-old man was found unconscious with ventricular fibrillations at his
working place near a power press. CPR was successful. After three weeks of
intensive care the patient died of ischemic brain damage. The first suspected
diagnosis of myocardial infarction was revised when typical current marks were
detected on both palms. At the working place the top of a lubricating grease
container was found to be energized due to a technical damage: There is a round,
multiple-pole plug mounted upon the container top the proper orientation of which
is coded by a set of five plastic nipples. All the nipples had been abraded by
longlasting mechanical stress, so that the plug could be connected in a variety of
possible orientations. In actual fact, the incorrect orientation caused a voltage
of up to 240 V to the container top.
AD - Institut für Rechtsmedizin, Universität Heidelberg.
AN - 1482231
AU - Pedal, I.
AU - Graf, W.
DA - Nov-Dec
DP - NLM
ET - 1992/11/01
IS - 5-6
J2 - Archiv fur Kriminologie
KW - Accidents, Occupational/*legislation & jurisprudence
Critical Care
Electric Conductivity
Electric Injuries/*pathology
Equipment Failure
Humans
Male
Middle Aged
Muscles/pathology
Necrosis
Ventricular Fibrillation/pathology
LA - ger
N1 - Pedal, I
Graf, W
Case Reports
English Abstract
Journal Article
Germany
Arch Kriminol. 1992 Nov-Dec;190(5-6):156-62.
OP - Stromunfall mit dreiwöchiger Uberlebenszeit.
PY - 1992
SN - 0003-9225 (Print)
0003-9225
SP - 156-62
ST - [Electrocution accident with three-week survival]
T2 - Arch Kriminol
TI - [Electrocution accident with three-week survival]
VL - 190
ID - 2976
ER -
TY - JOUR
AB - Nicardipine, a new 1-4 dihydropyridine calcium antagonist, has chemical
properties that allow oral and stable intravenous preparations. It is the first
intravenous dihydropyridine calcium antagonist available in the United States.
Among its drug class it has a unique chemical structure that affords properties
useful in the treatment of acute cardiovascular conditions, such as myocardial
ischemia, congestive heart failure, hypertension, cerebrovascular disease, and
other related disorders. In patients with coronary artery disease, intravenous
nicardipine has been found to reduce myocardial oxygen demand by reducing afterload
and increasing myocardial oxygen supply through coronary vasodilatation. It
enhances left ventricular performance and augments coronary blood flow beyond that
required by increased myocardial oxygen consumption. Nicardipine may also offer
protection from ischemic injury to the heart and central nervous system. Alone and
in combination with other antihypertensive agents, nicardipine has been shown to be
effective in the treatment of mild to moderate hypertension. It is safe for use in
patients with certain types of conduction disturbances because it does not greatly
affect sinoatrial and atrioventricular conduction. Additional advantages for
nicardipine's use in the management of acute cardiovascular disorders are its rapid
onset and short duration of action.
AD - Department of Medicine, University of Florida, Gainesville.
AN - 2248426
AU - Pepine, C. J.
AU - Lambert, C. R.
DA - Nov
DP - NLM
ET - 1990/11/01
IS - 11 Pt 2
J2 - Angiology
KW - Animals
Arrhythmias, Cardiac/drug therapy
Cardiovascular System/*drug effects
Coronary Disease/drug therapy
Heart/drug effects
Hemodynamics/drug effects
Humans
Nicardipine/administration & dosage/chemistry/pharmacokinetics/*pharmacology
LA - eng
N1 - Pepine, C J
Lambert, C R
Journal Article
Review
United States
Angiology. 1990 Nov;41(11 Pt 2):978-86.
PY - 1990
SN - 0003-3197 (Print)
0003-3197
SP - 978-86
ST - Cardiovascular effects of nicardipine
T2 - Angiology
TI - Cardiovascular effects of nicardipine
VL - 41
ID - 2980
ER -
TY - JOUR
AB - Chronic atrial fibrillation (CAF) may be complicated by asymptomatic small
silent cerebral infarctions as well as by stroke. The echocardiographic findings in
29 patients with CAF and 29 controls in sinus rhythm are presented. The cerebral
computed tomography (CT) findings in these patients were previously published and
significantly more small low-density lesions, probably reflecting previous
infarctions, were found in patients with CAF than in controls. The aim of the
present study was to evaluate if patients with such cerebral lesions had
characteristic echocardiographic abnormalities with special reference to patients
with CAF. No significant differences could be detected between the groups with and
without cerebral lesions regarding the occurrence of valvular heart disease, left
ventricular dysfunction, end-diastolic diameter of the left ventricle, left atrial
dimension and left ventricular fractional shortening. Only seven patients with CAF
(24%) compared with 21 in sinus rhythm (72%) had normal echocardiograms (P less
than 0.001). In conclusion, echocardiography gave no guidance to why some patients
developed cerebral low-density areas on CT.
AD - Department of Neurology, University Hospital, Copenhagen, Denmark.
AN - 2606118
AU - Petersen, P.
AU - Pedersen, F.
AU - Madsen, E. B.
AU - Brun, B.
AU - Gyldensted, C.
AU - Boysen, G.
DA - Dec
DO - 10.1093/oxfordjournals.eurheartj.a059432
DP - NLM
ET - 1989/12/01
IS - 12
KW - Aged
Aged, 80 and over
Atrial Fibrillation/complications/*diagnosis
Cerebrovascular Disorders/*diagnostic imaging/etiology
Chronic Disease
*Echocardiography
Female
Humans
Male
Middle Aged
LA - eng
N1 - Petersen, P
Pedersen, F
Madsen, E B
Brun, B
Gyldensted, C
Boysen, G
Journal Article
England
Eur Heart J. 1989 Dec;10(12):1101-4. doi: 10.1093/oxfordjournals.eurheartj.a059432.
PY - 1989
SN - 0195-668X (Print)
0195-668x
SP - 1101-4
ST - Echocardiography and cerebral computed tomography in chronic atrial
fibrillation
T2 - Eur Heart J
TI - Echocardiography and cerebral computed tomography in chronic atrial
fibrillation
VL - 10
ID - 2822
ER -
TY - JOUR
AB - BACKGROUND: ICD shocks occurring in conscious patients (as in the case of
well-tolerated arrhythmias, electromagnetic interference, or oversensing) have a
deleterious impact on the quality of life. We evaluated if a hemodynamic parameter,
calculated from the right ventricular pressure (RVP) or systemic arterial pressure
(AP) signals, could predict early clinical symptoms of cerebral hypoperfusion
during induced ventricular tachycardias (VTs). METHODS AND RESULTS: We analyzed 42
tolerated (no symptoms) and 30 untolerated (syncope or severe symptoms within 30
seconds from the onset) VTs, induced during electrophysiological study. The cycle
length (CL) and the hemodynamic data (mean AP and RVP, arterial pulse pressure and
RV pulse pressure, and maximum AP and RVP dP/dT) were automatically sampled in two
VT epochs: the "detection" window, from beat 24 to 32, and the "preintervention"
window, immediately before the first therapeutic attempt. Although the CL and all
the hemodynamic parameters (expressed as % change versus pre-VT values) were
significantly lower in untolerated versus tolerated VTs both at detection and
preintervention (with the exception of the mean RVP which progressively increased
in both groups), ROC analysis demonstrated that only the preintervention RV pulse
pressure showed no overlap between groups, providing 100% sensitivity and positive
predictive value. CONCLUSIONS: The reduction of the RV pulse pressure is a better
predictor of early cerebral symptoms than CL or other hemodynamic indexes during
induced VTs. Since long-term RVP monitoring is feasible, this parameter could be
incorporated into ICDs decisional path, in the perspective of reducing unnecessary,
painful shocks.
AD - Laboratorio di Elettrofisiologia, Azienda Ospedaliera di Busto Arsizio,
Varese, Italy. epetrucci@aobusto.it
AN - 18803561
AU - Petrucci, E.
AU - Sarzi Braga, S.
AU - Balian, V.
AU - Pedretti, R. F.
DA - Mar
DO - 10.1111/j.1540-8167.2008.01306.x
DP - NLM
ET - 2008/09/23
IS - 3
KW - Aged
Blood Pressure
Cerebral Infarction/*complications/*diagnosis
Electrophysiologic Techniques, Cardiac/*adverse effects
Female
Humans
Male
Middle Aged
Pain/diagnosis/*etiology/*prevention & control
Prognosis
Tachycardia, Ventricular/diagnosis/*prevention & control
LA - eng
N1 - 1540-8167
Petrucci, Ettore
Sarzi Braga, Simona
Balian, Vruyr
Pedretti, Roberto F E
Journal Article
United States
J Cardiovasc Electrophysiol. 2009 Mar;20(3):299-306. doi: 10.1111/j.1540-
8167.2008.01306.x. Epub 2008 Sep 17.
PY - 2009
SN - 1045-3873
SP - 299-306
ST - Right ventricular pressure changes during induced ventricular tachycardias
predict clinical symptoms of cerebral hypoperfusion: implications for a reduction
of unnecessary, painful ICD shocks
TI - Right ventricular pressure changes during induced ventricular tachycardias
predict clinical symptoms of cerebral hypoperfusion: implications for a reduction
of unnecessary, painful ICD shocks
VL - 20
ID - 2410
ER -
TY - JOUR
AB - BACKGROUND: B-type natriuretic peptides are excellent markers of cardiac
function and are strong prognostic parameters in patients with coronary heart
disease and heart failure. We examined the diagnostic and prognostic value of
natriuretic peptides in a heterogeneous group of patients of a cardiological
university hospital. METHODS: NT-pro-BNP was assessed in 573 inpatients (66 % male,
median age 66 years) and association with demographic and cardiological parameters,
in-hospital course as well as the combined endpoint of death, heart failure
hospitalization and stroke was analyzed during a median follow-up time of 1117
days. RESULTS: NT-pro-BNP was significantly associated with age, diastolic blood
pressure, renal function, previous myocardial infarction, arterial occlusive
disease, atrial fibrillation, NYHA class and left-ventricular dysfunction.
Differentiation of distinct cardiac diseases by NT-pro-BNP was not possible. NT-
pro-BNP identified patients with a length of hospital stay of more than 12 days
with a sensitivity of 88,2 % and a negative predictive value of 97 %. Supramedian
NT-pro-BNP values (> 300 pg/ml) indicated a relative risk for the combined endpoint
of 7,5 (95 % CI 4,1 - 13,8) compared to inframedian NT-pro-BNP values. Prognostic
value of NT-pro-BNP was independent of and stronger than demographic and
cardiological risk markers. CONCLUSION: NT-pro-BNP is a strong and independent
predictor of in-hospital course and long-term outcome in inpatients with
cardiovascular disease. NT-pro-BNP assessment allows a risk-adapted patient
management for non-cardiologists.
AD - Klinik III für Innere Medizin der Universität Köln, Kerpener Str. 62, 50937
Köln. roman.pfister@uk-koeln.de
AN - 18335382
AU - Pfister, R.
AU - Tan, D.
AU - Thekkanal, J.
AU - Erdmann, E.
AU - Schneider, C. A.
DA - Mar
DO - 10.1055/s-2008-1067282
DP - NLM
ET - 2008/03/13
IS - 12
KW - Aged
Arterial Occlusive Diseases/blood/diagnosis/physiopathology
Atrial Fibrillation/blood/diagnosis/physiopathology
Biomarkers/blood
Blood Pressure
Cardiovascular Diseases/*blood/diagnosis/physiopathology
Female
Humans
Male
Middle Aged
Prognosis
Stroke/blood/diagnosis/physiopathology
Ventricular Dysfunction, Left/*blood/diagnosis/physiopathology
LA - ger
N1 - 1439-4413
Pfister, R
Tan, D
Thekkanal, J
Erdmann, E
Schneider, C A
English Abstract
Journal Article
Germany
Dtsch Med Wochenschr. 2008 Mar;133(12):564-9. doi: 10.1055/s-2008-1067282.
OP - Welchen Aussagewert hat der kardiale Funktionsmarker NT-pro-BNP für den
Nicht-Kardiologen? Eine Untersuchung an 573 hospitalisierten Patienten mit
kardiovaskulärer Erkrankung.
PY - 2008
SN - 0012-0472
SP - 564-9
ST - [Predictive value of NT-pro-BNP for the non-cardiologist. A study on 573
hospitalized patients with cardiovascular disease]
TI - [Predictive value of NT-pro-BNP for the non-cardiologist. A study on 573
hospitalized patients with cardiovascular disease]
VL - 133
ID - 2624
ER -
TY - JOUR
AB - BACKGROUND: In patient with non-valvular atrial fibrillation (AF), over 90%
of thrombus accumulation originates in the left atrial appendage (LAA). Warfarin
significantly reduces risk of stroke. However, long-term anticoagulant therapy is
associated with a significant risk of major bleeding, particularly in elderly.
Transcatheter occlusion of left atrial appendage with Watchman device has proved to
be non-inferior to warfarin in preventing stroke in non-valvular AF patients. No
previous report of transcatheter occlusion of LAA was found in Thailand OBJECTIVE:
To evaluate short-term results of left atrial appendage closure with the Watchman®
device in patient with non-valvular AF performed at King Chulalongkorn Memorial
Hospital (KCMH). MATERIAL AND METHOD: Between November 2012 and December 2014, 12
consecutives patients underwent percutaneous transcatheter left atrial appendage
closure. Data included patient's characteristics, embolic risk factors, bleeding
risk score, procedural finding, complications, in-hospital outcomes, and
antithrombotic management were retrospectively reviewed RESULTS: Percutaneous LAA
occlusion was successfully performed in all 12 patients. The mean age was 71.2 ±
8.1 years. The history of previous bleeding was seen in four patients (33%). All
patients had good left ventricular systolic function. The mean CHADS2 score was 3.2
± 1.3, the mean CHA2DS2-VASc score was 4.8 ± 1.6 and the mean HAS-BLED score was
2.5 ± 0.9. The average LAA orifice diameter was 21.7 ± 3.4 mm, and the median
implant size was 27.0 mm. The compression ratio was 15.2 ± 6.2%. Three patients
(25%) were performed under general anesthesia, nine patients (75%) were performed
with local anesthesia. The averageprocedure time was 61.2 ± 18.5 minutes. The
average fluoroscopy time was 6.8 ± 3.3 minutes. There was no device embolization or
pericardial effusion. There was no periprocedural cerebral event, assess site
bleeding, or death during hospital admission. Mild peridevice leak was observed in
three patients (25%), and all had disappeared on TEE performed at the 45-day
follow-up. The median length of stay was two days. CONCLUSION: The result of the
present study showed that percutaneous LAA occlusion with the Watchman device was
feasible and safe. The successfulness of the procedures and periprocedural
complications were similar to standard in literature.
AN - 26638585
AU - Pheerawong, P.
AU - Songmuang, S. B.
AU - Lertsuwunseri, V.
AU - Satitthummanid, S.
AU - Srimahachota, S.
DA - Oct
DP - NLM
ET - 2015/12/08
IS - 10
J2 - Journal of the Medical Association of Thailand = Chotmaihet thangphaet
KW - Aged
Anesthesia, General
Cardiac Catheterization/methods
Cardiac Surgical Procedures/*instrumentation/methods
Disease Management
Humans
Prosthesis Implantation/*methods
Thailand
Treatment Outcome
LA - eng
N1 - Pheerawong, Phattaraphong
Songmuang, Smonporn Boonyaratavej
Lertsuwunseri, Vorarit
Satitthummanid, Sudarat
Srimahachota, Suphot
Journal Article
Thailand
J Med Assoc Thai. 2015 Oct;98(10):942-9.
PY - 2015
SN - 0125-2208 (Print)
0125-2208
SP - 942-9
ST - Clinical Results of Left Atrial Appendage Closure with Watchman Device in
T2 - J Med Assoc Thai
TI - Clinical Results of Left Atrial Appendage Closure with Watchman Device in
VL - 98
ID - 3034
ER -
TY - JOUR
AB - Many patients with atrial fibrillation have substantial symptoms despite
ventricular rate control and require restoration of sinus rhythm to improve their
quality of life. Acute restoration (ie, cardioversion) and maintenance of sinus
rhythm in patients with atrial fibrillation are referred to as rhythm control. The
decision to pursue rhythm control is based on symptoms, the type of atrial
fibrillation (paroxysmal, persistent, or long-standing persistent), patient
comorbidities, general health status, and anticoagulation status. Many patients
have recurrent atrial fibrillation and require further intervention to maintain
long term sinus rhythm. Antiarrhythmic drug therapy is generally recommended as a
first-line therapy and drug selection is on the basis of the presence or absence of
structural heart disease or heart failure, electrocardiographical variables, renal
function, and other comorbidities. In patients who continue to have recurrent
atrial fibrillation despite medical therapy, catheter ablation has been shown to
substantially reduce recurrent atrial fibrillation, decrease symptoms, and improve
quality of life, although recurrence is common despite continued advancement in
ablation techniques.
AD - Duke Center for Atrial Fibrillation, Clinical Cardiac Electrophysiology, Duke
University Medical Center, Durham, NC, USA. Electronic address:
jonathan.piccini@duke.edu.
Centre Hospitalier Universitaire Trousseau, Tours, France.
AN - 27560278
AU - Piccini, J. P.
AU - Fauchier, L.
DA - Aug 20
DO - 10.1016/s0140-6736(16)31277-6
DP - NLM
ET - 2016/08/26
IS - 10046
Atrial Fibrillation/*drug therapy/physiopathology
*Catheter Ablation/adverse effects
*Electric Countershock/adverse effects/methods
Heart Failure/drug therapy/*prevention & control
Humans
Quality of Life
Time Factors
LA - eng
N1 - 1474-547x
Piccini, Jonathan P
Fauchier, Laurent
1U19 HS021092/HS/AHRQ HHS/United States
Journal Article
Review
England
Lancet. 2016 Aug 20;388(10046):829-40. doi: 10.1016/S0140-6736(16)31277-6.
PY - 2016
SN - 0140-6736
SP - 829-40
ST - Rhythm control in atrial fibrillation
T2 - Lancet
TI - Rhythm control in atrial fibrillation
VL - 388
ID - 2282
ER -
TY - JOUR
AB - BACKGROUND AND PURPOSE: Although sudden death (SD) accounts for numerous
cases of premature mortality in patients with cerebral autosomal dominant
arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the risk
factors responsible for this dramatic event remain unclear. We sought possible
differences in the QT variability index (QTVI) -- a well-known index of temporal
dispersion in myocardial repolarization strongly associated with the risk of SD --
between a group of patients with CADASIL and healthy controls. METHODS: A total of
13 patients with CADASIL and 13 healthy volunteers underwent a 5-min
electrocardiogram recording to calculate the QTVI. All the patients also underwent
a clinical assessment, including functional status by Rankin score, and a magnetic
resonance imaging (MRI) brain scan for quantitative analysis of T2-weighted (T2-W)
and T1-weighted (T1-W) lesion volume (LV). RESULTS: Short-term QT-interval analysis
showed significantly higher QTVI (P = 0.029) in patients than in controls. In
patients, notwithstanding the limitations of the small sample size, QTVI also well
correlated with T1-W LV (r = 0.747, P = 0.003) and T2-W LV (r = 0.731, P = 0.005).
CONCLUSION: Because patients with CADASIL have increased temporal cardiac
repolarization variability as assessed by QTVI, this mechanism could underlie these
patients' risk of SD. Whether this easily assessed, non-invasive marker could be
used to stratify the risk of malignant ventricular arrhythmias in patients with
CADASIL and, possibly, to guide their therapeutic management warrants confirmation
from larger prospective studies.
AD - Dipartimento di Scienze dell'Invecchiamento, Policlinico Umberto I,
Università La Sapienza, Rome, Italy. gianfranco.piccirillo@uniroma1.it
AN - 18803652
AU - Piccirillo, G.
AU - Magrì, D.
AU - Mitra, M.
AU - Rufa, A.
AU - Zicari, E.
AU - Stromillo, M. L.
AU - De Stefano, N.
AU - Dotti, M. T.
DA - Nov
DO - 10.1111/j.1468-1331.2008.02300.x
DP - NLM
ET - 2008/09/23
IS - 11
KW - Adult
Aged
Arrhythmias, Cardiac/diagnosis/*etiology/physiopathology
Brain/blood supply/pathology/physiopathology
CADASIL/*complications
Cerebral Arteries/pathology
Death, Sudden, Cardiac/*etiology
Electrocardiography
Female
Heart Ventricles/innervation/physiopathology
Humans
Male
Middle Aged
Pilot Projects
LA - eng
N1 - 1468-1331
Piccirillo, G
Magrì, D
Mitra, M
Rufa, A
Zicari, E
Stromillo, M L
De Stefano, N
Dotti, M T
Journal Article
England
Eur J Neurol. 2008 Nov;15(11):1216-21. doi: 10.1111/j.1468-1331.2008.02300.x. Epub
2008 Sep 18.
PY - 2008
SN - 1351-5101
SP - 1216-21
ST - Increased QT variability in cerebral autosomal dominant arteriopathy with
subcortical infarcts and leukoencephalopathy
T2 - Eur J Neurol
TI - Increased QT variability in cerebral autosomal dominant arteriopathy with
subcortical infarcts and leukoencephalopathy
VL - 15
ID - 2592
ER -
TY - JOUR
AB - The typical QRS patterns of myocardial infarction (MI-QRS) are commonly
attributed to myocardial cellular death. However, observation of a transient
appearance of MI-QRS during coronary insufficiency, the disappearance of MI-QRS
after coronary by-pass surgery and the appearance of MI-QRS after intracranial
hemorrhage suggest that a different electrophysiological mechanism may be at work.
There is a single convincing explanation for all these observations. It seems
possible, at least theoretically, that a localized conduction disturbance can
generate or contribute to the generation of the MI-QRS. The results obtained in
nine out of 194 cases studied by means of premature right atrial stimulation (PRAS)
in our laboratory seem to confirm this hypothesis. In five of them we observed
typical MI-QRS in the aberrant beats which were absent in the basal tracings. In
the other four cases, MI-QRS which were present in basal tracings disappeared in
the aberrant beats. In three of these a reduction in the duration of QRS was also
observed, while in the fourth the duration of QRS did not change. In no case could
the alterations of QRS (induction or disappearance of MI-QRS) be explained by a
classical conduction disturbance, preexcitation or by a premature ventricular beat.
While the induction of MI-QRS was clearly due to an aberrant conduction in the
supraventricular beats, the disappearance of basal MI-QRS changes in premature
supraventricular beats is more difficult to explain. One possible
electrophysiological mechanism could be a supernormal phase conduction. If this is
the case, the basal MI-QRS could be due to a ventricular conduction disturbance. In
conclusion, our results suggest that MI-QRS can be generated, at least in our
cases, by a localized conduction disturbance.
AN - 6644220
AU - Piccolo, E.
AU - Delise, P.
AU - Raviele, A.
AU - D'Este, D.
AU - Lucangeli, F.
AU - Pascotto, P.
AU - Dainese, F.
AU - Di Pede, F.
DA - Oct
DO - 10.1016/s0022-0736(83)80089-2
DP - NLM
ET - 1983/10/01
IS - 4
J2 - Journal of electrocardiology
KW - Adult
Aged
Atrioventricular Node/*physiopathology
Electrophysiology
Female
Humans
Male
Middle Aged
Myocardial Infarction/etiology/*physiopathology
Time Factors
Vectorcardiography
LA - eng
N1 - Piccolo, E
Delise, P
Raviele, A
D'Este, D
Lucangeli, F
Pascotto, P
Dainese, F
Di Pede, F
Journal Article
United States
J Electrocardiol. 1983 Oct;16(4):385-96. doi: 10.1016/s0022-0736(83)80089-2.
PY - 1983
SN - 0022-0736 (Print)
0022-0736
SP - 385-96
ST - Possible role of a ventricular conduction disturbance in the electrogenesis
of the ECG-VCG signs of myocardial infarction
T2 - J Electrocardiol
TI - Possible role of a ventricular conduction disturbance in the electrogenesis
of the ECG-VCG signs of myocardial infarction
VL - 16
ID - 2917
ER -
TY - JOUR
AB - BACKGROUND: the aim of the study was to analyze all-cause mortality and
predictors of long-term survival after myocardial revascularization for ischemic
cardiomyopathy. METHOD: data of 101 patients (mean age, 63.86 years; age range, 30-
85 years; 92% male), operated on with stable coronary artery disease and left
ventricular ejection fraction <30% between April 2000 and June 2010, were analyzed.
RESULTS: operative mortality was 1.9% (2/101). There was a significant improvement
in left ventricular ejection fraction from 25.99% ± 3.8% preoperatively to 34% ±
12% postoperatively (p <0.0001). The mean duration of follow-up was 56.3 ± 33
months, and it was 97% complete (98/101). There were 18/96 (18.75%) late deaths.
Overall actuarial survival at 1, 3, 5, and 10 years was 96%, 89%, 83% and 75%,
respectively. Univariate predictors of late death were preoperative arrhythmia,
cerebrovascular disease, peripheral vascular disease, and logistic EuroSCORE.
Multivariate predictors of late death were cerebrovascular disease and preoperative
arrhythmia. CONCLUSION: our study suggests that myocardial revascularization for
ischemic cardiomyopathy improves left ventricular ejection fraction and is
associated with favorable long-term survival. Patients with cerebrovascular disease
and preoperative arrhythmias had poorer outcomes.
AD - Department of Cardiothoracic Surgery, Princess Alexandra Hospital, Brisbane,
Australia.
AN - 23284108
AU - Pinto, N.
AU - Haluska, B.
AU - Mundy, J.
AU - Griffin, R.
AU - Wood, A.
AU - Shah, P.
DA - Dec
DO - 10.1177/0218492312442509
DP - NLM
ET - 2013/01/04
IS - 6
J2 - Asian cardiovascular & thoracic annals
KW - Adult
Aged
Aged, 80 and over
Female
Humans
Male
Middle Aged
Myocardial Ischemia/*mortality/physiopathology/*surgery
*Myocardial Revascularization
Prognosis
Stroke Volume
Survival Rate
Time Factors
LA - eng
N1 - 1816-5370
Pinto, Nigel
Haluska, Brian
Mundy, Julie
Griffin, Rayleene
Wood, Annabelle
Shah, Pallav
Journal Article
England
Asian Cardiovasc Thorac Ann. 2012 Dec;20(6):669-74. doi: 10.1177/0218492312442509.
PY - 2012
SN - 0218-4923
SP - 669-74
ST - Ischemic cardiomyopathy: midterm survival and its predictors
T2 - Asian Cardiovasc Thorac Ann
TI - Ischemic cardiomyopathy: midterm survival and its predictors
VL - 20
ID - 3089
ER -
TY - JOUR
AB - INTRODUCTION: Certain electrocardiographic (ECG) abnormalities are associated
with ischemic stroke (IS), especially cardioembolic subtype. Besides atrial
fibrillation, markers of left ventricular hypertrophy (LVH) or atrial pathology
also reflect elevated risk. We studied the association of ECG markers with IS in
young adults. METHODS: We performed a case-control study including 567 consecutive
IS patients aged 15-49 years (inclusion period: 1994-2007) and one or two age- and
sex-matched control subjects enrolled during 1978-1980 (n = 1033), and investigated
also the stroke aetiologic subgroups. We studied ECGs of all participants for
markers of atrial abnormality, i.e. P-terminal force (PTF) on lead V1, interatrial
blocks (IAB; P-wave duration ≥110 ms), and LVH. Conditional logistic regression
analyses were used. RESULTS: IAB (hazard ratio [HR]: 1.57, 95% confidence interval
[CI]: 1.16-2.13) and PTF combined with LVH (HR: 6.83, 95% CI: 1.65-28.31), were
independently associated with IS. LVH, abnormal P-wave (HR: 6.87, 95% CI: 1.97-
135.29), PTF, IAB, and combinations of these P-wave abnormalities with LVH - were
associated with cardioembolic subtype. Abnormal P-wave and IAB were associated with
cryptogenic stroke subtype. In unadjusted analysis, LVH was associated with small-
vessel disease subtype. CONCLUSION: P-wave abnormalities on ECG were associated
with cardioembolic but also with a cryptogenic subtype of IS. Key messages ECG
patterns associated with atrial pathology are markers of increased risk of ischemic
stroke in young adults. The ECG markers reflecting atrial pathology were seen in
patients with cardioembolic and cryptogenic subtypes of ischemic stroke.
AD - a Department of Cardiology , Heart and Lung Center, Helsinki University
Hospital, University of Helsinki , Helsinki , Finland.
b Department of Neurology, Clinical Neurosciences , Helsinki University Hospital,
University of Helsinki , Helsinki , Finland.
c Department of Clinical Physiology and Nuclear Medicine , HUS Medical Imaging
Center, Helsinki University Hospital, University of Helsinki , Helsinki , Finland.
d Department of Internal Medicine , Päijät-Häme Central Hospital , Lahti , Finland.
e Department of Health, Functional Capacity, and Welfare , National Institute for
Health and Welfare (Terveyden ja Hyvinvoinnin Laitos) , Helsinki , Finland.
f Department of Clinical Neurosciences/Neurology , Institute of Neuroscience and
Physiology, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University
Hospital , Gothenburg , Sweden.
g Medical Research Center Oulu , Oulu University Hospital, University of Oulu ,
Oulu , Finland.
AN - 28657357
AU - Pirinen, J.
AU - Eranti, A.
AU - Knekt, P.
AU - Lehto, M.
AU - Martinez-Majander, N.
AU - Aro, A. L.
AU - Rissanen, H.
AU - Heliövaara, M.
AU - Kaste, M.
AU - Tatlisumak, T.
AU - Huikuri, H.
AU - Putaala, J.
DA - Nov
DO - 10.1080/07853890.2017.1348620
DP - NLM
ET - 2017/06/29
IS - 7
J2 - Annals of medicine
KW - Adult
Atrial Fibrillation/*diagnosis
Biomarkers
Brain Ischemia/*diagnosis/epidemiology/etiology
Female
Humans
Hypertrophy, Left Ventricular/*diagnosis
Male
Middle Aged
Prevalence
Risk Factors
Stroke/*diagnosis/epidemiology/etiology
*Cardioembolism
*P-wave
*case-control study
*cryptogenic stroke
*electrocardiographic
*embolic strokes of undetermined source
*stroke
*stroke in the young
LA - eng
N1 - 1365-2060
Pirinen, Jani
Eranti, Antti
Knekt, Paul
Lehto, Mika
Martinez-Majander, Nicolas
Aro, Aapo L
Rissanen, Harri
Heliövaara, Markku
Kaste, Markku
Tatlisumak, Turgut
Huikuri, Heikki
Putaala, Jukka
Journal Article
England
Ann Med. 2017 Nov;49(7):562-568. doi: 10.1080/07853890.2017.1348620. Epub 2017 Jul
14.
PY - 2017
SN - 0785-3890
SP - 562-568
ST - ECG markers associated with ischemic stroke at young age - a case-control
study
T2 - Ann Med
TI - ECG markers associated with ischemic stroke at young age - a case-control
study
VL - 49
ID - 2344
ER -
TY - JOUR
AN - 14112650
AU - Placak, B.
AU - Prazak, M.
AU - Burda, J.
AU - Kalab, J.
AU - Bartak, L.
DA - Nov
DP - NLM
ET - 1963/11/01
J2 - Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti
KW - *Cardiac Surgical Procedures
*Heart Failure
*Hemorrhage
Humans
*Thoracic Surgery
*heart failure, congestive
*heart surgery
LA - cze
N1 - Placak, b
Prazak, m
Burda, j
Kalab, j
Bartak, l
Journal Article
Czech Republic
Rozhl Chir. 1963 Nov;42:764-74.
OP - Rozbor prvn'ich na sich 100 nemocn'ych operovan'ych pro mitr'aln'i sten'ozu.
PY - 1963
SN - 0035-9351 (Print)
0035-9351
SP - 764-74
ST - [ANALYSIS OF OUR 1ST 100 PATIENTS SURGICALLY TREATED FOR MITRAL STENOSIS]
T2 - Rozhl Chir
TI - [ANALYSIS OF OUR 1ST 100 PATIENTS SURGICALLY TREATED FOR MITRAL STENOSIS]
VL - 42
ID - 2862
ER -
TY - JOUR
AB - BACKGROUND: To investigate baseline characteristics and long-term prognosis
of carefully characterized asymptomatic and symptomatic patients with atrial
fibrillation (AF) in a 'real-world' cohort of first-diagnosed non-valvular AF over
a 10-year follow-up period. METHODS AND RESULTS: We conducted an observational,
non-interventional, and single-centre registry-based study of consecutive first-
diagnosed AF patients. Of 1100 patients (mean age 52.7±12.2 years and mean follow-
up 9.9±6.1 years), 146 (13.3%) had asymptomatic AF. Persistent or permanent AF,
slower ventricular rate during AF (<100/min), CHA2DS2-VASc score of 0, history of
diabetes mellitus and male gender were independent baseline risk factors for
asymptomatic AF presentation (all p<0.01) with a good predictive ability of the
multivariable model (c-statistic 0.86, p<0.001). Kaplan-Meier 10-year estimates of
survival free of progression of AF (log-rank test=33.4, p<0.001) and ischemic
stroke (log-rank test=6.2, p=0.013) were significantly worse for patients with
asymptomatic AF compared to those with symptomatic arrhythmia. In the multivariable
Cox regression analysis, intermittent asymptomatic AF was significantly associated
with progression to permanent AF (Hazard Ratio 1.6; 95% CI, 1.1-2.2; p=0.009).
CONCLUSIONS: In a 'real-world' setting, patients with asymptomatic presentation of
their first-diagnosed AF could have different risk profile and long-term outcomes
compared to those with symptomatic AF. Whether more intensive monitoring and
comprehensive AF management including AF ablation at early stage following the
incident episode of AF and increased quality of oral anticoagulation could alter
the long-term prognosis of these patients requires further investigation.
AD - Faculty of Medicine, University of Belgrade, Serbia; Cardiology Clinic,
Clinical Center of Serbia, 11000 Belgrade, Serbia. Electronic address:
tanjapotpara@gmail.com.
AN - 23958417
AU - Potpara, T. S.
AU - Polovina, M. M.
AU - Marinkovic, J. M.
AU - Lip, G. Y.
DA - Oct 12
DO - 10.1016/j.ijcard.2013.07.234
DP - NLM
ET - 2013/08/21
IS - 5
Atrial Fibrillation/*diagnosis/mortality/surgery
Catheter Ablation
Female
Follow-Up Studies
Humans
Incidence
Male
Middle Aged
Prognosis
Prospective Studies
*Registries
Risk Factors
Serbia/epidemiology
Stroke/epidemiology/etiology/prevention & control
Time Factors
Ablation of atrial fibrillation
Asymptomatic atrial fibrillation
Atrial fibrillation
First-diagnosed atrial fibrillation
Progression of atrial fibrillation
Stroke risk factors
LA - eng
N1 - 1874-1754
Potpara, Tatjana S
Polovina, Marija M
Marinkovic, Jelena M
Lip, Gregory Y H
Comparative Study
Journal Article
Observational Study
Netherlands
Int J Cardiol. 2013 Oct 12;168(5):4744-9. doi: 10.1016/j.ijcard.2013.07.234. Epub
2013 Aug 1.
PY - 2013
SN - 0167-5273
SP - 4744-9
ST - A comparison of clinical characteristics and long-term prognosis in
asymptomatic and symptomatic patients with first-diagnosed atrial fibrillation: the
Belgrade Atrial Fibrillation Study
T2 - Int J Cardiol
TI - A comparison of clinical characteristics and long-term prognosis in
asymptomatic and symptomatic patients with first-diagnosed atrial fibrillation: the
Belgrade Atrial Fibrillation Study
VL - 168
ID - 2609
ER -
TY - JOUR
AB - BACKGROUND: Mitral annular calcification (MAC) has been suggested as a
reliable, time-averaged marker of atherosclerosis and is associated with coronary
artery disease, heart failure, ischemic stroke, and increased mortality. Data on
the relationship between MAC and cardiovascular morbidity and mortality in atrial
fibrillation (AF) are sparse, with the exception of the relationship between MAC
and stroke. We investigated the association of MAC with cardiovascular morbidity,
stroke, cardiovascular mortality, and all-cause death in a cohort of middle-aged
patients with AF with a mean 10-year follow-up. METHODS: This was an observational
study of patients with nonvalvular AF between 1992 and 2007. RESULTS: Of 1,056
patients, 33 (3.1%) had MAC; they were more likely to be older and female and to
have a dilated left atrium, reduced left ventricular ejection fraction, permanent
AF, hypertension, and/or diabetes mellitus (all P < .05). Total follow-up was
10,418.5 years (mean, 9.9 ± 5.9 years), and the mean age was 52.7 ± 12.2 years. In
univariate analysis, MAC was associated with all-cause death, cardiovascular death,
stroke, new cardiac morbidity (all P < .05), and the composite end point of
ischemic stroke, myocardial infarction (MI), and all-cause death (P < .001). In
multivariate analyses, MAC was related to all-cause death (hazard ratio [HR], 4.3;
95% CI, 1.8-10.0; P < .001), cardiovascular death (HR, 3.5; 95% CI, 1.2-10.4; P = .
025), the composite end point (HR, 2.1; 95% CI, 1.0-4.3; P = .048), and new cardiac
morbidity (HR, 2.4; 95% CI, 1.3-4.5; P = .005). There was no significant
relationship between MAC and stroke or MI in the multivariate analyses.
CONCLUSIONS: MAC is associated with increased cardiovascular morbidity,
cardiovascular mortality, and all-cause mortality of patients with AF. MAC should
be acknowledged as a marker of increased cardiovascular risk in middle-aged
patients with AF.
AD - Cardiology Clinic, Clinical Center of Serbia, Serbia. Electronic address:
spotpara@sbb.rs.
Cardiology Clinic, Clinical Center of Serbia, Serbia; Faculty of Medicine,
University of Belgrade, Serbia.
Institute for Medical Statistics, University of Belgrade, Serbia.
Cardiology Clinic, Clinical Center of Serbia, Serbia.
Birmingham, England.
AN - 21436252
AU - Potpara, T. S.
AU - Vasiljevic, Z. M.
AU - Vujisic-Tesic, B. D.
AU - Marinkovic, J. M.
AU - Polovina, M. M.
AU - Stepanovic, J. M.
AU - Stankovic, G. R.
AU - Ostojic, M. C.
AU - Lip, G. Y. H.
DA - Oct
DO - 10.1378/chest.10-2963
DP - NLM
ET - 2011/03/26
IS - 4
J2 - Chest
KW - Adult
Aged
Calcinosis/*complications
Cardiovascular Diseases/*epidemiology/*mortality
Female
Follow-Up Studies
Heart Valve Diseases/*complications
Humans
Male
Middle Aged
*Mitral Valve
Myocardial Infarction/epidemiology/mortality
Risk Factors
Serbia
Survival Rate
LA - eng
N1 - 1931-3543
Potpara, Tatjana S
Vasiljevic, Zorana M
Vujisic-Tesic, Bosiljka D
Marinkovic, Jelena M
Polovina, Marija M
Stepanovic, Jelena M
Stankovic, Goran R
Ostojic, Miodrag C
Lip, Gregory Y H
Journal Article
United States
Chest. 2011 Oct;140(4):902-910. doi: 10.1378/chest.10-2963. Epub 2011 Mar 24.
PY - 2011
SN - 0012-3692
SP - 902-910
ST - Mitral annular calcification predicts cardiovascular morbidity and mortality
in middle-aged patients with atrial fibrillation: the Belgrade Atrial Fibrillation
Study
T2 - Chest
TI - Mitral annular calcification predicts cardiovascular morbidity and mortality
in middle-aged patients with atrial fibrillation: the Belgrade Atrial Fibrillation
Study
VL - 140
ID - 2675
ER -
TY - JOUR
AB - BACKGROUND: As cardiovascular clinical trials improve in sophistication and
therapies target specific cardiac mechanisms of death, a more objective and precise
system to identify specific cause of death is needed. Ideally, sudden cardiac death
would describe patients dying of ventricular tachycardia and ventricular
fibrillation. In this context, we explored the precision of current sudden death
classification and implications for clinical trials. METHODS AND RESULTS: Deaths
were analyzed in 834 patients who received an automatic implantable cardioverter-
defibrillator (ICD). Three arrhythmia experts used a standard prospective
classification system to classify deaths into accepted categories: sudden cardiac,
nonsudden cardiac, and noncardiac. New aspects to this study included analysis of
autopsy results and ICD interrogation for arrhythmias at the time of death. All of
the patients receiving the ICD previously had documented sustained ventricular
tachycardia/fibrillation or cardiac arrest. Of the 109 subsequent deaths in the
834-patient database, 17 (16%) were classified as sudden cardiac. Compared with the
nonsudden cardiac and noncardiac categories, sudden cardiac death was more often
identified in outpatients (59% versus 10%) and witnessed less often (41% versus
86%; both P < .001). The autopsy information contradicted and changed the clinical
perception of a "sudden cardiac death" in 7 cases (myocardial infarction [n = 1],
pulmonary embolism [n = 2], cerebral infarction [n = 1], ruptured thoracic [n = 1],
and abdominal aortic aneurysms [n = 2]). Interpretable ICD interrogation was
available in 53% of the deaths (47% unavailable: buried, programmed off, or other
technical reasons). When evaluated, only 7 of 17 "sudden deaths" were associated
with ICD discharges near the time of death. CONCLUSIONS: Even in a group of
patients with an ICD, deaths classified as sudden cardiac frequently were not
associated with ventricular tachycardia or ventricular fibrillation and were often
noncardiac. It is possible to create a wide range of sudden cardiac death rates
(more than fourfold) using the identical clinical database despite objective,
prespecified criteria. Autopsy results frequently reveal noncardiac causes of
clinical events simulating sudden cardiac death. ICD interrogation revealed that
ICD discharges were often related to terminal arrhythmias incidental to the primary
pathophysiological process leading to death.
AD - Department of Medicine, Baylor College of Medicine, Houston, Tex 77030, USA.
AN - 8565170
AU - Pratt, C. M.
AU - Greenway, P. S.
AU - Schoenfeld, M. H.
AU - Hibben, M. L.
AU - Reiffel, J. A.
DA - Feb 1
DO - 10.1161/01.cir.93.3.519
DP - NLM
ET - 1996/02/01
IS - 3
J2 - Circulation
KW - Cause of Death
Death, Sudden
*Death, Sudden, Cardiac
Female
Heart Arrest
Humans
Male
Middle Aged
Tachycardia, Ventricular/mortality
Ventricular Fibrillation/mortality
LA - eng
N1 - Pratt, C M
Greenway, P S
Schoenfeld, M H
Hibben, M L
Reiffel, J A
Journal Article
United States
Circulation. 1996 Feb 1;93(3):519-24. doi: 10.1161/01.cir.93.3.519.
PY - 1996
SN - 0009-7322 (Print)
0009-7322
SP - 519-24
ST - Exploration of the precision of classifying sudden cardiac death.
Implications for the interpretation of clinical trials
T2 - Circulation
TI - Exploration of the precision of classifying sudden cardiac death.
Implications for the interpretation of clinical trials
VL - 93
ID - 2720
ER -
TY - JOUR
AB - In part VI of a series of papers on epidemiology and drug prevention of
stroke and other thromboembolic complications of atrial fibrillation the authors
analyze data of randomized trials comparing various approaches to the treatment of
atrial fibrillation: cardioversion with subsequent use of antiarrhythmic drugs for
maintenance of sinus rhythm and control of rate of ventricular rhythm with
obligatory concomitant use of anticoagulants. Approach aimed at sinus rhythm
maintenance by means of repetitive cardioversions and long term antiarrhythmic
therapy has not been associated with lowering of mortality, rates of stroke or
other thromboembolic complications. The use of antithrombotic drugs represent a
sole reliable method of stroke prevention in patients with persistent and chronic
AF. The paper contains consideration of indications for prescription of warfarin
and aspirin to these patients.
AN - 15699946
AU - Preobrazhenskiĭ, D. V.
AU - Sidorenko, B. A.
AU - Kiktëv, V. G.
AU - Batyraliev, T. A.
AU - Pershukov, I. V.
DP - NLM
ET - 2005/02/09
IS - 1
J2 - Kardiologiia
Atrial Fibrillation/*complications/drug therapy/*therapy
Humans
LA - rus
N1 - Preobrazhenskiĭ, D V
Sidorenko, B A
Kiktëv, V G
Batyraliev, T A
Pershukov, I V
English Abstract
Journal Article
Review
Russia (Federation)
Kardiologiia. 2005;45(1):84-93.
PY - 2005
SN - 0022-9040 (Print)
0022-9040
SP - 84-93
ST - [Stroke and other thromboembolic complications of atrial fibrillation. Part
VI. Choice of optimal approach and drugs for prevention of stroke]
T2 - Kardiologiia
TI - [Stroke and other thromboembolic complications of atrial fibrillation. Part
VI. Choice of optimal approach and drugs for prevention of stroke]
VL - 45
ID - 2570
ER -
TY - JOUR
AB - BACKGROUND AND PURPOSE: In the first 3 months after acute ischemic stroke, 2%
to 6% of patients die from cardiac causes. This may reflect preexisting cardiac
disease, cardiac dysfunction related to the acute neurohumoral and autonomic stress
response to stroke, or both. Delineation of a high-risk group could facilitate
prevention strategies. We aimed to describe the temporal profile of cardiac risk
after stroke and develop a predictive model of serious cardiac adverse events
(SCAEs) using baseline variables. METHODS: We used data from the one trial in the
Virtual International Stroke Trials Archive that matched prespecified criteria.
Survival analysis was used to describe the temporal profile of cardiac events after
stroke. Prognostic determinants were assessed with multivariable logistic
regression, and a risk score was derived from the key predictor variables. RESULTS:
Of 846 ischemic stroke patients, 35 (4.1%) died from cardiac causes and 161 (19.0%)
suffered at least one SCAE. The hazard of cardiac death was highest (0.001/d) in
the second week. Hazard of a first SCAE peaked at 0.02/d between day 2 and 3. The 5
factors most predictive of SCAEs were a history of heart failure (OR 3.33 [2.28,
4.89], P<0.001), diabetes (OR 2.11 [1.39, 3.21], P<0.001), baseline creatinine >115
micromol/L (OR 1.77 [1.16, 2.70], P=0.008), severe stroke (OR 1.98 [1.34,2.91],
P=0.001), and a long QTc or ventricular extrasystoles on ECG (OR 1.93 [1.31, 2.85],
P=0.001). Risk of SCAEs ranged from 6.3% (no predictors) to 62.2% (> or =4
predictors). CONCLUSIONS: Serious cardiac events are common in the acute period
after stroke. Patients at highest risk are identifiable and may benefit from more
aggressive strategies to improve survival.
AD - Department of Neurology, Royal Melbourne Hospital, Grattan Street, Parkville,
Victoria, Australia.
AN - 17569877
AU - Prosser, J.
AU - MacGregor, L.
AU - Lees, K. R.
AU - Diener, H. C.
AU - Hacke, W.
AU - Davis, S.
DA - Aug
DO - 10.1161/strokeaha.106.471813
DP - NLM
ET - 2007/06/16
IS - 8
J2 - Stroke
KW - Aged
Aged, 80 and over
Brain Ischemia/*mortality/physiopathology
Causality
Comorbidity
Creatinine/blood
*Death
Female
Heart Diseases/*mortality/*physiopathology
Heart Failure/epidemiology/physiopathology
Humans
Male
Risk Factors
Stroke/*mortality/physiopathology
Survival Analysis
Time Factors
Ventricular Premature Complexes/epidemiology/physiopathology
LA - eng
N1 - 1524-4628
Prosser, Jane
MacGregor, Lachlan
Lees, Kennedy R
Diener, Hans-Christoph
Hacke, Werner
Davis, Stephen
VISTA Investigators
Journal Article
Meta-Analysis
United States
Stroke. 2007 Aug;38(8):2295-302. doi: 10.1161/STROKEAHA.106.471813. Epub 2007 Jun
14.
PY - 2007
SN - 0039-2499
SP - 2295-302
ST - Predictors of early cardiac morbidity and mortality after ischemic stroke
T2 - Stroke
TI - Predictors of early cardiac morbidity and mortality after ischemic stroke
VL - 38
ID - 2450
ER -
TY - JOUR
AB - IMPORTANCE: Atrial fibrillation is a common arrhythmia that affects more than
2.5 million people in the United States and causes substantial morbidity and
mortality, especially regarding the increased risk of stroke. OBJECTIVE: To
summarize atrial fibrillation treatment exclusive of stroke prevention. EVIDENCE
REVIEW: An Ovid MEDLINE comprehensive literature search was performed on atrial
fibrillation therapy excluding anticoagulation and emphasizing studies published
within the last 5 years through April 2015 (N = 5044 references). The 2014 atrial
fibrillation guideline from the American Heart Association, the American College of
Cardiology, and the Heart Rhythm Society also was reviewed. FINDINGS: Reversible
causes of atrial fibrillation should be identified. Risk factor modification,
including weight loss and treatment of hypertension, diabetes, and obstructive
sleep apnea can reduce atrial fibrillation episodes. Appropriate anticoagulation is
necessary for patients at substantial stroke risk regardless of rate or rhythm
treatment strategy. Sinus rhythm is often needed to control symptoms; however, an
alternative strategy for atrial fibrillation is appropriate rate control. Rate
control is safe in older patients (those who are about age ≥65 years) followed up
for a few years, but no such safety data exist for patients younger than 60 years
or for those followed up for longer periods. Thus, selection of therapy is
individualized, taking into account present and future medical problems for the
patient. Choice of an antiarrhythmic drug is based on safety first vs efficacy.
Catheter ablation is an effective nonpharmacological alternative that is often, but
not always, the second-line treatment. Reduction of the frequency and duration of
atrial fibrillation episodes that result in a significant improvement in quality of
life is a good marker of drug treatment success and complete elimination of atrial
fibrillation is not required in many patients. Rate control is usually achieved
with a β-blocker or non-dihydropyridine calcium channel blockers. It is important
to assess adequate rate control during both rest and activity. If the ventricular
rate goes uncontrolled for a prolonged period, tachycardia-mediated cardiomyopathy
can occur. CONCLUSIONS AND RELEVANCE: Therapy for atrial fibrillation includes
prevention and modification of inciting causes and appropriate anticoagulation.
Rate control is necessary for all patients. Maintenance of sinus rhythm with drugs
or catheter ablation should be considered based on the individual needs of each
patient.
AD - St Vincent Medical Group, St Vincent Hospital, Indianapolis, Indiana.
AN - 26197188
AU - Prystowsky, E. N.
AU - Padanilam, B. J.
AU - Fogel, R. I.
DA - Jul 21
DO - 10.1001/jama.2015.7505
DP - NLM
ET - 2015/07/22
IS - 3
J2 - Jama
Algorithms
Atrial Fibrillation/complications/*drug therapy/surgery
*Catheter Ablation
Electrocardiography
Female
*Heart Rate
Humans
Male
Risk Factors
LA - eng
N1 - 1538-3598
Prystowsky, Eric N
Padanilam, Benzy J
Fogel, Richard I
Journal Article
Review
United States
JAMA. 2015 Jul 21;314(3):278-88. doi: 10.1001/jama.2015.7505.
PY - 2015
SN - 0098-7484
SP - 278-88
ST - Treatment of Atrial Fibrillation
T2 - Jama
TI - Treatment of Atrial Fibrillation
VL - 314
ID - 2284
ER -
TY - JOUR
AB - A case of 'primary' mitral valve prolapse is documented. The patient was
admitted with right-sided hemiplegia of sudden onset, probably caused by a cerebral
embolus from the mitral valve. He also had a painless transmural inferior
myocardial infarction (MI) of indeterminate age which was diagnosed
electrocardiographically and on left ventricular cine angiography. Since selective
coronary arteriography delineated the absence of fixed obstructive atherosclerotic
disease, and since coronary vasospasm could not be provoked with the ergonovine
(ergometrine) maleate test, it is further postulated that a coronary embolus from
the abnormal mitral valve apparatus was responsible for the painless MI. A
percutaneous right ventricular endomyocardial biopsy specimen displayed findings
not indicative of a 'cardiomyopathy'.
AN - 6701695
AU - Przybojewski, J. Z.
AU - Tredoux, J. G.
AU - van der Walt, J. J.
AU - Tiedt, F. A.
DA - Mar 10
DP - NLM
ET - 1984/03/10
IS - 10
KW - Adult
Cineangiography
Electrocardiography
Hemiplegia/etiology
Humans
Intracranial Embolism and Thrombosis/*complications
Male
Mitral Valve Prolapse/*complications/diagnosis
Myocardial Infarction/*complications/pathology
Pain/physiopathology
LA - eng
N1 - Przybojewski, J Z
Tredoux, J G
van der Walt, J J
Tiedt, F A
Case Reports
Journal Article
South Africa
S Afr Med J. 1984 Mar 10;65(10):390-6.
PY - 1984
SN - 0256-9574 (Print)
SP - 390-6
ST - Mitral valve prolapse complicated by acute cerebral embolism, arrhythmias and
painless myocardial infarction. A case presentation and overview
T2 - S Afr Med J
TI - Mitral valve prolapse complicated by acute cerebral embolism, arrhythmias and
painless myocardial infarction. A case presentation and overview
VL - 65
ID - 2910
ER -
TY - JOUR
AB - A 64-year-old white woman with moderately severe rheumatic mitral stenosis
complicated by atrial fibrillation and recurrent systemic embolisation to the brain
was found at operation to have a large 'free-floating' left atrial thrombus, as
well as multiple left atrial appendage thrombi. These had not been detected by
echocardiography. She also had significantly reduced left ventricular contractility
on cine angiography, and right coronary artery atherosclerosis. She underwent
successful mitral valve replacement and excision of the left atrial appendage.
AN - 3810372
AU - Przybojewski, J. Z.
AU - Vogts, B. C.
AU - Hunter, J.
AU - Knott-Craig, C. J.
DA - Feb 7
DP - NLM
ET - 1987/02/07
IS - 3
Cineangiography
Echocardiography
Embolism/*complications
Female
Heart Diseases/*complications/surgery
Humans
Middle Aged
Mitral Valve Stenosis/*complications/surgery
Recurrence
Thrombosis/*complications
LA - eng
N1 - Przybojewski, J Z
Vogts, B C
Hunter, J
Knott-Craig, C J
Case Reports
Journal Article
South Africa
S Afr Med J. 1987 Feb 7;71(3):186-8.
PY - 1987
SN - 0256-9574 (Print)
SP - 186-8
ST - Mitral stenosis with free-floating left atrial thrombus and recurrent
systemic embolisation. A case report
T2 - S Afr Med J
TI - Mitral stenosis with free-floating left atrial thrombus and recurrent
systemic embolisation. A case report
VL - 71
ID - 3006
ER -
TY - JOUR
AB - BACKGROUND: To determine the cardiological substrate in acute stroke patients
presenting with a cardioembolic stroke subtype. METHODS: Data of 402 consecutive
patients with cardioembolic stroke (cerebral infarction, n=347; transient ischaemic
attack, n=55) were collected from a prospective hospital-based stroke registry in
which data on 2000 stroke patients over a 10-year period were included. In all
patients, specific cardiac disorders were identified by physical examination and
results of electrocardiography and transthoracic echocardiography. Holter
monitoring and more sensitive techniques of cardiac imaging were used in selected
cases. RESULTS: Cardioembolic cerebral ischaemia accounted for 20% of all acute
strokes (25% of ischaemic cerebrovascular events). Cardiac sources of embolism
included the following: (a) structural cardiac disorders associated with arrhythmia
(n=232), the most frequent being left ventricular hypertrophic hypertensive disease
(n=120) and rheumatic mitral valve disease (n=49); (b) structural cardiac disease
with sustained sinus rhythm (n=81), the most frequent being systolic left
ventricular dysfunction of both ischaemic (n=35) or non-ischaemic (n=24) aetiology;
and (c) isolated atrial dysrhythmia (atrial fibrillation, n=88 and atrial flutter,
n=1). CONCLUSIONS: Hypertrophic hypertensive cardiac disease complicated with
atrial fibrillation was the most frequent cardiac source of emboli in cardioembolic
stroke. Other important cardiac sources were isolated atrial fibrillation,
rheumatic mitral valve disease, and systolic left ventricular dysfunction of
ischaemic and non-ischaemic cause. The incidence of traditional emboligenous-prone
cardiac disorders, such as mitral valve prolapse and mitral annular calcification
was low.
AD - Service of Cardiology, Hospital del Sagrat Cor, C/ Viladomat 288, E-08029
Barcelona, Spain. aarboixd@meditex.es
AN - 15193810
AU - Pujadas Capmany, R.
AU - Arboix, A.
AU - Casañas-Muñoz, R.
AU - Anguera-Ferrando, N.
DA - Jun
DO - 10.1016/j.ijcard.2003.02.007
DP - NLM
ET - 2004/06/15
IS - 2-3
KW - Aged
Cerebral Infarction/epidemiology/*etiology
Female
Heart Diseases/*epidemiology
Humans
Intracranial Embolism/epidemiology/*etiology
Ischemic Attack, Transient/epidemiology/*etiology
Male
Prospective Studies
Spain/epidemiology
LA - eng
N1 - Pujadas Capmany, Ramón
Arboix, Adrià
Casañas-Muñoz, Roser
Anguera-Ferrando, Nuria
Journal Article
Netherlands
Int J Cardiol. 2004 Jun;95(2-3):129-34. doi: 10.1016/j.ijcard.2003.02.007.
PY - 2004
SN - 0167-5273 (Print)
0167-5273
SP - 129-34
ST - Specific cardiac disorders in 402 consecutive patients with ischaemic
T2 - Int J Cardiol
TI - Specific cardiac disorders in 402 consecutive patients with ischaemic
VL - 95
ID - 2569
ER -
TY - JOUR
AB - BACKGROUND: Despite many prospective randomized studies defining the benefits
of anticoagulation in atrial fibrillation (AF), there have been no adequate studies
in cardiomyopathy (CM) in sinus rhythm. METHODS: We review the current knowledge of
the risk of stroke in CM, left ventricular systolic dysfunction and heart failure
as well as the indications for antithrombotic agents and compare this with AF.
RESULTS: The current knowledge of risk factors for stroke and indications for
antithrombotic agents in CM is similar to that of AF prior to the treatment studies
of the 1980s-1990s. CONCLUSION: Prospective randomized trial data are urgently
needed to determine the role of antithrombotic drugs in CM.
AD - Kent Institute of Medicine and Health Sciences, University of Kent,
Canterbury, Kent, UK. P.Pullicino@kent.ac.uk
AN - 18667814
AU - Pullicino, P.
AU - Thompson, J. L.
AU - Mohr, J. P.
AU - Sacco, R. L.
AU - Freudenberger, R.
AU - Levin, B.
AU - Homma, S.
DO - 10.1159/000149581
DP - NLM
ET - 2008/08/01
IS - 3
Cardiomyopathies/complications/*drug therapy
Fibrinolytic Agents/*administration & dosage
Humans
Patient Selection
Risk Assessment
Risk Factors
Stroke/etiology/mortality/*prevention & control
Treatment Outcome
Ventricular Dysfunction, Left/complications/*drug therapy
LA - eng
N1 - 1421-9786
Pullicino, P
Thompson, J L P
Mohr, J P
Sacco, R L
Freudenberger, R
Levin, B
Homma, S
Journal Article
Review
Switzerland
Cerebrovasc Dis. 2008;26(3):322-7. doi: 10.1159/000149581. Epub 2008 Jul 31.
PY - 2008
SN - 1015-9770
SP - 322-7
ST - Oral anticoagulation in patients with cardiomyopathy or heart failure in
sinus rhythm
TI - Oral anticoagulation in patients with cardiomyopathy or heart failure in
sinus rhythm
VL - 26
ID - 2716
ER -
TY - JOUR
AB - BACKGROUND AND PURPOSE: Data on cardiac complications and their precipitants
after intracerebral hemorrhage are scarce. We examined the frequency and risk
factors for serious in-hospital cardiac events in a large cohort of consecutive
intracerebral hemorrhage patients. METHODS: A retrospective chart review of 1013
consecutive patients with nontraumatic intracerebral hemorrhage treated at the
Helsinki University Central Hospital (2005-2010). We excluded patients with
intraparenchymal hematoma related to sub-arachnoid hemorrhage or intracerebral
hemorrhage because of fibrinolytic therapies for acute ischemic stroke or
myocardial infarction. Serious in-hospital cardiac event was defined as any of in-
hospital poststroke acute myocardial infarction, ventricular fibrillation or
tachycardia, moderate to serious acute heart failure, or cardiac death. RESULTS:
Among the 948 patients included, ≥1 serious in-hospital cardiac event occurred in
39 (4·1%) patients after a median delay of two-days from stroke onset (acute
myocardial infarction in three patients, ventricular fibrillation or tachycardia in
three patients, acute heart failure in 36 patients, and cardiac death in three
patients). Hospital stay was longer in patients with serious in-hospital cardiac
event than in those without (median 12, interquartile range 7-19 vs. 8, 3-14; P =
0·001), with no difference in in-hospital mortality (23·1% vs. 24·3%; P = 0·86). In
multivariable logistic regression analysis adjusted for age, gender, and diabetes,
atrial fibrillation during hospitalization (odds ratio 6·68 for new-onset atrial
fibrillation, 95% confidence interval 2·11-21·18; 4·46 for old atrial fibrillation,
2·08-9·56), and history of myocardial infarction (3·20, 1·18-8·66) were
independently associated with serious in-hospital cardiac events. CONCLUSIONS:
After intracerebral hemorrhage, 4% of patients suffer an acute serious cardiac
complication. Those with history of myocardial infarction or in-hospital atrial
fibrillation are at greater risk for such events.
AD - Department of Neurology, Helsinki University Central Hospital, Helsinki,
Finland.
AN - 24025067
AU - Putaala, J.
AU - Lehto, M.
AU - Meretoja, A.
AU - Silvennoinen, K.
AU - Curtze, S.
AU - Kääriäinen, J.
AU - Koivunen, R. J.
AU - Kaste, M.
AU - Tatlisumak, T.
AU - Strbian, D.
DA - Aug
DO - 10.1111/ijs.12180
DP - NLM
ET - 2013/09/13
IS - 6
J2 - International journal of stroke : official journal of the International
Stroke Society
KW - Aged
Cerebral Hemorrhage/*complications/*epidemiology/physiopathology
Electrocardiography
Female
Heart Diseases/*complications/*epidemiology/physiopathology
Hospital Mortality
*Hospitalization
Humans
Logistic Models
Male
Middle Aged
Registries
Risk Factors
Stroke/complications/epidemiology/physiopathology
atrial fibrillation
cardiac arrhythmia
heart failure
intracerebral hemorrhage
LA - eng
N1 - 1747-4949
Putaala, J
Lehto, M
Meretoja, A
Silvennoinen, K
Curtze, S
Kääriäinen, J
Koivunen, R-J
Kaste, M
Tatlisumak, T
Strbian, D
Journal Article
Observational Study
United States
Int J Stroke. 2014 Aug;9(6):741-6. doi: 10.1111/ijs.12180. Epub 2013 Sep 12.
PY - 2014
SN - 1747-4930
SP - 741-6
ST - In-hospital cardiac complications after intracerebral hemorrhage
T2 - Int J Stroke
TI - In-hospital cardiac complications after intracerebral hemorrhage
VL - 9
ID - 2557
ER -
TY - JOUR
AB - OBJECTIVES: The goals of this study were to determine: 1) if low-risk
patients assessed by a CHADS(2) score, a clinical scoring system quantifying a risk
of stroke in patients with atrial fibrillation (AF), require a routine screening
transesophageal echocardiogram (TEE) before pulmonary vein isolation (PVI); and 2)
the relationship of a CHADS(2) score with left atrial (LA)/left atrial appendage
(LAA) spontaneous echo contrast, sludge, and thrombus. BACKGROUND: There is no
clear consensus of whether a screening TEE before catheter ablation of AF should be
performed in every patient. METHODS: Initial TEEs for pre-PVI of 1,058 AF patients
(age 57 +/- 11 years, 80% men) were reviewed and compared with a CHADS(2) score.
RESULTS: CHADS(2) scores of 0, 1, 2, 3, 4, 5, and 6 were present in 47%, 33%, 14%,
5%, 1%, 0.3%, and 0% of patients, respectively. The prevalence of LA/LAA thrombus,
sludge, and spontaneous echo contrast were present in 0.6%, 1.5%, and 35%. The
prevalence of LA/LAA thrombus/sludge increased with ascending CHADS(2) score
(scores 0 [0%], 1 [2%], 2 [5%], 3 [9%], and 4 to 6 [11%], p < 0.01). No patient
with a CHADS(2) score of 0 had LA/LAA sludge/thrombus. In a multivariate model,
history of congestive heart failure and left ventricular ejection fraction <35%
were significantly associated with sludge/thrombus. CONCLUSIONS: The prevalence of
LA/LAA sludge/thrombus in patients with AF undergoing a pre-PVI screening TEE is
very low (<2%) and increases significantly with higher CHADS(2) scores. This
suggests that a screening TEE before PVI should be performed in patients with a
CHADS(2) score of >or=1, and in patients with a CHADS(2) score of 0 when the AF is
persistent and therapeutic anticoagulation has not been maintained for 4 weeks
before the procedure.
AD - Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio
44195, USA.
AN - 19926009
AU - Puwanant, S.
AU - Varr, B. C.
AU - Shrestha, K.
AU - Hussain, S. K.
AU - Tang, W. H.
AU - Gabriel, R. S.
AU - Wazni, O. M.
AU - Bhargava, M.
AU - Saliba, W. I.
AU - Thomas, J. D.
AU - Lindsay, B. D.
AU - Klein, A. L.
DA - Nov 24
DO - 10.1016/j.jacc.2009.07.037
DP - NLM
ET - 2009/11/21
IS - 22
KW - Aged
Atrial Appendage/diagnostic imaging
Atrial Fibrillation/diagnostic imaging/*epidemiology/surgery
Catheter Ablation
Female
Humans
Male
Middle Aged
Risk Assessment
Stroke Volume
Thromboembolism/*epidemiology
LA - eng
N1 - 1558-3597
Puwanant, Sarinya
Varr, Brandon C
Shrestha, Kevin
Hussain, Sarah K
Tang, W H Wilson
Gabriel, Ruvin S
Wazni, Oussama M
Bhargava, Mandeep
Saliba, Walid I
Thomas, James D
Lindsay, Bruce D
Klein, Allan L
Journal Article
United States
J Am Coll Cardiol. 2009 Nov 24;54(22):2032-9. doi: 10.1016/j.jacc.2009.07.037.
PY - 2009
SN - 0735-1097
SP - 2032-9
ST - Role of the CHADS2 score in the evaluation of thromboembolic risk in patients
with atrial fibrillation undergoing transesophageal echocardiography before
pulmonary vein isolation
TI - Role of the CHADS2 score in the evaluation of thromboembolic risk in patients
with atrial fibrillation undergoing transesophageal echocardiography before
pulmonary vein isolation
VL - 54
ID - 2679
ER -
TY - JOUR
AB - IMPORTANCE: The risk of ischemic stroke during periods of warfarin
discontinuation for surgical procedures is recognized but not well characterized.
OBJECTIVE: The study aimed to quantitate the risk of ischemic stroke associated
with high risk atrial fibrillation during periods of warfarin discontinuation.
DESIGN, SETTING AND PARTICIPANTS: A cohort of 4,060 patients (mean follow-up period
of 3.5 ± 1.3 years) were randomized into the Atrial Fibrillation Follow-Up
Investigation of Rhythm Management study. Patients enrolled in the study had atrial
fibrillation plus at least one other risk factor for stroke or death: age ≥65
years', systemic hypertension, diabetes mellitus, congestive heart failure,
transient ischemic attack, prior stroke, left atrium >50 mm, left ventricular
fractional shortening <25% or left ventricular ejection fraction <40%. EXPOSURE:
Warfarin discontinuation for procedure. MAIN OUTCOME AND MEASURES: The association
of warfarin discontinuation with the incidence of ischemic stroke using pooled
repeated measures and Cox proportional hazards analyses during follow-up after
adjusting for age, gender, obesity, diabetes mellitus, hypercholesterolemia,
cigarette smoking and study period. RESULTS: Warfarin discontinuation for procedure
occurred in 265 (0.4%) of the 71,355 person observations. Compared with those
without warfarin discontinuation, the rate of ischemic stroke was higher among
participants with surgery-related warfarin discontinuation (1.1% of 265 person
observations vs. 0.2% of 71,090 person observations, p = 0.001). Warfarin
discontinuation was associated with an increased risk for ischemic stroke (relative
risk 5.8; 95% CI 1.8-18.4) after adjusting for potential confounders. The
population-attributable risk associated with surgery-related warfarin
discontinuation was estimated to be 23.1% (95% CI 15.2-30.9%) for ischemic stroke.
CONCLUSIONS AND RELEVANCE: The 6-fold higher risk of ischemic stroke associated
with discontinuation of warfarin for surgical procedures must be recognized in high
risk atrial fibrillation patients and considered in the risk-benefit analysis of
any procedure.
AD - Zeenat Qureshi Stroke Institute (ZQSI), St. Cloud, Minn., USA.
AN - 27322535
AU - Qureshi, A. I.
AU - Jahangir, N.
AU - Malik, A. A.
AU - Afzal, M. R.
AU - Orfi, F.
AU - Suri, M. F.
DO - 10.1159/000446406
DP - NLM
ET - 2016/06/21
IS - 5-6
KW - Aged
Atrial Fibrillation/diagnosis/*drug therapy/epidemiology
Brain Ischemia/diagnosis/epidemiology/*prevention & control
Female
Humans
Incidence
Male
Middle Aged
Perioperative Care
Risk Assessment
Risk Factors
Stroke/diagnosis/epidemiology/*prevention & control
*Surgical Procedures, Operative
Time Factors
Treatment Outcome
Warfarin/*administration & dosage/adverse effects
LA - eng
N1 - 1421-9786
Qureshi, Adnan I
Jahangir, Nauman
Malik, Ahmed A
Afzal, Mohammad Rauf
Orfi, Fayyaz
Suri, M Fareed K
Journal Article
Switzerland
Cerebrovasc Dis. 2016;42(5-6):346-351. doi: 10.1159/000446406. Epub 2016 Jun 21.
PY - 2016
SN - 1015-9770
SP - 346-351
ST - Risk of Ischemic Stroke in High Risk Atrial Fibrillation Patients during
Periods of Warfarin Discontinuation for Surgical Procedures
TI - Risk of Ischemic Stroke in High Risk Atrial Fibrillation Patients during
Periods of Warfarin Discontinuation for Surgical Procedures
VL - 42
ID - 2461
ER -
TY - JOUR
AB - The clinical effects of transesophageal atrial pacing (TAP) were assessed in
308 patients. Indications for TAP included evaluation for pacemaker implantation in
patients suspected of sinus node dysfunction and determination of the suitable type
of pacemaker. Most patients underwent program stimulation including rapid as well
as burst stimulation. In one patient, following the study, cerebral arterial
embolism occurred, most likely secondary to an induced arrhythmia. That was the
only single case of permanent consequences following TAP. Additionally, one patient
was accidentally stimulated in the ventricle using low voltage electric current
that induced ventricular fibrillation. This was promptly reversed with
defibrillation. Twenty-six patients in whom an arrhythmia was previously induced,
required medical therapy, two of whom required cardioversion, and 24 required drug
therapy, subsequent to clinical intolerance of the arrhythmia. No lethal
complications occurred.
AD - Cardiological Department of IIIrd Internal Clinic, Medical Acadamy of Gdansk,
Poland.
AN - 1704591
AU - Raczak, G.
AU - Swiatecka, G.
AU - Lubinski, A.
AU - Kubica, J.
DA - Dec
DO - 10.1111/j.1540-8159.1990.tb06940.x
DP - NLM
ET - 1990/12/01
IS - 12 Pt 2
KW - Adult
Aged
Aged, 80 and over
Bradycardia/*diagnosis/physiopathology
Cardiac Pacing, Artificial/*adverse effects/methods
Electrocardiography
Electrodes
Esophagus
Female
Humans
Male
Middle Aged
Sinoatrial Node/physiopathology
Syndrome
Tachycardia/*diagnosis/physiopathology
Time Factors
LA - eng
N1 - Raczak, G
Swiatecka, G
Lubinski, A
Kubica, J
Journal Article
United States
Pacing Clin Electrophysiol. 1990 Dec;13(12 Pt 2):2048-53. doi: 10.1111/j.1540-
8159.1990.tb06940.x.
PY - 1990
SN - 0147-8389 (Print)
0147-8389
SP - 2048-53
ST - Transesophageal atrial pacing complications in patients suspected of tachy-
brady syndrome
TI - Transesophageal atrial pacing complications in patients suspected of tachy-
brady syndrome
VL - 13
ID - 2766
ER -
TY - JOUR
AB - Heart and brain vascular diseases present leading causes of death in
civilized world. During development of brain ischemia cardiac complications are
possible. The aim of this study was to determine the existence of cardiac
complications' clinical predictors by assessing certain electrocardiographic
changes in patients with acute ischemic brain disease (AIBD). Forty patients with
AIBD, without previous coronary disease history were included in the study. All
patients underwent 24 hour Holter monitoring during first 48 hours after the onset
of AIBD which was diagnosed by computerized brain tomography. ECG-s were analyzed
by computer and interpreted by the same cardiologist. Independent variables in
statistical analyses were: age, AIBD, cardiological therapy atherosclerosis risk
factors, heart disease history, degree of severity and lateralization of
neurological incident and maximal arterial blood pressure values. Dependent
variables were: presence/absence of ST depression and presence/absence of
ventricular arrhythmias (VA). All parameters as well as their interreaction, were
statistically analyzed. Results point that age and side of neurological incident
present independent important predictive factors for appearance of ST depression,
as well as simultaneous heart ischemia, while the same parameters have border value
as predictive factors for VA.
AD - Military Medical Academy, Clinic of Neurology, Belgrade.
AN - 9612120
AU - Raicević, R.
AU - Jovicic, A.
AU - Tavcioski, D.
AU - Dordević, D.
AU - Krgović, M.
DA - Jan-Feb
DP - NLM
ET - 1998/06/05
IS - 1
J2 - Vojnosanitetski pregled
KW - Acute Disease
Aged
Female
Humans
Male
LA - eng
srp
N1 - Raicević, R
Jovicic, A
Tavcioski, D
Dordević, D
Krgović, M
Journal Article
Serbia
Vojnosanit Pregl. 1998 Jan-Feb;55(1):3-14.
PY - 1998
SN - 0042-8450 (Print)
0042-8450
SP - 3-14
ST - Clinical predictors of cardiac complications in patients with acute ischemic
brain disease
T2 - Vojnosanit Pregl
TI - Clinical predictors of cardiac complications in patients with acute ischemic
brain disease
VL - 55
ID - 2792
ER -
TY - JOUR
AB - To study the relationship between vascular factors and white matter low
attenuation of the brain (WMLA), computer tomography findings of 251 patients were
re-interpreted. Clinical data on patients were collected from the hospital records.
It was possible to obtain sufficient clinical data on 204 patients who were
included in the study. WMLA changes, on computer tomography, were found in 51.5% of
patients. WMLA was most commonly present in patients with vascular (69.8%) and
combined (69.2%) dementia. The occurrence of WMLA did not differ between patients
with Alzheimer's disease (26.7%) and those without dementia (35.9%). Arterial
hypertension, coronary heart disease, or diabetes were not associated with WMLA.
Heart failure and orthostatic hypotension, were found to be more commonly present
in patients with than in those without WMLA (34.0% vs 14.3%, p = 0.0012; 10.0% vs
2.0%, p = 0.036). Both systolic and diastolic low blood pressure values were
associated with WMLA unlike hypertensive blood pressure values. Atrial fibrillation
in electrocardiography was associated with WMLA, while neither left ventricular
hypertrophy nor myocardial infarction was. When several explanatory variables were
adjusted by logistic regression analysis, age, heart failure, and systolic blood
pressure below 130 predicted WMLA. In conclusion, the association between WMLA and
vascular factors with hemodynamic significance suggests that cerebral hypoperfusion
may contribute to the genesis of WMLA.
AD - Department of Geriatric Medicine, University of Turku, Finland.
AN - 8503257
AU - Räihä, I.
AU - Tarvonen, S.
AU - Kurki, T.
AU - Rajala, T.
AU - Sourander, L.
DA - Apr
DO - 10.1111/j.1600-0404.1993.tb05509.x
DP - NLM
ET - 1993/04/01
IS - 4
KW - Adult
Age Factors
Aged
Alzheimer Disease/*diagnostic imaging/etiology/physiopathology
Blood Pressure
Brain/*diagnostic imaging
*Cerebrovascular Circulation
Comorbidity
Dementia, Vascular/*diagnostic imaging/etiology/physiopathology
Electrocardiography
Female
Humans
Hypotension, Orthostatic/epidemiology
Male
Middle Aged
LA - eng
N1 - Räihä, I
Tarvonen, S
Kurki, T
Rajala, T
Sourander, L
Journal Article
Denmark
Acta Neurol Scand. 1993 Apr;87(4):286-9. doi: 10.1111/j.1600-0404.1993.tb05509.x.
PY - 1993
SN - 0001-6314 (Print)
0001-6314
SP - 286-9
ST - Relationship between vascular factors and white matter low attenuation of the
brain
TI - Relationship between vascular factors and white matter low attenuation of the
brain
VL - 87
ID - 2995
ER -
TY - JOUR
AB - STUDY OBJECTIVES: To compare the case mix and outcomes of male and female
patients admitted to intensive care units for a wide range of conditions. DESIGN:
Cross sectional study of prospectively collected data. SETTING: The Intensive Care
National Audit and Research Centre, (ICNARC) Case Mix Programme. PARTICIPANTS: 46
587 admissions to 91 units across England, Wales, and Northern Ireland. MAIN
RESULTS: No gender differences were found in case mix on admission or in mortality
for five conditions (cardiac arrhythmia, chronic obstructive airways disease,
asthma, self poisoning, and seizures). There was some evidence of horizontal and
vertical inequity for female patients with myocardial infarction and with
neurological bleeding. Vertical equity was not achieved for male pneumonia and
ventricular failure patients and for women with primary brain injury. CONCLUSIONS:
This study demonstrated, for the first time, possible inequitable use of intensive
care for patients with certain conditions. This may be secondary to gender bias and
can result in either over-treatment in the favoured group, or under-treatment in
the neglected group. It would therefore be pertinent to re-examine these findings
using other databases, and to further investigate the causative factors, including
gender bias.
AD - Health Services Research Unit, London School of Hygiene and Tropical
Medicine, Keppel Street, London WC1E 7HT, UK. rosalind.raine@lshtm.ac.uk
AN - 12011195
AU - Raine, R.
AU - Goldfrad, C.
AU - Rowan, K.
AU - Black, N.
C2 - PMC1732172
DA - Jun
DO - 10.1136/jech.56.6.418
DP - NLM
ET - 2002/05/16
IS - 6
J2 - Journal of epidemiology and community health
KW - Cross-Sectional Studies
*Diagnosis-Related Groups
Female
Hospital Mortality
Humans
Intensive Care Units/*statistics & numerical data
Male
Patient Admission/*statistics & numerical data
*Prejudice
Prospective Studies
Socioeconomic Factors
United Kingdom/epidemiology
Utilization Review
Women's Health
LA - eng
N1 - 1470-2738
Raine, Rosalind
Goldfrad, C
Rowan, K
Black, N
Comparative Study
Journal Article
J Epidemiol Community Health. 2002 Jun;56(6):418-23. doi: 10.1136/jech.56.6.418.
PY - 2002
SN - 0143-005X (Print)
0143-005x
SP - 418-23
ST - Influence of patient gender on admission to intensive care
T2 - J Epidemiol Community Health
TI - Influence of patient gender on admission to intensive care
VL - 56
ID - 3107
ER -
TY - JOUR
AB - Twenty-five percent of ischemic strokes (IS) are cryptogenic, but it is
estimated that paroxysmal atrial fibrillation (PAF) is the underlying cause in up
to a third of cases. We aimed to investigate the predictive value of speckle
tracking of the left atrium (LA) in diagnosing PAF in IS patients. We
retrospectively studied 186 IS patients with a clinical echocardiographic
examination during sinus rhythm. Outcome was PAF defined by at least one reported
episode of AF following their IS. Conventional echocardiographic measures were
performed. Global longitudinal strain (GLS), LA reservoir-(ε(s)), conduit-(ε(e)),
contraction-strain (ε(a)) and LA dyssynchrony (standard deviation of time-to-peak
ε(s); LA SD-T2P) were obtained by left ventricular and LA speckle tracking. Of 186
patients, 28 (15%) were diagnosed with PAF. PAF-patients did not differ from non-
PAF patients with regards to GLS nor SD-TPS, but atrial strain measures were
significantly impaired at baseline (ε(s) 27 vs. 35%, ε(e) 12 vs. 16%, ε(a) 15 vs.
18%, p < 0.02 for all, for PAF and non-PAF, respectively). However, only ε(s)
remained independently associated with PAF after adjustment for clinical and
echocardiographic parameters (OR 1.13 [1.04; 1.22], p = 0.003, per 1% decrease).
ε(s) also provided the highest area under the receiver operating characteristic
curve among all variables (AUC = 0.74). With a cutoff of 29%, ε(s) had a
specificity of 76% and a negative predictive value of 93%. Atrial reservoir strain
is independently associated with PAF and may be used to improve the diagnosis of
PAF following IS.
AD - Cardiovascular Non-Invasive Imaging Research Laboratory, Department of
Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Niels Andersens
Vej 65, Post 835, 2900, Copenhagen, Denmark. sifmrasmussen@gmail.com.
Cardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology,
Herlev & Gentofte Hospital, University of Copenhagen, Niels Andersens Vej 65, Post
835, 2900, Copenhagen, Denmark.
Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen,
AN - 31028567
AU - Rasmussen, S. M. A.
AU - Olsen, F. J.
AU - Jørgensen, P. G.
AU - Fritz-Hansen, T.
AU - Jespersen, T.
AU - Gislason, G.
DA - Sep
DO - 10.1007/s10554-019-01601-0
DP - NLM
ET - 2019/04/28
IS - 9
KW - Aged
Biomechanical Phenomena
Female
Humans
Male
Middle Aged
Prognosis
Risk Assessment
Risk Factors
Atrial fibrillation
Speckle tracking echocardiography
Strain
Stroke
LA - eng
N1 - 1875-8312
Rasmussen, Sif Maja Aas
Orcid: 0000-0003-2309-4305
Jørgensen, Peter Godsk
Fritz-Hansen, Thomas
Jespersen, Thomas
Gislason, Gunnar
Journal Article
United States
Int J Cardiovasc Imaging. 2019 Sep;35(9):1605-1613. doi: 10.1007/s10554-019-01601-
0. Epub 2019 Apr 26.
PY - 2019
SN - 1569-5794
SP - 1605-1613
ST - Utility of left atrial strain for predicting atrial fibrillation following
ischemic stroke
TI - Utility of left atrial strain for predicting atrial fibrillation following
ischemic stroke
VL - 35
ID - 2315
ER -
TY - JOUR
AB - Four young healthy men (17-25 years old) experienced life-threatening
arrhythmias during physical exertion. All were successfully resuscitated. One died
later. Electrophysiological studies disclosed a lack of normal conduction delay and
abnormal His-Purkinje properties indicating congenital malformation of the
atrioventricular (AV) node in one patient and the rare and potentially dangerous
combination of an accessory AV pathway and intra-atrial conduction delay with
liability to dissimilar rhythms and fibrillation in the atria in another. The
conduction system functioned normally in the other two. One of the latter two
patients had cerebral damage during prolonged resuscitation and experienced
repeated epileptic spells until he died unexpectedly. Autopsy revealed scarring of
unknown origin in the interventricular septum. The other had stress-induced
ventricular ectopy, which gradually diminished and disappeared in a few weeks. The
etiology of the latter two is suggested to be ischemia. It is warranted to point
out the possible danger of maximal physical strain even in young people.
AN - 7180587
AU - Rasmussen, V.
DO - 10.1111/j.0954-6820.1982.tb03227.x
DP - NLM
ET - 1982/01/01
IS - 5
KW - Adolescent
Adult
Electrocardiography
Humans
Male
*Physical Exertion
Resuscitation
*Sports Medicine
LA - eng
N1 - Rasmussen, V
Case Reports
Journal Article
Sweden
Acta Med Scand. 1982;212(5):347-52. doi: 10.1111/j.0954-6820.1982.tb03227.x.
PY - 1982
SN - 0001-6101 (Print)
0001-6101
SP - 347-52
ST - Malignant arrhythmias during strenuous work in four young men
T2 - Acta Med Scand
TI - Malignant arrhythmias during strenuous work in four young men
VL - 212
ID - 2827
ER -
TY - JOUR
AB - OBJECTIVE: The development of new endovascular technologies and techniques
for mechanical thrombectomy in stroke has greatly relied on benchtop simulators.
This paper presents an affordable, versatile, and realistic benchtop simulation
model for stroke. METHODS: A test bed for embolic occlusion of cerebrovascular
arteries and mechanical thrombectomy was developed with 3D-printed and commercially
available cerebrovascular phantoms, a customized hydraulic system to generate
physiological flow rate and pressure, and 2 types of embolus analogs (elastic and
fragment-prone) capable of causing embolic occlusions under physiological flow.
RESULTS: The test bed was highly versatile and allowed realistic, radiation-free
mechanical thrombectomy for stroke due to large-vessel occlusion with rapid
exchange of geometries and phantom types. Of the transparent cerebrovascular
phantoms tested, the 3D-printed phantom was the easiest to manufacture, the glass
model offered the best visibility of the interaction between embolus and
thrombectomy device, and the flexible model most accurately mimicked the
endovascular system during device navigation. None of the phantoms modeled branches
smaller than 1 mm or perforating arteries, and none underwent realistic deformation
or luminal collapse from device manipulation or vacuum. The hydraulic system
created physiological flow rate and pressure leading to iatrogenic embolization
during thrombectomy in all phantoms. Embolus analogs with known fabrication
technique, structure, and tensile strength were introduced and consistently
occluded the middle cerebral artery bifurcation under physiological flow, and their
interaction with the device was accurately visualized. CONCLUSIONS: The test bed
presented in this study is a low-cost, comprehensive, realistic, and versatile
platform that enabled high-quality analysis of embolus-device interaction in
multiple cerebrovascular phantoms and embolus analogs.
AD - Departments of1Neurosurgery and.
2Mechanical Engineering, University of Michigan, Ann Arbor, Michigan.
3Department of Mechanical Engineering, Worcester Polytechnic Institute, Worcester,
Massachusetts; and.
4Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota.
AN - 32244204
AU - Reddy, A. S.
AU - Liu, Y.
AU - Cockrum, J.
AU - Gebrezgiabhier, D.
AU - Davis, E.
AU - Zheng, Y.
AU - Pandey, A. S.
AU - Shih, A. J.
AU - Savastano, L. E.
DA - Apr 3
DO - 10.3171/2020.1.Jns192732
DP - NLM
ET - 2020/04/04
J2 - Journal of neurosurgery
KW - 3D printing
CAD = computer-aided design
CAPTIVE = continuous aspiration prior to intracranial vascular embolectomy
EA = embolus analog
ICA = internal carotid artery
ID = inner diameter
LVO = large-vessel occlusion
MCA = middle cerebral artery
PVC = polyvinyl chloride
RBC = red blood cell
STL = stereolithography
cerebral artery
cerebrovascular simulator
embolus
interventional neurosurgery
large-vessel occlusion
stroke
thrombectomy
vascular disorders
ε = strain
εut = ultimate tensile strain
σ = stress
σut = ultimate tensile stress
LA - eng
N1 - 1933-0693
Reddy, Adithya S
Liu, Yang
Cockrum, Joshua
Gebrezgiabhier, Daniel
Davis, Evan
Zheng, Yihao
Pandey, Aditya S
Shih, Albert J
Savastano, Luis E
Journal Article
United States
J Neurosurg. 2020 Apr 3:1-8. doi: 10.3171/2020.1.JNS192732.
PY - 2020
SN - 0022-3085
SP - 1-8
ST - Construction of a comprehensive endovascular test bed for research and device
development in mechanical thrombectomy in stroke
T2 - J Neurosurg
TI - Construction of a comprehensive endovascular test bed for research and device
development in mechanical thrombectomy in stroke
ID - 3111
ER -
TY - JOUR
AB - PURPOSE OF REVIEW: Atrial fibrillation is the most frequently encountered
tachyarrhythmia requiring therapy. Treatment issues include therapy for any
reversible cause; the identification and treatment of any underlying structural
disorder; control of the ventricular rate, both for symptom reduction and
prevention of tachycardic-induced cardiomyopathy; restoration and maintenance of
sinus rhythm when symptoms persist despite rhythm control; and anticoagulation in
patients with high-risk markers for systemic embolization: age over 65 years,
hypertension, diabetes, ventricular failure, rheumatic valvular disease, and prior
stroke or other embolic event. In such patients, anticoagulation with warfarin is
currently recommended. Warfarin therapy carries significant risks (especially
bleeding), inconveniences (the cost of prothrombin time monitoring, the need for
rigid dietary stability, the concerns of drug and herbal interactions), and other
concerns (the issue of generic formulation substitution). RECENT FINDINGS: Under
development are oral thrombin inhibitors. The first to reach clinical approval will
likely be ximelagatran. In clinical trials to date, ximelagatran has proven to be
equal to or superior to warfarin in the prevention and treatment of
thrombophlebitis. In atrial fibrillation patients, the Stroke Prevention Using Oral
Thrombin Inhibitor in Atrial Fibrillation (SPORTIF) trials completed so far appear
to show a similar or better efficacy for ximelagatran versus warfarin as regards
both prevention of embolic events and lower risks of major bleeding, with no
serious adverse effects except for apparently reversible alterations in liver
function tests in approximately 6% of subjects, all occurring early in therapy to
date. If the remaining SPORTIF trial (SPORTIF V) is confirmatory (results to be
available in late 2003), it is expected that this exciting new product will be
submitted this winter to the Food and Drug Administration for approval. Recent
findings also include the observations in the Atrial Fibrillation Follow-up
Investigation of Rhythm Management (AFFIRM) and Rate Control Versus Electrical
Cardioversion (RACE) trials that anticoagulation should not be discontinued despite
the restoration and maintenance of sinus rhythm. SUMMARY: Oral direct thrombin
inhibitors, such as ximelagatran, appear likely to replace the use of warfarin in
most patients in the near future, because of a better risk-benefit profile.
AD - Department of Clinical Medicine, Columbia University, New York, New York,
USA. jar2@columbia.edu
AN - 14688636
AU - Reiffel, J. A.
DA - Jan
DO - 10.1097/00001573-200401000-00012
DP - NLM
ET - 2003/12/23
IS - 1
Azetidines/administration & dosage/*therapeutic use
Benzylamines
Embolism/etiology/*prevention & control
Fibrinolytic Agents/administration & dosage/*therapeutic use
Humans
Prothrombin Time/economics
Venous Thrombosis/etiology/prevention & control
Warfarin/administration & dosage/*therapeutic use
LA - eng
N1 - Reiffel, James A
Journal Article
Review
United States
Curr Opin Cardiol. 2004 Jan;19(1):58-63. doi: 10.1097/00001573-200401000-00012.
PY - 2004
SN - 0268-4705 (Print)
0268-4705
SP - 58-63
ST - Will direct thrombin inhibitors replace warfarin for preventing embolic
events in atrial fibrillation?
TI - Will direct thrombin inhibitors replace warfarin for preventing embolic
events in atrial fibrillation?
VL - 19
ID - 2627
ER -
TY - JOUR
AB - OBJECTIVES: The purpose of this study was to evaluate the role of congestive
heart failure (CHF) in the association between atrial fibrillation (AF) and sudden
cardiac death (SCD). BACKGROUND: Recent studies have reported the possibility of an
independent association between AF and SCD. We hypothesized that a history of CHF
is a significant confounder of this association. METHODS: In a prospective case-
control analysis from the community (The Oregon-SUDS [Sudden Unexpected Death
Study], 2002 to 2012), SCD cases (n = 652) with clinical records available
(including electrocardiography and/or echocardiography) were compared with age- and
sex-matched control patients with coronary artery disease. The association between
AF and SCD was analyzed using multivariable logistic regression and propensity
score matching. RESULTS: Cases (age 67.3 ± 11.7 years, 65% male) were more likely
than control patients (age 67.2 ± 11.4 years, 65% male) to have a history of AF (p
= 0.0001), myocardial infarction (p = 0.007), CHF (p < 0.0001), stroke (p <
0.0001), and diabetes (p < 0.0001). In multivariate analysis without considering
CHF, AF was a significant predictor of SCD (odds ratio [OR]: 1.6; 95% confidence
interval [CI]: 1.2 to 2.0; p = 0.002). However, in a model that included CHF, the
AF-SCD association was no longer significant (OR: 1.1; 95% CI: 0.8 to 1.5; p =
0.45), whereas CHF was a significant predictor of SCD (OR: 3.1; 95% CI: 2.4 to 4.1;
p < 0.0001). Results on the basis of propensity score matching were consistent.
CONCLUSIONS: Our findings suggest that a history of CHF, including both systolic
and diastolic symptomatic dysfunction, may partially explain the AF-SCD
association.
AD - The Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.
The Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California; Paris
Cardiovascular Research Center, Paris, France.
Department of Pathology, Oregon Health and Science University, Portland, Oregon.
Department of Emergency Medicine, Oregon Health and Science University, Portland,
Oregon.
The Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Electronic address: sumeet.chugh@cshs.org.
AN - 24952687
AU - Reinier, K.
AU - Marijon, E.
AU - Uy-Evanado, A.
AU - Teodorescu, C.
AU - Narayanan, K.
AU - Chugh, H.
AU - Gunson, K.
AU - Jui, J.
AU - Chugh, S. S.
DA - Jun
DO - 10.1016/j.jchf.2013.12.006
DP - NLM
ET - 2014/06/24
IS - 3
J2 - JACC. Heart failure
KW - Aged
Atrial Fibrillation/epidemiology/*etiology
Death, Sudden, Cardiac/epidemiology/*etiology
Diabetic Angiopathies/complications/epidemiology
Female
Heart Failure/*complications/epidemiology
Humans
Male
Myocardial Infarction/complications/epidemiology
Oregon/epidemiology
Prospective Studies
Stroke/complications/epidemiology
Ventricular Dysfunction, Left/complications/epidemiology
arrhythmia
cardiac arrest
diastolic
ejection fraction
LA - eng
N1 - 2213-1787
Reinier, Kyndaron
Marijon, Eloi
Uy-Evanado, Audrey
Teodorescu, Carmen
Narayanan, Kumar
Chugh, Harpriya
Gunson, Karen
Jui, Jonathan
Chugh, Sumeet S
Comparative Study
Journal Article
Observational Study
United States
JACC Heart Fail. 2014 Jun;2(3):221-7. doi: 10.1016/j.jchf.2013.12.006. Epub 2014
Apr 30.
PY - 2014
SN - 2213-1779
SP - 221-7
ST - The association between atrial fibrillation and sudden cardiac death: the
relevance of heart failure
T2 - JACC Heart Fail
TI - The association between atrial fibrillation and sudden cardiac death: the
relevance of heart failure
VL - 2
ID - 2441
ER -
TY - JOUR
AB - One hundred and eighty-four consecutive patients admitted to an Investigative
Stroke Unit with transient ischemic attacks (TIA) and cerebral infarction (stroke)
had 48-hour automated arrhythmia monitoring, 55 patients had additional Holter
monitoring and 127 patients had 2-D echocardiography. One hundred and sixteen
presented with stroke (63%) and 68 patients with TIA (37%). One hundred and twenty-
two were men (66.3%) and 62 were women (33.7%), mean age 63.5 years, range 25-86.
The monitoring identified twelve (6.5%) patients with significant arrhythmias
undetected by history, examination and admission electrocardiogram: six with atrial
fibrillation (AF), four with 2 degrees heart block type Mobitz II and one each with
3 degrees heart block and sick sinus syndrome. Two-D echocardiography showed a
previously unknown potential source for cardiac emboli in 22 patients (17.3%):
segmental ventricular disease in eleven, mitral valve prolapse in seven, left
ventricular thrombus in six, left ventricular aneurysm in three and one each with
mitral valve endocarditis and global myocardial dysfunction. Only the mitral valve
findings were expected on the basis of a previous M-mode echocardiographic study
carried out in our city on healthy elderly volunteers. From the clinical history
and all cardiac investigations, we found 59 patients (32%) with a possible cardiac
source for cerebral emboli. After cerebral angiography, 29 of these 59 patients
also showed a vascular lesion in the appropriate carotid artery and we could not
decide definitely which lesion was responsible for the cerebral embolus. In the
remaining 30 patients (16.4%), the evidence implicated the heart as the most likely
source.(ABSTRACT TRUNCATED AT 250 WORDS)
AN - 4089926
AU - Rem, J. A.
AU - Hachinski, V. C.
AU - Boughner, D. R.
AU - Barnett, H. J.
DA - Nov-Dec
DO - 10.1161/01.str.16.6.950
DP - NLM
ET - 1985/11/01
IS - 6
J2 - Stroke
KW - Adult
Aged
Angiography
Brain/blood supply
Cerebrovascular Disorders/diagnostic imaging/*etiology/physiopathology
Echocardiography
Electrocardiography
Female
Heart Diseases/*complications/diagnosis
Humans
Ischemic Attack, Transient/diagnostic imaging/*etiology/physiopathology
Male
Middle Aged
Risk
LA - eng
N1 - Rem, J A
Hachinski, V C
Boughner, D R
Barnett, H J
Journal Article
United States
Stroke. 1985 Nov-Dec;16(6):950-6. doi: 10.1161/01.str.16.6.950.
PY - 1985
SN - 0039-2499 (Print)
0039-2499
SP - 950-6
ST - Value of cardiac monitoring and echocardiography in TIA and stroke patients
T2 - Stroke
TI - Value of cardiac monitoring and echocardiography in TIA and stroke patients
VL - 16
ID - 2419
ER -
TY - JOUR
AB - The year 2004 was notable, as were the previous years, for advances in
diagnosis, treatment and follow-up of certain congenital cardiac diseases with
studies carried out in the foetus, the child and the adult. Foetal cardiology is in
constant development: the malformations are better detected, left ventricular
function is evaluated by echocardiography, and, consequently, foetal cardiac
failure can be treated. Interventional procedures have started in the foetus with
results that require confirmation. In children and adults, publications of
interventional catheterisation are as numerous as before: percutaneous closure of
atrial septal defects, closure of patent foramen ovale in cases of transient
ischaemic cerebral attacks, closure of congenital or acquired (iatrogenic, post-
infarct or traumatic) ventricular septal defects, percutaneous valve replacement,
maintenance of patent ductus arteriosus. Many other interventional procedures have
been carried out in operated and unoperated congenital heart lesions: angioplasty,
embolisation, valvular stenosis. Adult congenital heart disease may pose problems
of arrhythmia, during pregnancy for example. Cardiac resynchronisation, which is
well developed in adults with cardiac failure, also has indications in congenital
heart disease of children and adults. Pregnancy is possible in women with tetralogy
of Fallot, operated or not, with a maternal risk of left ventricular dysfunction
and progression of pulmonary regurgitation. After a Mustard procedure, pregnancy
may aggravate symptoms and NYHA Class but it is usually well tolerated. Finally,
let's cite one publication which showed, if it was still necessary, that maternal
and foetal risk in pregnancy is high in patients with an Eisenmenger syndrome.
AD - Service des maladies cardiovasculaires infantiles et congénitales, Hôpital
cardiologique, Lille Cedex.
AN - 15714861
AU - Rey, C.
DA - Jan
DP - NLM
ET - 2005/02/18
KW - Cardiac Catheterization
*Heart Defects, Congenital/therapy
Heart Diseases/*congenital/therapy
Humans
LA - fre
N1 - Rey, C
English Abstract
Journal Article
Review
France
Arch Mal Coeur Vaiss. 2005 Jan;98 Spec No 1:33-8.
OP - L'essentiel de 2004 dans les cardiopathies congénitales.
PY - 2005
SN - 0003-9683 (Print)
0003-9683
SP - 33-8
ST - [The best of congenital heart disease in 2004]
TI - [The best of congenital heart disease in 2004]
VL - 98 Spec No 1
ID - 3065
ER -
TY - JOUR
AB - The aim of this study was to evaluate the effect of thrombolytic therapy on
neurologic outcome and mortality in patients after cardiac arrest due to acute ST-
elevation myocardial infarction and to compare this with those in patients treated
with primary percutaneous coronary intervention (PCI). We retrospectively examined
patients after they had ventricular fibrillation cardiac arrests. To assess the
effect of thrombolysis and PCI on outcome, we used odds ratios and their 95%
confidence intervals and logistic regression modeling. Thrombolysis was applied in
101 patients (69%) and PCI in 46 patients (31%). More patients who received
thrombolysis had favorable functional neurologic recovery (cerebral performance
category 1 and 2) and survived to 6 months compared with patients with primary PCI
(P = .38 and P = .13, respectively). In patients with cardiac arrest due to ST-
elevation myocardial infarction, it may be acceptable to use thrombolysis as a
reperfusion strategy. This applies especially in hospitals where immediate PCI is
not available.
AD - Department of Emergency Medicine, Medical University of Vienna, 1090 Vienna,
Austria.
AN - 17543659
AU - Richling, N.
AU - Herkner, H.
AU - Holzer, M.
AU - Riedmueller, E.
AU - Sterz, F.
AU - Schreiber, W.
DA - Jun
DO - 10.1016/j.ajem.2006.10.014
DP - NLM
ET - 2007/06/05
IS - 5
KW - Chi-Square Distribution
Female
Humans
Logistic Models
Male
Middle Aged
Myocardial Reperfusion/*methods
Treatment Outcome
Ventricular Fibrillation/*etiology/*therapy
LA - eng
N1 - 1532-8171
Richling, Nina
Herkner, Harald
Holzer, Michael
Riedmueller, Eva
Sterz, Fritz
Schreiber, Wolfgang
Comparative Study
Journal Article
United States
Am J Emerg Med. 2007 Jun;25(5):545-50. doi: 10.1016/j.ajem.2006.10.014.
PY - 2007
SN - 0735-6757
SP - 545-50
ST - Thrombolytic therapy vs primary percutaneous intervention after ventricular
fibrillation cardiac arrest due to acute ST-segment elevation myocardial infarction
and its effect on outcome
T2 - Am J Emerg Med
TI - Thrombolytic therapy vs primary percutaneous intervention after ventricular
fibrillation cardiac arrest due to acute ST-segment elevation myocardial infarction
and its effect on outcome
VL - 25
ID - 2890
ER -
TY - JOUR
AB - OBJECTIVE: To establish the prevalence of atrial fibrillation (AF) among
acute medical admissions to the Adan Hospital, Kuwait, and to evaluate the clinical
features of the patients. SUBJECTS AND METHODS: Of 2,833 acute medical admissions
to the Adan Hospital from January 1 to May 31, 2003, 120 patients with AF were
included in the study. The patients were divided into paroxysmal or persistent
(PPAF), and chronic atrial fibrillation (CAF). The prevalence of stroke and
clinical features of the CAF patients with and without strokes were studied. All
the patients with AF underwent echocardiography to evaluate left ventricular
ejection fraction (LVEF) and left atrial dimension (LAD). RESULTS: The prevalence
of AF in the study period was 4.24%, of which 68.3% had CAF and 31.7% had PPAF. The
prevalence of heart failure, ischemic heart disease, systemic hypertension, and
diabetes mellitus was 27.5, 55.8, 65.8, and 53.3%, respectively. Patients with CAF
were older and had a higher prevalence of heart failure compared to PPAF patients.
Of the patients with CAF, 26.8% had at least one episode of stroke. The CAF
patients had lower LVEF and larger LAD than PPAF patients. Stroke patients with CAF
had lower LVEF and larger LAD as compared to those without stroke. CONCLUSION:
Atrial fibrillation is a common admission diagnosis in our hospital. Patients with
AF commonly suffer from heart failure, hypertension, diabetes mellitus, and
ischemic heart disease. There was a high prevalence of stroke among CAF patients.
AD - Department of Internal Medicine, Adan Hospital, Ministry of Public Health,
Safat, Kuwait. ridha3@hotmail.com
AN - 15863984
AU - Ridha, M.
AU - Al-Sayed Amin, A.
AU - Saleh, S. A.
AU - Cherian, B.
AU - Al-Kandari, F.
AU - Redha, F.
AU - Jamal, K.
AU - Bitar, Z.
DA - May-Jun
DO - 10.1159/000084628
DP - NLM
ET - 2005/05/03
IS - 3
J2 - Medical principles and practice : international journal of the Kuwait
University, Health Science Centre
KW - Acute Disease
Aged
Atrial Fibrillation/complications/diagnostic imaging/*epidemiology
Chronic Disease
Echocardiography
Female
Hospitalization/*statistics & numerical data
Humans
Kuwait/epidemiology
Male
Middle Aged
Prevalence
Stroke/complications/epidemiology
Stroke Volume
LA - eng
N1 - Ridha, Mustafa
Al-Sayed Amin, Amin
Saleh, Salhamoud A
Cherian, Boby
Al-Kandari, Fawziah
Redha, Faridah
Jamal, Khalid
Bitar, Zouheir
Journal Article
Switzerland
Med Princ Pract. 2005 May-Jun;14(3):136-9. doi: 10.1159/000084628.
PY - 2005
SN - 1011-7571 (Print)
1011-7571
SP - 136-9
ST - The prevalence of atrial fibrillation among acute medical admissions in
Kuwait
T2 - Med Princ Pract
TI - The prevalence of atrial fibrillation among acute medical admissions in
Kuwait
VL - 14
ID - 2620
ER -
TY - JOUR
AB - Atrial fibrillation is the most common cardiac arrhythmia that increases in
prevalence with age. As the general population grows older, general practitioners
will more frequently see this disease in their clinic population. In order to most
effectively treat these patients, physicians need to understand key issues,
including the use of rhythm control versus ventricular rate control and how to
reduce the risk of ischemic stroke. This article will review recent advancements in
the understanding of the pathophysiology, management, stroke risk stratification
and prevention of thromboembolic complications in atrial fibrillation.
AD - Beth Israel Deaconess Medical Center, Department of Cardiology, Boston, MA,
USA.
AN - 21878052
AU - Riley, A. B.
AU - Manning, W. J.
DA - Aug
DO - 10.1586/erc.11.107
DP - NLM
ET - 2011/09/01
IS - 8
KW - Aged
Aged, 80 and over
*Aging
Animals
Atrial Fibrillation/*epidemiology/physiopathology/therapy
Humans
LA - eng
N1 - 1744-8344
Riley, Anne B
Manning, Warren J
Journal Article
Review
England
Expert Rev Cardiovasc Ther. 2011 Aug;9(8):1081-90. doi: 10.1586/erc.11.107.
PY - 2011
SN - 1477-9072
SP - 1081-90
ST - Atrial fibrillation: an epidemic in the elderly
TI - Atrial fibrillation: an epidemic in the elderly
VL - 9
ID - 2544
ER -
TY - JOUR
AB - BACKGROUND: Ablation of the aortic sinus of Valsalva in adults for ectopic
atrial tachycardia (EAT) and ventricular tachycardia (VT)/premature ventricular
complexes (PVCs) has been reported in only a very few patients. Limited data exist
concerning the safety of aortic ablation. OBJECTIVE: The purpose of this study was
to confirm aortic wall and aortic valve integrity after ablation and to evaluate
for potential cerebral embolism due to thrombus formation at aortic wall lesions.
METHODS: From January 2006 to August 2007, 21 patients with EAT (n = 6) or VT/PVCs
(n = 15) originating from the sinus of Valsalva underwent successful ablation. The
aortic wall structure was evaluated using transesophageal echocardiography (TEE)
and magnetic resonance imaging (MRI) the day after ablation and at 6-month follow-
up for all patients. To rule out cerebral embolism due to postablation
thromboembolic events, a cerebral MRI was performed immediately after ablation in
six patients and at 6-month follow-up in all patients. Ablation success was defined
by 24-hour Holter monitoring before hospital discharge and after 6 months. RESULTS:
Aortic wall integrity was confirmed in all patients by TEE and MRI. Cerebral MRI
showed evidence of silent cerebral ischemia in one patient. Aortic valve thickening
was detected in one patient by TEE. CONCLUSION: Ablation in the aortic sinus of
Valsalva is a safe and effective approach for atrial tachycardia or VT/PVCs. The
incidence of silent ischemia needs further evaluation.
AD - Department of Cardiology, Schwarzwald-Baar-Klinikum Villingen-Schwenningen,
Academic Hospital of the University of Freiburg, Germany. arillig5@yahoo.de
AN - 18774100
AU - Rillig, A.
AU - Meyerfeldt, U.
AU - Birkemeyer, R.
AU - Treusch, F.
AU - Kunze, M.
AU - Brasch, M.
AU - Jung, W.
DA - Sep
DO - 10.1016/j.hrthm.2008.06.010
DP - NLM
ET - 2008/09/09
IS - 9
J2 - Heart rhythm
KW - Adult
Aged
Aged, 80 and over
*Catheter Ablation
Female
Humans
Male
Middle Aged
Prospective Studies
Sinus of Valsalva/diagnostic imaging/physiopathology/*surgery
Tachycardia, Supraventricular/diagnostic imaging/physiopathology/*surgery
Tachycardia, Ventricular/diagnostic imaging/physiopathology/*surgery
Ultrasonography
Ventricular Premature Complexes/surgery
LA - eng
N1 - 1556-3871
Rillig, Andreas
Meyerfeldt, Udo
Birkemeyer, Ralf
Treusch, Fabian
Kunze, Markus
Brasch, Mathias
Jung, Werner
Journal Article
United States
Heart Rhythm. 2008 Sep;5(9):1265-72. doi: 10.1016/j.hrthm.2008.06.010. Epub 2008
Jun 12.
PY - 2008
SN - 1547-5271
SP - 1265-72
ST - Catheter ablation within the sinus of Valsalva--a safe and effective approach
for treatment of atrial and ventricular tachycardias
T2 - Heart Rhythm
TI - Catheter ablation within the sinus of Valsalva--a safe and effective approach
for treatment of atrial and ventricular tachycardias
VL - 5
ID - 2440
ER -
TY - JOUR
AB - We studied the neuroprotective effect of magnesium sulphate (MgSO4)
administered before ventricular fibrillation was induced for internal cardioverter
defibrillator threshold testing, and continued during reperfusion. METHODS: With
the intention of increasing serum magnesium (Mg) to >1.2 mmol/L, 15 patients
received 16 mmol of MgSO4, IV, followed by 5 mmol over two hours. Fifteen patients
received placebo. Serum neuron-specific enolase (NSE) was assessed, as well as pre-
and postoperative neurocognitive function. RESULTS: NSE increased in all patients,
reaching a peak at 24 hours. The target Mg level was maintained throughout surgery
in only nine of the Mg patients, and mainly in those with low lean body mass (LBM).
In these patients, increased Mg levels were related to altered NSE release
(P<0.05). NSE increased when serum Mg dropped to <1.2 mmol/L, finally exceeding
levels of inadequately or untreated patients. Neurocognitive function after surgery
was similar between groups. CONCLUSIONS: Insufficient dosing could account for our
results, as NSE release could be inhibited by Mg >1.2 mmol/L. For neuroprotection,
the Mg dosage should be adjusted according to LBM and infusion be extended to >2
hours.
AD - Division of Cardiothoracic and Vascular Anaesthesia and Intensive Care,
Medical University Vienna, Vienna, Austria.
AN - 24184815
AU - Rinösl, H.
AU - Skhirtladze, K.
AU - Felli, A.
AU - Ankersmit, H. J.
AU - Dworschak, M.
DA - Jul-Sep
DO - 10.1684/mrh.2013.0345
DP - NLM
ET - 2013/11/05
IS - 3
J2 - Magnesium research
KW - Body Mass Index
Humans
*Iatrogenic Disease
Magnesium/blood
Magnesium Sulfate/administration & dosage/*pharmacology
Neuroprotective Agents/administration & dosage/*pharmacology
Phosphopyruvate Hydratase/antagonists & inhibitors/blood/metabolism
Nse
global cerebral ischaemia
magnesium sulphate
neurocognitive function
neuroprotection
LA - eng
N1 - 1952-4021
Rinösl, Harald
Skhirtladze, Keso
Felli, Alessia
Ankersmit, Hendrik J
Dworschak, Martin
Journal Article
England
Magnes Res. 2013 Jul-Sep;26(3):109-19. doi: 10.1684/mrh.2013.0345.
PY - 2013
SN - 0953-1424
SP - 109-19
ST - The neuroprotective effect of magnesium sulphate during iatrogenically-
induced ventricular fibrillation
T2 - Magnes Res
TI - The neuroprotective effect of magnesium sulphate during iatrogenically-
induced ventricular fibrillation
VL - 26
ID - 3037
ER -
TY - JOUR
AB - Patients with paroxysmal atrial fibrillation have a risk of thromboembolic
complications probably equivalent to those with permanent atrial fibrillation.
Patients with a previous cerebral infarction, hypertension, age above 65, diabetes,
previous myocardial infarction, reduced left ventricular function, heart failure or
enlarged left atrium with or without a visible thrombus are especially prone to
thromboembolic complications. International guidelines recommend anticoagulation
therapy with warfarin to INR levels between 2.0-3.0 for the majority of patients
with atrial fibrillation. Acetylsalicylic acid provides inferior protection and can
only be recommended for a selected subpopulation of patients. Patients with atrial
fibrillation who convert spontaneously or after medical or electrical treatment,
should have low molecular weight heparin administered prior to conversion and
warfarin for at least four weeks after successful conversion. The rationale for
choosing a treatment strategy in conflict with recommended guidelines should appear
in writing in the patient's file in any individual case.
AD - Hjerte-Lungesenteret, Ullevål Universitetssykehus, 0407 Oslo.
cecilie.risoe@ulleval.no
AN - 15060644
AU - Risøe, C.
AU - Gjesdal, K.
DA - Apr 1
DP - NLM
ET - 2004/04/03
IS - 7
raekke
Atrial Fibrillation/complications/diagnosis/*drug therapy
Humans
Risk Factors
LA - nor
N1 - 0807-7096
Risøe, Cecilie
Gjesdal, Knut
English Abstract
Journal Article
Review
Norway
Tidsskr Nor Laegeforen. 2004 Apr 1;124(7):950-2.
OP - Antikoagulasjonsbehandling ved forbigående atrieflimmer.
PY - 2004
SN - 0029-2001
SP - 950-2
ST - [Anticoagulation therapy in paroxysmal atrial fibrillation]
TI - [Anticoagulation therapy in paroxysmal atrial fibrillation]
VL - 124
ID - 2605
ER -
TY - JOUR
AB - Atrial fibrillation (AF) is a frequent arrhythmia; its prevalence is near 2%
in the general population; in Mexico, more than one-half million people are
affected. AF needs to be considered as a public health problem. Because AF is an
independent risk factor associated with mortality, due to embolic events, heart
failure, or sudden death; early diagnosis is of utmost importance. In unstable
patients with a recent onset of AF, electrical cardioversion should be practiced.
In stable patients, once thromboembolic measures have been taken, it is necessary
to assess whether it is reasonable to administer an antiarrhythmic drug to restore
sinus rhythm or performed electrical cardioversion. For recidivating cases of
paroxysmal and persistent presentation, the most effective strategy is performed
pulmonary vein isolation with either radiofrequency or cryoballoon energy.
Permanent AF is that in which recovery of sinus rhythm is not possible, the
distinguishing feature of this phase is the uncontrollable variability of the
ventricular frequency and could be treated pharmacologically with atrioventricular
(AV) nodal blockers or with a VVIR pacemaker plus AV nodal ablation. The presence
of AF has long been associated with the development of cerebral and systemic
(pulmonary, limb, coronary, renal, and visceral) embolism. The prevention of
embolisms in "valvular" AF should perform with Vitamin K antagonists (VKA). For
patients with AF not associated with mitral stenosis or a mechanical valve
prosthesis, a choice can be made between anticoagulant drugs, VKA, or direct oral
anticoagulants. Antiplatelet agents have the weakest effect in preventing embolism.
AD - Unidad de Arritmias y Estimulación Cardiaca, Centro Médico Nacional Siglo
XXI, Instituto de Seguridad Social y Servicios Sociales de los Trabajadores del
Estado, Ciudad de México.
Servicio de Electrocardiología, Instituto Nacional de Cardiología Ignacio Chávez,
Ciudad de México.
Unidad de Electrofisiología, Hospital General de México, Ciudad de México.
Instituto de Cardiología y Medicina Vascular, Hospital Zambrano Hellion TEC-Salud,
Nuevo Léon.
Servicio de Electrofisiología, Centro Médico Nacional de Occidente-Hospital de
Especialidad, Instituto de Seguridad Social y Servicios Sociales de los
Trabajadores del Estado (ISSSTE), Guadalajara.
Unidad de Arritmias y Estimulación Cardiaca, Centro Médico Sur de los Servicios
Médicos de Salud de Puebla, Puebla, Mexico.
AN - 31996856
AU - Rodríguez-Diez, G.
AU - Márquez, M. F.
AU - Iturralde-Torres, P.
AU - Molina-Fernández de, L. Lg
AU - Pozas-Garza, G.
AU - Cordero-Cabra, A.
AU - Rojel-Martínez, U.
DO - 10.24875/acm.19000323
DP - NLM
ET - 2020/01/31
IS - 1
J2 - Archivos de cardiologia de Mexico
KW - *Ablación con radiofrecuencia
*Crioablación
*Cryoballoon ablation
*Drug treatment
*Fibrilación atrial
*Radiofrequency ablation
*Tratamiento farmacológico
*Tromboprofilaxis
*Tromboprofiláxis
LA - eng
N1 - 1665-1731
Rodríguez-Diez, Gerardo
Márquez, Manlio F
Iturralde-Torres, Pedro
Molina-Fernández de L, Luis G
Pozas-Garza, Gerardo
Cordero-Cabra, Alejandro
Rojel-Martínez, Ulises
Journal Article
Mexico
Arch Cardiol Mex. 2020;90(1):69-76. doi: 10.24875/ACM.19000323.
OP - Posicionamiento conjunto acerca del tratamiento para fibrilación auricular.
PY - 2020
SN - 1665-1731
SP - 69-76
ST - Joint Mexican position document on the treatment of atrial fibrillation
T2 - Arch Cardiol Mex
TI - Joint Mexican position document on the treatment of atrial fibrillation
VL - 90
ID - 3110
ER -
TY - JOUR
AB - Stroke involving some areas of the cerebral hemisphere, such as insula,
amygdala, and lateral hypothalamus, may cause changes in autonomic control of
cardiac function. A 58-year-old woman presented to the emergency department for
acute onset of left facial-brachial-crural hemiparesis and dysarthria. A brain CT
scan showed subacute ischemic lesion with hemorrhagic infarction in right insular-
rolandic cortex. Over the next few days ECG showed severe bradycardia with
elongation of QTc, significative pauses (5 seconds), runs of nonsustained
ventricular tachycardia and torsades de pointes. Drug induced and other several
possible causes of elongation of QT and bradycardia such as hypokalemia, a history
of heart failure, and structural heart disease were ruled out. The case confirms
that insular cortex plays a major role in stroke-induced cardiovascular changes.
AD - Cardiology Department, ASST Nord Milano, Ospedale E. Bassini, Milano, Italy.
Cardiology Department, ASST Nord Milano, Ospedale E. Bassini, Milano, Italy.
Electronic address: alippolis2002@yahoo.it.
AN - 31416760
AU - Romano, I. J.
AU - Lippolis, A.
AU - D'Anna, M.
AU - Gentile, F.
DA - Nov
DO - 10.1016/j.jstrokecerebrovasdis.2019.104308
DP - NLM
ET - 2019/08/17
IS - 11
Bradycardia/etiology/physiopathology
Cerebral Cortex/*blood supply/diagnostic imaging
Female
*Heart Rate
Humans
Long QT Syndrome/diagnosis/*etiology/physiopathology/therapy
Middle Aged
Stroke/*complications/diagnostic imaging/physiopathology/therapy
Tachycardia, Ventricular/etiology/physiopathology
Torsades de Pointes/diagnosis/*etiology/physiopathology/therapy
Treatment Outcome
Ischemic stroke
cardiac arrhythmias
cardiac monitoring, QTc prolongation
right insular stroke
torsades de pointes
LA - eng
N1 - 1532-8511
Romano, Ilaria Jane
Lippolis, Antonio
D'Anna, Margherita
Gentile, Francesco
Case Reports
Journal Article
United States
J Stroke Cerebrovasc Dis. 2019 Nov;28(11):104308. doi:
10.1016/j.jstrokecerebrovasdis.2019.104308. Epub 2019 Aug 12.
PY - 2019
SN - 1052-3057
SP - 104308
ST - Cardiac Arrhythmias and Acute Cerebrovascular Events: A Case of QT
Prolongation and Torsades de Pointes Early After Right Insular Stroke
TI - Cardiac Arrhythmias and Acute Cerebrovascular Events: A Case of QT
Prolongation and Torsades de Pointes Early After Right Insular Stroke
VL - 28
ID - 2301
ER -
TY - JOUR
AB - AIMS: Although studies have suggested good long-term results, arrhythmias,
pulmonary hypertension and left ventricular dysfunction are mentioned as sequelae
long-term after surgical atrial septal defect closure at young age. Most studies
were performed only by questionnaire and in a retrospective manner. The long-term
outcome is very important with regard to future employment and acceptance on
insurance schemes. METHODS AND RESULTS: One hundred and thirty-five consecutive
ASD-patients, operated on in childhood, were studied longitudinally with ECG,
echocardiography, exercise testing and Holter-recording 15 (10-22) and 26 (21-33)
years after surgery. During follow-up no cardiovascular mortality, stroke, heart
failure and no pulmonary hypertension occurred. Symptomatic supraventricular
tachyarrhythmias were present in 6% after 15 years, and an additional 2% occurred
in the last decade; 5% needed pacemaker implantation. No relation was found between
arrhythmias and type of ASD, baseline data, right ventricular dimensions, or age at
operation. Left and right ventricular function and dimension remained unchanged.
Slightly more patients had right atrial dilatation at last follow-up. Exercise
capacity was comparable with the normal Dutch population. CONCLUSIONS: The long-
term outcome after ASD closure at young age shows excellent survival and low
morbidity. The incidence of supraventricular arrhythmias is lower than in natural
history studies of ASD patients and also lower than after surgical correction at
adult age.
AD - Department of Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam,
The Netherlands.
AN - 12573276
AU - Roos-Hesselink, J. W.
AU - Meijboom, F. J.
AU - Spitaels, S. E.
AU - van Domburg, R.
AU - van Rijen, E. H.
AU - Utens, E. M.
AU - Bogers, A. J.
AU - Simoons, M. L.
DA - Jan
DO - 10.1016/s0195-668x(02)00383-4
DP - NLM
ET - 2003/02/08
IS - 2
KW - Adolescent
Adult
Age Factors
Arrhythmias, Cardiac/etiology/mortality
Cardiac Output, Low/etiology/mortality
Child
Child, Preschool
Female
Heart Septal Defects, Atrial/mortality/*surgery
Humans
Incidence
Infant
Infant, Newborn
Male
Medical History Taking
Netherlands/epidemiology
Physical Examination
Postoperative Complications/etiology/mortality
Survival Analysis
Survival Rate
LA - eng
N1 - Roos-Hesselink, J W
Meijboom, F J
Spitaels, S E C
van Domburg, R
van Rijen, E H M
Utens, E M W J
Bogers, A J J C
Simoons, M L
Journal Article
England
Eur Heart J. 2003 Jan;24(2):190-7. doi: 10.1016/s0195-668x(02)00383-4.
PY - 2003
SN - 0195-668X (Print)
0195-668x
SP - 190-7
ST - Excellent survival and low incidence of arrhythmias, stroke and heart failure
long-term after surgical ASD closure at young age. A prospective follow-up study of
21-33 years
T2 - Eur Heart J
TI - Excellent survival and low incidence of arrhythmias, stroke and heart failure
long-term after surgical ASD closure at young age. A prospective follow-up study of
21-33 years
VL - 24
ID - 2379
ER -
TY - JOUR
AB - Pathologic electrocardiogram (ECG) may be present in more than 90% of
patients with subarachnoid haemorrhage. The ECG findings are often transient and
may mimic acute myocardial ischaemia or infarction. These ECG findings may cause
diagnostic problems in patients with subarachnoid haemorrhage who are unconscious
or who have atypical symptoms. Life-threatening arrhythmias are also seen and may
be responsible for sudden deaths in patients with subarachnoid haemorrhage. Other
signs of myocardial injury, such as ventricular wall motion dysfunction, elevated
enzymes, and histological evidence of contraction band necrosis are described. The
myocardial dysfunction known as neurogenic stunned myocardium is reversible if the
patient survives the acute phase, but it may lead to haemodynamic instability and
contribute to the origin of neurogenic pulmonary oedema. The myocardial injury in
subarachnoid haemorrhage may be due to a massive sympathetic stimulation of the
myocardium in response to rapidly increasing intracranial pressure. We illustrate
myocardial injury and dysfunction in a case report where a patient had subarachnoid
haemorrhage with ventricular fibrillation, pulmonary oedema, left ventricular
dysfunction and ST-segment elevation, initially thought to be acute myocardial
infarction.
AD - Medisinsk avdeling, Aust-Agder Sentralsjukehus, Arendal.
AN - 9800493
AU - Rørbakken, G.
AU - Brunvand, H.
AU - Gundersen, T.
AU - Farstad, G.
DA - Sep 20
DP - NLM
ET - 1998/11/04
IS - 22
raekke
KW - Adult
Echocardiography
Electrocardiography
Fatal Outcome
Humans
Male
Pulmonary Edema/diagnosis/*etiology/physiopathology
Subarachnoid Hemorrhage/*complications/diagnosis/physiopathology
Ventricular Dysfunction, Left/diagnosis/*etiology/physiopathology
Ventricular Fibrillation/diagnosis/*etiology/physiopathology
LA - nor
N1 - Rørbakken, G
Brunvand, H
Gundersen, T
Farstad, G
Case Reports
English Abstract
Journal Article
Norway
Tidsskr Nor Laegeforen. 1998 Sep 20;118(22):3430-4.
OP - Kardiopulmonale komplikasjoner ved subaraknoidalblødning.
PY - 1998
SN - 0029-2001 (Print)
0029-2001
SP - 3430-4
ST - [Cardiopulmonary complications in acute subarachnoid hemorrhage]
TI - [Cardiopulmonary complications in acute subarachnoid hemorrhage]
VL - 118
ID - 2919
ER -
TY - JOUR
AB - Carbon monoxide (CO) poisoning affects 50,000 people a year in the United
States. The clinical presentation runs a spectrum, ranging from headache and
dizziness to coma and death, with a mortality rate ranging from 1 to 3%. A
significant number of patients who survive CO poisoning suffer from long-term
neurological and affective sequelae. The neurologic deficits do not necessarily
correlate with blood CO levels but likely result from the pleiotropic effects of CO
on cellular mitochondrial respiration, cellular energy utilization, inflammation,
and free radical generation, especially in the brain and heart. Long-term
neurocognitive deficits occur in 15-40% of patients, whereas approximately one-
third of moderate to severely poisoned patients exhibit cardiac dysfunction,
including arrhythmia, left ventricular systolic dysfunction, and myocardial
infarction. Imaging studies reveal cerebral white matter hyperintensities, with
delayed posthypoxic leukoencephalopathy or diffuse brain atrophy. Management of
these patients requires the identification of accompanying drug ingestions,
especially in the setting of intentional poisoning, fire-related toxic gas
exposures, and inhalational injuries. Conventional therapy is limited to normobaric
and hyperbaric oxygen, with no available antidotal therapy. Although hyperbaric
oxygen significantly reduces the permanent neurological and affective effects of CO
poisoning, a portion of survivors still have substantial morbidity. There has been
some early success in therapies targeting the downstream inflammatory and oxidative
effects of CO poisoning. New methods to directly target the toxic effect of CO,
such as CO scavenging agents, are currently under development.
AD - 1 Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute.
2 Division of Pulmonary, Allergy, and Critical Care Medicine, School of Medicine.
3 Department of Pharmacology and Chemical, and.
4 Center for Metabolism and Mitochondrial Medicine, University of Pittsburgh,
Pennsylvania.
AN - 27753502
AU - Rose, J. J.
AU - Wang, L.
AU - Xu, Q.
AU - McTiernan, C. F.
AU - Shiva, S.
AU - Tejero, J.
AU - Gladwin, M. T.
C2 - PMC5363978
DA - Mar 1
DO - 10.1164/rccm.201606-1275CI
DP - NLM
ET - 2016/10/19
IS - 5
J2 - American journal of respiratory and critical care medicine
KW - Carbon Monoxide Poisoning/diagnosis/*pathology/*therapy
Humans
Hyperbaric Oxygenation
*carbon monoxide
*carbon monoxide poisoning
*mitochondria
LA - eng
N1 - 1535-4970
Rose, Jason J
Orcid: 0000-0003-1347-9148
Wang, Ling
Orcid: 0000-0003-4333-3158
Xu, Qinzi
McTiernan, Charles F
Orcid: 0000-0001-9057-4021
Shiva, Sruti
Tejero, Jesus
Orcid: 0000-0003-3245-9978
Gladwin, Mark T
F32 HL132418/HL/NHLBI NIH HHS/United States
Journal Article
Review
Am J Respir Crit Care Med. 2017 Mar 1;195(5):596-606. doi: 10.1164/rccm.201606-
1275CI.
PY - 2017
SN - 1073-449X (Print)
1073-449x
SP - 596-606
ST - Carbon Monoxide Poisoning: Pathogenesis, Management, and Future Directions of
Therapy
T2 - Am J Respir Crit Care Med
TI - Carbon Monoxide Poisoning: Pathogenesis, Management, and Future Directions of
Therapy
VL - 195
ID - 3078
ER -
TY - JOUR
AB - Sleep is usually associated with a reduction in the frequency of ventricular
arrhythmias. We analyzed 1260 24-hour Holter recordings exhibiting ventricular
ectopy and identified 50 patients who had significant increases in sleep-related
ectopy. This study group was compared to an age, sex, and 24-hour ventricular
ectopic frequency matched control group. There were 21 females and 29 males with a
mean age of 64 years in each group. During sleep, the study patients had more
frequency of ventricular ectopy per hour than did controls (mean +/- SEM; 143.2 +/-
30.7 vs 62.9 +/- 16.3; p less than 0.005). The study group had fewer daytime
ventricular premature beats per hour than did the control patients (45.2 +/- 13.6
vs 67.7 +/- 13.8; p less than 0.05). The study patients also exhibited a
significant sleep-related increase in complexity of ventricular arrhythmias (chi 2
= 22.1; p less than 0.001) and the control group a decrease (chi 2 = 19.1; p less
0.001). Nocturnal heart rates were slower than daytime rates in both the study
(69.4 +/- 14.5 vs 79.2 +/- 12.2 bpm; p less than 0.005) and control groups (75.5
+/- 15.8 vs 82.6 +/- 16.4 bpm; p less than 0.005), without significant differences
between the two groups. No significant differences in clinical and ECG
characteristics of the study and control groups were found regarding presence or
type of organic heart disease, pulmonary disease, hypertension, medication use,
intraventricular conduction delay, abnormal Q waves, ventricular hypertrophy, or QT
prolongation. Neurologic abnormalities (60% vs 28%; chi 2 = 9.38 p less than
0.005), in particular cerebrovascular disease (30% vs 14%; chi 2 = 7.56; p less
than 0.01), were significantly more common in the study group. We have identified a
subgroup of individuals with ventricular ectopy who increase the frequency and
complexity of premature ventricular beats during sleep. The higher prevalence of
neurologic disease in these individuals suggests a neurologic or neurohumoral
mediation of these arrhythmias.
AN - 6613817
AU - Rosenberg, M. J.
AU - Uretz, E.
AU - Denes, P.
DA - Oct
DO - 10.1016/0002-8703(83)90091-1
DP - NLM
ET - 1983/10/01
IS - 4 Pt 1
KW - Aged
Arrhythmias, Cardiac/*physiopathology
Female
Heart/*physiopathology
Heart Rate
Humans
Male
Middle Aged
Sleep/*physiology
LA - eng
N1 - Rosenberg, M J
Uretz, E
Denes, P
Journal Article
United States
Am Heart J. 1983 Oct;106(4 Pt 1):703-9. doi: 10.1016/0002-8703(83)90091-1.
PY - 1983
SN - 0002-8703 (Print)
0002-8703
SP - 703-9
ST - Sleep and ventricular arrhythmias
T2 - Am Heart J
TI - Sleep and ventricular arrhythmias
VL - 106
ID - 2865
ER -
TY - JOUR
AB - Problems of arrhythmogenic sudden death (ASD) in athletes have been re-
assessed on the clinicopathological plane, encompassing the emerging, unsolved,
question of so-called idiopathic ventricular tachycardia, and its debated
diagnostics versus arrhythmogenic right ventricular dysplasia-cardiopathy.
Ischemic-infarction ASD from coronary artery pathology in young athletes has been
seen to present with atherosclerotic "soft" subintimal plaques, rich in newly
formed smooth myocytes, often attended by adventitial mast cell, as suspect
microscopic markers of spasm, relevant to reperfusion; these features can be found
also in precociously intramural arteries, responsible for ASD. Rare congenital
abnormalities of the coronary ostia occasionally underlie ASD, together with the
acquired aneurysmic coronaritis of chronic Kawasaki disease. Ischemic ASD can also
be due to coronary arteriolopathy attending hypertrophic cardiomyopathy, a not
uncommon disease in athletes, to be carefully discriminated from training heart
hypertrophy. Young South-American sportsmen with Chagas' chronic cardiopathy seem
to be at particular risk of ASD. Minor, but specific arrhythmogenic cardiac
malformations such as accessory AV pathways have been detected in athletes
succumbing to otherwise unexplained ASD, undergone careful post-mortem
investigation. The need of more attentive and extended histopathologic control
emerges from the hitherto ignored cardiac neuropathological substrates of
reflexogenic ASD, which is cogent to problems of ASD in competing athletes. The
thorough examination of the cardiac vascular centers in the brain stem, and of the
peripheral cardiac innervation, at either abutments of the arc of dive- and/or
Bezold-Jarisch cardioinhibitory-vasodepressor reflex, made it possible to suggest
novel clinicopathological explanations in controversial cases of athletes' ASD,
safeguarding from grave leval misjudgements due to sport's forensic medical
mistakes.
AD - Department of Pathology, University of Milan, Italy.
AN - 7500631
AU - Rossi, L.
DA - Jun
DP - NLM
ET - 1995/06/01
IS - 2
J2 - The Journal of sports medicine and physical fitness
Brain Stem/pathology
Cardiomyopathies/complications
Coronary Artery Disease/complications
Coronary Vasospasm/complications
Heart Conduction System/pathology
Heart Defects, Congenital/complications
Humans
Neural Pathways/pathology
Risk Factors
*Sports
Sports Medicine
Tachycardia, Ventricular/etiology
Ventricular Dysfunction, Right/etiology
LA - eng
N1 - Rossi, L
Journal Article
Review
Italy
J Sports Med Phys Fitness. 1995 Jun;35(2):79-86.
PY - 1995
SN - 0022-4707 (Print)
0022-4707
SP - 79-86
ST - Structural and non-structural disease underlying high-risk cardiac
arrhythmias relevant to sports medicine
T2 - J Sports Med Phys Fitness
TI - Structural and non-structural disease underlying high-risk cardiac
arrhythmias relevant to sports medicine
VL - 35
ID - 2909
ER -
TY - JOUR
AB - BACKGROUND: Atrial fibrillation (AF) increases the risk of atrioembolic
stroke. However, the role of anticoagulation therapy (OAT) in preventing
cerebrovascular accidents (CVA) after intracardiac echocardiography-guided
pulmonary vein antrum isolation (ICE-PVAI) is still unclear. In the present study,
we evaluated the incidence of CVA following the interruption of OAT 3 months after
ICE-PVAI. METHODS: Between September 2002 and March 2004, 85 consecutive patients
(72 men, mean age 62 +/- 7 years) underwent ICE-PVAI for symptomatic drug-
refractory AF. Heart disease was present in 61 patients (72%) (left ventricular
ejection fraction = 58 +/- 6%, LA diameter 44 +/- 6 mm). Eighty-five consecutive
patients who underwent electrical cardioversion (EC) for AF, matched for age, sex
and heart disease, served as a control group. After 3 months, OAT was stopped
unless one of the following conditions was observed: (i) AF-recurrence; (ii) severe
pulmonary vein stenosis; (iii) non-good atrial contractility on transesophageal
echocardiography; or (iv) other indications for OAT. RESULTS: In the study group,
OAT was stopped after 3 months in 77 patients (90%) and no CVA occurred during the
remaining follow-up (15 +/- 7 months). In the control group, 1 month after EC, OAT
was stopped by the referring physician in 29 patients (34%). A stroke occurred in
five patients (6%) (P = 0.09; mean P = 0.059) during follow-up. In two of these
(2%), the stroke was fatal. CONCLUSIONS: Stopping OAT 3 months after ICE-PVAI seems
to be safe in patients without AF recurrences after the first 3 months following
ablation. Further randomized-controlled studies are needed to confirm these
preliminary data.
AD - Department of Cardiology, Umberto I Hospital, Mestre-Venice, Italy.
a.rossillo@tiscali.it
AN - 18268419
AU - Rossillo, A.
AU - Bonso, A.
AU - Themistoclakis, S.
AU - Riccio, G.
AU - Madalosso, M.
AU - Corrado, A.
AU - De Piccoli, B.
AU - Raviele, A.
DA - Jan
DO - 10.2459/JCM.0b013e32801462d4
DP - NLM
ET - 2008/02/13
IS - 1
KW - Anticoagulants/*administration & dosage/therapeutic use
Atrial Fibrillation/complications/diagnostic imaging/*therapy
Female
Follow-Up Studies
Heparin/*administration & dosage/therapeutic use
Humans
Incidence
Male
Middle Aged
Risk Factors
Stroke/epidemiology/etiology/prevention & control
Treatment Outcome
LA - eng
N1 - Rossillo, Antonio
Bonso, Aldo
Themistoclakis, Sakis
Riccio, Giuseppe
Madalosso, Michela
Corrado, Andrea
De Piccoli, Bruno
Raviele, Antonio
Comparative Study
Journal Article
United States
J Cardiovasc Med (Hagerstown). 2008 Jan;9(1):51-5. doi:
10.2459/JCM.0b013e32801462d4.
PY - 2008
SN - 1558-2027 (Print)
1558-2027
SP - 51-5
ST - Role of anticoagulation therapy after pulmonary vein antrum isolation for
atrial fibrillation treatment
TI - Role of anticoagulation therapy after pulmonary vein antrum isolation for
atrial fibrillation treatment
VL - 9
ID - 2699
ER -
TY - JOUR
AB - BACKGROUND: Diffuse or unresectable subaortic stenosis (SAS) necessitates an
aggressive surgical approach for the elimination of left ventricular outflow tract
obstruction. In this article we report our experience with the modified Konno-
Rastan procedure, with inherent preservation of the native aortic valve and
annulus, in the treatment of diffuse or unresectable SAS. METHODS: Sixteen children
(age range, 21 months to 18 years) underwent the modified Konno-Rastan procedure
through either a transventricular (n = 12) or a transatrial approach (n = 4) to the
conal septum. Indications for operation were recurrent SAS (n = 3), hypertrophic
obstructive cardiomyopathy (n = 3), tunnel stenosis (n = 2), SAS related to a canal
(n = 3), and SAS after ventricular septal defect closure (n = 5). Eleven patients
had undergone previous procedures and 5 underwent the modified Konno-Rastan
procedure as their primary operation. RESULTS: The mean preoperative left
ventricular outflow tract gradient of 50 +/- 17 mm Hg was reduced to 3 +/- 7 mm Hg
(p < 0.001) after surgical repair. Postoperative complications included sternal
infection (n = 1), heart block (n = 2), mediastinal bleeding (n = 1), and renal and
cerebral ischemia (n = 1). There was 1 late postoperative death caused by pneumonia
2 years after operation (6.2% mortality rate). The mean follow-up period was 62 +/-
39 months and all patients had complete relief of preoperative symptoms and were in
New York Heart Association class I. One patient underwent a successful redo
modified Konno-Rastan procedure 7 years after the first operation for residual left
ventricular outflow tract obstruction immediately below the aortic valve. One
patient is awaiting reoperation for aortic incompetence unrelated to conal
enlargement 1.5 years after the first procedure. CONCLUSIONS: The modified Konno-
Rastan procedure represents an excellent therapy for diffuse or unresectable SAS in
patients with a normal aortic valve. In addition, it produces excellent results in
a limited number of patients with hypertrophic obstructive cardiomyopathy, in whom
the Morrow procedure traditionally has been performed. Although it usually is
performed through a transventricular approach, the modified Konno-Rastan procedure
also can be performed through a transatrial approach; this is particularly useful
in patients who have had previous ventricular septal defect closure associated with
SAS occurring proximal to the prosthetic patch.
AD - Department of Thoracic-Cardiovascular Surgery, Loyola University Stritch
School of Medicine, Maywood, Illinois 60153, USA.
AN - 9594868
AU - Roughneen, P. T.
AU - DeLeon, S. Y.
AU - Cetta, F.
AU - Vitullo, D. A.
AU - Bell, T. J.
AU - Fisher, E. A.
AU - Blakeman, B. P.
AU - Bakhos, M.
DA - May
DO - 10.1016/s0003-4975(97)01421-5
DP - NLM
ET - 1998/05/22
IS - 5
KW - Adolescent
Aortic Valve/surgery
Aortic Valve Insufficiency/surgery
Cardiomyopathy, Hypertrophic/surgery
Child
Child, Preschool
Follow-Up Studies
Heart Block/etiology
Heart Septal Defects, Ventricular/surgery
Heart Septum/surgery
Humans
Infant
Ischemia/etiology
Kidney/blood supply
Pneumonia/etiology
Polytetrafluoroethylene
Postoperative Hemorrhage/etiology
Prostheses and Implants
Recurrence
Reoperation
Stroke Volume
Surgical Wound Infection/etiology
Survival Rate
Ventricular Outflow Obstruction/surgery
LA - eng
N1 - Roughneen, P T
DeLeon, S Y
Cetta, F
Vitullo, D A
Bell, T J
Fisher, E A
Blakeman, B P
Bakhos, M
Journal Article
Netherlands
Ann Thorac Surg. 1998 May;65(5):1368-75; discussion 1375-6. doi: 10.1016/s0003-
4975(97)01421-5.
PY - 1998
SN - 0003-4975 (Print)
0003-4975
SP - 1368-75; discussion 1375-6
ST - Modified Konno-Rastan procedure for subaortic stenosis: indications,
operative techniques, and results
TI - Modified Konno-Rastan procedure for subaortic stenosis: indications,
operative techniques, and results
VL - 65
ID - 3047
ER -
TY - JOUR
AB - BACKGROUND: Stroke is a devastating complication in patients with prosthetic
valves, but characterization of its late occurrence from a large cohort is lacking.
METHODS: Three thousand one hundred eighty-nine adult patients who underwent a
total of 3,576 operations for left-heart valve replacement were managed with
contemporary anticoagulation guidelines and prospectively followed in a dedicated
clinic. Total follow-up was 20,096 patient years. Bootstrapped survival analysis
was used to determine the impact of patient and valve related factors on the
incidence of stroke. RESULTS: Most strokes were embolic. Linearized embolic stroke
rates were 1.3% +/- 0.2% per year for aortic bioprostheses, 1.4% +/- 0.2% per year
for aortic mechanical valves, 1.3% +/- 0.3% per year for mitral bioprostheses, and
2.3% +/- 0.4% per year for mitral mechanical valves (p = 0.002, vs other implant
types). Age more than 75 years, female gender, and smoking were independent risk
factors after aortic and mitral valve replacement. Atrial fibrillation, coronary
disease, and tilting-disc mechanical prostheses were independent predictors of
embolic stroke after aortic valve replacement. Preoperative left ventricular (LV)
dysfunction was an independent risk factor in patients with mitral prostheses.
Primary operative indication, diabetes, redo status, or the presence of two
prosthetic valves were not associated with an increased hazard. The addition of
acetyl salicylic or dipyridamole to warfarin anticoagulation did not significantly
lower embolic stroke risk in patients with mechanical prostheses. CONCLUSIONS:
Approximately 20% of patients with valve prostheses have an embolic stroke by 15
years after valve replacement. Some risk factors such as the avoidance of smoking,
mitral mechanical prostheses, aortic tilting-disc valves, and proceeding to mitral
surgery before LV dysfunction occurs are potentially modifiable.
AD - Department of Epidemiology and Community Medicine, University of Ottawa,
Ottawa, Ontario, Canada. mruel@ottawaheart.ca
AN - 15223407
AU - Ruel, M.
AU - Masters, R. G.
AU - Rubens, F. D.
AU - Bédard, P. J.
AU - Pipe, A. L.
AU - Goldstein, W. G.
AU - Hendry, P. J.
AU - Mesana, T. G.
DA - Jul
DO - 10.1016/j.athoracsur.2003.12.058
DP - NLM
ET - 2004/06/30
IS - 1
KW - Adult
Aged
Aged, 80 and over
Aspirin/administration & dosage/therapeutic use
Cerebral Hemorrhage/epidemiology/etiology/prevention & control
Comorbidity
Dipyridamole/administration & dosage/therapeutic use
Female
Follow-Up Studies
Heart Valve Prosthesis Implantation/*statistics & numerical data
Humans
Incidence
Intracranial Embolism/epidemiology/etiology/prevention & control
Life Tables
Male
Middle Aged
Mitral Valve/*surgery
Postoperative Complications/*epidemiology/etiology/prevention & control
Prospective Studies
Risk Factors
Stroke/*epidemiology/etiology/prevention & control
LA - eng
N1 - 1552-6259
Ruel, Marc
Masters, Roy G
Rubens, Fraser D
Bédard, Pierre J
Pipe, Andrew L
Goldstein, William G
Hendry, Paul J
Mesana, Thierry G
Journal Article
Netherlands
Ann Thorac Surg. 2004 Jul;78(1):77-83; discussion 83-4. doi:
10.1016/j.athoracsur.2003.12.058.
PY - 2004
SN - 0003-4975
SP - 77-83; discussion 83-4
ST - Late incidence and determinants of stroke after aortic and mitral valve
replacement
TI - Late incidence and determinants of stroke after aortic and mitral valve
replacement
VL - 78
ID - 2860
ER -
TY - JOUR
AB - Ventricular arrhythmias detected in the late-hospital phase of myocardial
infarction have been identified as a risk factor for sudden death, being their
prognostic value independent of ventricular function. However, relations between
both factors are not clarified. In order to study hypothetic associations between
ventricular arrhythmias and some clinical, hemodynamic and angiographic variables,
60 patients (52 males, 8 females) underwent 24-hour Holter recordings and cardiac
catheterization with left ventricular and coronary angiographies, 3-5 weeks after
hospital admission. Past history data, acute phase complications and hemodynamic
and angiographic results were compared between patients with and without
significant ventricular arrhythmias during Holter monitoring (10 or more PVC's/hour
and/or repetitive forms). No significant differences were found between both groups
neither in mean age nor in the incidence of previous angina or infarction, cerebral
ischemia, diabetes, lipid disorders or subjective feeling of being under
psychological stress. Prior history of arterial hypertension was, however,
significantly more frequent in patients with ventricular arrhythmias (53.3% vs
17.8%; p = 0.0183). No differences were observed in the localization of the infarct
or in the complications during the acute phase (CPK peak, Killip's score, angina
after 24 hours of evolution, intraventricular or A-V conduction disorders and
supraventricular and ventricular arrhythmias). Among hemodynamic data, only left
ventricular and aortic systolic pressures were different in both groups, being
significantly higher in patients with ventricular arrhythmias. There were not
differences in left ventricular segmentary contraction and in number of coronary
vessels involved. To conclude, significant ventricular arrhythmias were recorded in
25% of patients.(ABSTRACT TRUNCATED AT 250 WORDS)
AD - Servicio de Cardiología, Hospital Clínico Universitario, Valencia.
AN - 2392609
AU - Ruiz Granell, R.
AU - Querchfeld, A.
AU - García Civera, R.
AU - Insa Pérez, L. D.
AU - Sanchis Fores, J.
AU - Martínez-Curt, S. M.
AU - Morell Cabedo, S.
AU - Sanjuán Máñez, R.
AU - López Merino, V.
DA - May
DP - NLM
ET - 1990/05/01
IS - 5
KW - Adult
Arrhythmias, Cardiac/*etiology/physiopathology
Female
Humans
Male
Middle Aged
Myocardial Infarction/*complications/pathology
Prospective Studies
Risk Factors
LA - spa
N1 - Ruiz Granell, R
Querchfeld, A
García Civera, R
Insa Pérez, L D
Sanchis Fores, J
Martínez-Curt, S M
Morell Cabedo, S
Sanjuán Máñez, R
López Merino, V
English Abstract
Journal Article
Spain
Rev Esp Cardiol. 1990 May;43(5):293-9.
OP - Sustrato anatomofuncional de las arritmias de alto riesgo tras el infarto de
miocardio.
PY - 1990
SN - 0300-8932 (Print)
0300-8932
SP - 293-9
ST - [Anatomo-functional substrate of high risk arrhythmia after myocardial
infarct]
TI - [Anatomo-functional substrate of high risk arrhythmia after myocardial
infarct]
VL - 43
ID - 2726
ER -
TY - JOUR
AB - BACKGROUND: We investigated whether left ventricular filling pressure is
associated with arterial occlusion in patients with ischemic stroke related to
atrial fibrillation (AF). METHODS: Ninety-nine patients with AF-related stroke were
included. Left ventricular filling pressure was assessed by E (early mitral inflow
velocity)/e' (early diastolic velocity of the mitral valve annulus velocity) ratio
based on tissue Doppler echocardiography. Arterial occlusion was evaluated by
computed tomography or magnetic resonance angiography. In addition, the presence of
a hyperdense middle cerebral artery sign (HMCAS) on noncontrast brain computed
tomography, a marker of acute thrombus burden, was assessed. Multiple logistic
regression was used to evaluate the association of E/e' with arterial occlusion and
the HMCAS. RESULTS: The mean age was 73.2 (±10.2), and 56% were men. Thirty-six
(36.4%) patients had arterial occlusion on imaging. E/e' ratios were independently
associated with arterial occlusion with an odds ratio of 1.24 (per 1 increase, 95%
confidence interval 1.11-1.38). The receiver operating characteristics curve
demonstrated that E/e' ratios have an excellent discriminatory capacity in
predicting arterial occlusion with an area under the curve of .77 (P < .001). In
addition, E/e' ratios were higher in patients with HMCAS than in those without
(19.1 versus 14.0, P < .001). CONCLUSION: E/e' ratios were associated with arterial
occlusion in AF-related stroke and may play a role in identifying patients at high
risk of severe stroke.
AD - Department of Neurology, Dongguk University Ilsan Hospital, Goyang, South
Korea. Electronic address: wisunryu@gmail.com.
Department of Neurology, Inha University Hospital, Incheon, South Korea.
Department of Neurology, Dongguk University Ilsan Hospital, Goyang, South Korea.
Departments of Radiology and Experimental Diagnostic Imaging, University of Texas
M.D. Anderson Cancer Center, Houston, Texas.
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical
School, Boston, Massachusetts.
Department of Neurology, Dongguk University Ilsan Hospital, Goyang, South Korea.
Electronic address: kdongeog@duih.org.
AN - 29310958
AU - Ryu, W. S.
AU - Bae, E. K.
AU - Park, S. H.
AU - Jeong, S. W.
AU - Schellingerhout, D.
AU - Nahrendorf, M.
AU - Kim, D. E.
DA - May
DP - NLM
ET - 2018/01/10
IS - 5
KW - Aged
Aged, 80 and over
Atrial Fibrillation/*complications/diagnostic imaging/physiopathology
Cerebral Angiography/methods
Cerebral Arterial Diseases/diagnostic imaging/*etiology/physiopathology
Computed Tomography Angiography
Female
Humans
Logistic Models
Magnetic Resonance Angiography
Male
Middle Aged
Mitral Valve/diagnostic imaging/physiopathology
Odds Ratio
Prospective Studies
Risk Factors
Stroke/diagnostic imaging/*etiology/physiopathology
*Ventricular Pressure
Heart failure
atrial fibrillation
cerebral infarction
LA - eng
N1 - 1532-8511
Ryu, Wi-Sun
Bae, Eun-Kee
Park, Soo-Hyun
Jeong, Sang-Wuk
Schellingerhout, Dawid
Nahrendorf, Matthias
Kim, Dong-Eog
Journal Article
United States
J Stroke Cerebrovasc Dis. 2018 May;27(5):1275-1282. doi:
10.1016/j.jstrokecerebrovasdis.2017.12.009. Epub 2018 Jan 5.
PY - 2018
SN - 1052-3057
SP - 1275-1282
ST - Increased Left Ventricular Filling Pressure and Arterial Occlusion in Stroke
Related to Atrial Fibrillation
TI - Increased Left Ventricular Filling Pressure and Arterial Occlusion in Stroke
Related to Atrial Fibrillation
VL - 27
ID - 2313
ER -
TY - JOUR
AB - Herein we report the case of a patient who suffered from global cerebral
ischemia due to pump stoppage of Jarvik2000 Left ventricular assist device (LVAD)
for unknown reason and fatal ventricular arrhythmia at home. Cardiopulmonary
resuscitation was started by paramedics 6-7 min after the patient fell down. The
patient was transferred to our hospital after the restoration of the LVAD function
by exchanging external cables. Mild therapeutic hypothermia was induced and body
temperature was kept at 33 °C for 24 h. After rewarming, the patient recovered his
consciousness without any neurological deficit.
AD - Department of Cardiovascular Surgery, Fukui Cardiovascular Center, 2-228,
Shimpo, Fukui, 910-0833, Japan. shunsaito0404@gmail.com.
AN - 30826998
AU - Saito, S.
AU - Toda, K.
AU - Miyagawa, S.
AU - Yoshikawa, Y.
AU - Hata, H.
AU - Yoshioka, D.
AU - Kainuma, S.
AU - Yoshida, S.
AU - Sawa, Y.
DA - Sep
DO - 10.1007/s10047-019-01099-2
DP - NLM
ET - 2019/03/04
IS - 3
J2 - Journal of artificial organs : the official journal of the Japanese Society
for Artificial Organs
KW - Adult
Brain Ischemia/*etiology/*therapy
Humans
Male
Treatment Outcome
Device malfunction
Jarvik 2000
Left ventricular assist device
Therapeutic hypothermia
LA - eng
N1 - 1619-0904
Saito, Shunsuke
Toda, Koichi
Miyagawa, Shigeru
Yoshikawa, Yasushi
Hata, Hiroki
Yoshioka, Daisuke
Kainuma, Satoshi
Yoshida, Shohei
Sawa, Yoshiki
Case Reports
Journal Article
Japan
J Artif Organs. 2019 Sep;22(3):246-248. doi: 10.1007/s10047-019-01099-2. Epub 2019
Mar 2.
PY - 2019
SN - 1434-7229
SP - 246-248
ST - Therapeutic hypothermia after global cerebral ischemia due to left
ventricular assist device malfunction
T2 - J Artif Organs
TI - Therapeutic hypothermia after global cerebral ischemia due to left
ventricular assist device malfunction
VL - 22
ID - 3057
ER -
TY - JOUR
AB - BACKGROUND: There is a need to stratify patients who may develop heart
failure because of the current "heart failure pandemic". We hypothesized that
noninvasive assessment of diastolic electromechanical coupling by
electrocardiography and Doppler echocardiography may be clinically useful for risk
stratification of hypertensive patients who may develop heart failure. METHODS: We
measured the time from the peak to end of the T wave (TpTe) as an
electrophysiological parameter, and peak early diastolic mitral flow (E) and
lateral annular (e') velocities as mechanical parameters in 109 patients with
hypertension. Relationships between these parameters and their association with the
prognosis were evaluated. RESULTS: The e' was inversely correlated with TpTe (p <
0.001) and QTc (p < 0.014), whereas E/e' was positively correlated with TpTe (p <
0.001) and QTc (p < 0.001). The TpTe predicted patients with E/e' > 12. There were
24 cardiovascular events during follow-up (57 ± 20 months), and Kaplan-Meier
analysis showed that outcome was worse (p = 0.003) in patients with higher E/e'
than lower E/e'; however, there was no difference between patients with longer TpTe
(≧72 ms) and shorter TpTe (< 72 ms). CONCLUSION: The correlation of TpTe with e'
and E/e' in hypertensive patients suggests that these parameters reflect diastolic
ventricular electromechanical coupling. The E/e' predicted outcome, and an elevated
E/e' should be suspected when TpTe is prolonged (> 72 ms). Noninvasive evaluation
of diastolic electromechanical coupling is clinically useful in patients with
hypertension for predicting their outcome.
AD - Department of Cardiovascular Medicine, Tokushima University Hospital,
Tokushima, Japan.
Department of Cardiovascular Medicine, Tokushima University Hospital, Tokushima,
Japan. yamadah@tokushima-u.ac.jp.
Department of Community Medicine for Cardiology, Tokushima University Graduate
School of Biomedical Sciences, 2-50-1 Kuramoto, Tokushima, Japan.
yamadah@tokushima-u.ac.jp.
Department of Chronomedicine, Tokushima University, Tokushima, Japan.
AN - 30756346
AU - Saito, Y.
AU - Yamada, H.
AU - Kusunose, K.
AU - Saito, K.
AU - Sata, M.
DA - Dec
DO - 10.1007/s12574-019-00421-4
DP - NLM
ET - 2019/02/14
IS - 4
J2 - Journal of echocardiography
KW - Aged
Cerebral Infarction/epidemiology
Diastole
Female
Follow-Up Studies
Heart/*diagnostic imaging/physiopathology
Humans
Hypertension/*diagnostic imaging/physiopathology
Male
Middle Aged
*Diastolic electromechanical coupling
*E/e′
*Hypertension
*Tpeak–Tend interval
LA - eng
N1 - 1880-344x
Saito, Yuko
Yamada, Hirotsugu
Orcid: 0000-0003-3741-5560
Kusunose, Kenya
Saito, Ken
Sata, Masataka
Journal Article
Japan
J Echocardiogr. 2019 Dec;17(4):206-212. doi: 10.1007/s12574-019-00421-4. Epub 2019
Feb 12.
PY - 2019
SN - 1349-0222
SP - 206-212
ST - Noninvasive assessment of left-ventricular diastolic electromechanical
coupling in hypertensive heart disease
T2 - J Echocardiogr
TI - Noninvasive assessment of left-ventricular diastolic electromechanical
coupling in hypertensive heart disease
VL - 17
ID - 2437
ER -
TY - JOUR
AB - BACKGROUND: Subjects with frequent ventricular premature complexes (VPC) and
no apparent heart disease make a heterogenic group with regard to prognosis. Some
biomarkers have recently proved useful in risk stratification in different heart
diseases. We examined prognostic impact of NT-Pro-brain natriuretic peptide (NT-Pro
BNP), and C-reactive protein (CRP) in relation to frequent VPC in subjects with no
apparent heart disease. METHODS: Six hundred seventy-eight healthy subjects between
55 and 75 years of age with no history of cardiovascular disease were included in
the study. All were tested with fasting laboratory testing and 48-hour ambulatory
ECG monitoring. Frequent VPC was defined as VPC > or =30/hour. RESULTS: In 56
subjects (8%) with frequent VPC the prognosis was much poorer compared to those
without frequent VPC (Hazard ratio and 95% CI: 2.3;1.2-4.4, P = 0.01), after
adjustment for conventional risk factors. In subjects with frequent VPC increased
levels of CRP (above 2.5 microg/mL) was the only factor among the tested
biomarkers, which was associated with a poor prognosis. Taking subjects without
frequent VPC as reference, the hazard ratio and 95% CI for subjects with frequent
VPC and increased CRP was 3.6;1.8-7.1, P = 0.0004, and for those with frequent VPC
and normal CRP 0.8;0.2-3.5, P = 0.83, after correction for conventional risk
factors. CONCLUSIONS: Among middle-aged and elderly subjects with no apparent heart
disease and frequent VPCs, a CRP value > or =2.5 microg/mL is associated with a
significantly higher risk of death and acute myocardial infarction. These subjects
deserve primary prevention measures and further work up for structural heart
disease.
AD - Department of Cardiology, Copenhagen University Hospital of Bispebjerg,
Bispebjerg Bakke, Copenhagen NV, Denmark. ahs@dadlnet.dk
AN - 17100670
AU - Sajadieh, A.
AU - Nielsen, O. W.
AU - Rasmussen, V.
AU - Ole Hein, H.
AU - Hansen, J. F.
DA - Nov
DO - 10.1111/j.1540-8159.2006.00518.x
DP - NLM
ET - 2006/11/15
IS - 11
KW - Aged
Biomarkers/blood
C-Reactive Protein/*analysis
Comorbidity
Denmark/epidemiology
Electrocardiography, Ambulatory/statistics & numerical data
Female
Heart Diseases/blood/diagnosis/mortality
Humans
Incidence
Male
Middle Aged
Myocardial Infarction/*blood/diagnosis/*mortality
Prognosis
Risk Factors
Survival Analysis
Survival Rate
Ventricular Premature Complexes/*blood/diagnosis/*mortality
LA - eng
N1 - Sajadieh, Ahmad
Nielsen, Olav Wendelboe
Rasmussen, Verner
Ole Hein, Hans
Hansen, Jørgen Fischer
Journal Article
United States
Pacing Clin Electrophysiol. 2006 Nov;29(11):1188-94. doi: 10.1111/j.1540-
8159.2006.00518.x.
PY - 2006
SN - 0147-8389 (Print)
0147-8389
SP - 1188-94
ST - Increased ventricular ectopic activity in relation to C-reactive protein, and
NT-pro-brain natriuretic peptide in subjects with no apparent heart disease
TI - Increased ventricular ectopic activity in relation to C-reactive protein, and
NT-pro-brain natriuretic peptide in subjects with no apparent heart disease
VL - 29
ID - 2400
ER -
TY - JOUR
AB - BACKGROUND: Many Kawasaki disease (KD) patients have reached adulthood in
Japan. The current status of adult patients who have giant coronary aneurysms with
KD is not well understood. METHODS: Medical records of 48 KD patients (33 males and
15 females) with giant coronary aneurysms (maximum coronary artery internal
diameter >8 mm) aged 20 years or over were retrospectively reviewed. RESULTS: The
age of the patients at the diagnosis of KD ranged from 0.3 to 12.8 years (median
2.9 years) and the age of the patients in this review ranged from 20.0 to 33.1
years (median 25.2 years). During the follow-up period, the maximum coronary artery
internal diameter ranged from 8.2 to 30.0 mm (median 10 mm). Giant coronary
aneurysms progressed to coronary artery stenosis and/or complete occlusion in 34
(74%) of 46 patients. Coronary artery bypass graft surgery was performed in 9 (19%)
of 48 patients. Myocardial infarction occurred in 14 (31%) of 45 patients. Other
complications or problems occurred in 5 patients with angina pectoris, low left
ventricular ejection fraction, ventricular tachycardia, hemorrhagic cerebral
infarction, or thyroid carcinoma respectively. In the patients followed up, 4
dropped out. In addition, 1 patient succeeded in pregnancy and delivered a baby.
CONCLUSIONS: Close attention should be paid to ventricular tachycardia in adult KD
patients with giant coronary aneurysms, especially for those who have low left
ventricular ejection fraction. To reduce the number of dropped out patients, it is
important that the patients should be referred to a new doctor when they change
their place of residence.
AD - Department of Pediatrics, Jichi Medical University, Tochigi, 329-0498, Japan.
ksamada@jichi.ac.jp
AN - 20143209
AU - Samada, K.
AU - Shiraishi, H.
AU - Sato, A.
AU - Momoi, M. Y.
DA - Feb
DO - 10.1007/s12519-010-0004-7
DP - NLM
ET - 2010/02/10
IS - 1
J2 - World journal of pediatrics : WJP
KW - Adult
Angina Pectoris/epidemiology
Brain Infarction/epidemiology
Coronary Aneurysm/*epidemiology
Coronary Artery Bypass/statistics & numerical data
Coronary Occlusion/epidemiology
Coronary Stenosis/epidemiology
Female
Follow-Up Studies
Humans
Japan/epidemiology
Male
Mucocutaneous Lymph Node Syndrome/*epidemiology
Pregnancy
Stroke Volume
Thyroid Neoplasms/epidemiology
LA - eng
N1 - 1867-0687
Samada, Kazunori
Shiraishi, Hirohiko
Sato, Asami
Momoi, Mariko Y
Journal Article
Switzerland
World J Pediatr. 2010 Feb;6(1):38-42. doi: 10.1007/s12519-010-0004-7. Epub 2010 Feb
9.
PY - 2010
SP - 38-42
ST - Grown-up Kawasaki disease patients who have giant coronary aneurysms
T2 - World J Pediatr
TI - Grown-up Kawasaki disease patients who have giant coronary aneurysms
VL - 6
ID - 2884
ER -
TY - JOUR
AB - Extracranial carotid arterial obstructive disease has been the entity most
commonly associated with transient cerebrovascular insufficiency. A nonobstructive,
frequently overlooked cause of cerebral ischemia is cardiac dysrhythmia. We have
explored this by observations of experimental animals and of man. Blood flow and
pressure in the carotid arteries of dogs were shown to be decreased by mechnically
induced premature ventricular contractions. The significance of the cardiogenic
contribution to altered cerebrovascular perfusion was studied by ocular and
brachial plethysmography in 210 patients suspected by history of having carotid
arterial insufficiency. Of the 210 patients, 62 demonstrated abnormal ocular
plethysmographic recordings, and of those, nine had dysrhythmias associated with
significant deficits of ocular perfusion. Five patients whose recordings were
technically suitable for publication are presented to demonstrate the bizarre
ocular plethysmographic recordings seen during the dysrhythmic cycle.
AN - 938224
AU - Sand, B. J.
AU - Rose, H. B.
AU - Barker, W. F.
DA - Jul
DO - 10.1001/archsurg.1976.01360250063013
DP - NLM
ET - 1976/07/01
IS - 7
J2 - Archives of surgery (Chicago, Ill. : 1960)
KW - Adult
Aged
Animals
Brachial Artery
Brain/blood supply
Dogs
Electrocardiography
Eye/blood supply
Female
*Hemodynamics
Humans
Ischemic Attack, Transient/diagnosis/*etiology
Male
Middle Aged
Plethysmography
LA - eng
N1 - Sand, B J
Rose, H B
Barker, W F
Journal Article
United States
Arch Surg. 1976 Jul;111(7):787-91. doi: 10.1001/archsurg.1976.01360250063013.
PY - 1976
SN - 0004-0010 (Print)
0004-0010
SP - 787-91
ST - Effect of cardiac dysrhythmia on cerebral perfusion
T2 - Arch Surg
TI - Effect of cardiac dysrhythmia on cerebral perfusion
VL - 111
ID - 2727
ER -
TY - JOUR
AB - BACKGROUND AND PURPOSE: Limited data exists regarding the relationship
between left ventricular systolic dysfunction (LVSD) and heart failure (HF)
symptoms and embolic risk among patients with atrial fibrillation. METHODS:
Participants in the Atrial Fibrillation Clopidogrel Trial With Irbesartan for
Prevention of Vascular Events (ACTIVE) trials with HF, but not randomized to oral
anticoagulation, were categorized as having preserved versus reduced ejection
fraction. If reduced, LVSD was classified as mild, moderate, or severe. Symptoms
were quantified using New York Heart Association class.The primary outcome was a
composite of stroke, transient ischemic attack, and systemic embolism. RESULTS:
There were 3487 antiplatelet-treated patients with HF at baseline. Of these
patients, 969 (46.8%) had HF with preserved ejection fraction and 1103 (53.2%) had
HF with reduced ejection fraction. During 3.6 years of mean follow-up, first
occurrence of stroke, transient ischemic attack, or systemic embolism occurred in
386 patients.The strongest independent predictors of embolic events were age ≥75
years (hazard ratio 2.55; confidence interval, 1.85-3.53), prior stroke or
transient ischemic attack (hazard ratio 2.07; 95% confidence interval, 1.65-2.60),
and female sex (hazard ratio 1.37; confidence interval, 1.11-1.69). However,
ejection fraction <0.50, degree of LVSD, and New York Heart Association class did
not predict embolic events. Patients with HF with preserved ejection fraction
exhibited similar risk of embolic events as those with HR with reduced ejection
fraction: 4.3% versus 4.4% per 100 person-years (hazard ration 1.01; 95% confidence
interval, 0.78-1.31). Risk of embolic events was similar across categories of LVSD
(P for trend =0.96) and New York Heart Association class (P for trend =0.57).
CONCLUSION: Among HF patients in ACTIVE, neither the presence of LVSD or degree of
symptom severity influenced risk of embolic events.
AD - From the Division of Cardiology, Mazankowski Alberta Heart Institute,
University of Alberta, Edmonton, Canada (R.K.S.); Division of Cardiac
Electrophysiology, J.W. Goethe University, Frankfurt, Germany (S.H.H.); Division of
Cardiology, Brigham and Women's Hospital, Harvard University, Boston, MA (M.A.P.);
Division of Neurology (R.G.H.), Division of Cardiology (S.Y., S.J.C., J.S.H.),
Population Health Research Institute (F.Y.), McMaster University, Hamilton, ON,
Canada; The Canadian VIGOUR Center, Edmonton, Alberta, Canada (F.A.M.); and
Division of General Internal Medicine, University of Alberta, Edmonton, Canada
(F.A.M.). rsandhu2@ualberta.ca.
From the Division of Cardiology, Mazankowski Alberta Heart Institute, University of
Alberta, Edmonton, Canada (R.K.S.); Division of Cardiac Electrophysiology, J.W.
Goethe University, Frankfurt, Germany (S.H.H.); Division of Cardiology, Brigham and
Women's Hospital, Harvard University, Boston, MA (M.A.P.); Division of Neurology
(R.G.H.), Division of Cardiology (S.Y., S.J.C., J.S.H.), Population Health Research
Institute (F.Y.), McMaster University, Hamilton, ON, Canada; The Canadian VIGOUR
Center, Edmonton, Alberta, Canada (F.A.M.); and Division of General Internal
Medicine, University of Alberta, Edmonton, Canada (F.A.M.).
AN - 25628308
AU - Sandhu, R. K.
AU - Hohnloser, S. H.
AU - Pfeffer, M. A.
AU - Yuan, F.
AU - Hart, R. G.
AU - Yusuf, S.
AU - McAlister, F. A.
AU - Healey, J. S.
DA - Mar
DO - 10.1161/strokeaha.114.007140
DP - NLM
ET - 2015/01/30
IS - 3
J2 - Stroke
Aged
Atrial Fibrillation/drug therapy/*physiopathology
Biphenyl Compounds/therapeutic use
Clopidogrel
Female
Heart Failure/drug therapy/*physiopathology
Humans
Irbesartan
Ischemic Attack, Transient/drug therapy/physiopathology
Male
Middle Aged
Stroke/diagnosis
Tetrazoles/therapeutic use
Ticlopidine/analogs & derivatives/therapeutic use
Treatment Outcome
Ventricular Dysfunction, Left/*diagnosis/physiopathology
atrial fibrillation
heart failure
stroke
LA - eng
N1 - 1524-4628
Sandhu, Roopinder K
Hohnloser, Stefan H
Pfeffer, Marc A
Yuan, Fei
Hart, Robert G
Yusuf, Salim
Connolly, Stuart J
McAlister, Finlay A
Healey, Jeff S
Journal Article
Multicenter Study
United States
Stroke. 2015 Mar;46(3):667-72. doi: 10.1161/STROKEAHA.114.007140. Epub 2015 Jan 27.
PY - 2015
SN - 0039-2499
SP - 667-72
ST - Relationship between degree of left ventricular dysfunction, symptom status,
and risk of embolic events in patients with atrial fibrillation and heart failure
T2 - Stroke
TI - Relationship between degree of left ventricular dysfunction, symptom status,
and risk of embolic events in patients with atrial fibrillation and heart failure
VL - 46
ID - 2444
ER -
TY - JOUR
AB - A 69-year-old man was admitted to our hospital with cardiopulmonary arrest.
Percutaneous cardio-pulmonary support (PCPS) using the right femoral artery and
vein was initiated, because ventricular fibrillation continued. Although we
succeeded in defibrillation after percutaneous coronary intervention (PCI), a chest
radiograph indicated a pneumothorax in the right lung and a pulmonic contusion in
the left lung caused by cardiopulmonary resuscitation. Two days after PCI, partial
pressure of arterial oxygen (PaO2) from the right radial artery suddenly decreased,
and his cardiac function showed improvement on an echocardiogram. To avoid
additional brain damage, we converted the treatment to veno-venous extracorporeal
membrane oxygenation by changing the blood returning site of PCPS from the right
femoral artery to the right jugular vein. Thereafter, the patient's PaO2 level
gradually improved.
AD - Internal Medicine, Self-Defense Forces Fuji Hospital, Japan.
AN - 27432096
AU - Sato, A.
AU - Isoda, K.
AU - Gatate, Y.
AU - Akita, K.
AU - Daida, H.
DP - NLM
ET - 2016/07/20
IS - 14
KW - Aged
Cardiopulmonary Resuscitation/adverse effects/methods
Echocardiography
*Extracorporeal Membrane Oxygenation
Humans
Lung Injury/*complications
Male
Percutaneous Coronary Intervention/adverse effects/methods
LA - eng
N1 - 1349-7235
Sato, Atsushi
Isoda, Kikuo
Gatate, Yodo
Akita, Koji
Daida, Hiroyuki
Case Reports
Journal Article
Japan
Jul 15.
PY - 2016
SN - 0918-2918
SP - 1877-9
ST - Successful Management of a Patient with Refractory Ventricular Fibrillation
(VF) due to Acute Myocardial Infarction (AMI) and Lung Injury by Transition from
Percutaneous Cardiopulmonary Support (PCPS) to Veno-Venous Extracorporeal Membrane
Oxygenation (ECMO)
T2 - Intern Med
TI - Successful Management of a Patient with Refractory Ventricular Fibrillation
(VF) due to Acute Myocardial Infarction (AMI) and Lung Injury by Transition from
Percutaneous Cardiopulmonary Support (PCPS) to Veno-Venous Extracorporeal Membrane
Oxygenation (ECMO)
VL - 55
ID - 2934
ER -
TY - JOUR
AB - This study was done to clarify the relationship between asymptomatic brain
infarcts and risk factors for atherogenis. A total of 312 patients (151 men and 161
women) who had no neurologic deficits were enrolled. Their ages ranged from 41 to
83 years (mean age 63 years). The patients were divided into two groups: 158
patients without asymptomatic brain infarct and 154 patients with at least one
asymptomatic brain infarct of at least 5 mm as diagnosed by magnetic resonance
imaging. The patients with asymptomatic brain infarct were more likely than those
without asymptomatic brain infarct to be 65 years old or older, and to have
essential hypertension, diabetes mellitus, or atrial fibrillation. Among patients
with hypertension the frequency of left ventricular hypertrophy or hypertensive
ocular findings (Scheie's class H2) was significantly higher in those with
asymptomatic brain infarct than in those without asymptomatic brain infarct. These
results indicate that aging, essential hypertension (especially with left
ventricular hypertrophy or hypertensive ocular findings), diabetes mellitus, and
atrial fibrillation are associated with asymptomatic brain infarct.
AD - First Department of Internal Medicine, Nara Medical University, Kashihara.
AN - 9267150
AU - Sawai, N.
AU - Yamano, S.
AU - Minami, S.
AU - Yamamoto, Y.
AU - Akai, M.
AU - Nomura, K.
AU - Dohi, K.
DA - May
DP - NLM
ET - 1997/05/01
IS - 5
KW - Adult
Aged
Aged, 80 and over
Aging/*physiology
Cerebral Infarction/*etiology/physiopathology
Female
Humans
Male
Middle Aged
Risk Factors
LA - jpn
N1 - Sawai, N
Yamano, S
Minami, S
Yamamoto, Y
Akai, M
Nomura, K
Dohi, K
English Abstract
Journal Article
Japan
Nihon Ronen Igakkai Zasshi. 1997 May;34(5):389-94. doi: 10.3143/geriatrics.34.389.
PY - 1997
SN - 0300-9173 (Print)
0300-9173
SP - 389-94
ST - [Effects of atherogenic risk factors on asymptomatic brain infarct]
TI - [Effects of atherogenic risk factors on asymptomatic brain infarct]
VL - 34
ID - 2749
ER -
TY - JOUR
AB - BACKGROUND: Current guidelines for epicardial catheter ablation for
ventricular tachycardia (VT) advocate that epicardial access is avoided in
anticoagulated patients and should be performed prior to heparinisation. Recent
studies have shown that epicardial access may be safe in heparinised patients.
However, no data exist for patients on oral anticoagulants. We investigated the
safety of obtaining epicardial access on uninterrupted warfarin. METHODS: A
prospective registry of patients undergoing epicardial VT ablation over two years
was analysed. Consecutive patients in whom epicardial access was attempted were
included. All patients were heparinised prior to epicardial access with a target
activated clotting time (ACT) of 300-350s. Patients who had procedures performed on
uninterrupted warfarin (in addition to heparin) were compared to those not taking
an oral anticoagulant. RESULTS: 46 patients were included of which 13 were taking
warfarin. There was no significant difference in clinical and procedural
characteristics (except INR and AF) between the two groups. Epicardial access was
achieved in all patients. There were no deaths and no patients required surgery. A
higher proportion of patients in the warfarin group had a drop in haemoglobin of
>2g/dL compared to the no-warfarin group (38.5% versus 27.3%, p=0.74) and delayed
pericardial drain removal (7.8% versus 3.03%, p=0.47). There was no difference in
overall procedural complication rate. No patients required warfarin reversal or
blood transfusion. CONCLUSION: Epicardial access can be achieved safely and
effectively in patients' anticoagulated with warfarin and heparinised with
therapeutic ACT. This may be an attractive option for patients with a high stroke
risk.
AD - Cardiology Department, St Bartholomew's Hospital, London, United Kingdom.
Electronic address: sawhneyvin@googlemail.com.
Cardiology Department, St Bartholomew's Hospital, London, United Kingdom.
Cardiology Department, St Bartholomew's Hospital, London, United Kingdom.
Electronic address: rossjhunter@gmail.com.
AN - 27454616
AU - Sawhney, V.
AU - Breitenstein, A.
AU - Ullah, W.
AU - Finlay, M.
AU - Sporton, S.
AU - Earley, M. J.
AU - Chow, A. W.
AU - Dhinoja, M.
AU - Lambiase, P.
AU - Schilling, R. J.
AU - Hunter, R. J.
DA - Nov 1
DO - 10.1016/j.ijcard.2016.07.113
DP - NLM
ET - 2016/07/28
KW - Aged
Anticoagulants/administration & dosage/adverse effects
*Catheter Ablation/adverse effects/methods
Female
*Heparin/administration & dosage/adverse effects
Humans
Intraoperative Complications/*prevention & control
Male
Middle Aged
Pericardium/*surgery
Perioperative Care/methods/statistics & numerical data
*Stroke/etiology/prevention & control
*Tachycardia, Ventricular/diagnosis/drug therapy/surgery
United Kingdom
*Warfarin/administration & dosage/adverse effects
Epicardial access
Heparin
Uninterrupted warfarin
VT ablation
LA - eng
N1 - 1874-1754
Sawhney, V
Breitenstein, A
Ullah, W
Finlay, M
Sporton, S
Earley, M J
Chow, A W
Dhinoja, M
Lambiase, P
Schilling, R J
Hunter, R J
Journal Article
Netherlands
Int J Cardiol. 2016 Nov 1;222:57-61. doi: 10.1016/j.ijcard.2016.07.113. Epub 2016
Jul 10.
PY - 2016
SN - 0167-5273
SP - 57-61
ST - Epicardial catheter ablation for ventricular tachycardia on uninterrupted
warfarin: A safe approach for those with a strong indication for peri-procedural
anticoagulation?
T2 - Int J Cardiol
TI - Epicardial catheter ablation for ventricular tachycardia on uninterrupted
warfarin: A safe approach for those with a strong indication for peri-procedural
anticoagulation?
VL - 222
ID - 2655
ER -
TY - JOUR
AB - There are 2 fundamental approaches to managing patients with recurrent atrial
fibrillation (AF): to restore and maintain sinus rhythm with cardioversion and/or
antiarrhythmic drugs, or to control the ventricular rate only. Over the past few
years, there have been several important prospective clinical trials comparing rate
control with rhythm control in patients with recurrent AF. The Pharmacological
Intervention in Atrial Fibrillation (PIAF) trial was the first prospective
randomized study to test the hypothesis of equivalency between the 2 management
strategies for AF. The trial demonstrated that rate control was not inferior to
rhythm control with respect to symptoms, quality of life, or number of
hospitalizations in patients with persistent AF. The Strategies of Treatment in
Atrial Fibrillation (STAF) trial was a pilot study that enrolled approximately 200
patients with AF who were randomized to either ventricular rate control or
cardioversion and maintenance of sinus rhythm. The results showed that over a 1-
year period there was little difference in outcome in terms of morbidity or
symptoms. In the Atrial Fibrillation Follow-up Investigation of Rhythm Management
(AFFIRM) trial, patients with AF and risk factors for stroke were randomized to
either rhythm control or rate control, with both groups receiving anticoagulation
with warfarin. There was no difference in the composite end point of death,
disabling stroke or anoxic encephalopathy, major bleeding, or cardiac arrest
between the 2 arms. In addition, no major differences were noted in functional
status or quality of life. The Rate Control Versus Electrical Cardioversion (RACE)
trial also reached a similar conclusion. Thus, rate control is an acceptable
primary strategy for management of patients with recurrent AF.
AD - University of Florida, Gainesville, Florida 32610, USA.
AN - 12670639
AU - Saxonhouse, S. J.
AU - Curtis, A. B.
DA - Mar 20
DO - 10.1016/s0002-9149(02)03376-3
DP - NLM
ET - 2003/04/03
IS - 6a
Anti-Arrhythmia Agents/adverse effects/pharmacology/*therapeutic use
Atrial Fibrillation/complications/*drug therapy/*physiopathology
Diltiazem/therapeutic use
Heart Conduction System/*drug effects/*physiopathology
Humans
Multicenter Studies as Topic
Recurrence
Therapeutic Equivalency
LA - eng
N1 - Saxonhouse, Sherry J
Curtis, Anne B
Journal Article
Review
United States
Am J Cardiol. 2003 Mar 20;91(6A):27D-32D. doi: 10.1016/s0002-9149(02)03376-3.
PY - 2003
SN - 0002-9149 (Print)
0002-9149
SP - 27d-32d
ST - Risks and benefits of rate control versus maintenance of sinus rhythm
T2 - Am J Cardiol
TI - Risks and benefits of rate control versus maintenance of sinus rhythm
VL - 91
ID - 2460
ER -
TY - JOUR
AB - This case report describes the electrophysiological findings of a 62-year-old
patient with chronic Chagas' disease and two distinct morphologies of sustained
ventricular tachycardia that involved a mitral isthmus. Multiple RF applications
were necessary to obtain a bidirectional conduction block in the mitral isthmus
that was related to the interruption of both tachycardias. After the procedure, the
patient presented massive cerebral infarction that progressed to coma and death.
Autopsy showed acute and old lesions at the mitral isthmus and recent mitral
annulus thrombosis.
AD - Heart Institute (InCor) University of São Paulo, São Paulo, Brazil.
arrscan;vaincor.usp.br
AN - 11990669
AU - Scanavacca, M.
AU - Sosa, E.
AU - d'Avila, A.
AU - De Lourdes Higuchi, M.
DA - Mar
DO - 10.1046/j.1460-9592.2002.00368.x
DP - NLM
ET - 2002/05/07
IS - 3
KW - Catheter Ablation/*methods
Chagas Cardiomyopathy/*complications
Chronic Disease
Electrocardiography
Fatal Outcome
Female
Heart Conduction System/physiopathology/*surgery
Humans
Middle Aged
Mitral Valve/pathology/*physiopathology
Recurrence
Tachycardia, Ventricular/etiology/physiopathology/*surgery
LA - eng
N1 - Scanavacca, Mauricio
Sosa, Eduardo
d'Avila, André
De Lourdes Higuchi, Maria
Case Reports
Journal Article
United States
Pacing Clin Electrophysiol. 2002 Mar;25(3):368-71. doi: 10.1046/j.1460-
9592.2002.00368.x.
PY - 2002
SN - 0147-8389 (Print)
0147-8389
SP - 368-71
ST - Radiofrequency ablation of sustained ventricular tachycardia related to the
mitral isthmus in Chagas' disease
TI - Radiofrequency ablation of sustained ventricular tachycardia related to the
mitral isthmus in Chagas' disease
VL - 25
ID - 2835
ER -
TY - JOUR
AB - BACKGROUND: Chronic atrial fibrillation unassociated with rheumatic valvular
heart disease (NRAF) considerably increases the risk of thromboembolism. Recent
studies have provided new evidence concerning the risk-benefit ratio of
anticoagulant therapies in patients with AF. OBJECTIVE: To evaluate the incidence
of primary end points (ischemic stroke, systemic embolism, bleeding complications
to oral anticoagulant or antiplatelet therapy) and secondary end points (death,
TIA) in patients with NRAF. METHODS AND RESULTS: Between November 1992 and June
1993, 694 patients with chronic NRAF were enrolled in the Trieste Area Study on
Nonrheumatic Atrial Fibrillation (TASAF), an ongoing prospective community study
with a follow-up period of 2 years. The preliminary results of the enrolled study
population show: an elevated mean age (71 +/- 9 years), the prevalence of males
(383/694), high prevalence of overt or previous heart failure (23%), of mitral
regurgitation confirmed at echocardiography (30%) and of previous myocardial
infarction (11%). Many of the enrolled patients had a history of hypertension
(58%). With regard to the etiology of the underlying heart disease, the following
should be emphasized: a high incidence of cardiac hypertrophy (with or without
history of hypertension) (28%) and of degenerative cardiopathy (20%);
unclassifiable cardiopathy (14%); and lone AF (13%). Echocardiographic findings:
left ventricular dysfunction (17%); mitral annular calcification (27%); and good
mean left ventricular function (EF 0.50 +/- 0.15). Retrospectively there were 96
clinically documented embolic events in 78 subjects while in 34 patients there were
38 episodes suspected for embolism or TIA. Nine patients suffered 1 recurrence of
embolism; three patients suffered 2 recurrences; one patient had 3 recurrences; and
4 patients had one suspected recurrence of TIA. In 35 cases the embolic events
clustered around the time of the onset of the arrhythmia. In the other 99 subjects
the embolic complication appeared after the onset of AF: range 1-266 months. The
group of patients with true embolic events in comparison with patients without
embolism or with suspected embolism or TIA had same variables predictive of
thromboembolic complications: arrhythmia duration (p = 0.09) and previous
myocardial infarction (p = 0.03); in contrast mitral annular calcification (p =
0.06), history of hypertension (p = 0.09) and cardiac hypertrophy (with or without
hypertension) (p = 0.07) demonstrated only a slight trend of statistical
significance. Comparing the clinical characteristics and echocardiographic findings
of patients without embolism with those of patients with tru embolism, or suspected
embolism, or TIA the variables predictive of thromboembolic events were: arrhythmia
duration (p = 0.007), history of hypertension (p = 0.01), cardiac hypertrophy (with
or without hypertension (p = 0.02) and mitral annular calcification (p = 0.01), at
the same time, age showed only a trend of statistical significance (p = 0.06).
Among the 616 patients without a history of embolism only 3% were treated with oral
anticoagulant agents and 28% with antiplatelet therapy, while among the 78 subjects
with documented embolism only 28% were receiving anticoagulant therapy and 58% were
receiving antiplatelet agents. CONCLUSIONS: NRAF is an important risk factor for
thromboembolism. Some clinical characteristics and echocardiographic findings
increase the risk. Physicians still hesitate to use oral anticoagulants and
antiplatelet agents in their patients for the prevention of embolic complications.
AD - Centro Cardiovascolare, Ospedale Maggiore, Trieste.
AN - 7642022
AU - Scardi, S.
AU - Mazzone, C.
AU - Goldstein, D.
AU - Pandullo, C.
AU - Poletti, A.
AU - Humar, F.
AU - Pivotti, F.
AU - De Santis, C.
DA - Feb
DP - NLM
ET - 1995/02/01
IS - 2
KW - Aged
Atrial Fibrillation/complications/*epidemiology
Chronic Disease
Female
Humans
Incidence
Italy/epidemiology
Male
Middle Aged
Prospective Studies
Rheumatic Heart Disease
Risk Factors
Thromboembolism/epidemiology/etiology
Urban Population/*statistics & numerical data
LA - ita
N1 - Scardi, S
Mazzone, C
Goldstein, D
Pandullo, C
Poletti, A
Humar, F
Pivotti, F
De Santis, C
Comparative Study
English Abstract
Journal Article
Italy
G Ital Cardiol. 1995 Feb;25(2):173-82.
OP - SFAAT: studio della fibrillazione atriale cronica non reumatica nell'area
triestina. Risultati dell'arruolamento.
PY - 1995
SN - 0046-5968 (Print)
0046-5968
SP - 173-82
ST - [SFAAT: the study of nonrheumatic chronic atrial fibrillation in the Trieste
area. Results of an enrollment study]
T2 - G Ital Cardiol
TI - [SFAAT: the study of nonrheumatic chronic atrial fibrillation in the Trieste
area. Results of an enrollment study]
VL - 25
ID - 2761
ER -
TY - JOUR
AB - BACKGROUND: Non-rheumatic atrial fibrillation (NRAF) is a very common
arrhythmia but its role in the prognosis and cardiovascular mortality is
controversial. In particular, cause and predictors of death are not completely
known. METHODS: We analyzed the cause of death and the possible predictors of
cardiovascular mortality in 664 outpatients (mean age 72 +/- 9 years old) enrolled
in the "Trieste Area Study on Non-Rheumatic Atrial Fibrillation" (TASAF), a
prospective community study, after a follow-up of 27 +/- 9 months. The mean
duration of the arrhythmia at enrollment was 59 months (range 1-360 months). Only
42 patients (6.3%) were on anticoagulants by general practitioners and 205 (30.8%)
were on antiplatelet drugs. RESULTS: Of these patients, 110 (16.5%) died: 28
(25.5%) due to a cerebral or peripheral thromboembolism, 10 (8.2%) of sudden death,
46 (42.7%) of expected cardiac death and 25 (22.7%) of non-cardiac causes. In one
patient, the cause of death was uncertain. Sixty-nine patients underwent postmortem
examination. In univariate analysis, left ventricular dysfunction (p = 0.03) and an
enlarged left atrium (p = 0.03) proved to be directly related to increased
cardiovascular mortality. Both in univariate and Cox proportional hazards model
analysis, aging (odds ratio 1.09, IC 95% 1.05-1.12, p = 0.00001), history of heart
failure (odds ratio 1.27, IC 95% 1.01-1.60, p = 0.036), cardiomegaly (odds ratio
1.35, IC 95% 1.01-1.81, p = 0.040), diabetes mellitus (odds ratio 1.35, IC 95%
0.99-1.84, p = 0.058) and previous myocardial infarction (odds ratio 1.56, IC 95%
1.20-2.03, p = 0.0007) were all independent risk factors for cardiovascular
mortality. A history of cerebral or systemic embolism (23 versus 12%, p = 0.09)
and, above all, one or more recurrences before enrollment (11 versus 2.3%, p =
0.04), were associated with embolic mortality. CONCLUSIONS: Patients with NRAF have
an increased risk of cardiovascular death. Aging, the presence of diabetes,
cardiomegaly on chest x-ray, heart failure and a previous myocardial infarction
were independent risk factors for cardiovascular mortality. A history of embolism
at enrollment significantly conditioned the embolic mortality rate but above all,
embolic events during follow-up determined a very high percentage of total deaths
(25.5% of all causes). A proper anticoagulant therapy should strongly be advised to
all patients with no contraindications.
AD - Cardiovascular Center, Maggiore Hospital, University of Trieste.
AN - 10396667
AU - Scardi, S.
AU - Mazzone, C.
AU - Pandullo, C.
AU - Goldstein, D.
AU - Di Lenarda, A.
AU - Chersevani, D.
DA - Jun
DP - NLM
ET - 1999/07/09
IS - 6
KW - Aged
Aged, 80 and over
Atrial Fibrillation/diagnosis/*mortality
Cause of Death
Chronic Disease
Female
Follow-Up Studies
Humans
Italy/epidemiology
Male
Middle Aged
Prognosis
Prospective Studies
Risk Factors
Time Factors
LA - eng
ita
N1 - Scardi, S
Mazzone, C
Pandullo, C
Goldstein, D
Di Lenarda, A
Chersevani, D
Journal Article
Italy
G Ital Cardiol. 1999 Jun;29(6):637-46.
PY - 1999
SN - 0046-5968 (Print)
0046-5968
SP - 637-46
ST - Mortality and cause of death in patients with chronic non-rheumatic atrial
fibrillation after a two-year follow-up
T2 - G Ital Cardiol
TI - Mortality and cause of death in patients with chronic non-rheumatic atrial
fibrillation after a two-year follow-up
VL - 29
ID - 2893
ER -
TY - JOUR
AB - OBJECTIVE: The authors sought to determine whether use of methylphenidate in
adults is associated with elevated rates of serious cardiovascular events compared
with rates in nonusers. METHOD: This was a cohort study of new users of
methylphenidate based on administrative data from a five-state Medicaid database
and a 14-state commercial insurance database. All new methylphenidate users with at
least 180 days of prior enrollment were identified. Users were matched on data
source, state, sex, and age to as many as four comparison subjects who did not use
methylphenidate, amphetamines, or atomoxetine. A total of 43,999 new
methylphenidate users were identified and matched to 175,955 nonusers. Events of
primary interest were 1) sudden death or ventricular arrhythmia, 2) stroke, 3)
myocardial infarction, and 4) a composite endpoint of stroke or myocardial
infarction. RESULTS: The age-standardized incidence rate per 1,000 person-years of
sudden death or ventricular arrhythmia was 2.17 (95% CI=1.63-2.83) in
methylphenidate users and 0.98 (95% CI=0.89-1.08) in nonusers, for an adjusted
hazard ratio of 1.84 (95% CI=1.33-2.55). Dosage was inversely associated with risk.
Adjusted hazard ratios for stroke, myocardial infarction, and the composite
endpoint of stroke or myocardial infarction did not differ statistically from 1.
CONCLUSIONS: Although initiation of methylphenidate was associated with a 1.8-fold
increase in risk of sudden death or ventricular arrhythmia, the lack of a dose-
response relationship suggests that this association may not be a causal one.
AD - Center for Clinical Epidemiology and Biostatistics, Department of
Biostatistics and Epidemiology, Perelman School of Medicine at the University of
Pennsylvania, Philadelphia, USA.
AN - 22318795
AU - Schelleman, H.
AU - Bilker, W. B.
AU - Kimmel, S. E.
AU - Daniel, G. W.
AU - Newcomb, C.
AU - Guevara, J. P.
AU - Cziraky, M. J.
AU - Strom, B. L.
AU - Hennessy, S.
DA - Feb
DO - 10.1176/appi.ajp.2011.11010125
DP - NLM
ET - 2012/02/10
IS - 2
J2 - The American journal of psychiatry
KW - Adult
Aged
Central Nervous System Stimulants/administration & dosage/adverse effects
Cohort Studies
Databases, Factual
*Death, Sudden, Cardiac/epidemiology/etiology
Female
Humans
Incidence
Male
Mental Disorders/drug therapy
Methylphenidate/administration & dosage/*adverse effects
Middle Aged
*Myocardial Infarction/epidemiology/etiology
Research Design
Risk Assessment
*Stroke/epidemiology/etiology
*Ventricular Fibrillation/epidemiology/etiology
LA - eng
N1 - 1535-7228
Schelleman, Hedi
Bilker, Warren B
Kimmel, Stephen E
Daniel, Gregory W
Newcomb, Craig
Guevara, James P
Cziraky, Mark J
Strom, Brian L
Hennessy, Sean
5KL2RR024132/RR/NCRR NIH HHS/United States
Journal Article
United States
Am J Psychiatry. 2012 Feb;169(2):178-85. doi: 10.1176/appi.ajp.2011.11010125.
PY - 2012
SN - 0002-953x
SP - 178-85
ST - Methylphenidate and risk of serious cardiovascular events in adults
T2 - Am J Psychiatry
TI - Methylphenidate and risk of serious cardiovascular events in adults
VL - 169
ID - 2632
ER -
TY - JOUR
AB - MAIN OBJECTIVE: To compare the incidence rates of serious cardiovascular
events in adult initiators of amphetamines or atomoxetine to rates in non-users.
METHODS: This was a retrospective cohort study of new amphetamines (n=38,586) or
atomoxetine (n=20,995) users. Each medication user was matched to up to four non-
users on age, gender, data source, and state (n=238,183). The following events were
primary outcomes of interest 1) sudden death or ventricular arrhythmia, 2) stroke,
3) myocardial infarction, 4) a composite endpoint of stroke or myocardial
infarction. Cox proportional hazard regression was used to calculate propensity-
adjusted hazard ratios for amphetamines versus matched non-users and atomoxetine
versus matched non-users, with intracluster dependence within matched sets
accounted for using a robust sandwich estimator. RESULTS: The propensity-score
adjusted hazard ratio for amphetamines use versus non-use was 1.18 (95% CI: 0.55-
2.54) for sudden death/ventricular arrhythmia, 0.80 (95% CI: 0.44-1.47) for stroke,
0.75 (95% CI: 0.42-1.35) for myocardial infarction, and 0.78 (95% CI: 0.51-1.19)
for stroke/myocardial infarction. The propensity-score adjusted hazard ratio for
atomoxetine use versus non-use was 0.41 (95% CI: 0.10-1.75) for sudden
death/ventricular arrhythmia, 1.30 (95% CI: 0.52-3.29) for stroke, 0.56 (95% CI:
0.16-2.00) for myocardial infarction, and 0.92 (95% CI: 0.44-1.92) for
stroke/myocardial infarction. CONCLUSIONS: Initiation of amphetamines or
atomoxetine was not associated with an elevated risk of serious cardiovascular
events. However, some of the confidence intervals do not exclude modest elevated
risks, e.g. for sudden death/ventricular arrhythmia.
AD - Center for Clinical Epidemiology and Biostatistics, and Department of
Biostatistics & Epidemiology, Perelman School of Medicine at the University of
Pennsylvania, Philadelphia, Pennsylvania, United States of America.
AN - 23382829
AU - Schelleman, H.
AU - Bilker, W. B.
AU - Kimmel, S. E.
AU - Daniel, G. W.
AU - Newcomb, C.
AU - Guevara, J. P.
AU - Cziraky, M. J.
AU - Strom, B. L.
AU - Hennessy, S.
C2 - PMC3559703 following conflicts. All authors received salary support from
Shire through their employer. Dr. Schelleman has had travel to scientific
conferences paid for by pharmacoepidemiology training funds contributed by
pharmaceutical manufacturers. Dr. Bilker has consulted for Johnson and Johnson,
unrelated to ADHD medications. Dr. Kimmel has consulted for Novartis,
GlaxoSmithKline, Ortho-McNeil, and other pharmaceutical companies, all unrelated to
ADHD medications. Drs. Daniel and Cziraky are employed by HealthCore Inc. which
conducts research for and receives funding from pharmaceutical manufacturers for
research services. Dr. Strom is the principal investigator of a training program
funded in part by Abbott and Novartis and has consulted for several pharmaceutical
companies that make ADHD medications, unrelated to these drugs. Dr. Hennessy has
had grant funding from Abbott and has consulted for Abbott and Teva, unrelated to
ADHD medications. This does not alter the authors' adherence to all the PLOS ONE
policies on sharing data and materials.
DO - 10.1371/journal.pone.0052991
DP - NLM
ET - 2013/02/06
IS - 1
J2 - PloS one
KW - Adrenergic Uptake Inhibitors/administration & dosage/*adverse effects
Amphetamines/administration & dosage/*adverse effects
Arrhythmias, Cardiac/chemically induced/physiopathology
Atomoxetine Hydrochloride
Cardiovascular Abnormalities/*chemically induced/physiopathology
Death, Sudden/pathology
Drug-Related Side Effects and Adverse Reactions/*chemically
induced/epidemiology/physiopathology
Female
Humans
Male
Myocardial Infarction/chemically induced/physiopathology
Propylamines/administration & dosage/*adverse effects
Stroke/chemically induced/physiopathology
LA - eng
N1 - 1932-6203
Schelleman, Hedi
Bilker, Warren B
Kimmel, Stephen E
Daniel, Gregory W
Newcomb, Craig
Guevara, James P
Cziraky, Mark J
Strom, Brian L
Hennessy, Sean
UL1RR024134/RR/NCRR NIH HHS/United States
Journal Article
PLoS One. 2013;8(1):e52991. doi: 10.1371/journal.pone.0052991. Epub 2013 Jan 30.
PY - 2013
SN - 1932-6203
SP - e52991
ST - Amphetamines, atomoxetine and the risk of serious cardiovascular events in
adults
T2 - PLoS One
TI - Amphetamines, atomoxetine and the risk of serious cardiovascular events in
adults
VL - 8
ID - 2559
ER -
TY - JOUR
AB - OBJECTIVE: the aim of the study is to investigate the effect of thrombolytic
therapy on neurological outcome in patients after cardiac arrest due to acute
myocardial infarction. Laboratory investigations have demonstrated that
thrombolytic therapy after cardiopulmonary resuscitation improves neurological
function. METHODS: from July 1991 to June 1996, patients with witnessed ventricular
fibrillation cardiac arrest due to acute MI and successful restoration of
spontaneous circulation admitted to the emergency department were analyzed
retrospectively. A logistic regression model was used to assess the association
between thrombolytic therapy and neurological outcome [best cerebral performance
category (CPC) within 6 months after cardiac arrest]. RESULTS: all 157 patients
[median age 57 years (IQR 50-69)] were analyzed. Thrombolytic therapy was applied
in 42 patients (27%). With thrombolytic therapy good functional neurological
recovery (CPC 1 or 2) was achieved more frequently (69 vs. 50%, P=0.03). After
controlling for age, prehospital dosage of epinephrine, and the duration of cardiac
arrest we found a non significant trend towards good neurological recovery when
thrombolytic therapy was given (OR 1.9, 95% CI 0.8-4.6). CONCLUSION: thrombolytic
therapy after cardiac arrest due to acute myocardial infarction is associated with
improved neurological outcome.
AD - Universitätsklinik für Notfallmedizin, Allgemeines Krankenhaus der Stadt
Wien, Währinger Gürtel 18-20/6/D, 1090 Vienna, Austria.
AN - 11801350
AU - Schreiber, W.
AU - Gabriel, D.
AU - Sterz, F.
AU - Muellner, M.
AU - Kuerkciyan, I.
AU - Holzer, M.
AU - Laggner, A. N.
DA - Jan
DO - 10.1016/s0300-9572(01)00432-4
DP - NLM
ET - 2002/01/22
IS - 1
J2 - Resuscitation
KW - Aged
Cardiopulmonary Resuscitation/methods
Cerebrovascular Circulation/*drug effects/physiology
Confidence Intervals
Female
Heart Arrest/*drug therapy/etiology/mortality/therapy
Humans
Logistic Models
Male
Middle Aged
Myocardial Infarction/complications/therapy
Probability
Reference Values
Survival Analysis
Ventricular Fibrillation/etiology/therapy
LA - eng
N1 - Schreiber, W
Gabriel, D
Sterz, F
Muellner, M
Kuerkciyan, I
Holzer, M
Laggner, A N
Comparative Study
Journal Article
Ireland
Resuscitation. 2002 Jan;52(1):63-9. doi: 10.1016/s0300-9572(01)00432-4.
PY - 2002
SN - 0300-9572 (Print)
0300-9572
SP - 63-9
ST - Thrombolytic therapy after cardiac arrest and its effect on neurological
outcome
T2 - Resuscitation
TI - Thrombolytic therapy after cardiac arrest and its effect on neurological
outcome
VL - 52
ID - 3011
ER -
TY - JOUR
AB - AIMS: Left atrial catheter ablation of the pulmonary veins (PV) has evolved
as an important therapeutic option for the treatment of atrial fibrillation (AF).
We aimed to investigate the incidence and predictors of silent cerebral embolism
associated with PV catheter ablation, detected by diffusion-weighted magnetic
resonance imaging (DW-MRI). METHODS AND RESULTS: We performed a prospective
analysis of 53 consecutive patients with persistent or paroxysmal AF that underwent
PV ablation and post-procedural cerebral MRI 1 day after lasso catheter-guided
ostial PV ablation. Patients were analysed for possible demographical, medical,
echocardiographical, and procedural predictors of embolic events. A mean of 3.5 +/-
0.5 PVs were ablated per patient. In six patients, DW-MRI depicted new clinically
silent microembolism after PV ablation (11%). The number of ineffective medical
antiarrhythmic agents prior to ablation procedure was significantly higher in the
embolism group (3.3 +/- 0.5 vs. 2.2 +/- 1.4, P = 0.014). Coronary heart disease
(CAD) was more frequent in patients with cerebral embolisms (33 vs. 2%, P = 0.031);
left ventricular volume (130 +/- 12 vs. 103 +/- 26 mL, P = 0.002), and septal wall
thickness (13.0 +/- 1.4 vs. 7.9 +/- 4.8 mm, P = 0.025) were significantly
increased. CONCLUSION: This study shows a high incidence of silent micro-embolic
events after PV ablation. CAD, left ventricular dilatation, and hypertrophy were
potential predictors of this complication.
AD - Department of Medicine-Cardiology, University of Bonn, Sigmund Freud Strasse
25, Bonn 53105, Germany. jan.schrickel@ukb.uni-bonn.de
AN - 19933517
AU - Schrickel, J. W.
AU - Lickfett, L.
AU - Lewalter, T.
AU - Mittman-Braun, E.
AU - Selbach, S.
AU - Strach, K.
AU - Nähle, C. P.
AU - Schwab, J. O.
AU - Linhart, M.
AU - Andrié, R.
AU - Nickenig, G.
AU - Sommer, T.
DA - Jan
DO - 10.1093/europace/eup350
DP - NLM
ET - 2009/11/26
IS - 1
KW - Atrial Fibrillation/*epidemiology/*surgery
Catheter Ablation/*statistics & numerical data
Comorbidity
Female
Germany/epidemiology
Humans
Incidence
Intracranial Embolism/*epidemiology
Magnetic Resonance Imaging/statistics & numerical data
Male
Middle Aged
Risk Factors
LA - eng
N1 - 1532-2092
Schrickel, Jan Wilko
Lickfett, Lars
Lewalter, Thorsten
Mittman-Braun, Erica
Selbach, Stephanie
Strach, Katharina
Nähle, Claas P
Schwab, Jörg Otto
Linhart, Markus
Andrié, Rene
Nickenig, Georg
Sommer, Torsten
Clinical Trial
Journal Article
England
Europace. 2010 Jan;12(1):52-7. doi: 10.1093/europace/eup350.
PY - 2010
SN - 1099-5129
SP - 52-7
ST - Incidence and predictors of silent cerebral embolism during pulmonary vein
catheter ablation for atrial fibrillation
T2 - Europace
TI - Incidence and predictors of silent cerebral embolism during pulmonary vein
catheter ablation for atrial fibrillation
VL - 12
ID - 2918
ER -
TY - JOUR
AB - The clinical spectrum of obstructive sleep apnea-(OSA-)related cardiovascular
disease (CVD) comprises systemic arterial hypertension (prevalence: 40-60%),
pulmonary hypertension (20-30%), coronary artery disease (20-30%), congestive heart
failure (5-10%), and stroke (5-10%). During sleep, heart rhythm disorders such as
atrioventricular blocks, sinus arrests and atrial fibrillation can be induced by
OSA. OSA-related CVD mainly affects those patients with an apnea-hypopnea index >
30/h and, if left untreated, is linked to increased mortality. Epidemiologic data
have clearly shown that cardiovascular risk is increased in OSA independent of
confounding factors such as obesity and concomitant metabolic disease. In recent
years, the pathophysiology of OSA-related CVD has been further elucidated showing
that apart from the well-known sympathetic activation, increased oxidative stress
and pro-inflammatory changes seem to play major roles. Furthermore, studies using
high resolution ultrasonography have demonstrated endothelial dysfunction and
enhanced atherosclerosis in these patients. Finally, animal models of OSA have
delineated that daytime arterial hypertension is the consequence of the OSA-
associated chronic intermittent hypoxia. Therapy of OSA by continuous positive
airway pressure (CPAP) ventilation exerts cardioprotective effects. It has been
shown to rectify the vascular micromilieu, restore endothelium-dependent
vasodilation, lower 24-h blood pressure, eliminate nocturnal heart rhythm
disorders, and improve left ventricular function. Furthermore, long-term CPAP
therapy leads to a reduction in important clinical endpoints such as the rates of
myocardial infarction and stroke.
AD - Medizinische Klinik II/Schlaflabor, Universitätsklinikum Giessen und Marburg,
Standort Giessen, 35392 Giessen. Richard.Schulz@innere.med.uni-giessen.de
AN - 16607489
AU - Schulz, R.
AU - Grebe, M.
AU - Eisele, H. J.
AU - Mayer, K.
AU - Weissmann, N.
AU - Seeger, W.
DA - Apr 15
DO - 10.1007/s00063-006-1041-9
DP - NLM
ET - 2006/04/12
IS - 4
J2 - Medizinische Klinik (Munich, Germany : 1983)
KW - Animals
*Continuous Positive Airway Pressure
Dogs
Endothelium, Vascular/physiopathology
Humans
Hypertension, Pulmonary/epidemiology
Oxidative Stress
Prevalence
Rats
Risk Factors
Sleep Apnea, Obstructive/*complications/physiopathology/*therapy
Stroke/epidemiology
Time Factors
LA - ger
N1 - Schulz, Richard
Grebe, Mathias
Eisele, Hans-Joachim
Mayer, Konstantin
Weissmann, Norbert
Seeger, Werner
Comparative Study
English Abstract
Journal Article
Review
Germany
Med Klin (Munich). 2006 Apr 15;101(4):321-7. doi: 10.1007/s00063-006-1041-9.
OP - Vaskuläre Folgeerkrankungen bei obstruktiver Schlafapnoe.
PY - 2006
SN - 0723-5003 (Print)
0723-5003
SP - 321-7
ST - [Obstructive sleep apnea-related cardiovascular disease]
T2 - Med Klin (Munich)
TI - [Obstructive sleep apnea-related cardiovascular disease]
VL - 101
ID - 2504
ER -
TY - JOUR
AB - OBJECTIVE: To assess use of thromboprophylaxis in UK general practise among
patients with atrial fibrillation (AF); to investigate whether elderly patients are
less likely to receive anticoagulation therapy than younger patients. DESIGN:
Retrospective cohort study SETTING: UK General Practice Research Database (GPRD)
PATIENTS: Aged ≥60 years with a new diagnosis of AF (2000-2009). INTERVENTIONS:
None. MAIN OUTCOME MEASURES: The main outcome measure was initiation of warfarin in
the first year following diagnosis. Patients were categorised by stroke risk
(CHADS(2) score) and bleeding risk (HAS-BLED score). RESULTS: 81 381 patients were
identified (21% aged 60-69 years, 37% aged 70-79 years, 42% aged 80+ years).
Patients aged 80+ years were significantly less likely to be initiated on warfarin
than younger patients, adjusted for gender, practice and comorbidities; 32% of
patients aged 80+ years received warfarin compared with 57% aged 60-69 years
(p<0.0001), and 55% aged 70-79 years (p<0.0001). For all strata of CHADS(2)/HASBLED
scores, patients aged 80+ years were significantly less likely to be treated with
warfarin than younger patients. Logistic regression showed that female sex, low
Basal Metabolic Index (BMI), age over 80 years, increasing HAS-BLED score and
dementia were independently associated with reduced use of warfarin.
Stroke/Transient Ischaemic Attack (TIA), hypertension, heart failure and left
ventricular systolic dysfunction were associated with increased use. Patients with
HAS-BLED>CHADS(2) were less likely to be initiated on warfarin. Higher CHADS(2)
scores were associated with increased anticoagulation use. CONCLUSIONS:
Anticoagulation is being under-used in patients with AF aged 80+ years, even after
taking into account increased bleeding risk in this age group.
AD - Boehringer Ingelheim, Bracknell, UK.
AN - 23086966
AU - Scowcroft, A. C.
AU - Lee, S.
AU - Mant, J.
C2 - PMC3551210
DA - Jan
DO - 10.1136/heartjnl-2012-302843
DP - NLM
ET - 2012/10/23
IS - 2
KW - Age Factors
Aged
Aged, 80 and over
Databases, Factual
Female
Follow-Up Studies
General Practice/*statistics & numerical data
Humans
Incidence
Male
Middle Aged
*Registries
Risk Assessment
Risk Factors
Thrombosis/epidemiology/etiology/*prevention & control
Treatment Outcome
LA - eng
N1 - 1468-201x
Scowcroft, Anna C E
Lee, Sally
Mant, Jonathan
Comparative Study
Journal Article
Heart. 2013 Jan;99(2):127-32. doi: 10.1136/heartjnl-2012-302843. Epub 2012 Oct 19.
PY - 2013
SN - 1355-6037 (Print)
1355-6037
SP - 127-32
ST - Thromboprophylaxis of elderly patients with AF in the UK: an analysis using
the General Practice Research Database (GPRD) 2000-2009
T2 - Heart
TI - Thromboprophylaxis of elderly patients with AF in the UK: an analysis using
the General Practice Research Database (GPRD) 2000-2009
VL - 99
ID - 3025
ER -
TY - JOUR
AB - Atrial fibrillation (AF) is associated with rapid ventricular response (RVR)
that increases myocardial demand and blood pressure instability. We investigated
the incidence, risk factors, and outcomes of RVR among patients with ischemic
stroke receiving treatment with intravenous (IV) recombinant tissue plasminogen
activator (rtPA). Consecutive patients with AF who received IV rtPA within 3 hours
of symptom onset were included. Vascular risk factors, stroke characteristics, and
outcome measures were compared between patients who developed RVR and those who did
not. Eighty patients with AF (mean age, 79 years; 46% men) who underwent rtPA
treatment were studied. Nineteen (24%) of these patients developed RVR and were
treated with IV rate-controlling medications. A bimodal pattern of distribution was
observed in the occurrence of RVR, with the first peak occurring within 12 hours of
stroke onset and the second peak occurring 24-48 hours after onset. Compared with
the patients without RVR, those with RVR stayed a median duration of 1.2 days
longer in the intensive care unit (P = .048). There were no differences in
functional recovery and hemorrhagic outcomes between the patients with RVR and
those without RVR. We observed a 16-hour delay in the resumption of antiarrhythmic
medications (either at previous or reduced dosage) in the patients who subsequently
developed RVR (median time from stroke onset, 29 hours vs 13 hours; P = .040). Our
findings suggest that a delay in the resumption of rate-control medications in
patients with AF may result in RVR and prolong the use of intensive care resources.
AD - Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA.
raymond_seet@nus.edu.sg
AN - 21855367
AU - Seet, R. C.
AU - Zhang, Y.
AU - Rabinstein, A. A.
AU - Wijdicks, E. F.
DA - Feb
DP - NLM
ET - 2011/08/23
IS - 2
KW - Aged
Aged, 80 and over
Anti-Arrhythmia Agents/administration & dosage/adverse effects
Atrial Fibrillation/drug therapy/*epidemiology/prevention & control
Brain Ischemia/*drug therapy/*epidemiology
Critical Care/methods
Female
Fibrinolytic Agents/administration & dosage
Heart Rate/drug effects/physiology
Humans
Incidence
Injections, Intravenous
Male
Recombinant Proteins/administration & dosage
Risk Factors
Stroke/*drug therapy/*epidemiology
Substance Withdrawal Syndrome/prevention & control
Tissue Plasminogen Activator/*administration & dosage
LA - eng
N1 - 1532-8511
Seet, Raymond C S
Zhang, Yi
Rabinstein, Alejandro A
Wijdicks, Eelco F M
Journal Article
United States
10.1016/j.jstrokecerebrovasdis.2011.07.001. Epub 2011 Sep 8.
PY - 2013
SN - 1052-3057
SP - 161-5
ST - Risk factors and consequences of atrial fibrillation with rapid ventricular
response in patients with ischemic stroke treated with intravenous thrombolysis
TI - Risk factors and consequences of atrial fibrillation with rapid ventricular
response in patients with ischemic stroke treated with intravenous thrombolysis
VL - 22
ID - 2357
ER -
TY - JOUR
AB - BACKGROUND AND PURPOSE: Left ventricular diastolic dysfunction (LVDD) is a
predictor for atrial fibrillation (AF). This study was aimed to investigate whether
LVDD in cryptogenic ischemic stroke (CS) could be a clue to stroke mechanism.
METHODS: The clinical and echocardiographic findings of 1589 consecutive patients
with acute ischemic stroke or transient ischemic attack between 2004 and 2013 were
reviewed. LVDDs among stroke subtypes were graded by transthoracic echocardiography
into 4 groups by severity: normal, abnormal relaxation (grade I), pseudonormal
(grade II), and restrictive diastolic filling (grade III), whereas severe LVDD was
defined as grade III. We classified the lesion pattern of CS into cardioembolism-
mimic or non-cardioembolism-mimic and determined whether cardioembolism-mimic
lesions were associated with severe LVDD. RESULTS: The fraction of severe LVDD in
CS was not different from that of stroke with AF (27.3% versus 37.1%; P=0.173) but
was significantly higher than that of stroke without AF (27.3% versus 13.4%;
P=0.008). Cardioembolism-mimic CS had more severe LVDD than non-cardioembolism-
mimic CS (41.4% versus 11.5%; P=0.013). LVDD of grade II (odds ratio, 4.37; 95%
confidence interval, 2.99-6.41) and grade III (odds ratio, 5.60; 95% confidence
interval, 3.42-9.17) were independently related to stroke with AF after adjusting
covariates. CONCLUSIONS: The severe LVDD could be a predictor of stroke with AF,
and its frequency was similar between CS and stroke with AF. Cardioembolism-mimic
CS had significantly more severe LVDD than non-cardioembolism-mimic CS. LVDD could
be helpful to discriminate the stroke mechanism in the patients with acute CS.
AD - From the Departments of Neurology (J.-Y.S., K.B.L., J.-G.L., J.-S.K., H.R.,
M.-Y.A.) and Cardiology (B.W.P., M.S.H.), Soonchunhyang University School of
From the Departments of Neurology (J.-Y.S., K.B.L., J.-G.L., J.-S.K., H.R., M.-
Y.A.) and Cardiology (B.W.P., M.S.H.), Soonchunhyang University School of Medicine,
Seoul, Korea. kblee@schmc.ac.kr.
AN - 25074516
AU - Seo, J. Y.
AU - Lee, K. B.
AU - Lee, J. G.
AU - Kim, J. S.
AU - Roh, H.
AU - Ahn, M. Y.
AU - Park, B. W.
AU - Hyon, M. S.
DA - Sep
DO - 10.1161/strokeaha.114.006108
DP - NLM
ET - 2014/07/31
IS - 9
J2 - Stroke
KW - Adult
Aged
Atrial Fibrillation/complications/physiopathology
Brain/pathology
Echocardiography
Female
Humans
Ischemia/*complications/physiopathology
Male
Middle Aged
Odds Ratio
Risk Factors
Stroke/*complications/physiopathology
Treatment Outcome
Ventricular Dysfunction, Left/*complications/diagnostic imaging
atrial fibrillation
stroke
LA - eng
N1 - 1524-4628
Seo, Jae-Young
Lee, Kyung Bok
Lee, Jung-Gon
Kim, Ji-Sun
Roh, Hakjae
Ahn, Moo-Young
Park, Byoung Won
Hyon, Min Su
Journal Article
United States
Stroke. 2014 Sep;45(9):2757-61. doi: 10.1161/STROKEAHA.114.006108. Epub 2014 Jul
29.
PY - 2014
SN - 0039-2499
SP - 2757-61
ST - Implication of left ventricular diastolic dysfunction in cryptogenic ischemic
stroke
T2 - Stroke
TI - Implication of left ventricular diastolic dysfunction in cryptogenic ischemic
stroke
VL - 45
ID - 2448
ER -
TY - JOUR
AB - Fatal bilateral cerebro-vascular accident with variable atrio-ventricular
blocks, atrial fibrillation and refractory tachy-arrhythmias in a previously
healthy 75-years-old hypertensive female is presented.
AD - Department of Medicine, JLN Hospital and Research Centre, Bhilai,
Chattisgarh.
AN - 20329447
AU - Sethi, S. K.
AU - Sarm, P. S.
DA - Nov
DP - NLM
ET - 2010/03/25
J2 - The Journal of the Association of Physicians of India
KW - Aged
Atrioventricular Block/*etiology
Electrocardiography
Fatal Outcome
Female
Humans
Recurrence
Tachycardia/*etiology
LA - eng
N1 - Sethi, S K
Sarm, P S A
Case Reports
Journal Article
India
J Assoc Physicians India. 2009 Nov;57:770-2.
PY - 2009
SN - 0004-5772 (Print)
0004-5772
SP - 770-2
ST - Elderly woman with cerebrovascular accident and refractory arrhythmias
T2 - J Assoc Physicians India
TI - Elderly woman with cerebrovascular accident and refractory arrhythmias
VL - 57
ID - 2735
ER -
TY - JOUR
AB - BACKGROUND: Low-dose continuous human atrial natriuretic peptide (hANP)
administration during cardiac surgery has been reported on previously. In the
present study, the efficacy of the therapy during emergent coronary artery bypass
grafting (CABG) for acute coronary syndrome (ACS) is investigated. METHODS AND
RESULTS: One hundred and twenty-four patients patients undergoing emergent CABG for
ACS were divided into 2 groups; a group receiving administration of hANP (hANP
group) and a group not receiving hANP infusion (non-hANP group). The postoperative
peak levels of creatine kinase-MB were significantly lower in the hANP group as
compared with those in the non-hANP group. The incidence of postoperative
arrhythmias was also significantly lower in the hANP group as compared with that in
the non-hANP group. The postoperative brain natriuretic peptide was significantly
lower in the hANP group as compared with that in the non-hANP group until 1 year
after the operation. The free-rate of cardiac events after the operation was also
significantly higher in the hANP group as compared with that in the non-hANP group.
CONCLUSIONS: It is therefore considered that hANP might not only be effective for
overcoming some major shortcomings of cardiopulmonary bypass, but also might be
effective to attenuate ischemia-reperfusion injury, protect the myocardium, have an
anti-arrhythmic effect, and suppress left ventricular remodeling.
AD - Department of Cardiovascular Surgery, Nihon University School of Medicine,
Tokyo, Japan. asezai@med.nihon-u.ac.jp
AN - 17721018
AU - Sezai, A.
AU - Hata, M.
AU - Wakui, S.
AU - Niino, T.
AU - Takayama, T.
AU - Hirayama, A.
AU - Saito, S.
AU - Minami, K.
DA - Sep
DO - 10.1253/circj.71.1401
DP - NLM
ET - 2007/08/28
IS - 9
KW - Acute Coronary Syndrome/blood/*surgery
Aged
Arrhythmias, Cardiac/blood/*prevention & control
Atrial Natriuretic Factor/*administration & dosage
Female
Humans
Male
Middle Aged
Myocardial Reperfusion Injury/blood/*prevention & control
Ventricular Remodeling/*drug effects
LA - eng
N1 - Sezai, Akira
Hata, Mitsumasa
Wakui, Shinji
Niino, Tetsuya
Takayama, Tadateru
Hirayama, Atsushi
Saito, Satoshi
Minami, Kazutomo
Comparative Study
Journal Article
Japan
Circ J. 2007 Sep;71(9):1401-7. doi: 10.1253/circj.71.1401.
PY - 2007
SN - 1346-9843 (Print)
1346-9843
SP - 1401-7
ST - Efficacy of continuous low-dose hANP administration in patients undergoing
emergent coronary artery bypass grafting for acute coronary syndrome
T2 - Circ J
TI - Efficacy of continuous low-dose hANP administration in patients undergoing
emergent coronary artery bypass grafting for acute coronary syndrome
VL - 71
ID - 2931
ER -
TY - JOUR
AB - BACKGROUND: The aim of the present study was to evaluate the efficacy of
alpha-human atrial natriuretic peptide (hANP) in cardiac surgery under
cardiopulmonary bypass (CPB). METHODS AND RESULTS: A prospective randomized study
was conducted with 150 patients who underwent scheduled coronary artery bypass
grafting to compare a group of patients receiving 0.02 microg x kg(-1) x min(-1) of
hANP from the initiation of CPB with a group not receiving hANP. Hemodynamics,
levels of atrial and brain natriuretic peptides (BNP), angiotensin-II and
aldosterone, renin activity, and left ventricular (LV) function were examined. The
hANP group showed significantly lower renin activity and lower levels of
angiotensin-II and aldosterone during the early postoperative period, compared with
the non-hANP group. The incidence of postoperative ventricular arrhythmia and the
postoperative peak level of creatine kinase-MB were significantly lower in the hANP
group. BNP at 1 month after surgery and measures of LV function were also
significantly lower in the hANP group. CONCLUSIONS: Low-dose continuous infusion of
hANP during cardiac surgery not only had a compensatory effect for the
imperfections of CPB during the early postoperative period but also an inhibitory
effect on postoperative LV remodeling and a reduction in ischemia/reperfusion
injury. hANP should be part of the postoperative care for cardiac surgery.
Tokyo 173-8610, Japan. asezai@med.nihon-u.ac.jp
AN - 17062965
AU - Sezai, A.
AU - Hata, M.
AU - Wakui, S.
AU - Shiono, M.
AU - Negishi, N.
AU - Kasamaki, Y.
AU - Saito, S.
AU - Kato, J.
AU - Minami, K.
DA - Nov
DO - 10.1253/circj.70.1426
DP - NLM
ET - 2006/10/26
IS - 11
KW - Aged
Aldosterone/blood
Atrial Natriuretic Factor/administration & dosage/pharmacology/*therapeutic use
Blood Pressure/drug effects/physiology
Cardiopulmonary Bypass/*methods
Coronary Artery Disease/surgery
Creatine Kinase, MB Form/blood
Female
Humans
Male
Middle Aged
Renin/blood
Reperfusion Injury/physiopathology/prevention & control
Ventricular Function, Left/*drug effects/physiology
Ventricular Remodeling/*drug effects/physiology
LA - eng
N1 - Sezai, Akira
Hata, Mitsumasa
Wakui, Shinji
Shiono, Motomi
Negishi, Nanao
Kasamaki, Yuji
Saito, Satoshi
Kato, Jitsu
Minami, Kazutomo
Journal Article
Japan
Circ J. 2006 Nov;70(11):1426-31. doi: 10.1253/circj.70.1426.
PY - 2006
SN - 1346-9843 (Print)
1346-9843
SP - 1426-31
ST - Efficacy of low-dose continuous infusion of alpha-human atrial natriuretic
peptide (hANP) during cardiac surgery: possibility of postoperative left
ventricular remodeling effect
T2 - Circ J
TI - Efficacy of low-dose continuous infusion of alpha-human atrial natriuretic
peptide (hANP) during cardiac surgery: possibility of postoperative left
ventricular remodeling effect
VL - 70
ID - 3000
ER -
TY - JOUR
AB - OBJECTIVES: We previously conducted a prospective study of landiolol
hydrochloride (INN landiolol), an ultrashort-acting β-blocker, and reported that it
could prevent atrial fibrillation after cardiac surgery. This trial was performed
to investigate the safety and efficacy of landiolol hydrochloride in patients with
left ventricular dysfunction undergoing cardiac surgery. METHODS: Sixty patients
with a preoperative left ventricular ejection fraction of less than 35% were
randomly assigned to 2 groups before cardiac surgery and then received intravenous
infusion with landiolol hydrochloride (landiolol group) or without landiolol
(control group). The primary end point was occurrence of atrial fibrillation as
much as 1 week postoperatively. The secondary end points were blood pressure, heart
rate, intensive care unit and hospital stays, ventilation time, ejection fraction,
biomarkers of ischemia, and brain natriuretic peptide. RESULTS: Atrial fibrillation
occurred in 3 patients (10%) in the landiolol group versus 12 (40%) in the control
group, and its frequency was significantly lower in the landiolol group (P = .002).
During the early postoperative period, levels of brain natriuretic peptide and
ischemic biomarkers were significantly lower in the landiolol group than the
control group. The landiolol group also had a significantly shorter hospital stay
(P = .019). Intravenous infusion was not discontinued for hypotension or
bradycardia in either group. CONCLUSIONS: Low-dose infusion of landiolol
hydrochloride prevented atrial fibrillation after cardiac surgery in patients with
cardiac dysfunction and was safe, with no effect on blood pressure. This
intravenous β-blocker seems useful for perioperative management of cardiac surgical
patients with left ventricular dysfunction.
Tokyo, Japan. Electronic address: asezai.med@gmail.com.
Department of Cardiovascular Surgery, Nihon University School of Medicine, Tokyo,
Japan.
AN - 26254752
AU - Sezai, A.
AU - Osaka, S.
AU - Yaoita, H.
AU - Ishii, Y.
AU - Arimoto, M.
AU - Hata, H.
AU - Shiono, M.
DA - Oct
DO - 10.1016/j.jtcvs.2015.07.003
DP - NLM
ET - 2015/08/10
IS - 4
KW - Aged
Aged, 80 and over
Anti-Arrhythmia Agents/adverse effects/*therapeutic use
Atrial Fibrillation/*prevention & control
Female
Humans
Male
Morpholines/adverse effects/*therapeutic use
Prospective Studies
Urea/adverse effects/*analogs & derivatives/therapeutic use
Ventricular Dysfunction, Left/*surgery
atrial fibrillation
beta blocker
cardiac surgery
left ventricular dysfunction
LA - eng
N1 - 1097-685x
Sezai, Akira
Osaka, Shunji
Yaoita, Hiroko
Ishii, Yusuke
Arimoto, Munehito
Hata, Hiroaki
Shiono, Motomi
Journal Article
United States
J Thorac Cardiovasc Surg. 2015 Oct;150(4):957-64. doi: 10.1016/j.jtcvs.2015.07.003.
Epub 2015 Jul 10.
PY - 2015
SN - 0022-5223
SP - 957-64
ST - Safety and efficacy of landiolol hydrochloride for prevention of atrial
fibrillation after cardiac surgery in patients with left ventricular dysfunction:
Prevention of Atrial Fibrillation After Cardiac Surgery With Landiolol
Hydrochloride for Left Ventricular Dysfunction (PLATON) trial
TI - Safety and efficacy of landiolol hydrochloride for prevention of atrial
fibrillation after cardiac surgery in patients with left ventricular dysfunction:
Prevention of Atrial Fibrillation After Cardiac Surgery With Landiolol
Hydrochloride for Left Ventricular Dysfunction (PLATON) trial
VL - 150
ID - 3005
ER -
TY - JOUR
AB - OBJECTIVE: To determine whether the atrial-based pacing modalities
("physiologic pacing") improve survival when compared with single-chamber
ventricular pacing in patients with the sick sinus syndrome. DESIGN: Retrospective,
nonrandomized study. SETTING: A tertiary care teaching hospital. PATIENTS: A total
of 507 patients with a mean age of 66 years who received an initial pacemaker for
the sick sinus syndrome between January 1980 and December 1989. Pacing modes were
ventricular (22%), atrial (4%), and dual-chamber (74%). MEASUREMENTS: Total and
cardiovascular mortality rates. Mean follow-up was 66 months. RESULTS: Independent
predictors of total mortality by the Cox proportional hazards model were 1) New
York Heart Association functional class (hazard ratio = 1.67/class; 95% Cl, 1.31 to
2.11); 2) age (hazard ratio = 1.62/12-year increment; Cl, 1.28 to 2.05); 3)
peripheral vascular disease (hazard ratio = 2.21; Cl, 1.42 to 3.42); 4) bundle
branch block (hazard ratio = 2.04; Cl, 1.33 to 3.13); 5) coronary artery disease
(hazard ratio = 1.66; Cl, 1.15 to 2.39); and 6) valvular heart disease (hazard
ratio = 1.71; Cl, 1.08 to 2.69). The same variables were independent predictors of
cardiovascular mortality, with cerebrovascular disease reaching borderline
statistical significance (hazard ratio = 1.69; Cl, 1.00 to 2.86). Using univariate
analysis, single-chamber ventricular pacing had more than 40% increased risk for
both total and cardiovascular death, but the difference was of borderline
statistical significance (total mortality: P = 0.053; hazard ratio = 1.43; Cl, 0.99
to 2.07; cardiovascular mortality: P = 0.15; hazard ratio = 1.41; Cl = 0.87 to
2.29). CONCLUSIONS: Because the role of the ventricular pacing mode as a long-term
predictor of total and cardiovascular mortality remains inconclusive, a large,
randomized study is necessary to confirm whether physiologic pacing provides a
substantial reduction in mortality when compared with ventricular pacing.
AD - Department of Cardiology, Cleveland Clinic Foundation, OH 44195.
AN - 8338288
AU - Sgarbossa, E. B.
AU - Pinski, S. L.
AU - Maloney, J. D.
DA - Sep 1
DO - 10.7326/0003-4819-119-5-199309010-00002
DP - NLM
ET - 1993/09/01
IS - 5
KW - Aged
Echocardiography
Female
Follow-Up Studies
Humans
Male
Sick Sinus Syndrome/*mortality/*therapy
Survival Analysis
Treatment Outcome
LA - eng
N1 - Sgarbossa, E B
Pinski, S L
Maloney, J D
Comparative Study
Journal Article
United States
Ann Intern Med. 1993 Sep 1;119(5):359-65. doi: 10.7326/0003-4819-119-5-199309010-
00002.
PY - 1993
SN - 0003-4819 (Print)
0003-4819
SP - 359-65
ST - The role of pacing modality in determining long-term survival in the sick
sinus syndrome
T2 - Ann Intern Med
TI - The role of pacing modality in determining long-term survival in the sick
sinus syndrome
VL - 119
ID - 2959
ER -
TY - JOUR
AB - BACKGROUND: The goal of the report was to study the long-term incidence and
the independent predictors for chronic atrial fibrillation and stroke in 507 paced
patients with sick sinus syndrome, adjusting for differences in baseline clinical
variables with multivariate analysis. METHODS AND RESULTS: From 1980 to 1989, we
implanted 376 dual-chamber, 19 atrial, and 112 ventricular pacemakers to treat
patients with sick sinus syndrome. After a maximum follow-up of 134 months (mean:
59 +/- 38 months for chronic atrial fibrillation, 65 +/- 37 months for stroke),
actuarial incidence of chronic atrial fibrillation was 7% at 1 year, 16% at 5
years, and 28% at 10 years. Independent predictors for this event, from Cox's
proportional hazards model, were history of paroxysmal atrial fibrillation (P < .
001; hazard ratio [HR] = 16.84), use of antiarrhythmic drugs before pacemaker
implant (P < .001; HR = 2.25), ventricular pacing mode (P = .003; HR = 1.98), age
(P = .005; HR = 1.03), and valvular heart disease (P = .008; HR = 2.05). For
patients with preimplant history of paroxysmal atrial fibrillation, independent
predictors were prolonged episodes of paroxysmal atrial fibrillation (P < .001; HR
= 2.56), long history of paroxysmal atrial fibrillation (P = .004; HR = 2.05),
ventricular pacing mode (P = .025; HR = 1.69), use of antiarrhythmic drugs before
pacemaker implant (P = .024; HR = 1.71), and age (P = .04; HR = 1.02). Actuarial
incidence of stroke was 3% at 1 year, 5% at 5 years, and 13% at 10 years.
Independent predictors for stroke were history of cerebrovascular disease (P < .
001; HR = 5.22), ventricular pacing mode (P = .008; HR = 2.61), and history of
paroxysmal atrial fibrillation (P = .037; HR = 2.81). CONCLUSIONS: Development of
chronic atrial fibrillation and stroke in paced patients with sick sinus syndrome
are strongly determined by clinical variables and secondarily by the pacing
modality. Ventricular pacing mode predicts chronic atrial fibrillation in patients
with preimplant paroxysmal atrial fibrillation but not in those without it.
AD - Department of Cardiology, Cleveland Clinic Foundation, OH 44195.
AN - 8353866
AU - Sgarbossa, E. B.
AU - Pinski, S. L.
AU - Maloney, J. D.
AU - Simmons, T. W.
AU - Wilkoff, B. L.
AU - Castle, L. W.
AU - Trohman, R. G.
DA - Sep
DO - 10.1161/01.cir.88.3.1045
DP - NLM
ET - 1993/09/01
IS - 3
J2 - Circulation
Aged
Cerebrovascular Disorders/*epidemiology
Chronic Disease
Female
Humans
Incidence
Male
Morbidity
Risk Factors
Sick Sinus Syndrome/epidemiology/*therapy
Time Factors
LA - eng
N1 - Sgarbossa, E B
Pinski, S L
Maloney, J D
Simmons, T W
Wilkoff, B L
Castle, L W
Trohman, R G
Journal Article
United States
Circulation. 1993 Sep;88(3):1045-53. doi: 10.1161/01.cir.88.3.1045.
PY - 1993
SN - 0009-7322 (Print)
0009-7322
SP - 1045-53
ST - Chronic atrial fibrillation and stroke in paced patients with sick sinus
syndrome. Relevance of clinical characteristics and pacing modalities
T2 - Circulation
TI - Chronic atrial fibrillation and stroke in paced patients with sick sinus
syndrome. Relevance of clinical characteristics and pacing modalities
VL - 88
ID - 2933
ER -
TY - JOUR
AB - Complications encountered during 351 selective coronary artery and coronary
artery bypass examinations performed by the Judkins technique are reviewed. The
over-all incidence of cardiac and peripheral vascular complications was 3.13 per
cent. The cardiac complications included four ventricular fibrillations and one
acute myocardial infarction. Peripheral vascular complications included three
femoral artery thromboses, two peripheral emboli, and one probable cerebral
embolus. There was one death. The incidence of cardiac complications was not
significantly different from that reported in the literature with the Sones
technique and local arterial complications were significantly lower than those
reported with the Sones technique. The causes of individual complications are
analyzed and measures to minimize these complications are described. The Judkins
technique is a simple, reliable, quick, and safe method of selective coronary
arteriography. The incidence of complications can be kept at an acceptably low
level by stringent observation of every minor detail of the technique.
AN - 1163427
AU - Shah, A.
AU - Gnoj, J.
AU - Fisher, V. J.
DA - Sep
DO - 10.1016/0002-8703(75)90325-7
DP - NLM
ET - 1975/09/01
IS - 3
KW - Adult
Aged
Angiography/*adverse effects/methods
Arteries/*injuries
Cardiac Catheterization/adverse effects
Catheterization/*adverse effects
Coronary Vessels/injuries
Female
Femoral Artery/injuries
Humans
Male
Middle Aged
Myocardial Infarction/*etiology
Thrombosis/etiology
Ventricular Fibrillation/*etiology
LA - eng
N1 - Shah, A
Gnoj, J
Fisher, V J
Journal Article
United States
Am Heart J. 1975 Sep;90(3):353-9. doi: 10.1016/0002-8703(75)90325-7.
PY - 1975
SN - 0002-8703 (Print)
0002-8703
SP - 353-9
ST - Complications of selective coronary arteriography by the Judkins technique
and their prevention
T2 - Am Heart J
TI - Complications of selective coronary arteriography by the Judkins technique
and their prevention
VL - 90
ID - 3033
ER -
TY - JOUR
AB - Subarachnoid hemorrhage (SAH) is a neurologic emergency associated with high
mortality rate. Polymorphic ventricular tachycardia (VT) is a rare arrhythmia. It
can occur in any setting of a long QT interval and bradycardia. This may result
from a cardiomyopathy (both ischemic and non-ischemic), acute coronary ischemia,
congenital long QT syndrome, electrolyte disturbances and cerebrovascular diseases.
We report a rare case of polymorphic VT of unclear etiology with a normal corrected
QT, likely secondary to SAH. Reports associating ventricular arrhythmias and SAH
have been described, yet the mechanism of this association remains unclear.
Previous observations of VT seen in patients with SAH suggest a relationship with
QT prolongation. The QT interval, however, remained normal in our patient,
suggesting an alternative and unknown mechanism for the polymorphic VT.
AD - Department of Medicine, SUNY Upstate Medical University, 50 Presidential
Plaza, Apt#1505, Syracuse, NY 13202, USA.
Department of Cardiovascular Medicine, SUNY Upstate Medical University, 750 East
Adams Street, Syracuse, NY 13210, USA.
Department of Medicine, SUNY Upstate Medical University, 750 East Adams Street,
Syracuse, NY 13210, USA.
SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA.
AN - 29118886
AU - Shah, S. P.
AU - Pitroda, P.
AU - Patel, K.
AU - Chandak, R.
AU - Ford, T.
C2 - PMC5667711
DA - Oct
DO - 10.14740/cr574w
DP - NLM
ET - 2017/11/10
IS - 5
J2 - Cardiology research
KW - Normal QTc
Polymorphic ventricular tachycardia
Subarachnoid hemorrhage
LA - eng
N1 - 1923-2837
Shah, Siddharth Paresh
Pitroda, Priyanka
Patel, Kinner
Chandak, Rahul
Ford, Timothy
Case Reports
Cardiol Res. 2017 Oct;8(5):232-235. doi: 10.14740/cr574w. Epub 2017 Oct 27.
PY - 2017
SN - 1923-2829 (Print)
1923-2829
SP - 232-235
ST - Polymorphic Ventricular Tachycardia Secondary to Subarachnoid Haemorrhage: A
Rare Occurrence in the Setting of Normal QTc
T2 - Cardiol Res
TI - Polymorphic Ventricular Tachycardia Secondary to Subarachnoid Haemorrhage: A
Rare Occurrence in the Setting of Normal QTc
VL - 8
ID - 3088
ER -
TY - JOUR
AB - "Lone" atrial fibrillation (AF) is generally used to refer to patients with
AF in the absence of structural heart disease. When the decision for oral
anticoagulation is discussed, "lone" AF refers to patients who do not have
established stroke risk factors. Imaging is often used to rule out structural heart
disease, e.g. coronary artery disease, peripheral vascular disease, mitral stenosis
or left ventricular (LV) dysfunction. Imaging of the heart has a central role in
establishing the "lone" aspect in patients with "lone"AF, similar to the
measurement of blood glucose and blood pressure: Patients with structural heart
disease, defined as e.g. reduced LV ejection fraction, clinical evidence for heart
failure, or evidence for coronary artery disease, will not be considered as
patients with "lone" AF. The search for these conditions requires some cardiac
imaging, often done by echocardiography and non-invasive tests for coronary artery
disease or ischemia. Increasingly, brain imaging is used to define the clinical
diagnosis of a stroke, thus also contributing to the detection of stroke risk
factors. Cerebral imaging in AF patients without competing causes for silent
strokes or microbleeds ("lone" AF, rather used in the context of anticoagulation,
i.e. clinical absence of structural heart disease) would allow to better understand
the contribution of AF to these brain lesions. The assumption that silent strokes
are likely drivers of cognitive dysfunction, and the fact that microbleeds put
patients at risk for intracerebral hemorrhage, illustrates the need to collect
information on brain imaging. In this review article, we summarize current data on
heart and brain imaging in patients with "lone" AF and discuss their clinical
implications for risk assessment and management of patients with "lone" AF.
AD - University of Birmingham Centre for Cardiovascular Sciences and SWBH NHS
trust, Birmingham, UK. shantsila@yandex.com.
AN - 25175092
AU - Shantsila, E.
AU - Haeusler, K. G.
AU - Fiebach, J. B.
AU - Breithardt, G.
AU - Kirchhof, P.
DO - 10.2174/1381612820666140825131221
DP - NLM
ET - 2014/09/02
IS - 5
J2 - Current pharmaceutical design
KW - Atrial Fibrillation/complications/*pathology
Atrial Remodeling
Brain/*pathology
Coronary Vessels/pathology
Electrocardiography
Humans
Mitral Valve/pathology
Risk Factors
Stroke/etiology/*pathology
LA - eng
N1 - 1873-4286
Shantsila, Eduard
Haeusler, Karl Georg
Fiebach, Jochen B
Breithardt, Gunter
Kirchhof, Paulus
Journal Article
Review
United Arab Emirates
Curr Pharm Des. 2015;21(5):613-21. doi: 10.2174/1381612820666140825131221.
PY - 2015
SN - 1381-6128
SP - 613-21
ST - The heart and brain imaging in lone atrial fibrillation - are we surprised?
T2 - Curr Pharm Des
TI - The heart and brain imaging in lone atrial fibrillation - are we surprised?
VL - 21
ID - 2433
ER -
TY - JOUR
AB - PURPOSE: Inappropriate administration of intravenous verapamil to patients
with wide QRS complex tachycardia due to ventricular tachycardia or atrial
fibrillation with Wolff-Parkinson-White syndrome occurs frequently because of
misdiagnosis, and may precipitate a cardiac arrest. We evaluated the safety and the
diagnostic and therapeutic utility of adenosine triphosphate administered to a
consecutive series of 34 patients during wide QRS complex tachycardia due to a
variety of mechanisms. PATIENTS AND METHODS: Patients who had a hemodynamically and
electrically stable, monomorphic, wide (greater than 120 msec) QRS complex
tachycardia induced during an invasive cardiac electrophysiologic test were
studied. Hemodynamic stability was defined by a systolic blood pressure greater
than 80 mm Hg and no clinical evidence of cerebral or myocardial ischemia.
Adenosine triphosphate, 20 mg, was administered as a rapid intravenous bolus via a
peripheral vein during wide QRS complex tachycardia. Five surface electrocardiogram
leads, at least three intracardiac electrograms, and blood pressure were monitored.
RESULTS: Ventricular tachycardia was present in 14 patients (mean age 50.6 +/- 19
years, cycle length 326 +/- 67 msec) and adenosine triphosphate terminated the
arrhythmia in one case. Ventricular tachycardia cycle length did not change. Among
10 patients with supraventricular tachycardia with mechanisms not involving the AV
node (average ventricular cycle length 346 +/- 82 msec), one case of ectopic atrial
tachycardia was terminated. The ventricular rate was transiently increased in
patients with Wolff-Parkinson-White syndrome and atrial fibrillation (average R-R
interval 351 +/- 84 msec in control and 317 +/- 82 msec after adenosine
triphosphate, p less than 0.001). Reentrant tachycardias involving the AV node
(cycle length 302 +/- 52 msec) terminated in seven of 10 patients. The drug was
well tolerated, and no patient developed hemodynamic compromise necessitating
cardioversion as a result of adenosine triphosphate. CONCLUSION: In the setting of
electrophysiology testing, adenosine triphosphate is a safe agent, even when
administered inappropriately during arrhythmias for which it is relatively
ineffective, such as ventricular tachycardia, and Wolff-Parkinson-White syndrome
with atrial fibrillation. It is an effective agent in terminating supraventricular
tachycardia involving the AV node. Tachycardia termination following adenosine
triphosphate, when used as a diagnostic test to indicate obligatory participation
of the AV node, had a sensitivity of 70%, specificity of 92%, and a positive
predictive accuracy of 85%. Thus, adenosine triphosphate also has diagnostic
utility, but should be used after the appropriate arrhythmia diagnosis has been
made based on the clinical history and analysis of the 12-lead electrocardiogram.
AD - Mercy General Hospital, Sacramento, California 95819.
AN - 2327421
AU - Sharma, A. D.
AU - Klein, G. J.
AU - Yee, R.
DA - Apr
DO - 10.1016/0002-9343(90)90486-w
DP - NLM
ET - 1990/04/01
IS - 4
KW - Adenosine Triphosphate/*administration & dosage
Adult
Electrophysiology
Heart Conduction System/physiology
Humans
Middle Aged
Safety
Tachycardia/diagnosis/*drug therapy
LA - eng
N1 - Sharma, A D
Klein, G J
Yee, R
Journal Article
United States
Am J Med. 1990 Apr;88(4):337-43. doi: 10.1016/0002-9343(90)90486-w.
PY - 1990
SN - 0002-9343 (Print)
0002-9343
SP - 337-43
ST - Intravenous adenosine triphosphate during wide QRS complex tachycardia:
safety, therapeutic efficacy, and diagnostic utility
T2 - Am J Med
TI - Intravenous adenosine triphosphate during wide QRS complex tachycardia:
safety, therapeutic efficacy, and diagnostic utility
VL - 88
ID - 2743
ER -
TY - JOUR
AB - Out-of-hospital ventricular fibrillation (OHVF) is the most common cause of
sudden cardiac death. Of 1,070 patients with OHVF who entered this study, 150 were
discharged alive. Of this group, 120 were free of anoxic brain damage. Of these
survivors, 67 (57%) had no previously demonstrated anginal symptoms. Treadmill
stress testing revealed painless ST depression in 76% of these neurologically
intact patients. Exercise ventriculography in a subset of 9 patients without angina
before OHVF and in 6 patients with typical anginal symptoms revealed marked left
ventricular dysfunction with ST depression in the absence of chest pain in all 15
patients. Sublingual nitroglycerin reversed this evidence of ischemia in the
asymptomatic patients. Patients were followed for 6 years after discharge. No
statistical difference in mortality could be demonstrated for patients who had
previous anginal symptoms vs those who did not, nor was age a predictor of
mortality. Women had the same risk of death as men at 2 years after OHVF, but a
significantly higher risk by year 6. Myocardial infarction associated with OHVF did
not predict lower mortality throughout the study.
AD - Cardiology Care Clinic, St. Joseph's Hospital, Hot Springs, Arkansas.
AN - 3358359
AU - Sharma, B.
AU - Wyeth, R. P.
DA - Apr 21
DO - 10.1016/0002-9149(88)90047-1
DP - NLM
ET - 1988/04/21
IS - 12
KW - Death, Sudden/*etiology
Electrocardiography
Exercise Test
Female
Follow-Up Studies
Humans
Male
Myocardial Infarction/complications/*mortality
Time Factors
Ventricular Fibrillation/etiology/*mortality/physiopathology
LA - eng
N1 - Sharma, B
Wyeth, R P
Journal Article
United States
Am J Cardiol. 1988 Apr 21;61(12):9F-15F. doi: 10.1016/0002-9149(88)90047-1.
PY - 1988
SN - 0002-9149 (Print)
0002-9149
SP - 9f-15f
ST - Six-year survival of patients with and without painless myocardial ischemia
and out-of-hospital ventricular fibrillation
T2 - Am J Cardiol
TI - Six-year survival of patients with and without painless myocardial ischemia
and out-of-hospital ventricular fibrillation
VL - 61
ID - 2848
ER -
TY - JOUR
AB - BACKGROUND: Left ventricular (LV) dyssynchrony is related to adverse outcomes
in systolic heart failure, but its prognostic importance in asymptomatic population
is not known. Our objective was to assess the prognostic implications of LV
mechanical dyssynchrony in a large multiethnic population before the occurrence of
global LV dysfunction. METHODS AND RESULTS: A total of 1392 participants in the
Multi-Ethnic Study of Atherosclerosis (MESA; mean age: 64.7 years; 46% were women)
with cardiac magnetic resonance imaging at baseline were followed for a median
duration of 8.3 years. Harmonic phase imaging analysis was used to derive systolic
circumferential strain. Greater standard deviation of time to peak systolic strain
(SD-TPS) indicates greater dyssynchrony. With SD-TPS as a continuous variable, Cox
proportional hazards analysis was used to assess hazards ratio after adjusting for
demographics, cardiovascular risk factors, LV mass-to-volume ratio, and ejection
fraction. Using the 75th percentile of SD-TPS as a cutoff, Kaplan-Meier analysis
was performed between 2 categorical groups for each gender. Higher values of
dyssynchrony in women predicted major adverse cardiovascular events, defined as
myocardial infarction, heart failure, stroke, and death (hazard ratio: 1.01 per 1-
ms increment in SD-TPS, P=0.015), hard coronary events (hazard ratio: 1.05 per 1-ms
increment in SD-TPS, P=0.026), and cerebrovascular events (hazard ratio: 1.03 per
1-ms increment in SD-TPS, P=0.013). In contrast, dyssynchrony in men was not
predictive of events. Kaplan-Meier analyses in women revealed increased event
occurrence in the higher dyssynchrony group, but this was not the case in men.
CONCLUSIONS: In an asymptomatic cohort, greater LV dyssynchrony determined by
cardiac magnetic resonance imaging predicts adverse cardiovascular outcome in women
but not in men. CLINICAL TRIAL REGISTRATION URL: http://clinicaltrials.gov. Unique
AD - Cardiology Division, Department of Medicine, Johns Hopkins Hospital,
Baltimore, Maryland (R.K.S., G.V., B.D.R., B.A.V., S.D., D.A.B., J.L.).
Department of Medicine, Mount Sinai Hospital, New York City, New York (V.F.).
Office of Biostatistics Research, National Heart, Lung, and Blood Institute,
Bethesda, Maryland (C.O.W.).
Department of Medicine, Vanderbilt University, Nashville, Tennessee (J.C.).
Cardiology Division, Department of Medicine, Johns Hopkins Hospital, Baltimore,
Maryland (R.K.S., G.V., B.D.R., B.A.V., S.D., D.A.B., J.L.) Department of
Radiology, Johns Hopkins Hospital, Baltimore, Maryland (D.A.B., J.L.) Radiology and
Imaging Sciences, National Institutes of Health (NIH), Bethesda, Maryland (D.A.B.).
Cardiology Division, Department of Medicine, Johns Hopkins Hospital, Baltimore,
Maryland (R.K.S., G.V., B.D.R., B.A.V., S.D., D.A.B., J.L.) Department of
Radiology, Johns Hopkins Hospital, Baltimore, Maryland (D.A.B., J.L.).
AN - 25092789
AU - Sharma, R. K.
AU - Volpe, G.
AU - Rosen, B. D.
AU - Ambale-Venkatesh, B.
AU - Donekal, S.
AU - Fernandes, V.
AU - Wu, C. O.
AU - Carr, J.
AU - Bluemke, D. A.
AU - Lima, J. A.
C2 - PMC4310386
DA - Aug 4
DO - 10.1161/jaha.114.000975
DP - NLM
ET - 2014/08/06
IS - 4
KW - Aged
Aged, 80 and over
Arrhythmias, Cardiac/diagnosis/physiopathology
*Asymptomatic Diseases
Cardiovascular Diseases/*mortality
Cohort Studies
Female
Heart Ventricles/*physiopathology
Humans
Male
Middle Aged
Prognosis
Prospective Studies
Sex Factors
Stroke/epidemiology
Ventricular Dysfunction, Left/diagnosis/*physiopathology
cardiac magnetic resonance imaging
cardiovascular events
left ventricular dyssynchrony
LA - eng
N1 - 2047-9980
Sharma, Ravi K
Volpe, Gustavo
Rosen, Boaz D
Ambale-Venkatesh, Bharat
Donekal, Sirisha
Fernandes, Veronica
Wu, Colin O
Carr, Jeffrey
Bluemke, David A
Lima, João A C
N01-HC95168/HC/NHLBI NIH HHS/United States
Journal Article
J Am Heart Assoc. 2014 Aug 4;3(4):e000975. doi: 10.1161/JAHA.114.000975.
PY - 2014
SN - 2047-9980
ST - Prognostic implications of left ventricular dyssynchrony for major adverse
cardiovascular events in asymptomatic women and men: the Multi-Ethnic Study of
Atherosclerosis
TI - Prognostic implications of left ventricular dyssynchrony for major adverse
cardiovascular events in asymptomatic women and men: the Multi-Ethnic Study of
Atherosclerosis
VL - 3
ID - 2597
ER -
TY - JOUR
AB - BACKGROUND: Ischemia-reperfusion (I/R) injury may influence graft function
after transplantation. Erythropoietin (EPO) attenuates I/R injury in various animal
organs such as intestine, brain, and kidney. OBJECTIVE: To evaluate the effects of
pretreatment with recombinant human EPO (rhEPO) on I/R-induced heart injury.
MATERIALS AND METHODS: A rat model of I/R injury was established by ligating the
left descending coronary artery for 30 minutes, followed by reperfusion for 4
hours. Fifty Sprague-Dawley rats were divided into 5 groups: sham operation; I/R;
I/R+rhEPO, 100 U/kg; I/R+rhEPO, 1000 U/kg; and I/R+rhEPO, 5000 U/kg.
Electrocardiograms were assessed continuously to note arrhythmia caused by
reperfusion. Serum concentrations of interleukin (IL)-6 and IL-8, and tumor
necrosis factor-alpha were measured at 2 and 4 hours after reperfusion. RESULTS:
The rhEPO-treated animals exhibited dosage-dependent significant reduction in the
incidence of ventricular arrhythmia caused by reperfusion, and markedly decreased
serum concentrations of IL-6, IL-8, and tumor necrosis factor-alpha (P < .05)
compared with the I/R group (P < .05). CONCLUSION: The rhEPO attenuates myocardial
I/R injury in rats, at least in part related to inhibition of the system
inflammatory response.
AD - Department of Cardio-thoracic Surgery, Jinling Hospital, Clinical Medicine
School, Nanjing University, Nanjing, China.
AN - 20620481
AU - Shen, Y.
AU - Wang, Y.
AU - Li, D.
AU - Wang, C.
AU - Xu, B.
AU - Dong, G.
AU - Huang, H.
AU - Jing, H.
DA - Jun
DO - 10.1016/j.transproceed.2009.11.050
DP - NLM
ET - 2010/07/14
IS - 5
J2 - Transplantation proceedings
KW - Animals
Erythropoietin/*pharmacology
Humans
Inflammation/*prevention & control
Interleukin-6/blood
Interleukin-8/blood
Myocardial Ischemia/*prevention & control
Myocardial Reperfusion Injury/epidemiology/pathology/*prevention & control
Rats
Rats, Sprague-Dawley
Recombinant Proteins
Reperfusion Injury/*prevention & control
Tumor Necrosis Factor-alpha/blood
LA - eng
N1 - 1873-2623
Shen, Y
Wang, Y
Li, D
Wang, C
Xu, B
Dong, G
Huang, H
Jing, H
Journal Article
United States
Transplant Proc. 2010 Jun;42(5):1595-7. doi: 10.1016/j.transproceed.2009.11.050.
PY - 2010
SN - 0041-1345
SP - 1595-7
ST - Recombinant human erythropoietin pretreatment attenuates heart ischemia-
reperfusion injury in rats by suppressing the systemic inflammatory response
T2 - Transplant Proc
TI - Recombinant human erythropoietin pretreatment attenuates heart ischemia-
reperfusion injury in rats by suppressing the systemic inflammatory response
VL - 42
ID - 3101
ER -
TY - JOUR
AB - BACKGROUND: Percutaneous mechanical circulatory support devices (pMCSDs) are
increasingly used on the assumption (but without solid proof) that their use will
improve prognosis. A meta-analysis was undertaken according to the PRISMA
guidelines to evaluate the benefits of pMCSDs in patients undergoing high-risk
percutaneous coronary intervention (hr-PCI). METHODS: We searched PubMed, EMbase,
Cochrane Library, Clinical Trial.gov, and other databases to identify eligible
studies. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated
for 30-day and 6-month all-cause mortality rates, reinfarction, and other adverse
events using a random effect model. RESULTS: Sixteen randomized controlled trials
(RCTs) were included in this study. In the pooled analysis, intra-aortic balloon
pump (IABP) was not associated with a decrease in 30-day and 6-month all-cause
mortality (RR 1.01 95% CI 0.61-1.66; RR 0.88 95% CI 0.66-1.17), reinfarction (RR
0.89 95% CI 0.69-1.14), stroke/transient ischemic attack (TIA) (RR 1.75 95% CI
0.47-6.42), heart failure (HF) (RR 0.54 95% CI 0.11-2.66), repeat revascularization
(RR 0.73 95% CI 0.25-2.10), embolization (RR 3.00 95% CI 0.13-71.61), or arrhythmia
(RR 2.81 95% CI 0.30-26.11). Compared with IABP, left ventricular assist devices
(LVADs) were not associated with a decrease in 30-day and 6-month all-cause
mortality (RR 0.96 95% CI 0.71-1.29; RR 1.23 95% CI 0.88-1.72), reinfarction (RR
0.98 95% CI 0.68-1.42), stroke/TIA (RR 0.45 95% CI 0.1-1.95), acute kidney injury
(AKI) (RR 0.83 95% CI 0.38-1.80), or arrhythmia (RR 1.52 95% CI 0.71-3.27), but
LVADs were associated with a decrease in repeat revascularization (RR 0.26 95% CI
0.08-0.83). However, LVADs significantly increased the risk of bleeding compared
with IABP (RR 2.85 95% CI 1.72-4.73). CONCLUSIONS: Neither LVADs nor IABP improves
short or long-term survival in hr-PCI patients. LVADs are more likely to reduce
repeat revascularization after PCI, but to increase the risk of bleeding events
than IABP.
AD - Department of Cardiology, the Sixth People's Hospital of Chengdu, Chengdu.
Department of Cardiology, the First Affiliated Hospital of Chongqing Medical
University, Chongqing, China.
AN - 31517843
AU - Shi, W.
AU - Wang, W.
AU - Wang, K.
AU - Huang, W.
C2 - PMC6750338
DA - Sep
DO - 10.1097/md.0000000000017107
DP - NLM
ET - 2019/09/14
IS - 37
J2 - Medicine
Embolization, Therapeutic/methods
Heart-Assist Devices/*standards/statistics & numerical data
Humans
Intra-Aortic Balloon Pumping/methods/*standards/statistics & numerical data
Percutaneous Coronary Intervention/adverse effects/*methods/standards
Randomized Controlled Trials as Topic/statistics & numerical data
Risk Factors
Stroke/therapy
Treatment Outcome
LA - eng
N1 - 1536-5964
Shi, Wenhai
Wang, Wuwan
Wang, Kechun
Huang, Wei
Journal Article
Meta-Analysis
Systematic Review
Medicine (Baltimore). 2019 Sep;98(37):e17107. doi: 10.1097/MD.0000000000017107.
PY - 2019
SN - 0025-7974 (Print)
0025-7974
SP - e17107
ST - Percutaneous mechanical circulatory support devices in high-risk patients
undergoing percutaneous coronary intervention: A meta-analysis of randomized trials
TI - Percutaneous mechanical circulatory support devices in high-risk patients
undergoing percutaneous coronary intervention: A meta-analysis of randomized trials
VL - 98
ID - 2294
ER -
TY - JOUR
AN - 11183886
AU - Shibolet, O.
AU - Amit, G.
DA - Nov 9
DP - NLM
ET - 2001/02/24
IS - 19
KW - Arrhythmias, Cardiac/*therapy
Equipment Design
Equipment Failure
Humans
Infections/etiology
Stroke/epidemiology
LA - eng
N1 - Shibolet, O
Amit, G
Comment
Journal Article
United States
N Engl J Med. 2000 Nov 9;343(19):1418.
PY - 2000
SN - 0028-4793 (Print)
0028-4793
SP - 1418
ST - Effects of physiologic pacing versus ventricular pacing
T2 - N Engl J Med
TI - Effects of physiologic pacing versus ventricular pacing
VL - 343
ID - 2776
ER -
TY - JOUR
AB - BACKGROUND: Substantial infective endocarditis (IE)-related morbidity and
mortality may occur even after successful treatment. However, no previous study has
explored long-term hard end points (ie, stroke, myocardial infarction, heart
failure, cardiovascular death) in addition to all-cause mortality in IE survivors.
METHODS AND RESULTS: A nationwide population-based cohort study was conducted among
IE survivors identified with the use of the Taiwan National Health Insurance
Research Database during 2000 to 2009. IE survivors were defined as those who
survived after discharge from first hospitalization with a diagnosis of IE. A total
of 10 116 IE survivors were identified. IE survivors were matched to control
subjects without IE at a 1:1 ratio through the use of propensity scores. The
primary outcomes were stroke, myocardial infarction, readmission for heart failure,
and sudden cardiac death or ventricular arrhythmia. The secondary outcomes were
repeat IE and all-cause mortality. Compared with the matched cohort, IE survivors
had higher risks of ischemic stroke (adjusted hazard ratio [aHR], 1.59; 95%
confidence interval [CI], 1.40-1.80), hemorrhagic stroke (aHR, 2.37; 95% CI, 1.90-
2.96), myocardial infarction (aHR, 1.44; 95% CI, 1.17-1.79), readmission for heart
failure (aHR, 2.24; 95% CI, 2.05-2.43), sudden death or ventricular arrhythmia
(aHR, 1.69; 95% CI, 1.44-1.98), and all-cause death (aHR, 2.27; 95% CI, 2.14-2.40).
Risk factors for repeat IE were older age, male sex, drug abuse, and valvular
replacement after an initial episode of IE. CONCLUSION: Despite treatment, the risk
of long-term major adverse cardiac events was substantially increased in IE
survivors.
AD - From the School of Medicine (C-J.S., H.C., Y-J.L., S.-C.K., S.-Y.L., D.-C.T.,
C.-Y.Y., W.-C.Y., S.-M.O., Y.-T.C.) and Institute of Clinical Medicine (S.-M.O.),
National Yang-Ming University, Taipei, Taiwan; Department of Medicine, Taipei
Veterans General Hospital, Yuanshan Branch, Yilan, Taiwan (C.-J.S.); Division of
Respiratory Medicine, Department of Chest (H.C.), and Division of Nephrology,
Department of Medicine (Y.-T.C.), Taipei City Hospital, Heping Fuyou Branch,
Taipei, Taiwan; School of Medicine and Department of Anesthesiology, Wan Fang
Hospital, Taipei Medical University, Taipei, Taiwan (P.-W.C.); Department of
Neurology, Neurological Institute (Y.-J.L.), Division of Infectious Diseases (S.-
C.K.), and Division of Nephrology, Department of Medicine (S.-Y.L., D.-C.T., C.-
Y.Y., W.-C.Y., S.-M.O.), Taipei Veterans General Hospital, Taipei, Taiwan; and
National Institute of Infectious Diseases and Vaccinology, National Health Research
Institutes, Miaoli County, Taiwan (S.-C.K.).
From the School of Medicine (C-J.S., H.C., Y-J.L., S.-C.K., S.-Y.L., D.-C.T., C.-
Y.Y., W.-C.Y., S.-M.O., Y.-T.C.) and Institute of Clinical Medicine (S.-M.O.),
National Yang-Ming University, Taipei, Taiwan; Department of Medicine, Taipei
Veterans General Hospital, Yuanshan Branch, Yilan, Taiwan (C.-J.S.); Division of
Respiratory Medicine, Department of Chest (H.C.), and Division of Nephrology,
Department of Medicine (Y.-T.C.), Taipei City Hospital, Heping Fuyou Branch,
Taipei, Taiwan; School of Medicine and Department of Anesthesiology, Wan Fang
Hospital, Taipei Medical University, Taipei, Taiwan (P.-W.C.); Department of
Neurology, Neurological Institute (Y.-J.L.), Division of Infectious Diseases (S.-
C.K.), and Division of Nephrology, Department of Medicine (S.-Y.L., D.-C.T., C.-
Y.Y., W.-C.Y., S.-M.O.), Taipei Veterans General Hospital, Taipei, Taiwan; and
National Institute of Infectious Diseases and Vaccinology, National Health Research
Institutes, Miaoli County, Taiwan (S.-C.K.). ytchen0117@gmail.com
okokyytt@gmail.com.
AN - 25223982
AU - Shih, C. J.
AU - Chu, H.
AU - Chao, P. W.
AU - Lee, Y. J.
AU - Kuo, S. C.
AU - Li, S. Y.
AU - Tarng, D. C.
AU - Yang, C. Y.
AU - Yang, W. C.
AU - Ou, S. M.
AU - Chen, Y. T.
DA - Nov 4
DP - NLM
ET - 2014/09/17
IS - 19
J2 - Circulation
KW - Adult
Aged
Arrhythmias, Cardiac/*mortality
Endocarditis/*mortality
Female
Humans
Male
Middle Aged
Morbidity
Myocardial Infarction/*mortality
Risk Factors
Stroke/mortality
Survivors/*statistics & numerical data
Time Factors
endocarditis
epidemiology
heart failure
mortality
myocardial infarction
stroke
LA - eng
N1 - 1524-4539
Shih, Chia-Jen
Chu, Hsi
Chao, Pei-Wen
Lee, Yi-Jung
Kuo, Shu-Chen
Li, Szu-Yuan
Tarng, Der-Cherng
Yang, Chih-Yu
Yang, Wu-Chang
Ou, Shuo-Ming
Chen, Yung-Tai
Journal Article
United States
Epub 2014 Sep 15.
PY - 2014
SN - 0009-7322
SP - 1684-91
ST - Long-term clinical outcome of major adverse cardiac events in survivors of
infective endocarditis: a nationwide population-based study
T2 - Circulation
TI - Long-term clinical outcome of major adverse cardiac events in survivors of
infective endocarditis: a nationwide population-based study
VL - 130
ID - 2586
ER -
TY - JOUR
AB - BACKGROUND: The objective of this study was to investigate myocardial
deformation of the left atrium (LA) assessed by two-dimensional speckle tracking
echocardiography in patients with permanent atrial fibrillation (AF) and its value
for risk stratification for stroke. METHODS: We recruited 66 consecutive patients
with permanent AF who were referred to our echocardiography laboratory for
evaluation. These patients were divided into two groups according to the presence
of previous stroke or not. RESULTS: Peak positive longitudinal strain (LASp) during
atrial filling, peak strain rate in the reservoir phase of LA (LASRr), and peak
strain rate in the conduit phase (LASRc) were identified from LA strain and strain
rate curves. The ratio of peak early filling velocity (E) of mitral inflow to early
diastolic annulus velocity (E') of the medial annulus (E/E') was calculated. LASp
(10.44% ± 4.2% vs. 15.69% ± 5.1%, P < .001), LASRr (1.09 ± 0.27 1/s vs. 1.37 ± 0.32
1/s, P = .001), and LASRc (-1.28 ± 0.38 1/s vs. -1.62 ± 0.43 1/s, P = .002) were
significantly lower in patients with AF with stroke than those without stroke. By
multivariate analysis controlling for age, LA volume index, and left ventricular
ejection fraction, LASp (OR 0.787, 95% CI, 0.639-0.968, P = .023) and LASRr (OR
0.019, 95% CI, 0.001-0.585, P = .023) were independently associated with stroke but
not LASRc, E', and E/E' ratio. CONCLUSION: Decreased LASp and LASRr were
independently associated with stroke in patients with permanent AF.
AD - Tainan Hospital Sin-Hua Branch, Tainan, Taiwan.
AN - 21353469
AU - Shih, J. Y.
AU - Tsai, W. C.
AU - Huang, Y. Y.
AU - Liu, Y. W.
AU - Lin, C. C.
AU - Huang, Y. S.
AU - Tsai, L. M.
AU - Lin, L. J.
DA - May
DO - 10.1016/j.echo.2011.01.016
DP - NLM
ET - 2011/03/01
IS - 5
KW - Aged
Atrial Fibrillation/diagnosis/diagnostic imaging/*pathology
Diastole
Female
Heart Atria/diagnostic imaging/*pathology
Heart Rate
Humans
Male
Odds Ratio
Prognosis
ROC Curve
Risk Assessment
Stroke/diagnosis/diagnostic imaging/*pathology
Stroke Volume
Ultrasonography
LA - eng
N1 - 1097-6795
Shih, Jhih-Yuan
Tsai, Wei-Chuan
Huang, Yao-Yi
Liu, Yen-Wen
Lin, Chih-Chan
Huang, Yu-Shan
Tsai, Liang-Miin
Lin, Li-Jen
Comment
Journal Article
United States
J Am Soc Echocardiogr. 2011 May;24(5):513-9. doi: 10.1016/j.echo.2011.01.016. Epub
2011 Feb 24.
PY - 2011
SN - 0894-7317
SP - 513-9
ST - Association of decreased left atrial strain and strain rate with stroke in
chronic atrial fibrillation
TI - Association of decreased left atrial strain and strain rate with stroke in
chronic atrial fibrillation
VL - 24
ID - 2535
ER -
TY - JOUR
AB - Maximal left atrial volume (LAVmax) has been suggested to be an important
indicator of left ventricular (LV) diastolic function and a prognosticator in
patients with hypertrophic cardiomyopathy (HCM). However, LAVmax can be influenced
by LV longitudinal systolic function, which causes systolic descent of the mitral
plane. We investigated the prognostic role of LAVmin in patients with HCM and
tested if LAVmin is better than LAVmax in predicting clinical outcome in these
patients. A total of 167 consecutive patients with HCM were enrolled (age = 64.7 ±
13.5 years, male: female = 120:47). Clinical parameters and conventional
echocardiographic measurement including tissue Doppler measurement were evaluated.
Left atrial maximal and minimal volumes were measured just before mitral valve
opening and at mitral valve closure respectively using the biplane disk method. The
relationship between LAVmin and the clinical outcome of hospitalization for heart
failure (HF), stroke or all-cause mortality was evaluated. During a median follow-
up of 25.0 ± 17.8 months, the primary end point of HF hospitalization, stroke or
death occurred in 35 patients (21%). Indexed LAVmin was predictive of HF, stroke or
death after adjustment for age, diabetes, hypertension, atrial fibrillation, LV
ejection fraction, and E/e'in a multivariate analysis (P = 0.001). The model
including indexed LAVmin was superior to the model including indexed LAVmax in
predicting a worse outcome in patients with HCM (P = 0.02). In conclusion, LAVmin
was independently associated with increased risk of HF, stroke, or mortality in
patients with HCM and was superior to LAVmax in predicting clinical outcome in this
population.
AD - Division of Cardiology, Department of Internal Medicine, Inha University
Hospital.
AN - 30158386
AU - Shin, S. H.
AU - Jang, J. H.
AU - Baek, Y. S.
AU - Kwon, S. W.
AU - Park, S. D.
AU - Woo, S. I.
AU - Kim, D. H.
AU - Kwan, J.
DA - Sep 26
DO - 10.1536/ihj.17-606
DP - NLM
ET - 2018/08/31
IS - 5
KW - Aged
Atrial Fibrillation/physiopathology
Cardiomyopathy, Hypertrophic/complications/diagnostic
imaging/*mortality/physiopathology
Echocardiography, Doppler/methods
Female
Heart Atria/*diagnostic imaging/*physiopathology
Humans
Male
Middle Aged
Prognosis
Minimal LA volume
LA - eng
N1 - 1349-3299
Shin, Sung-Hee
Jang, Ji-Hoon
Baek, Yong-Soo
Kwon, Sung-Woo
Park, Sang-Don
Woo, Seong-Ill
Kim, Dae-Hyeok
Kwan, Jun
Clinical Trial
Journal Article
Japan
Int Heart J. 2018 Sep 26;59(5):991-995. doi: 10.1536/ihj.17-606. Epub 2018 Aug 29.
PY - 2018
SN - 1349-2365
SP - 991-995
ST - Prognostic Impact of Left Atrial Minimal Volume on Clinical Outcome in
Patients with Non-Obstructive Hypertrophic Cardiomyopathy
T2 - Int Heart J
TI - Prognostic Impact of Left Atrial Minimal Volume on Clinical Outcome in
Patients with Non-Obstructive Hypertrophic Cardiomyopathy
VL - 59
ID - 2802
ER -
TY - JOUR
AB - Clinical and morphological studies were carried out in 194 patients who died
in the acute period of ischemic brain stroke. Disorders of the heart rhythm were
found to play the leading part in the origin of cardiogenic embolisms of cerebral
vessels. It has been recorded that left atrial thrombus formation was prevalent in
heart rhythm disorders whereas left ventricular was prevalent in lack of those
disorders. In different heart diseases complicated by atrial fibrillation and
cerebral thromboembolism, the one-third of cases did not show any heart thromboses.
The content of embolisms in cerebral arteries corresponded to the material of their
source, whereas the site was specified by mechanical obstruction, with no changes
in the vascular wall. It has been disclosed that in the majority of cases, stable
embolism precipitates white infarction or white infarction with the hemorrhagic
component whereas embolus lysis is responsible for hemorrhagic infarction and (or)
a transitory ischemic attack. The clinical manifestations of hemorrhagic infarction
differ from white infarction in less gravity and regression of the neurological
symptomatology.
AN - 1319649
AU - Shmushkevich, L. S.
AU - Nadezhdina, M. V.
DP - NLM
ET - 1992/01/01
IS - 1
J2 - Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia :
1952)
KW - Acute Disease
Adolescent
Adult
Aged
Cerebral Infarction/*etiology/pathology
Female
Heart Atria
Heart Ventricles
Humans
Intracranial Embolism and Thrombosis/*etiology/pathology
Ischemic Attack, Transient/*etiology/pathology
Male
Middle Aged
Thrombosis/*complications
LA - rus
N1 - Shmushkevich, L S
Nadezhdina, M V
English Abstract
Journal Article
Russia (Federation)
Zh Nevropatol Psikhiatr Im S S Korsakova. 1992;92(1):48-53.
OP - Kliniko-morfologicheskie osobennosti kardiogennykh nebakterial'nykh émboliĭ
sosudov golovnogo mozga.
PY - 1992
SN - 0044-4588 (Print)
0044-4588
SP - 48-53
ST - [Clinico-morphological characteristics of cardiogenic non-bacterial cerebral
embolism]
T2 - Zh Nevropatol Psikhiatr Im S S Korsakova
TI - [Clinico-morphological characteristics of cardiogenic non-bacterial cerebral
embolism]
VL - 92
ID - 2713
ER -
TY - JOUR
AB - BACKGROUND AND OBJECTIVES: To assess thromboembolic and bleeding risks in
patients with heart failure (HF) and atrial fibrillation (AF) according to HF type.
METHODS: We analyzed 6170 AF patients from the Prevention of thromboembolic events
- European Registry in Atrial Fibrillation (PREFER in AF), and categorized patients
into: HF with reduced left-ventricular ejection fraction (HFrEF; LVEF < 40%); mid-
range EF (HFmrEF; LVEF: 40-49%); lower preserved EF (HFLpEF; LVEF: 50-60%), higher
preserved EF (HFHpEF; LVEF > 60%), and no HF. Outcomes were ischemic stroke, major
adverse cardiovascular and cerebral events (MACCE) and major bleeding occurring
within 1-year. RESULTS: The annual incidence of stroke was linearly and inversely
related to LVEF, increasing by 0.054% per each 1% of LVEF decrease (95% CI: 0.013%-
0.096%; p = 0.031). Patients with HFHpEF had the highest CHA(2)DS(2)-VASc score,
but significantly lower stroke incidence than other HF groups (0.65%, compared to
HFLpEF 1.30%; HFmrEF 1.71%; HFrEF 1.75%; trend p = 0.014). The incidence of MACCE
was also lower in HFHpEF (2.0%) compared to other HF groups (range: 3.8-4.4%;
p = 0.001). Age, HF type, and NYHA class were independent predictors of
thromboembolic events. Conversely, major bleeding did not significantly differ
between groups (p = 0.168). CONCLUSION: Our study in predominantly anticoagulated
patients with AF shows that, reduction in LVEF is associated with higher
thromboembolic, but not higher bleeding risk. HFHpEF is a distinct and puzzling
group, featuring the highest CHA(2)DS(2)-VASc score but the lowest residual risk of
thromboembolic events, which warrants further investigation.
AD - Department of Cardiology, Medical University of Vienna, Vienna, Austria; 1st
Department of Cardiology, Poznan University of Medical Sciences, Poland. Electronic
address: jolanta.siller-matula@meduniwien.ac.at.
Institute of Informatics, Academy of Sciences of Czech Republic, Prague, Czech
Republic.
Department of Cardiovascular Sciences, Campus Bio-Medico University of Rome, Italy.
Daiichi Sankyo Europe, Munich, Germany.
Institute of Cardiovascular Sciences, University of Birmingham and SWBH and UHB NHS
Trusts, Birmingham, UK; AFNET, Münster, Germany.
1st Department of Cardiology, Poznan University of Medical Sciences, Poland.
3rd Medical Department, Cardiology and Intensive Care Medicine, Wilhelminen
Hospital, and Sigmund Freud University, Medical School, Vienna, Austria.
Emeritus Professor of Cardiology, Amsterdam, The Netherlands.
Department of Cardiology, Medical University of Vienna, Vienna, Austria.
G. d'Annunzio University of Chieti and Center of Excellence on Aging, CeSI-Met,
Italy.
Department for General and Interventional Cardiology, University Heart Center
Hamburg, Hamburg, Germany; German Center for Cardiovascular Research (DZHK) partner
site Hamburg/Kiel/Lübeck, Hamburg, Germany.
Clinic for Cardiology and Pneumology, University Medical Center Göttingen,
Göttingen, Germany; German Center for Cardiovascular Research, partner site,
Göttingen, Germany.
Institute of Cardiovascular Sciences, University of Birmingham and SWBH and UHB NHS
Trusts, Birmingham, UK.
Department of Cardiology, University Hospital Nancy, France.
3rd Medical Department, Cardiology and Intensive Care Medicine, Wilhelminen
Hospital, Vienna, Austria.
G. d'Annunzio University of Chieti and Center of Excellence on Aging, CeSI-Met,
Italy. Electronic address: rdecater@unich.it.
AN - 29706429
AU - Siller-Matula, J. M.
AU - Pecen, L.
AU - Patti, G.
AU - Lucerna, M.
AU - Kirchhof, P.
AU - Lesiak, M.
AU - Huber, K.
AU - Verheugt, F. W. A.
AU - Lang, I. M.
AU - Renda, G.
AU - Schnabel, R. B.
AU - Wachter, R.
AU - Kotecha, D.
AU - Sellal, J. M.
AU - Rohla, M.
AU - Ricci, F.
AU - De Caterina, R.
DA - Aug 15
DO - 10.1016/j.ijcard.2018.04.093
DP - NLM
ET - 2018/05/01
KW - Aged
Anticoagulants/adverse effects/therapeutic use
Atrial Fibrillation/*diagnosis/drug therapy/*epidemiology
Cohort Studies
Europe/epidemiology
Female
Follow-Up Studies
Heart Failure/*diagnosis/drug therapy/*epidemiology
Hemorrhage/chemically induced/diagnosis/epidemiology
Humans
Male
Prospective Studies
Registries
Risk Factors
Stroke/diagnosis/epidemiology
Stroke Volume/drug effects/physiology
Thromboembolism/*diagnosis/drug therapy/*epidemiology
Atrial fibrillation
Bleeding
Ejection fraction
Heart failure
Stroke
LA - eng
N1 - 1874-1754
Siller-Matula, Jolanta M
Pecen, Ladislav
Patti, Giuseppe
Lucerna, Markus
Kirchhof, Paulus
Lesiak, Maciej
Huber, Kurt
Verheugt, Freek W A
Lang, Irene M
Renda, Giulia
Schnabel, Renate B
Wachter, Rolf
Kotecha, Dipak
Sellal, Jean-Marc
Rohla, Miklos
Ricci, Fabrizio
De Caterina, Raffaele
TEAM in AF group
CDF-2015-08-074/Department of Health/United Kingdom
Journal Article
Netherlands
Int J Cardiol. 2018 Aug 15;265:141-147. doi: 10.1016/j.ijcard.2018.04.093. Epub
2018 Apr 22.
PY - 2018
SN - 0167-5273
SP - 141-147
ST - Heart failure subtypes and thromboembolic risk in patients with atrial
fibrillation: The PREFER in AF - HF substudy
T2 - Int J Cardiol
TI - Heart failure subtypes and thromboembolic risk in patients with atrial
fibrillation: The PREFER in AF - HF substudy
VL - 265
ID - 2352
ER -
TY - JOUR
AB - Atrial fibrillation, which is associated with a worsening of congestive heart
failure symptoms, an increased rate of stoke, and increased mortality, is still
difficult to treat. New therapies must not only increase effectiveness, but also
have to have an improved safety profile, in order to avoid sodium channel block in
the ventricle of older patients with atrial fibrillation, and also prevent
electrical and morphological remodeling. Dronedarone is less effective compared to
amiodarone, but has a better side effect profile which leads to fewer
discontinuations of treatment. The atrial ion channels are specifically blocked by
a number of prospective antiarrhythmic substances. The most advanced is the testing
of vernakalant (RSD1235), which primarily suppresses the I(Kur) current. Ranolazine
is a new antianginal substance which influences the atrial ion channels and leads
to a significant reduction of atrial and more specifically ventricular
tachyarrhythmias. A number of other drugs are in development. They will lead to a
better understanding of which form of atrial fibrillation can be best treated with
which antiarrhythmic agent.
AD - Kardiopulmonales Zentrum, Klinikum Coburg, Ketschendorferstr. 33, 96450,
Coburg, Deutschland. simon.helge@gmail.com
AN - 21107985
AU - Simon, H.
AU - Simon Demel, K.
AU - Ritscher, G.
AU - Turschner, O.
AU - Brachmann, J.
DA - Dec
DO - 10.1007/s00399-010-0093-y
DP - NLM
ET - 2010/11/26
IS - 4
J2 - Herzschrittmachertherapie & Elektrophysiologie
KW - Acetanilides/adverse effects/therapeutic use
Aged
Amiodarone/adverse effects/analogs & derivatives/therapeutic use
Animals
Anisoles/adverse effects/therapeutic use
Dronedarone
Drug-Related Side Effects and Adverse Reactions
Drugs, Investigational/adverse effects/therapeutic use
Heart Atria/drug effects
Heart Ventricles/drug effects
Humans
Piperazines/adverse effects/therapeutic use
Potassium Channels/drug effects
Pyrrolidines/adverse effects/therapeutic use
Ranolazine
Sodium Channels/drug effects
LA - ger
N1 - 1435-1544
Simon, H
Simon Demel, K
Ritscher, G
Turschner, O
Brachmann, J
Comparative Study
Journal Article
Review
Germany
Herzschrittmacherther Elektrophysiol. 2010 Dec;21(4):212-6. doi: 10.1007/s00399-
010-0093-y.
OP - Neue Entwicklungen in der antiarrhythmischen Therapie des Vorhofflimmerns.
PY - 2010
SN - 0938-7412
SP - 212-6
ST - [New developments in the antiarrhythmic therapy of atrial fibrillation]
T2 - Herzschrittmacherther Elektrophysiol
TI - [New developments in the antiarrhythmic therapy of atrial fibrillation]
VL - 21
ID - 2580
ER -
TY - JOUR
AB - OBJECTIVE: To investigate the clinical effectiveness and cost-effectiveness
of transthoracic echocardiography (TTE) in all patients who are newly diagnosed
with atrial fibrillation (AF). DESIGN: Narrative synthesis reviews were conducted
on the prognostic and diagnostic accuracy of TTE for, and prevalence of,
pathologies in patients with AF. Databases were searched from inception. MEDLINE
searches were conducted from March to August 2010, and reference lists of articles
checked. There were 44 diagnostic accuracy studies, five prognostic studies, and 16
prevalence studies accepted into the review. Given the complexity of the many
pathologies identified by TTE, the variety of potential changes to clinical
management, and paucity of data, the model focused on changes to oral
anticoagulation (OAC). The mathematical model assessed the cost-effectiveness of
TTE for patients with AF who were not routinely given OAC, assuming, if left atrial
abnormality was detected, that the higher risk of stroke warranted OAC; this meant
that patients with a CHADS2 (cardiac failure, hypertension, age, diabetes, stroke
doubled) score of 0 [dabigatran etexilate (Pradaxa, Boehringer
Ingelheim)/rivaroxaban (Xarelto, Bayer Schering)] or 0/1 (warfarin) were included.
A simplified approach evaluated the additional quality-adjusted life-years (QALYs)
required in order for TTE to be perceived as cost-effective at a threshold of
£20,000 per QALY. SETTING: Transthoracic echocardiography is usually performed in
cardiology clinics but may be used in primary or non-specialist secondary care.
PARTICIPANTS: Patients with newly diagnosed AF. INTERVENTION: Transthoracic
echocardiography. MAIN OUTCOME MEASURES: Prognosis, diagnostic sensitivity or
specificity of TTE, prevalence of pathologies in patients with AF, cost-
effectiveness and QALYs. RESULTS: Prognostic studies indicated that TTE-diagnosed
left ventricular dysfunction, increased left atrial diameter and valvular
abnormality were significantly associated with an increased risk of stroke,
mortality or thromboembolism. There was a high prevalence (around 25-30%) of
ischaemic heart disease, valvular heart disease and heart failure in patients with
AF. Diagnostic accuracy of TTE was high, with most pathologies having specificity
of ≥ 0.8 and sensitivity of ≥ 0.6. The mathematical model predicted that when the
CHADS2 tool is used the addition of TTE in identifying patients with left atrial
abnormality appears to be cost-effective for informing some OAC decisions. In the
simplified approach a threshold of 0.0033 was required for a TTE to be cost-
effective. CONCLUSIONS: When CHADS2 was used, the addition of TTE in identifying
patients with left atrial abnormality was cost-effective for informing some OAC
decisions. A simple analysis indicates that the number of QALYs required for TTE to
be cost-effective is small, and that if benefits beyond those associated with a
reduction in stroke are believed probable then TTE is likely to be cost-effective
in all scenarios. Our findings suggest that further research would be useful,
following up newly diagnosed patients with AF who have undergone TTE, to study
treatments given as a result of TTE diagnoses and subsequent cardiovascular events.
This could identify additional benefits of routine testing, beyond stroke
prevention. Studies assessing the proportion of people with a CHADS2 score of 0 or
1 that have left atrial abnormality would provide better estimates of the cost-
effectiveness of TTE, and allow more accurate estimates of the sensitivity and
specificity of TTE for identifying left atrial abnormality in AF to be obtained.
STUDY REGISTRATION: PROSPERO CRD42011001354. FUNDING: The National Institute for
Health Research Health Technology Assessment programme.
AD - School of Health and Related Research (ScHARR), University of Sheffield,
Sheffield, UK. e.l.simpson@sheffield.ac.uk
AN - 23985296
AU - Simpson, E.
AU - Stevenson, M.
AU - Scope, A.
AU - Poku, E.
AU - Minton, J.
AU - Evans, P.
C2 - PMC4781049
DA - Aug
DO - 10.3310/hta17360
DP - NLM
ET - 2013/08/30
IS - 36
J2 - Health technology assessment (Winchester, England)
KW - Adult
Age Distribution
Aged
Anticoagulants/adverse effects/economics/therapeutic use
Atrial Fibrillation/complications/*diagnostic imaging/*economics/epidemiology
Cardiovascular Diseases/complications/economics/epidemiology/etiology
Comorbidity
Cost-Benefit Analysis
Echocardiography/*economics/methods/standards
Female
Hemorrhage/chemically induced/economics/etiology
Humans
Hypertrophy, Left Ventricular/complications/economics/epidemiology/etiology
Male
Mass Screening/economics/standards
Middle Aged
Prevalence
Quality-Adjusted Life Years
Respiratory Insufficiency/complications/economics/epidemiology/etiology
Risk Assessment
Stroke/complications/economics/epidemiology/*etiology
LA - eng
N1 - 2046-4924
Simpson, El
Stevenson, Md
Scope, A
Poku, E
Minton, J
Evans, P
Journal Article
Review
Systematic Review
Health Technol Assess. 2013 Aug;17(36):1-263, v-vi. doi: 10.3310/hta17360.
PY - 2013
SN - 1366-5278 (Print)
1366-5278
SP - 1-263, v-vi
ST - Echocardiography in newly diagnosed atrial fibrillation patients: a
systematic review and economic evaluation
T2 - Health Technol Assess
TI - Echocardiography in newly diagnosed atrial fibrillation patients: a
systematic review and economic evaluation
VL - 17
ID - 2672
ER -
TY - JOUR
AB - INTRODUCTION: Traumatic brain injury (TBI), subarachnoid hemorrhage (SAH),
stroke and cerebrovascular disease (CVD) are identified as risk factors for
hypopituitarism. Pituitary dysfunction after TBI, SAH, and CVD may present in the
acute phase or later in the course of the event. Chronic hypopituitarism,
particularly growth hormone (GH) deficiency is related to the increased
cardiovascular morbidity and mortality. In patients with serious ventricular
arrhythmias, who need cardiopulmonary resuscitation, brain tissue is exposed to
short-term severe ischemia and hypoxia. However, there are no data in the
literature regarding pituitary dysfunction after ventricular arrhythmias. PATIENTS
AND METHODS: Forty-four patients with ventricular arrhythmias [ventricular
tachycardia (VT), ventricular fibrillation (VF)] (mean age, 55.6 ± 1.8 years; 37
men, 7 women) were included in the study. The patients were evaluated after mean
period of 21.2 ± 0.8 months from VT-VF. Basal hormone levels, including serum free
triiodothyronine (fT3), free thyroxine (fT4), TSH, ACTH, prolactin, FSH, LH, total
testosterone, estradiol, IGF-1, and cortisol levels were measured in all patients.
To assess (GH)-insulin like growth factor-1 (IGF-1) axis, glucagon stimulation test
was performed and 1 µg ACTH stimulation test was used for assessing hypothalamic-
pituitary-adrenal (HPA) axis. RESULTS: The frequencies of GH, gonadotropin and TSH
deficiency were 27.2, 9.0, 2.2%, respectively. Mean IGF-1 levels were lower in GH
deficiency group, but it was not statistically significant. CONCLUSION: The present
preliminary study showed that ventricular arrhythmias may result in
hypopituitarism, particularly in growth hormone deficiency. Unrecognized
hypopituitarism may be responsible for some of the cardiovascular problems at least
in some patients.
AD - Department of Endocrinology, Erciyes University Medical School, 38039,
Kayseri, Turkey.
AN - 25107344
AU - Simsek, Y.
AU - Kaya, M. G.
AU - Tanriverdi, F.
AU - Çalapkorur, B.
AU - Diri, H.
AU - Karaca, Z.
AU - Unluhizarci, K.
AU - Kelestimur, F.
DA - Nov
DO - 10.1007/s40618-014-0142-1
DP - NLM
ET - 2014/08/12
IS - 11
J2 - Journal of endocrinological investigation
KW - Adult
Aged
Aged, 80 and over
Cardiopulmonary Resuscitation/*adverse effects/trends
Female
Humans
Hypopituitarism/blood/diagnosis/epidemiology
Male
Middle Aged
Pilot Projects
Pituitary Diseases/blood/*diagnosis/epidemiology
Pituitary Gland/*physiology
Tachycardia, Ventricular/blood/*diagnosis/epidemiology
Ventricular Fibrillation/blood/*diagnosis/epidemiology
LA - eng
N1 - 1720-8386
Simsek, Y
Kaya, M G
Tanriverdi, F
Çalapkorur, B
Diri, H
Karaca, Z
Unluhizarci, K
Kelestimur, F
Evaluation Study
Journal Article
Italy
J Endocrinol Invest. 2014 Nov;37(11):1057-64. doi: 10.1007/s40618-014-0142-1. Epub
2014 Aug 9.
PY - 2014
SN - 0391-4097
SP - 1057-64
ST - Evaluation of long-term pituitary functions in patients with severe
ventricular arrhythmia: a pilot study
T2 - J Endocrinol Invest
TI - Evaluation of long-term pituitary functions in patients with severe
ventricular arrhythmia: a pilot study
VL - 37
ID - 2567
ER -
TY - JOUR
AB - BACKGROUND: Prolonged QT interval associates with increased risk for sudden
cardiac death after acute ischemic stroke. However, pathophysiology of prolonged QT
interval after stroke is poorly elucidated. In this study, we investigated whether
QT interval dynamics is different in patients with right and left middle cerebral
artery (MCA) territory stroke. METHOD: Electrocardiogram (ECG) intervals were
compared between baseline (retrieved retrospectively from medical records) and
admission (acquired at the acute hospital admission) in 33 patients (65 ± 9.5
years) with right or left MCA territory ischemic stroke. Head computed tomography
(CT), cardiac ultrasound, and cardiac CT scans were undertaken. RESULTS: Stroke was
located in the right MCA territory in 21 (64%) and in the left MCA territory in 12
(36%) patients. Patients with right and left MCA stroke were similar with respect
to time interval between baseline and admission ECG recordings, positive history of
heart disease, and left ventricular dimensions. Increase in heart rate-corrected QT
interval (QTc) from baseline to admission was demonstrated to occur more often in
patients with right (16 of 21; 76%) than in patients with left (3 of 12; 25%; P < .
01) MCA stroke. ΔQTc between baseline and admission was significantly longer in
patients with right (23 ± 23 milliseconds) than in patients with left (-11 ± 19
milliseconds; P < .0001) MCA stroke. Percent ΔQTc between baseline and admission
was longer in patients with right (5.5% ± 5.5%) than in patients with left (-2.6% ±
4.7%; P < .001) MCA stroke. CONCLUSIONS: Right MCA ischemic stroke results in
prolongation of QT interval. Findings indicate cerebral asymmetry in brain-heart
interaction during acute ischemic stroke.
AD - Department of Neurology, Mikkeli Central Hospital, Mikkeli, Finland.
Electronic address: sakari.simula@esshp.fi.
Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland; Unit
of Radiology, University of Eastern Finland, Kuopio, Finland.
Department of Neurology, Kuopio University Hospital, Kuopio, Finland; Unit of
Neurology, University of Eastern Finland, Kuopio, Finland.
Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland; Unit
of Radiology, University of Eastern Finland, Kuopio, Finland; Heart Center, Kuopio
University Hospital, Kuopio, Finland.
AN - 24045085
AU - Simula, S.
AU - Muuronen, A. T.
AU - Taina, M.
AU - Jäkälä, P.
AU - Sipola, P.
AU - Vanninen, R.
AU - Hedman, M.
DA - Apr
DP - NLM
ET - 2013/09/21
IS - 4
KW - Adult
Aged
Aged, 80 and over
Electrocardiography
Female
Functional Laterality/physiology
Head/diagnostic imaging
Heart/diagnostic imaging
Humans
Hypertrophy, Left Ventricular/pathology/physiopathology
Infarction, Middle Cerebral Artery/*physiopathology
Long QT Syndrome/diagnostic imaging/*etiology/physiopathology
Male
Middle Aged
Radiography
Stroke/*physiopathology
Ultrasonography
Ischemic stroke
QT interval electrocardiography
repolarization
LA - eng
N1 - 1532-8511
Simula, Sakari
Muuronen, Antti T
Taina, Mikko
Jäkälä, Pekka
Sipola, Petri
Vanninen, Ritva
Hedman, Marja
Journal Article
United States
J Stroke Cerebrovasc Dis. 2014 Apr;23(4):717-23. doi:
10.1016/j.jstrokecerebrovasdis.2013.06.032. Epub 2013 Sep 14.
PY - 2014
SN - 1052-3057
SP - 717-23
ST - Effect of middle cerebral artery territory ischemic stroke on QT interval
TI - Effect of middle cerebral artery territory ischemic stroke on QT interval
VL - 23
ID - 2429
ER -
TY - JOUR
AB - This chapter about antithrombotic therapy in atrial fibrillation (AF) is part
of the American College of Chest Physicians Evidence-Based Guidelines Clinical
Practice Guidelines (8th Edition). Grade 1 recommendations indicate that most
patients would make the same choice and Grade 2 suggests that individual patient's
values may lead to different choices (for a full understanding of the grading see
Guyatt et al, CHEST 2008; 133[suppl]:123S-131S). Among the key recommendations in
this chapter are the following (all vitamin K antagonist [VKA] recommendations have
a target international normalized ratio [INR] of 2.5; range 2.0-3.0, unless
otherwise noted). In patients with AF, including those with paroxysmal AF, who have
had a prior ischemic stroke, transient ischemic attack (TIA), or systemic embolism,
we recommend long-term anticoagulation with an oral VKA, such as warfarin, because
of the high risk of future ischemic stroke faced by this set of patients (Grade
1A). In patients with AF, including those with paroxysmal AF, who have two or more
of the risk factors for future ischemic stroke listed immediately below, we
recommend long-term anticoagulation with an oral VKA (Grade 1A). Two or more of the
following risk factors apply: age >75 years, history of hypertension, diabetes
mellitus, moderately or severely impaired left ventricular systolic function and/or
heart failure. In patients with AF, including those with paroxysmal AF, with only
one of the risk factors listed immediately above, we recommend long-term
antithrombotic therapy (Grade 1A), either as anticoagulation with an oral VKA, such
as warfarin (Grade 1A), or as aspirin, at a dose of 75-325 mg/d (Grade 1B). In
these patients at intermediate risk of ischemic stroke we suggest a VKA rather than
aspirin (Grade 2A). In patients with AF, including those with paroxysmal AF, age <
or =75 years and with none of the other risk factors listed above, we recommend
long-term aspirin therapy at a dose of 75-325 mg/d (Grade 1B), because of their low
risk of ischemic stroke. For patients with atrial flutter, we recommend that
antithrombotic therapy decisions follow the same risk-based recommendations as for
AF (Grade 1C). For patients with AF and mitral stenosis, we recommend long-term
anticoagulation with an oral VKA (Grade 1B). For patients with AF and prosthetic
heart valves we recommend long-term anticoagulation with an oral VKA at an
intensity appropriate for the specific type of prosthesis (Grade 1B). See CHEST
2008; 133(suppl):593S-629S. For patients with AF of > or =48 h or of unknown
duration for whom pharmacologic or electrical cardioversion is planned, we
recommend anticoagulation with an oral VKA, such as warfarin, for 3 weeks before
elective cardioversion and for at least 4 weeks after sinus rhythm has been
maintained (Grade 1C). For patients with AF of > or = 48 h or of unknown duration
undergoing pharmacological or electrical cardioversion, we also recommend either
immediate anticoagulation with unfractionated IV heparin, or low-molecular-weight
heparin (LMWH), or at least 5 days of warfarin by the time of cardioversion
(achieving an INR of 2.0-3.0) as well as a screening multiplane transesophageal
echocardiography (TEE). If no thrombus is seen, cardioversion is successful, and
sinus rhythm is maintained, we recommend anticoagulation for at least 4 weeks. If a
thrombus is seen on TEE, then cardioversion should be postponed and anticoagulation
should be continued indefinitely. We recommend obtaining a repeat TEE before
attempting later cardioversion (Grade 1B addressing the equivalence of TEE-guided
vs non-TEE-guided cardioversion). For patients with AF of known duration <48 h, we
suggest cardioversion without prolonged anticoagulation (Grade 2C). However, in
patients without contraindications to anticoagulation, we suggest beginning IV
heparin or LMWH at presentation (Grade 2C).
AD - From the Clinical Epidemiology Unit, General Medicine Division, Massachusetts
General Hospital, Boston, MA. Electronic address: dsinger@partners.org.
Stanford University Medical Center, Palo Alto, CA.
Professor Emeritus, University of Arizona.
University of California, San Francisco, San Francisco, CA.
Division of Research, Kaiser Permanente of Northern California, Oakland, CA.
Mt. Sinai Medical Center, New York, NY.
Department of Medicine, University of Birmingham, Birmingham, UK.
Beth Israel Deaconess Medical Center, Boston, MA.
AN - 18574273
AU - Singer, D. E.
AU - Albers, G. W.
AU - Dalen, J. E.
AU - Fang, M. C.
AU - Go, A. S.
AU - Lip, G. Y. H.
AU - Manning, W. J.
DA - Jun
DO - 10.1378/chest.08-0678
DP - NLM
ET - 2008/07/24
IS - 6 Suppl
J2 - Chest
*Evidence-Based Medicine
Heparin, Low-Molecular-Weight/administration & dosage
Humans
Injections, Subcutaneous
Risk Assessment
Risk Factors
Warfarin/administration & dosage
LA - eng
N1 - Singer, Daniel E
Albers, Gregory W
Dalen, James E
Fang, Margaret C
Go, Alan S
Lip, Gregory Y H
Manning, Warren J
AG 15478/AG/NIA NIH HHS/United States
Journal Article
Practice Guideline
United States
Chest. 2008 Jun;133(6 Suppl):546S-592S. doi: 10.1378/chest.08-0678.
PY - 2008
SN - 0012-3692 (Print)
0012-3692
SP - 546s-592s
ST - Antithrombotic therapy in atrial fibrillation: American College of Chest
Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
T2 - Chest
TI - Antithrombotic therapy in atrial fibrillation: American College of Chest
Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
VL - 133
ID - 3051
ER -
TY - JOUR
AB - This chapter about antithrombotic therapy in atrial fibrillation (AF) is part
of the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy: Evidence
Based Guidelines. Grade 1 recommendations are strong and indicate that the benefits
do, or do not, outweigh risks, burden, and costs. Grade 2 suggests that individual
patients' values may lead to different choices (for a full understanding of the
grading see Guyatt et al, CHEST 2004; 126:179S-187S). Among the key recommendations
in this chapter are the following (all vitamin K antagonist [VKA] recommendations
have a target international normalized ratio [INR] of 2.5; range, 2.0 to 3.0): In
patients with persistent or paroxysmal AF (PAF) [intermittent AF] at high risk of
stroke (ie, having any of the following features: prior ischemic stroke, transient
ischemic attack, or systemic embolism, age > 75 years, moderately or severely
impaired left ventricular systolic function and/or congestive heart failure,
history of hypertension, or diabetes mellitus), we recommend anticoagulation with
an oral VKA, such as warfarin (Grade 1A). In patients with persistent AF or PAF,
age 65 to 75 years, in the absence of other risk factors, we recommend
antithrombotic therapy with either an oral VKA or aspirin, 325 mg/d, in this group
of patients who are at intermediate risk of stroke (Grade 1A). In patients with
persistent AF or PAF < 65 years old and with no other risk factors, we recommend
aspirin, 325 mg/d (Grade 1B). For patients with AF and mitral stenosis, we
recommend anticoagulation with an oral VKA (Grade 1C+). For patients with AF and
prosthetic heart valves, we recommend anticoagulation with an oral VKA (Grade 1C+);
the target INR may be increased and aspirin added depending on valve type and
position, and on patient factors. For patients with AF of > or = 48 h or of unknown
duration for whom pharmacologic or electrical cardioversion is planned, we
recommend anticoagulation with an oral VKA for 3 weeks before and for at least 4
weeks after successful cardioversion (Grade 1C+). For patients with AF of > or = 48
h or of unknown duration undergoing pharmacologic or electrical cardioversion, an
alternative strategy is anticoagulation and screening multiplane transesophageal
echocardiography (Grade 1B). If no thrombus is seen and cardioversion is
successful, we recommend anticoagulation for at least 4 weeks (Grade 1B). For
patients with AF of known duration < 48 h, we suggest cardioversion without
anticoagulation (Grade 2C). However, in patients without contraindications to
anticoagulation, we suggest beginning IV heparin or low molecular weight heparin at
presentation (Grade 2C).
AD - Clinical Epidemiology Unit, S50-9, Massachusetts General Hospital, Boston, MA
02114, USA. dsinger@partners.org
AN - 15383480
AU - Singer, D. E.
AU - Albers, G. W.
AU - Dalen, J. E.
AU - Go, A. S.
AU - Manning, W. J.
DA - Sep
DO - 10.1378/chest.126.3_suppl.429S
DP - NLM
ET - 2004/09/24
IS - 3 Suppl
J2 - Chest
KW - Aged
Atrial Fibrillation/blood/complications/*drug therapy
Atrial Flutter/blood/complications/drug therapy
Fibrinolytic Agents/adverse effects/*therapeutic use
Heparin/adverse effects/therapeutic use
Heparin, Low-Molecular-Weight/adverse effects/therapeutic use
Humans
Risk Assessment
Risk Factors
Stroke/blood/*prevention & control
LA - eng
N1 - Singer, Daniel E
Albers, Gregory W
Dalen, James E
Go, Alan S
Manning, Warren J
Guideline
Journal Article
Practice Guideline
Review
United States
Chest. 2004 Sep;126(3 Suppl):429S-456S. doi: 10.1378/chest.126.3_suppl.429S.
PY - 2004
SN - 0012-3692 (Print)
0012-3692
SP - 429s-456s
ST - Antithrombotic therapy in atrial fibrillation: the Seventh ACCP Conference on
Antithrombotic and Thrombolytic Therapy
T2 - Chest
TI - Antithrombotic therapy in atrial fibrillation: the Seventh ACCP Conference on
Antithrombotic and Thrombolytic Therapy
VL - 126
ID - 2635
ER -
TY - JOUR
AB - Atrial fibrillation is a common condition affecting elderly individuals; as
many as 10% of people older than age 80 years have AF. AF is also a potent risk
factor for ischemic stroke, raising the risk of stroke fivefold. A set of
consistent randomized controlled trials has demonstrated that long-term
anticoagulation can largely reverse the risk of stroke attributable to AF. In these
trials, anticoagulation generally proved quite safe, raising the risk of
intracranial hemorrhage by less than 0.5% per year. The anticoagulation target for
AF is INR 2 to 3 with INR 2.5 as the specific goal. The trials were much less
consistent about the efficacy of aspirin, although it seems that aspirin has a
small stroke-preventive effect. The recommended dose of aspirin is 325 mg per day.
Because it raises the risk of hemorrhage and adds the burden of frequent monitoring
of INR values, anticoagulation is recommended for those patients with AF at higher
risk of stroke. Such higher risk is conferred by the following risk factors: (1) a
history of a prior stroke, TIA, or other systemic embolic event; (2) a history of
hypertension; (3) diabetes mellitus; (4) left ventricular dysfunction; (5) mitral
stenosis; and (6) older age. The exact age threshold conferring sufficiently
increased risk is uncertain, with some research indicating the threshold should be
age 65 years, and other research indicating the threshold should be age 75 years.
For lower-risk patients, aspirin is recommended. Future research should focus on
the oldest patients with AF. These individuals face the highest risk of ischemic
stroke without anticoagulation and the highest risk of major hemorrhage with
anticoagulation. Only small numbers of such elderly patients were included in the
randomized trials. Future research should also focus on improved risk
stratification, allowing better targeting of anticoagulation. Discoveries of new
antithrombotic agents and new drugs and devices for preservation of sinus rhythm
could radically improve stroke-preventive strategies for AF.
AD - Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
dsinger@partners.org
AN - 11270126
AU - Singer, D. E.
AU - Go, A. S.
DA - Feb
DO - 10.1016/s0749-0690(05)70110-5
DP - NLM
ET - 2001/03/29
IS - 1
J2 - Clinics in geriatric medicine
KW - Age Factors
Aged
Aged, 80 and over
Atrial Fibrillation/complications/*drug therapy/epidemiology
Female
Fibrinolytic Agents/*administration & dosage/adverse effects
Humans
Incidence
Male
Prognosis
Risk Factors
Stroke/*drug therapy/epidemiology/etiology
Survival Rate
LA - eng
N1 - Singer, D E
Go, A S
AG 15478/AG/NIA NIH HHS/United States
Journal Article
Review
United States
Clin Geriatr Med. 2001 Feb;17(1):131-47. doi: 10.1016/s0749-0690(05)70110-5.
PY - 2001
SN - 0749-0690 (Print)
0749-0690
SP - 131-47
ST - Antithrombotic therapy in atrial fibrillation
T2 - Clin Geriatr Med
TI - Antithrombotic therapy in atrial fibrillation
VL - 17
ID - 2501
ER -
TY - JOUR
AB - Third-generation implantable cardioverter defibrillators (ICDs) are designed
to provide tiered therapy for ventricular tachycardia and ventricular fibrillation.
At present, however, therapy prescription does not take into account the
hemodynamic consequences of ventricular dysrhythmias. Design of "intelligent"
devices depends on their ability to assess hemodynamic consequences of
tachyarrhythmias and end-organ perfusion. Quantitative electroencephalography
(QEEG) and transcranial Doppler flow provide sensitive and specific measures of
cerebral perfusion during ICD testing and programming. In response to prolonged
hypotension (> 15 seconds), transient loss of alpha power (i.e., increase in delta
power) in the EEG spectrum, accompanied by impaired cerebrovasomotor reactivity
(CVR), was observed in 25 of 91 hypotensive episodes in 15 patients, ages 36 to 72
years, predicting intolerance to the programmed ICD therapy. Conversely, intact CVR
prevented ischemia, slowing in the EEG, and predicted tolerance to the therapy
prescription. These changes were exaggerated in the erect posture during tilt-table
ICD testing. During ventricular tachycardia, signs of cerebral hypoxia detected by
QEEG and Doppler techniques were accompanied by a fall in transcranial
oxyhemoglobin saturation measured by near-infrared spectroscopy. We conclude that
transcranial Doppler and QEEG are sensitive indicators of cerebral perfusion. These
techniques could be used as indexes of perfusion against which hemodynamic sensors
for future ICDs could be evaluated.
AD - Division of Cardiology, University of Louisville, KY 40292.
AN - 7909187
AU - Singer, I.
AU - Edmonds, H., Jr.
DA - Apr
DO - 10.1016/0002-8703(94)90086-8
DP - NLM
ET - 1994/04/01
IS - 4 Pt 2
KW - Adult
Aged
Cerebrovascular Circulation/*physiology
Electroencephalography/methods
Female
Humans
Male
Middle Aged
Monitoring, Physiologic/methods
Oxyhemoglobins/analysis
Posture/physiology
Tachycardia, Ventricular/physiopathology/*therapy
LA - eng
N1 - Singer, I
Edmonds, H Jr
Journal Article
United States
Am Heart J. 1994 Apr;127(4 Pt 2):1052-7. doi: 10.1016/0002-8703(94)90086-8.
PY - 1994
SN - 0002-8703 (Print)
0002-8703
SP - 1052-7
ST - Changes in cerebral perfusion during third-generation implantable
cardioverter defibrillator testing
T2 - Am Heart J
TI - Changes in cerebral perfusion during third-generation implantable
cardioverter defibrillator testing
VL - 127
ID - 2781
ER -
TY - JOUR
AB - Determination of defibrillation thresholds (DFTs) and implantable
cardioverter defibrillator (ICD) testing requires repeated inductions of
ventricular fibrillation (VF) and defibrillation attempts using known energy
outputs. Little is known about the individual and cumulative effects of repetitive
brief episodes of VF and hypoperfusion on cerebral function. The potential clinical
utility of quantitative electroencephalographic (QEEG) monitoring during
intraoperative ICD testing, by using processed 19-channel EEG (0.5-35 Hz
bandwidth), was examined in ten anesthetized patients, five males and five females
(mean age 62 +/- 10 years), who underwent ICD implantation and testing. Ischemic
QEEG patterns were defined as those with a 3 standard deviation increase (P less
than 0.01) in absolute delta (1.5-3.5 Hz) power persisting for greater than or
equal to 2.5 minutes. The majority (80%) of the VF episodes (70) were accompanied
by QEEG "slowing" (doubling of the pre-VF low frequency delta waves amplitude). All
the patients (5/5) experiencing greater than 6 VF episodes showed a statistically
significant increase in the low frequency amplitude. In contrast, this EEG
abnormality was apparent in only one of five patients experiencing less than 6 VF
episodes. These results suggest a cumulative QEEG depression associated with ICD
testing. QEEG may provide an objective means for establishing an individualized
upper safe limit of DFT testing and the total number of induced VF episodes.
AD - Cardiovascular Division, University of Louisville, Kentucky 40292.
AN - 1721196
AU - Singer, I.
AU - van der Laken, J.
AU - Edmonds, H. L., Jr.
AU - Slater, A. D.
AU - Austin, E.
AU - Shields, C. B.
AU - Kupersmith, J.
DA - Nov
DO - 10.1111/j.1540-8159.1991.tb02787.x
DP - NLM
ET - 1991/11/11
IS - 11 Pt 2
KW - Electric Countershock/*instrumentation
Electroencephalography/*methods
Feasibility Studies
Female
Humans
Male
Middle Aged
Monitoring, Intraoperative
*Prostheses and Implants
*Safety
Ventricular Fibrillation/*etiology/therapy
LA - eng
N1 - Singer, I
van der Laken, J
Edmonds, H L Jr
Slater, A D
Austin, E
Shields, C B
Kupersmith, J
Journal Article
United States
Pacing Clin Electrophysiol. 1991 Nov;14(11 Pt 2):1899-904. doi: 10.1111/j.1540-
8159.1991.tb02787.x.
PY - 1991
SN - 0147-8389 (Print)
0147-8389
SP - 1899-904
ST - Is defibrillation testing safe?
TI - Is defibrillation testing safe?
VL - 14
ID - 2721
ER -
TY - JOUR
AB - BACKGROUND: Atrial fibrillation (AF) that occurs as a frequent complication
of myocardial infarction (MI) is associated with a poor clinical outcome. It
nonetheless remains uncertain whether AF that occurs transiently during MI is
associated with a subsequent increased risk of the development of AF and ischemic
stroke. METHODS: We retrospectively studied the impact of transient AF on the long-
term risk of the occurrence of AF, ischemic stroke, and mortality in 431
consecutive patients (mean [+/- SEM] age, 64 +/- 1 years; 75% men). All patients
had experienced an acute inferior ST-segment-elevation MI and had preserved left
ventricular ejection fraction (LVEF) [> 45%]. RESULTS: All patients were in sinus
rhythm on hospital admission, and transient AF was observed in 59 patients (13.7%)
during their hospitalization for MI. On hospital discharge, all patients were in
sinus rhythm and had been prescribed antiplatelet agents alone as antithrombotic
therapy. Patients in whom transient AF developed during MI were older (mean age, 70
+/- 1.4 vs 64 +/- 0.7 years, respectively; p < 0.01) and more likely to be women
(37% vs 23%, respectively; p < 0.02) compared with those without AF. At 1-year
follow-up, the incidence of AF (22.0% vs 1.3%, respectively; p < 0.01) and ischemic
stroke (10.2% vs 1.8%, respectively; p < 0.01) was higher in patients with
transient AF than in those without transient AF. The total mortality rate was
nonetheless similar (5.6% vs 6.8%, respectively; p = 0.73); Cox regression analysis
demonstrated that age > 65 years and transient AF during MI were independent
predictors of the subsequent occurrence of AF and the development of ischemic
stroke. CONCLUSION: Transient AF complicating acute inferior MI is associated with
an increased future risk of AF occurrence and ischemic stroke in patients with
preserved LVEF, despite the use of antiplatelet therapy.
AD - Cardiology Division, Department of Medicine, The University of Hong Kong,
Queen Mary Hospital, Hong Kong, People's Republic of China.
AN - 17400657
AU - Siu, C. W.
AU - Jim, M. H.
AU - Ho, H. H.
AU - Miu, R.
AU - Lee, S. W.
AU - Lau, C. P.
AU - Tse, H. F.
DA - Jul
DO - 10.1378/chest.06-2733
DP - NLM
ET - 2007/04/03
IS - 1
J2 - Chest
KW - Aged
Atrial Fibrillation/*complications/*etiology/physiopathology
Female
Humans
Male
Middle Aged
Myocardial Infarction/*complications/drug therapy/physiopathology
Regression Analysis
Risk Factors
Stroke/*etiology/physiopathology/prevention & control
Treatment Outcome
LA - eng
N1 - Siu, Chung-Wah
Jim, Man-Hong
Ho, Hee-Hwa
Miu, Raymond
Lee, Stephen W L
Lau, Chu-Pak
Tse, Hung-Fat
Journal Article
United States
Chest. 2007 Jul;132(1):44-9. doi: 10.1378/chest.06-2733. Epub 2007 Mar 30.
PY - 2007
SN - 0012-3692 (Print)
0012-3692
SP - 44-9
ST - Transient atrial fibrillation complicating acute inferior myocardial
infarction: implications for future risk of ischemic stroke
T2 - Chest
TI - Transient atrial fibrillation complicating acute inferior myocardial
infarction: implications for future risk of ischemic stroke
VL - 132
ID - 2485
ER -
TY - JOUR
AB - Left ventricular (LV) systolic dysfunction and chronic systolic heart failure
(HF) predispose to intraventricular thrombus formation and embolization resulting
in stroke. Current guideline recommends the use of oral anticoagulants in patients
with atrial fibrillation and history of previous thromboembolism. However,
anticoagulant treatment in patients with LV systolic dysfunction with sinus rhythm
and without history of previous thromboembolism is still on debate. Recent
epidemiologic date has reported increased stroke rate in patients with systolic HF
shortly after diagnosis. This review focuses on the possible causes of increased
stroke rate shortly after the diagnosis of HF and subsequently suggests a rationale
for the use of oral anticoagulant in these patient groups.
AD - Department of Cardiology, Faculty of Medicine, Trakya University, Edirne,
Turkey nasirsivri@hotmail.com.
Division of Cardiology, Middle East Hospital, Mersin, Turkey.
Department of Cardiology, Faculty of Medicine, Bozok University, Yozgat, Turkey.
Department of Cardiology, Faculty of Medicine, Trakya University, Edirne, Turkey.
Department of Cardiology and Angiology, University Hospital of Muenster, Germany.
AN - 23615290
AU - Sivri, N.
AU - Yetkin, E.
AU - Tekin, G. O.
AU - Yalta, K.
AU - Waltenberger, J.
DA - Oct
DO - 10.1177/1076029613486017
DP - NLM
ET - 2013/04/26
IS - 7
J2 - Clinical and applied thrombosis/hemostasis : official journal of the
International Academy of Clinical and Applied Thrombosis/Hemostasis
KW - Adult
Heart Failure, Systolic/complications/*drug therapy/physiopathology
Humans
Stroke/etiology/physiopathology/prevention & control
Tachycardia, Sinus/complications/*drug therapy/physiopathology
Thromboembolism/etiology/physiopathology/prevention & control
Ventricular Dysfunction, Left/complications/*drug therapy/physiopathology
anticogulant
stroke
thrombosis
LA - eng
N1 - 1938-2723
Sivri, Nasir
Yetkin, Ertan
Tekin, Gulacan Ozgun
Yalta, Kenan
Waltenberger, Johannes
Journal Article
Review
United States
Clin Appl Thromb Hemost. 2014 Oct;20(7):729-34. doi: 10.1177/1076029613486017. Epub
2013 Apr 23.
PY - 2014
SN - 1076-0296
SP - 729-34
ST - Anticoagulation in patients with left ventricular systolic dysfunction and
sinus rhythm: when?
T2 - Clin Appl Thromb Hemost
TI - Anticoagulation in patients with left ventricular systolic dysfunction and
sinus rhythm: when?
VL - 20
ID - 2472
ER -
TY - JOUR
AB - Asymptomatic paroxysmal atrial fibrillation (PAF) is often assumed to be the
cause of cryptogenic ischemic strokes (IS) and transient ischemic attacks (TIA). We
examined the usefulness of measures obtained by 2D speckle tracking
echocardiography and novel left atrial measurements, in the diagnosis of PAF in
patients with IS and TIA. We retrospectively included 205 patients who after acute
IS or TIA underwent an echocardiogram in sinus rhythm. Patients were designated as
PAF-patients if they had one or more reported incidents of AF before or after their
echocardiographic examination. None of the conventional echocardiographic
parameters were significantly associated with PAF. Of the speckle tracking
measurements, only early diastolic strain rate (0.7±0.2 s(-1) vs. 0.8±0.3 s(-1), p
= 0.048) and global longitudinal displacement (GLD) (3.15 ± 1.40 mm vs. 3.87 ±
1.56 mm, p = 0.007) proved significantly different. Of the left atrial parameters
both minimal and maximal left atrium volume divided by left ventricular length (min
LAV/LVL and max LAV/LVL, respectively) were significantly impaired (min LAV/LVL:
3.7 ± 2.1 cm(2) vs. 2.8 ± 1.11 cm(2), p = 0.012; max LAV/LVL: 6.6 ± 3.1 cm(2) vs.
5.6 ± 1.7 cm(2), p = 0.012). GLD, min max LAV/LVL proved significant after
adjustment for age, gender, CHA(2)DS(2)-VASc and NIHSS. By combining information
regarding age, GLD, min and max LAV/LVL the diagnostic accuracy of PAF improved,
resulting in a significantly increased area under the curve (p = 0.037). In
patients with IS and TIA GLD, min and max LAV/LVL were independently associated
with the presence of PAF.
AD - Department of Cardiology, Herlev & Gentofte Hospital, University of
Copenhagen, Post 835, Kildegårdsvej 28, 2900, Copenhagen, Denmark.
kristofferskaarup@hotmail.com.
Department of Neurology, Bispebjerg Hospital, University of Copenhagen, Copenhagen,
Denmark. kristofferskaarup@hotmail.com.
Department of Neurology, Bispebjerg Hospital, University of Copenhagen, Copenhagen,
Denmark.
Institute of Clinical Medicine, Faculty of Health Sciences, University of
Copenhagen, Copenhagen, Denmark.
Department of Cardiology, Bispebjerg Hospital, University of Copenhagen,
Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen,
Post 835, Kildegårdsvej 28, 2900, Copenhagen, Denmark.
AN - 28664480
AU - Skaarup, K. G.
AU - Christensen, H.
AU - Høst, N.
AU - Mahmoud, M. M.
AU - Ovesen, C.
AU - Olsen, F. J.
AU - Jensen, J. S.
DA - Dec
DO - 10.1007/s10554-017-1204-1
DP - NLM
ET - 2017/07/01
IS - 12
KW - Adult
Aged
Aged, 80 and over
Area Under Curve
Atrial Fibrillation/complications/*diagnostic imaging/physiopathology
Female
Humans
Image Interpretation, Computer-Assisted
Ischemic Attack, Transient/diagnosis/*etiology/physiopathology
Male
Middle Aged
ROC Curve
Registries
Risk Factors
2D-Speckle tracking
Atrial fibrillation
Echocardiography
Ischemic stroke
Transient ischemic attack
LA - eng
N1 - 1875-8312
Skaarup, Kristoffer Grundtvig
Orcid: 0000-0002-2690-7511
Christensen, Hanne
Høst, Nis
Mahmoud, Masti Mahdy
Ovesen, Christian
Jensen, Jan Skov
Evaluation Study
Journal Article
United States
Int J Cardiovasc Imaging. 2017 Dec;33(12):1921-1929. doi: 10.1007/s10554-017-1204-
1. Epub 2017 Jun 29.
PY - 2017
SN - 1569-5794
SP - 1921-1929
ST - Usefulness of left ventricular speckle tracking echocardiography and novel
measures of left atrial structure and function in diagnosing paroxysmal atrial
fibrillation in ischemic stroke and transient ischemic attack patients
TI - Usefulness of left ventricular speckle tracking echocardiography and novel
measures of left atrial structure and function in diagnosing paroxysmal atrial
fibrillation in ischemic stroke and transient ischemic attack patients
VL - 33
ID - 2351
ER -
TY - JOUR
AN - 13247760
AU - Skalnik, L.
DA - May
DP - NLM
ET - 1955/05/01
IS - 5
J2 - Vnitrni lekarstvi
KW - *Heart Block
*Heart Septum
Humans
*Stroke
*Ventricular Septal Rupture
*Ventricular Septum
*CARDIAC SEPTUM/perforation
*MYOCARDIAL INFARCT/complications
LA - cze
N1 - Skalnik, l
Journal Article
Czech Republic
Vnitr Lek. 1955 May;1(5):331-3.
OP - Infarkt srde6cnäho svalu komplikovaný syndromem Adamsovým-Stokesovým a
prodĕravĕnäm p6repá6zky komorové za 6ziva rozpoznaným.
PY - 1955
SN - 0042-773X (Print)
0042-773x
SP - 331-3
ST - [Myocardial infarct complicated by Adams-Strokes syndrome and perforation of
ventricular septum diagnosed during life]
T2 - Vnitr Lek
TI - [Myocardial infarct complicated by Adams-Strokes syndrome and perforation of
ventricular septum diagnosed during life]
VL - 1
ID - 2769
ER -
TY - JOUR
AB - Heart failure (HF) and atrial fibrillation (AF) share common risk factors and
frequently coexist. Both are highly prevalent in our aging population, and
mortality associated with the combination is significantly higher than for each
alone. An intricate link exists between AF and HF, including interrelated
mechanisms and pathophysiology. Asymptomatic left ventricular systolic or diastolic
dysfunction can exacerbate or be exacerbated by AF, resulting in HF with reduced
ejection fraction or preserved ejection fraction. A number of treatment strategies
have improved symptoms, exercise tolerance, and quality of life for patients with
HF, but few have resulted in alteration in prognosis. Sinus rhythm, achieved
pharmacologically, has not altered important outcomes, including cardiovascular or
total mortality in patients with HF. In recent studies, catheter ablation to
achieve sinus rhythm seems to have a significant impact on symptoms, heart
function, and possibly mortality. Until future studies can confirm or clarify the
impact of catheter ablation on outcomes, the field remains cautious but optimistic
that better treatment strategies for patients with HF with reduced ejection
fraction or preserved ejection fraction are within reach.
AD - London Heart Rhythm Program, Western University, London, Ontario, Canada.
Electronic address: askanes@uwo.ca.
London Heart Rhythm Program, Western University, London, Ontario, Canada.
AN - 30404749
AU - Skanes, A. C.
AU - Tang, A. S. L.
DA - Nov
DO - 10.1016/j.cjca.2018.07.483
DP - NLM
ET - 2018/11/09
IS - 11
Atrial Remodeling/physiology
Cardiac Resynchronization Therapy
Catheter Ablation
Heart Failure/physiopathology/*therapy
Humans
Mineralocorticoid Receptor Antagonists/therapeutic use
Stroke/physiopathology/prevention & control
LA - eng
N1 - 1916-7075
Skanes, Allan C
Tang, Anthony S L
CIHR/Canada
Journal Article
Review
England
Can J Cardiol. 2018 Nov;34(11):1437-1448. doi: 10.1016/j.cjca.2018.07.483. Epub
2018 Aug 20.
PY - 2018
SN - 0828-282x
SP - 1437-1448
ST - Atrial Fibrillation and Heart Failure: Untangling a Modern Gordian Knot
T2 - Can J Cardiol
TI - Atrial Fibrillation and Heart Failure: Untangling a Modern Gordian Knot
VL - 34
ID - 2342
ER -
TY - JOUR
AB - Psychosocial stressors are risk factors for sudden cardiac death. A
theoretical model of the brain mechanism that links defined environmental events
(stressors) to cardiac vulnerability (initiation of ventricular fibrillation) has
been developed. In the model, a stressor event evokes a set of electrochemical
responses in the frontal cortex. Depending on the state of acquisition of these
electrochemical responses to the stressor, activity will or will not be initiated
in the frontocortical-brainstem pathway. Activity in this pathway, either alone or
in combination with myocardial ischemia, triggers a state of increased
vulnerability of the heart to the initiation of ventricular fibrillation. Three
independent interventions have been shown to prevent the initiation of ventricular
fibrillation after acute coronary artery occlusion in the psychologically stressed
pig: 1) learned behavioral adaptation to the stressor, 2) cryogenic blockade of the
frontocortical-brainstem pathway, and 3) intracerebral (but not intravenous)
injection of a beta-receptor blocking agent (levo-propranolol).
AN - 3923079
AU - Skinner, J. E.
DA - Jun
DO - 10.1016/s0735-1097(85)80534-9
DP - NLM
ET - 1985/06/01
IS - 6 Suppl
KW - Animals
Anti-Arrhythmia Agents/pharmacology
Brain Chemistry/drug effects
Electrochemistry
Frontal Lobe/physiopathology
Haplorhini
Humans
Models, Biological
Norepinephrine/physiology
Pressoreceptors/physiology
Propranolol/pharmacology
Stress, Psychological/physiopathology
Swine
Ventricular Fibrillation/*physiopathology
LA - eng
N1 - Skinner, J E
Journal Article
Review
United States
J Am Coll Cardiol. 1985 Jun;5(6 Suppl):88B-94B. doi: 10.1016/s0735-1097(85)80534-9.
PY - 1985
SN - 0735-1097 (Print)
0735-1097
SP - 88b-94b
ST - Regulation of cardiac vulnerability by the cerebral defense system
TI - Regulation of cardiac vulnerability by the cerebral defense system
VL - 5
ID - 2832
ER -
TY - JOUR
AB - The hypothesis tested was that functional blockade of a pathway known to
travel from the frontal cortex through the posterior hypothalamus to the brain stem
might prevent the occurrence of ventricular fibrillation (VF) in the ischemic heart
of conscious stressed pigs. The hypothesis was based on previous findings that 1)
psychological stress is a necessary factor for the initiation of VF in the ischemic
heart of conscious pigs, 2) the frontal cortex and its related thalamic gating
mechanism, uniquely show neuroelectric responses to stressful stimuli, and 3)
direct electric stimulation of either the frontal cortex, posterior hypothalamus,
or fields of Forel will produce ventricular arrhythmias and myocardial necrosis. In
the present study it was found that cryogenic blockade of the forebrain, posterior
hypothalamus, or fields of Forel prevents or delays VF after left anterior
descending coronary artery occlusion in conscious stressed pigs (P less than 0.01).
Blockade of control structures adjacent to these loci in another group of pigs had
no effect on VF latency. Neither heart rate nor electroencephalographic changes
could explain the differences between the groups. The results show that blockade of
the frontocortical-brain stem pathway prevents the lethal consequences of
myocardial ischemia in stressed animals.
AN - 7193421
AU - Skinner, J. E.
AU - Reed, J. C.
DA - Feb
DO - 10.1152/ajpheart.1981.240.2.H156
DP - NLM
ET - 1981/02/01
IS - 2
J2 - The American journal of physiology
KW - Animals
Brain Stem/*physiopathology
Cerebral Cortex/physiopathology
*Cold Temperature
Coronary Disease/*complications/physiopathology
Humans
Hypothalamus, Posterior/physiopathology
Stress, Psychological/complications/*physiopathology
Swine/physiology
LA - eng
N1 - Skinner, J E
Reed, J C
Journal Article
United States
Am J Physiol. 1981 Feb;240(2):H156-63. doi: 10.1152/ajpheart.1981.240.2.H156.
PY - 1981
SN - 0002-9513 (Print)
0002-9513
SP - H156-63
ST - Blockade of frontocortical-brain stem pathway prevents ventricular
fibrillation of ischemic heart
T2 - Am J Physiol
TI - Blockade of frontocortical-brain stem pathway prevents ventricular
fibrillation of ischemic heart
VL - 240
ID - 3010
ER -
TY - JOUR
AB - OBJECTIVES: The purpose of this study was to examine the association between
prolongation of QT interval corrected for heart rate (QTc) with incident stroke.
BACKGROUND: Unlike cardiovascular morbidity and mortality, little is known about
the relationship between QTc and risk of stroke. METHODS: A total of 27,411
participants age 45 years and older without previous stroke from the REGARDS
(REasons for Geographic and Racial Differences in Stroke) study were included in
this analysis. QTc was calculated using Framingham formula (QTc(Fram)). Stroke
cases were identified and adjudicated during up to 8.2 years of follow-up (median,
5.1 years). RESULTS: The risk of incident stroke in study participants with
prolonged QTc(Fram) was almost 3 times the risk in those with normal QTc(Fram)
(hazard ratio [HR] [95% confidence interval (CI)]: 2.88 [2.12 to 3.92], p <
0.0001). After adjustment for demographics (age, race, and sex), traditional stroke
risk factors (antihypertensive medication use, systolic blood pressure, current
smoking, diabetes, left ventricular hypertrophy, atrial fibrillation, and previous
cardiovascular disease), warfarin use, aspirin use, QRS duration and use of QTc-
prolonging drugs, the risk of stroke remained significantly high (HR [95% CI]: 1.67
[1.16 to 2.41], p = 0.0061) and was consistent across several subgroups of REGARDS
study participants. Similar results were obtained when the risk of stroke was
estimated per 1-SD increase in QTc(Fram), (HR [95% CI]: 1.12 [1.03 to 1.21], p =
0.0053 in multivariable-adjusted model) and when other QTc correction formulas
including those of Hodge, Bazett, and Fridericia were used. CONCLUSIONS: QTc
prolongation is associated with a significantly increased risk of incident stroke
independent of traditional stroke risk factors. Examining the risk of stroke
associated with QTc-prolonging drugs may be warranted.
AD - Epidemiological Cardiology Research Center, Department of Epidemiology and
Prevention, Division of Public Health Sciences, Wake Forest School of Medicine,
Winston-Salem, North Carolina, USA. esoliman@wfubmc.edu
AN - 22497826
AU - Soliman, E. Z.
AU - Howard, G.
AU - Cushman, M.
AU - Kissela, B.
AU - Le, A.
AU - Judd, S.
AU - McClure, L. A.
AU - Howard, V. J.
C2 - PMC3345207
C6 - NIHMS367521
DA - Apr 17
DO - 10.1016/j.jacc.2012.01.025
DP - NLM
ET - 2012/04/14
IS - 16
KW - Aged
Female
Follow-Up Studies
Heart Rate
Humans
Incidence
Long QT Syndrome/*complications/epidemiology/physiopathology
Male
Middle Aged
Prognosis
Risk Factors
Stroke/ethnology/*etiology
LA - eng
N1 - 1558-3597
Soliman, Elsayed Z
Howard, George
Cushman, Mary
Kissela, Brett
Kleindorfer, Dawn
Le, Anh
Judd, Suzanne
McClure, Leslie A
Howard, Virginia J
Comparative Study
Journal Article
Multicenter Study
J Am Coll Cardiol. 2012 Apr 17;59(16):1460-7. doi: 10.1016/j.jacc.2012.01.025.
PY - 2012
SN - 0735-1097 (Print)
0735-1097
SP - 1460-7
ST - Prolongation of QTc and risk of stroke: The REGARDS (REasons for Geographic
and Racial Differences in Stroke) study
TI - Prolongation of QTc and risk of stroke: The REGARDS (REasons for Geographic
and Racial Differences in Stroke) study
VL - 59
ID - 2347
ER -
TY - JOUR
AB - OBJECTIVES: In this propensity-matched analysis of post-left atrial appendage
closure antithrombotic therapy, the safety and effectiveness of oral
anticoagulation (OAC) and antiplatelet therapy (APT) were compared. BACKGROUND:
Left atrial appendage closure with the WATCHMAN device is an alternative to OAC in
patients with nonvalvular atrial fibrillation, who are at high bleeding risk.
Initial trials included 45 days of post-implantation OAC, but registry data suggest
that APT may suffice. METHODS: Patients from the PROTECT-AF (Watchman Left Atrial
Appendage System for Embolic Protection in Patients With Atrial Fibrillation),
PREVAIL (Watchman LAA Closure Device in Patients With Atrial Fibrillation Versus
Long Term Warfarin Therapy), CAP (Continued Access to PROTECT-AF), CAP2 (Continued
Access to PREVAIL), ASAP (ASA Plavix Feasibility Study With Watchman Left Atrial
Appendage Closure Technology), and EWOLUTION (Registry on WATCHMAN Outcomes in
Real-Life Utilization) trials receiving either OAC or APT post-implantation were
matched and compared for nonprocedural bleeding and stroke or systemic
thromboembolism over 6 months following implantation. Each patient on APT was
matched with 2 patients on OAC, with propensity scores derived from age, sex,
congestive heart failure, hypertension, diabetes, prior transient ischemic attack
or stroke, peripheral vascular disease, left ventricular ejection fraction, renal
impairment, and different atrial fibrillation subtypes. RESULTS: The cohort on OAC
(n = 1,018; 95% receiving warfarin and 5% receiving nonwarfarin OAC) was prescribed
45-day OAC post-implantation (92% also received single APT), followed by 6-month
single or dual APT. The cohort on APT (n = 509; 91% receiving dual APT and 9%
receiving single APT) received APT for variable durations. Six-month freedom from
nonprocedural major bleeding was similar (OAC, 95.7%; APT, 95.5%; p = 0.775)
despite more early bleeds with OAC. Freedom from thromboembolism beyond 7 days was
similar between groups (OAC, 98.8%; APT, 99.4%; p = 0.089). However, device-related
thrombosis was more frequent with APT (OAC, 1.4%; APT, 3.1%; p = 0.018).
CONCLUSIONS: After left atrial appendage closure with the WATCHMAN, although
device-related thrombosis was more common with APT, both APT and OAC strategies
resulted in similar safety and efficacy endpoints.
AD - Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. Electronic
address: lars.00.soendergaard@rh.regionh.dk.
Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; Medicine and
Geriatric Department, Tuen Mun Hospital, Hong Kong, China.
Icahn School of Medicine at Mount Sinai, New York, New York.
St. Antonius Hospital, Nieuwegein, the Netherlands.
Cardiologicum Hamburg, Hamburg, Germany.
Providence St. John's Health Center, Santa Monica, California.
Cedars-Sinai Medical Center, Los Angeles, California.
CardioVascular Center Frankfurt, Frankfurt am Main, Germany.
Boston Scientific, Minneapolis, Minnesota.
AN - 31171282
AU - Søndergaard, L.
AU - Wong, Y. H.
AU - Reddy, V. Y.
AU - Boersma, L. V. A.
AU - Bergmann, M. W.
AU - Doshi, S.
AU - Kar, S.
AU - Sievert, H.
AU - Wehrenberg, S.
AU - Stein, K.
AU - Holmes, D. R., Jr.
DA - Jun 10
DO - 10.1016/j.jcin.2019.04.004
DP - NLM
ET - 2019/06/07
IS - 11
J2 - JACC. Cardiovascular interventions
Adult
Aged
Aged, 80 and over
*Atrial Appendage/diagnostic imaging/physiopathology
Atrial Fibrillation/complications/diagnosis/physiopathology/*therapy
Cardiac Catheterization/adverse effects/*instrumentation
Female
Humans
Male
Middle Aged
Platelet Aggregation Inhibitors/*administration & dosage/adverse effects
Prosthesis Design
Registries
Risk Assessment
Risk Factors
Thromboembolism/diagnosis/etiology/*prevention & control
Time Factors
Treatment Outcome
*antiplatelet therapy
*antithrombotic therapy
*direct oral anticoagulation
*left atrial appendage closure
*oral anticoagulation
*stroke
LA - eng
N1 - 1876-7605
Søndergaard, Lars
Wong, Yam-Hong
Reddy, Vivek Y
Boersma, Lucas V A
Bergmann, Martin W
Doshi, Shephal
Kar, Saibal
Sievert, Horst
Wehrenberg, Scott
Stein, Kenneth
Holmes, David R Jr
Comparative Study
Journal Article
United States
JACC Cardiovasc Interv. 2019 Jun 10;12(11):1055-1063. doi:
10.1016/j.jcin.2019.04.004.
PY - 2019
SN - 1936-8798
SP - 1055-1063
ST - Propensity-Matched Comparison of Oral Anticoagulation Versus Antiplatelet
Therapy After Left Atrial Appendage Closure With WATCHMAN
T2 - JACC Cardiovasc Interv
TI - Propensity-Matched Comparison of Oral Anticoagulation Versus Antiplatelet
Therapy After Left Atrial Appendage Closure With WATCHMAN
VL - 12
ID - 2296
ER -
TY - JOUR
AB - BACKGROUND: There are limited data about modes of death and major adverse
cardiovascular events (MACEs) in patients with hypertrophic cardiomyopathy (HCM) in
South East Asian population. The aim of the study was to examine modes of death and
clinical outcomes in Thai patients with HCM. METHODS: Between January 1, 2009 and
December 31, 2013, 166 consecutive patients with HCM diagnosed in our institution
were evaluated. Five patients were excluded because of non-Thai ethnic groups (n =
3) and diagnosis of myocardial infarction at initial presentation documented by
coronary angiography (n = 2). The final study population consisted of 161 patients
with HCM. HCM-related deaths included: (1) sudden cardiac death (SCD) - death due
to sudden cardiac arrest or unexpected sudden death; (2) heart failure - death due
to refractory heart failure; or (3) stroke - death due to embolic stroke associated
with atrial fibrillation. MACEs included: (1) SCD, sudden unexpected aborted
cardiac arrest, fatal, or nonfatal ventricular arrhythmia (ventricular fibrillation
or sustained ventricular tachycardia); (2) heart failure (fatal or non-fatal), or
heart transplantation; or (3) stroke - fatal or non-fatal embolic stroke associated
with atrial fibrillation. RESULTS: One hundred and sixty-one Thai patients with HCM
(age 66 ± 16 years, 58% female) were enrolled. Forty-two patients (26%) died over a
median follow-up period of 6.8 years including 25 patients (16%) with HCM-related
deaths (2%/year). The HCM-related deaths included: heart failure (52% of HCM-
related deaths; n = 13), SCD (44% of HCM-related deaths; n = 11), and stroke (4% of
HCM-related deaths, n = 1). The SCDs occurred in 6.8% of patients (1%/year).
Eighty-four major MACEs occurred in 65 patients (41, 5%/year). The MACEs included:
40 heart failures in which 2 patients underwent heart transplants; 22 SCDs and
nonfatal ventricular arrhythmias; and 22 fatal or nonfatal strokes. CONCLUSIONS:
The most common mode of death in adult patients with HCM in Thailand was heart
failure followed by SCD. About one-third of the patients experiencing heart failure
died during the 6.8 years of follow-up. SCDs occurred in 7% of patients (1%/year),
predominantly in the fourth decade or later.
AD - Division of Cardiology, Department of Medicine, Faculty of Medicine,
Chulalongkorn University, Rama IV Road, Bangkok, 10330, Thailand.
Cardiac Center, Thai Red Cross Society, King Chulalongkorn Memorial Hospital, Rama
IV Road, Bangkok, 10330, Thailand.
Division of Cardiology, Department of Medicine, Faculty of Medicine, Chulalongkorn
University, Rama IV Road, Bangkok, 10330, Thailand. spuwanant@gmail.com.
Cardiac Center, Thai Red Cross Society, King Chulalongkorn Memorial Hospital, Rama
IV Road, Bangkok, 10330, Thailand. spuwanant@gmail.com.
AN - 30606129
AU - Songsirisuk, N.
AU - Kittipibul, V.
AU - Methachittiphan, N.
AU - Charoenattasil, V.
AU - Zungsontiporn, N.
AU - Spanuchart, I.
AU - Buppajarntham, S.
AU - Mankongpaisarnrung, C.
AU - Satitthummanid, S.
AU - Srimahachota, S.
AU - Chattranukulchai, P.
AU - Boonyaratavej Songmuang, S.
AU - Puwanant, S.
C2 - PMC6318850
DA - Jan 3
DO - 10.1186/s12872-018-0984-0
DP - NLM
ET - 2019/01/05
IS - 1
KW - Adult
Age Factors
Aged
Aged, 80 and over
Cardiomyopathy, Hypertrophic/diagnostic imaging/*mortality/therapy
Cause of Death
Death, Sudden, Cardiac/*epidemiology
Female
Heart Failure/diagnosis/*mortality/therapy
Humans
Male
Middle Aged
Prognosis
Risk Factors
Stroke/mortality
Tachycardia, Ventricular/mortality
Thailand/epidemiology
Time Factors
Ventricular Fibrillation/mortality
Young Adult
*Echocardiography
*Hypertrophic cardiomyopathy
*Outcome
referral center. The study protocol was approved by the University Institutional
Review Board (IRB), Faculty of Medicine, Chulalongkorn University IRB No. 394/60 or
COA No. 827/2017. The IRB was approved by Emeritus Professor Tada Sueblinvong, MD
and Assistant Professor Prapapan Rajatapiti, MD, PhD on September 26, 2017. Not
applicable. This is a retrospective study. CONSENT FOR PUBLICATION: Not applicable.
COMPETING INTERESTS: None. PUBLISHER’S NOTE: Springer Nature remains neutral with
regard to jurisdictional claims in published maps and institutional affiliations.
LA - eng
N1 - 1471-2261
Songsirisuk, Nattakorn
Kittipibul, Veraprapas
Methachittiphan, Nilubon
Charoenattasil, Vorawan
Zungsontiporn, Nath
Spanuchart, Ittikorn
Buppajarntham, Saranya
Mankongpaisarnrung, Charoen
Satitthummanid, Sudarat
Srimahachota, Suphot
Chattranukulchai, Pairoj
Boonyaratavej Songmuang, Smonporn
Puwanant, Sarinya
Orcid: 0000-0001-7090-9947
Journal Article
BMC Cardiovasc Disord. 2019 Jan 3;19(1):1. doi: 10.1186/s12872-018-0984-0.
PY - 2019
SN - 1471-2261
SP - 1
ST - Modes of death and clinical outcomes in adult patients with hypertrophic
cardiomyopathy in Thailand
TI - Modes of death and clinical outcomes in adult patients with hypertrophic
cardiomyopathy in Thailand
VL - 19
ID - 2401
ER -
TY - JOUR
AB - BACKGROUND: Approximately 20% of cerebral infarctions are caused by a cardiac
source of embolism. Although transesophageal echocardiography (TEE) is a valuable
tool for evaluating patients with suspected cardioembolism, its use should be more
selective. OBJECTIVE: We attempted to determine whether risk factors derived from
the clinical, ECG, and transthoracic echocardiogram (TTE) would make TEE use more
selective and increase its yield. METHODS: We retrospectively reviewed the records
of 108 patients with suspected embolic stroke who had undergone TEE evaluation. We
defined the presence of left atrial appendage spontaneous contrast (LAASC), left
atrial appendage thrombus (LAAT), patent foramen ovale (PFO), or intraatrial septal
aneurysm (IASA) as TEE endpoints suggestive of cardioembolism. We evaluated the
association between the TEE endpoints and (1) age greater than 60 years, (2) the
presence of atrial flutter (AFl) or atrial fibrillation (AF) on ECG, (3) left
ventricular (LV) dysfunction by TTE (mild, LVEF < 40%; severe, LVEF < 25%), and (4)
left atrial (LA) size > 4 cm also determined by TTE. The statistical analysis
performed was one-way analysis of variance controlling for interactions between
different risk factors and the endpoints. RESULTS The strongest independent
predictors for the presence of LAASC or LAAT were age greater than 60 years,
presence of AFl/AF, and LV systolic dysfunction. There was no association between
any of the risk factors with the presence of PFO or IASA. CONCLUSION: This study
demonstrates that clinical characteristics, ECG, and TTE findings can help to
better select stroke patients for TEE. Future larger studies are needed to provide
more supporting data.
AN - 12861123
AU - Sorescu, D.
AU - Turk, R. J.
AU - Cain, M.
AU - Lerakis, S.
DA - Jul
DO - 10.1097/00000441-200307000-00005
DP - NLM
ET - 2003/07/16
IS - 1
J2 - The American journal of the medical sciences
KW - Adult
Age Factors
Atrial Fibrillation
Female
Heart Diseases/diagnostic imaging
Humans
Male
Middle Aged
Risk Factors
Stroke/*diagnosis/*diagnostic imaging
Stroke Volume
Thromboembolism/diagnostic imaging
Thrombosis/diagnostic imaging
LA - eng
N1 - Sorescu, Dan
Turk, Rami J
Cain, Marlena
Lerakis, Stamatios
Journal Article
United States
Am J Med Sci. 2003 Jul;326(1):31-4. doi: 10.1097/00000441-200307000-00005.
PY - 2003
SN - 0002-9629 (Print)
0002-9629
SP - 31-4
ST - Clinical and transthoracic echocardiographic predictors of abnormal
transesophageal findings in patients with suspected cardiac source of embolism
T2 - Am J Med Sci
TI - Clinical and transthoracic echocardiographic predictors of abnormal
transesophageal findings in patients with suspected cardiac source of embolism
VL - 326
ID - 2701
ER -
TY - JOUR
AB - BACKGROUND: Prior studies have suggested that patients with acute myocardial
infarction (AMI) who are admitted during off-hours (weekends, nights and holidays)
have higher mortality when compared with patients admitted during regular hours.
METHODS: We analyzed consecutive patients with AMI (ST-elevation myocardial
infarction [STEMI] and non-STEMI) who were treated with percutaneous coronary
interventions from January 1998 to June 2010 at an academic medical center.
Multivariable logistic regression models were used to estimate the association
between off-hour admission and clinical outcomes adjusted for demographic and
clinical variables. RESULTS: There were 3,422 and 2,664 patients with AMI admitted
during off-hours and regular hours, respectively. Patients admitted during off-
hours were more likely to have STEMI (56% vs 48%, P < .001), have cardiogenic shock
at presentation (6% vs 4%, P = .002), and develop shock after presentation (6% vs
5%, P = .004). After multivariable analyses, off-hour admission was not
significantly associated with in-hospital mortality (odds ratio [OR] 1.12, 95% CI
0.84-1.49), 30-day mortality (OR 1.12, 0.87-1.45), or 30-day readmissions (OR 1.01,
0.84-1.20) but was significantly associated with composite major complications and
any of emergent coronary artery bypass graft surgery, ventricular arrhythmia,
stroke/transient ischemic attack, and gastrointestinal/retroperitoneal/intracranial
bleeding (OR 1.27, 1.05-1.55, P = .015). There was no significant time trend in the
adjusted mortality difference between off-hours and regular hours. The results were
not different between STEMI and non-STEMI. CONCLUSIONS: Patients who were admitted
during off-hours did not have higher mortality or readmission rates as compared
with ones admitted during regular hours at an academic medical center.
AD - Division of Preventive Medicine, Mayo Clinic, Rochester, MN. Electronic
address: sorita.atsushi@mayo.edu.
Health Care Policy and Research, and Biomedical Statistics and Informatics, Mayo
Clinic, Rochester, MN.
The Knowledge and Evaluation Research Unit and the Center for the Science of Health
Care Delivery, Mayo Clinic, Rochester, MN.
Division of Pulmonary and Critical Care, Mayo Clinic, Rochester, MN.
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN.
Division of Health Care Policy and Research, Mayo Clinic, Rochester, MN.
Division of Preventive Medicine, Mayo Clinic, Rochester, MN.
AN - 25497249
AU - Sorita, A.
AU - Lennon, R. J.
AU - Haydour, Q.
AU - Ahmed, A.
AU - Bell, M. R.
AU - Rihal, C. S.
AU - Gersh, B. J.
AU - Holmen, J. L.
AU - Shah, N. D.
AU - Murad, M. H.
AU - Ting, H. H.
DA - Jan
DO - 10.1016/j.ahj.2014.08.012
DP - NLM
ET - 2014/12/17
IS - 1
KW - After-Hours Care
Aged
Aged, 80 and over
Female
Hospital Mortality
Humans
Logistic Models
Male
Middle Aged
Myocardial Infarction/*mortality/*therapy
*Outcome and Process Assessment, Health Care
*Percutaneous Coronary Intervention
Shock, Cardiogenic
LA - eng
N1 - 1097-6744
Sorita, Atsushi
Lennon, Ryan J
Haydour, Qusay
Ahmed, Adil
Bell, Malcolm R
Rihal, Charanjit S
Gersh, Bernard J
Holmen, Jody L
Shah, Nilay D
Murad, Mohammad Hassan
Ting, Henry H
Journal Article
United States
Am Heart J. 2015 Jan;169(1):62-8. doi: 10.1016/j.ahj.2014.08.012. Epub 2014 Sep 16.
PY - 2015
SN - 0002-8703
SP - 62-8
ST - Off-hour admission and outcomes for patients with acute myocardial infarction
undergoing percutaneous coronary interventions
T2 - Am Heart J
TI - Off-hour admission and outcomes for patients with acute myocardial infarction
undergoing percutaneous coronary interventions
VL - 169
ID - 3134
ER -
TY - JOUR
AB - Cardiac arrests at two acute hospitals were investigated over a 5-month
period. The outcome expressed as short-term and long-term survival was correlated
with diagnosis, age, sex and technical details of the resuscitation. Survivors were
followed up for 3 months to detect any remaining cerebral deficit. Of 108 patients
who suffered cardiac arrest, 23 (21.3%) survived to be discharged from hospital, 58
(53.7%) died immediately and 27 (25%) survived for periods ranging from 1 hour to
30 days following cardiac arrest, before eventual death. Evidence of cerebral
impairment was present initially in three patients (2.7%) at discharge from
hospital. After 3 months however cerebral impairment was present in only one
patient (0.9%). Survival was highest in patients suffering ventricular fibrillation
following myocardial infarction where 16 out of 35 (47%) survived. Certain groups
of patients were identified where the ultimate survival was predictably nil.
Although some survived for short periods it was concluded that the attempted
resuscitation in these patients was inappropriate and unjustified.
AN - 6364883
AU - Sowden, G. R.
AU - Robins, D. W.
AU - Baskett, P. J.
DA - Jan
DO - 10.1111/j.1365-2044.1984.tb09452.x
DP - NLM
ET - 1984/01/01
IS - 1
J2 - Anaesthesia
KW - Adolescent
Adult
Aged
Brain Diseases/*etiology
Cognition Disorders/etiology
Female
Heart Arrest/complications/*mortality
Humans
Male
Middle Aged
Resuscitation
Time Factors
LA - eng
N1 - Sowden, G R
Robins, D W
Baskett, P J
Case Reports
Journal Article
England
Anaesthesia. 1984 Jan;39(1):39-43. doi: 10.1111/j.1365-2044.1984.tb09452.x.
PY - 1984
SN - 0003-2409 (Print)
0003-2409
SP - 39-43
ST - Factors associated with survival and eventual cerebral status following
cardiac arrest
T2 - Anaesthesia
TI - Factors associated with survival and eventual cerebral status following
cardiac arrest
VL - 39
ID - 2981
ER -
TY - JOUR
AB - BACKGROUND: Aortic valve calcification patterns were associated with short-
and long-term outcomes in previous small observational datasets of patients
undergoing transcatheter aortic valve implantation (TAVI). The specific impact of
multi detector-row computed tomography (MDCT) findings on outcomes in women has not
been reported. We sought to describe the associations between MDCT characteristics
and clinical outcomes in a registry of 547 women undergoing TAVI. METHODS: WIN-TAVI
is the first all-female registry to study the safety and effectiveness of TAVI in
women (n = 1019). Thirteen sites participated in the MDCT sub-study and contributed
pre-TAVI MDCT studies in 547 consecutive subjects. All MDCT data were analyzed in
an independent core lab blinded to clinical outcomes. Key measurements included
number of valve leaflets, aortic annulus area and perimeter, left and right
coronary artery height, aortic cusp calcium volume, commissural calcification and
left ventricular outflow tract (LVOT) calcification. Calcium volume of the aortic
valvular complex was quantified using a threshold relative to patient-specific
contrast attenuation in the arterial blood pool. We examined univariate and
multivariate associations between ECG-gated contrast MDCT characteristics and 1-
year mortality or stroke, new pacemaker implantation and new onset atrial
fibrillation (AF). RESULTS: The CT sub-study sample had a mean age of 82.8 ± 6.3
years, mean logistic EuroSCORE of 17.8 ± 11.3%, and mean STS score of 8.2 ± 7.4%.
Transfemoral access was used in 89.6% of patients. After multivariate adjustment,
moderate or severe LVOT calcification was an independent predictor of 1-year
mortality or stroke (HR = 1.91; 95% CI: 1.11-3.30; p = 0.02). Calcium volume in the
right coronary cusp was an independent predictor of new pacemaker (HR = 1.18 per
100 m(3) increment; p = 0.04), whereas calcium volume of the non-coronary cusp had
a protective effect (HR = 0.78 per 100 mm(3) increment; p = 0.004). Severe
calcification of the non-coronary/right-coronary commissure was an independent
predictor of new AF (HR = 5.1; p = 0.008). CONCLUSION: Computed tomography provides
important prognostic information in women undergoing TAVI. Moderate or severe LVOT
calcification is associated to an almost two-fold increased risk of mortality or
stroke at one year. Different calcification patterns of the aortic valve may
predict diverse rhythm abnormalities.
AD - Department of Cardiology, Institut Hospitalier Jacques Cartier, Ramsay
générale de santé, Massy, France; Department of Cardiology, McGill University
Health Centre, Royal-Victoria Hospital, Montréal, Canada. Electronic address:
marco.spaziano@mcgill.ca.
Department of Cardiology, San Raffaele Scientific Institute, Milan, Italy.
Department of Cardiology, Teikyo University School of Medicine, Tokyo, Japan.
The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine
at Mont Sinai, New York, USA.
Department of Cardiology, Institut Hospitalier Jacques Cartier, Ramsay générale de
santé, Massy, France.
Department of Cardiology, AOUP Cisanello, University Hospital, Pisa, Italy.
Department of Cardiology, Istituto Clinico Humanitas, Milan, Italy.
Department of Cardiology, Clinique Pasteur, Toulouse, France.
Department of Cardiology, Azienda Ospidaliera Universitaria Senese, Policlinico Le
Scotte, Siena, Italy.
Department of Cardiology, Erasmus Medical Center, Thoraxcenter, Rotterdam, The
Netherlands.
Department of Cardiology, Ludwig-Maximilians-University of Munich, Munich, Germany.
AN - 29735255
AU - Spaziano, M.
AU - Chieffo, A.
AU - Watanabe, Y.
AU - Chandrasekhar, J.
AU - Sartori, S.
AU - Lefèvre, T.
AU - Petronio, A. S.
AU - Presbitero, P.
AU - Tchetche, D.
AU - Iadanza, A.
AU - Van Mieghem, N. M.
AU - Mehilli, J.
AU - Mehran, R.
AU - Morice, M. C.
DA - Jul-Aug
DO - 10.1016/j.jcct.2018.04.007
DP - NLM
ET - 2018/05/08
IS - 4
J2 - Journal of cardiovascular computed tomography
KW - Aged
Aged, 80 and over
Aortic Valve/*diagnostic
imaging/*pathology/physiopathology/surgery/*transplantation
Aortic Valve Stenosis/*diagnostic imaging/mortality/physiopathology/*surgery
Arrhythmias, Cardiac/*epidemiology/mortality/therapy
Calcinosis/*diagnostic imaging/mortality/physiopathology/*surgery
Europe/epidemiology
Female
Humans
Incidence
Logistic Models
*Multidetector Computed Tomography
North America/epidemiology
Registries
Risk Factors
Stroke/*epidemiology/mortality
Time Factors
Transcatheter Aortic Valve Replacement/*adverse effects/mortality
Treatment Outcome
Ventricular Outflow Obstruction/diagnostic imaging/mortality/physiopathology
*Women's Health
Multi-slice computed tomography
Outcomes
Transcatheter aortic valve replacement
Women
LA - eng
N1 - 1876-861x
Spaziano, Marco
Chieffo, Alaide
Watanabe, Yusuke
Chandrasekhar, Jaya
Sartori, Samantha
Lefèvre, Thierry
Petronio, Anna Sonia
Presbitero, Patrizia
Tchetche, Didier
Iadanza, Alessandro
Van Mieghem, Nicholas M
Mehilli, Julinda
Mehran, Roxana
Morice, Marie-Claude
WIN-TAVI Investigators
Journal Article
Multicenter Study
Observational Study
United States
J Cardiovasc Comput Tomogr. 2018 Jul-Aug;12(4):338-343. doi:
10.1016/j.jcct.2018.04.007. Epub 2018 Apr 27.
PY - 2018
SN - 1876-861x
SP - 338-343
ST - Computed tomography predictors of mortality, stroke and conduction
disturbances in women undergoing TAVR: A sub-analysis of the WIN-TAVI registry
T2 - J Cardiovasc Comput Tomogr
TI - Computed tomography predictors of mortality, stroke and conduction
disturbances in women undergoing TAVR: A sub-analysis of the WIN-TAVI registry
VL - 12
ID - 2293
ER -
TY - JOUR
AB - 27 of 101 patients with complex ventricular ectopy (ventricular bigeminy,
couplets, ventricular salvo and ventricular tachycardia) during 24-hour Holter
monitoring died during a mean follow-up of 12 months. Mortality was 28% when
ventricular salvos had been detected, and 43% in patients with ventricular
tachycardia. Detection of ventricular bigeminy had no, registration of ventricular
couplets little prognostic significance. Prognosis was altered by presence of
cerebral symptoms (dizziness and/or syncope) only for patients with ventricular
tachycardia: additional bradyarrhythmia (asystole longer than 1.5 sec due to sinus-
atrial or atrioventricular block) did not effect the prognosis, which was
significantly worse for patients with a history of myocardial infarction, although
patients in the first year after acute myocardial infarction were not included in
this study. Prognosis of complex ventricular ectopy significantly worsens with age,
it seems of little prognostic significance for patients under the age of 60.
AN - 7046274
AU - Spielberg, C.
AU - von Leitner, E. R.
AU - Andresen, D.
AU - Schröder, R.
DA - Apr
DP - NLM
ET - 1982/04/01
IS - 4
KW - Adult
Age Factors
Aged
Bradycardia/diagnosis/mortality
Female
Heart Arrest/diagnosis
Humans
Male
Middle Aged
Myocardial Infarction/mortality/rehabilitation
Prognosis
Syncope/etiology
Tachycardia/*diagnosis/mortality
LA - ger
N1 - Spielberg, C
von Leitner, E R
Andresen, D
Schröder, R
English Abstract
Journal Article
Germany
Z Kardiol. 1982 Apr;71(4):271-7.
OP - Prognostiche Bedeutung komplexer tachykarder ventrikulärer Rhythmusstörungen
im 24-Stunden-Langzeit-EKG.
PY - 1982
SN - 0300-5860 (Print)
0300-5860
SP - 271-7
ST - [Prognostic significance of complex ventricular ectopy in 24-hour ambulatory
electrocardiographic monitoring (author's transl)]
T2 - Z Kardiol
TI - [Prognostic significance of complex ventricular ectopy in 24-hour ambulatory
electrocardiographic monitoring (author's transl)]
VL - 71
ID - 2614
ER -
TY - JOUR
AB - Electrical storm is defined as a recurrent episode of hemodynamically
destabilizing ventricular tachyarrhythmia that usually requires electrical
cardioversion or defibrillation. We describe three cases presenting with electrical
storm under differing circumstances: (1) a 57-year-old man with ST-elevation
myocardial infarction within 1 week of a posterior circulation stroke who developed
refractory sustained ventricular tachycardia 10 days after an acute myocardial
infarction; (2) a 65-year-old man who developed polymorphic ventricular tachycardia
and ventricular fibrillation following dobutamine echocardiography; and (3) a 20-
year-old woman who developed intractable ventricular fibrillation following an
overdose of a weight-reduction pill. The management of electrical storm is
discussed, and evolving literature supporting the routine use of intravenous
amiodarone and beta-blockers in place of intravenous lidocaine is critically
examined.
AD - Department of Cardiology, West Los Angeles VA Medical Center and Department
of Cardiology, Olive View Medical Center, Sylmar, UCLA School of Medicine, Los
Angeles, California 90073, USA.
AN - 14506549
AU - Srivatsa, U. N.
AU - Ebrahimi, R.
AU - El-Bialy, A.
AU - Wachsner, R. Y.
DA - Sep
DO - 10.1177/107424840300800309
DP - NLM
ET - 2003/09/25
IS - 3
J2 - Journal of cardiovascular pharmacology and therapeutics
Adult
Aged
Amiodarone/*administration & dosage/therapeutic use
Anti-Arrhythmia Agents/*administration & dosage/therapeutic use
Anti-Obesity Agents/poisoning
Brain Infarction/complications
Death, Sudden, Cardiac
Echocardiography, Stress/adverse effects
Electrocardiography
Female
Humans
Lidocaine/administration & dosage/therapeutic use
Male
Middle Aged
Synephrine/poisoning
Tachycardia, Ventricular/*drug therapy/etiology/therapy
Ventricular Fibrillation/*drug therapy/etiology/therapy
LA - eng
N1 - Srivatsa, Uma N
Ebrahimi, Ramin
El-Bialy, Adel
Wachsner, Robin Y
Case Reports
Journal Article
United States
J Cardiovasc Pharmacol Ther. 2003 Sep;8(3):237-46. doi: 10.1177/107424840300800309.
PY - 2003
SN - 1074-2484 (Print)
1074-2484
SP - 237-46
ST - Electrical storm: case series and review of management
T2 - J Cardiovasc Pharmacol Ther
TI - Electrical storm: case series and review of management
VL - 8
ID - 2778
ER -
TY - JOUR
AB - Two cases of abuse of bromochlorodifluoromethane (BCF - a fire-extinguishing
agent) by inhalation are reported. In the first case, a 15-year-old youth presented
in ventricular fibrillation; the second youth was dead on arrival at hospital.
Port-mortem toxicological investigations confirmed BCF inhalation in the latter
patient. Management of the surviving patient included cardioversion, controlled
mandatory hyperventilation, intravenous infusions of mannitol, and barbiturate
protection against cerebral ischaemia. He had completely recovered after eight
days. Community agencies report that BCF inhalation occurs frequently on the Gold
Coast, Queensland. This behaviour can be associated with sudden death from
ventricular arrhythmias after cardiac sensitization to endogenous adrenaline. The
"lone sniffer" is at greatest risk, and identification of such individuals may
prevent a fatal outcome.
AN - 6738424
AU - Steadman, C.
AU - Dorrington, L. C.
AU - Kay, P.
AU - Stephens, H.
DA - Jul 21
DP - NLM
ET - 1984/07/21
IS - 2
J2 - The Medical journal of Australia
KW - Adolescent
Brain Ischemia/chemically induced/therapy
Bromochlorofluorocarbons
*Chlorofluorocarbons, Methane/poisoning
Fire Extinguishing Systems
Humans
Male
Substance-Related Disorders/*complications
Ventricular Fibrillation/chemically induced/therapy
LA - eng
N1 - Steadman, C
Dorrington, L C
Kay, P
Stephens, H
Case Reports
Journal Article
Australia
Med J Aust. 1984 Jul 21;141(2):115-7.
PY - 1984
SN - 0025-729X (Print)
0025-729x
SP - 115-7
ST - Abuse of a fire-extinguishing agent and sudden death in adolescents
T2 - Med J Aust
TI - Abuse of a fire-extinguishing agent and sudden death in adolescents
VL - 141
ID - 2891
ER -
TY - JOUR
AB - PURPOSE OF REVIEW: Atrial fibrillation (AF) and heart failure (HF) commonly
coexist and are associated with an increased risk of hospitalization, morbidity,
and mortality. Both conditions develop into epidemics due to the ageing of the
population and lead to poorer prognosis for the individual patients. Therapeutic
strategies include treatment with oral anticoagulation, and rate and rhythm control
concepts to prevent stroke and improve the cardiovascular outcome. RECENT FINDINGS:
Especially in HF patients, data suggest that catheter ablation of AF is superior to
medical treatment. In patients with both AF and HF undergoing catheter ablation,
significant increases in left ventricular ejection fraction and quality of life and
decreases in related symptoms and major adverse cardiac events are reported. In
addition, catheter ablation has been shown to reduce mortality and HF
hospitalization in the medium term. For patients with AF and HF, an effective
individualized therapeutic strategy to minimize potential complications and improve
clinical outcomes is needed. Catheter ablation of AF seems to provide advantages in
HF patients with AF. However, results of further long-term studies are awaited.
AD - Department of Electrophysiology, Heart Center Leipzig at University of
Leipzig, Leipzig, Germany. clara.stegmann@gmx.de.
Department of Electrophysiology, Heart Center Leipzig at University of Leipzig,
Leipzig, Germany.
AN - 31144245
AU - Stegmann, C.
AU - Hindricks, G.
DA - Aug
DO - 10.1007/s11897-019-00430-5
DP - NLM
ET - 2019/05/31
IS - 4
J2 - Current heart failure reports
Atrial Fibrillation/diagnosis/*therapy
*Catheter Ablation
Heart Failure/diagnosis/*therapy
Hospitalization
Humans
Prognosis
Quality of Life
Stroke Volume
Treatment Outcome
*Heart failure
*Rate control
*Rhythm control
LA - eng
N1 - 1546-9549
Stegmann, Clara
Hindricks, Gerhard
Journal Article
Review
United States
Curr Heart Fail Rep. 2019 Aug;16(4):108-115. doi: 10.1007/s11897-019-00430-5.
PY - 2019
SN - 1546-9530
SP - 108-115
ST - Atrial Fibrillation in Heart Failure-Diagnostic, Therapeutic, and Prognostic
Relevance
T2 - Curr Heart Fail Rep
TI - Atrial Fibrillation in Heart Failure-Diagnostic, Therapeutic, and Prognostic
Relevance
VL - 16
ID - 2367
ER -
TY - JOUR
AB - BACKGROUND: The prognosis for patients aged over 75 years who receive a
pacemaker in the context of sinus node dysfunction is unclear. AIMS: We sought to
evaluate the incidences of atrial fibrillation, heart failure and death in such
patients, and the role of the pacing mode in their prognosis. METHODS: This was a
retrospective study of 102 patients aged over 75 years (mean 82.2 ± 4.4 years) who
received a pacemaker in the context of sinus node dysfunction. RESULTS: During the
follow-up period (mean 806 days), 36 patients (35.3%) experienced heart failure, 47
patients (46.1%) had an episode of paroxysmal atrial fibrillation, 19 patients
(18.6%) progressed to chronic atrial fibrillation and 29 (28.4%) died, the fatal
event being sudden death or of cardiac origin in almost half of these patients
(44.8%). Patients assigned to dual-chamber minimal ventricular pacing showed
significantly lower rates of heart failure episodes (P=0.023) and all-cause
mortality (P<0.001) than those assigned to conventional dual-chamber pacing. In
contrast, the two groups did not differ with regard to either paroxysmal or chronic
atrial fibrillation. CONCLUSION: In patients aged over 75 years, the use of dual-
chamber pacemakers incorporating an algorithm minimizing ventricular pacing for
sinus node dysfunction seems to decrease the number of heart failure episodes and
mortality. On the basis of this finding, the implantation of such devices seems
justifiable, even in this age group.
AD - Department of cardiology, centre hospitalier de Haguenau, 64, avenue du Pr
Leriche, 67504 Haguenau cedex, France. mathieu.steinbach@ch-haguenau.fr
AN - 21402343
AU - Steinbach, M.
AU - Douchet, M. P.
AU - Bakouboula, B.
AU - Bronner, F.
AU - Chauvin, M.
DA - Feb
DO - 10.1016/j.acvd.2010.11.006
DP - NLM
ET - 2011/03/16
IS - 2
KW - Age Factors
Aged
Aged, 80 and over
*Aging
Atrial Fibrillation/etiology/prevention & control
*Cardiac Pacing, Artificial/adverse effects/mortality
Death, Sudden, Cardiac/etiology/prevention & control
Equipment Design
Female
Humans
Male
Patient Selection
Risk Assessment
Risk Factors
Sick Sinus Syndrome/mortality/physiopathology/*therapy
Survival Analysis
Time Factors
Treatment Outcome
LA - eng
N1 - 1875-2128
Steinbach, Mathieu
Douchet, Marie-Pierre
Bakouboula, Babe
Bronner, François
Chauvin, Michel
Journal Article
Netherlands
Arch Cardiovasc Dis. 2011 Feb;104(2):89-96. doi: 10.1016/j.acvd.2010.11.006. Epub
2011 Jan 22.
PY - 2011
SN - 1875-2128
SP - 89-96
ST - Outcome of patients aged over 75 years who received a pacemaker to treat
sinus node dysfunction
TI - Outcome of patients aged over 75 years who received a pacemaker to treat
sinus node dysfunction
VL - 104
ID - 2688
ER -
TY - JOUR
AB - BACKGROUND: Most patients with atrial fibrillation (AF) require rate control;
however, the optimal target heart rate remains under debate. We aimed to assess
rate control and subsequent outcomes among patients with permanent AF. METHODS AND
RESULTS: We studied 2812 US outpatients with permanent AF in the Outcomes Registry
for Better Informed Treatment of Atrial Fibrillation. Resting heart rate was
measured longitudinally and used as a time-dependent covariate in multivariable Cox
models of all-cause and cause-specific mortality during a median follow-up of 24
months. At baseline, 7.4% (n=207) had resting heart rate <60 beats per minute
(bpm), 62% (n=1755) 60 to 79 bpm, 29% (n=817) 80 to 109 bpm, and 1.2% (n=33) ≥110
bpm. Groups did not differ by age, previous cerebrovascular disease, heart failure
status, CHA2DS2-VASc scores, renal function, or left ventricular function. There
were significant differences in race (P=0.001), sinus node dysfunction (P=0.004),
and treatment with calcium-channel blockers (P=0.006) and anticoagulation
(P=0.009). In analyses of continuous heart rates, lower heart rate ≤65 bpm was
associated with higher all-cause mortality (adjusted hazard ratio [HR], 1.15 per 5-
bpm decrease; 95% CI, 1.01 to 1.32; P=0.04). Similarly, increasing heart rate >65
bpm was associated with higher all-cause mortality (adjusted HR, 1.10 per 5-bpm
increase; 95% CI, 1.05 to 1.15; P<0.0001). This relationship was consistent across
endpoints and in a broader sensitivity analysis of permanent and nonpermanent AF
patients. CONCLUSIONS: Among patients with permanent AF, there is a J-shaped
relationship between heart rate and mortality. These data support current guideline
recommendations, and clinical trials are warranted to determine optimal rate
control. CLINICAL TRIAL REGISTRATION: URL: http://clinicaltrials.gov/. Unique
AD - Duke University Medical Center, Durham, NC (B.A.S., E.D.P., J.P.P.) Duke
Clinical Research Institute, Durham, NC (B.A.S., S.K., L.T., F.H., E.D.P., J.P.P.).
Duke Clinical Research Institute, Durham, NC (B.A.S., S.K., L.T., F.H., E.D.P.,
J.P.P.).
UCLA Division of Cardiology, Los Angeles, CA (G.C.F.).
Mayo Clinic, Rochester, MN (B.J.G.).
Boston University School of Medicine, Boston, MA (E.H.).
Lankenau Institute for Medical Research, Wynnewood, PA (P.R.K.).
Stanford University School of Medicine, Palo Alto, CA (K.W.M.).
Penn State University School of Medicine, Hershey, PA (G.N.).
Columbia University College of Physicians and Surgeons, New York, NY (J.A.R.).
Janssen Pharmaceuticals, Inc., Raritan, NJ (P.C.).
AN - 26370445
AU - Steinberg, B. A.
AU - Kim, S.
AU - Thomas, L.
AU - Fonarow, G. C.
AU - Gersh, B. J.
AU - Holmqvist, F.
AU - Hylek, E.
AU - Kowey, P. R.
AU - Naccarelli, G.
AU - Reiffel, J. A.
AU - Chang, P.
AU - Peterson, E. D.
AU - Piccini, J. P.
C2 - PMC4599492
DA - Sep 14
DO - 10.1161/jaha.115.002031
DP - NLM
ET - 2015/09/16
IS - 9
KW - Aged
Aged, 80 and over
Atrial Fibrillation/diagnosis/*drug therapy/*mortality/physiopathology
Female
Humans
Male
Prospective Studies
Registries
Risk Assessment
Risk Factors
Time Factors
Treatment Outcome
atrial fibrillation
heart rate
outcomes
rate control
LA - eng
N1 - 2047-9980
Steinberg, Benjamin A
Kim, Sunghee
Thomas, Laine
Fonarow, Gregg C
Gersh, Bernard J
Holmqvist, Fredrik
Hylek, Elaine
Kowey, Peter R
Mahaffey, Kenneth W
Naccarelli, Gerald
Reiffel, James A
Chang, Paul
Peterson, Eric D
Piccini, Jonathan P
Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT‐AF)
Investigators and Patients
5 T32 HL 7101-38/HL/NHLBI NIH HHS/United States
Journal Article
Observational Study
J Am Heart Assoc. 2015 Sep 14;4(9):e002031. doi: 10.1161/JAHA.115.002031.
PY - 2015
SN - 2047-9980 (Print)
2047-9980
SP - e002031
ST - Increased Heart Rate Is Associated With Higher Mortality in Patients With
Atrial Fibrillation (AF): Results From the Outcomes Registry for Better Informed
Treatment of AF (ORBIT-AF)
TI - Increased Heart Rate Is Associated With Higher Mortality in Patients With
Atrial Fibrillation (AF): Results From the Outcomes Registry for Better Informed
Treatment of AF (ORBIT-AF)
VL - 4
ID - 2965
ER -
TY - JOUR
AB - Left ventricular hypertrophy (LVH) was one of the earliest studied
echocardiographic characteristics of the left ventricle. As the myriad of
measurable metrics has multiplied over recent years, this reliable and relevant
variable can often be overlooked. In this paper, we discuss appropriate techniques
for accurate analysis, underlying pathophysiology, and the contributions from
various risk factors. The prognostic implications of LVH on stroke, serious
arrhythmias, and sudden cardiac death are reviewed. Finally, we examine the effect
of therapy to reduce LVH and the resultant clinical outcomes.
AD - John Ochsner Heart and Vascular Institute, Ochsner Clinical School- The
University of Queensland School of Medicine, New Orleans, LA, United States of
America. Electronic address: Merrill.stewart@ochsner.org.
John Ochsner Heart and Vascular Institute, Ochsner Clinical School- The University
of Queensland School of Medicine, New Orleans, LA, United States of America.
AN - 30408469
AU - Stewart, M. H.
AU - Lavie, C. J.
AU - Shah, S.
AU - Englert, J.
AU - Gilliland, Y.
AU - Qamruddin, S.
AU - Dinshaw, H.
AU - Cash, M.
AU - Ventura, H.
AU - Milani, R.
DA - Nov-Dec
DO - 10.1016/j.pcad.2018.11.002
DP - NLM
ET - 2018/11/09
IS - 5-6
J2 - Progress in cardiovascular diseases
KW - Arrhythmias, Cardiac/diagnostic imaging/*etiology/physiopathology/therapy
Echocardiography
Humans
Hypertrophy, Left Ventricular/*complications/diagnostic
imaging/physiopathology/therapy
Prognosis
Risk Factors
Stroke/diagnostic imaging/*etiology/physiopathology/therapy
*Cardiovascular disease
*Echocardiography
*Hypertension
*Left ventricle
*Left ventricular geometry
*Left ventricular hypertrophy
*Left ventricular mass
LA - eng
N1 - 1873-1740
Stewart, Merrill H
Lavie, Carl J
Shah, Sangeeta
Englert, Joseph
Gilliland, Yvonne
Qamruddin, Salima
Dinshaw, Homeyar
Cash, Michael
Ventura, Hector
Milani, Richard
Journal Article
Review
United States
Prog Cardiovasc Dis. 2018 Nov-Dec;61(5-6):446-455. doi: 10.1016/j.pcad.2018.11.002.
Epub 2018 Nov 6.
PY - 2018
SN - 0033-0620
SP - 446-455
ST - Prognostic Implications of Left Ventricular Hypertrophy
T2 - Prog Cardiovasc Dis
TI - Prognostic Implications of Left Ventricular Hypertrophy
VL - 61
ID - 2283
ER -
TY - JOUR
AB - Serotonin (5-hydroxytryptamine)(1B/1D) agonists can vasoconstrict coronary
and cerebral arteries. Chest, jaw, and arm discomfort, so-called "triptan
sensations," are often felt to be noncardiac. In Part 1 of this review, the
relationship of triptans, coronary artery narrowing, and spasm was discussed, along
with a case of a 53-year-old woman without cardiac risk factors who developed
polymorphic ventricular tachycardia and cardiac ischemia with acquired corrected QT
(QTc) interval prolongation following oral sumatriptan. In Part 2 of this review,
headache medications, drug-drug interactions, QTc prolongation, and cardiac
arrhythmias are appraised and discussed. Triptans, cardiac arrhythmias, and
ischemia by prescribing information are summarized. The reader is provided tables
on QTc prolongation by medication. The problem of QTc prolongation with a variety
of headache medications at conventional doses, including triptans, serotonin
reuptake inhibitors (selective serotonin reuptake inhibitors and serotonin
norepinephrine reuptake inhibitors), other antidepressants, antihistamines, and
antinauseants should lead to proactively obtaining electrocardiograms and more
vigilant surveillance of headache patients. This may be the place to start in
protecting patients from these cardiac adverse events.
AD - Headache Center, Neurological Institute, Cleveland Clinic, Cleveland, OH,
USA.
Department of Cardiology, Cleveland Clinic, Cleveland, OH, USA.
AN - 23216298
AU - Stillman, M. J.
AU - Tepper, D. E.
AU - Tepper, S. J.
AU - Cho, L.
DA - Jan
DO - 10.1111/j.1526-4610.2012.02299.x
DP - NLM
ET - 2012/12/12
IS - 1
J2 - Headache
KW - Arrhythmias, Cardiac/chemically induced
Coronary Vasospasm/chemically induced
*Drug Interactions
Female
Headache/*drug therapy
Humans
Middle Aged
Myocardial Ischemia/chemically induced
Serotonin Receptor Agonists/*adverse effects
Torsades de Pointes/chemically induced
LA - eng
N1 - 1526-4610
Stillman, Mark J
Tepper, Deborah E
Tepper, Stewart J
Cho, Leslie
Case Reports
Journal Article
Review
United States
Headache. 2013 Jan;53(1):217-224. doi: 10.1111/j.1526-4610.2012.02299.x. Epub 2012
Dec 6.
PY - 2013
SN - 0017-8748
SP - 217-224
ST - QT prolongation, Torsade de Pointes, myocardial ischemia from coronary
vasospasm, and headache medications. Part 2: review of headache medications, drug-
drug interactions, QTc prolongation, and other arrhythmias
T2 - Headache
TI - QT prolongation, Torsade de Pointes, myocardial ischemia from coronary
vasospasm, and headache medications. Part 2: review of headache medications, drug-
drug interactions, QTc prolongation, and other arrhythmias
VL - 53
ID - 2871
ER -
TY - JOUR
AB - Serotonin (5-hydroxytryptamine)(1B/1D) agonists are vasoconstrictors that can
affect coronary and cerebral arteries. Retrosternal chest, arm, and jaw pain
following triptan use is generally attributed to "triptan sensations" and dismissed
as noncardiac. However, triptans narrow normal coronary arteries and occasionally
trigger vasospasm. They are contraindicated in atherosclerotic vascular disease.
Part 1 of this review examines the relationship of medications used in migraine
with the likelihood of causing vasospasm or vasoconstriction, and the triggering of
cardiac arrhythmias. We report an illustrative case of polymorphic ventricular
tachyarrhythmia, electrocardiogram changes consistent with cardiac ischemia, and
acquired corrected QT interval lengthening following oral sumatriptan in a 53-year-
old migraineur without risk factors for coronary artery disease (CAD). Extensive
evaluation revealed insignificant single coronary vessel atherosclerosis and
coronary artery vasospasm on ergonovine challenge. The report highlights the hidden
risk that may underlie a "triptan sensation" and the possible association of the
vasospastic features of Raynaud's phenomenon, migraine headaches, and coronary
vasospasm. Part 1 discusses the risks for Torsade de Pointes, vasospasm, and
ischemia, with a review and discussion of case reports of triptan-associated
cardiovascular events in migraineurs with and without CAD risk factors or
documented CAD; of the epidemiology and studies of triptans, vasospasm, and
cardiovascular morbidity; and of the relationship of variant angina, migraine, and
vasospastic disease. In the second part of this review, headache medications and
their propensity for corrected QT prolongation will be summarized.
AD - Headache Center, Neurological Institute, Cleveland Clinic, Cleveland, OH,
USA.
Department of Cardiology, Cleveland Clinic, Cleveland, OH, USA.
AN - 23216317
AU - Stillman, M. J.
AU - Tepper, S.
AU - Tepper, D. E.
AU - Cho, L.
DA - Jan
DO - 10.1111/j.1526-4610.2012.02300.x
DP - NLM
ET - 2012/12/12
IS - 1
J2 - Headache
KW - Coronary Vasospasm/*chemically induced
Electrocardiography
Female
Humans
Middle Aged
Migraine Disorders/*drug therapy
Myocardial Ischemia/*chemically induced
Serotonin Receptor Agonists/*adverse effects
Sumatriptan/*adverse effects
Torsades de Pointes/*chemically induced
LA - eng
N1 - 1526-4610
Stillman, Mark J
Tepper, Stewart
Tepper, Deborah E
Cho, Leslie
Case Reports
Journal Article
Review
United States
Headache. 2013 Jan;53(1):208-216. doi: 10.1111/j.1526-4610.2012.02300.x. Epub 2012
Dec 6.
PY - 2013
SN - 0017-8748
SP - 208-216
ST - QT prolongation, Torsade de Pointes, myocardial ischemia from coronary
vasospasm, and headache medications. Part 1: review of serotonergic cardiac adverse
events with a triptan case
T2 - Headache
TI - QT prolongation, Torsade de Pointes, myocardial ischemia from coronary
vasospasm, and headache medications. Part 1: review of serotonergic cardiac adverse
events with a triptan case
VL - 53
ID - 3031
ER -
TY - JOUR
AB - BACKGROUND: Patients with atrial fibrillation (AF) have a higher mortality
and risk of stroke/embolism than patients with sinus rhythm. HYPOTHESIS: The aim of
the study was to assess the association of clinical and echocardiographic
characteristics with mortality and stroke/embolism and the use of antithrombotic
medication in the year 2000 in patients who participated 1990-1995 in the Embolism
in Left Atrial Thrombi (ELAT) study. METHODS: The study included 409 outpatients
with nonrheumatic AF (62 +/- 12 years, 36% women, 39% intermittent AF). Patients
with thrombi received anticoagulation, patients without thrombi aspirin until
follow-up in 1995; thereafter, anticoagulation according to clinical risk factors
was recommended. Primary events were death and secondary events were
stroke/embolism. All patients were contacted during the year 2000. RESULTS: Mean
follow-up was 102 months. Mortality was 4%/year; the cause of death was cardiac (n
= 84), fatal stroke (n = 26), malignancy (n = 23), sepsis (n = 5), and unknown (n =
24). Multivariate analysis identified age (p < 0.0001), heart failure (p = 0.0013),
and reduced left ventricular systolic function (p = 0.0353) as predictors of
mortality. Stroke/embolism occurred in 83 patients, with a rate of 3%/year.
Multivariate analysis identified age (p = 0.0006) and previous stroke (p = 0.0454)
as predictors of stroke/embolism. In the year 2000, 51 (21%) of the 247 surviving
patients received no antithrombotic medication, 88 received (36%) oral
anticoagulants, 102 (41%) acetylsalicylic acid, and 6 (2%) low-molecular heparin.
CONCLUSIONS: Therapy for heart failure and oral anticoagulation in AF should be
seriously considered, especially in elderly patients and in those with previous
stroke.
AD - Second Medical Department, KA Rudolfstiftung, Vienna, Austria.
claudia.stoellberger@chello.at
AN - 14743856
AU - Chnupa, P.
AU - Abzieher, C.
AU - Länger, T.
AU - Finsterer, J.
AU - Klem, I.
AU - Hartl, E.
AU - Wehinger, C.
AU - Schneider, B.
C2 - PMC6654077
DA - Jan
DO - 10.1002/clc.4960270111
DP - NLM
ET - 2004/01/28
IS - 1
KW - Age Factors
Aged
Atrial Fibrillation/complications/*drug therapy/*mortality
Female
Follow-Up Studies
Heparin, Low-Molecular-Weight/therapeutic use
Humans
Male
Middle Aged
Prospective Studies
Stroke/etiology/*mortality
Thromboembolism/diagnostic imaging/etiology/*prevention & control
LA - eng
N1 - 1932-8737
Chnupa, Pavel
Abzieher, Christine
Länger, Thomas
Finsterer, Josef
Klem, Igor
Hartl, Elisabeth
Wehinger, Cornelius
Schneider, Barbara
Journal Article
Multicenter Study
Clin Cardiol. 2004 Jan;27(1):40-6. doi: 10.1002/clc.4960270111.
PY - 2004
SN - 0160-9289 (Print)
0160-9289
SP - 40-6
ST - Mortality and rate of stroke or embolism in atrial fibrillation during long-
term follow-up in the embolism in left atrial thrombi (ELAT) study
T2 - Clin Cardiol
TI - Mortality and rate of stroke or embolism in atrial fibrillation during long-
term follow-up in the embolism in left atrial thrombi (ELAT) study
VL - 27
ID - 2396
ER -
TY - JOUR
AB - Mitral regurgitation (MR) is one of the most prevalent valve disorders and
has numerous aetiologies, including primary (organic) MR, due to underlying
degenerative/structural mitral valve (MV) pathology, and secondary (functional) MR,
which is principally caused by global or regional left ventricular remodelling
and/or severe left atrial dilation. Diagnosis and optimal management of MR requires
integration of valve disease and heart failure specialists, MV cardiac surgeons,
interventional cardiologists with expertise in structural heart disease, and
imaging experts. The introduction of transcatheter MV therapies has highlighted
the need for a consensus approach to pragmatic clinical trial design and uniform
endpoint definitions to evaluate outcomes in patients with MR. The Mitral Valve
Academic Research Consortium is a collaboration between leading academic research
organizations and physician-scientists specializing in MV disease from the United
States and Europe. Three in-person meetings were held in Virginia and New York
during which 44 heart failure, valve, and imaging experts, MV surgeons and
interventional cardiologists, clinical trial specialists and statisticians, and
representatives from the U.S. Food and Drug Administration considered all aspects
of MV pathophysiology, prognosis, and therapies, culminating in a 2-part document
describing consensus recommendations for clinical trial design (Part 1) and
endpoint definitions (Part 2) to guide evaluation of transcatheter and surgical
therapies for MR. The adoption of these recommendations will afford robustness and
consistency in the comparative effectiveness evaluation of new devices and
approaches to treat MR. These principles may be useful for regulatory assessment of
new transcatheter MV devices, as well as for monitoring local and regional outcomes
to guide quality improvement initiatives.
AD - Columbia University Medical Center/New York-Presbyterian Hospital, New York,
New York Cardiovascular Research Foundation, New York, New York
gs2184@columbia.edu.
Mount Sinai Health System, New York, New York.
The Ohio State University, Columbus, Ohio.
Erasmus University Medical Center, Rotterdam, the Netherlands.
Columbia University Medical Center/New York-Presbyterian Hospital, New York, New
York Cardiovascular Research Foundation, New York, New York Hôpital du Sacré-Coeur
de Montréal, Montreal, Quebec, Canada.
Hartcentrum Hasselt, Hasselt, Belgium.
Cardiovascular Research Foundation, New York, New York Mount Sinai Health System,
New York, New York.
Asklepios Hospital St. Georg, Hamburg, Germany.
Columbia University Medical Center/New York-Presbyterian Hospital, New York, New
York Cardiovascular Research Foundation, New York, New York.
McGill University Health Center, Montreal, Quebec, Canada.
Athens University Hospital Attikon, Athens, Greece.
the Hôpital Bichat, Paris, France. For complete information on the MVARC members
and participants, please see the Online Appendix. The MVARC initiative was funded
by unrestricted grant support from Abbott Vascular, Boston Scientific, Cardiac
Dimensions, Cordis, Edwards Lifesciences, Guided Delivery Systems Inc., Mitralign,
Medtronic, Valtech. Dr. Stone has served as a consultant for AGA Medical,
AstraZeneca, Atrium, Boston Scientific, Cardiovascular Systems, Inc., Eli
Lilly/Daiichi Sankyo partnership, InfraReDx, InspireMD, Miracor, Osprey, Reva,
TherOx, Thoratec, Velomedix, and Volcano; and has equity in the Biostar and
MedFocus family of funds, Caliber, Guided Delivery Systems, MiCardia, and Vascular
Nanotransfer Technologies. Dr. Adams has received royalties for intellectual
property paid to his medical institution from Edwards Lifesciences and Medtronic.
AN - 26170468
AU - Stone, G. W.
AU - Adams, D. H.
AU - Abraham, W. T.
AU - Kappetein, A. P.
AU - Généreux, P.
AU - Vranckx, P.
AU - Mehran, R.
AU - Kuck, K. H.
AU - Leon, M. B.
AU - Piazza, N.
AU - Head, S. J.
AU - Filippatos, G.
AU - Vahanian, A. S.
DA - Aug 1
DO - 10.1093/eurheartj/ehv333
DP - NLM
ET - 2015/07/15
IS - 29
KW - Acute Kidney Injury/etiology/mortality
Arrhythmias, Cardiac/etiology/mortality
Cardiac Catheterization/adverse effects/*methods/mortality
Clinical Trials as Topic/*methods
Consensus
Endpoint Determination
Hospitalization
Humans
Mitral Valve Insufficiency/mortality/*surgery
Multidetector Computed Tomography/methods
Myocardial Infarction/etiology/mortality
Postoperative Hemorrhage/etiology/mortality
Prosthesis Failure
Risk Assessment
Treatment Outcome
Heart failure
Mitral regurgitation
Mitral valve
Valve intervention
Valve surgery (or cardiac surgery)
LA - eng
N1 - 1522-9645
Stone, Gregg W
Adams, David H
Abraham, William T
Kappetein, Arie Pieter
Généreux, Philippe
Vranckx, Pascal
Mehran, Roxana
Kuck, Karl-Heinz
Leon, Martin B
Piazza, Nicolo
Head, Stuart J
Filippatos, Gerasimos
Vahanian, Alec S
Mitral Valve Academic Research Consortium (MVARC)
Journal Article
Review
England
Eur Heart J. 2015 Aug 1;36(29):1878-91. doi: 10.1093/eurheartj/ehv333. Epub 2015
Jul 13.
PY - 2015
SN - 0195-668x
SP - 1878-91
ST - Clinical trial design principles and endpoint definitions for transcatheter
mitral valve repair and replacement: part 2: endpoint definitions: A consensus
document from the Mitral Valve Academic Research Consortium
T2 - Eur Heart J
TI - Clinical trial design principles and endpoint definitions for transcatheter
mitral valve repair and replacement: part 2: endpoint definitions: A consensus
document from the Mitral Valve Academic Research Consortium
VL - 36
ID - 2674
ER -
TY - JOUR
AB - BACKGROUND: Because no series has specifically analyzed the impact of
preoperative atrial fibrillation (AF) on patients already at higher risk of
thromboembolism after implantation of a left ventricular assist device (LVAD), we
review our experience with these patients. METHODS: Between July 2003 and September
2011, 389 patients (308 male) underwent implantation of a continuous flow LVAD at
University of Michigan Hospital and Mayo Clinic. Median age at implant was 60 years
(range, 18 to 79 years). Preoperative AF was present in 120 patients (31%).
Outcomes were analyzed for the association of preoperative AF and postoperative
thromboembolic (TE) events defined as stroke, transient ischemic attack, hemolysis,
or pump thrombosis. Thromboembolic events occurring within the first 30 days were
not counted. RESULTS: One hundred thirty-eight TEs events occurred in 97/389
patients (25%) for an event rate of 0.31 TE events/patient-years of support.
Freedom from a TE event in patients with preoperative AF was 62% at 1 year and 46%
at 2 years compared with 79% and 72% at 1 and 2 years, respectively, in patients
without preoperative AF (p < 0.001). Median survival was 10 months (maximum 7.2
years, total 439 patient-years). Preoperative AF did not decrease late survival at
1 and 2 years after LVAD implant (preop AF: 85% and 70% versus no preop AF: 82% and
70%, respectively; p = 0.55). CONCLUSIONS: Patients with preoperative AF have a
lower freedom from TE events after LVAD implant. While overall late survival was
not significantly reduced in these patients, refinement in anticoagulation
strategies after VAD implant may be required.
AD - Division of Cardiovascular Surgery, Department of General Surgery, Mayo
Clinic College of Medicine, Rochester, Minnesota. Electronic address:
stulak.john@mayo.edu.
AN - 24035302
AU - Stulak, J. M.
AU - Deo, S.
AU - Schirger, J.
AU - Aaronson, K. D.
AU - Park, S. J.
AU - Joyce, L. D.
AU - Daly, R. C.
AU - Pagani, F. D.
DA - Dec
DO - 10.1016/j.athoracsur.2013.07.004
DP - NLM
ET - 2013/09/17
IS - 6
KW - Adolescent
Adult
Aged
Female
Follow-Up Studies
Heart Failure/complications/*therapy
Humans
Incidence
Male
Michigan/epidemiology
Middle Aged
Preoperative Period
Prognosis
Risk Factors
Young Adult
24
27
Af
Ci
Gi
Hr
Inr
Lvad
Te
Tia
Vad
atrial fibrillation
confidence interval
gastrointestinal
hazard ratio
international normalized ratio
left ventricular assist device
preop
preoperative
thromboembolic
ventricular assist device
LA - eng
N1 - 1552-6259
Stulak, John M
Deo, Salil
Schirger, John
Aaronson, Keith D
Park, Soon J
Joyce, Lyle D
Daly, Richard C
Pagani, Francis D
Comparative Study
Journal Article
Netherlands
Ann Thorac Surg. 2013 Dec;96(6):2161-7. doi: 10.1016/j.athoracsur.2013.07.004. Epub
2013 Sep 12.
PY - 2013
SN - 0003-4975
SP - 2161-7
ST - Preoperative atrial fibrillation increases risk of thromboembolic events
after left ventricular assist device implantation
TI - Preoperative atrial fibrillation increases risk of thromboembolic events
after left ventricular assist device implantation
VL - 96
ID - 2972
ER -
TY - JOUR
AB - OBJECTIVE: Although global left ventricular longitudinal systolic strain
(GLS) is a sensitive measure of left ventricular mechanics, its relationship with
adverse cardiovascular (CV) events in atrial fibrillation (AF) has not been
evaluated. This study sought to examine the ability of GLS in predicting CV events
in AF. DESIGN: Observational cohort study. SETTING: Department of cardiology in a
university hospital. PATIENTS: 196 persistent AF patients referred for
echocardiographic examination. MAIN OUTCOME MEASURES: The risk of GLS measured by
index beat method for CV events was assessed by Cox proportional hazards analyses.
CV events were defined as CV death, non-fatal stroke and hospitalisation for heart
failure. RESULTS: There were 19 CV deaths, 12 non-fatal stroke and 28
hospitalisations for heart failure during an average follow-up of 21 ± 10 months.
Multivariate analysis showed worsening GLS (HR 1.121; 95% CI 1.023 to 1.228,
p=0.014) was independently associated with increased CV events. In direct
comparison, GLS outperformed left ventricular ejection fraction (LVEF) and systolic
mitral annulus velocity (Sa) in predicting adverse CV events both in univariate and
multivariate models (p ≤ 0.043). Besides, the addition of GLS to a Cox model
containing chronic heart failure, hypertension, age ≥ 75 years, diabetes, prior
stroke score, estimated glomerular filtration rate, LVEF and Sa provided an
additional benefit in the prediction of adverse CV events (p=0.022). CONCLUSIONS:
GLS was a major parameter and stronger than LVEF and Sa in predicting adverse CV
events and could offer an additional prognostic benefit over conventional clinical
and echocardiographic systolic parameters in AF.
University Hospital, Kaohsiung Medical University, , Kaohsiung, Taiwan.
AN - 24014280
AU - Su, H. M.
AU - Lin, T. H.
AU - Hsu, P. C.
AU - Lee, W. H.
AU - Chu, C. Y.
AU - Lee, C. S.
AU - Voon, W. C.
AU - Lai, W. T.
AU - Sheu, S. H.
DA - Nov
DO - 10.1136/heartjnl-2013-304561
DP - NLM
ET - 2013/09/10
IS - 21
KW - Aged
Aged, 80 and over
Atrial Fibrillation/*complications/diagnosis/mortality/physiopathology/therapy
Biomechanical Phenomena
Electrocardiography
Female
Heart Failure/*etiology/mortality/physiopathology/therapy
Hospitalization
Humans
Linear Models
Male
Middle Aged
Prognosis
Prospective Studies
Risk Assessment
Risk Factors
Stress, Mechanical
Stroke/*etiology/mortality/physiopathology/therapy
*Systole
LA - eng
N1 - 1468-201x
Su, Ho-Ming
Lin, Tsung-Hsien
Hsu, Po-Chao
Lee, Wen-Hsien
Chu, Chun-Yuan
Lee, Chee-Siong
Voon, Wen-Chol
Lai, Wen-Ter
Sheu, Sheng-Hsiung
Journal Article
Observational Study
England
Heart. 2013 Nov;99(21):1588-96. doi: 10.1136/heartjnl-2013-304561. Epub 2013 Sep 7.
PY - 2013
SN - 1355-6037
SP - 1588-96
ST - Global left ventricular longitudinal systolic strain as a major predictor of
cardiovascular events in patients with atrial fibrillation
T2 - Heart
TI - Global left ventricular longitudinal systolic strain as a major predictor of
cardiovascular events in patients with atrial fibrillation
VL - 99
ID - 2546
ER -
TY - JOUR
AB - The management of a pregnant patient with mitral stenosis is a subject of
debate with regards to the optimal type of treatment and the time of intervention.
We performed trans-ventricular mitral commissurotomy (TVMC) either as an isolated
procedure in the second trimester, or in combination with Cesarian section at term.
We retrospectively analyzed our experience with TVMC during pregnancy and
formulated a protocol for its management. Between January 1987 and April 2002,
fifty one patients underwent TVMC for critical mitral stenosis during pregnancy. In
38 patients, elective TVMC was performed during the second trimester, while in 12,
it was performed as an initial procedure along with Cesarian section at term. One
patient had an emergency TVMC in the second trimester when she presented with
intractable acute pulmonary edema. There were no maternal mortalities. Three
patients who developed post-operative mitral regurgitation were managed
conservatively. Another two patients who developed cerebral embolism with
hemiplegia recovered completely without any neurological deficit. There was only
one fetal death in a patient where TVMC was performed as an emergency procedure for
acute pulmonary edema. We conclude that TVMC in pregnancy is a safe, cost effective
alternative in critical mitral stenosis complicating pregnancy.
AD - Department of Cardiothoracic Surgery, Jawaharlal Institute of Post Graduate
Medical Education and Research, Pondicherry, India. subbarao_ksvk@rediffmail.com
AN - 15353462
AU - Subbarao, K. S.
AU - Nachiappan, M.
AU - Irineu, A. P.
DA - Sep
DO - 10.1177/021849230401200311
DP - NLM
ET - 2004/09/09
IS - 3
J2 - Asian cardiovascular & thoracic annals
KW - Adult
Catheterization/methods
Cesarean Section
Female
Humans
Mitral Valve/pathology/surgery
Mitral Valve Stenosis/complications/*surgery
Postoperative Care
Pregnancy
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Time Factors
Toxoplasmosis, Cerebral/etiology
LA - eng
N1 - Subbarao, Kasturi S V K
Nachiappan, Muthuraman
Irineu, Antao P
Comparative Study
Journal Article
England
Asian Cardiovasc Thorac Ann. 2004 Sep;12(3):233-5. doi: 10.1177/021849230401200311.
PY - 2004
SN - 0218-4923 (Print)
0218-4923
SP - 233-5
ST - Transventricular mitral commissurotomy in critical mitral stenosis during
pregnancy
T2 - Asian Cardiovasc Thorac Ann
TI - Transventricular mitral commissurotomy in critical mitral stenosis during
pregnancy
VL - 12
ID - 3028
ER -
TY - JOUR
AB - BACKGROUND AND OBJECTIVE: Recent randomized studies have shown the potential
of prolonged cardiac rhythm monitoring to detect silent paroxysmal atrial
fibrillation (PAF) in patients with cryptogenic stroke. Our aim was to identify
clinical and magnetic resonance imaging (MRI) factors that predict the detection of
PAF during long-duration rhythm cardiac Holter (LDRCH) monitoring. METHODS: A
retrospective analysis was performed using data from 171 patients with cryptogenic
stroke or transient ischemic attack who underwent LDRCH monitoring (i.e., 21 days)
from 2009 to 2013. Clinical, echocardiographic, and imaging predictors of atrial
fibrillation (AF) were determined by multivariable analysis. RESULTS: PAF lasting
more than or equal to 30 seconds was diagnosed in 26 of 171 (15%) patients. Median
delay to first detected AF episode was 7 (interquartile range: 2-13) days. Four
factors were independently predictive of PAF detection on LDRCH: age more than 70
years (odds ratio [OR], 4.6; 95% confidence interval [CI], 1.5-13.8); premature
atrial complex on electrocardiogram (OR, 4.6; 95% CI, 1.1-19.6); left ventricular
hypertrophy on transthoracic echocardiography (OR, 6.4, 95% CI, 1.6-26.4); and
previous white matter lesions on brain MRI (OR, 4.2; 95% CI, 1.2-15.6). Recent
brain infarction pattern on diffusion-weighted imaging was not associated with PAF
detection on LDRCH. CONCLUSION: LDRCH is a noninvasive and inexpensive test with a
high rate of AF detection in patients with cryptogenic stroke or transient ischemic
attack. Occult PAF was more commonly diagnosed in older patients with premature
atrial complex on the baseline electrocardiogram, left ventricular hypertrophy on
echocardiography, and with previous white matter lesions on brain MRI.
AD - Neurology Department and Stroke Center, Mignot Hospital, Le Chesnay, France.
Cardiology Department, Parly 2 Clinic, Le Chesnay, France.
DRCI (Delegation à la Recherche Clinique), Mignot Hospital, Le Chesnay, France.
Neurology Department and Stroke Center, Mignot Hospital, Le Chesnay, France;
Versailles Saint-Quentin en Yvelines University, Versailles, France; INSERM LVTS
(Laboratory for Vascular Translational Science)-1148, Paris, France. Electronic
address: fpico@ch-versailles.fr.
AN - 27495831
AU - Sudacevschi, V.
AU - Bertrand, C.
AU - Chadenat, M. L.
AU - Tarnaud, C.
AU - Pico, F.
DA - Nov
DP - NLM
ET - 2016/08/09
IS - 11
KW - Age Factors
Aged
Aged, 80 and over
Atrial Fibrillation/*diagnosis/etiology/physiopathology
Atrial Premature Complexes/complications/diagnosis/physiopathology
Echocardiography
*Electrocardiography, Ambulatory
Female
Humans
Hypertrophy, Left Ventricular/complications/diagnostic imaging
Leukoencephalopathies/complications/diagnostic imaging
Logistic Models
Male
Middle Aged
Odds Ratio
Risk Factors
*mri
*Stroke
*long-duration rhythm cardiac Holter
*vascular risk factors
LA - eng
N1 - 1532-8511
Sudacevschi, Veronica
Bertrand, Cathy
Chadenat, Marie L
Tarnaud, Chloé
Pico, Fernando
Journal Article
United States
J Stroke Cerebrovasc Dis. 2016 Nov;25(11):2673-2677. doi:
10.1016/j.jstrokecerebrovasdis.2016.07.014. Epub 2016 Aug 2.
PY - 2016
SN - 1052-3057
SP - 2673-2677
ST - Predictors of Occult Atrial Fibrillation in One Hundred Seventy-One Patients
with Cryptogenic Transient Ischemic Attack and Minor Stroke
TI - Predictors of Occult Atrial Fibrillation in One Hundred Seventy-One Patients
with Cryptogenic Transient Ischemic Attack and Minor Stroke
VL - 25
ID - 2355
ER -
TY - JOUR
AB - BACKGROUND: Tracking down atrial fibrillation (AF) in the stroke unit is a
relevant challenge for the prevention of recurrent AF-related stroke. The optimal
terms of use of continuous ECG monitoring (CEM) are unknown. We compared 24-hour
routine Holter ECG with two different CEM analysis strategies for AF detection.
METHODS: We prospectively enrolled consecutive ischemic stroke patients. All AF-
naïve patients received CEM during hospitalization. Two methods for reading CEM
data were compared: manual analysis using the Holter function (hCEM) and
semiautomated analysis using software (aCEM). The McNemar test was used to compare
AF detection rates. RESULTS: Of the 362 patients included, 58 (16.0%) were non-AF-
naïve patients and 304 were AF-naïve patients. AF-Naïve patients underwent CEM with
a median duration of 5.3 days (3.4-9.7). We detected 22 new AF cases (7.2%) with
first-24-hour hCEM, 31 (10.2%) with aCEM, and 42 (13.8%) with hCEM. hCEM and aCEM
both significantly increased the AF detection rate compared to first-24-hour hCEM.
hCEM detected more new AF cases than aCEM (+3.6%, p = 0.003). CONCLUSIONS: In
stroke patients, early and prolonged aCEM and hCEM both increase the AF detection
rate compared to first-24-hour hCEM. hCEM gives the best AF detection rate. We
suggest that in aCEM, detection based only on the ventricular rhythm analysis
explains its lower specificity and sensitivity.
AD - Stroke Center, University Hospital of Nice, Nice, France.
AN - 24777038
AU - Suissa, L.
AU - Lachaud, S.
AU - Mahagne, M. H.
DO - 10.1159/000358053
DP - NLM
ET - 2014/04/30
IS - 1-2
KW - Acute Disease
Aged
Atrial Fibrillation/complications/*diagnosis/physiopathology
Brain Ischemia/*complications/physiopathology
Diagnosis, Computer-Assisted/*methods
Female
Hospitalization
Humans
Male
Middle Aged
Pattern Recognition, Automated/*methods
Prospective Studies
ROC Curve
Software
Time Factors
LA - eng
N1 - 1421-9913
Suissa, Laurent
Lachaud, Sylvain
Mahagne, Marie-Hélène
Comparative Study
Journal Article
Observational Study
Switzerland
Eur Neurol. 2014;72(1-2):7-12. doi: 10.1159/000358053. Epub 2014 Apr 25.
PY - 2014
SN - 0014-3022
SP - 7-12
ST - Continuous ECG monitoring for tracking down atrial fibrillation after stroke:
Holter or automated analysis strategy?
T2 - Eur Neurol
TI - Continuous ECG monitoring for tracking down atrial fibrillation after stroke:
Holter or automated analysis strategy?
VL - 72
ID - 2542
ER -
TY - JOUR
AB - Left ventricular (LV) scar identified by late gadolinium enhanced (LGE)
cardiac magnetic resonance (CMR) is associated with adverse outcomes in coronary
artery disease and cardiomyopathies. We sought to determine the prognostic
significance of LV-LGE in atrial fibrillation (AF). We studied 778 consecutive
patients referred for radiofrequency ablation of AF who underwent CMR. Patients
with coronary artery disease, previous myocardial infarction, or hypertrophic or
dilated cardiomyopathy were excluded. The end points of interest were major adverse
cardiac and cerebrovascular events (MACCE), defined as a composite of
cardiovascular death, myocardial infarction, and ischemic stroke/transient ischemic
attack. Of the 754 patients who met the inclusion criteria, 60% were men with an
average age of 64 years. Most (87%) had a normal LV ejection fraction of ≥55%. LV-
LGE was found in 46 patients (6%). There were 32 MACCE over the mean follow-up
period of 55 months. The MACCE rate was higher for patients with LV-LGE (13.0% vs
3.7%; p = 0.002). In multivariate analysis, CHA2DS2-VASc score (hazard ratio [HR]
1.36, 95% CI 1.05 to 1.76), the presence of LV-LGE (HR 3.21, 95% CI 1.31 to 7.88),
and the LV-LGE extent (HR 1.43, 95% CI 1.15 to 1.78) were independent predictors of
MACCE. In addition, the presence of LV-LGE was an independent predictor for
ischemic stroke/transient ischemic attack (HR 3.61, 95% CI 1.18 to 11.01) after
adjusting for CHA2DS2-VASc score. In conclusion, the presence and extent of LV scar
identified by LGE-CMR were independent predictors of MACCE in patients with AF.
AD - Division of Cardiovascular Medicine, University of Utah, Salt Lake City,
Utah; Comprehensive Arrhythmia Research & Management Center, Salt Lake City, Utah.
Comprehensive Arrhythmia Research & Management Center, Salt Lake City, Utah;
Division of Cardiology, University of Washington, Seattle, Washington.
Department of Pharmacotherapy, University of Utah, Salt Lake City, Utah.
Department of Epidemiology, University of Utah, Salt Lake City, Utah.
Comprehensive Arrhythmia Research & Management Center, Salt Lake City, Utah; Utah
Center for Advanced Imaging Research, University of Utah, Salt Lake City, Utah.
Division of Cardiovascular Medicine, University of Utah, Salt Lake City, Utah.
Division of Cardiovascular Medicine, University of Utah, Salt Lake City, Utah;
Comprehensive Arrhythmia Research & Management Center, Salt Lake City, Utah.
Electronic address: brent.wilson@hsc.utah.edu.
AN - 27553101
AU - Suksaranjit, P.
AU - McGann, C. J.
AU - Akoum, N.
AU - Biskupiak, J.
AU - Stoddard, G. J.
AU - Kholmovski, E. G.
AU - Navaravong, L.
AU - Rassa, A.
AU - Bieging, E.
AU - Chang, L.
AU - Haider, I.
AU - Marrouche, N. F.
AU - Wilson, B. D.
DA - Oct 1
DO - 10.1016/j.amjcard.2016.06.054
DP - NLM
ET - 2016/08/25
IS - 7
KW - Aged
Atrial Fibrillation/*diagnostic imaging/epidemiology/surgery
Catheter Ablation
Cicatrix/*diagnostic imaging/epidemiology
Contrast Media
Dyslipidemias/epidemiology
Female
Follow-Up Studies
Gadolinium
Heart Ventricles/*diagnostic imaging
Humans
Logistic Models
Magnetic Resonance Imaging, Cine
Male
Middle Aged
Odds Ratio
Prognosis
Risk Factors
Stroke/epidemiology
Time Factors
LA - eng
N1 - 1879-1913
Suksaranjit, Promporn
McGann, Christopher J
Akoum, Nazem
Biskupiak, Joseph
Stoddard, Gregory J
Kholmovski, Eugene G
Navaravong, Leenhapong
Rassa, Allen
Bieging, Erik
Chang, Lowell
Haider, Imran
Marrouche, Nassir F
Wilson, Brent D
Journal Article
United States
Am J Cardiol. 2016 Oct 1;118(7):991-7. doi: 10.1016/j.amjcard.2016.06.054. Epub
2016 Jul 18.
PY - 2016
SN - 0002-9149
SP - 991-7
ST - Prognostic Implications of Left Ventricular Scar Determined by Late
Gadolinium Enhanced Cardiac Magnetic Resonance in Patients With Atrial Fibrillation
T2 - Am J Cardiol
TI - Prognostic Implications of Left Ventricular Scar Determined by Late
Gadolinium Enhanced Cardiac Magnetic Resonance in Patients With Atrial Fibrillation
VL - 118
ID - 2330
ER -
TY - JOUR
AB - We have long known that patients with vascular disease in one system are at
risk for vascular disease in other systems. Beyond this, we are recognizing the
increased risk for cardiovascular patients to develop stroke not only as the result
of arrhythmia, but also at the time of cardiovascular events or procedures. This
presents clinical challenges to nurses with either neurological or cardiovascular
expertise, requiring development of new awareness, clinical and critical thinking
skills, and collaboration with their colleagues in other specialties. Three case
studies illustrate patient presentations ranging from the subtle to the obvious.
Pathophysiology of stroke is reviewed. Leading-edge management strategies and
supporting literature highlight the benefits of prompt identification and
management of the stroke patient. The Stroke Watch Action Team (SWAT) has proved to
be an effective means of expediting patient identification and access to effective
stroke treatment.
AD - Saint Luke's Hospital, USA.
AN - 10826297
AU - Summers, D.
AU - Pyle, J.
AU - Stahl, M.
AU - Hileman, J.
DA - Apr
DO - 10.1097/01376517-200004000-00007
DP - NLM
ET - 2000/05/29
IS - 2
J2 - The Journal of neuroscience nursing : journal of the American Association of
Neuroscience Nurses
KW - Adolescent
Aged
Atrial Fibrillation/nursing
Heart Diseases/*nursing
Humans
Male
*Nursing Assessment
Risk Factors
Stroke/*nursing
Thrombolytic Therapy/nursing
Ventricular Premature Complexes/nursing
LA - eng
N1 - Summers, D
Pyle, J
Stahl, M
Hileman, J
Case Reports
Journal Article
United States
J Neurosci Nurs. 2000 Apr;32(2):108-16. doi: 10.1097/01376517-200004000-00007.
PY - 2000
SN - 0888-0395 (Print)
0888-0395
SP - 108-16
ST - The heart-brain connection
T2 - J Neurosci Nurs
TI - The heart-brain connection
VL - 32
ID - 2571
ER -
TY - JOUR
AB - OBJECTIVE: The prognostic significance of left and right bundle branch block
(LBBB and RRBB) in patients with chronic stable cardiovascular (CV) disease is not
well characterized and was evaluated in the Heart Outcomes Prevention Evaluation
(HOPE) study cohort. DESIGN: Observational analysis of data prospectively collected
in the HOPE trial. SETTING AND PATIENTS: HOPE was a multicenter, international
trial, which evaluated ramipril and vitamin E in 9,541 patients aged > or = 55
years with CV disease or diabetes with > or = 1 CV risk factor(s) but without heart
failure (HF) or known left ventricular systolic dysfunction. Follow-up extended for
a median of 4.5 years. Electrocardiograms were obtained at baseline in all study
participants and were read centrally. MAIN OUTCOME MEASURES: Major CV events
(defined as CV death, myocardial infarction, or stroke), heart failure, CV death,
all-cause death, and sudden death. RESULTS: Baseline LBBB was present in 246 (2.6%)
patients and was associated with increased risk for major CV events (HR = 1.54; 95%
CI, 1.18-2.02), CV death (HR 2.29; 95% CI, 1.63-3.20), heart failure (HR 2.99; 95%
CI, 2.31-3.87), sudden death (HR 3.17; 95% CI, 2.13-4.73), and all-cause death (HR
= 2.10; 95% CI, 1.59-2.77). In multivariate models, LBBB remained an independent
predictor of heart failure, sudden death, CV death, and all-cause death (P < or =
0.002 for all). Baseline RBBB was present in 428 (4.5%) of patients and was not
associated with increased CV risk. CONCLUSIONS: In patients with stable chronic CV
disease, LBBB but not RBBB is an independent predictor of heart failure, sudden
death, CV death, and all-cause death.
AD - Department of Medicine, Division of Cardiology, McMaster University,
Hamilton, Ontario, Canada.
AN - 19298567
AU - Sumner, G.
AU - Salehian, O.
AU - Yi, Q.
AU - Healey, J.
AU - Mathew, J.
AU - Al-Merri, K.
AU - Al-Nemer, K.
AU - Mann, J. F.
AU - Dagenais, G.
AU - Lonn, E.
DA - Jul
DO - 10.1111/j.1540-8167.2009.01440.x
DP - NLM
ET - 2009/03/21
IS - 7
KW - Aged
Bundle-Branch Block/*complications/mortality/physiopathology
Cardiovascular Diseases/*etiology/mortality/physiopathology
Chronic Disease
Death, Sudden/etiology
Double-Blind Method
Electrocardiography
Europe
Female
Humans
Male
Middle Aged
Myocardial Infarction/etiology/mortality
North America
Prospective Studies
Ramipril/*therapeutic use
Risk Assessment
Risk Factors
Time Factors
Treatment Outcome
Vascular Diseases/complications/*drug therapy/mortality/physiopathology
Vitamin E/*therapeutic use
LA - eng
N1 - 1540-8167
Sumner, Glen
Salehian, Omid
Yi, Qilong
Healey, Jeff
Mathew, James
Al-Merri, Khalid
Al-Nemer, Khaled
Mann, J F E
Dagenais, Gilles
Lonn, Eva
HOPE Investigators
Journal Article
Multicenter Study
United States
J Cardiovasc Electrophysiol. 2009 Jul;20(7):781-7. doi: 10.1111/j.1540-
8167.2009.01440.x. Epub 2009 Feb 27.
PY - 2009
SN - 1045-3873
SP - 781-7
ST - The prognostic significance of bundle branch block in high-risk chronic
stable vascular disease patients: a report from the HOPE trial
TI - The prognostic significance of bundle branch block in high-risk chronic
stable vascular disease patients: a report from the HOPE trial
VL - 20
ID - 2650
ER -
TY - JOUR
AB - Eighty-three patients with acute ischemic stroke (56 men and 27 women, mean
age 90.1 +/- 10.8 years) were examined in order to elucidate the significance of
paroxysmal heart rhythm disorders and silent myocardial ischemia and determine the
pattern of hemorheological changes. Traditional clinical instrumental examinations
were supplemented by Holter monitoring and measurements of a wide spectrum of
hemostatic and hemorheological values. Cardiogenic ischemic strokes were
pathogenetically heterogeneous. Holter monitoring helped detect the significance of
paroxysmal atrial fibrillation in the pathogenesis of embolic cardiogenic stroke.
One of the key factors in development of hemodynamic cardiogenic stroke was
transitory bradyarrhythmia and deterioration of left-ventricular contractility.
Cardiogenic strokes are associated with hemostatic activation with predominant
changes in the plasma hemostasis, which dictates purposeful hemocorrection.
AN - 11510177
AU - Suslina, Z. A.
AU - Tanashian, M. M.
AU - Petrova, E. A.
AU - Ionova, V. G.
AU - Foniakin, A. V.
DP - NLM
ET - 2001/08/21
IS - 5
KW - Adult
Aged
Brain/blood supply
Brain Ischemia/complications/pathology
Female
Humans
Male
Middle Aged
LA - rus
N1 - Suslina, Z A
Tanashian, M M
Petrova, E A
Ionova, V G
Foniakin, A V
English Abstract
Journal Article
Russia (Federation)
Klin Med (Mosk). 2001;79(5):15-9.
OP - Patogeneticheskie aspekty kardiogennykh ishemicheskikh insul'tov.
PY - 2001
SN - 0023-2149 (Print)
0023-2149
SP - 15-9
ST - [Cardiogenic ischemic strokes: pathogenetic aspects]
TI - [Cardiogenic ischemic strokes: pathogenetic aspects]
VL - 79
ID - 2705
ER -
TY - JOUR
AB - PURPOSE: To determine whether regional cerebral functional abnormalities
exist in patients with apraxia of lid opening (ALO). METHODS: Cerebral glucose
metabolism was examined by positron emission tomography (PET) in 11 patients (8
women and 3 men, age 48-69 years); 10 with ALO accompanied by blepharospasm and 1
patient with pure ALO. Eleven normal volunteers (6 women and 5 men, age 45-66
years) were examined as controls. A comprehensive ophthalmological examination,
magnetic resonance imaging (MRI), and PET were performed. The cerebral glucose
metabolism was evaluated by the relative uptake of [fluorine-18]fluorodeoxyglucose
by PET. The mean +/- two standard deviations of the normal controls was defined as
the normal range for cerebral glucose metabolism. RESULTS: MRI revealed no
particular lesion except for an infarction in the unilateral basal ganglia in two
patients. Decreased glucose metabolism was observed in a wide area of the medial
frontal lobe (six cases) and primary visual cortex (PVC) (four cases). Group
multiple comparisons revealed a significant decrease ( P<0.0035) in the bilateral
anterior cingulate gyrus, left supplementary motor area (SMA), and bilateral PVC.
CONCLUSION: The results support the hypothesis that ALO is associated with
hypofunction in the SMA and/or anterior cingulate gyrus.
AD - Department of Ophthalmology and Visual Science, School of Medicine, Tokyo
Medical and Dental University, Yushima 1-chome 5-45, Bunkyo-ku, 113-8519 , Tokyo,
Japan.
Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Department of Ophthalmology and Visual Science, School of Medicine, Tokyo Medical
and Dental University, Yushima 1-chome 5-45, Bunkyo-ku, 113-8519 , Tokyo, Japan.
m.kiyosawa.oph@tmd.ac.jp.
Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
m.kiyosawa.oph@tmd.ac.jp.
Laboratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Department of Neurology, Tokyo Medical and Dental University, Tokyo, Japan.
AN - 12819975
AU - Suzuki, Y.
AU - Kiyosawa, M.
AU - Ohno, N.
AU - Mochizuki, M.
AU - Inaba, A.
AU - Mizusawa, H.
AU - Ishii, K.
AU - Senda, M.
DA - Jul
DO - 10.1007/s00417-003-0682-0
DP - NLM
ET - 2003/06/24
IS - 7
J2 - Graefe's archive for clinical and experimental ophthalmology = Albrecht von
Graefes Archiv fur klinische und experimentelle Ophthalmologie
KW - Aged
Apraxia, Ideomotor/diagnosis/*metabolism/physiopathology
Electromyography
Eyelid Diseases/diagnosis/*metabolism/physiopathology
Female
Frontal Lobe/diagnostic imaging/*metabolism/pathology
Glucose/*deficiency
Gyrus Cinguli/metabolism
Humans
Male
Middle Aged
Motor Cortex/diagnostic imaging/metabolism/pathology
Tomography, Emission-Computed
Visual Cortex/diagnostic imaging/metabolism/pathology
LA - eng
N1 - Suzuki, Yukihisa
Kiyosawa, Motohiro
Ohno, Naonori
Mochizuki, Manabu
Inaba, Akira
Mizusawa, Hidehiro
Ishii, Kenji
Senda, Michio
Journal Article
Germany
Graefes Arch Clin Exp Ophthalmol. 2003 Jul;241(7):529-534. doi: 10.1007/s00417-003-
0682-0. Epub 2003 Jun 18.
PY - 2003
SN - 0721-832X (Print)
0721-832x
SP - 529-534
ST - Glucose hypometabolism in medial frontal cortex of patients with apraxia of
lid opening
T2 - Graefes Arch Clin Exp Ophthalmol
TI - Glucose hypometabolism in medial frontal cortex of patients with apraxia of
lid opening
VL - 241
ID - 3064
ER -
TY - JOUR
AB - Atrial fibrillation and heart failure have been called the twin
cardiovascular epidemics of the 21st Century. The prevalence of both conditions is
increasing in the elderly and often the two conditions coexist in the same
patients, leading to worse outcomes. Current data show that rate control and rhythm
control are both reasonable strategies for the treatment of atrial fibrillation in
heart failure patients. Emerging data suggest the beneficial effects of novel
therapeutic approaches such as cardiac resynchronization therapy, and pulmonary
vein isolation on left ventricular remodeling and functional outcomes.
Anticoagulation remains a mainstay of therapy for stroke prevention in this high-
risk population.
AD - Northwestern University Feinberg School of Medicine, 676 N. St Clair Street,
Suite 600, Chicago, IL 60611, USA.
AN - 21809972
AU - Svetlichnaya, J.
AU - Klein, L.
DA - Jul
DO - 10.1586/erc.11.89
DP - NLM
ET - 2011/08/04
IS - 7
KW - Aged
Animals
Atrial Fibrillation/complications/epidemiology/*therapy
Cardiac Resynchronization Therapy/methods
Heart Failure/complications/epidemiology/*therapy
Humans
LA - eng
N1 - 1744-8344
Svetlichnaya, Jana
Klein, Liviu
Journal Article
Review
England
Expert Rev Cardiovasc Ther. 2011 Jul;9(7):903-12. doi: 10.1586/erc.11.89.
PY - 2011
SN - 1477-9072
SP - 903-12
ST - Atrial fibrillation in elderly patients with heart failure: convergence of
two cardiovascular epidemics in the 21st Century
TI - Atrial fibrillation in elderly patients with heart failure: convergence of
two cardiovascular epidemics in the 21st Century
VL - 9
ID - 2719
ER -
TY - JOUR
AB - A young woman who sustained severe head trauma presented to the operating
room for emergent surgical intervention. Her electrocardiogram (ECG) exhibited
signs of myocardial ischemia, which resolved several days postoperatively. ECG
changes suggestive of cardiac pathology can be associated with intracranial
pathology, most notably subarachnoid hemorrhage. Delay of operative therapy may
have catastrophic results. Experimental data indicates massive sympathetic outflow
results from stimulation of the lateral and posterior hypothalamic regions. Large
amounts of norepinephrine are released into the systemic circulation, resulting in
hypertension, tachycardia, dysrhythmias and ECG changes. Myocardial ischemia and
injury can occur from the effects of this excessive sympathetic stimulation. In
certain case reports, neurologic patients who experienced ECG changes had normal
hearts on postmortem examination. This implies that myocardial recovery can occur
despite the appearance of an abnormal ECG in the neurologic patient. Anesthetic
management of these patients involves prevention of further increases in
intracranial pressure and avoidance of hyperventilation in the presence of
hypotension or vasospasm. Continuous ECG monitoring is essential. Ventricular
dysrhythmias may prove resistant to conventional pharmaceutical management. Beta
blockade may be indicated to prevent excessive cardiac stimulation by endogenous
catecholamines, and, in addition, may prevent the formation of the microscopic
cardiac lesions typical of this hyperstimulation.
AN - 1950401
AU - Syverud, G.
DA - Jun
DP - NLM
ET - 1991/06/01
IS - 3
J2 - AANA journal
KW - Adult
Anesthesia/methods
Arrhythmias, Cardiac/*diagnosis/drug therapy/etiology
Female
Hematoma, Subdural/*complications/physiopathology/surgery
Humans
LA - eng
N1 - Syverud, G
Case Reports
Journal Article
United States
AANA J. 1991 Jun;59(3):229-32.
PY - 1991
SN - 0094-6354 (Print)
0094-6354
SP - 229-32
ST - Electrocardiographic changes and intracranial pathology
T2 - Aana j
TI - Electrocardiographic changes and intracranial pathology
VL - 59
ID - 2843
ER -
TY - JOUR
AB - Currently, peripheral arterial disease is an underdiagnosed disorder. Several
modifiable and non-modifiable risk factors have role in its development and
progression. As system disorder it might be a part and an important predictor of
fatal cardio- and cerebrovascular events. CASE REPORT: The authors describe the
case of a 73-year-old male with multilocational vascular disorder, with
simultaneously occurring carotid disease, critical limb ischaemia with aorto-
bifemoral bypass, multiple infarction with mechanical complication, inoperable
coronary disease and with implantable cardioverter defibrillator for ventricular
arrhythmia. CONCLUSION: Peripheral arterial disease affects the whole vascular
system and can progress into serious cardiac and cerebral manifestations causing
the patient's death inspite of comprehensive treatment.
AD - Debreceni Egyetem, Orvos- és Egészségtudományi Centrum, Belgyógyászati
Intézet, Belgyógyászati Klinika, Debrecen Móricz Zsigmond út 22. 4004.
bodza78@freemail.hu
AN - 18977741
AU - Szomják, E.
AU - Dér, H.
AU - Kerekes, G.
AU - Veres, K.
AU - Tóth, J.
AU - Olvasztó, S.
AU - Herczku, C.
AU - Soltész, P.
DA - Nov 9
DO - 10.1556/oh.2008.28361
DP - NLM
ET - 2008/11/04
IS - 45
J2 - Orvosi hetilap
KW - Aged
Angiography, Digital Subtraction
Aorta/surgery
Carotid Stenosis/complications
Electrocardiography
Fatal Outcome
Femoral Artery/surgery
Humans
Ischemia/complications/surgery
Leg/blood supply
Male
Peripheral Vascular Diseases/complications/*diagnosis/*therapy
Shock, Cardiogenic/complications
Tachycardia, Ventricular/complications/therapy
Vascular Surgical Procedures
LA - hun
N1 - Szomják, Edit
Dér, Henrietta
Kerekes, György
Veres, Katalin
Tóth, Judit
Olvasztó, Sándor
Herczku, Csaba
Soltész, Pál
Case Reports
English Abstract
Journal Article
Hungary
Orv Hetil. 2008 Nov 9;149(45):2135-40. doi: 10.1556/OH.2008.28361.
OP - Multiplex obliteratív érbetegség. Kihívás a diagnosztikában és a kezelésben.
PY - 2008
SN - 0030-6002 (Print)
0030-6002
SP - 2135-40
ST - [Multiple obliterative vascular disease. Challenge in diagnosis and in
treatment]
T2 - Orv Hetil
TI - [Multiple obliterative vascular disease. Challenge in diagnosis and in
treatment]
VL - 149
ID - 2887
ER -
TY - JOUR
AB - BACKGROUND: Atrial fibrillation (AF) is the most common supraventricular
tachyarrhythmia. Percutaneous left atrial appendage occlusion (LAAO) may be
considered for stroke prophylaxis in patients with nonvalvular AF (NVAF),
especially in contraindications for oral anticoagulants (OAC) or high risk of
bleeding. The data about implantation, safety, efficacy, and follow-up are limited.
Moreover, there are no studies on patients with NVAF and heart failure with severe
left ventricular systolic dysfunction (left ventricular ejection fraction [LVEF] ≤
35%). AIM: To assess the safety, efficacy, and mid-term outcomes of LAAO procedures
with Amplatzer Cardiac Plug (ACP) and Amplatzer Amulet device in patients with NVAF
and heart failure with LVEF ≤ 35% (group I) and to perform a comparative analysis
of the patients who had LAAO with NVAF and LVEF > 35%. METHODS: The analysis
included 80 patients (group I: 19, group II: 61) with NVAF. The patients were
enrolled for the study if they had: CHA2DS2VASc ≥ 2 and high risk of bleeding
assessed in HAS-BLED (≥ 3) or less points in HAS-BLED but coexisting
contraindications for OAC, or thromboembolic complications while using OAC. Time of
follow-up was six months. RESULTS: In the studied population, the median
CHA2DS2VASc score was 4 and the average HAS-BLED score was 3.2. Device implantation
was successful in all patients from group I and in 59/61 patients from group II.
The periprocedural clinical ef-ficacy (no thromboembolic complications) was 100% in
group I and 98.4% in group II. Serious periprocedural complications (cardiac
tamponade: 2.5%, device embolisation: 1.25%, unexplained death: 1.25%) occurred
only in patients from group II (p = NS). The mid-term clinical efficacy was 100% in
group I and 98.3% in group II (p = NS). During follow-up, one transient ischaemic
attack and three deaths not related to the procedure occurred. CONCLUSIONS:
Percutaneous LAAO is an effective and safe procedure in patients with NVAF and
severe systolic heart failure. No significant periprocedural and mid-term
differences, in terms of safety and efficacy, between the group with severe
systolic heart failure (LVEF ≤ 35%) and the group without severe left ventricular
systolic dysfunction (LVEF > 35%) were found.
AD - 1st Department of Cardiology, Congenital Heart Diseases, and Electrotherapy,
Clinical Unit of Cardiology, Silesian Centre for Heart Diseases, Medical University
of Silesia, Zabrze, Poland, Poland. kapmag@poczta.onet.pl.
AN - 28612910
AU - Szymała, M.
AU - Streb, W.
AU - Mitręga, K.
AU - Podolecki, T.
AU - Mencel, G.
AU - Kukulski, T.
AU - Kalarus, Z.
DO - 10.5603/KP.a2017.0115
DP - NLM
ET - 2017/06/15
IS - 9
KW - Aged
Aged, 80 and over
Atrial Appendage
Female
Humans
Male
Middle Aged
Patient Safety
*Therapeutic Occlusion
Treatment Outcome
atrial fibrillation
heart failure
left atrial appendage occlusion
stroke
LA - eng
N1 - 1897-4279
Szymała, Magdalena
Streb, Witold
Mitręga, Katarzyna
Podolecki, Tomasz
Mencel, Grzegorz
Kukulski, Tomasz
Kalarus, Zbigniew
Journal Article
Poland
Kardiol Pol. 2017;75(9):868-876. doi: 10.5603/KP.a2017.0115. Epub 2017 Jun 14.
PY - 2017
SN - 0022-9032
SP - 868-876
ST - Percutaneous left atrial appendage occlusion procedures in patients with
heart failure
T2 - Kardiol Pol
TI - Percutaneous left atrial appendage occlusion procedures in patients with
heart failure
VL - 75
ID - 2566
ER -
TY - JOUR
AB - OBJECTIVE: Patients with cardioembolic stroke (CE) caused by paroxysmal
atrial fibrillation (Paf) sometimes show normal sinus rhythm on admission, which
makes it difficult to diagnose them as having CE. The present study examined the
differences in echocardiographic findings between patients with CE caused by Paf
(the Paf-CE group) and those with non-cardiogenic embolic ischemic stroke (the Non-
CE group). METHODS: We examined thirty-two patients with embolic ischemic stroke
presenting with a normal sinus rhythm upon admission to our hospital; 13 patients
in the Paf-CE group and 19 patients in the Non-CE group. During admission, all
patients underwent transthoracic echocardiography (TTE) and transesophageal
echocardiography (TEE) at a normal sinus rhythm. The left atrial dimension, left
ventricular end-diastolic dimension and left ventricular ejection fraction were
measured using TTE. The left atrial appendage peak flow velocity (LAAPV),
spontaneous echo-contrast in the left atrium (LASEC) and thrombus in the left
atrium were evaluated using TEE. RESULTS: Among the clinical background
characteristics, hypertension was significantly more frequent in the Non-CE group
than in the Paf-CE group (p<0.01). Congestive heart failure was significantly more
frequent in the Paf-CE group than in the Non-CE group (p<0.05). LAAPV was
significantly lower in the Paf-CE group than in the Non-CE group (34.7 cm/s vs.
64.0 cm/s, p<0.01), and the LASEC grade was significantly higher in the Paf-CE
group than in the Non-CE group (p<0.01). A thrombus in the left atrium was detected
in two patients in the Paf-CE group, but no thrombi were detected in any of the
patients in the Non-CE group. CONCLUSION: Echocardiographic evaluation is useful,
as the above data indicate that the left atrial function is apparently impaired in
patients with CE caused by Paf, even in a patient with an apparently normal sinus
rhythm.
AD - Department of Neurology at Toyama University Hospital, Toyama, Japan.
ytagu@med.u-toyama.ac.jp
AN - 20720349
AU - Taguchi, Y.
AU - Takashima, S.
AU - Hirai, T.
AU - Fukuda, N.
AU - Ohara, K.
AU - Nakagawa, K.
AU - Inoue, H.
AU - Tanaka, K.
DP - NLM
ET - 2010/08/20
IS - 16
KW - Aged
Aged, 80 and over
Atrial Fibrillation/*complications/*diagnostic imaging/physiopathology
Female
Humans
Male
Middle Aged
Stroke/*diagnostic imaging/etiology/physiopathology
Thromboembolism/*diagnostic imaging/etiology/physiopathology
LA - eng
N1 - 1349-7235
Taguchi, Yoshiharu
Takashima, Shutaro
Hirai, Tadakazu
Fukuda, Nobuyuki
Ohara, Kazumasa
Nakagawa, Keiko
Inoue, Hiroshi
Tanaka, Kortaro
Comparative Study
Journal Article
Japan
Aug 13.
PY - 2010
SN - 0918-2918
SP - 1727-32
ST - Significant impairment of left atrial function in patients with cardioembolic
stroke caused by paroxysmal atrial fibrillation
T2 - Intern Med
TI - Significant impairment of left atrial function in patients with cardioembolic
stroke caused by paroxysmal atrial fibrillation
VL - 49
ID - 2677
ER -
TY - JOUR
AB - INTRODUCTION: Coronary vasospasm is a transient sudden vasoconstriction of
one of the coronary arteries that can lead to myocardial ischaemia, myocardial
infarction, fatal arrhythmia and sudden death. Most patients with coronary spasm
have underlying cardiac pathology. CASE PRESENTATION: This paper presents a rare
case of intractable autonomic dysreflexia in a 36-year-old patient with chronic C5
paraplegia with silent myocardial ischaemia secondary to coronary vasospasm in the
absence of underlying cardiac pathology. The MRI perfusion study revealed normal
left ventricular contractility and no evidence of coronary artery occlusion.
DISCUSSION: This case highlights the cardiac complications associated with
paroxysmal heightened sympathetic nervous system and proposes that autonomic
dsyreflexia can predisposes to coronary vasospasm via uncontrolled sympathetic
nervous system. The disruption of sensory input from the myocardium to the brain in
patient with SCI predisposes them to asymptomatic myocardial ischaemia. The
challenges in the diagnosis and management of coronary vasospasm associated with
autonomic dysreflexia are described.
AD - Department of Rehabilitative Medicine, University Malaya Medical Centre ,
Kuala Lumpur, Malaysia.
Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya ,
Kuala Lumpur, Malaysia.
AN - 28053771
AU - Tan, S. W.
AU - Rahman, Z. B.
AU - Fauzi, A. A.
AU - Latif, L. A.
AU - Hasnan, N.
C2 - PMC5177686
DO - 10.1038/scsandc.2016.30
DP - NLM
ET - 2017/01/06
J2 - Spinal cord series and cases
KW - Acute coronary syndromes
Diseases
LA - eng
N1 - 2058-6124
Tan, See Wei
Rahman, Zafefe Ba
Fauzi, Aishah A
Latif, Lydia A
Hasnan, Nazirah
Journal Article
Spinal Cord Ser Cases. 2016 Dec 22;2:16030. doi: 10.1038/scsandc.2016.30.
eCollection 2016.
PY - 2016
SN - 2058-6124 (Print)
2058-6124
SP - 16030
ST - Coronary vasospasm in intractable autonomic dysreflexia
T2 - Spinal Cord Ser Cases
TI - Coronary vasospasm in intractable autonomic dysreflexia
VL - 2
ID - 3085
ER -
TY - JOUR
AB - OBJECTIVE: This study aimed to investigate the effects of radiofrequency
catheter ablation (RFCA) and clinical and electrophysiological characteristics in
symptomatic patients with premature ventricular contractions (PVCs) from near the
His-bundle (His-PVCs). METHODS: The patient characteristics, prevalence of
complications with any life style related disease (ALSRD) including hypertension,
dyslipidemia, or diabetes mellitus, and/or cardiovascular disease (CVD) including
coronary artery disease, cerebrovascular disease, renal dysfunction, or
cardiomyopathy, clinical status, frequency of PVCs evaluated by 24hour Holter
monitoring, echocardiography including the left ventricular diastolic dysfunction
(LVDD) parameters, and electrophysiological findings were evaluated in 14
consecutive symptomatic patients with His-PVCs. RESULTS: The prevalence of males,
being elderly and/or slightly obese, current and/or history of smoking, ALSRD or
CVD related complications, and LVDD probably resulting from ALSRD and/or CVD
complications were higher in patients with His-PVCs. RFCA of His-PVCs steadily
decreased the PVC frequency and improved the systolic function, LV dilation, and
clinical status, but not the LVDD. There was a significant relationship between the
accordance rate of the QRS polarity between sinus rhythm and His-PVCs and the
distance between the successful ablation site and His-bundle. CONCLUSION: The
analysis of the QRS duration and accordance rate of the QRS polarity between sinus
rhythm and His-PVCs before the RFCA may help to determine the distance between the
origin of the PVCs and His-bundle. Further, the appropriate ablation catheter may
be selected during the RFCA procedure. Finally, RFCA may be one of the most
effective, feasible, and safest therapies for symptomatic patients with His-PVCs.
AD - Cardiovascular Center Munakata Suikokai General Hospital Fukutsu Japan.
Cardiology Fukuoka Kinen Hospital Fukuoka Japan.
AN - 31007790
AU - Tanaka, A.
AU - Takemoto, M.
AU - Masumoto, A.
AU - Kang, H.
AU - Mito, T.
AU - Kumeda, H.
AU - Aoki, R.
AU - Kinoshita, S.
AU - Antoku, Y.
AU - Matsuo, A.
AU - Hida, S.
AU - Okazaki, T.
AU - Tayama, K. I.
AU - Kosuga, K. I.
C2 - PMC6457375
DA - Apr
DO - 10.1002/joa3.12167
DP - NLM
ET - 2019/04/23
IS - 2
KW - His‐bundle
catheter ablation
clinical characteristics
clinical status
premature ventricular contraction
LA - eng
N1 - 1883-2148
Tanaka, Atsushi
Takemoto, Masao
Orcid: 0000-0002-6047-9653
Masumoto, Akihiro
Kang, Honsa
Mito, Takahiro
Kumeda, Hiroshi
Aoki, Ryota
Kinoshita, Satoko
Antoku, Yoshibumi
Matsuo, Atsutoshi
Hida, Satoru
Okazaki, Teiji
Tayama, Kei-Ichiro
Kosuga, Ken-Ichi
Journal Article
J Arrhythm. 2019 Feb 15;35(2):252-261. doi: 10.1002/joa3.12167. eCollection 2019
Apr.
PY - 2019
SN - 1880-4276 (Print)
1880-4276
SP - 252-261
ST - Radiofrequency catheter ablation of premature ventricular contractions from
near the His-bundle
T2 - J Arrhythm
TI - Radiofrequency catheter ablation of premature ventricular contractions from
near the His-bundle
VL - 35
ID - 3140
ER -
TY - JOUR
AB - A 78-year-old man with Parkinson's disease, paroxysmal atrial fibrillation,
and congestive heart failure was admitted to our hospital due to global aphasia and
right-sided hemiparesis. A cardioembolic stroke from a left ventricular thrombus
was diagnosed; several days later, anticoagulants were started. On the seventh day,
the patient suddenly developed severe acidosis and kidney and liver dysfunction. He
died the following afternoon. Autopsy revealed an isolated celiac artery embolism
from the left ventricular thrombus. This is the first reported case of isolated
celiac artery embolism occurring after acute ischemic stroke.
AD - Department of Medicine, Kumamoto Rosai Hospital, Yatsushiro. u-
kopin@med.uoeh-u.ac.jp
AN - 17827850
AU - Tanaka, Y.
AU - Nakajima, M.
AU - Hirano, T.
AU - Uchino, M.
DP - NLM
ET - 2007/09/11
IS - 17
KW - Acidosis/etiology
Aged
*Celiac Artery
Fatal Outcome
Heart Diseases/*etiology
Heart Ventricles
Hepatic Insufficiency/etiology
Humans
Male
Parkinsonian Disorders/complications
Stroke/*etiology
Thrombosis/*etiology
LA - eng
N1 - 1349-7235
Tanaka, Yuko
Nakajima, Makoto
Hirano, Teruyuki
Uchino, Makoto
Case Reports
Journal Article
Japan
Sep 3.
PY - 2007
SN - 0918-2918
SP - 1463-6
ST - Cardioembolic stroke followed by isolated celiac artery thromboembolism
T2 - Intern Med
TI - Cardioembolic stroke followed by isolated celiac artery thromboembolism
VL - 46
ID - 2751
ER -
TY - JOUR
AB - BACKGROUND: A recently completed trial, the Canadian Trial of Physiological
Pacing (CTOPP), showed that physiological pacing did not significantly reduce
mortality, stroke, or heart failure hospitalization, but it did show that atrial
fibrillation occurred less frequently in patients with physiological pacing. Many
pacemaker patients experience only transient bradyarrhythmias with an adequate
unpaced heart rate (UHR) and are not pacemaker-dependent. The purpose of the
present analysis was to determine if pacemaker-dependent patients have an increased
benefit from physiological pacing compared with non-pacemaker-dependent patients.
METHODS AND RESULTS: Of 2568 patients included in the CTOPP trial, 2244 patients
had a pacemaker dependency test performed at the first follow-up visit. The yearly
event rate of cardiovascular death or stroke steadily increased with decreasing UHR
in the ventricular pacing group, but it remained constant in the physiological
pacing group. When the patients were subdivided to UHR </=60 bpm or >60 bpm, there
was an interaction between pacing mode treatment and UHR subgroup. The Kaplan-Meier
plot confirmed a physiological pacing advantage only in the UHR </=60 bpm subgroup.
This differential effect was also present for the outcomes of cardiovascular death
and total mortality. CONCLUSIONS: This study demonstrated that UHR at first follow-
up has an important influence on how pacing mode selection affects cardiovascular
death and total mortality. Pacemaker-dependent patients with low UHR will probably
be paced frequently and will likely benefit from physiological pacing. In contrast,
non-pacemaker-dependent patients will likely be paced infrequently and may not
benefit from physiological pacing.
AD - University of Ottawa Heart Institute, Ottawa, Ontario. atang@ottawaheart.ca
AN - 11425772
AU - Tang, A. S.
AU - Roberts, R. S.
AU - Kerr, C.
AU - Gillis, A. M.
AU - Green, M. S.
AU - Talajic, M.
AU - Yusuf, S.
AU - Abdollah, H.
AU - Gent, M.
DA - Jun 26
DO - 10.1161/01.cir.103.25.3081
DP - NLM
ET - 2001/06/27
IS - 25
J2 - Circulation
KW - Aged
Aged, 80 and over
Bradycardia/complications/*therapy
Cardiovascular Diseases/etiology/mortality
Female
Follow-Up Studies
Humans
Male
Middle Aged
Risk Factors
Stroke/etiology
Survival Analysis
LA - eng
N1 - 1524-4539
Tang, A S
Roberts, R S
Kerr, C
Gillis, A M
Green, M S
Talajic, M
Yusuf, S
Abdollah, H
Gent, M
Connolly, S J
Journal Article
United States
Circulation. 2001 Jun 26;103(25):3081-5. doi: 10.1161/01.cir.103.25.3081.
PY - 2001
SN - 0009-7322
SP - 3081-5
ST - Relationship between pacemaker dependency and the effect of pacing mode on
cardiovascular outcomes
T2 - Circulation
TI - Relationship between pacemaker dependency and the effect of pacing mode on
cardiovascular outcomes
VL - 103
ID - 2629
ER -
TY - JOUR
AB - Between April, 1979, and November, 1986, 20 patients underwent aortic valve
replacement (AVR) in the small aortic anulus with either 19 mm St. Jude Medical
valve prosthesis or 19 mm Duro-Medics valve prosthesis, which are relatively new,
low-profile bileaflet valve prostheses. There were two male and 18 female patients
ranging from 35 to 69 years old (mean, 54.7 years). Average body surface area was
1.37 +/- 0.11 m2 (range 1.20 to 1.55 m2). One patient died of arrhythmia at 22
postoperative day. The 19 survivors have been followed up for as long as 61 months
(mean, 31.2 months). There were two late complications, cerebral infarctions, and
event free ratio was 0.85 at five years. All long-term survivors were in New York
Heart Association Functional Class I (15 patients) and Class II (three patients).
Preoperative and postoperative echocardiograms demonstrated significant decreases
in mean left ventricular end-diastolic diameter (LVDd) (48.9 +/- 8.3 mm vs 42.2 +/-
5.7 mm; p less than 0.01) and in left ventricular end-systolic diameter (LVDs)
(32.2 +/- 8.2 mm vs 25.7 +/- 4.9 mm; p less than 0.01). Mean left ventricular wall
thickness was decreased to 24.5 +/- 3.7 mm from 25.8 +/- 6.4 mm. The average peak
systolic gradient at rest with Doppler ultrasound was 26.0 +/- 9.3 mmHg (range nine
to 36 mmHg). Though transprosthetic gradient did occur in patients who received 19
mm low-profile bileaflet valves in narrow aortic roots, progressive prosthetic
stenosis was not observed and small aortic prostheses provide acceptable palliation
for long-term results clinically.
AN - 2768922
AU - Terada, Y.
AU - Shiihara, H.
AU - Ino, T.
AU - Wanibuchi, Y.
AU - Furuta, S.
DA - Mar
DP - NLM
ET - 1989/03/01
IS - 3
J2 - [Zasshi] [Journal]. Nihon Kyobu Geka Gakkai
KW - Adult
Aged
Aortic Valve
Evaluation Studies as Topic
Female
Follow-Up Studies
*Heart Valve Prosthesis
Humans
Male
Middle Aged
Prognosis
Prosthesis Design
LA - jpn
N1 - Terada, Y
Shiihara, H
Ino, T
Wanibuchi, Y
Furuta, S
English Abstract
Journal Article
Japan
Nihon Kyobu Geka Gakkai Zasshi. 1989 Mar;37(3):470-7.
PY - 1989
SN - 0369-4739 (Print)
0369-4739
SP - 470-7
ST - [Long-term results of the 19 mm low-profile bileaflet valve prosthesis in the
small aortic anulus]
T2 - Nihon Kyobu Geka Gakkai Zasshi
TI - [Long-term results of the 19 mm low-profile bileaflet valve prosthesis in the
small aortic anulus]
VL - 37
ID - 3106
ER -
TY - JOUR
AB - Coronary angiography is the current gold standard for the diagnosis of
ischemic heart disease and therefore the prevalence of percutaneous coronary
procedures such as angiography and angioplasty is high. The occurrence of cerebral
complications after coronary angiography and coronary angioplasty is low and it
mainly includes transient ischemic attack and stroke. The prevalence of transient
cortical blindness after X-ray contrast media is low and it is usually seen after
cerebral angiography. Until now only a few cases of transient cortical blindness
have been described after coronary artery angiography. Regarding the spread of
coronary angiography worldwide and in Poland this complication is uniquely rare. A
32-year-old man with multiple extrasystolic ventricular arrhythmia suggesting
Brugada syndrome diagnosis according to morphology of the left bundle branch block
and with decreased left ventricular ejection fraction was admitted to the First
Department of Cardiology and Hypertension, Medical College of the Jagiellonian
University in Krakow. Coronary angiography was performed in order to exclude
ischemic etiology of the observed abnormalities. No arteriosclerotic lesions were
found in coronary arteries. Transient cortical blindness was observed directly
after angiography which may have been caused by the neurotoxic effect of the used
X-ray contrast medium. In ophthalmologic and neurologic examination as well as in
the cerebral computed tomography scan no pathologies were found. Visual impairment
disappeared totally within several hours.
AD - 1 Department of Cardiology and Hypertension, Jagiellonian University Medical
College, Krakow, Poland.
Department of Hematology, University Hospital, Krakow, Poland.
Department of Allergy and Immunology, 2 Chair in Internal Diseases, Jagiellonian
University Medical College, Krakow, Poland.
AN - 24570699
AU - Terlecki, M.
AU - Wojciechowska, W.
AU - Rajzer, M.
AU - Jurczyszyn, A.
AU - Bazan-Socha, S.
AU - Bryniarski, L.
AU - Czarnecka, D.
C2 - PMC3915953
DO - 10.5114/pwki.2013.34036
DP - NLM
ET - 2014/02/27
IS - 1
J2 - Postepy w kardiologii interwencyjnej = Advances in interventional cardiology
KW - contrast media
coronary angiography
cortical blindness
LA - eng
N1 - 1897-4295
Terlecki, Michał
Wojciechowska, Wiktoria
Rajzer, Marek
Jurczyszyn, Artur
Bazan-Socha, Stanisława
Bryniarski, Leszek
Czarnecka, Danuta
Case Reports
Postepy Kardiol Interwencyjnej. 2013;9(1):105-8. doi: 10.5114/pwki.2013.34036. Epub
2013 Mar 21.
PY - 2013
SN - 1734-9338 (Print)
1734-9338
SP - 105-8
ST - Transient cortical blindness after coronary artery angiography
T2 - Postepy Kardiol Interwencyjnej
TI - Transient cortical blindness after coronary artery angiography
VL - 9
ID - 3109
ER -
TY - JOUR
AN - 14216468
AU - Texeira, J.
DA - Sep-Oct
DP - NLM
ET - 1964/09/01
J2 - The Journal of cardiovascular surgery
KW - *Acidosis
*Acute Kidney Injury
Brazil
*Cause of Death
*Embolism
*Embolism, Fat
*Extracorporeal Circulation
*Heart Arrest
*Heart Block
*Heart Diseases
*Heart Septal Defects
*Heart Septal Defects, Ventricular
*Heart, Artificial
*Hemorrhage
Humans
*Infections
*Mortality
*Renal Insufficiency
*Respiratory Insufficiency
*Shock, Surgical
*Thoracic Surgery
*heart surgery
*heart, mechanical
*infection
*kidney failure, acute
LA - eng
N1 - Texeira, j
Journal Article
Italy
J Cardiovasc Surg (Torino). 1964 Sep-Oct;5:386-91.
PY - 1964
SN - 0021-9509 (Print)
0021-9509
SP - 386-91
ST - A STUDY OF MAJOR CAUSES OF DEATH FOLLOWING CARDIAC SURGERY WITH
EXTRACORPOREAL CIRCULATION. ANALYSIS OF 1,668 OPERATIONS PERFORMED IN BRAZIL
T2 - J Cardiovasc Surg (Torino)
TI - A STUDY OF MAJOR CAUSES OF DEATH FOLLOWING CARDIAC SURGERY WITH
EXTRACORPOREAL CIRCULATION. ANALYSIS OF 1,668 OPERATIONS PERFORMED IN BRAZIL
VL - 5
ID - 2974
ER -
TY - JOUR
AB - Chronic left ventricular systolic dysfunction is a well recognized problem
with an increasingly significant impact on healthcare in the form of congestive
heart failure (CHF). Advances in medicine have led to improved survival after
myocardial infarction (MI) and as a result, an increased prevalence of left
ventricular systolic dysfunction. An increased incidence of thromboembolism,
especially stroke, in patients with left ventricular systolic dysfunction is also
well recognized. Pharmacological strategies to prevent stroke have been proposed in
numerous studies. For example, anticoagulation in patients with atrial fibrillation
and heart failure has been shown to reduce mortality rates and the incidence of
stroke; however, its role in patients with left ventricular dysfunction and normal
sinus rhythm is unclear and utilization of anticoagulation in these patients varies
widely. The role of aspirin to prevent thromboembolism in patients with CHF is
controversial. The relatively new pharmacological agent ximelagatran, which has an
advantage of unmonitored oral administration has the potential to change the
anticoagulation strategy in patients with heart failure. Important trials to define
optimal therapy for reducing the risk of thromboembolism and death in patients with
left ventricular systolic dysfunction and sinus rhythm include the recently
reported WATCH (Warfarin and Antiplatelet Therapy in Chronic Heart failure) trial
and the WARCEF (Warfarin versus Aspirin in Reduced Cardiac Ejection Fraction)
trial, which is currently underway. The WATCH trial failed to outline significant
differences between aspirin (acetylsalicylic acid), warfarin, and clopidogrel in
the primary composite endpoint of all-cause mortality, nonfatal MI, and nonfatal
stroke. Combined data from WATCH and WARCEF may provide sufficient statistical
power to clarify outcomes such as stroke and death in patients with reduced cardiac
ejection fraction. The pooled data may also help define optimal preventative
measures for thromboembolism in patients with left ventricular systolic dysfunction
and sinus rhythm.
AD - Department of Cardiology, Veteran Affairs Medical Center, Detroit, Michigan
48201, USA. deepak.thatai@med.va.gov
AN - 16489847
AU - Thatai, D.
AU - Ahooja, V.
AU - Pullicino, P. M.
DO - 10.2165/00129784-200606010-00004
DP - NLM
ET - 2006/02/24
IS - 1
J2 - American journal of cardiovascular drugs : drugs, devices, and other
interventions
Atrial Fibrillation/etiology/prevention & control
Humans
Incidence
Risk Assessment
Stroke Volume/drug effects
Thromboembolism/complications/physiopathology/*prevention & control
LA - eng
N1 - Thatai, Deepak
Ahooja, Vineeta
Pullicino, Patrick M
Journal Article
Review
New Zealand
Am J Cardiovasc Drugs. 2006;6(1):41-9. doi: 10.2165/00129784-200606010-00004.
PY - 2006
SN - 1175-3277 (Print)
1175-3277
SP - 41-9
ST - Pharmacological prevention of thromboembolism in patients with left
ventricular dysfunction
T2 - Am J Cardiovasc Drugs
TI - Pharmacological prevention of thromboembolism in patients with left
ventricular dysfunction
VL - 6
ID - 2623
ER -
TY - JOUR
AB - In patients with an acute cerebrovascular insufficiency a great number of
disturbances of the cardiac rhythm is existing. In our investigations the absolute
arrhythmia with auricular fibrillation and flutter (21%), ventricular and
supraventricular extrasystoles (22%), atrioventricular blocks (13%) and patterns of
bundle-branch block (25%) are concerned. Disturbances of the repolarisation of
different size were present in 74% of all patients. A pathological QT-interval was
to be stated in 31% of the patients examined. In the decreased patients a greater
number of the disturbances of rhythm proved was to be observed. There were
significant differences in disturbances of repolarisation. We stated a tendency to
significance in the tachyarrhythmia. Apart from the sinus tachycardia the
atrioventricular blocks were particularly distinct in the cerebral haemorrhage. The
tachyarrhythmia was characteristic in patients with cerebral embolism. The mixed
form of the cerebrovascular insufficiency was associated with a sinus bradycardia -
above all as an expression of the cerebral pressure.
AD - Abteilung für Internistische Intensivtherapie, Friedrich-Schiller-Universität
Jena.
AN - 2470209
AU - Thiele, R.
AU - Stefan, V.
AU - Schneider, J.
AU - Meier, F.
AU - Wessel, G.
DA - Feb 15
DP - NLM
ET - 1989/02/15
IS - 4
J2 - Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete
KW - Arrhythmias, Cardiac/*complications
Atrial Flutter/complications
Cardiac Complexes, Premature/complications
Cerebral Hemorrhage/etiology
Heart Block/complications
Humans
Tachycardia/complications
LA - ger
N1 - Thiele, R
Stefan, V
Schneider, J
Meier, F
Wessel, G
English Abstract
Journal Article
Germany
Z Gesamte Inn Med. 1989 Feb 15;44(4):110-3.
OP - Elektrokardiographische Veränderungen bei Patienten mit einer akuten
zerebrovaskulären Insuffizienz.
PY - 1989
SN - 0044-2542 (Print)
0044-2542
SP - 110-3
ST - [Electrocardiography changes in patients with acute cerebrovascular
insufficiency]
T2 - Z Gesamte Inn Med
TI - [Electrocardiography changes in patients with acute cerebrovascular
insufficiency]
VL - 44
ID - 2748
ER -
TY - JOUR
AB - Cardiovascular disease, the major cause of death in the elderly, is mostly
ascribable to complications of coronary atherosclerosis: angina pectoris,
myocardial infarction, and sudden death. However, other degenerative diseases
involving several cardiac structures exist, and should be distinguished from age-
related cardiac changes. Extensive dystrophic calcification determines aortic
stenosis, and may affect either a normally tricuspid or a congenitally bicuspid
valve. Surgical valve replacement is now a low risk option, even in elderly
persons, whereas the efficacy of balloon valvuloplasty is questionable. Aortic
incompetence in adults and aged persons is mostly the consequence of aortic tunica
media atrophy with anular ectasia, in the setting of nearly normal aortic leaflets.
Mitral valve prolapse is the main cause of mitral incompetence; spontaneous cordal
rupture is a late complication in the natural history of this disease, thus
warranting prompt surgical valve repair or replacement. The entire spectrum of
cardiomyopathies is observed in the elderly: dilated, hypertrophic, restrictive,
arrhythmogenic. Cardiac amyloidosis is by far the most frequent secondary form and
leads to congestive heart failure by impairing ventricular compliance. Idiopathic
fibrosis of the specialized AV junction or dystrophic calcification of central
fibrous body are the usual substrates of AV block, which requires pace-maker
implantation. Nonrheumatic atrial fibrillation, due to fibro-fatty degeneration of
the atrial musculature or dilated left atrium, carries a high risk of
thromboembolic complications and cerebral accidents; oral anticoagulants have
proven to be effective in preventing stroke. Aortic dissecting aneurysm is a
spontaneous laceration, and usually a complication of longstanding systemic
hypertension; exceptionally, spontaneous dissection may primarily occur in the
coronary arteries. In conclusion, longevity at present is mostly threatened by
cardiovascular disease, among which the role of degenerative, non-atherosclerotic
disorders may be greater than thought.
AD - Institute of Pathological Anatomy, University of Padova Medical School,
Italy.
AN - 2094363
AU - Thiene, G.
AU - Valente, M.
DA - Sep
DO - 10.1007/bf03323924
DP - NLM
ET - 1990/09/01
IS - 3
J2 - Aging (Milan, Italy)
KW - Aged
Aging
Aneurysm, Dissecting/pathology
Aortic Aneurysm/pathology
Cardiomyopathies/pathology
Cardiovascular Diseases/*pathology
Coronary Aneurysm/pathology
Heart/growth & development
Heart Valve Diseases/pathology
Humans
LA - eng
N1 - Thiene, G
Valente, M
Journal Article
Review
Italy
Aging (Milano). 1990 Sep;2(3):231-44. doi: 10.1007/BF03323924.
PY - 1990
SN - 0394-9532 (Print)
0394-9532
SP - 231-44
ST - Degenerative, non-atherosclerotic cardiovascular disease in the elderly: a
clinico-pathological survey
T2 - Aging (Milano)
TI - Degenerative, non-atherosclerotic cardiovascular disease in the elderly: a
clinico-pathological survey
VL - 2
ID - 2932
ER -
TY - JOUR
AB - Current evidence indicates that heart failure (HF) confers a hyper-coagulable
state that is associated with adverse events including stroke, systemic embolism,
and mortality. This may be due to the elevated levels of pro-thrombotic and pro-
inflammatory cytokines that are seen in patients with acute and chronic HF. Left
ventricular wall motion abnormalities in patients with systolic dysfunction
predispose to local thrombosis due to blood stasis as does atrial fibrillation (AF)
which leads to blood stasis in regions of the atria. The high risk of thromboemboli
in HF patients with AF has resulted in the use anticoagulation therapy to prevent
the occurrence of catastrophic events. There is evidence, however, that the pro-
inflammatory, pro-thrombotic state that exists in HF puts patients who are in sinus
rhythm at risk. The novel oral anticoagulants (NOACs) have been shown in RCT to
have at least equivalent efficacy in reducing stroke as warfarin while exposing
patients to a lower risk of bleeding. The fact that the NOACs don't require routine
monitoring to assure that patients remain within the therapeutic range and have
relatively simple dosing requirements and a safer risk profile makes them
attractive substitutes to warfarin in HF patients with atrial fibrillation and
other conditions (e.g. deep venous thrombosis). Post hoc analyses from a subset of
HF patients from the RCTs in AF patients have demonstrated similar findings as were
reported in the entire populations that were included in the trials. As a result,
NOACS are commonly used now in HF patients with AF. For HF patients with reduced
ejection fraction in sinus rhythm, the use of warfarin in randomized clinical
trials (RCT) to reduce stroke has been disappointing and associated with increase
bleeding risk when compared to aspirin. The advantages of the NOACs over warfarin,
however, raise the question of whether they might improve outcomes in HF patients
who are in sinus rhythm. The currently ongoing COMMANDER-HF trial has been designed
to address this issue. In this chapter we review evidence of existence of a
prothombotic state in HF, the pharmacodynamics and clinical trials of the NOACs and
the outcomes from NOAC substudies in the HF subgroup. We also discuss the rationale
for using anticoagulation in HF independent of arrhythmia burden.
AD - Cardiology Division, Department of Medicine, University of California, San
Diego, 9444 Medical Center Drive, La Jolla, CA, 92034-7411, USA.
Cardiology Division, Department of Medicine, University of California, San Diego,
9444 Medical Center Drive, La Jolla, CA, 92034-7411, USA. bgreenberg@ucsd.edu.
AN - 28233177
AU - Thomas, I.
AU - EncisoSilva, J.
AU - Schlueter, M.
AU - Greenberg, B.
DO - 10.1007/164_2016_126
DP - NLM
ET - 2017/02/25
J2 - Handbook of experimental pharmacology
Antithrombins/therapeutic use
Dabigatran/therapeutic use
Factor Xa Inhibitors/therapeutic use
Humans
Pyridines/therapeutic use
Rivaroxaban/therapeutic use
Thiazoles/therapeutic use
Venous Thromboembolism/complications/drug therapy
*Bleeding
*Heart failure
*Novel oral anticoagulant
*Randomized clinical trials
*Stroke
*Thrombosis
LA - eng
N1 - Thomas, Isac
EncisoSilva, Jorge
Schlueter, Michelle
Greenberg, Barry
Journal Article
Review
Germany
Handb Exp Pharmacol. 2017;243:515-535. doi: 10.1007/164_2016_126.
PY - 2017
SN - 0171-2004 (Print)
0171-2004
SP - 515-535
ST - Anticoagulation Therapy and NOACs in Heart Failure
T2 - Handb Exp Pharmacol
TI - Anticoagulation Therapy and NOACs in Heart Failure
VL - 243
ID - 2288
ER -
TY - JOUR
AB - Atrial fibrillation (AF) is the most common clinically important cardiac
arrhythmia. It is an important cause of stroke, contributes to the burden of heart
failure and is a major contributor to health expenditure. Percutaneous catheter
ablation is superior to medical therapy in reducing AF recurrences. It has an
important role in treatment of patients with failed drug therapy. Successful
catheter ablation improves left ventricular function in patients with heart
failure. In addition, it may be appropriate for selected highly symptomatic
patients as first line therapy. Catheter ablation for AF has been shown in
randomised trials to reduce hospital admissions and improve quality of life. There
is evidence from registry data to suggest it reduces the risk of stroke and
improves mortality. Cost effectiveness has been demonstrated by modelling studies
in both Europe and the United States.
AD - Department of Cardiology, Westmead Hospital, University of Sydney and
Macquarie University, Australia. stuart.thomas@sydney.edu.au
AN - 22575531
AU - Thomas, S. P.
AU - Sanders, P.
DA - Jun
DO - 10.1016/j.hlc.2012.03.122
DP - NLM
ET - 2012/05/12
IS - 6-7
KW - Atrial Fibrillation/complications/epidemiology/physiopathology/*therapy
Catheter Ablation/adverse effects/*methods
Cost of Illness
Europe/epidemiology
Heart Failure/epidemiology/physiopathology/therapy
Humans
Quality of Life
Registries
Stroke/epidemiology/etiology/physiopathology/prevention & control
LA - eng
N1 - 1444-2892
Thomas, Stuart P
Sanders, Prashanthan
Journal Article
Review
Australia
Heart Lung Circ. 2012 Jun;21(6-7):395-401. doi: 10.1016/j.hlc.2012.03.122. Epub
2012 May 9.
PY - 2012
SN - 1443-9506
SP - 395-401
ST - Catheter ablation for atrial fibrillation
TI - Catheter ablation for atrial fibrillation
VL - 21
ID - 2473
ER -
TY - JOUR
AB - Commotio cordis or ventricular fibrillation caused by a blow to the chest is
a rare cause of cardiac arrest in a well child. We report a case of a young child
falling from a low height landing chest first with rapid onset of unconsciousness,
apnoea and cyanosis. Cardiopulmonary resuscitation was given by parents under
telephone instruction from an ambulance dispatch centre. On arrival of officers, 7
min after the fall, ventricular fibrillation was present but responded to
defibrillation (biphasic 3 J/kg). No clinical or CT evidence of chest or brain
trauma was present and investigations (ECGs, cardiac MRI, echocardiography, viral
tests, metabolic tests, drug tests, serum electrolytes) did not reveal any cardiac
illness or abnormal cardiac anatomy. Specifically, a long QT was absent and a
Flecainide challenge for Brugada syndrome was negative. There was no family history
of sudden death. No further dysrrhythmia occurred and the child recovered
neurologically well after 3 days of therapeutic hypothermia (for cerebral
ischaemia) and 7 days of mechanical ventilation.
AD - Intensive Care Unit, Royal Children's Hospital, Flemington Road, Parkville,
Melbourne, Victoria 3052, Australia. james.tibballs@rch.org.au
AN - 18164118
AU - Tibballs, J.
AU - Thiruchelvam, T.
DA - Apr
DP - NLM
ET - 2008/01/01
IS - 1
J2 - Resuscitation
KW - *Accidental Falls
Child, Preschool
Humans
Hypothermia, Induced
Male
Wounds, Nonpenetrating/*complications
LA - eng
N1 - Tibballs, James
Thiruchelvam, Timothy
Case Reports
Journal Article
Ireland
Resuscitation. 2008 Apr;77(1):139-41. doi: 10.1016/j.resuscitation.2007.10.013.
Epub 2007 Dec 27.
PY - 2008
SN - 0300-9572 (Print)
0300-9572
SP - 139-41
ST - A case of Commotio cordis in a young child caused by a fall
T2 - Resuscitation
TI - A case of Commotio cordis in a young child caused by a fall
VL - 77
ID - 2800
ER -
TY - JOUR
AB - The consensus on antithrombotic prophylaxis of vascular incidents in patients
with manifest atherosclerotic vasculopathy was preceded by a systematic
classification of results from relevant articles according to 'evidential value':
from randomized prospective trials of sufficient quality and size, via less
adequate or non-randomized trials to the current opinion in the Netherlands. The
principal advice was to prescribe antithrombotic prophylaxis, mostly
acetylsalicylic acid, for patients with manifest atherosclerotic vasculopathy (in
head, heart and (or) legs). With regard to the question what drug should be
preferred for patients with intermittent claudication, no consensus could be
reached for lack of adequate research. Acetylsalicylic acid is not more effective
in higher than in lower doses, but in higher doses it has more side effects;
therefore lower doses are preferred: 80-100 mg per day, and for neurological
indications, 30 mg or more per day. Use of coumarin derivates is only to be
preferred in patients with atrial fibrillation who have suffered a TIA or a non-
crippling cerebral infarction, in patients with atrial fibrillation and a cardiac
disorder such as large myocardial infarction or a left ventricular aneurysm, and in
patients who have undergone a cardiac valve operation. Since the proportion of pros
and cons of antithrombotic prophylaxis may change during a patient's life, the
indication should be reconsidered periodically.
AD - Academisch Medisch Centrum, afd. Klinische Epidemiologie en Biostatistiek,
Amsterdam.
AN - 9556999
AU - Tijssen, J. G.
DA - Jan 10
DP - NLM
ET - 1998/04/29
IS - 2
Arteriosclerosis/complications/*drug therapy
Cerebrovascular Disorders/prevention & control
Coronary Disease/prevention & control
Humans
Ischemic Attack, Transient/drug therapy
LA - dut
N1 - Tijssen, J G
English Abstract
Journal Article
Review
Netherlands
Ned Tijdschr Geneeskd. 1998 Jan 10;142(2):83-8.
OP - Consensus antitrombotische profylaxe van vasculaire gebeurtenissen bij
patiënten met manifeste atherosclerotische vaatziekte. Centraal Begeleidingsorgaan
voor de Intercollegiale Toetsing.
PY - 1998
SN - 0028-2162 (Print)
0028-2162
SP - 83-8
ST - [Consensus antithrombotic prophylaxis of vascular incidents in patients with
manifest atherosclerotic vascular diseases. Central Guidance Organization for Peer
Review]
TI - [Consensus antithrombotic prophylaxis of vascular incidents in patients with
manifest atherosclerotic vascular diseases. Central Guidance Organization for Peer
Review]
VL - 142
ID - 2695
ER -
TY - JOUR
AB - Exercise is, together with diet, a powerful health-promoting habit. However,
an association of intense physical activity with the onset of atrial and
ventricular arrhythmias, and sudden death has been described. Although initially
questioned, the atrial pro-arrhythmic role of endurance physical activity is now
well accepted in the scientific community. Atrial fibrillation is common among
endurance athletes, being a source of morbidity in otherwise healthy young and
middle-aged individuals. The mechanisms for its development are still poorly
understood, but likely involve some components of the athlete's heart (e.g.,
bradycardia, atrial enlargement) and some clearly pathological factors (e.g.,
atrial fibrosis). Its management must be a careful balance between exercise
moderation and cessation, as extremes in exercise practice have both been related
to atrial fibrillation. In this article, we review the current knowledge on
exercise-induced atrial fibrillation through different perspectives, each focusing
on the epidemiological evidence, the associated risk, the identification of
individuals at risk, the potential approach to reduce its impact and how should
these athletes be informed.
AD - Unit of Arrhythmia, Cardiovascular Institute, Hospital Clinic, University of
Barcelona, Barcelona, Spain.
Centro de Investigación Biomédica en Red Cardiovascular (CIBERCV), Madrid, Spain.
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona,
Spain.
Unit of Arrhythmia, Cardiovascular Institute, Hospital Clinic, University of
Barcelona, Barcelona, Spain - eguasch@clinic.cat.
AN - 31343147
AU - Tirapu, L.
AU - San Antonio, R.
AU - Tolosana, J. M.
AU - Roca-Luque, I.
AU - Mont, L.
AU - Guasch, E.
DA - Oct
DO - 10.23736/s0026-4725.19.04998-3
DP - NLM
ET - 2019/07/26
IS - 5
KW - Atrial Fibrillation/complications/*etiology/*therapy
*Exercise
Humans
Risk Factors
Sports
LA - eng
N1 - 1827-1618
Tirapu, Laia
San Antonio, Rodolfo
Tolosana, José M
Roca-Luque, Ivo
Mont, Lluís
Guasch, Eduard
Journal Article
Review
Italy
Minerva Cardioangiol. 2019 Oct;67(5):411-424. doi: 10.23736/S0026-4725.19.04998-3.
Epub 2019 Jul 24.
PY - 2019
SN - 0026-4725
SP - 411-424
ST - Exercise and atrial fibrillation: how health turns harm, and how to turn it
back
TI - Exercise and atrial fibrillation: how health turns harm, and how to turn it
back
VL - 67
ID - 2292
ER -
TY - JOUR
AB - AIMS: The aim of this study was to investigate whether minimising trauma to
the aortic annulus and left ventricular outflow tract reduces the occurrence of new
conduction disorders and the need for permanent pacemakers. METHODS AND RESULTS: A
total of 175 patients (58% female, mean age 83±6 years) underwent transfemoral TAVI
with the Boston Scientific ACURATE neo at three centres in Europe. Prosthesis size
selection was based on perimeter-derived annular diameter. Predilatation was
performed in all with a balloon 1.9±0.9 mm smaller than the perimeter-derived
annular diameter. Post-dilatation was performed in 46 (26.3%) with a balloon
1.2±0.9 mm smaller than the perimeter-derived annular diameter. Eighteen patients
(10.3%) developed a new left bundle branch block, 13 (7%) a new first-degree AV
block, and four (2.3%) received a new permanent pacemaker. Paravalvular
regurgitation was none/trace in 66 (37.7%), mild in 101 (57.7%) and moderate in
eight (4.6%). At 30 days, the rate of any stroke was 1.7% (3/175), and one patient
(0.6%) had died. CONCLUSIONS: With careful selection of the balloon and the ACURATE
neo prosthesis size, very low rates of new conduction disorders and permanent
pacemaker implantation may be achieved without increasing the amount of
paravalvular regurgitation.
AD - Heart Center Lucerne, Luzerner Kantonsspital, Lucerne, Switzerland.
AN - 28870877
AU - Toggweiler, S.
AU - Nissen, H.
AU - Mogensen, B.
AU - Cuculi, F.
AU - Fallesen, C.
AU - Veien, K. T.
AU - Brinkert, M.
AU - Kobza, R.
AU - Rück, A.
DA - Dec 20
DO - 10.4244/eij-d-17-00252
DP - NLM
ET - 2017/09/06
IS - 11
J2 - EuroIntervention : journal of EuroPCR in collaboration with the Working Group
on Interventional Cardiology of the European Society of Cardiology
KW - Aged
Aged, 80 and over
Aortic Valve/diagnostic imaging/physiopathology/*surgery
Aortic Valve Insufficiency/etiology
Aortic Valve Stenosis/diagnostic imaging/mortality/physiopathology/*surgery
Atrioventricular Block/diagnosis/etiology/physiopathology/*therapy
*Balloon Valvuloplasty/adverse effects/mortality
Bundle-Branch Block/diagnosis/etiology/physiopathology/*therapy
Europe
Female
Humans
Male
Prosthesis Design
Risk Factors
Stroke/etiology
Time Factors
Transcatheter Aortic Valve Replacement/adverse effects/*instrumentation/mortality
Treatment Outcome
LA - eng
N1 - 1969-6213
Toggweiler, Stefan
Nissen, Henrik
Mogensen, Brynjolfur
Cuculi, Florim
Fallesen, Christian
Veien, Karsten Tange
Brinkert, Miriam
Kobza, Richard
Rück, Andreas
Journal Article
Multicenter Study
France
EuroIntervention. 2017 Dec 20;13(11):1273-1280. doi: 10.4244/EIJ-D-17-00252.
PY - 2017
SN - 1774-024x
SP - 1273-1280
ST - Very low pacemaker rate following ACURATE neo transcatheter heart valve
implantation
T2 - EuroIntervention
TI - Very low pacemaker rate following ACURATE neo transcatheter heart valve
implantation
VL - 13
ID - 2524
ER -
TY - JOUR
AB - One hundred patients with focal cerebral ischaemic attacks of suspected
embolic origin were investigated by Holter monitoring to determine whether
paroxysmal arrhythmia may have been responsible for the episodes. There were 57 men
and 43 women aged from 16 to 79 years (mean 50 years). Ninety-seven had residual
focal neurological deficits and 3 had transient ischaemic attacks. The neurological
lesions were verified by cerebral angiography in 68. Twenty-one had arterial
hypertension and 9 had old myocardial infarction or angina. Nine had a history of
palpitations. None had cardiac valve disease. All patients were in sinus rhythm, 4
had ventricular extrasystoles on routine ECG, and 4 had supraventricular
extrasystoles. None of the patients were receiving anti-arrythmic drugs at the time
of investigation. Holter monitoring was performed for 18 hours in 91 cases and for
24-54 hours in the remaining ones. The interval between the cerebral ischaemic
attack and the monitoring was less than one month (mean 20 days) for 50 patients
and longer for the others. Cardiac arrythmias were found in 36 patients. Sixteen
had more than 10 supraventricular extrasystoles per hour, 13 had runs of 3 to 8
beats of supraventricular tachycardia, 1 had an episode of atrial fibrillation.
Eighteen subjects had more than 5 ventricular extrasystoles per hour, 1 had
accelerated ventricular rhythm, 2 had runs of 4 to 7 beats of ventricular
tachycardia. Two patients had second degree A.V. block. None had palpitations
during monitoring. Arrythmias were increasingly frequent with age. Our findings are
similar to those obtained with monitoring in ambulatory asympatomatic subjects of
the same age without apparent heart diseases reported by other authors. On the
other hand, the frequency of arrythmia was unrelated to the time elapsed between
the ischaemic attack and Holter monitoring. In conclusion, Holter monitoring
performed several weeks after suspected cerebral embolism failed to reveal
arrythmias likely to be responsible for a focal cerebral ischaemic attack.
AN - 6167934
AU - Tonet, J. L.
AU - Frank, R.
AU - Ducardonnet, A.
AU - Fillette, F.
AU - Fontaine, G.
AU - Komajda, M.
AU - Thomas, D.
AU - Bousser, M. G.
AU - Grosgogeat, Y.
DA - Jul 11-25
DP - NLM
ET - 1981/07/11
IS - 30
J2 - La Nouvelle presse medicale
KW - Adolescent
Adult
Aged
Atrial Fibrillation/diagnosis
Cardiac Complexes, Premature/diagnosis
Female
Heart Block/diagnosis
Humans
Male
Middle Aged
Time Factors
LA - fre
N1 - Tonet, J L
Frank, R
Ducardonnet, A
Fillette, F
Fontaine, G
Komajda, M
Thomas, D
Bousser, M G
Grosgogeat, Y
English Abstract
Journal Article
France
Nouv Presse Med. 1981 Jul 11-25;10(30):2491-4.
OP - L'enregistrement de Holter dans les accidents ischémiques cérébraux.
PY - 1981
SN - 0301-1518 (Print)
0301-1518
SP - 2491-4
ST - [Holter monitoring in patients with focal cerebral ischaemic attacks
(author's transl)]
T2 - Nouv Presse Med
TI - [Holter monitoring in patients with focal cerebral ischaemic attacks
(author's transl)]
VL - 10
ID - 2387
ER -
TY - JOUR
AB - The risk of systemic embolism and stroke in patients with non-rheumatic
atrial fibrillation (NRAF) should not be underestimated. The annual embolic rate is
approximately 5% and in those with left atrial enlargement and/or left ventricular
(LV) dysfunction, or who have already had systemic embolism, this rate may be as
high as 20%. Decisions on patient management and the prophylaxis of stroke must
always be individualised. The risk of bleeding related to warfarin is almost
certainly greater than that encountered in the previous randomised trials. Also,
clinical and echocardiographic features can further define absolute risk in an
individual patient with NRAF. Clinical markers of increased risk of embolism in
patients with NRAF include older age, previous cerebral embolism, recent congestive
heart failure, hypertension and diabetes mellitus. Transthoracic echocardiography
improves risk stratification and should be performed in the vast majority of
patients. Embolic risk is greatest in those with increasing left atrial dilation,
atrial dysfunction and LV dysfunction. Transoesophageal echocardiography sharpens
the risk profile in selected patients. Overall randomised trials show greater
benefit with warfarin than aspirin. In general, increasing age is associated with a
greater incidence of structural heart disease and probably implies greater
potential benefit with warfarin. Increasing age per se may not increase the risk of
warfarin-related bleeding. When the decision is made to warfarinise patients, at
the present time data suggest that the target INR should be in the range of 2.0-
3.0.
AD - Austin and Repatriation Medical Centre, Melbourne, Vic.
AN - 10868521
AU - Tonkin, A.
DA - Jun
DO - 10.1111/j.1445-5994.1999.tb00744.x
DP - NLM
ET - 2000/06/27
IS - 3
J2 - Australian and New Zealand journal of medicine
Humans
Risk Assessment
Risk Factors
LA - eng
N1 - Tonkin, A
Journal Article
Australia
Aust N Z J Med. 1999 Jun;29(3):467-72. doi: 10.1111/j.1445-5994.1999.tb00744.x.
PY - 1999
SN - 0004-8291 (Print)
0004-8291
SP - 467-72
ST - Non-rheumatic atrial fibrillation and stroke
T2 - Aust N Z J Med
TI - Non-rheumatic atrial fibrillation and stroke
VL - 29
ID - 2601
ER -
TY - JOUR
AB - OBJECTIVES AND METHODS: End stage renal disease (ESRD) patients exhibit a
higher risk of cerebrovascular events as compared with the general population. In
283 ESRD patients followed up for 10 years, we investigated the long-term
predictive value for stroke and transient ischemic attacks of traditional and
nontraditional risk factors. Data analysis was performed by a modified Cox
regression analysis for repeated events and by a competing risks analysis. RESULTS:
During the follow-up, 61 cerebrovascular events occurred in 47 patients. On
univariate Cox analysis, the risk of cerebrovascular outcomes was directly related
to age, smoking, diabetes, BMI, systolic and pulse pressures, triglycerides,
hemoglobin, history of stroke/transient ischemic attacks, arrhythmia and left
ventricular mass index. Nontraditional risk factors in ESRD such as norepinephrine,
homocysteine, interleukin-6 and asymmetric dimethylarginine failed to predict these
events. In a multivariate Cox model for repeated events only smoking [hazard ratio:
2.45, 95% confidence interval (CI): 1.29-4.65], age (hazard ratio: 1.05, 95% CI:
1.01-1.08), hemoglobin (hazard ratio: 1.28, 95% CI 1.06-1.54), triglycerides
(hazard ratio: 1.04, 95% CI 1.01-1.08), pulse pressure (hazard ratio: 1.53, 95% CI
1.01-2.23) and left ventricular mass index (hazard ratio: 1.02, 95% CI 1.01-1.04)
maintained an independent relationship with cerebrovascular events. The direct link
between hemoglobin and cerebrovascular events was significantly stronger (P < 0.05)
than that of the same variable and death. CONCLUSION: The risk of stroke in ESRD
depends mainly on traditional risk factors, high hemoglobin and left ventricular
hypertrophy. Multiple interventions aimed to reduce arterial stiffness, left
ventricular mass and smoking as well as to maintain hemoglobin within the
recommended therapeutic range may have beneficial effects on the risk of
cerebrovascular events in ESRD patients.
AD - CNR-IBIM, Reggio Calabria, Italy.
AN - 20724936
AU - Tripepi, G.
AU - Mattace-Raso, F.
AU - Rapisarda, F.
AU - Stancanelli, B.
AU - Malatino, L.
AU - Witteman, J.
AU - Zoccali, C.
AU - Mallamaci, F.
DA - Dec
DO - 10.1097/HJH.0b013e32833eaf49
DP - NLM
ET - 2010/08/21
IS - 12
J2 - Journal of hypertension
KW - Aged
Blood Pressure
Cohort Studies
Female
Humans
Kidney Failure, Chronic/*complications/physiopathology
Male
Middle Aged
Risk Factors
LA - eng
N1 - 1473-5598
Tripepi, Giovanni
Mattace-Raso, Francesco
Rapisarda, Francesco
Stancanelli, Benedetta
Malatino, Lorenzo
Witteman, Jacqueline
Zoccali, Carmine
Mallamaci, Francesca
Journal Article
England
J Hypertens. 2010 Dec;28(12):2468-74. doi: 10.1097/HJH.0b013e32833eaf49.
PY - 2010
SN - 0263-6352
SP - 2468-74
ST - Traditional and nontraditional risk factors as predictors of cerebrovascular
events in patients with end stage renal disease
T2 - J Hypertens
TI - Traditional and nontraditional risk factors as predictors of cerebrovascular
events in patients with end stage renal disease
VL - 28
ID - 2568
ER -
TY - JOUR
AB - The prevalence and clinical significance of left atrial (LA) spontaneous echo
contrast were investigated in 103 consecutive patients with chronic nonrheumatic
atrial fibrillation (AF) using transesophageal echocardiography. LA spontaneous
echo contrast was visualized in 25 of 103 patients (24.3%). Age, sex, LA diameter,
left ventricular diastolic and systolic dimensions, left ventricular ejection
fraction, and the percentage of lone AF were not significantly different between
patients with and without LA spontaneous echo contrast; however, those with LA
spontaneous echo contrast were less likely to have moderate or severe mitral
regurgitation. LA thrombi were observed in 7 patients (6.8%), and all 7 thrombi
were found in the atria with spontaneous echo contrast. History of cerebral
ischemia or peripheral embolism, or both, was significantly more frequent in
patients with than without LA spontaneous echo contrast (84 vs 18%; p less than
0.001). The presence of LA spontaneous echo contrast was highly specific (94%) and
predictive for thromboembolic events (positive and negative predictive values of 84
and 82%, respectively). Thus, transesophageal echo-detected LA spontaneous echo
contrast is frequently found in patients with chronic nonrheumatic AF. This
phenomenon may represent a precursor of thrombus formation, and its presence is
associated with an increased thromboembolic risk.
AD - Department of Internal Medicine, National Cheng Kung University Medical
College and Hospital, Tainan, Taiwan, Republic of China.
AN - 1632397
AU - Tsai, L. M.
AU - Chen, J. H.
AU - Fang, C. J.
AU - Lin, L. J.
AU - Kwan, C. M.
DA - Aug 1
DO - 10.1016/0002-9149(92)90613-4
DP - NLM
ET - 1992/08/01
IS - 3
KW - Adult
Aged
Aged, 80 and over
Atrial Fibrillation/*diagnostic imaging/etiology
Chronic Disease
*Echocardiography
Female
Heart Diseases/complications/diagnostic imaging
Humans
Male
Middle Aged
Thromboembolism/complications/diagnostic imaging
LA - eng
N1 - Tsai, L M
Chen, J H
Fang, C J
Lin, L J
Kwan, C M
Journal Article
United States
Am J Cardiol. 1992 Aug 1;70(3):327-31. doi: 10.1016/0002-9149(92)90613-4.
PY - 1992
SN - 0002-9149 (Print)
0002-9149
SP - 327-31
ST - Clinical implications of left atrial spontaneous echo contrast in
nonrheumatic atrial fibrillation
T2 - Am J Cardiol
TI - Clinical implications of left atrial spontaneous echo contrast in
nonrheumatic atrial fibrillation
VL - 70
ID - 2912
ER -
TY - JOUR
AB - BACKGROUND: Patients with heart failure (HF) have increased risk for
thromboembolic events. Real-world incidences of efficacy and safety outcomes of
direct oral anticoagulants (DOACs) in patients with left ventricular systolic
dysfunction (LVSD) are of growing clinical interest. HYPOTHESIS: Real-world
efficacy and safety outcomes of DOACs in patients with LVSD will be similar to
those of LVSD or HF subgroups in the RE-LY, ROCKET-AF, and ARISTOTLE trials.
METHODS: We performed a retrospective review of adult patients with LVSD (left
ventricular ejection fraction ≤40%) on DOAC therapy between 2010 and 2016.
Incidences of safety and efficacy outcomes of anticoagulation with DOACs were
extracted from primary and secondary hospital discharge diagnoses. RESULTS: DOACs
were prescribed to 287 patients with LVSD over a mean follow-up of 313.3 ± 52.3
days. Many patients had moderate and severe chronic kidney disease (28.9% and
10.1%, respectively) and indications for anticoagulation therapy other than atrial
fibrillation (19.9%). For efficacy outcomes, the calculated incidence rates of
ischemic stroke and systemic embolism were 1.2 (95% confidence interval [CI]: 0.25-
3.56) and 0.81 (95% CI: 0.10-2.94) events per 100 person-years, respectively. For
the safety outcomes, incidence rates of GI bleeding and intracranial hemorrhage
were 2.4 (95% CI: 0.8-5.3) and 0.41 (95% CI: 0.1-2.2) events per 100 patient-years,
respectively. CONCLUSIONS: Our findings are largely compatible with the results of
LVSD or HF subgroups in RE-LY, ROCKET-AF, and ARISTOTLE trials and add to
increasing confidence that DOACs can be safely used for stroke and systemic
embolism prevention in patients with LVSD.
AD - Department of Internal Medicine, Mayo Clinic, Scottsdale, Arizona.
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota.
Division of Cardiovascular Diseases, Mayo Clinic, Scottsdale, Arizona.
Department of Advanced Heart Failure and Transplantation, David Geffen School of
Medicine, University of California, Los Angeles.
AN - 29247519
AU - Tseng, A. S.
AU - William Schleifer, J.
AU - Shen, W. K.
AU - McBane, R.
AU - Mankad, S.
AU - Esser, H.
AU - Vucicevic, D.
AU - Shamoun, F. E.
C2 - PMC6490385
DA - Dec
DO - 10.1002/clc.22833
DP - NLM
ET - 2017/12/17
IS - 12
Aged
Atrial Fibrillation/*complications/drug therapy
Female
Follow-Up Studies
Heart Ventricles/diagnostic imaging/*physiopathology
Hospital Mortality/trends
Humans
Incidence
Male
Middle Aged
Minnesota/epidemiology
Prognosis
Systole
Tertiary Care Centers/*statistics & numerical data
Thromboembolism/epidemiology/etiology/*prevention & control
Ventricular Dysfunction, Left/*epidemiology/etiology/physiopathology
Ventricular Function, Left/*drug effects
Direct Oral Anticoagulants
Efficacy
Safety
LA - eng
N1 - 1932-8737
Tseng, Andrew S
Orcid: 0000-0002-9181-1970
William Schleifer, J
Shen, Win-Kuang
McBane, Robert
Mankad, Sunil
Esser, Heidi
Vucicevic, Darko
Shamoun, Fadi E
Journal Article
Clin Cardiol. 2017 Dec;40(12):1328-1332. doi: 10.1002/clc.22833. Epub 2017 Dec 16.
PY - 2017
SN - 0160-9289 (Print)
0160-9289
SP - 1328-1332
ST - Real-world incidence of efficacy and safety outcomes in patients on direct
oral anticoagulants with left ventricular systolic dysfunction at a tertiary
referral center
T2 - Clin Cardiol
TI - Real-world incidence of efficacy and safety outcomes in patients on direct
oral anticoagulants with left ventricular systolic dysfunction at a tertiary
referral center
VL - 40
ID - 3020
ER -
TY - JOUR
AB - OBJECTIVE: To evaluate cardiac function using echocardiography in patients
with stroke admitted to subacute rehabilitation units. DESIGN: Retrospective,
cross-sectional study. PARTICIPANTS: A total of 750 consecutive patients with
stroke who were admitted to a suburban rehabilitation hospital. Mean age 67.5 years
(standard deviation (SD) 12.3 years). Mean time since stroke 36.7 days (SD 13.2
days). METHODS: Patients were assessed using transthoracic echocardiography within
7 days of admission. The prevalence of echocardiographic abnormalities was analysed
and compared between cerebral infarction and haemorrhage using the Mantel-Haenszel
method controlled for age. RESULTS: Arrhythmias were found in 13.7% of the
patients, 94.2% of whom had atrial fibrillation. Left atrial enlargement and left
ventricular hypertrophy were found in 20.4% and 19.5% of all patients,
respectively. Left ventricular asynergy was detected in 6.1% of all patients, but
47.8% of them had no history of myocardial infarction. Left ventricular ejection
fraction was low in 12.2% of all patients. Abnormal rhythms and left atrial
enlargement were significantly more frequent in patients with cerebral infarction
than in those with cerebral haemorrhage (p < 0.01). CONCLUSION: The prevalence of
cardiac problems is high among patients with subacute stroke regardless of a
history of heart disease, and this should be taken into account when planning
rehabilitation programmes.
AD - Department of Rehabilitation Medicine, Keio University School of Medicine, ,
Japan.
AN - 25188713
AU - Tsujikawa, M.
AU - Otaka, Y.
AU - Hasegawa, R.
AU - Kondo, K.
AU - Liu, M.
DA - Jan
DO - 10.2340/16501977-1890
DP - NLM
ET - 2014/09/05
IS - 1
J2 - Journal of rehabilitation medicine
KW - Aged
Aged, 80 and over
Arrhythmias, Cardiac/diagnostic imaging/epidemiology
Comorbidity
Female
Heart Diseases/*diagnostic imaging/epidemiology
Humans
Hypertrophy, Left Ventricular/diagnostic imaging/epidemiology
Japan/epidemiology
Male
Middle Aged
Myocardial Infarction/diagnostic imaging/epidemiology
Prevalence
Stroke/*diagnostic imaging/epidemiology
*Stroke Rehabilitation
Ultrasonography
LA - eng
N1 - 1651-2081
Tsujikawa, Masahiro
Otaka, Yohei
Hasegawa, Rei
Kondo, Kunitsugu
Liu, Meigen
Journal Article
Sweden
J Rehabil Med. 2015 Jan;47(1):38-44. doi: 10.2340/16501977-1890.
PY - 2015
SN - 1650-1977
SP - 38-44
ST - Echocardiographic abnormalities in patients with stroke during the subacute
rehabilitation phase
T2 - J Rehabil Med
TI - Echocardiographic abnormalities in patients with stroke during the subacute
rehabilitation phase
VL - 47
ID - 2384
ER -
TY - JOUR
AB - BACKGROUND: Atrial fibrillation (AF) is associated with worse outcomes
following ischemic stroke and more frequent cardiac complications in the general
population. We aimed to establish whether early cardiac complications contribute to
the poorer ischemic stroke outcomes in patients with AF, independent of baseline
differences in age, stroke severity and cardiovascular risk factors. This might
have important implications for acute stroke management in patients with AF.
METHODS: We searched VISTA-Acute, an academic database containing standardized data
for 28,131 patients from 30 randomized-controlled acute stroke trials and 1 stroke
registry, for imaging-confirmed placebo-treated patients with complete
documentation of baseline demographics, cardiovascular risk factors, presence or
absence of AF, neurologic impairment [National Institutes of Health Stroke Scale
(NIHSS)], cardiac complications and 3-month outcome (modified Rankin Scale). A
total of 2,865 patients from 6 randomized-controlled trials met the selection
criteria, of whom 819 had AF. Binary logistic regression modeling was used to
determine the independent effect of AF on stroke outcome and serious cardiac
adverse events (SCAE), a composite end point including acute coronary syndrome,
symptomatic heart failure, cardiopulmonary arrest, ventricular tachycardia,
ventricular fibrillation and cardiac mortality. RESULTS: All patients were enrolled
into the source trials within 24 h of stroke onset. At baseline, patients with AF
were older (mean 75 vs. 67 years, p < 0.001) and had greater neurologic impairment
(median NIHSS 15 vs. 13, p < 0.001). The median time to first cardiac adverse event
was 3 days [median difference 0, 95% confidence interval (CI) 0-1, p = 0.06] for
both patients with and without AF. SCAE occurred more frequently [14.2 vs. 6%, odds
ratio (OR) = 2.58, 95% CI 1.97-3.37] in patients with AF, particularly cardiac
mortality (4.9 vs. 2.6%, OR = 1.89, 95% CI 1.25-2.88), symptomatic heart failure
(6.5 vs. 2.2%, OR = 3.01, 95% CI 2.01-4.50), and ventricular tachycardia and/or
fibrillation (2.4 vs. 0.8%, OR = 3.18, 95% CI 1.64-6.16). At 3 months, AF was
independently associated with SCAE (OR = 2.14, 95% CI 1.61-2.86) and early
mortality (OR = 1.44, 95% CI 1.14-1.81) after adjusting for all baseline
imbalances. CONCLUSION: Early SCAE are common after stroke and are independently
associated with the presence of AF. Given that many cardiac complications are
potentially remediable, these results highlight the need for more rigorous
surveillance for cardiac complications in acute ischemic stroke patients with AF.
AD - University Department of Medicine, University of Melbourne, Melbourne, Vic.,
Australia.
AN - 22005390
AU - Tu, H. T.
AU - Campbell, B. C.
AU - Churilov, L.
AU - Kalman, J. M.
AU - Lees, K. R.
AU - Lyden, P. D.
AU - Shuaib, A.
AU - Donnan, G. A.
AU - Davis, S. M.
DO - 10.1159/000332028
DP - NLM
ET - 2011/10/19
IS - 5
KW - Acute Coronary Syndrome/epidemiology
Aged
Aged, 80 and over
Female
Humans
Incidence
Male
Middle Aged
Prognosis
Risk Factors
Stroke/*complications/*diagnosis/mortality
LA - eng
N1 - 1421-9786
Tu, Hans T H
Campbell, Bruce C V
Churilov, Leonid
Kalman, Jonathan M
Lees, Kennedy R
Lyden, Patrick D
Shuaib, Ashfaq
Donnan, Geoffrey A
Davis, Stephen M
VISTA collaborators
CZG/2/475/Chief Scientist Office/United Kingdom
G0200583/Medical Research Council/United Kingdom
Journal Article
Switzerland
Cerebrovasc Dis. 2011;32(5):454-60. doi: 10.1159/000332028. Epub 2011 Oct 14.
PY - 2011
SN - 1015-9770
SP - 454-60
ST - Frequent early cardiac complications contribute to worse stroke outcome in
atrial fibrillation
TI - Frequent early cardiac complications contribute to worse stroke outcome in
atrial fibrillation
VL - 32
ID - 2673
ER -
TY - JOUR
AB - Coronary artery aneurysm, especially left main coronary artery (LMCA)
aneurysm is a rare phenomenon. The disease may be congenital or acquired. The most
common cause of coronary artery aneurysm is atherosclerosis. We presented a man
with a large LMCA aneurysm presenting with unstable angina, transient ischemic
attack, ventricular tachycardia and paroxysmal atrial fibrillation.
AD - Cardiology Division, Faculty of Medicine, Cardiology Hospital of Hanefi
Oksuz, Kahramanmaras Sutcuimam University, Kahramanmaras, Turkey.
cetuncer@yahoo.com
AN - 16328854
AU - Tuncer, C.
AU - Sokmen, G.
AU - Sokmen, A.
AU - Guven, A.
DA - Jun-Aug
DO - 10.1007/s10554-005-9025-z
DP - NLM
ET - 2005/12/06
IS - 3-4
KW - Adult
Angina, Unstable/etiology
Coronary Aneurysm/*complications
Disease Progression
Electrocardiography
Humans
Male
Tachycardia, Ventricular/*etiology
LA - eng
N1 - Tuncer, Cemal
Sokmen, Gulizar
Sokmen, Abdullah
Guven, Aytekin
Case Reports
Journal Article
United States
Int J Cardiovasc Imaging. 2006 Jun-Aug;22(3-4):317-20. doi: 10.1007/s10554-005-
9025-z. Epub 2005 Nov 22.
PY - 2006
SN - 1569-5794 (Print)
1569-5794
SP - 317-20
ST - Aneurysm involving bifurcation of left main coronary artery presenting with
transient ischemic attack, paroxysmal atrial fibrillation and ventricular
tachycardia
TI - Aneurysm involving bifurcation of left main coronary artery presenting with
transient ischemic attack, paroxysmal atrial fibrillation and ventricular
tachycardia
VL - 22
ID - 2698
ER -
TY - JOUR
AB - AIMS: Catheter ablation of atrial fibrillation (AF) in patients with heart
failure (HF) can improve left ventricular (LV) function and HF symptoms. We aimed
to investigate whether long-term maintenance of sinus rhythm impacts on hard
outcomes such as stroke and death. METHODS AND RESULTS: An international
multicentre registry was compiled from seven centres for consecutive patients
undergoing catheter ablation of AF. Long-term freedom from AF was examined in
patients with and without HF. The impact of maintaining sinus rhythm on rates of
stroke and death was also examined. A total of 1273 patients were included: 171
with HF and 1102 without. Median follow-up was 3.1 years (IQR 2.0-4.3). The final
procedure success rate was no different for paroxysmal AF (PAF) (78.7 vs. 85.7%, P
= 0.186), but significantly different for persistent AF (57.3 vs. 75.8%, P <
0.001). Multivariate analysis showed that HF independently predicted recurrent
arrhythmia [hazard ratio (HR) 1.7, 95% confidence interval (CI) 1.2-2.4, P =
0.002]. New York Heart Association class decreased from 2.3 ± 0.7 at baseline to
1.5 ± 0.8 at follow-up (P < 0.001). Left ventricular ejection fraction (LVEF)
increased from 34.3 ± 9.0 to 45.8 ± 12.8% (P < 0.001). Recurrent AF was strongly
predictive of stroke or death in HF patients (HR 8.33, 95% CI 1.86-37.7, P =
0.001). CONCLUSION: Long-term success rates for persistent (but not paroxysmal) AF
ablation are significantly lower in HF patients. Left ventricular function and HF
symptoms were improved following ablation. In HF patients, recurrent arrhythmia
strongly predicted stroke and death during follow-up.
AD - Department of Arrhythmia Services, The Barts Heart Centre, St Bartholomew's
Hospital, Barts Health NHS Trust, London, UK.
Department of Arrhythmia Services, The Barts Heart Centre, St Bartholomew's
Hospital, Barts Health NHS Trust, London, UK The University of Melbourne and the
Baker Heart Research Institute, Melbourne, Australia.
The University of Melbourne and the Baker Heart Research Institute, Melbourne,
Australia.
Hospital, Barts Health NHS Trust, London, UK The London AF centre, London Bridge
Hospital, London, UK.
Oxford University Hospitals NHS Trust John Radcliffe Hospital, Oxford, UK.
Bristol Heart Institute, Bristol, UK.
NUH Hospitals Trust, Nottingham, UK.
Hospital, Barts Health NHS Trust, London, UK The London AF centre, London Bridge
Hospital, London, UK ross.hunter@bartshealth.nhs.uk.
AN - 26843584
AU - Ullah, W.
AU - Ling, L. H.
AU - Prabhu, S.
AU - Lee, G.
AU - Kistler, P.
AU - Finlay, M. C.
AU - Earley, M. J.
AU - Sporton, S.
AU - Bashir, Y.
AU - Betts, T. R.
AU - Rajappan, K.
AU - Thomas, G.
AU - Duncan, E.
AU - Staniforth, A.
AU - Mann, I.
AU - Chow, A.
AU - Lambiase, P.
AU - Schilling, R. J.
AU - Hunter, R. J.
DA - May
DO - 10.1093/europace/euv440
DP - NLM
ET - 2016/02/05
IS - 5
KW - Aged
Australia
*Catheter Ablation
Female
Heart Failure/*mortality/surgery
Humans
Male
Middle Aged
Perioperative Period
Recurrence
Registries
Stroke/*mortality/prevention & control
Stroke Volume
Survival Analysis
Treatment Outcome
United Kingdom
Af
Catheter ablation
Heart failure
Mortality
Outcome
Stroke
LA - eng
N1 - 1532-2092
Ullah, Waqas
Ling, Liang-Han
Prabhu, Sandeep
Lee, Geoffrey
Kistler, Peter
Finlay, Malcolm C
Earley, Mark J
Sporton, Simon
Bashir, Yaver
Betts, Tim R
Rajappan, Kim
Thomas, Glyn
Duncan, Edward
Staniforth, Andrew
Mann, Ian
Chow, Anthony
Lambiase, Pier
Schilling, Richard J
Hunter, Ross J
Journal Article
Multicenter Study
England
Europace. 2016 May;18(5):679-86. doi: 10.1093/europace/euv440. Epub 2016 Feb 3.
PY - 2016
SN - 1099-5129
SP - 679-86
ST - Catheter ablation of atrial fibrillation in patients with heart failure:
impact of maintaining sinus rhythm on heart failure status and long-term rates of
stroke and death
T2 - Europace
TI - Catheter ablation of atrial fibrillation in patients with heart failure:
impact of maintaining sinus rhythm on heart failure status and long-term rates of
stroke and death
VL - 18
ID - 2340
ER -
TY - JOUR
AB - BACKGROUND: Transcatheter aortic valve implantation (TAVI) carries higher
risk of post-procedural adverse events than conventional percutaneous
cardiovascular interventions. We report our experience about postoperative
management protocol adopted in our Division. METHODS: One hundred and ten patients
underwent TAVI and 108 were transferred to the cardiac intensive care unit (CICU)
after procedure. During the first 48 hours, vital parameters were monitored
continuously. Close attention was given to rhythm and atrio-ventricular conduction
disturbances, systemic blood pressure, fluid balance and vascular accesses.
RESULTS: The most common complications were renal impairment (21.3%), femoral
artery pseudo-aneurysms (FAP) (11%), new complete atrioventricular block (20.3 %),
cerebral vascular accident (4.5%) and cardiac perforation due to temporary
pacemaker lead (1.8%). Ultrasound-guided compression repair was considered the
first line treatment for FAP, but in 6 cases surgical treatment was immediately
performed due to the rapid expansion of FAP. Complete atrio-ventricular block
occurred in 22 patients (20.3 %) within the first 24 hours after TAVI and a
permanent pacemaker was implanted in 21 patients (19.1%). Acute kidney injury
occurred in 18 patients (35%) with pre-procedural chronic renal failure and in 5
patients (9%) without preoperative renal dysfunction. CONCLUSIONS: After TAVI,
cardiovascular complications are common and therefore accurate standardized
management of patients in CICU during the first 48 hours is mandatory to early
detect and manage complications and to decrease the rate of adverse events and the
length of in-hospital stay. © 2010 Wiley-Liss, Inc.
AD - Division of Cardiology, Ferrarotto Hospital, University of Catania, Italy.
gpussia@hotmail.com
AN - 20506545
AU - Ussia, G. P.
AU - Scarabelli, M.
AU - Mulè, M.
AU - Barbanti, M.
AU - Cammalleri, V.
AU - Immè, S.
AU - Aruta, P.
AU - Pistritto, A. M.
AU - Carbonaro, A.
AU - Deste, W.
AU - Sciuto, P.
AU - Licciardello, G.
AU - Calvi, V.
AU - Tamburino, C.
DA - Nov 1
DO - 10.1002/ccd.22602
DP - NLM
ET - 2010/05/28
IS - 5
KW - Acute Kidney Injury/etiology/therapy
Aged
Aged, 80 and over
Aneurysm, False/etiology/therapy
Aortic Valve Stenosis/diagnostic imaging/*therapy
Atrioventricular Block/etiology/therapy
*Bioprosthesis
Bundle-Branch Block/etiology
Cardiac Catheterization/adverse effects/*instrumentation/mortality
Cardiovascular Diseases/*etiology/therapy
Female
Femoral Artery
Heart Injuries/etiology/surgery
Heart Valve Prosthesis Implantation/adverse effects/*instrumentation/mortality
Humans
Italy
Male
Pericardiocentesis
Prosthesis Design
Radiography
Stroke/etiology
Time Factors
Treatment Outcome
LA - eng
N1 - 1522-726x
Ussia, Gian Paolo
Scarabelli, Marilena
Mulè, Massimiliano
Barbanti, Marco
Cammalleri, Valeria
Immè, Sebastiano
Aruta, Patrizia
Pistritto, Anna Maria
Carbonaro, Alessandro
Deste, Wanda
Sciuto, Paolo
Licciardello, Giovanni
Calvi, Valeria
Tamburino, Corrado
Journal Article
United States
Catheter Cardiovasc Interv. 2010 Nov 1;76(5):757-66. doi: 10.1002/ccd.22602.
PY - 2010
SN - 1522-1946
SP - 757-66
ST - Postprocedural management of patients after transcatheter aortic valve
implantation procedure with self-expanding bioprosthesis
TI - Postprocedural management of patients after transcatheter aortic valve
implantation procedure with self-expanding bioprosthesis
VL - 76
ID - 2633
ER -
TY - JOUR
AB - AIM OF THE STUDY: To study plasma concentrations of interleukin-6 (IL-6),
high-sensitivity C-reactive protein (hs-CRP) and S-100B during intensive care after
out-of-hospital cardiac arrest from ventricular fibrillation (OHCA-VF), and their
associations with the duration of ischemia, organ dysfunction and long-term
neurological outcome. MATERIALS AND METHODS: A 12-month prospective observational
multicentre study was conducted in 21 Finnish intensive care units in 2011. IL-6,
hs-CRP and S-100B were measured at 0-6 h, 24 h, 48 h and 96 h after ICU admission.
Associations with the time to return of spontaneous circulation (ROSC), sequential
organ failure assessment (SOFA) scores divided into tertiles and 12-month cerebral
performance category (CPC) were tested. RESULTS: Of 186 OHCA-VF patients included
in the study, 110 (59.1%) patients survived with good neurological outcome (CPC 1-
2) 12 months after cardiac arrest. Admission plasma concentrations of IL-6 but not
hs-CRP were higher with prolonged time to ROSC (p<0.001, 0.203, respectively), in
patients with subsequent higher SOFA scores (p<0.001, 0.069) and poor long-term
neurological outcome (CPC 3-5) (p<0.001, 0.315). S-100B concentrations over time
were higher in patients with CPC of 3-5 (p<0.001). The area under the curve for
prediction of poor 12-month outcome for admission levels was 0.711 IL-6, 0.663 for
S-100B and 0.534 for hs-CRP. With multivariate logistic regression analysis only
admission IL-6 (p=0.046, OR 1.006, 95% CI 1.000-1.011/ng/L) was an independent
predictor of poor neurological outcome. CONCLUSION: Admission high IL-6, but not
hs-CRP or S-100B, is associated with extra-cerebral organ dysfunction and along
with age and time to ROSC are independent predictors for 12-month poor neurologic
outcome (CPC 3-5).
AD - Intensive Care Units, Department of Anaesthesiology, Intensive Care and Pain
Medicine, Helsinki University Hospital, Helsinki, Finland. Electronic address:
jukka.vaahersalo@hus.fi.
Intensive Care Units, Department of Anaesthesiology, Intensive Care and Pain
Medicine, Helsinki University Hospital, Helsinki, Finland.
Department of Clinical Chemistry, School Of Medicine, University of Eastern Finland
and Eastern Finland Laboratory Centre, Kuopio, Finland.
Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Division of Medicine, Akershus University Hospital, Lørenskog, Norway and Institute
for Clinical Medicine, University of Oslo, Oslo, Norway.
Department of Anaesthesiology, South-Carelia Hospital, Lappeenranta, Finland.
Department of Neurology, Helsinki University Hospital, Helsinki, Finland.
Division of Intensive Care Medicine, Kuopio University Hospital, Kuopio, Finland.
AN - 25238742
AU - Vaahersalo, J.
AU - Skrifvars, M. B.
AU - Pulkki, K.
AU - Stridsberg, M.
AU - Røsjø, H.
AU - Hovilehto, S.
AU - Tiainen, M.
AU - Varpula, T.
AU - Pettilä, V.
AU - Ruokonen, E.
DA - Nov
DP - NLM
ET - 2014/09/23
IS - 11
J2 - Resuscitation
KW - Aged
Biomarkers/blood
Cardiopulmonary Resuscitation/*adverse effects/methods/mortality
Female
Finland
Hospital Mortality
Humans
Intensive Care Units
Interleukin-6/*blood
Logistic Models
Male
Middle Aged
Multiple Organ Failure/blood/mortality
Nervous System Diseases/epidemiology/*etiology/physiopathology
Out-of-Hospital Cardiac Arrest/*blood/mortality/therapy
*Patient Admission
Prognosis
Prospective Studies
Risk Assessment
S100 Proteins/analysis
Survival Analysis
Time Factors
Treatment Outcome
Ventricular Fibrillation/*blood/mortality/therapy
Cardiac arrest
High-sensitive C-reactive protein
Inflammation
Interleukin-6
Long-term neurological outcome
S-100b
LA - eng
N1 - 1873-1570
Vaahersalo, Jukka
Skrifvars, Markus B
Pulkki, Kari
Stridsberg, Mats
Røsjø, Helge
Hovilehto, Seppo
Tiainen, Marjaana
Varpula, Tero
Pettilä, Ville
Ruokonen, Esko
FINNRESUSCI Laboratory Study Group
Journal Article
Multicenter Study
Observational Study
Ireland
Resuscitation. 2014 Nov;85(11):1573-9. doi: 10.1016/j.resuscitation.2014.08.036.
Epub 2014 Sep 17.
PY - 2014
SN - 0300-9572
SP - 1573-9
ST - Admission interleukin-6 is associated with post resuscitation organ
dysfunction and predicts long-term neurological outcome after out-of-hospital
T2 - Resuscitation
TI - Admission interleukin-6 is associated with post resuscitation organ
dysfunction and predicts long-term neurological outcome after out-of-hospital
VL - 85
ID - 3002
ER -
TY - JOUR
AB - A 10-year-old girl presented with sudden onset recurrent ventricular
tachycardia and symmetrical distal peripheral gangrene. She also had pulmonary
thromboembolism and cerebral sinus venous thrombosis. Investigations revealed
anemia, hemolysis, hypocomplementemia, and elevated IgM anti-beta2 glycoprotein
antibody levels. Electrocardiogram and echocardiogram suggested features of a rare
cardiac anomaly, which was confirmed at autopsy.
AD - Departments of Pediatrics, *Histopathology and #Cardiology, PGIMER,
Chandigarh, India. Correspondence to: Dr Pankaj C Vaidya, Associate Professor,
Department of Pediatrics, Advanced Pediatrics Centre (APC), Postgraduate Institute
of Medical Education and Research (PGIMER), Chandigarh 160 012, India.
dr_pcv@yahoo.com.
AN - 27484444
AU - Vaiphei, K.
AU - Vaidya, P. C.
AU - Vignesh, P.
AU - Barwad, P.
AU - Gupta, A.
DA - Sep 8
DO - 10.1007/s13312-016-0937-6
DP - NLM
ET - 2016/10/25
IS - 9
J2 - Indian pediatrics
KW - Antibodies, Antiphospholipid
*Arrhythmogenic Right Ventricular Dysplasia
Child
Fatal Outcome
Female
Foot/pathology
*Gangrene
Hand/pathology
Humans
Pulmonary Embolism
*Tachycardia, Ventricular
LA - eng
N1 - 0974-7559
Vaiphei, Kim
Vaidya, Pankaj C
Vignesh, Pandiarajan
Barwad, Parag
Gupta, Anju
Case Reports
Journal Article
India
Indian Pediatr. 2016 Sep 8;53(9):815-821. doi: 10.1007/s13312-016-0937-6. Epub 2016
Jul 1.
PY - 2016
SN - 0019-6061
SP - 815-821
ST - Recurrent Ventricular Tachycardia and Peripheral Gangrene in a Young Child
T2 - Indian Pediatr
TI - Recurrent Ventricular Tachycardia and Peripheral Gangrene in a Young Child
VL - 53
ID - 2962
ER -
TY - JOUR
AB - Carotid sinus massage for diagnosis and termination of supraventricular
tachycardia (SVT) is still a widely used vagal manoeuvre in the A&E department.
However, itsefficacy is limited (termination of the SVT in approximately 20%) and
carotid sinus massage may be complicated by (potentially devastating) neurologic
complications in 0.2-1% of the patients. There are safer interventions without
neurologic complications, such as the modified Valsalva manoeuvre (efficacy 43%)
and intravenous administration of adenosine (efficacy 75%). Monitor observation of
the heart rhythm is required, both for vagal manoeuvres and for adenosine
administration, because of the possibility of ventricular tachycardia or
ventricular fibrillation induction (incidence 0.08%). Carotid sinus massage remains
an important diagnostic method in patients with unexplained syncope in whom, based
on the clinical history, carotid sinus hypersensitivity is suspected. It should be
avoided in patients with previous TIA or stroke within the past 3 months, or those
with carotid bruits, except if carotid Doppler studies have excluded significant
stenosis (≥ 70%).
AD - AMC, afd. Cardiologie, Amsterdam.
AN - 28378703
AU - van den Brink, R. B.
AU - de Lange, F. J.
DP - NLM
ET - 2017/04/06
KW - *Carotid Sinus
Humans
Massage
Syncope
Tachycardia, Supraventricular/*diagnosis
*Valsalva Maneuver
LA - dut
N1 - 1876-8784
van den Brink, R B A
de Lange, F J
Journal Article
Netherlands
Ned Tijdschr Geneeskd. 2017;161:D1312.
OP - Carotismassage is geen onschuldige interventie.
PY - 2017
SN - 0028-2162
SP - D1312
ST - [Carotid sinus massage is not a benign intervention]
TI - [Carotid sinus massage is not a benign intervention]
VL - 161
ID - 2880
ER -
TY - JOUR
AB - A small number of points in the NHG practice guideline 'Atrial fibrillation'
have been reviewed; this has important consequences for general practice. The risk
of ischaemic CVA in patients with atrial fibrillation is determined using a new
risk score (CHA2DS2-VASc). The target value of the resting ventricular frequency
has been increased from a maximum of 90 to a maximum of 110 beats per minute. Oral
anticoagulants are indicated in almost all patients aged 65 years and older with
atrial fibrillation; the only group in whom antithrombotic medication is not
indicated is men under the age of 75 with no cardiovascular comorbidity.
Acetylsalicylic acid for the prevention of thrombo-embolism is only indicated if
oral anticoagulants are contra-indicated. The new oral anticoagulants (NOACs) have
very limited use in the prevention of a thrombo-embolism in general practice.
AD - *Namens de NHG-werkgroep Atriumfibrilleren, waarvan de leden aan het eind van
dit artikel worden vermeld.
AN - 24330799
AU - van den Donk, M.
AU - Opstelten, W.
DP - NLM
ET - 2013/12/18
IS - 38
KW - Age Factors
Aged
Comorbidity
General Practice/*standards
Humans
*Practice Patterns, Physicians'
Risk Factors
Societies, Medical
LA - dut
N1 - 1876-8784
van den Donk, Maureen
Opstelten, Wim
Dutch College of General Practioners (NHG)
Journal Article
Review
Netherlands
Ned Tijdschr Geneeskd. 2013;157(38):A6697.
OP - Belangrijke wijzigingen in de NHG-standaard 'Atriumfibrilleren': herziene
versie verschenen.
PY - 2013
SN - 0028-2162
SP - A6697
ST - [Important changes in the Dutch College of General Practitioners (NHG)
practice guideline 'Atrial fibrillation': revised practice guideline issued]
TI - [Important changes in the Dutch College of General Practitioners (NHG)
practice guideline 'Atrial fibrillation': revised practice guideline issued]
VL - 157
ID - 2706
ER -
TY - JOUR
AB - BACKGROUND PRKAG2 syndrome diagnosis is already well-defined as Wolff-
Parkinson-White syndrome (WPW), ventricular hypertrophy (VH) due to glycogen
accumulation, and conduction system disease (CSD). Because of its rarity, there is
a lack of literature focused on the treatment. The present study aimed to describe
appropriate strategies for the treatment of affected family members with PRKAG2
syndrome with a long follow-up period. CASE REPORT We studied 60 selected
individuals from 84 family members (32 males, 53.3%) (mean age 27±16 years).
Patients with WPW and/or VH were placed in a group of 18 individuals, in which 11
(61.1%) had VH and WPW, 6 (33.3%) had isolated WPW, and 1 (5.6%) had isolated VH.
Palpitations occurred in 16 patients (88.9%), chest pain in 11 (61.1%), dizziness
in 13 (72.2%), syncope in 15 (83.3%), and dyspnea in 13 (72%). Sudden cardiac death
(SCD) occurred in 2 (11.1%), and 2 patients with cardiac arrest (CA) had asystole
and pre-excited atrial flutter-fibrillation (AFL and AF) as the documented
mechanism. Transient ischemic attack (TIA) and learning/language disabilities with
delayed development were observed. Genetic analysis identified a new missense
pathogenic variant (p.K290I) in the PRKAG2 gene. Cardiac histopathology
demonstrated the predominance of vacuoles containing glycogen derivative and
fibrosis. The treatment was based on hypertension and diabetes mellitus (DM)
control, antiarrhythmic drugs (AD), anticoagulation, and radiofrequency catheter
ablation (RCA). Six patients (33.3%) underwent pacemaker implantation (PM).
CONCLUSIONS The present study describes the clinical treatment for a rare cardiac
syndrome caused by a PRKAG2 mutation.
AD - Department of Postgraduate, Bahiana School of Medicine and Public Health,
Salvador, BA, Brazil.
Cardiovascular Genetics Center, IDIBGI, Girona, Spain.
Department of Medical Sciences, School of Medicine, University of Girona, Girona,
Spain.
Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares
(CIBERCV), Madrid, Spain.
Department of Anatomo Pathology, Dante Pazzanese of Cardiology Institute, São
Paulo, SP, Brazil.
Department of Anatomo Pathology, Clinic Hospital, Salvador, BA, Brazil.
Department of Cardiac Genetics Clinical Unit, Hospital Universitari Josep Trueta,
Hospital Santa Caterina, Girona, Spain.
AN - 28690312
AU - van der Steld, L. P.
AU - Campuzano, O.
AU - Pérez-Serra, A.
AU - Moura de Barros Zamorano, M.
AU - Sousa Matos, S.
AU - Brugada, R.
C2 - PMC5518846 of interest All participants provided written informed consent.
This study was approved by the São Rafael Hospital Institutional Review Board
(protocol no.16–12), as well as the Bahiana School of Medicine Institutional Review
Board (protocol no. 165.803). All authors have read the manuscript and agreed with
the results presented herein.
DA - Jul 10
DO - 10.12659/ajcr.904613
DP - NLM
ET - 2017/07/12
J2 - The American journal of case reports
KW - AMP-Activated Protein Kinases/genetics
Abortion, Spontaneous/etiology
Adult
Autistic Disorder/etiology
Brazil
Child, Preschool
Developmental Disabilities/etiology
Dizziness/etiology
Dyspnea/etiology
Female
Humans
Hypertrophy, Left Ventricular/*etiology/pathology
Hypertrophy, Right Ventricular/*etiology/pathology
Language Development Disorders/etiology
Male
Mutation, Missense
*Pedigree
Syncope/etiology
Wolff-Parkinson-White Syndrome/*genetics
LA - eng
N1 - 1941-5923
van der Steld, Lenises de Paula
Campuzano, Oscar
Pérez-Serra, Alexandra
Moura de Barros Zamorano, Mabel
Sousa Matos, Selma
Brugada, Ramon
Journal Article
Am J Case Rep. 2017 Jul 10;18:766-776. doi: 10.12659/ajcr.904613.
PY - 2017
SN - 1941-5923
SP - 766-776
ST - Wolff-Parkinson-White Syndrome with Ventricular Hypertrophy in a Brazilian
Family
T2 - Am J Case Rep
TI - Wolff-Parkinson-White Syndrome with Ventricular Hypertrophy in a Brazilian
Family
VL - 18
ID - 2337
ER -
TY - JOUR
AB - This case describes the occurrence of a tachycardia occurring early after a
subarachnoid haemorrhage.
AD - Department of Cardiology, Thoraxcenter, University Medical Center Groningen,
University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
i.c.van.gelder@thorax.umcg.nl
AN - 18199573
AU - Van Gelder, I. C.
AU - Boriani, G.
AU - Ernst, S.
AU - Heidbuchel, H.
AU - Zaza, A.
AU - Mäkijärvi, M.
AU - Gorenek, B.
AU - Lundquist, C. B.
DA - Jan
DP - NLM
ET - 2008/01/18
IS - 1
KW - Aged
Electric Countershock/*methods
Electrocardiography
Female
Humans
Stroke/*complications/etiology
Subarachnoid Hemorrhage/complications
Tachycardia, Ventricular/*etiology/physiopathology/*therapy
LA - eng
N1 - 1532-2092
Van Gelder, Isabelle C
EHRA Education Committee
Boriani, Giuseppe
Ernst, Sabine
Heidbuchel, Hein
Zaza, Antonio
Mäkijärvi, Markku
Gorenek, Bulent
Lundquist, Carina Blomström
Case Reports
Journal Article
England
Europace. 2008 Jan;10(1):77-8; 124. doi: 10.1093/europace/eum281.
PY - 2008
SN - 1099-5129
SP - 77-8; 124
ST - Case of polymorphic ventricular tachycardia after stroke necessitating
defibrillation
T2 - Europace
TI - Case of polymorphic ventricular tachycardia after stroke necessitating
defibrillation
VL - 10
ID - 2755
ER -
TY - JOUR
AB - A 59-year-old woman and a 41-year-old man were both brought to the Cardiac
Emergency Clinic with circulatory arrest on the basis ofpulseless electrical
activity. The first patient had had no prodromal symptoms and the second patient
had visited his general practitioner 2 weeks earlier because of pain in the head
and neck. In both patients, electrocardiography and echocardiography suggested
acute myocardial infarction. However, both patients proved to be suffering from a
subarachnoid haemorrhage (SAH) and both died. One-third ofthe patients with SAH are
comatose at presentation. Cardiac manifestations such as ECG-abnormalities, cardiac
arrhythmias, cardiopulmonary arrest, elevated troponin values, and signs of left
ventricular dysfunction are common. These findings can be misleading and may have
catastrophic consequences if anticoagulant therapy is initiated because of a
presumed myocardial infarction. Low-threshold CT-scanning of the brain is therefore
advised for patients who remain comatose after resuscitation for cardiac arrest in
the presence of an atypical anamnesis.
AD - Afd. Cardiologie, Gelre Ziekenhuizen, locatie Lukas, Apeldoorn.
m.van.gent@antonius.net
AN - 18326415
AU - van Gent, M. W.
AU - Kuiper, M. A.
AU - Manschot, T.
AU - Jerzewsky, A.
AU - Rommes, J. H.
AU - Spronk, P. E.
DA - Feb 9
DP - NLM
ET - 2008/03/11
IS - 6
KW - Adult
Arrhythmias, Cardiac/diagnosis/pathology
Echocardiography
Electrocardiography
*Emergency Service, Hospital
Fatal Outcome
Female
Humans
Male
Middle Aged
Myocardial Infarction/diagnosis/pathology
Subarachnoid Hemorrhage/*diagnosis/pathology
LA - dut
N1 - van Gent, M W F
Kuiper, M A
Manschot, Th
Jerzewsky, A
Rommes, J H
Spronk, P E
Case Reports
English Abstract
Journal Article
Netherlands
Ned Tijdschr Geneeskd. 2008 Feb 9;152(6):331-6.
OP - Subarachnoïdale bloeding met de klinische presentatie van een
circulatiestilstand bij acuut myocardinfarct.
PY - 2008
SN - 0028-2162 (Print)
0028-2162
SP - 331-6
ST - [Subarachnoid haemorrhage presenting clinically as circulatory arrest in
acute myocardial infarction]
TI - [Subarachnoid haemorrhage presenting clinically as circulatory arrest in
acute myocardial infarction]
VL - 152
ID - 2853
ER -
TY - JOUR
AB - The mechanisms underlying cardiac standstill in health and disease are
considered. Ventricular standstill results from failure of impulse formation or
transmission in the ventricles. In the healthy heart, idioventricular automaticity
is not brought into play and instead is suppressed by the sinus node by virtue of
its faster rate (overdrive suppression). However, should the sinus node activity be
suppressed or atrioventricular (AV) conduction blocked, overdrive suppression no
longer persists. For this reason, the ventricular pacemakers activate the
ventricles at a slow rate and under the regulatory activity of the sympathetic
system. In the diseased heart, the idioventricular pacemakers or the regulatory
mechanism can be altered structurally or functionally. This can be the result of
the disease, compensatory mechanisms or therapeutic interventions. Disease may
affect the idioventricular pacemakers directly or indirectly through anoxia, a
change in ionic environment or an alteration of sympathetic innervation.
Compensatory mechanisms may affect reflex actions, blood supply or heart rate. Drug
administration may alter autonomic balance, block the action of neuromediators on
their receptors or modify diastolic depolarization or its ability to attain the
threshold. Because of these different direct and indirect actions, a sudden
cessation of sinus node activity or sudden AV block may result in the diseased
heart in a prolonged and even fatal cardiac standstill, especially if the tolerance
to ischemia of other organs (notably the brain) is decreased.
AN - 3889112
AU - Vassalle, M.
DA - Jun
DO - 10.1016/s0735-1097(85)80525-8
DP - NLM
ET - 1985/06/01
IS - 6 Suppl
Animals
Autonomic Nervous System/physiopathology
Heart Arrest/etiology/*physiopathology
Heart Block/physiopathology
Heart Diseases/physiopathology
Humans
Sinoatrial Node/physiopathology
Vagus Nerve/physiopathology
Ventricular Function
LA - eng
N1 - Vassalle, M
Journal Article
Review
United States
J Am Coll Cardiol. 1985 Jun;5(6 Suppl):35B-42B. doi: 10.1016/s0735-1097(85)80525-8.
PY - 1985
SN - 0735-1097 (Print)
0735-1097
SP - 35b-42b
ST - On the mechanisms underlying cardiac standstill: factors determining success
or failure of escape pacemakers in the heart
TI - On the mechanisms underlying cardiac standstill: factors determining success
or failure of escape pacemakers in the heart
VL - 5
ID - 2815
ER -
TY - JOUR
AB - A 19-year-old African American man presented to a local emergency room with
atrial flutter, dysarthria, and left-sided hemiparesis. He was previously healthy
and a successful high school athlete. The patient decompensated and went into
cardiac arrest. Two-dimensional echocardiography revealed biventricular dilation,
severe systolic dysfunction, and a spongy myocardial appearance. Postmortem
examination was diagnostic of biventricular noncompaction. Such a fulminant
presentation of isolated ventricular noncompaction in a previously healthy and
physically fit individual has not yet been described.
AD - St Vincent Hospitals and Health Services, Indianapolis, Indiana, USA.
rosh_04@hotmail.com
AN - 19647400
AU - Vatthyam, R. K.
AU - Bates, J. R.
AU - Waller, B. F.
DA - Dec
DO - 10.1016/j.echo.2009.06.010
DP - NLM
ET - 2009/08/04
IS - 12
KW - Atrial Flutter/complications/*diagnostic imaging
Cardiomyopathy, Dilated/complications/*diagnostic imaging
Fatal Outcome
Humans
Isolated Noncompaction of the Ventricular Myocardium/complications/*diagnostic
imaging
Male
*Sports
Stroke/complications/*diagnostic imaging
Ultrasonography
Young Adult
LA - eng
N1 - 1097-6795
Vatthyam, Roshan K
Bates, John R
Waller, Bruce F
Case Reports
Journal Article
United States
J Am Soc Echocardiogr. 2009 Dec;22(12):1420.e1-3. doi: 10.1016/j.echo.2009.06.010.
Epub 2009 Jul 31.
PY - 2009
SN - 0894-7317
SP - 1420.e1-3
ST - Acute cardiac and neurologic decompensation in a high school athlete
TI - Acute cardiac and neurologic decompensation in a high school athlete
VL - 22
ID - 2756
ER -
TY - JOUR
AB - OBJECTIVE: Noninvasive blood pressure (BP) measurement often triggers a
transient rise in BP, known as an alerting reaction. However, the prevalence and
prognostic significance of the alerting reaction has never been assessed in the
general population. METHODS: We evaluated the association between the alerting
reaction and left ventricular mass by MRI and urinary albumin-to-creatinine ratio
in the Dallas Heart Study, a large population sample of 3069 individuals.
Participants were categorized into four groups based on levels of consecutive BP:
first, normal first BP and average third to fifth (avg3-5) BP of less than 140/90
mmHg (control group); second, high first BP of at least 140/90 mmHg and normal
(avg3-5) BP (alerting reaction group); third, normal first BP and high (avg3-5) BP;
and fourth, high first to fifth BP. Then, associations between BP categories with
incident cardiovascular outcomes (coronary heart disease, stroke, atrial
fibrillation, heart failure, and cardiovascular death) over a median follow-up
period of 9.4 years were assessed. RESULTS: The sample-weighted prevalence of
isolated hypertension during the first BP measurement was 9.6%. Presence of an
alerting reaction was independently associated with increased left ventricular
mass, urinary albumin-to-creatinine ratio, cardiovascular events after adjustment
for traditional cardiovascular risk factors, and baseline BP (adjusted hazard ratio
1.24, 95% confidence interval 1.07-1.43). CONCLUSION: Our study indicated that the
alerting reaction is independently associated with increased cardiovascular and
renal complications.
AD - aHypertension SectionbCardiology Division, University of Texas Southwestern
Medical Center, Dallas, TexascCedars-Sinai Heart Institute/ Hypertension Center,
Los Angeles, California, USA.
AN - 26485459
AU - Velasco, A.
AU - Ayers, C.
AU - Das, S. R.
AU - de Lemos, J. A.
AU - Khera, A.
AU - Victor, R. G.
AU - Kaplan, N. M.
AU - Vongpatanasin, W.
C2 - PMC5127693
C6 - NIHMS829856
DA - Feb
DO - 10.1097/hjh.0000000000000774
DP - NLM
ET - 2015/10/21
IS - 2
KW - Adult
Albuminuria/epidemiology
*Blood Pressure Determination
Creatinine/urine
Female
Heart Ventricles/*pathology
Humans
Hypertension/epidemiology/*physiopathology
Hypertrophy, Left Ventricular/epidemiology/pathology
Incidence
Male
Middle Aged
Prevalence
Prognosis
Renal Insufficiency/epidemiology/urine
Risk Factors
Stroke/epidemiology
LA - eng
N1 - 1473-5598
Velasco, Alejandro
Ayers, Colby
Das, Sandeep R
de Lemos, James A
Khera, Amit
Victor, Ronald G
Kaplan, Norman M
Vongpatanasin, Wanpen
UL1TR000124/TR/NCATS NIH HHS/United States
P30 DK079328/DK/NIDDK NIH HHS/United States
UL1TR001105/TR/NCATS NIH HHS/United States
Journal Article
J Hypertens. 2016 Feb;34(2):226-34. doi: 10.1097/HJH.0000000000000774.
PY - 2016
SN - 0263-6352 (Print)
0263-6352
SP - 226-34
ST - Target organ complications and prognostic significance of alerting reaction:
analysis from the Dallas Heart Study
T2 - J Hypertens
TI - Target organ complications and prognostic significance of alerting reaction:
analysis from the Dallas Heart Study
VL - 34
ID - 2883
ER -
TY - JOUR
AB - Anticoagulation is a treatment with significant and life threatening
complications requiring that the balance of risk and benefit be individually
assessed in each patient. The risks are greater in the elderly and those with
hypertension, falls and gastrointestinal disease. The use of anticoagulants is now
established in patients with symptomatic non-rheumatic atrial fibrillation,
especially older patients with hypertension, cardiac failure or a large left atrium
or left ventricular dysfunction. There is, however, no place for the routine use of
anticoagulants in acute stroke or as part of secondary prevention in patients in
sinus rhythm. There may be a place, though as yet the evidence would not support
this, for the limited use of anticoagulants in special situations such as cortical
venous thrombosis or carotid dissection.
AD - Department of Neurology, Central Sheffield University Hospitals NHS Trust,
UK.
AN - 11092099
AU - Venables, G. S.
DO - 10.1258/0007142001903157
DP - NLM
ET - 2000/11/25
IS - 2
J2 - British medical bulletin
KW - Anticoagulants/adverse effects/*therapeutic use
Humans
Risk Assessment
Sinus Thrombosis, Intracranial/drug therapy
LA - eng
N1 - Venables, G S
Journal Article
Review
England
Br Med Bull. 2000;56(2):501-9. doi: 10.1258/0007142001903157.
PY - 2000
SN - 0007-1420 (Print)
0007-1420
SP - 501-9
ST - Anticoagulants
T2 - Br Med Bull
TI - Anticoagulants
VL - 56
ID - 2425
ER -
TY - JOUR
AB - BACKGROUND: Evidence on new-onset atrial fibrillation in high-risk vascular
patients without heart failure is limited. New-onset atrial fibrillation was a
prespecified secondary objective of the Ongoing Telmisartan Alone and in
Combination With Ramipril Global Endpoint Trial (ONTARGET)/Telmisartan Randomized
AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease (TRANSCEND)
studies. METHODS: We studied 30 424 ONTARGET/TRANSCEND patients (mean age ± SD,
66.4 ± 7.0) with vascular disease or complicated diabetes who were in sinus rhythm
at entry. A copy of ECG was sent to central office every time new atrial
fibrillation was detected by investigators. RESULTS: During a median follow-up
period of 4.7 years, new atrial fibrillation occurred in 2092 patients (15.1 per
1000 patient-years). Risk of atrial fibrillation increased with age, SBP and pulse
pressure, left ventricular hypertrophy, BMI, serum creatinine and history of
hypertension, coronary artery disease and cerebrovascular disease (all P < 0.01).
After adjustment for BMI and other variables, atrial fibrillation risk increased
with hip circumference. History of hypertension was associated with a 34% higher
risk of new atrial fibrillation. New atrial fibrillation portended an increased
risk of congestive heart failure [hazard ratio 2.89, 95% confidence interval (CI)
2.45-3.40, P < 0.01] and cardiovascular death (hazard ratio 1.22, 95% CI 1.05-1.41,
P < 0.01). Risk of stroke was unaffected (hazard ratio 1.14, 95% CI 0.93-1.40),
whereas that of myocardial infarction was reduced (hazard ratio 0.64, 95% CI 0.50-
0.82). Patients with new atrial fibrillation were more likely to receive vitamin K
antagonists (P < 0.01), statins (P < 0.05) and β-blockers (P < 0.01) than those in
sinus rhythm. CONCLUSION: New atrial fibrillation is common in high-risk vascular
patients and is associated with several risk factors including history of
hypertension. Hip circumference was the strongest anthropometric predictor. Despite
extensive use of modern therapies, new atrial fibrillation carries a high risk of
congestive heart failure and death over a relatively short term.
AD - Department of Medicine, Hospital of Assisi, Assisi, Italy. verdec@tin.it
AN - 22495138
AU - Verdecchia, P.
AU - Dagenais, G.
AU - Healey, J.
AU - Gao, P.
AU - Dans, A. L.
AU - Chazova, I.
AU - Binbrek, A. S.
AU - Iacobellis, G.
AU - Ferreira, R.
AU - Holwerda, N.
AU - Karatzas, N.
AU - Keltai, M.
AU - Mancia, G.
AU - Sleight, P.
AU - Teo, K.
AU - Yusuf, S.
DA - May
DO - 10.1097/HJH.0b013e3283522a51
DP - NLM
ET - 2012/04/13
IS - 5
KW - Aged
Angiotensin II Type 1 Receptor Blockers/therapeutic use
Anthropometry
Atrial Fibrillation/*diagnosis
Benzimidazoles/*pharmacology
Benzoates/*pharmacology
Body Mass Index
Cardiovascular Diseases/complications/*diagnosis
Diabetes Complications/diagnosis
Double-Blind Method
Female
Humans
Hypertrophy, Left Ventricular/pathology
Male
Middle Aged
Placebos
Ramipril/*pharmacology
Risk
Risk Factors
Stroke/diagnosis
Telmisartan
LA - eng
N1 - 1473-5598
Verdecchia, Paolo
Dagenais, Gilles
Healey, Jeff
Gao, Peggy
Dans, Antonio L
Chazova, Irina
Binbrek, Azan S
Iacobellis, Gianluca
Ferreira, Rafael
Holwerda, Nicolaas
Karatzas, Nicholas
Keltai, Matyas
Mancia, Giuseppe
Sleight, Peter
Teo, Koon
Yusuf, Salim
Ongoing Telmisartan Alone and in Combination With Ramipril Global Endpoint
TrialTelmisartan Randomized AssessmeNt Study in ACE iNtolerant subjects with
cardiovascular Disease Investigators
Journal Article
England
J Hypertens. 2012 May;30(5):1004-14. doi: 10.1097/HJH.0b013e3283522a51.
PY - 2012
SN - 0263-6352
SP - 1004-14
ST - Blood pressure and other determinants of new-onset atrial fibrillation in
patients at high cardiovascular risk in the Ongoing Telmisartan Alone and in
Combination With Ramipril Global Endpoint Trial/Telmisartan Randomized AssessmeNt
Study in ACE iNtolerant subjects with cardiovascular Disease studies
T2 - J Hypertens
TI - Blood pressure and other determinants of new-onset atrial fibrillation in
patients at high cardiovascular risk in the Ongoing Telmisartan Alone and in
Combination With Ramipril Global Endpoint Trial/Telmisartan Randomized AssessmeNt
Study in ACE iNtolerant subjects with cardiovascular Disease studies
VL - 30
ID - 2487
ER -
TY - JOUR
AB - AIM: We tested the hypothesis that left ventricular hypertrophy (LVH)
interferes with the antithrombotic effects of dabigatran and warfarin in patients
with atrial fibrillation (AF). METHODS AND RESULTS: This is a post-hoc analysis of
the Randomized Evaluation of Long-term anticoagulation therapY (RE-LY) Study. We
defined LVH by electrocardiography (ECG) and included patients with AF on the ECG
tracing at entry. Hazard ratios (HR) for each dabigatran dose vs. warfarin were
calculated in relation to LVH. LVH was present in 2353 (22.7%) out of 10 372
patients. In patients without LVH, the rates of primary outcome were 1.59%/year
with warfarin, 1.60% with dabigatran 110 mg (HR vs. warfarin 1.01, 95% confidence
interval (CI) 0.75-1.36) and 1.08% with dabigatran 150 mg (HR vs. warfarin 0.68,
95% CI 0.49-0.95). In patients with LVH, the rates of primary outcome were
3.21%/year with warfarin, 1.69% with dabigatran 110 mg (HR vs. warfarin 0.52, 95%
CI 0.32-0.84) and 1.55% with 150 mg (HR vs. warfarin 0.48, 95% CI 0.29-0.78). The
interaction between LVH status and dabigatran 110 mg vs. warfarin was significant
for the primary outcome (P = 0.021) and stroke (P = 0.016). LVH was associated with
a higher event rate with warfarin, not with dabigatran. In the warfarin group, the
time in therapeutic range was significantly lower in the presence than in the
absence of LVH. CONCLUSIONS: LVH was associated with a lower antithrombotic
efficacy of warfarin, but not of dabigatran, in patients with AF. Consequently, the
relative benefit of the lower dose of dabigatran compared to warfarin was enhanced
in patients with LVH. The higher dose of dabigatran was superior to warfarin
regardless of LVH status. CLINICAL TRIAL REGISTRATION: http:www.clinicaltrials.gov.
Unique identifier: NCT00262600.
AD - Department of Medicine, Hospital of Assisi, Assisi, Italy.
Department of Medicine, University of Perugia, Perugia, Italy.
Department of Cardiology and Cardiovascular Pathophysiology, Hospital S.M. della
Misericordia, Perugia, Italy.
University of Birmingham Institute of Cardiovascular Sciences, City Hospital,
Birmingham, UK.
Boehringer Ingelheim GmbH & Co, Ingelheim am Rhein, Germany.
Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany.
Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.
Sidney Kimmel Medical College at Jefferson University, Philadelphia, PA, USA.
Medical College and Lankenau Medical Center, Wynnewood, PA, USA.
McMaster University, Hamilton, Ontario, Canada.
Department of Cardiology, Maggiore Hospital, Bologna, Italy.
AN - 28520924
AU - Verdecchia, P.
AU - Reboldi, G.
AU - Angeli, F.
AU - Mazzotta, G.
AU - Lip, G. Y. H.
AU - Brueckmann, M.
AU - Kleine, E.
AU - Wallentin, L.
AU - Yusuf, S.
C2 - PMC5834147
DA - Feb 1
DO - 10.1093/europace/eux022
DP - NLM
ET - 2017/05/19
IS - 2
KW - Aged
Aged, 80 and over
Antithrombins/*administration & dosage/adverse effects
Atrial Fibrillation/diagnosis/*drug therapy/physiopathology
Dabigatran/*administration & dosage/adverse effects
Electrocardiography
Female
Humans
Hypertrophy, Left Ventricular/diagnosis/*physiopathology
Male
Middle Aged
Risk Factors
Stroke/diagnosis/physiopathology/*prevention & control
Time Factors
Treatment Outcome
*Dabigatran
*Stroke
*Systemic embolism
*Warfarin
LA - eng
N1 - 1532-2092
Verdecchia, Paolo
Reboldi, Gianpaolo
Angeli, Fabio
Mazzotta, Giovanni
Lip, Gregory Y H
Brueckmann, Martina
Kleine, Eva
Wallentin, Lars
Yusuf, Salim
Connolly, Stuart J
Comparative Study
Journal Article
Europace. 2018 Feb 1;20(2):253-262. doi: 10.1093/europace/eux022.
PY - 2018
SN - 1099-5129 (Print)
1099-5129
SP - 253-262
ST - Dabigatran vs. warfarin in relation to the presence of left ventricular
hypertrophy in patients with atrial fibrillation- the Randomized Evaluation of
Long-term anticoagulation therapY (RE-LY) study
T2 - Europace
TI - Dabigatran vs. warfarin in relation to the presence of left ventricular
hypertrophy in patients with atrial fibrillation- the Randomized Evaluation of
Long-term anticoagulation therapY (RE-LY) study
VL - 20
ID - 2512
ER -
TY - JOUR
AB - It is unknown whether left ventricular hypertrophy (LVH) diagnosis by
electrocardiography improves risk stratification in patients with atrial
fibrillation (AF). We investigated the prognostic impact of LVH diagnosis by
electrocardiography in a large sample of anticoagulated patients with AF included
in the Randomized Evaluation of Long-Term Anticoagulant Therapy (RE-LY) Study. We
defined electrographic LVH (ECG-LVH) by strain pattern or Cornell voltage (R wave
in aVL plus S wave in V3) >2.0 mV (women) or >2.4 mV (men). LVH prevalence was
22.7%. During a median follow-up of 2.0 years, 303 patients developed a stroke, 778
died (497 from cardiovascular causes), and 140 developed a myocardial infarction.
LVH was associated with a greater risk of stroke (1.99% vs 1.32% per year, hazard
ratio [HR] 1.51, 95% confidence interval [CI] 1.18 to 1.93, p <0.001),
cardiovascular death (4.52% vs 1.80% per year, HR 2.56, 95% CI 2.14 to 3.06, p
<0.0001), all-cause death (6.03% vs 3.11% per year, HR 1.95, 95% CI 1.68 to 2.26, p
<0.0001), and myocardial infarction (1.11% vs 0.55% per year, HR 2.07, 95% CI 1.47
to 2.92, p <0.0001). In multivariate analysis, the prognostic value of LVH was
additive to CHA2DS2-VASc score and other covariates. The category-free net
reclassification index and integrated discrimination improvement increased
significantly after adding LVH to multivariate models. In conclusion, our study
demonstrates for the first time that ECG-LVH, a simple and easily accessible
prognostic indicator, improves risk stratification in anticoagulated patients with
AF.
AD - Department of Medicine, Hospital of Assisi, Assisi, Italy. Electronic
address: verdec@tin.it.
Department of Internal Medicine, University of Perugia, Perugia, Italy.
Department of Cardiology, Maggiore Hospital, Bologna, Italy.
Department of Cardiology and Cardiovascular Pathophysiology, University of Perugia,
Perugia, Italy.
Population Health Research Institute, Hamilton Health Sciences and McMaster
University, Hamilton, Ontario, Canada.
Uppsala Clinical Research Center and Department of Medical Sciences, Uppsala
University, Uppsala, Sweden.
Jefferson Medical College, Wynnewood, Pennsylvania; Atrial Fibrillation Research
and Education, Cardiovascular Research Foundation, New York, New York.
AN - 24359765
AU - Verdecchia, P.
AU - Reboldi, G.
AU - Mazzotta, G.
AU - Ambrosio, G.
AU - Yang, S.
AU - Pogue, J.
AU - Wallentin, L.
AU - Yusuf, S.
DA - Feb 15
DO - 10.1016/j.amjcard.2013.10.045
DP - NLM
ET - 2013/12/24
IS - 4
KW - Aged
Aged, 80 and over
Atrial Fibrillation/*drug therapy/mortality
Female
Humans
Hypertrophy, Left Ventricular/*diagnosis/mortality
Male
Middle Aged
Prevalence
Prognosis
Risk Assessment
Stroke/epidemiology
Survival Analysis
LA - eng
N1 - 1879-1913
Verdecchia, Paolo
Reboldi, Gianpaolo
Mazzotta, Giovanni
Ambrosio, Giuseppe
Yang, Sean
Pogue, Janice
Wallentin, Lars
Connolly, Stuart J
Yusuf, Salim
RE-LY Study Investigators
Journal Article
United States
Am J Cardiol. 2014 Feb 15;113(4):669-75. doi: 10.1016/j.amjcard.2013.10.045. Epub
2013 Nov 23.
PY - 2014
SN - 0002-9149
SP - 669-75
ST - Prognostic usefulness of left ventricular hypertrophy by electrocardiography
in patients with atrial fibrillation (from the Randomized Evaluation of Long-Term
Anticoagulant Therapy Study)
T2 - Am J Cardiol
TI - Prognostic usefulness of left ventricular hypertrophy by electrocardiography
in patients with atrial fibrillation (from the Randomized Evaluation of Long-Term
Anticoagulant Therapy Study)
VL - 113
ID - 2708
ER -
TY - JOUR
AB - BACKGROUND: Tiotropium has been associated with an increased risk of
mortality and/or cardiovascular events. Recent data from RCTs suggests tiotropium
Handihaler to be safe, but its safety has not yet been fully investigated under
real-life circumstances. METHODS: We conducted 2 nested case-control studies in a
COPD cohort from the Dutch IPCI database. In the first case-control study, cases
had a cardiovascular or cerebrovascular endpoint (CCVE): stroke and transient
ischemic attack (TIA), myocardial infarction, heart failure and/or ventricular
arrhythmia. In the second, cases were all patients who died. Cases were matched to
controls on age, sex and index date. Conditional logistic regression analysis was
used to calculate adjusted odds ratios (OR(adj)) with 95% confidence intervals (CI)
for tiotropium vs. long-acting beta-agonists (LABA). RESULTS: Within a cohort of
6788 COPD patients, 784 CCVE's and 1032 deaths were reported. Compared to current
LABA use, use of tiotropium Handihaler was neither associated with an increased
risk of a CCVE (OR(adj) 0.89, 95% 0.55-1.44) nor with an increased risk of death
(OR(adj) 0.79, 95% CI 0.49-1.28). CONCLUSIONS: In real life, use of tiotropium
Handihaler in COPD patients is not associated with an increased risk of a CCVE or
mortality compared to LABA.
AD - Department of Medical Informatics, Erasmus MC, Rotterdam, The Netherlands.
k.verhamme@erasmusmc.nl
AN - 22051450
AU - Verhamme, K. M.
AU - Afonso, A. S.
AU - van Noord, C.
AU - Haag, M. D.
AU - Koudstaal, P. J.
AU - Brusselle, G. G.
AU - Sturkenboom, M. C.
DA - Feb
DO - 10.1016/j.pupt.2011.10.004
DP - NLM
ET - 2011/11/05
IS - 1
J2 - Pulmonary pharmacology & therapeutics
KW - Adrenergic beta-Agonists/adverse effects
Adult
Age Factors
Aged
Arrhythmias, Cardiac/chemically induced/epidemiology/mortality
Bronchodilator Agents/administration & dosage/*adverse effects/*therapeutic use
Cardiovascular Diseases/*chemically induced/mortality
Cerebrovascular Disorders/*chemically induced/mortality
Cohort Studies
Databases, Factual
Endpoint Determination
Female
Heart Failure/chemically induced/epidemiology/mortality
Humans
Ischemic Attack, Transient/chemically induced/epidemiology/mortality
Logistic Models
Male
Middle Aged
Myocardial Infarction/chemically induced/epidemiology/mortality
*Nebulizers and Vaporizers
Odds Ratio
Pulmonary Disease, Chronic Obstructive/*drug therapy/mortality
Scopolamine Derivatives/administration & dosage/*adverse effects/*therapeutic use
Sex Factors
Stroke/chemically induced/epidemiology/mortality
Tiotropium Bromide
LA - eng
N1 - 1522-9629
Verhamme, K M C
Afonso, A S M
van Noord, C
Haag, M D
Koudstaal, P J
Brusselle, G G O
Sturkenboom, M C J M
Journal Article
England
Pulm Pharmacol Ther. 2012 Feb;25(1):19-26. doi: 10.1016/j.pupt.2011.10.004. Epub
2011 Oct 21.
PY - 2012
SN - 1094-5539
SP - 19-26
ST - Tiotropium Handihaler and the risk of cardio- or cerebrovascular events and
mortality in patients with COPD
T2 - Pulm Pharmacol Ther
TI - Tiotropium Handihaler and the risk of cardio- or cerebrovascular events and
mortality in patients with COPD
VL - 25
ID - 2378
ER -
TY - JOUR
AB - BACKGROUND: Fabry disease (FD) is a genetic disorder caused by a deficiency
in the enzyme alpha-galactosidase A, leading to an accumulation of
glycosphingolipids in tissues across the body. Cardiac disease is the leading cause
of morbidity and mortality. Advanced disease, characterised by extensive left
ventricular hypertrophy, ventricular dysfunction and fibrosis, is known to be
associated with an increase in arrhythmia. Data identifying risk factors for
arrhythmia are limited, and no Fabry-specific risk stratification tool is available
to select those who may benefit from initiation of medical or device therapy
(implantable cardiac defibrillators). Current monitoring strategies have a limited
diagnostic yield, and implantable loop recorders (ILRs) have the potential to
change treatment and clinical outcomes. AIM: The aim of this study is to determine
whether ILRs can (1) improve arrhythmia detection in FD and (2) identify risk
predictors of arrhythmia. METHODS: A prospective, 5-year, open-label,
international, multi-centre randomised controlled trial of a minimum of 164
participants with genetically or enzymatically confirmed FD (or both) who have
evidence of cardiac disease will be recruited from five centres: Queen Elizabeth
Hospital, Birmingham, UK; Salford Royal Hospital, Salford, UK; Royal Free Hospital,
London, UK; Addenbrookes Hospital, Cambridge, UK; and Westmead Hospital, Sydney,
Australia. Participants will be block-randomised (1:1) to two study arms for
cardiac monitoring (i) control arm: standard of care with annual 24 h or 5-day
Holter monitor or (ii) treatment arm: continuous cardiac monitoring with ILR
implantation plus standard of care. Participants will undergo multiple
investigations-blood/urine biomarkers, 12-lead and advanced electrocardiogram (ECG)
recording, echocardiography and cardiovascular magnetic resonance (CMR) imaging-at
baseline and 6-12 monthly follow-up visits. The primary endpoint is identification
of arrhythmia requiring initiation or alteration in therapy. Secondary outcome
measures include characterising the risk factors associated with arrhythmia and
outcome data in the form of imaging, ECG and blood biomarkers. DISCUSSION: This is
the first study evaluating arrhythmia burden and the use of ILR across the spectrum
of risk profiles in Fabry cardiomyopathy. This will enable detailed
characterisation of arrhythmic risk predictors in FD and ultimately support
formulation of Fabry-specific guidance in this high-risk population. TRIAL
REGISTRATION: ClinicalTrials.gov ( NCT03305250 ). Registered on 9 October 2017.
AD - Department of Cardiology, Queen Elizabeth Hospital Birmingham, Mindlesohn
Way, Birmingham, B15 2TH, UK. ravi.vijapurapu@nhs.net.
Institute of Cardiovascular Sciences, University of Birmingham, Edgbaston,
Birmingham, B15 2TT, UK. ravi.vijapurapu@nhs.net.
Department of Endocrinology, Queen Elizabeth Hospital Birmingham, Mindlesohn Way,
Birmingham, B15 2TH, UK. ravi.vijapurapu@nhs.net.
Sydney Medical School, University of Sydney, Sydney, 2006, NSW, Australia.
Cardiology Department, Royal North Shore Hospital, Reserve Road, St. Leonards, NSW,
2065, Australia.
Lysosomal Storage Disorder Unit, Royal London NHS Foundation Trust, University
College London, Pond Street, London, NW3 2QG, UK.
Department of Cardiology, Salford Royal Hospital, Stott Lane, Salford, M6 8HD, UK.
Mark Holland Metabolic Unit, Salford Royal Hospital, Stott Lane, Salford, M6 8HD,
UK.
Department of Medicine, Addenbrooke's Hospital, Hill Road, Cambridge, CB2 0QQ, UK.
Department of Cardiology, Addenbrookes Hospital, Hill Road, Cambridge, CB2 0QQ, UK.
Department of Genetics, Westmead Hospital, Hawkesbury Road, Westmead, NSW, 2145,
Australia.
Department of Cardiology, Queen Elizabeth Hospital Birmingham, Mindlesohn Way,
Birmingham, B15 2TH, UK.
Institute of Cardiovascular Sciences, University of Birmingham, Edgbaston,
Birmingham, B15 2TT, UK.
Aston Medical Research Institute, Aston Medical School, Birmingham, B4 7ET, UK.
Barts Heart Centre, Barts Health NHS Trust, 16-18 Westmoreland Street, London, W1G
8PH, UK.
Department of Endocrinology, Queen Elizabeth Hospital Birmingham, Mindlesohn Way,
Birmingham, B15 2TH, UK.
Institute of Metabolism and System Research, University of Birmingham, Edgbaston,
Birmingham, B15 2TT, UK.
AN - 31151481
AU - Vijapurapu, R.
AU - Kozor, R.
AU - Hughes, D. A.
AU - Woolfson, P.
AU - Jovanovic, A.
AU - Deegan, P.
AU - Rusk, R.
AU - Figtree, G. A.
AU - Tchan, M.
AU - Whalley, D.
AU - Kotecha, D.
AU - Leyva, F.
AU - Moon, J.
AU - Geberhiwot, T.
AU - Steeds, R. P.
C2 - PMC6544923
DA - May 31
DO - 10.1186/s13063-019-3425-1
DP - NLM
ET - 2019/06/04
IS - 1
J2 - Trials
KW - Arrhythmias, Cardiac/*diagnosis
Cost of Illness
Fabry Disease/*complications
Humans
Prospective Studies
Sample Size
Standard of Care
Stroke/*etiology
Arrhythmia
Cardiomyopathy
Fabry
ILR
Sanofi-Genzyme and Amicus. The other authors declare that they have no competing
interests.
LA - eng
N1 - 1745-6215
Vijapurapu, Ravi
Orcid: 0000-0002-2472-5538
Kozor, Rebecca
Hughes, Derralynn A
Woolfson, Peter
Jovanovic, Ana
Deegan, Patrick
Rusk, Rosemary
Figtree, Gemma A
Tchan, Michel
Whalley, David
Kotecha, Dipak
Leyva, Francisco
Moon, James
Geberhiwot, Tarekegn
Steeds, Richard P
WT_/Wellcome Trust/United Kingdom
CDF-2015-08-074/DH_/Department of Health/United Kingdom
GZ-2017-11698/Genzyme/
IIR-GBR-001662/Shire/
Comparative Study
Journal Article
Multicenter Study
Trials. 2019 May 31;20(1):314. doi: 10.1186/s13063-019-3425-1.
PY - 2019
SN - 1745-6215
SP - 314
ST - A randomised controlled trial evaluating arrhythmia burden, risk of sudden
cardiac death and stroke in patients with Fabry disease: the role of implantable
loop recorders (RaILRoAD) compared with current standard practice
T2 - Trials
TI - A randomised controlled trial evaluating arrhythmia burden, risk of sudden
cardiac death and stroke in patients with Fabry disease: the role of implantable
loop recorders (RaILRoAD) compared with current standard practice
VL - 20
ID - 2299
ER -
TY - JOUR
AB - Technical factors in mitral valve surgery (MVS) which may influence
neurological complications, trauma to the left atrium and formation of atrial mural
thrombi have not previously been described in detail. We have reviewed the records
of 146 patients (pts) undergoing MVS through the superior approach between January
1974 and May 1981. The series consisted of 97 females and 49 males with a mean age
of 57 +/- 18 years. All but 4 pts were in New York Heart Association functional
class III or IV. Twenty-five pts underwent open mitral commissurotomy, 116 had
valve replacement and 5 had annuloplasty. Concomitant procedures were coronary
bypass in 47, aortic valve replacement in 18 and resection of left ventricular
aneurysm in 3. Left atrial thrombi were removed in 21 pts. Thirteen pts (9%) died
postoperatively. The causes of death were left ventricular failure in 7, arrhythmia
in 4 and atrio-ventricular disruption in 2. Two of these pts also had cerebral
dysfunction. Autopsy examination in 8 pts failed to reveal formation of fresh left
atrial septal or posterior mural thrombus. Postoperative complications included
transient neurologic injury presumed to be due to air embolus in 3 and
postoperative bleeding from atrial suture line in one. The mean follow-up for the
survivors has been 30 months. There have been 16 (12%) late deaths from 1 to 72
months (mean 15). Autopsy examination of 4 pts and surgical exploration in one
other pt which failed to reveal organized left atrial mural thrombus. Only one late
death was related to prosthetic thrombosis. This occurred following cessation of
anticoagulations.(ABSTRACT TRUNCATED AT 250 WORDS)
AN - 4030873
AU - Vijayanagar, R.
AU - Bognolo, D. A.
AU - Eckstein, P. F.
AU - Jeffery, D. L.
AU - Harrison, E.
AU - Natarajan, P.
AU - Willard, E.
AU - Musunuru, R.
DA - Sep-Oct
DP - NLM
ET - 1985/09/01
IS - 5
J2 - The Journal of cardiovascular surgery
KW - Adult
Aged
Coronary Disease/etiology
Female
Heart Valve Diseases/complications/*surgery
Humans
Male
Middle Aged
*Mitral Valve
LA - eng
N1 - Vijayanagar, R
Bognolo, D A
Eckstein, P F
Jeffery, D L
Harrison, E
Natarajan, P
Willard, E
Musunuru, R
Journal Article
Italy
J Cardiovasc Surg (Torino). 1985 Sep-Oct;26(5):426-32.
PY - 1985
SN - 0021-9509 (Print)
0021-9509
SP - 426-32
ST - Advantages of superior approach for mitral valve surgery
T2 - J Cardiovasc Surg (Torino)
TI - Advantages of superior approach for mitral valve surgery
VL - 26
ID - 2885
ER -
TY - JOUR
AB - Reduction of the arrhythmia was obtained in 1 to 5 days, spontaneously (2
cases) of after oral amiodarone (500 to 2000 mg/m2/24 hr) (5 cases) or intravenous
flecainide or propafenone in the two most critically ill patients. With the
exception of 1 patient who was successfully treated with propranolol for 1 year,
amiodarone was prescribed in all cases for 7 to 36 months after reversion to sinus
rhythm: 5 children have been taken off treatment and seem to be completely cured 4
to 9 years after withdrawal; the other 3 patients have not had recurrences but have
only been treated for 6 to 15 months. One of them has neurological sequellae from a
cerebral embolism originating from an atrial thrombus. These results show that
incessant ventricular tachycardia in infancy is a serious condition but amenable to
medical treatment with high dose amiodarone or, when poorly tolerated, intravenous
Class 1c antiarrhythmics for reduction of the arrhythmia, and amiodarone at
adequate doses for 2 years to prevent recurrence. With the exception of the rare
arrhythmogenic right ventricular dysplasia, the long term prognosis would seem to
be excellent and, in general, there would seem to be little need for surgery.
AD - Service de cardiologie pédiatrique du hôpital Necker-Enfants Malades, Paris.
AN - 2114081
AU - Villain, E.
AU - Bonnet, D.
AU - Kachaner, J.
AU - Le Bidois, J.
AU - Cohen, L.
AU - Piéchaud, J. F.
AU - Sidi, D.
DA - May
DP - NLM
ET - 1990/05/01
IS - 5
Cardiomyopathies/complications
Child, Preschool
Electrocardiography
Female
Flecainide/therapeutic use
Follow-Up Studies
Heart Neoplasms/complications
Humans
Infant
Male
Prognosis
Tachycardia/complications/diagnosis/drug therapy/*etiology
LA - fre
N1 - Villain, E
Bonnet, D
Kachaner, J
Le Bidois, J
Cohen, L
Piéchaud, J F
Sidi, D
Case Reports
English Abstract
Journal Article
Review
France
Arch Mal Coeur Vaiss. 1990 May;83(5):665-71.
OP - Tachycardies ventriculaires incessantes idiopathiques du nourrisson.
PY - 1990
SN - 0003-9683 (Print)
0003-9683
SP - 665-71
ST - [Incessant idiopathic ventricular tachycardia in infants]
TI - [Incessant idiopathic ventricular tachycardia in infants]
VL - 83
ID - 2717
ER -
TY - JOUR
AB - A 36-year-old white patient is described. He received treatment for
hypertension and showed slightly increased excretion of 17-OHCS- and 17-
ketosteroids but no increase in values for 3-methoxy-4-hydroxymandelic acid in the
urine. He was admitted to hospital for a myocardial infarction, which was found to
be situated in the anterior wall. During his stay in hospital a sudden increase in
blood pressure occurred, together with a typical attach of perspiration, loss of
consciousness, and ventricular fibrillation. The assay by 3-methoxy-4-
hydroxymandelic acid now showed markedly increased amounts. A phaeochromocytoma was
thought to be the most probably diagnosis, but now withstanding therapy the patient
died from cerebral lesions. At necropsy a recent anteroseptal myocardial infarction
and some minor lesions were found but no tumour and notably no phaechromocytoma,
neither in the adrenals nor elsewhere. Using Dobbie's morphometric technique, as
described by Munro Neville (1969), changes in the adrenals were demonstrated, which
were considered to represent primary adrenal medullary hyperplasia. Criteria for
the diagnosis of this syndrome are discussed. Until now it had been presumed to be
present in a number of cases but never convincingly demonstrated.
AN - 1127122
AU - Visser, J. W.
AU - Axt, R.
C2 - PMC475694
DA - Apr
DO - 10.1136/jcp.28.4.298
DP - NLM
ET - 1975/04/01
IS - 4
J2 - Journal of clinical pathology
KW - Adrenal Cortex/pathology
Adrenal Gland Neoplasms/diagnosis
Adrenal Glands/pathology
Adrenal Medulla/*pathology
Adult
Autopsy
Brain Diseases/complications
Humans
Hyperplasia
Male
Mandelic Acids/analogs & derivatives/urine
Organ Size
Pheochromocytoma/diagnosis
LA - eng
N1 - 1472-4146
Visser, J W
Axt, R
Journal Article
J Clin Pathol. 1975 Apr;28(4):298-304. doi: 10.1136/jcp.28.4.298.
PY - 1975
SN - 0021-9746 (Print)
0021-9746
SP - 298-304
ST - Bilateral adrenal medullary hyperplasia: a clinicopathological entity
T2 - J Clin Pathol
TI - Bilateral adrenal medullary hyperplasia: a clinicopathological entity
VL - 28
ID - 3044
ER -
TY - JOUR
AB - OBJECTIVE: To determine whether patients with hypertensive urgency have a
higher risk for subsequent cardiovascular events compared with hypertensive
patients without this event. METHODS: Overall, 384 patients with hypertensive
urgency and 295 control patients were followed up for at least 2 years.
Hypertensive urgency was defined as a systolic blood pressure above 220 mmHg and/or
a diastolic blood pressure above 120 mmHg without any evidence of acute end-organ
damage. The control group consisted of patients admitted to the emergency
department with a systolic blood pressure between 135 to 180 mmHg and a diastolic
blood pressure between 85-110 mmHg. The number of cardiovascular events defined as
acute coronary syndrome, acute stroke, atrial fibrillation, acute left ventricular
failure and aortic aneurysm were consecutively analyzed during follow-up. The
median follow-up time was 4.2 years (interquartile range 2.9-5.7 years). Twenty-six
patients of the urgency group and 23 patients of the control group were lost for
follow-up. RESULTS: Overall, 117 (17%) patients had nonfatal clinical
cardiovascular events and 13 had (2%) fatal cardiovascular events. The frequency of
cardiovascular events was significantly higher in patients with hypertensive
urgencies (88 vs. 42; P = 0.005). The Cox regression analysis identified age (P <
0.001) and hypertensive urgencies (P = 0.035) as independent predictors for
subsequent cardiovascular events. CONCLUSIONS: Hypertensive urgencies are
associated with an increased risk for subsequent cardiovascular events in patients
with arterial hypertension.
AD - Department of Emergency Medicine, General Hospital, University of Vienna.
AN - 18327073
AU - Vlcek, M.
AU - Bur, A.
AU - Woisetschläger, C.
AU - Herkner, H.
AU - Laggner, A. N.
AU - Hirschl, M. M.
DA - Apr
DO - 10.1097/HJH.0b013e3282f4e8b6
DP - NLM
ET - 2008/03/11
IS - 4
KW - Acute Coronary Syndrome/epidemiology
Acute Disease
Adult
Aged
Aortic Aneurysm/epidemiology
*Blood Pressure
Emergency Medical Services/*statistics & numerical data
Female
Follow-Up Studies
Humans
Hypertension/*epidemiology
Male
Middle Aged
Risk Factors
Stroke/epidemiology
LA - eng
N1 - Vlcek, Marianne
Bur, Andreas
Woisetschläger, Christian
Herkner, Harald
Laggner, Anton N
Hirschl, Michael M
Journal Article
England
J Hypertens. 2008 Apr;26(4):657-62. doi: 10.1097/HJH.0b013e3282f4e8b6.
PY - 2008
SN - 0263-6352 (Print)
0263-6352
SP - 657-62
ST - Association between hypertensive urgencies and subsequent cardiovascular
events in patients with hypertension
T2 - J Hypertens
TI - Association between hypertensive urgencies and subsequent cardiovascular
events in patients with hypertension
VL - 26
ID - 2780
ER -
TY - JOUR
AB - BACKGROUND: The aim of this study was to investigate the early and late
outcomes of patients undergoing pulmonary embolectomy for acute massive pulmonary
embolus. METHODS: Twenty-one patients (15 male, 6 female) underwent pulmonary
embolectomy at our institution between March 2001 and July 2010. The median age was
55 years (range, 24 to 70 years). Of these, 9 patients presented with out-of-
hospital cardiac arrest and 8 presented with New York Heart Association class III
or IV. Sixteen patients underwent preoperative transthoracic echocardiography,
which showed evidence of right ventricular dilatation in all, whereas in 14
patients (66.6%) pulmonary artery pressures were significantly elevated with
moderate to severe tricuspid regurgitation. The median preoperative Euroscore was 9
(range, 3 to 16), and 11 patients (52.1%) received systemic thrombolysis
preoperatively. There were 6 salvage (28.5%), 10 emergency (47.6%), and 5 urgent
(23.8%) procedures. Concomitant procedures were performed in 3 patients (14.2%),
and surgery was performed without the use of cardiopulmonary bypass in 3 patients
(14.2%). The median follow-up was 38 months (range, 0 to 114 months). RESULTS: The
in-hospital mortality was 19% (n = 4). Postoperative complications included stroke
(n = 3, 14.2%), lower respiratory tract infection (n = 6, 28.5%), wound infection
(n = 3, 14.2%), acute renal failure requiring hemofiltration (n = 4, 19%), and
supraventricular tachyarrhythmias (n = 4, 19%). At discharge, transthoracic
echocardiography showed mild to moderate right ventricular dysfunction and
dilatation in 11 survivors (64.7%). Two patients died during follow-up, and
actuarial survival at 5 years was 76.9% ± 10.1% and at 8 years was 51.2% ± 22.0%.
At final follow-up, 11 of the 15 survivors (73.3%) were New York Heart Association
class I, and no patients required further intervention. CONCLUSIONS: Patients who
undergo surgery for massive pulmonary embolism have an acceptable outcome despite
being high-risk.
AD - Wessex Cardiothoracic Centre, Southampton University Hospitals NHS Trust,
Southampton, United Kingdom.
AN - 21095299
AU - Vohra, H. A.
AU - Whistance, R. N.
AU - Mattam, K.
AU - Kaarne, M.
AU - Haw, M. P.
AU - Barlow, C. W.
AU - Tsang, G. M.
AU - Livesey, S. A.
AU - Ohri, S. K.
DA - Dec
DO - 10.1016/j.athoracsur.2010.08.002
DP - NLM
ET - 2010/11/26
IS - 6
KW - Acute Kidney Injury/epidemiology/etiology
Adult
Aged
Angiography
Echocardiography
Embolectomy/*methods
Female
Follow-Up Studies
Humans
Incidence
Male
Middle Aged
Pulmonary Embolism/diagnosis/mortality/*surgery
Respiratory Tract Infections/epidemiology/etiology
Risk Factors
Tachycardia, Ventricular/epidemiology/etiology
Time Factors
Treatment Outcome
Young Adult
LA - eng
N1 - 1552-6259
Vohra, Hunaid A
Whistance, Robert N
Mattam, Kavitha
Kaarne, Marrkku
Haw, Marcus P
Barlow, Clifford W
Tsang, Geoffrey M K
Livesey, Steve A
Ohri, Sunil K
Journal Article
Netherlands
Ann Thorac Surg. 2010 Dec;90(6):1747-52. doi: 10.1016/j.athoracsur.2010.08.002.
PY - 2010
SN - 0003-4975
SP - 1747-52
ST - Early and late clinical outcomes of pulmonary embolectomy for acute massive
pulmonary embolism
TI - Early and late clinical outcomes of pulmonary embolectomy for acute massive
pulmonary embolism
VL - 90
ID - 2642
ER -
TY - JOUR
AB - AIMS: To assess the prognostic value of anti-apolipoprotein A-1 (anti-apoA-1)
IgG after myocardial infarction (MI) and its association with major cardiovascular
events (MACEs) at 12 months and to determine their association with resting heart
rate (RHR), a well-established prognostic feature after MI. Anti-apoA-1 IgG have
been reported in MI without autoimmune disease, but their clinical significance
remains undetermined. METHODS AND RESULTS: A total of 221 consecutive patients with
MI were prospectively included, and all completed a 12-month follow-up. Major
cardiovascular events consisted in death, MI, stroke, or hospitalization either for
an acute coronary syndrome or heart failure. Resting heart rate was obtained on
Holter the day before discharge under the same medical treatment. Neonate rat
ventricular cardiomyocytes (NRVC) were used in vitro to assess the direct anti-
apoA-1 IgG effect on RHR. During follow-up, 13% of patients presented a MACE. Anti-
apoA-1 IgG positivity was 9% and was associated with a higher RHR (P = 0.0005) and
higher MACE rate (adjusted OR, 4.3; 95% CI, 1.46-12.6; P = 0.007). Survival models
confirmed the significant nature of this association. Patients with MACE had higher
median anti-apoA-1 IgG values at admission than patients without (P = 0.007). On
NRVC, plasma from MI patients and monoclonal anti-apoA-1 IgG induced an aldosterone
and dose-dependent positive chronotropic effect, abrogated by apoA-1 and
therapeutic immunoglobulin (IVIG) pre-incubation. CONCLUSIONS: In MI patients,
anti-apoA-1 IgG is independently associated with MACE at 1-year, interfering with a
currently unknown aldosterone-dependent RHR determinant. Knowing whether anti-apoA-
1 IgG assessment could be of interest to identify an MI patient subset susceptible
to benefit from apoA-1/IVIG therapy remains to be demonstrated.
AD - Service of Laboratory Medicine, Department of Genetics and Laboratory
Medicine, Geneva University Hospitals, Geneva 14, Switzerland.
nicolas.vuilleumier@hcuge.ch
AN - 20176799
AU - Vuilleumier, N.
AU - Rossier, M. F.
AU - Pagano, S.
AU - Python, M.
AU - Charbonney, E.
AU - Nkoulou, R.
AU - James, R.
AU - Reber, G.
AU - Mach, F.
AU - Roux-Lombard, P.
DA - Apr
DO - 10.1093/eurheartj/ehq055
DP - NLM
ET - 2010/02/24
IS - 7
KW - Acute Coronary Syndrome/mortality
Adult
Aged
Aged, 80 and over
Animals
Apolipoprotein A-I/*immunology
Arrhythmias, Cardiac/*diagnosis/physiopathology
Dose-Response Relationship, Immunologic
Female
Heart Rate/immunology
Humans
Immunoglobulin G/*metabolism
Male
Middle Aged
Myocardial Infarction/*diagnosis/mortality/physiopathology
Myocytes, Cardiac/immunology
Prognosis
Prospective Studies
Rats
Rats, Wistar
Reference Values
Stroke/mortality
Treatment Outcome
LA - eng
N1 - 1522-9645
Vuilleumier, Nicolas
Rossier, Michel F
Pagano, Sabrina
Python, Magaly
Charbonney, Emmanuel
Nkoulou, René
James, Richard
Reber, Guido
Mach, François
Roux-Lombard, Pascale
Journal Article
England
Eur Heart J. 2010 Apr;31(7):815-23. doi: 10.1093/eurheartj/ehq055. Epub 2010 Feb
22.
PY - 2010
SN - 0195-668x
SP - 815-23
ST - Anti-apolipoprotein A-1 IgG as an independent cardiovascular prognostic
marker affecting basal heart rate in myocardial infarction
T2 - Eur Heart J
TI - Anti-apolipoprotein A-1 IgG as an independent cardiovascular prognostic
marker affecting basal heart rate in myocardial infarction
VL - 31
ID - 2616
ER -
TY - JOUR
AB - The Losartan Intervention For Endpoint reduction in hypertension (LIFE) study
provided extensive data on predisposing factors, consequences, and prevention of
atrial fibrillation (AF) in patients with hypertension and left ventricular (LV)
hypertrophy. Randomized losartan-based treatment was superior to atenolol-based
treatment for reducing new-onset AF and complications, especially stroke,
associated with new-onset or pre-existing AF. Potential mechanisms of AF prevention
by angiotensin receptor blockade supported by LIFE results include greater
reduction in left atrial size and LV hypertrophy. Differential effects of
antihypertensive treatment on the left atrium and left ventricle may help prevent
AF and reduce risk of stroke associated with hypertensive heart disease.
AD - Department of Cardiology B2142, The Heart Center, Rigshospitalet, 9
Blegdamsvej, DK-2100 Copenhagen, Denmark. kristian@wachtell.net
AN - 19124445
AU - Wachtell, K.
AU - Lyle, P. A.
AU - Okin, P. M.
AU - Gerdts, E.
DA - Dec
DO - 10.1177/1753944708093846
DP - NLM
ET - 2009/01/07
IS - 6
J2 - Therapeutic advances in cardiovascular disease
KW - Angiotensin II Type 1 Receptor Blockers/therapeutic use
Atrial Fibrillation/*epidemiology/*prevention & control
Humans
Hypertrophy, Left Ventricular/drug therapy/*epidemiology
Risk Factors
Risk Reduction Behavior
Stroke/*epidemiology/*prevention & control
LA - eng
N1 - Wachtell, Kristian
Devereux, Richard B
Lyle, Paulette A
Okin, Peter M
Gerdts, Eva
Journal Article
Review
England
Ther Adv Cardiovasc Dis. 2008 Dec;2(6):507-13. doi: 10.1177/1753944708093846. Epub
2008 Aug 21.
PY - 2008
SN - 1753-9447 (Print)
1753-9447
SP - 507-13
ST - The left atrium, atrial fibrillation, and the risk of stroke in hypertensive
patients with left ventricular hypertrophy
T2 - Ther Adv Cardiovasc Dis
TI - The left atrium, atrial fibrillation, and the risk of stroke in hypertensive
patients with left ventricular hypertrophy
VL - 2
ID - 2621
ER -
TY - JOUR
AB - OBJECTIVES: This study was designed to evaluate whether different
antihypertensive treatment regimens with similar blood pressure reduction have
different effects on new-onset atrial fibrillation (AF). BACKGROUND: It is unknown
whether angiotensin II receptor blockade is better than beta-blockade in preventing
new-onset AF. METHODS: In the Losartan Intervention For Endpoint reduction in
hypertension (LIFE) study 9,193 hypertensive patients and patients with
electrocardiogram-documented left ventricular hypertrophy were randomized to once-
daily losartan- or atenolol-based antihypertensive therapy. Electrocardiograms were
Minnesota coded centrally, and 8,851 patients without AF by electrocardiogram or
history, who were thus at risk of developing AF, were followed for 4.8 +/- 1.0
years. RESULTS: New-onset AF occurred in 150 patients randomized to losartan versus
221 to atenolol (6.8 vs. 10.1 per 1,000 person-years; relative risk 0.67, 95%
confidence interval [CI] 0.55 to 0.83, p < 0.001) despite similar blood pressure
reduction. Patients receiving losartan tended to stay in sinus rhythm longer (1,809
+/- 225 vs. 1,709 +/- 254 days from baseline, p = 0.057) than those receiving
atenolol. Moreover, patients with new-onset AF had two-, three- and fivefold
increased rates, respectively, of cardiovascular events, stroke, and
hospitalization for heart failure. There were fewer composite end points (n = 31
vs. 51, hazard ratio = 0.60, 95% CI 0.38 to 0.94, p = 0.03) and strokes (n = 19 vs.
38, hazard ratio = 0.49, 95% CI 0.29 to 0.86, p = 0.01) in patients who developed
new-onset AF in the losartan compared to the atenolol treatment arm of the study.
Furthermore, Cox regression analysis showed that losartan (21% risk reduction) and
new-onset AF both independently predicted stroke even when adjusting for
traditional risk factors. CONCLUSIONS: Our novel finding is that new-onset AF and
associated stroke were significantly reduced by losartan- compared to atenolol-
based antihypertensive treatment with similar blood pressure reduction.
AD - Department of Medicine, Glostrup University Hospital, Glostrup, Denmark.
kristian@wachtell.net
AN - 15734615
AU - Wachtell, K.
AU - Lehto, M.
AU - Gerdts, E.
AU - Olsen, M. H.
AU - Hornestam, B.
AU - Dahlöf, B.
AU - Ibsen, H.
AU - Julius, S.
AU - Lindholm, L. H.
DA - Mar 1
DO - 10.1016/j.jacc.2004.10.068
DP - NLM
ET - 2005/03/01
IS - 5
Aged
Aged, 80 and over
Angiotensin II Type 1 Receptor Blockers/*therapeutic use
Atrial Fibrillation/*drug therapy/mortality
Cause of Death
Double-Blind Method
Female
Humans
Hypertension/*drug therapy/mortality
Hypertrophy, Left Ventricular/*drug therapy/mortality
Male
Middle Aged
Prospective Studies
Risk Factors
Stroke/*drug therapy/mortality
Survival Rate
LA - eng
N1 - Wachtell, Kristian
Lehto, Mika
Gerdts, Eva
Olsen, Michael H
Hornestam, Björn
Dahlöf, Björn
Ibsen, Hans
Julius, Stevo
Kjeldsen, Sverre E
Lindholm, Lars H
Nieminen, Markku S
Devereux, Richard B
Clinical Trial
Comparative Study
Journal Article
Multicenter Study
United States
J Am Coll Cardiol. 2005 Mar 1;45(5):712-9. doi: 10.1016/j.jacc.2004.10.068.
PY - 2005
SN - 0735-1097 (Print)
0735-1097
SP - 712-9
ST - Angiotensin II receptor blockade reduces new-onset atrial fibrillation and
subsequent stroke compared to atenolol: the Losartan Intervention For End Point
Reduction in Hypertension (LIFE) study
TI - Angiotensin II receptor blockade reduces new-onset atrial fibrillation and
subsequent stroke compared to atenolol: the Losartan Intervention For End Point
Reduction in Hypertension (LIFE) study
VL - 45
ID - 2591
ER -
TY - JOUR
AB - In contrast with Steinert's disease (DM1), type 2 muscular dystrophy (DM2) is
not known to be associated with a high prevalence of cardiac involvement. Our
objective was to compare the results of detailed cardiac investigations in
populations of DM2 and DM1 patients, and in controls. Thirty-eight DM2 patients (17
males; age=57.1+/-15.2years) were investigated for possible heart involvement, and
their results compared with 76 age-sex matched DM1 patients and 76 controls.
Cardiac abnormalities were present in 15 DM2 patients, including conductive defects
in 14, systolic dysfunction in 6, supraventricular arrhythmias in 6 and stroke in 5
patients and were significantly more frequent than in controls. When compared to
DM1 patients, conductive defects were less frequent, supraventricular arrhythmias
had similar prevalence and there was a trend towards more frequent left ventricular
dysfunction in DM2 patients. Our study suggests that systematic cardiac
investigations should be recommended in these patients.
AD - Myology Institute, Pitié-Salpétrière Hospital, APHP, 47-83 boulevard de
l'Hôpital, Paris Cedex 13, France. karim.wahbi@psl.aphp.fr
AN - 19481939
AU - Wahbi, K.
AU - Meune, C.
AU - Bécane, H. M.
AU - Laforêt, P.
AU - Bassez, G.
AU - Lazarus, A.
AU - Radvanyi-Hoffman, H.
AU - Eymard, B.
AU - Duboc, D.
DA - Jul
DO - 10.1016/j.nmd.2009.04.012
DP - NLM
ET - 2009/06/02
IS - 7
J2 - Neuromuscular disorders : NMD
KW - Adult
Aged
Arrhythmias, Cardiac/diagnosis/*epidemiology/*physiopathology
Comorbidity
Echocardiography/standards
Electrocardiography/standards
Female
Genetic Predisposition to Disease/genetics
Genetic Testing
Heart Arrest/etiology/metabolism/physiopathology
Heart Ventricles/metabolism/pathology/physiopathology
Humans
Male
Mass Screening
Middle Aged
Myocardium/metabolism/pathology
Myotonic Disorders/*epidemiology/genetics/*physiopathology
Prevalence
Stroke/etiology/metabolism/physiopathology
Ventricular Dysfunction, Left/diagnosis/*epidemiology/*physiopathology
LA - eng
N1 - 1873-2364
Wahbi, Karim
Meune, Christophe
Bécane, Henri Marc
Laforêt, Pascal
Bassez, Guillaume
Lazarus, Arnaud
Radvanyi-Hoffman, Hélène
Eymard, Bruno
Duboc, Denis
Journal Article
England
Neuromuscul Disord. 2009 Jul;19(7):468-72. doi: 10.1016/j.nmd.2009.04.012. Epub
2009 May 29.
PY - 2009
SN - 0960-8966
SP - 468-72
ST - Left ventricular dysfunction and cardiac arrhythmias are frequent in type 2
myotonic dystrophy: a case control study
T2 - Neuromuscul Disord
TI - Left ventricular dysfunction and cardiac arrhythmias are frequent in type 2
myotonic dystrophy: a case control study
VL - 19
ID - 2380
ER -
TY - JOUR
AB - OBJECTIVE: In patients with a prior stroke or transient ischemic attack (TIA)
and atrial fibrillation anticoagulant treatment is indicated. This study's purpose
was to investigate if echocardiography can predict unknown AF in patients after
stroke. DESIGN: Prospectively, 174 stroke/TIA patients without diagnosed AF
underwent echocardiographic evaluation including tissue Doppler imaging (TDI)
focusing on functional parameters of the left atrium and left ventricular diastolic
function. AF screening was performed during 30 d. RESULTS: Fifteen patients (8.6%)
were diagnosed with AF. Echocardiography in the AF group compared to those without
AF, showed larger left atrial volume index (LAVI), (37.2 ± 6.7 vs. 31.6 ± 8.6
ml/m(2), p = 0.018), lower A' velocities in ventricular (5.9 ± 2.2 vs. 7.2 ± 1.6,
p = 0.010) and atrial (4.8 ± 1.4 vs. 5.9 ± 1.4, p = 0.013) septa, higher LAVI/A' in
ventricular septum (6.7 (5.0-8.7) vs. 4.2 (3.2-5.5), p = 0.001) and atrial septum
(8.5 (5.9-11.0) vs. 5.1 (4.1-6.8), p = 0.003). Receiver operating characteristic
analyses to detect AF was performed, area under the curve for LAVI was 0.71 (0.61-
0.83), p = 0.008, and for LAVI/A' in ventricular septum 0.76 (0.59-0.93), p = 0.006
and atrial septum 0.78 (0.63-0.93), p = 0.002, respectively. CONCLUSIONS: LAVI and
measures of atrial contraction as measured by TDI predict unknown AF in patients
after an stroke/TIA and may be used to detect silent AF.
AD - a Department of Clinical Sciences, Karolinska Institutet , Danderyd
University Hospital Stockholm , Sweden ;
b Department of Medicine , Ersta Hospital , Stockholm , Sweden ;
c Department of Medicine , Halland Hospital , Halmstad , Sweden.
AN - 27192631
AU - Waldenhjort, D.
AU - Sobocinski Doliwa, P.
AU - Alam, M.
AU - Frykman-Kull, V.
AU - Engdahl, J.
AU - Rosenqvist, M.
AU - Persson, H.
DA - Aug
DO - 10.1080/14017431.2016.1175657
DP - NLM
ET - 2016/05/19
IS - 4
J2 - Scandinavian cardiovascular journal : SCJ
KW - Aged
Asymptomatic Diseases
*Atrial Fibrillation/complications/diagnosis/physiopathology
Female
Humans
Male
Atrial fibrillation
echocardiography
ischemic stroke
LA - eng
N1 - 1651-2006
Waldenhjort, David
Sobocinski Doliwa, Piotr
Alam, Mahbubul
Frykman-Kull, Viveka
Engdahl, Johan
Rosenqvist, Mårten
Persson, Hans
Journal Article
England
Scand Cardiovasc J. 2016 Aug;50(4):236-42. doi: 10.1080/14017431.2016.1175657. Epub
2016 May 18.
PY - 2016
SN - 1401-7431
SP - 236-42
ST - Echocardiographic measures of atrial function may predict atrial fibrillation
in stroke patients
T2 - Scand Cardiovasc J
TI - Echocardiographic measures of atrial function may predict atrial fibrillation
in stroke patients
VL - 50
ID - 2360
ER -
TY - JOUR
AB - BACKGROUND: Although the association between cerebrovascular and coronary
artery disease (CAD) is well known in high-income countries, this association is
not well documented in black Africans. AIMS: The aim of this study was to document
electrocardiographic (ECG) evidence of CAD in stroke cases and controls and to
identify other common ECG abnormalities related to known stroke risk factors in a
community-based population of incident stroke cases in Tanzania, East Africa.
METHODS: This was a case-control study. Incident stroke cases were identified by
the Tanzanian Stroke Incidence Project. Age- and sex-matched controls were randomly
selected from the background population. Electrocardiograms were manually analyzed
using the Minnesota Coding System, looking for evidence of previous myocardial
infarction (MI), atrial fibrillation (AF) or atrial flutter (AFl), and left
ventricular hypertrophy (LVH). RESULTS: In Hai, there were 93 cases and 241
controls with codable electrocardiograms, and in Dar-es-Salaam, there were 39 cases
and 72 controls with codable electrocardiograms. Comparing cases and controls,
there was a higher prevalence of MI and AF or AFl (but not LVH) in cases compared
with controls. CONCLUSIONS: This is the first published study of ECG assessment of
CAD and other stroke risk factors in an incident population of stroke cases in sub-
Saharan Africa. It suggests that concomitant CAD in black African stroke cases is
more common than previously suggested.
AD - Department of Medicine, North Tyneside General Hospital, Rake Lane, North
Shields, Tyne and Wear, UK; Institute of Health and Society, Newcastle University,
Newcastle-upon-Tyne, UK. Electronic address: Richard.walker@nhct.nhs.uk.
Department of Medicine, North Tyneside General Hospital, Rake Lane, North Shields,
Tyne and Wear, UK; Institute of Health and Society, Newcastle University,
Newcastle-upon-Tyne, UK.
Department of Medicine, North Tyneside General Hospital, Rake Lane, North Shields,
Tyne and Wear, UK.
Department of Radiology, Kilimanjaro Christian Medical Centre, Moshi, United
Republic of Tanzania.
Department of Neurology, Muhimbili University Hospital, Dar-es-Salaam, United
Republic of Tanzania.
Faculty of Medical Sciences, Cave Hill Campus, University of the West Indies,
Barbados.
Department of Cardiology, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Royal
Victoria Infirmary, Newcastle-upon-Tyne, UK.
Department of Medicine, Muhimbili University College Hospital, Dar-es-Salaam,
United Republic of Tanzania.
AN - 23545320
AU - Walker, R. W.
AU - Dewhurst, M.
AU - Gray, W. K.
AU - Jusabani, A.
AU - Aris, E.
AU - Unwin, N.
AU - Swai, M.
AU - Adams, P. C.
AU - Mugusi, F.
C2 - PMC4185096
DA - Feb
DP - NLM
ET - 2013/04/03
IS - 2
KW - *African Continental Ancestry Group
Aged
Atrial Fibrillation/diagnosis/ethnology
Atrial Flutter/diagnosis/ethnology
Coronary Artery Disease/*diagnosis/*ethnology
Developing Countries
Female
Humans
Hypertrophy, Left Ventricular/diagnosis/ethnology
Incidence
Male
Middle Aged
Myocardial Infarction/diagnosis/ethnology
Prevalence
Prognosis
Risk Assessment
Risk Factors
*Rural Health
Stroke/diagnosis/*ethnology
Tanzania/epidemiology
*Urban Health
Electrocardiography
Tanzania
stroke
sub-Saharan Africa
LA - eng
N1 - 1532-8511
Walker, Richard W
Dewhurst, Matthew
Gray, William K
Jusabani, Ahmed
Aris, Eric
Unwin, Nigel
Swai, Mark
Adams, Philip C
Mugusi, Ferdinand
066939/Wellcome Trust/United Kingdom
Journal Article
Multicenter Study
10.1016/j.jstrokecerebrovasdis.2013.03.002. Epub 2013 Mar 30.
PY - 2014
SN - 1052-3057 (Print)
1052-3057
SP - 315-20
ST - Electrocardiographic assessment of coronary artery disease and stroke risk
factors in rural and urban Tanzania: a case-control study
TI - Electrocardiographic assessment of coronary artery disease and stroke risk
factors in rural and urban Tanzania: a case-control study
VL - 23
ID - 2374
ER -
TY - JOUR
AB - Atrial fibrillation occurs commonly in the setting of congestive heart
failure and, in fact can cause left ventricular dysfunction due to a rapid
ventricular response over time, termed tachycardia-mediated cardiomyopathy. The
combination of atrial fibrillation and congestive heart failure leads to a high
risk of stroke for the patient and appropriate antithrombotic therapy can minimize
this incidence of stroke. Stroke risk can be markedly reduced by treatment with
warfarin and complications of anticoagulation minimized by close attention to
maintaining the INR between 2.0 and 3.0.
AD - The Care Group, LLC.
AN - 12215731
AU - Walsh, M. N.
AU - Prystowsky, E. N.
DA - Jul
DO - 10.1023/a:1020081327269
DP - NLM
ET - 2002/09/07
IS - 3
J2 - Heart failure reviews
KW - Adult
Aged
Humans
Middle Aged
Prognosis
LA - eng
N1 - Walsh, Mary Norine
Prystowsky, Eric N
Journal Article
Review
United States
Heart Fail Rev. 2002 Jul;7(3):261-6. doi: 10.1023/a:1020081327269.
PY - 2002
SN - 1382-4147 (Print)
1382-4147
SP - 261-6
ST - Anti-thrombotic strategies for patients with atrial fibrillation and heart
failure
T2 - Heart Fail Rev
TI - Anti-thrombotic strategies for patients with atrial fibrillation and heart
failure
VL - 7
ID - 2678
ER -
TY - JOUR
AB - Cardiovascular mortality has remained high in patients on peritoneal dialysis
(PD) due to the high prevalence of various cardiovascular complications including
coronary artery disease, left ventricular hypertrophy and dysfunction, heart
failure, arrhythmia (especially atrial fibrillation), cerebrovascular disease, and
peripheral arterial disease. In addition, nearly a quarter of PD patients develop
sudden cardiac death as the terminal life event. Thus, it is essential to identify
effective treatment that may lower cardiovascular mortality and improve survival of
PD patients. The International Society for Peritoneal Dialysis (ISPD) commissioned
a global workgroup in 2012 to formulate a series of recommendation statements
regarding lifestyle modification, assessment and management of various
cardiovascular risk factors, and management of the various cardiovascular
complications to be published in 2 guideline documents. This publication forms the
second part of the guideline documents and includes recommendation statements on
the management of various cardiovascular complications in adult chronic PD
patients. The documents are intended to serve as a global clinical practice
guideline for clinicians who look after PD patients. We also define areas where
evidence is clearly deficient and make suggestions for future research in each
specific area.
AD - Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong
Kong aymwang@hkucc.hku.hk.
St. Joseph's Healthcare, McMaster University, Hamilton, Ontario, Canada.
Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, Ontario,
Canada.
Division of Nephrology, The Royal Melbourne Hospital, University of Melbourne,
Melbourne, Australia.
George Institute for Global Health India, Postgraduate Institute of Medical
Education and Research, Chandigarh, India.
University of Queensland at Princess Alexandra Hospital, Brisbane, Australia Centre
for Kidney Disease Research, Translational Research Institute, Brisbane, Australia.
Department of Internal Medicine, College of Medicine, Severance Biomedical Science
Institute, Yonsei University, Korea.
Division of Nephrology, University Hospital Maastricht, Maastricht, The
Netherlands.
Health Services Research Unit, Institute for Science and Technology in Medicine,
Keele University, Keele, Staffordshire, United Kingdom.
School of Medicine, University of Nottingham, Royal Derby Hospital Centre, Derby,
United Kingdom.
Harborview Medical Center, Division of Nephrology/Department of Medicine,
University of Washington, Washington, DC, United States.
School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná,
Brazil.
AN - 26228783
AU - Wang, A. Y.
AU - Brimble, K. S.
AU - Brunier, G.
AU - Holt, S. G.
AU - Jha, V.
AU - Johnson, D. W.
AU - Kang, S. W.
AU - Kooman, J. P.
AU - Lambie, M.
AU - McIntyre, C.
AU - Mehrotra, R.
AU - Pecoits-Filho, R.
C2 - PMC4520721
DA - Jul-Aug
DO - 10.3747/pdi.2014.00278
DP - NLM
ET - 2015/08/01
IS - 4
J2 - Peritoneal dialysis international : journal of the International Society for
Peritoneal Dialysis
KW - Atrial Fibrillation/etiology/mortality
Cardiovascular Diseases/*etiology/mortality/pathology/*therapy
Coronary Artery Disease/etiology/mortality
Female
Humans
Hypertrophy, Left Ventricular/etiology/mortality
Male
Peritoneal Dialysis/*adverse effects/standards
Prognosis
Societies, Medical
Survival Analysis
*Coronary artery disease
*heart failure
*peripheral artery disease
*peritoneal dialysis
*stroke
*sudden cardiac death
LA - eng
N1 - 1718-4304
Wang, Angela Yee Moon
Brimble, K Scott
Brunier, Gillian
Holt, Stephen G
Jha, Vivekanand
Johnson, David W
Kang, Shin-Wook
Kooman, Jeroen P
Lambie, Mark
McIntyre, Chris
Mehrotra, Rajnish
Pecoits-Filho, Roberto
Journal Article
Review
Perit Dial Int. 2015 Jul-Aug;35(4):388-96. doi: 10.3747/pdi.2014.00278.
PY - 2015
SN - 0896-8608 (Print)
0896-8608
SP - 388-96
ST - ISPD Cardiovascular and Metabolic Guidelines in Adult Peritoneal Dialysis
Patients Part II - Management of Various Cardiovascular Complications
T2 - Perit Dial Int
TI - ISPD Cardiovascular and Metabolic Guidelines in Adult Peritoneal Dialysis
Patients Part II - Management of Various Cardiovascular Complications
VL - 35
ID - 2470
ER -
TY - JOUR
AN - 18004143
AU - Wang, P. S.
AU - Schneeweiss, S.
AU - Setoguchi, S.
AU - Patrick, A.
AU - Avorn, J.
AU - Mogun, H.
AU - Choudhry, N. K.
AU - Brookhart, M. A.
DA - Dec
DO - 10.1097/JCP.0b013e31815a882b
DP - NLM
ET - 2007/11/16
IS - 6
J2 - Journal of clinical psychopharmacology
Aged
Antipsychotic Agents/administration & dosage/*adverse effects/therapeutic use
Aripiprazole
Arrhythmias, Cardiac/*chemically induced
Benzodiazepines/adverse effects/therapeutic use
Clozapine/adverse effects/therapeutic use
Databases, Factual/statistics & numerical data
Dementia/drug therapy
Dibenzothiazepines/adverse effects/therapeutic use
Drug Utilization Review/statistics & numerical data
Health Services for the Aged/statistics & numerical data
Humans
Olanzapine
Pharmaceutical Services/statistics & numerical data
Piperazines/adverse effects/therapeutic use
Quetiapine Fumarate
Quinolones/adverse effects/therapeutic use
Risperidone/adverse effects/therapeutic use
Stroke/*chemically induced
Thiazoles/adverse effects/therapeutic use
Treatment Outcome
LA - eng
N1 - Wang, Philip S
Schneeweiss, Sebastian
Setoguchi, Soko
Patrick, Amanda
Avorn, Jerry
Mogun, Helen
Choudhry, Niteesh K
Brookhart, M Alan
R01 MH 069772/MH/NIMH NIH HHS/United States
Letter
United States
J Clin Psychopharmacol. 2007 Dec;27(6):707-10. doi: 10.1097/JCP.0b013e31815a882b.
PY - 2007
SN - 0271-0749 (Print)
0271-0749
SP - 707-10
ST - Ventricular arrhythmias and cerebrovascular events in the elderly using
conventional and atypical antipsychotic medications
T2 - J Clin Psychopharmacol
TI - Ventricular arrhythmias and cerebrovascular events in the elderly using
conventional and atypical antipsychotic medications
VL - 27
ID - 2857
ER -
TY - JOUR
AB - BACKGROUND: Sympathetic neural activation plays a key role in the incidence
and maintenance of acute myocardial infarction (AMI) induced ventricular arrhythmia
(VA). Furthermore, previous studies showed that AMI might induce microglia and
sympathetic activation and that microglial activation might contribute to
sympathetic activation. Recently, studies showed that light emitting diode (LED)
therapy might attenuate microglial activation. Therefore, we hypothesized that LED
therapy might reduce AMI-induced VA by attenuating microglia and sympathetic
activation. METHODS: Thirty anesthetized rats were randomly divided into three
groups: the Control group (n = 6), AMI group (n = 12), and AMI + LED group (n =
12). Electrocardiogram (ECG) and left stellate ganglion (LSG) neural activity were
continuously recorded. The incidence of VAs was recorded during the first hour
after AMI. Furthermore, we sampled the brain and myocardium tissue of the different
groups to examine the microglial activation and expression of nerve growth factor
(NGF), interleukin-18 (IL-18), and IL-1β, respectively. RESULTS: Compared to the
AMI group, LED therapy significantly reduced the incidence of AMI-induced VAs
(ventricular premature beats [VPB] number: 85.08 ± 13.91 vs 27.5 ± 9.168, P < .01;
nonsustained ventricular tachycardia (nSVT) duration: 34.39 ± 8.562 vs 9.005 ±
3.442, P < .05; nSVT number: 18.92 ± 4.52 vs 7.583 ± 3.019, P < .05; incidence rate
of SVT/VF: 58.33% vs. 8.33%, P < .05) and reduced the LSG neural activity (P < .01)
in the AMI + LED group. Furthermore, LED significantly attenuated microglial
activation and reduced IL-18, IL-1β, and NGF expression in the peri-infarct
myocardium. CONCLUSION: LED therapy may protect against AMI-induced VAs by
suppressing sympathetic neural activity and the inflammatory response.
AD - Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular
Research Institute of Wuhan University, Wuhan, Hubei, People's Republic of China.
Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University
School of Medicine, Shanghai, People's Republic of China.
AN - 31104349
AU - Wang, S.
AU - Wu, L.
AU - Zhai, Y.
AU - Li, X.
AU - Li, B.
AU - Zhao, D.
AU - Jiang, H.
DA - Jul
DO - 10.1111/jce.13974
DP - NLM
ET - 2019/05/20
IS - 7
KW - *acute myocardial infarction
*left stellate ganglion
*light emitting diode
*microglia
*ventricular arrhythmia
LA - eng
N1 - 1540-8167
Wang, Songyun
Wu, Lin
Zhai, Yi
Li, Xuemeng
Li, Binxun
Zhao, Dongdong
Jiang, Hong
Orcid: 0000-0003-2177-2272
81270339/National Natural Science Foundation of China/International
2042018kf0102/Fundamental Research Funds for the Central Universities/International
RMYD2018M37/Renmin Hospital of Wuhan University/International
Journal Article
United States
J Cardiovasc Electrophysiol. 2019 Jul;30(7):1138-1147. doi: 10.1111/jce.13974. Epub
2019 Jun 4.
PY - 2019
SN - 1045-3873
SP - 1138-1147
ST - Noninvasive light emitting diode therapy: A novel approach for postinfarction
ventricular arrhythmias and neuroimmune modulation
TI - Noninvasive light emitting diode therapy: A novel approach for postinfarction
ventricular arrhythmias and neuroimmune modulation
VL - 30
ID - 3079
ER -
TY - JOUR
AB - BACKGROUND: Patients with heart failure (HF) and a normal left ventricular
ejection fraction usually present with diastolic dysfunction (DD). Whether
intraleft ventricular contractile dyssynchrony (IVCD) coexists with DD and
contributes to the clinical manifestations of HF remains unclear. The study
investigated the IVCD at rest and after exercise in hypertensive patients with
diastolic HF (DHF). METHODS: Echocardiography was performed in 60 hypertensive
patients with narrow QRS, left ventricular ejection fraction > or = 50%, and no
active ischemia. Patients were grouped as having DD (mitral E/A < 1 plus E
deceleration time > 200 milliseconds, or mitral annular early diastolic velocity <
8 cm/s; n = 26), DD plus HF symptoms/signs (DHF, n = 13), or as non-DD (n = 21).
RESULTS: At rest, the IVCD index (SD of 12 left ventricular segmental
electromechanical delays) was greater in the DHF and DD groups than that in the
non-DD group (52.2 +/- 10.7 and 39.1 +/- 23.6 vs 23.1 +/- 19.9 milliseconds; P < .
05 for both comparisons). Six-minute treadmill exercise induced exacerbation of
dyssynchrony in the DHF group (67.0 +/- 12.9 vs 52.2 +/- 10.7 milliseconds; P < .
001). Multivariate analysis revealed that the combination of IVCD index > or = 35
milliseconds at rest and > or = 50 milliseconds after exercise was independently
associated with DHF (odds ratio = 20, 95% CI = 2-199, P = .009). Postexercise IVCD
index correlated positively with plasma N-terminal pro-brain natriuretic peptide (r
= 0.37, P = .004). CONCLUSIONS: Exercise would aggravate intraventricular
dyssynchrony in hypertensive patients with DHF, implicating a potential
contribution of systolic dyssynchrony to clinical manifestations.
AD - Department of Internal Medicine, National Taiwan University Hospital, Taipei,
Taiwan.
AN - 17643577
AU - Wang, Y. C.
AU - Hwang, J. J.
AU - Lai, L. P.
AU - Tsai, C. T.
AU - Lin, L. C.
AU - Katra, R.
AU - Lin, J. L.
DA - Aug
DO - 10.1016/j.ahj.2007.04.008
DP - NLM
ET - 2007/07/24
IS - 2
KW - Adult
Aged
Aged, 80 and over
Arrhythmias, Cardiac
Diastole/physiology
Echocardiography
Exercise Test/*adverse effects
Female
Heart Failure/complications/diagnostic imaging/*physiopathology
Humans
Male
Middle Aged
Myocardial Contraction/physiology
Stroke Volume
Ventricular Dysfunction, Left/diagnostic imaging/*etiology/physiopathology
LA - eng
N1 - 1097-6744
Wang, Yi-Chih
Hwang, Juey-Jen
Lai, Ling-Ping
Tsai, Chia-Ti
Lin, Lung-Chun
Katra, Rodolphe
Lin, Jiunn-Lee
Comparative Study
Journal Article
United States
Am Heart J. 2007 Aug;154(2):278-84. doi: 10.1016/j.ahj.2007.04.008.
PY - 2007
SN - 0002-8703
SP - 278-84
ST - Coexistence and exercise exacerbation of intraleft ventricular contractile
dyssynchrony in hypertensive patients with diastolic heart failure
T2 - Am Heart J
TI - Coexistence and exercise exacerbation of intraleft ventricular contractile
dyssynchrony in hypertensive patients with diastolic heart failure
VL - 154
ID - 3036
ER -
TY - JOUR
AB - BACKGROUND: Large-scale clinical trials have demonstrated that patients with
atrial fibrillation (AF), when treated with a rhythm-control strategy, are still at
risk for embolic events. We hypothesized that left atrial (LA) dysfunction
persisted even after successful maintenance of sinus rhythm for > 3 months.
METHODS: A total of 93 patients with AF and satisfactory rhythm control for > 3
months were included. Satisfactory rhythm control was defined as being free of AF
based on patient-reported symptoms, monthly ECG follow-up, and ambulatory Holter
ECG if needed. Among the 93 patients, 25 patients had sustained AF that was
terminated by electrical or pharmacologic cardioversion, while 68 patients had
paroxysmal AF under good medical control. Clinical data were obtained, and
transthoracic and transesophageal echocardiography were performed after
satisfactory rhythm control for > 3 months. RESULTS: Among the 93 patients, 34
patients (37%) had LA dysfunction, defined as LA appendage (LAA) peak emptying
velocity < 40 cm/s or spontaneous echo contrast and/or thrombus in the LA or LAA.
When compared to the other 59 patients without LA dysfunction, they had larger LA
dimension (40 +/- 6 mm vs 36 +/- 8 mm [+/- SD], p = 0.018) but did not differ
significantly regarding the left ventricular (LV) chamber size, LV ejection
fraction, mitral or tricuspid inflow, and ratio of the amplitude of the waves
created by early diastolic filling and atrial contraction. We also analyzed the
relationship between LA function and clinical risk factors for stroke, including
hypertension, diabetes mellitus, coronary artery disease, age > 65 years, and prior
cerebral vascular accident. LA dysfunction was found in 10 of 17 patients (59%)
with three or more risk factors. The odds ratio for having LA dysfunction was 3.1
(p = 0.04; 95% confidence interval, 1.1 to 9.1) when compared with patients with
less than three risk factors. CONCLUSIONS: LA dysfunction was present in more than
one third of AF patients after satisfactory rhythm control for > 3 months. Patients
with higher burden (three or more) of clinical risk factors were more likely to
have impaired LA function.
AD - Department of Internal Medicine, National Taiwan University Hospital Yun-Lin
Branch, Yun-Lin, Taiwan.
AN - 16236922
AU - Wang, Y. C.
AU - Lin, J. L.
AU - Hwang, J. J.
AU - Lin, M. S.
AU - Tseng, C. D.
AU - Huang, S. K.
AU - Lai, L. P.
DA - Oct
DO - 10.1378/chest.128.4.2551
DP - NLM
ET - 2005/10/21
IS - 4
J2 - Chest
KW - Aged
Atrial Fibrillation/classification/drug therapy/*therapy
Electrocardiography
Female
Humans
Male
Middle Aged
Time Factors
Treatment Outcome
LA - eng
N1 - Wang, Yi-Chih
Lin, Jiunn-Lee
Hwang, Juey-Jen
Lin, Mao-Shin
Tseng, Chuen-Den
Huang, Shoei K Stephen
Lai, Ling-Ping
Journal Article
United States
PY - 2005
SN - 0012-3692 (Print)
0012-3692
SP - 2551-6
ST - Left atrial dysfunction in patients with atrial fibrillation after successful
rhythm control for > 3 months
T2 - Chest
TI - Left atrial dysfunction in patients with atrial fibrillation after successful
rhythm control for > 3 months
VL - 128
ID - 2895
ER -
TY - JOUR
AB - Objective: To determine the predictors of recurrent hospitalizations among
atrial fibrillation (AF) patients. Methods: We analyzed data from the Chinese
Atrial Fibrillation Registry (CAFR), a prospective cohort study involving non-
valvular atrial fibrillation (NVAF) patients from Augest 2011 to December 2017. A
total of 5 349 NVAF patients with a minimum of 48 months follow-up were included
for analysis. Data including patient demographics, complications, medical and
ablation history were collected. The maximum number of all-cause hospitalizations
within one-year for each patient served as the primary endpoint. Patients
hospitalized less than twice within one-year were defined as non-recurrent
hospitalizations group, those hospitalized at least twice within one-year were
definned as recurrent hospitalizations group. Logistic regression model was used to
identify associated risk factors for recurrent hospitalizations. Results: Of 5 349
NVAF patients, those hospitalized for 0, 1, 2, 3, 4 and at least 5 times within
one-year was 2 703 (50.5%), 1 776 (33.2%), 642 (12.0%), 161(3.0), 52 (1.0%), 15
(0.3%), respectively. Eight hundred and seventy (16.3%) patients were included in
recurrent hospitalizations group, 4 479 (83.7%) patients were included in non-
recurrent hospitalizations group. Compare with non-recurrent hospitalizations
group, patients in recurrent hospitalizations group was more likely to be older and
female, more frequently had a history of hypertension, heart failure, coronary
heart disesase, ischaemic stroke/transient ischaemic attack, diabetes mellitus,
peptic ulcer, a AF duration for more than 1 year, medication including drugs for
ventricular rate control, statin, angiotensin-converting enzyme inhibitors
(ACEI)/angiotensin receptor blocker (ARB) and higher CHA(2)DS(2)-VASc scores
(P<0.05), but less frequently had higher education, a history of drinking, smoking
and ablation (P<0.05). Multivariable analysis showed that age 50-64 (OR=1.47, 95%CI
1.20-1.80), age≥65 (OR=1.89, 95%CI 1.50-2.38), female (OR=1.21, 95%CI 1.01-1.46),
hypertension history (OR=1.42, 95%CI 1.16-1.74), heart failure history (OR=1.73,
95%CI 1.37-2.18), coronary heart disease history (OR=1.63, 95%CI 1.31-2.03), peptic
ulcer history (OR=2.00, 95%CI 1.18-3.39) were independent risk factors for
recurrent hospitalizations, while higher education (college or above) (OR=0.82,
95%CI 0.69-0.99) was the protective factor for recurrent hospitalizations.
Conclusions: Nearly 1 in 6 of AF patients were admitted to hospital more than once
within one year in this NVAF cohort. Age≥50, female, hypertension history, heart
failure history, coronary heart disease history, peptic ulcer history are
associated with an increased risk of recurrent hospitalizations.
AD - Department of Cardiology, Beijing Anzhen Hospital, Capital Medical
AN - 32370482
AU - Wang, Y. F.
AU - Lu, S. X.
AU - Xia, S. J.
AU - Jia, Z. X.
AU - Jiang, C.
AU - He, L.
AU - Du, X.
AU - Ma, C. S.
DA - Apr 24
DO - 10.3760/cma.j.cn112148-20190727-00433
DP - NLM
ET - 2020/05/07
IS - 4
KW - *Atrial Fibrillation
*Brain Ischemia
Female
Hospitalization
Humans
Male
Prospective Studies
Risk Factors
*Stroke
Atrial fibrillation
Risk factor
LA - chi
N1 - Wang, Y F
Lu, S X
Xia, S J
Jia, Z X
Jiang, C
He, L
Du, X
Ma, C S
2016YFC0900901, 2016YFC1301002/National Key Research and Development Plan/
81530016/National Natural Science Foundation of China/
Journal Article
China
Zhonghua Xin Xue Guan Bing Za Zhi. 2020 Apr 24;48(4):308-314. doi:
10.3760/cma.j.cn112148-20190727-00433.
PY - 2020
SN - 0253-3758 (Print)
0253-3758
SP - 308-314
ST - [Risk factors for recurrent hospitalizations of patients with atrial
fibrillation]
TI - [Risk factors for recurrent hospitalizations of patients with atrial
fibrillation]
VL - 48
ID - 2711
ER -
TY - JOUR
AB - BACKGROUND: Digoxin is a widely used drug for ventricular rate control in
patients with atrial fibrillation (AF), despite a scarcity of randomised trial
data. We studied the use and outcomes of digoxin in patients in the Rivaroxaban
Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for
Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF).
METHODS: For this retrospective analysis, we included and classified patients from
ROCKET AF on the basis of digoxin use at baseline and during the study. Patients in
ROCKET AF were recruited from 45 countries and had AF and risk factors putting them
at moderate-to-high risk of stroke, with or without heart failure. We used Cox
proportional hazards regression models adjusted for baseline characteristics and
drugs to investigate the association of digoxin with all-cause mortality, vascular
death, and sudden death. ROCKET AF was registered with ClinicalTrials.gov, number
NCT00403767. FINDINGS: In 14,171 randomly assigned patients, digoxin was used at
baseline in 5239 (37%). Patients given digoxin were more likely to be female (42%
vs 38%) and have a history of heart failure (73% vs 56%), diabetes (43% vs 38%),
and persistent AF (88% vs 77%; p<0·0001 for each comparison). After adjustment,
digoxin was associated with increased all-cause mortality (5·41 vs 4·30 events per
100 patients-years; hazard ratio 1·17; 95% CI 1·04-1·32; p=0·0093), vascular death
(3·55 vs 2·69 per 100 patient-years; 1·19; 1·03-1·39, p=0·0201), and sudden death
(1·68 vs 1·12 events per 100 patient-years; 1·36; 1·08-1·70, p=0·0076).
INTERPRETATION: Digoxin treatment was associated with a significant increase in
all-cause mortality, vascular death, and sudden death in patients with AF. This
association was independent of other measured prognostic factors, and although
residual confounding could account for these results, these data show the
possibility of digoxin having these effects. A randomised trial of digoxin in
treatment of AF patients with and without heart failure is needed. FUNDING: Janssen
Research & Development and Bayer HealthCare AG.
AD - Duke Heart Center, Duke University Medical Center, Durham, NC, USA.
Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
Mount Sinai Medical Center, New York, NY, USA.
Hospital of the University of Münster, Münster, Germany.
Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA.
Stanford School of Medicine, Stanford, CA, USA.
School of Medicine and Pharmacology, University of Western Australia, Perth, WA,
Australia.
Bayer HealthCare Pharmaceuticals, Whippany, NJ, USA.
Janssen Research & Development, Raritan, NJ, USA.
University of Edinburgh, and Royal Infirmary of Edinburgh, Edinburgh, UK.
Duke Translational Medicine Institute, Duke University Medical Center, Durham, NC,
USA.
Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA.
Electronic address: manesh.patel@duke.edu.
AN - 25749644
AU - Washam, J. B.
AU - Stevens, S. R.
AU - Lokhnygina, Y.
AU - Breithardt, G.
AU - Singer, D. E.
AU - Hankey, G. J.
AU - Berkowitz, S. D.
AU - Nessel, C. C.
AU - Fox, K. A.
AU - Califf, R. M.
AU - Piccini, J. P.
AU - Patel, M. R.
DA - Jun 13
DO - 10.1016/s0140-6736(14)61836-5
DP - NLM
ET - 2015/03/10
IS - 9985
KW - Aged
Anti-Arrhythmia Agents/administration & dosage/*adverse effects
Atrial Fibrillation/*drug therapy/*mortality
Death, Sudden/epidemiology
Digoxin/administration & dosage/*adverse effects
Female
Heart Rate
Humans
Intracranial Embolism/prevention & control
Male
Morpholines/therapeutic use
Rivaroxaban
Sex Distribution
Thiophenes/therapeutic use
LA - eng
N1 - 1474-547x
Washam, Jeffrey B
Stevens, Susanna R
Lokhnygina, Yuliya
Breithardt, Günter
Singer, Daniel E
Mahaffey, Kenneth W
Hankey, Graeme J
Berkowitz, Scott D
Nessel, Christopher C
Fox, Keith A A
Califf, Robert M
Piccini, Jonathan P
Patel, Manesh R
ROCKET AF Steering Committee and Investigators
Journal Article
England
Lancet. 2015 Jun 13;385(9985):2363-70. doi: 10.1016/S0140-6736(14)61836-5. Epub
2015 Mar 6.
PY - 2015
SN - 0140-6736
SP - 2363-70
ST - Digoxin use in patients with atrial fibrillation and adverse cardiovascular
outcomes: a retrospective analysis of the Rivaroxaban Once Daily Oral Direct Factor
Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and
Embolism Trial in Atrial Fibrillation (ROCKET AF)
T2 - Lancet
TI - Digoxin use in patients with atrial fibrillation and adverse cardiovascular
outcomes: a retrospective analysis of the Rivaroxaban Once Daily Oral Direct Factor
Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and
Embolism Trial in Atrial Fibrillation (ROCKET AF)
VL - 385
ID - 2867
ER -
TY - JOUR
AB - A case showing reinforcement of the action of warfarin and potassium in a
patient administered S-1 is reported.The patient was a 71-year-old man with left
upper gingival cancer.He had ventricular tachycardia (VT), hypertrophic
cardiomyopathy, and a cerebellar infarction.He underwent a pacemaker implantation,
and was administered warfarin.After the operation, in mid-March 2010, he was
administered with S-1 and warfarin. However, the international normalized ratio of
prothrombin time (PT-INR) increased to an extremely high level of 5.82, and S-1 and
warfarin were stopped. They were re-administered at the end of April, and the PT-
INR stabilized to approximately 2.
AD - Dept. of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University.
AN - 25596696
AU - Watanabe, H.
AU - Itoh, H.
AU - Tsuchiya, Y.
AU - Miyagi, N.
AU - Sugiyama, T.
AU - Nakai, Y.
AU - Shinozaki, Y.
AU - Noguchi, T.
AU - Jinbu, Y.
AU - Kusama, M.
DA - Jan
DP - NLM
ET - 2015/01/19
IS - 1
J2 - Gan to kagaku ryoho. Cancer & chemotherapy
KW - Aged
Antimetabolites, Antineoplastic/therapeutic use
Cardiomyopathy, Hypertrophic/complications/*drug therapy
Cerebral Infarction/complications/*drug therapy
Drug Combinations
Drug Interactions
Humans
Male
Mouth Neoplasms/complications/*drug therapy
Neoplasms, Squamous Cell/complications/*drug therapy
Oxonic Acid/therapeutic use
Tachycardia, Ventricular/complications/*drug therapy
Tegafur/therapeutic use
LA - jpn
N1 - Watanabe, Hideki
Itoh, Hiroto
Tsuchiya, Yoshiyuki
Miyagi, Norito
Sugiyama, Tomoko
Nakai, Yuichiro
Shinozaki, Yasuhisa
Noguchi, Tadahide
Jinbu, Yoshinori
Kusama, Mikio
Case Reports
English Abstract
Journal Article
Review
Japan
Gan To Kagaku Ryoho. 2015 Jan;42(1):131-3.
PY - 2015
SN - 0385-0684 (Print)
0385-0684
SP - 131-3
ST - [Reinforcement of warfarin action in a patient administered S-1]
T2 - Gan To Kagaku Ryoho
TI - [Reinforcement of warfarin action in a patient administered S-1]
VL - 42
ID - 2608
ER -
TY - JOUR
AB - BACKGROUND: Atrial fibrillation (AF) is associated with a high risk of
stroke. The contribution of arrhythmia to events is clear in sustained forms of AF,
but in paroxysmal AF, presently available data have yet to identify what proportion
of time spent in AF (ie, arrhythmia burden [AFB]) is of clinical relevance. We
aimed to assess this relationship using surrogate blood markers for the
hypercoagulable state associated with AF. METHODS: One hundred twenty-one
consecutive outpatients (mean age 74.7 +/- 7.8 years; 73 [60.3%] men) with
pacemakers capable of arrhythmia detection were recruited. AFB was assessed over a
1-month period and classified as AFB = 0%, 0.1% to 10%, 10.1% to 50%, or > 50%.
RESULTS: Baseline characteristics and comorbidities were comparable between groups.
There were no significant differences in levels of soluble E-selectin (sE-
selectin), von Willebrand factor (vWf), high-sensitivity C-reactive protein,
interleukin-6, soluble P-selectin (sP-selectin), or tissue factor (TF) across the
four patient groups. Levels of plasma brain natriuretic peptide (BNP) were
approximately twofold greater in the group with the highest AFB (P < .001).
Following a stepwise multiple linear regression analysis, age was a significant
predictor of vWf (P = .010), sP-selectin (P = .042), and BNP (P = .012). Left
ventricular fractional shortening was predictive of BNP (P = .001) and sE-selectin
(P = .012). Anticoagulation was a predictor of vWf levels (P = .005), and
hypertension was predictive of TF (P < .001). CONCLUSION: Given no appreciable
difference in levels of prothrombotic markers in relation to AFB in this study, it
is plausible that these abnormalities do, in fact, relate to underlying risk
factors, and that such patients should be anticoagulated if risk factors dictate.
Thus, AFB per se should probably not influence the decision to anticoagulate, but
rather the presence of AF combined with clinical risk scoring should remain the
predominant tool for stroke risk assessment.
Birmingham B18 7QH, England.
AN - 19858230
AU - Watson, T.
AU - Arya, A.
AU - Sulke, N.
AU - Lip, G. Y.
DA - Apr
DO - 10.1378/chest.09-1426
DP - NLM
ET - 2009/10/28
IS - 4
J2 - Chest
KW - Aged
Aged, 80 and over
Arrhythmias, Cardiac/*complications/therapy
Atrial Fibrillation/*complications/therapy
Biomarkers/blood
C-Reactive Protein/metabolism
Cohort Studies
E-Selectin/blood
Female
Humans
Inflammation/*blood
Interleukin-6/blood
Linear Models
Male
P-Selectin/blood
Risk Assessment
Risk Factors
Thrombosis/*blood
von Willebrand Factor/metabolism
LA - eng
N1 - 1931-3543
Watson, Timothy
Arya, Anita
Sulke, Neil
Lip, Gregory Y H
Journal Article
United States
Chest. 2010 Apr;137(4):869-76. doi: 10.1378/chest.09-1426. Epub 2009 Oct 26.
PY - 2010
SN - 0012-3692
SP - 869-76
ST - Relationship of indices of inflammation and thrombogenesis to arrhythmia
burden in paroxysmal atrial fibrillation
T2 - Chest
TI - Relationship of indices of inflammation and thrombogenesis to arrhythmia
burden in paroxysmal atrial fibrillation
VL - 137
ID - 2572
ER -
TY - JOUR
AB - The incidence of side effects of two contrast media containing different
amounts of sodium (Urografin 76 and Conray 70) is compared in two groups of
patients (totalling 133) under-going diagnostic examination by means of a cardiac
catheter and selective angiocardiography. The following results were obtained: 1.
Transient ischaemic reactions were observed in 4 patients of the Urografin group.
Cerebral circulation was temporarily restricted in 2 patients, but there were no
sequelae. One patient with a history of repeated cardiac infarction in whom the
examination was the last hope with a view to coronary surgery died immediately
after the angiocardiography. 2. In the Conray 70 group, ventricular fibrillation
occurred 32 times in 22 patients after a total of 155 injections. Protracted
asystole was observed in 2 patients. The explanation offered for the divergent
findings from the use of the two contrast media is not the different anions--the
iodine hosts--, but rather the difference in the amount of sodium contained in the
preparations. It is concluded from the studies that contrast media which deviate to
any great extent in their sodium content from the physiological range of the blood
sodium concentration are unsuitable for angiocardiography.
AN - 126925
AU - Weikl, A.
AU - Durst, O. E.
AU - Lang, E.
DA - Sep
DO - 10.1055/s-0029-1230184
DP - NLM
ET - 1975/09/01
IS - 3
J2 - RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der
Nuklearmedizin
KW - Angiocardiography/*adverse effects
Brain/blood supply
Diatrizoate/*adverse effects
Humans
Iothalamic Acid/*adverse effects
Ischemia/chemically induced
Middle Aged
Sodium/adverse effects
Structure-Activity Relationship
Ventricular Fibrillation/chemically induced
LA - ger
N1 - Weikl, A
Durst, O E
Lang, E
Comparative Study
English Abstract
Journal Article
Germany
Rofo. 1975 Sep;123(3):218-22. doi: 10.1055/s-0029-1230184.
OP - Komplikationen der selektiven Koronarangiographie in Abhängigkeit von
verwendeten Kontrastmitteln.
PY - 1975
SN - 1438-9029 (Print)
1438-9010
SP - 218-22
ST - [Complications of selective coronary angiography and the choice of contrast
media]
T2 - Rofo
TI - [Complications of selective coronary angiography and the choice of contrast
media]
VL - 123
ID - 2920
ER -
TY - JOUR
AB - BACKGROUND: There is increasing concern that prescription stimulants may be
associated with adverse cardiovascular events such as stroke, myocardial
infarction, and sudden death. Public health concerns are amplified by increasing
use of prescription stimulants among adults. METHODS: The objective of this study
was to conduct a systematic review of the evidence of an association between
prescription stimulant use and adverse cardiovascular outcomes. PUBMED, MEDLINE,
EMBASE and Google Scholar searches were conducted using key words related to these
topics (MESH): ADHD; Adults; Amphetamine; Amphetamines; Arrhythmias, Cardiac;
Cardiovascular Diseases; Cardiovascular System; Central Nervous Stimulants;
Cerebrovascular; Cohort Studies; Case-control Studies; Death; Death, Sudden,
Cardiac; Dextroamphetamine; Drug Toxicity; Methamphetamine; Methylphenidate;
Myocardial Infarction; Stimulant; Stroke; Safety. Eligible studies were population-
based studies of children, adolescents, or adults using prescription stimulant use
as the independent variable and a hard cardiovascular outcome as the dependent
variable. RESULTS: Ten population-based observational studies which evaluated
prescription stimulant use with cardiovascular outcomes were reviewed. Six out of
seven studies in children and adolescents did not show an association between
stimulant use and adverse cardiovascular outcomes. In contrast, two out of three
studies in adults found an association. CONCLUSIONS: Findings of an association
between prescription stimulant use and adverse cardiovascular outcomes are mixed.
Studies of children and adolescents suggest that statistical power is limited in
available study populations, and the absolute risk of an event is low. More
suggestive of a safety signal, studies of adults found an increased risk for
transient ischemic attack and sudden death/ventricular arrhythmia. Interpretation
was limited due to differences in population, cardiovascular outcome
selection/ascertainment, and methodology. Accounting for confounding and selection
biases in these studies is of particular concern. Future studies should address
this and other methodological issues.
AD - Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX, USA.
arthur.westover@utsouthwestern.edu
AN - 22682429
AU - Westover, A. N.
AU - Halm, E. A.
C2 - PMC3405448
DA - Jun 9
DO - 10.1186/1471-2261-12-41
DP - NLM
ET - 2012/06/12
KW - Adolescent
Adult
Amphetamines/*adverse effects
Attention Deficit Disorder with Hyperactivity/*drug therapy
Central Nervous System Stimulants/*adverse effects
Child
Death, Sudden, Cardiac/*epidemiology/etiology
Humans
Myocardial Infarction/*chemically induced
Prescription Drugs/adverse effects
Risk
Stroke/*chemically induced
LA - eng
N1 - 1471-2261
Westover, Arthur N
Halm, Ethan A
K08 DA031245/DA/NIDA NIH HHS/United States
Journal Article
Review
Systematic Review
BMC Cardiovasc Disord. 2012 Jun 9;12:41. doi: 10.1186/1471-2261-12-41.
PY - 2012
SN - 1471-2261
SP - 41
ST - Do prescription stimulants increase the risk of adverse cardiovascular
events?: A systematic review
TI - Do prescription stimulants increase the risk of adverse cardiovascular
events?: A systematic review
VL - 12
ID - 2950
ER -
TY - JOUR
AB - Neural control of the heart involves complex interconnections within the
central nervous system (CNS). Although various CNS abnormalities and processes
(acute cerebrovascular accidents, cerebral ischemia, subarachnoid hemorrhages, and
seizures) have been associated with alteration of cardiac electrophysiology, the
effect of +Gz-induced loss of consciousness (G-LOC) on autonomic control of the
heart is unknown. From a group of 59 healthy subjects undergoing centrifuge high
+Gz training, 15 suffered G-LOC episodes. The +Gz training profiles included
gradual (0.1 G/s) and rapid (approximately 6 G/s) exposures to levels as high as +9
Gz. Electrocardiographic rate and rhythm disturbances were evaluated during each of
the +Gz training profiles. Rate and rhythm disturbances associated with the +Gz
stress exposures were observed in 73% of the subjects. When considering only the
period when the subjects were exposed to +Gz (During-G), 67% of the individuals had
atrial or ventricular ectopy. When considering the period of unconsciousness
(During-LOC), which lasted an average of 12.6 s, 33% of the individuals had atrial
or ventricular ectopy. Electrocardiographic changes were related to +Gz stress and
unrelated to the period of occurrence of G-LOC. Significant ectopy (ventricular
tachycardia and supraventricular tachycardia) was observed only during +Gz stress
and not related to the G-LOC period. The results of the study do not indicate that
G-LOC alters the electrocardiographic response to +Gz stress.
AD - 72nd Aeromedical Evacuation Squadron (AFRES), McGuire AFB, NJ.
AN - 2386446
AU - Whinnery, A. M.
AU - Whinnery, J. E.
AU - Hickman, J. R.
DA - Jul
DP - NLM
ET - 1990/07/01
IS - 7
J2 - Aviation, space, and environmental medicine
KW - Adult
*Aerospace Medicine
Cardiovascular Physiological Phenomena
Central Nervous System/physiology
*Gravitation
Heart Rate
Humans
Military Personnel
Tachycardia/diagnosis/etiology
Time Factors
Unconsciousness/*etiology
LA - eng
N1 - Whinnery, A M
Whinnery, J E
Hickman, J R
Journal Article
United States
Aviat Space Environ Med. 1990 Jul;61(7):609-14.
PY - 1990
SN - 0095-6562 (Print)
0095-6562
SP - 609-14
ST - High +Gz centrifuge training: the electrocardiographic response to +Gz-
induced loss of consciousness
T2 - Aviat Space Environ Med
TI - High +Gz centrifuge training: the electrocardiographic response to +Gz-
induced loss of consciousness
VL - 61
ID - 2841
ER -
TY - JOUR
AB - BACKGROUND: Catheter ablation for ventricular tachycardia and premature
ventricular complexes (PVCs) is common. Catheter ablation of atrial fibrillation is
associated with a risk of cerebral emboli attributed to cardioversions and numerous
ablation lesions in the low-flow left atrium, but cerebral embolic risk in
ventricular ablation has not been evaluated. METHODS: We enrolled 18 consecutive
patients meeting study criteria scheduled for ventricular tachycardia or PVC
ablation over a 9-month period. Patients undergoing left ventricular (LV) ablation
were compared with a control group of those undergoing right ventricular ablation
only. Patients were excluded if they had implantable cardioverter defibrillators or
permanent pacemakers. Radiofrequency energy was used for ablation in all cases and
heparin was administered with goal-activated clotting times of 300 to 400 seconds
for all LV procedures. Pre- and postprocedural brain MRI was performed on each
patient within a week of the ablation procedure. Embolic infarcts were defined as
new foci of reduced diffusion and high signal intensity on fluid-attenuated
inversion recovery brain MRI within a vascular distribution. RESULTS: The mean age
was 58 years, half of the patients were men, half had a history of hypertension,
and the majority had no known vascular disease or heart failure. LV ablation was
performed in 12 patients (ventricular tachycardia, n=2; PVC, n=10) and right
ventricular ablation was performed exclusively in 6 patients (ventricular
tachycardia, n=1; PVC, n=5). Seven patients (58%) undergoing LV ablation
experienced a total of 16 cerebral emboli, in comparison with zero patients
undergoing right ventricular ablation (P=0.04). Seven of 11 patients (63%)
undergoing a retrograde approach to the LV developed at least 1 new brain lesion.
CONCLUSIONS: More than half of patients undergoing routine LV ablation procedures
(predominately PVC ablations) experienced new brain emboli after the procedure.
Future research is critical to understanding the long-term consequences of these
lesions and to determining optimal strategies to avoid them.
AD - From Electrophysiology Section, Division of Cardiology, University of
California, San Francisco (I.R.W., R.A.G., N.B., H.H.H., B.K.L., E.P.G., G.M.M.);
Department of Neurology, University of California, San Francisco (S.A.J., K.M.M.,
W.P.D., C.P.H.); and Division of Neuroradiology, Department of Radiology,
University of California, San Francisco (W.P.D., C.P.H.).
From Electrophysiology Section, Division of Cardiology, University of California,
San Francisco (I.R.W., R.A.G., N.B., H.H.H., B.K.L., E.P.G., G.M.M.); Department of
Neurology, University of California, San Francisco (S.A.J., K.M.M., W.P.D.,
C.P.H.); and Division of Neuroradiology, Department of Radiology, University of
California, San Francisco (W.P.D., C.P.H.). marcusg@medicine.ucsf.edu.
AN - 28119381
AU - Whitman, I. R.
AU - Gladstone, R. A.
AU - Badhwar, N.
AU - Hsia, H. H.
AU - Lee, B. K.
AU - Josephson, S. A.
AU - Meisel, K. M.
AU - Dillon, W. P., Jr.
AU - Hess, C. P.
AU - Gerstenfeld, E. P.
AU - Marcus, G. M.
DA - Feb 28
DP - NLM
ET - 2017/01/26
IS - 9
J2 - Circulation
KW - Aged
Aorta/diagnostic imaging
Brain/diagnostic imaging
Echocardiography
Female
Heart Ventricles/surgery
Humans
Intracranial Embolism/diagnostic imaging/*etiology
Male
Middle Aged
Ventricular Premature Complexes/*surgery
cardiac complexes, premature
catheter ablation
embolism
tachycardia, ventricular
LA - eng
N1 - 1524-4539
Whitman, Isaac R
Gladstone, Rachel A
Badhwar, Nitish
Hsia, Henry H
Lee, Byron K
Josephson, S Andrew
Meisel, Karl M
Dillon, William P Jr
Hess, Christopher P
Gerstenfeld, Edward P
Marcus, Gregory M
Journal Article
United States
Circulation. 2017 Feb 28;135(9):867-877. doi: 10.1161/CIRCULATIONAHA.116.025546.
Epub 2017 Jan 24.
PY - 2017
SN - 0009-7322
SP - 867-877
ST - Brain Emboli After Left Ventricular Endocardial Ablation
T2 - Circulation
TI - Brain Emboli After Left Ventricular Endocardial Ablation
VL - 135
ID - 2336
ER -
TY - JOUR
AB - INTRODUCTION: Left atrial catheter ablation of the pulmonary veins (PVs) is
an established option for patients with atrial fibrillation (AF). Asymptomatic
cerebral emboli (ACE) detected by diffusion weighted MRI (DW-MRI) following AF
ablation has been reported at varying rates. This variability may be linked to
procedural variables and demographic risk factors. Animal studies with the
multielectrode pulmonary vein ablation catheter (PVAC) have identified potential
sources of emboli, including air introduced during PVAC introduction, inadequate
anticoagulation, and high current densities when the distal (E1) and proximal (E10)
electrodes are in contact. We sought to evaluate the incidence, size, and number of
DW-MRI findings with procedural modifications that potentially reduce the embolic
load. METHODS: Thirty-seven AF patients (59 ± 10 years, 73% male, all with
paroxysmal AF, left atrial [LA] diameter 44 ± 7 mm, left ventricular ejection
fraction 57 ± 7%) underwent MRI sequences preceding ablation, within 24 hours
postablation, and at 4-6 weeks. During the procedure all patients were on
uninterrupted phenprocoumon, an attempted activated clotting time (ACT) level >300
seconds, had the PVAC introduced under saline, and antral ablation was started with
a 2:1 bipolar/unipolar mode. Files from the ablation unit (GENius v14.4) were
retrospectively analyzed to determine the relationship between E1 and E10 in close
proximity and DW-MRI findings. RESULTS: Post procedure, 10/37 patients (27%) were
positive for new DWI cerebral lesions. Nine of 10 patients had a single lesion, and
1/10 patient had 2 lesions. Average lesion size was 3.1 ± 3.9 mm (2-14 mm). One of
10 (10%) had lesions at MRI follow-up. No neurological symptoms were observed.
Eighteen of 37 (49%) of procedures had evidence of E1/E10 interaction. In the
subgroup of patients with and without E1 and E10 in close proximity, the DW-MRI
rate was 8/18 (44%) and 2/19 (11%), respectively (P = 0.029). CONCLUSIONS: The
source of positive DW-MRI findings in LA ablation involves several factors.
Controlling anticoagulation and careful sheath management helps to reduce the
number and size of DW-MRI lesions. With the PVAC catheter, an ablation with the E1
and E10 in close proximity increases the risk of a DW-MRI finding. In the future,
electrodes E1 and E10 should be kept apart to help reduce the incidence of acute
ACE.
AD - Department of Electrophysiology, Witten/Herdecke University, School of
Medicine, St. Agnes-Hospital, Bocholt, Germany. drmwieczorek@t-online.de
AN - 23134483
AU - Wieczorek, M.
AU - Lukat, M.
AU - Hoeltgen, R.
AU - Condie, C.
AU - Hilje, T.
AU - Missler, U.
AU - Hirsch, J.
AU - Scharf, C.
DA - Feb
DO - 10.1111/jce.12006
DP - NLM
ET - 2012/11/09
IS - 2
KW - Atrial Fibrillation/complications/*pathology/*surgery
Female
Humans
Intracranial Embolism/*etiology/*pathology
Male
Middle Aged
Pulmonary Artery/*pathology/*surgery
Treatment Outcome
LA - eng
N1 - 1540-8167
Wieczorek, Marcus
Lukat, Michael
Hoeltgen, Reinhard
Condie, Cathy
Hilje, Thomas
Missler, Ulrich
Hirsch, Jessica
Scharf, Christoph
Clinical Trial
Journal Article
United States
J Cardiovasc Electrophysiol. 2013 Feb;24(2):121-8. doi: 10.1111/jce.12006. Epub
2012 Nov 7.
PY - 2013
SN - 1045-3873
SP - 121-8
ST - Investigation into causes of abnormal cerebral MRI findings following PVAC
duty-cycled, phased RF ablation of atrial fibrillation
TI - Investigation into causes of abnormal cerebral MRI findings following PVAC
duty-cycled, phased RF ablation of atrial fibrillation
VL - 24
ID - 2903
ER -
TY - JOUR
AB - PURPOSE: To report a rare case of isolated, unilateral CRAO in a young
patient with mitral valve prolapse secondary to Barlow's disease. OBSERVATIONS: A
29-year-old woman with history of premature ventricular contractions and cardiac
ablation presented to the emergency room after sudden onset painless visual loss in
her left eye (OS). Her vision was 20/20 in her right eye and hand motion in the
left. Fundus exam demonstrated a central retinal artery occlusion (CRAO) OS.
Computerized tomography of head and neck were unremarkable. She underwent cerebral
angiogram and local intra-arterial thrombolysis. Her vision remained stable post-
procedure, with marked APD and stable fundus examination. Her cardiac work-up
revealed a left atrial mass with calcified mitral valve, and small atrial septal
defect. Rheumatologic, hematologic, and auto-immune work-up were unremarkable. She
underwent resection of the mass with repair of mitral valve and ASD closure.
Surgical pathology was compatible with diagnosis of Barlow's disease, a cause of
mitral valve prolapse. The patient underwent intravitreal injection of anti-VEGF
therapy at one month follow-up, with vision stable at hand motion and without
neovascularization on subsequent evaluation. CONCLUSIONS: In young patients
presenting with CRAO, aggressive work-up for systemic disease or embolic source
must be undertaken to avoid future sequelae.
AD - Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, One
Gustave L. Levy Place, New York, NY 10029, USA.
Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, 310
East 14th Street, New York, NY 10003, USA.
AN - 29780944
AU - Wilkins, C. S.
AU - McCabe, K.
AU - Deobhakta, A.
AU - Chelnis, J.
C2 - PMC5956717
DA - Jun
DO - 10.1016/j.ajoc.2018.03.003
DP - NLM
ET - 2018/05/22
J2 - American journal of ophthalmology case reports
KW - Barlow's disease
Central retinal artery occlusion
Intra-arterial thrombolysis
Mitral valve prolapse
Tissue plasminogen activator
tPA
LA - eng
N1 - 2451-9936
Wilkins, Carl S
McCabe, Katherine
Deobhakta, Avnish
Chelnis, James
Case Reports
Am J Ophthalmol Case Rep. 2018 Mar 8;10:249-252. doi: 10.1016/j.ajoc.2018.03.003.
eCollection 2018 Jun.
PY - 2018
SN - 2451-9936
SP - 249-252
ST - Central retinal artery occlusion secondary to Barlow's disease
T2 - Am J Ophthalmol Case Rep
TI - Central retinal artery occlusion secondary to Barlow's disease
VL - 10
ID - 3144
ER -
TY - JOUR
AD - Cleveland Clinic, Cleveland, Ohio.
Centre Hospitalier Universitaire Trousseau, Tours, France.
Waikato Hospital, Hamilton, New Zealand.
Department of Medicine, Cardiology Division, McMaster University-Population Health
Research Institute, Hamilton, Canada.
Duke University Medical Center, Durham, North Carolina.
Grupo HM Hospitales, Universidad CEU San Pablo, Madrid, Spain.
Centro Privado De Cardiologia, Tucuman, Argentina.
Johns Hopkins University, Baltimore, Maryland.
Servicio de Arritmias, Instituto de Cardiologia Infantil, Montevideo, Uruguay.
Clinica y Maternidad Suizo Argentina; De Los Arcos Sanatorio, Buenos Aires,
Argentina.
Virginia Commonwealth University Medical Center, Richmond, VA.
New England Medical Center, Boston, Massachusetts.
Federal University of Sªo Paulo, Sªo Paulo, Brazil.
Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Humanitas Research Hospital, Milan, Italy.
William Beaumont Hospital Division of Cardiology, Royal Oak, Michigan.
North Texas Heart Center, Dallas, Texas.
Hospital Privado del Sur, Bahia Blanca, Argentina.
Deutsches Herzzentrum Munchen, Munich, Germany.
Allgemeines Krankenhaus St. Georg, Hamburg, Germany.
Vilnius University, Clinic of Cardiac and Vascular Diseases, Lithuania.
Instituto do Coraçªo, Universidade de Sªo Paulo, Sªo Paulo, Brazil.
Royal Prince Alfred Hospital, Sydney, Australia.
Mexico's National University, Mexico's General Hospital, Mexico City, Mexico.
Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan.
Azienda Ospedaliero Universitaria S. Maria della Misericordia- Udine, Udine, Italy.
Cooper University Hospital, Camden, New Jersey.
Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Cedars-Sinai Medical Center, Beverly Hills, California.
National Heart Centre Singapore, Singapore, Singapore.
CES Cardiología and Centros Especializados San Vicente Fundación, Medellín y
Rionegro, Colombia.
Tel Aviv Sourasky Medical Center and Sackler School of Medicine, Tel Aviv
University, Tel Aviv, Israel.
Chang Gung Memorial Hospital, Taipei, Taiwan.
National Center for Cardiovascular Disease and Beijing Fu Wai Hospital, Peking
Union Medical College and China Academy of Medical Sciences, Beijing, China.
AN - 26949427
AU - Wilkoff, B. L.
AU - Fauchier, L.
AU - Stiles, M. K.
AU - Morillo, C. A.
AU - Al-Khatib, S. M.
AU - Almendral, J.
AU - Aguinaga, L.
AU - Berger, R. D.
AU - Cuesta, A.
AU - Daubert, J. P.
AU - Dubner, S.
AU - Ellenbogen, K. A.
AU - Estes, N. A., 3rd
AU - Fenelon, G.
AU - Garcia, F. C.
AU - Gasparini, M.
AU - Haines, D. E.
AU - Healey, J. S.
AU - Hurtwitz, J. L.
AU - Keegan, R.
AU - Kolb, C.
AU - Kuck, K. H.
AU - Marinskis, G.
AU - Martinelli, M.
AU - McGuire, M.
AU - Molina, L. G.
AU - Okumura, K.
AU - Proclemer, A.
AU - Russo, A. M.
AU - Singh, J. P.
AU - Swerdlow, C. D.
AU - Teo, W. S.
AU - Uribe, W.
AU - Viskin, S.
AU - Wang, C. C.
AU - Zhang, S.
C2 - PMC4759125
DA - Feb
DO - 10.1016/j.joa.2015.12.001
DP - NLM
ET - 2016/03/08
IS - 1
KW - AF, atrial fibrillation
ATP, antitachycardia pacing
Bradycardia mode and rate
CI, confidence interval
CL, cycle length
CRT, cardiac resynchronization therapy
CRT-D, cardiac resynchronization therapy–defibrillator
DT, defibrillation testing
Defibrillation testing
EEG, electroencephalography
EGM, electrogram
HF, heart failure
HR, hazard ratio
ICD, implantable cardioverter-defibrillator
Implantable cardioverter-defibrillator
LV, left ventricle
LVEF, left ventricular ejection fraction
MI, myocardial infarction
MVP, managed ventricular pacing
NCDR, National Cardiovascular Data Registry
NYHA, New York Heart Association
OR, odds ratio
PEA, peak endocardial acceleration
PVC, premature ventricular contraction
Programming
RCT, randomized clinical trial
RV, right ventricle
S-ICD, subcutaneous implantable cardioverter-defibrillator
SCD, sudden cardiac death
SVT, supraventricular tachycardia
TIA, transient ischemic attack
Tachycardia detection
Tachycardia therapy
VF, ventricular fibrillation
VT, ventricular tachycardia (Heart Rhythm 2015
0:1–37)
aCRT, adaptive cardiac resynchronization therapy
LA - eng
N1 - 1883-2148
Wilkoff, Bruce L
Fauchier, Laurent
Stiles, Martin K
Morillo, Carlos A
Al-Khatib, Sana M
Almendral, Jesœs
Aguinaga, Luis
Berger, Ronald D
Cuesta, Alejandro
Daubert, James P
Dubner, Sergio
Ellenbogen, Kenneth A
Estes, N A Mark 3rd
Fenelon, Guilherme
Garcia, Fermin C
Gasparini, Maurizio
Haines, David E
Healey, Jeff S
Hurtwitz, Jodie L
Keegan, Roberto
Kolb, Christof
Kuck, Karl-Heinz
Marinskis, Germanas
Martinelli, Martino
McGuire, Mark
Molina, Luis G
Okumura, Ken
Proclemer, Alessandro
Russo, Andrea M
Singh, Jagmeet P
Swerdlow, Charles D
Teo, Wee Siong
Uribe, William
Viskin, Sami
Wang, Chun-Chieh
Zhang, Shu
Journal Article
J Arrhythm. 2016 Feb;32(1):1-28. doi: 10.1016/j.joa.2015.12.001. Epub 2016 Feb 1.
PY - 2016
SN - 1880-4276 (Print)
1880-4276
SP - 1-28
ST - 2015 HRS/EHRA/APHRS/SOLAECE expert consensus statement on optimal implantable
cardioverter-defibrillator programming and testing
T2 - J Arrhythm
TI - 2015 HRS/EHRA/APHRS/SOLAECE expert consensus statement on optimal implantable
cardioverter-defibrillator programming and testing
VL - 32
ID - 3092
ER -
TY - JOUR
AB - OBJECTIVES: To evaluate the cardiac safety of central nervous system
stimulants in children and adolescents. DESIGN: Population based retrospective
cohort study. SETTING: Automated healthcare claims data from 1,219,847 children and
young people eligible for 28 state Medicaid programmes from 1999 to 2006 linked to
the Social Security Death Master File and the National Death Index. PARTICIPANTS:
Children and young people age 3-18 entered the cohort at the first diagnosis of a
mental health condition commonly treated with stimulants (such as attention-
deficit/hyperactivity disorder) after a minimum period of six months' eligibility
and were followed until loss of eligibility, their 19th birthday, admission to
hospital for longer than 30 days, or death. Exclusion criteria included transplant
recipients, receipt of dialysis, or claims indicating substance misuse. We retained
high risk groups with similar use of stimulants as low risk children (such as
children with congenital heart disease). Sociodemographic characteristics, cardiac
risk factors, and psychiatric diagnoses obtained from before the index period were
summarised with a propensity score. We used discrete survival analysis to estimate
the relative risk for periods of stimulant use and non-use, adjusted for propensity
score and antipsychotic use for the full cohort and the high risk and low risk
groups. MAIN OUTCOME MEASURES: Composite endpoint of stroke, acute myocardial
infarction, or sudden cardiac death; a secondary composite endpoint added
ventricular arrhythmia RESULTS: A total of 66 (95 including ventricular arrhythmia)
events occurred during 2,321,311 years of follow-up. The odds ratio adjusted for
propensity score and antipsychotic use for current versus no stimulant use was 0.62
(95% confidence interval 0.27 to 1.44), with a corresponding adjusted incidence
rate of 2.2 and 3.5 per 100,000 patient years for current stimulant and non-use,
respectively. Twenty six events occurred in high risk patients (incidence rate 63
per 100,000 patient years) with an odds ratio of 1.02 (0.28 to 3.69). Odds ratios
for the secondary endpoint were similar to those for the primary endpoint (0.74,
0.38 to 1.46). CONCLUSIONS: Treatment of children with central nervous stimulants
is not significantly associated with an increase in the short term risk of severe
cardiac events. Analyses cannot be generalised to children with long term use of
stimulants. Furthermore, long term effects of slight increases in heart rate or
blood pressure are unknown.
AD - Pharmaceutical Outcomes and Policy, College of Pharmacy, Epidemiology,
Colleges of Medicine and Public Health and Health Professions, University of
Florida, Gainesville, Florida 32611, USA. almut@cop.ufl.edu
AN - 22809800
AU - Winterstein, A. G.
AU - Gerhard, T.
AU - Kubilis, P.
AU - Saidi, A.
AU - Linden, S.
AU - Crystal, S.
AU - Zito, J.
AU - Shuster, J. J.
AU - Olfson, M.
C2 - PMC3399772 www.icmje.org/coi_disclosure.pdf (available on request from the
corresponding author) and declare that MO has received funding from the National
Institute for Mental Health for a related topic.
DA - Jul 18
DO - 10.1136/bmj.e4627
DP - NLM
ET - 2012/07/20
J2 - BMJ (Clinical research ed.)
KW - Adolescent
Antipsychotic Agents/therapeutic use
Attention Deficit Disorder with Hyperactivity/*drug therapy
Central Nervous System Stimulants/adverse effects/*therapeutic use
Child
Child, Preschool
Female
Heart Diseases/*epidemiology
Humans
Male
Medicaid
LA - eng
N1 - 1756-1833
Winterstein, Almut G
Gerhard, Tobias
Kubilis, Paul
Saidi, Arwa
Linden, Stephan
Crystal, Stephen
Zito, Julie
Shuster, Jonathan J
Olfson, Mark
R01 HS018506/HS/AHRQ HHS/United States
1UL1 TR000064/TR/NCATS NIH HHS/United States
R01-HS0185606/HS/AHRQ HHS/United States
Journal Article
BMJ. 2012 Jul 18;345:e4627. doi: 10.1136/bmj.e4627.
PY - 2012
SN - 0959-8138 (Print)
0959-8138
SP - e4627
ST - Cardiovascular safety of central nervous system stimulants in children and
adolescents: population based cohort study
T2 - Bmj
TI - Cardiovascular safety of central nervous system stimulants in children and
adolescents: population based cohort study
VL - 345
ID - 2866
ER -
TY - JOUR
AB - OBJECTIVE: Mild therapeutic hypothermia (MTH) has been integrated into
international resuscitation guidelines. In the majority of patients, sudden cardiac
arrest is caused by myocardial infarction. This study investigated whether a
combination of MTH with primary percutaneous coronary intervention (PCI) is
feasible, safe, and potentially beneficial in patients after cardiac arrest due to
acute myocardial infarction. DESIGN: Single-center observational study with a
historical control group. SETTING: University clinic. PATIENTS: Thirty-three
patients after cardiac arrest with ventricular fibrillation as initial rhythm and
restoration of spontaneous circulation who remained unconscious at admission and
presented with acute ST elevation myocardial infarction (STEMI). INTERVENTIONS: In
16 consecutive patients (2005-2006), MTH was initiated immediately after admission
and continued during primary PCI. Seventeen consecutive patients who were treated
in a similar 2-yr observation interval before implementation of MTH (2003-2004)
served as a control group. Feasibility, safety, mortality, and neurologic outcome
were documented. MEASUREMENTS AND MAIN RESULTS: Initiation of MTH did not result in
longer door-to-balloon times compared with the control group (82 vs. 85 mins),
indicating that implementation of MTH did not delay the onset of primary PCI.
Target temperature (32-34 degrees C) in the MTH group was reached within 4 hrs,
consistent with previous trials and suggesting that primary PCI did not affect the
velocity of cooling. Despite a tendency to increased bleeding complications and
infections, patients treated with MTH tended to have a lower mortality after 6
months (25% vs. 35%, p = .71) and an improved neurologic outcome as determined by a
Glasgow-Pittsburgh Cerebral Performance Scale score of 1 or 2 (69% vs. 47% in the
control group, p = .30). CONCLUSIONS: MTH in combination with primary PCI is
feasible and safe in patients resuscitated after cardiac arrest due to acute
myocardial infarction. A combination of these therapeutic procedures should be
strongly considered as standard therapy in patients after out-of-hospital cardiac
arrest due to STEMI.
AD - Medical Clinic II, University of Schleswig-Holstein, Campus Lübeck, Lübeck,
Germany. sebastian.wolfrum@uk-sh.de
AN - 18496378
AU - Wolfrum, S.
AU - Pierau, C.
AU - Radke, P. W.
AU - Schunkert, H.
AU - Kurowski, V.
DA - Jun
DO - 10.1097/CCM.0b013e31817437ca
DP - NLM
ET - 2008/05/23
IS - 6
J2 - Critical care medicine
KW - Aged
Cardiopulmonary Resuscitation/*methods
Critical Pathways
*Emergency Medical Services
Feasibility Studies
Female
Follow-Up Studies
Germany
Heart Arrest/mortality/*therapy
Humans
Hypothermia, Induced/*methods
Intensive Care Units/statistics & numerical data
Male
Middle Aged
Myocardial Infarction/mortality/*therapy
Outcome and Process Assessment, Health Care
Prospective Studies
Survival Rate
Time and Motion Studies
Ventricular Fibrillation/mortality/therapy
LA - eng
N1 - 1530-0293
Wolfrum, Sebastian
Pierau, Christian
Radke, Peter W
Schunkert, Heribert
Kurowski, Volkhard
Journal Article
United States
Crit Care Med. 2008 Jun;36(6):1780-6. doi: 10.1097/CCM.0b013e31817437ca.
PY - 2008
SN - 0090-3493
SP - 1780-6
ST - Mild therapeutic hypothermia in patients after out-of-hospital cardiac arrest
due to acute ST-segment elevation myocardial infarction undergoing immediate
T2 - Crit Care Med
TI - Mild therapeutic hypothermia in patients after out-of-hospital cardiac arrest
due to acute ST-segment elevation myocardial infarction undergoing immediate
VL - 36
ID - 3008
ER -
TY - JOUR
AB - OBJECTIVES: To find out what spectrum of cardiac abnormalities are found in
those stroke survivors who can be deemed to be at high cardiac risk by their having
long QT. METHODS: 202 patients with good recovery from a cerebrovascular event
occurring at least one month previously were recruited into a prospective
epidemiological study. These stroke survivors underwent a battery of cardiac
investigations including 12 lead ECG, echocardiography, myocardial perfusion
scanning, and heart rate variability assessment. The ECGs were digitised by a
single observer blinded to the blood pressure and other investigations of the
patients. The maximum heart rate corrected QT interval (QTc max) in the 12 lead ECG
was derived by Bazett's formula. RESULTS: Prolonged QTc max significantly
correlated with increasing blood pressure, left ventricular mass index, and
depressed heart rate variability. As the number of cardiac abnormalities increased,
QTc max became more prolonged. CONCLUSIONS: Long QT is significantly associated
with left ventricular mass index even after adjustment for both systolic and
diastolic blood pressures. Long QT was also associated with the total cardiac
disease burden. These two observations may explain why stroke survivors with long
QTc max were at greater risk of cardiac death.
AD - Division of Medicine and Therapeutics, University of Dundee, Dundee, UK.
kywong@doctors.org.uk
AN - 16162622
AU - Wong, K. Y.
AU - McSwiggan, S.
AU - Kennedy, N. S.
AU - Wong, S. Y.
AU - Gavin, A.
AU - MacWalter, R. S.
AU - Struthers, A. D.
C2 - PMC1769139
DA - Oct
DO - 10.1136/hrt.2004.045187
DP - NLM
ET - 2005/09/16
IS - 10
KW - Adult
Aged
Aged, 80 and over
Blood Pressure
Cardiomyopathies/*complications
Electrocardiography
Female
Humans
Long QT Syndrome/*etiology
Male
Middle Aged
Prospective Studies
Single-Blind Method
Stroke/*etiology
LA - eng
N1 - 1468-201x
Wong, K Y K
McSwiggan, S
Kennedy, N S J
Wong, S Y S
Gavin, A
MacWalter, R S
Struthers, A D
Journal Article
Heart. 2005 Oct;91(10):1306-10. doi: 10.1136/hrt.2004.045187.
PY - 2005
SN - 1355-6037 (Print)
1355-6037
SP - 1306-10
ST - Spectrum of cardiac abnormalities associated with long QT in stroke survivors
T2 - Heart
TI - Spectrum of cardiac abnormalities associated with long QT in stroke survivors
VL - 91
ID - 2587
ER -
TY - JOUR
AN - 20167909
AU - Worthington, J. M.
AU - Gattellari, M.
AU - Leung, D. Y.
DA - Apr
DO - 10.1161/strokeaha.109.574426
DP - NLM
ET - 2010/02/20
IS - 4
J2 - Stroke
KW - Atrial Fibrillation/physiopathology
Cohort Studies
Electrocardiography
Female
Humans
Male
Middle Aged
Risk Factors
Ventricular Premature Complexes/*complications/physiopathology
LA - eng
N1 - 1524-4628
Worthington, John M
Gattellari, Melina
Leung, Dominic Y
Comment
Editorial
United States
PY - 2010
SN - 0039-2499
SP - 572-3
ST - 'Where there's smoke ...': are premature ventricular complexes a new risk
factor for stroke?
T2 - Stroke
TI - 'Where there's smoke ...': are premature ventricular complexes a new risk
factor for stroke?
VL - 41
ID - 2741
ER -
TY - JOUR
AB - BACKGROUND: Atrial fibrillation (AF) is a risk factor for development of
thromboembolic events with an annual stroke rate of 4.5%. In subjects over 80 years
AF is the single leading cause of major stroke. Moreover, about 25% of patients
with AF in the absence of neurological deficits have tomographic signs of one or
more silent cerebral infarcts. AIM: To investigate whether cognitive function in
patients with permanent AF is significantly worse than in patients with sinus
rhythm. METHODS: We included subjects aged > 65 years, without previous
cerebrovascular events or dementia, with permanent arrhythmia lasting > 12 months.
The AF group comprised 51 patients, aged 75.8 years. The control group consisted of
43 patients with sinus rhythm. The main points of the study protocol were: clinical
history recording, physical examination, biochemical analyses, standard 12-lead ECG
and transthoracic echocardiography. Cognitive status was assessed by Mini Mental
State Examination (MMSE). RESULTS: Patients had established AF with a median
duration of 4.9 years (range 1-21 years). Of the 51 patients, 51% had hypertension,
37% coronary artery disease, 12% presented sick sinus syndrome or atrioventricular
advanced block with a VVI pacemaker implanted. There were no significant
differences between the two groups though AF patients presented left ventricular
hypertrophy and history of myocardial infarction more frequently. Patients in the
sinus group had a lower-risk profile and received antithrombotic therapy less
frequently than the AF group. However, a significant proportion of patients,
particularly in the AF group received less than optimal thromboembolic prophylactic
treatment with anticoagulants. Cognitive status was found to be significantly lower
in the AF group, compared with the sinus rhythm group: 24.8 +/- 3.1 vs. 27.1 +/-
2.6 (p < 0.05). There were 43% patients with cognitive impairment in the AF group
and 14% in the sinus rhythm group. CONCLUSIONS: Permanent AF in patients aged over
65 years seems to be associated with lower MMSE score compared with subjects with
sinus rhythm. Cognitive impairment in older patients is a multifactorial disorder.
One of the causes of low cognitive function in these patients appears to be
permanent AF. Further prospective clinical trials should help determine the
possible role of inadequate anticoagulant treatment, and its association with the
deterioration of cognitive function in AF patients.
AD - 1st Department of Cardiology, Centre of Cardiology, 25-736 Kielce, Poland.
bw.kaplon@poczta.onet.pl
AN - 19521933
AU - Wozakowska-Kapłon, B.
AU - Opolski, G.
AU - Kosior, D.
AU - Jaskulska-Niedziela, E.
AU - Maroszyńska-Dmoch, E.
AU - Włosowicz, M.
DA - May
DP - NLM
ET - 2009/06/13
IS - 5
KW - Aged
Aged, 80 and over
Chronic Disease
Cognition Disorders/diagnosis/*etiology
Female
Humans
Male
Prospective Studies
LA - eng
N1 - Wozakowska-Kapłon, Beata
Opolski, Grzegorz
Kosior, Dariusz
Jaskulska-Niedziela, Elzbieta
Maroszyńska-Dmoch, Ewa
Włosowicz, Monika
Journal Article
Poland
Kardiol Pol. 2009 May;67(5):487-93.
PY - 2009
SN - 0022-9032 (Print)
0022-9032
SP - 487-93
ST - Cognitive disorders in elderly patients with permanent atrial fibrillation
T2 - Kardiol Pol
TI - Cognitive disorders in elderly patients with permanent atrial fibrillation
VL - 67
ID - 2975
ER -
TY - JOUR
AB - BACKGROUND: No simplified bedside risk scores have been created to predict
long-term mortality after coronary artery bypass graft surgery. METHODS AND
RESULTS: The New York State Cardiac Surgery Reporting System was used to identify
8597 patients who underwent isolated coronary artery bypass graft surgery in July
through December 2000. The National Death Index was used to ascertain patients'
vital statuses through December 31, 2007. A Cox proportional hazards model was fit
to predict death after CABG surgery using preprocedural risk factors. Then, points
were assigned to significant predictors of death on the basis of the values of
their regression coefficients. For each possible point total, the predicted risks
of death at years 1, 3, 5, and 7 were calculated. It was found that the 7-year
mortality rate was 24.2 in the study population. Significant predictors of death
included age, body mass index, ejection fraction, unstable hemodynamic state or
shock, left main coronary artery disease, cerebrovascular disease, peripheral
arterial disease, congestive heart failure, malignant ventricular arrhythmia,
chronic obstructive pulmonary disease, diabetes mellitus, renal failure, and
history of open heart surgery. The points assigned to these risk factors ranged
from 1 to 7; possible point totals for each patient ranged from 0 to 28. The
observed and predicted risks of death at years 1, 3, 5, and 7 across patient groups
stratified by point totals were highly correlated. CONCLUSION: The simplified risk
score accurately predicted the risk of mortality after coronary artery bypass graft
surgery and can be used for informed consent and as an aid in determining treatment
choice.
AD - Department of Public Health Sciences, Penn State Hershey College of Medicine,
Academic Support Bldg, Ste 2200, A210, 600 Centerview Dr, ASB 2200, Hershey, PA
17033, USA. chuntao.wu@psu.edu
AN - 22547673
AU - Wu, C.
AU - Camacho, F. T.
AU - Wechsler, A. S.
AU - Lahey, S.
AU - Culliford, A. T.
AU - Jordan, D.
AU - Gold, J. P.
AU - Higgins, R. S.
AU - Smith, C. R.
AU - Hannan, E. L.
C2 - PMC3422677
C6 - NIHMS385450
DA - May 22
DP - NLM
ET - 2012/05/02
IS - 20
J2 - Circulation
KW - Aged
Aged, 80 and over
Coronary Artery Bypass/*mortality
Coronary Disease/*mortality/*surgery
Databases, Factual/statistics & numerical data
Female
Follow-Up Studies
Humans
Male
Middle Aged
Risk Factors
LA - eng
N1 - 1524-4539
Wu, Chuntao
Camacho, Fabian T
Wechsler, Andrew S
Lahey, Stephen
Culliford, Alfred T
Jordan, Desmond
Gold, Jeffrey P
Higgins, Robert S D
Smith, Craig R
Hannan, Edward L
RC1 HL099122/HL/NHLBI NIH HHS/United States
RC1HL099122/HL/NHLBI NIH HHS/United States
Journal Article
Circulation. 2012 May 22;125(20):2423-30. doi: 10.1161/CIRCULATIONAHA.111.055939.
Epub 2012 Apr 30.
PY - 2012
SN - 0009-7322 (Print)
0009-7322
SP - 2423-30
ST - Risk score for predicting long-term mortality after coronary artery bypass
graft surgery
T2 - Circulation
TI - Risk score for predicting long-term mortality after coronary artery bypass
graft surgery
VL - 125
ID - 3138
ER -
TY - JOUR
AB - OBJECTIVE: The aim of this study was to investigate the effect of different
treatment interventions on plasma N-terminal fragment of the prohormone brain
natriuretic peptide (NT-proBNP) levels and early exercise tolerance in patients
with acute ST-segment elevation myocardial infarction. METHODS: 146 consecutive
patients with ST-segment elevation myocardial infarction who received emergency
percutaneous coronary intervention (PCI) (n = 55), elective PCI (n = 47), or drug
treatment (n = 44) were included. Plasma NT-proBNP levels and left ventricular
ejection fractions (LVEFs) were measured before the treatment intervention and at 1
week and 1 month afterward. An exercise stress test was performed 1 month after the
intervention, and the occurrences of major adverse cardiac events (MACE) were
recorded at the 1-month follow-up. RESULTS: Compared with the elective PCI and drug
treatment groups, at 1 week and 1 month after the intervention, the emergency PCI
group's plasma NT-proBNP levels were significantly lower, and the group's LVEFs
were significantly higher (all P < 0.05). There was a significantly negative
correlation between plasma NT-proBNP levels and LVEFs in each group (all P < 0.05).
The positive exercise stress testing rates were 13.0%, 32.6%, and 38.6% in the
emergency PCI, elective PCI, and drug treatment groups, respectively (P < 0.05).
The occurrences of MACE in the emergency PCI, elective PCI, and drug treatment
groups were 34.5%, 59.5%, and 65.9%, respectively (P < 0.05). CONCLUSION: Emergency
PCI resulted in lower plasma NT-proBNP levels, lower MACE incidence, higher LVEFs,
and better early exercise tolerance compared with elective PCI or drug treatment,
indicating that lower plasma NT-proBNP levels predicted a better prognosis.
AD - Department of Cardiology, Xiangyang Central Hospital, Xiangyang, Hubei
Province, China. wxling.23@163.com
AN - 22437216
AU - Wu, X. L.
AU - Zhu, R.
AU - Jiang, H.
AU - Li, B.
DA - Mar
DO - 10.3810/pgm.2012.03.2537
DP - NLM
ET - 2012/03/23
IS - 2
J2 - Postgraduate medicine
KW - Adult
Aged
*Angioplasty
Biomarkers/blood
Cardiovascular Agents/pharmacology/*therapeutic use
Exercise Test
*Exercise Tolerance/drug effects
Female
Follow-Up Studies
Humans
Male
Middle Aged
Myocardial Infarction/blood/complications/mortality/*therapy
Treatment Outcome
LA - eng
N1 - 1941-9260
Wu, Xiao-lin
Zhu, Rui
Jiang, Hong
Li, Bin
Clinical Trial
Comparative Study
Journal Article
England
Postgrad Med. 2012 Mar;124(2):58-63. doi: 10.3810/pgm.2012.03.2537.
PY - 2012
SN - 0032-5481
SP - 58-63
ST - Different treatment interventions affect plasma NT-ProBNP levels and early
exercise tolerance in patients with acute ST-segment elevation myocardial
infarction
T2 - Postgrad Med
TI - Different treatment interventions affect plasma NT-ProBNP levels and early
exercise tolerance in patients with acute ST-segment elevation myocardial
infarction
VL - 124
ID - 3029
ER -
TY - JOUR
AB - BACKGROUND: There are two approaches to the treatment of atrial fibrillation:
one is cardioversion and treatment with antiarrhythmic drugs to maintain sinus
rhythm, and the other is the use of rate-controlling drugs, allowing atrial
fibrillation to persist. In both approaches, the use of anticoagulant drugs is
recommended. METHODS: We conducted a randomized, multicenter comparison of these
two treatment strategies in patients with atrial fibrillation and a high risk of
stroke or death. The primary end point was overall mortality. RESULTS: A total of
4060 patients (mean [+/-SD] age, 69.7+/-9.0 years) were enrolled in the study; 70.8
percent had a history of hypertension, and 38.2 percent had coronary artery
disease. Of the 3311 patients with echocardiograms, the left atrium was enlarged in
64.7 percent and left ventricular function was depressed in 26.0 percent. There
were 356 deaths among the patients assigned to rhythm-control therapy and 310
deaths among those assigned to rate-control therapy (mortality at five years, 23.8
percent and 21.3 percent, respectively; hazard ratio, 1.15 [95 percent confidence
interval, 0.99 to 1.34]; P=0.08). More patients in the rhythm-control group than in
the rate-control group were hospitalized, and there were more adverse drug effects
in the rhythm-control group as well. In both groups, the majority of strokes
occurred after warfarin had been stopped or when the international normalized ratio
was subtherapeutic. CONCLUSIONS: Management of atrial fibrillation with the rhythm-
control strategy offers no survival advantage over the rate-control strategy, and
there are potential advantages, such as a lower risk of adverse drug effects, with
the rate-control strategy. Anticoagulation should be continued in this group of
high-risk patients.
AD - AFFIRM Clinical Trial Center, Axio Research, 2601 4th Ave., Ste. 200,
Seattle, WA 98121, USA.
AN - 12466506
AU - Wyse, D. G.
AU - Waldo, A. L.
AU - DiMarco, J. P.
AU - Domanski, M. J.
AU - Rosenberg, Y.
AU - Schron, E. B.
AU - Kellen, J. C.
AU - Greene, H. L.
AU - Mickel, M. C.
AU - Dalquist, J. E.
AU - Corley, S. D.
DA - Dec 5
DO - 10.1056/NEJMoa021328
DP - NLM
ET - 2002/12/06
IS - 23
Aged
Anti-Arrhythmia Agents/adverse effects/*therapeutic use
Catheter Ablation
Cross-Over Studies
Female
Heart Rate
Humans
Male
Stroke/etiology
Survival Analysis
LA - eng
N1 - 1533-4406
Wyse, D G
Waldo, A L
DiMarco, J P
Domanski, M J
Rosenberg, Y
Schron, E B
Kellen, J C
Greene, H L
Mickel, M C
Dalquist, J E
Corley, S D
Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM)
Investigators
Clinical Trial
Comparative Study
Journal Article
Multicenter Study
United States
N Engl J Med. 2002 Dec 5;347(23):1825-33. doi: 10.1056/NEJMoa021328.
PY - 2002
SN - 0028-4793
SP - 1825-33
ST - A comparison of rate control and rhythm control in patients with atrial
fibrillation
T2 - N Engl J Med
TI - A comparison of rate control and rhythm control in patients with atrial
fibrillation
VL - 347
ID - 2286
ER -
TY - JOUR
AB - BACKGROUND: Obstructive sleep apnea (OSA) is an important risk factor for the
development of cardiovascular diseases including myocardial infarction (MI). The
aim of this study was to investigate the effects of OSA on prognosis after MI, and
to determine which specific measures of OSA severity best predicted outcomes.
METHODS AND RESULTS: We performed a prospective study, in which 112 patients
without a prior diagnosis of sleep apnea underwent comprehensive polysomnography
within a median of 7 days after MI. Patients were followed up at 6-monthly
intervals (±2 weeks) for a total of 48 months. Patients classified with central
apnea (n=6) or those using continuous positive airway pressure (n=8) after
polysomnography were excluded from analyses. The primary end point was major
adverse cardiac events, including death from any cause, recurrent MI, unstable
angina, heart failure, stroke, and significant arrhythmic events. Forty of 98
patients (41%) had OSA (apnea-hypopnea index ≥15 events/h). OSA patients had higher
major adverse cardiac event rates when compared to those without OSA (47.5% versus
24.1%; χ(2)=5.41, P=0.020). In a multivariate model that adjusted for clinically
relevant variables including age, left ventricular ejection fraction, diabetes
mellitus, oxygen desaturation index, and arousal index, significant hypoxemia, as
defined by nocturnal nadir oxygen saturation ≤85%, was an independent risk factor
for major adverse cardiac events (hazard ratio=6.05, P=0.004) in follow-up
15 months after baseline. CONCLUSIONS: Nocturnal hypoxemia in OSA is an important
predictor of poor prognosis for patients after MI. These findings suggest that
routine use of low-cost nocturnal oximetry may be an economical and practical
approach to stratify risk in post-MI patients.
AD - Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN Pulmonary
Department of Beijing An Zhen Hospital, Capital Medical University, Beijing, China.
Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN.
Department of Otolaryngology-Head and Neck Surgery, Beijing An Zhen Hospital,
Capital Medical University, Beijing, China.
Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN
somers.virend@mayo.edu.
AN - 27464791
AU - Xie, J.
AU - Sert Kuniyoshi, F. H.
AU - Covassin, N.
AU - Singh, P.
AU - Gami, A. S.
AU - Wang, S.
AU - Chahal, C. A.
AU - Wei, Y.
AU - Somers, V. K.
C2 - PMC5015271
DA - Jul 27
DO - 10.1161/jaha.115.003162
DP - NLM
ET - 2016/07/29
IS - 8
KW - Aged
Aged, 80 and over
Angina Pectoris/mortality
Continuous Positive Airway Pressure/mortality
Female
Humans
Hypoxia/mortality
Male
Middle Aged
Myocardial Infarction/*mortality
Polysomnography
Prospective Studies
Recurrence
Risk Factors
Sleep Apnea, Obstructive/*complications/mortality
Stroke/mortality
*hypoxemia
*major adverse cardiac event
*myocardial infarction
*obstructive sleep apnea
LA - eng
N1 - 2047-9980
Xie, Jiang
Sert Kuniyoshi, Fatima H
Covassin, Naima
Singh, Prachi
Gami, Apoor S
Wang, Shihan
Chahal, C Anwar A
Wei, Yongxiang
Somers, Virend K
Journal Article
J Am Heart Assoc. 2016 Jul 27;5(8):e003162. doi: 10.1161/JAHA.115.003162.
PY - 2016
SN - 2047-9980
ST - Nocturnal Hypoxemia Due to Obstructive Sleep Apnea Is an Independent
Predictor of Poor Prognosis After Myocardial Infarction
TI - Nocturnal Hypoxemia Due to Obstructive Sleep Apnea Is an Independent
Predictor of Poor Prognosis After Myocardial Infarction
VL - 5
ID - 2789
ER -
TY - JOUR
AB - OBJECTIVE: To investigate the effects and safety of recombinant human brain
natriuretic peptide (rhBNP) in the treatment of elderly acute myocardial infarction
induced cardiac failure. METHODS: One hundred and forty-six patients who were
diagnosed as elderly acute myocardial infarction induced cardiac failure in the
hospital from July 2014 to July 2015 were selected. They were divided into a test
group and a control group, 73 each. Patients in both groups were given conventional
treatment such as stabilization of atherosclerotic plaques, anti-platelet and
remodeling and reversion of myocardium. The curative effects and the incidence of
adverse reactions of the two groups were observed. RESULTS: The overall efficacy of
the test group and the control group was 87.7% and 65.8% respectively, and the
difference had statistical significance (P<0.05). The heart rate, urine volume, n-
terminal pro-brain natriuretic peptide level and left ventricular ejection fraction
(LVEF) of both groups significantly improved after treatment, and the improvement
of the test group was superior to that of the control group (P<0.05). The serum
creatinine of the test group remarkably reduced after treatment (P<0.05). The
incidence of hypotension and arrhythmia of the test group was lower than that of
the control group during hospitalization period (P<0.05). CONCLUSION: rhBNP can
effectively relieve the clinical symptoms, cardiac function indexes and hemodynamic
indexes of patients with elderly acute myocardial infarction induced cardiac
failure, with a high safety. It can be extensively applied in the treatment of
acute myocardial infarction in combination with cardiac failure.
AD - Hong Xu, Department of Cardiology, Tai'an City Central Hospital, Shandong,
271000, China.
Bosong Wang, Department of Cardiology, Tai'an City Central Hospital, Shandong,
271000, China.
Qingmei Meng, Department of Pediatric, Tai'an City Central Hospital, Shandong,
271000, China.
Jinlong Li, Department of Cardiology, Tai'an City Central Hospital, Shandong,
271000, China.
Weidong Sun, Department of Cardiology, Tai'an City Central Hospital, Shandong,
271000, China.
Li Xin, Department of Cardiology, Tai'an City Central Hospital, Shandong, 271000,
China.
Liping Chen, Department of Pediatric, Tai'an City Central Hospital, Shandong,
271000, China.
AN - 28811767
AU - Xu, H.
AU - Wang, B.
AU - Meng, Q.
AU - Li, J.
AU - Sun, W.
AU - Xin, L.
AU - Chen, L.
C2 - PMC5510099
DA - May-Jun
DO - 10.12669/pjms.333.12483
DP - NLM
ET - 2017/08/16
IS - 3
J2 - Pakistan journal of medical sciences
KW - Acute myocardial infarction
Cardiac failure
Recombinant human brain natriuretic peptide
involved.
LA - eng
N1 - 1681-715x
Xu, Hong
Wang, Bosong
Meng, Qingmei
Li, Jinlong
Sun, Weidong
Xin, Li
Chen, Liping
Journal Article
Pak J Med Sci. 2017 May-Jun;33(3):540-544. doi: 10.12669/pjms.333.12483.
PY - 2017
SN - 1682-024X (Print)
1681-715x
SP - 540-544
ST - Effectiveness and safety of recombinant human brain natriuretic peptide in
the treatment of acute myocardial infarction in elderly in combination with cardiac
failure
T2 - Pak J Med Sci
TI - Effectiveness and safety of recombinant human brain natriuretic peptide in
the treatment of acute myocardial infarction in elderly in combination with cardiac
failure
VL - 33
ID - 3112
ER -
TY - JOUR
AB - Noncompaction of the ventricular myocardium (NVM) is a rare congenital
cardiomyopathy that is characterized by multiple prominent trabeculations and deep
intertrabecular recesses, and occurs due to arrest of normal embryogenesis of the
endocardium and myocardium. It is also referred to as isolated left ventricular
noncompaction (LVNC), because lesions are mainly in the left ventricle. The main
clinical manifestations are heart failure, arrhythmia, systemic embolism, and
sudden death. Systemic embolism is related to the occurrence of atrial arrhythmias
or thrombus formation in the left ventricle. Most resulting thromboembolisms are
cerebral or in the arteries of the lower limbs, and renal artery embolisms are
rare. There are reports of a few previous cases of renal infarction with diagnoses
of NVM on echocardiography, but a thrombus from the left ventricle has never been
identified as the cause of a renal artery embolism. This paper reports a 53-year-
old male who was admitted to our hospital for LVNC and renal infarction. He had a
history of atrial fibrillation 3 years previously. We diagnosed LVNC with a
thrombus in the left ventricle using echocardiography. The patient was discharged
after renal replacement therapy and treatment with an anticoagulant. During the 2
years of follow-up, his condition remained stable.
AD - Department of Geriatrics, The First Affiliated Hospital, School of Medicine,
Zhejiang University, Hangzhou, China.
AN - 29272223
AU - Xu, L.
AU - Yang, J.
AU - Yang, Y.
DA - Dec 7
DO - 10.1532/hsf.1608
DP - NLM
ET - 2017/12/23
IS - 6
J2 - The heart surgery forum
Echocardiography
Embolism/*complications/diagnosis/therapy
Follow-Up Studies
Heart Defects, Congenital/*complications/diagnosis
Heart Diseases/*complications/diagnosis/therapy
*Heart Ventricles
Humans
Infarction/diagnosis/*etiology/therapy
Kidney/*blood supply
Male
Middle Aged
*Renal Artery
Renal Replacement Therapy
Thrombosis
LA - eng
N1 - 1522-6662
Xu, Liqian
Yang, Ji
Yang, Yunmei
Case Reports
Journal Article
United States
Heart Surg Forum. 2017 Dec 7;20(6):E252-E255. doi: 10.1532/hsf.1608.
PY - 2017
SN - 1098-3511
SP - E252-e255
ST - Acute Kidney Infarction Due to Left Ventricular Thrombus Embolization In
Patient with Isolated Left Ventricular Noncompaction: A Case Report
T2 - Heart Surg Forum
TI - Acute Kidney Infarction Due to Left Ventricular Thrombus Embolization In
Patient with Isolated Left Ventricular Noncompaction: A Case Report
VL - 20
ID - 3066
ER -
TY - JOUR
AB - Atrial fibrillation (AF) is the most common cardiac arrhythmia with a
prevalence of up to 10% in patients who are 80 years and older. There has been some
significant progress in the understanding and management of AF in recent years.
Large-scale clinical trials have provided solid evidence in supporting the role of
anti-thrombotic therapies in the prevention of stroke in moderate to high risk
patients. Appropriate control of the ventricular rate or the maintenance of sinus
rhythm offers long-term benefits in specific groups of patients. Catheter ablation
or "Maze" surgery has proven to be curative to some patients. However, the
implementation of the evidence-based therapeutic strategies in the day-to-day care
of the AF patients have been found to vary greatly from one institution to another,
some of which are hindering the achievement of optimal long-term outcomes. In this
brief review, some of the key strategies in the evidence-based management of AF are
discussed, with particular emphasis on anti-thrombotic therapy, rhythm or rate
control, as well as catheter ablation.
AD - Department of Cardiology, Liaocheng People's Hospital, Taishan Medical
College, Shandong Province, PR China.
AN - 20639187
AU - Xue, Y. Z.
AU - Wang, L. X.
DO - 10.2478/v10039-010-0024-5
DP - NLM
ET - 2010/07/20
IS - 2
J2 - Advances in medical sciences
KW - Atrial Fibrillation/*drug therapy/surgery/*therapy
Catheter Ablation
*Evidence-Based Medicine
Humans
Thrombosis/drug therapy
LA - eng
N1 - 1898-4002
Xue, Y Z
Wang, L X
Journal Article
Review
Netherlands
Adv Med Sci. 2010;55(2):130-6. doi: 10.2478/v10039-010-0024-5.
PY - 2010
SN - 1896-1126
SP - 130-6
ST - Contemporary management of atrial fibrillation: a brief review
T2 - Adv Med Sci
TI - Contemporary management of atrial fibrillation: a brief review
VL - 55
ID - 2530
ER -
TY - JOUR
AB - BACKGROUND: The incidence of atrial fibrillation (AF) among patients
undergoing left ventricular assist device (LVAD) implantation is high. However, the
impact of AF on clinical outcomes has not been clarified. We reviewed our 9-year
experience of continuous flow (CF) LVADs to determine the impact of preoperative AF
on stroke, device thrombosis, and survival. METHODS: Between March 2006 and May
2015, 231 patients underwent implantation of 240 CF LVADs, 127 (52.9%) as bridge to
transplantation and 113 (47.1%) as destination therapy. Effect of AF on
postoperative outcomes was assessed by using Kaplan-Meier survival and Cox
proportional hazard regression. RESULTS: There were 78 patients (32.5%) with
preoperative AF with a mean age of 55.7 ± 11.4 years. A similar incidence of stroke
was found in patients with and without AF, 12.8% versus 16.0%, respectively (p =
0.803). Survival was similar, with 1-, 6-, 12-, and 24-month survivals of 96.2%,
91.7%, 84.5%, and 69.2%, respectively, for AF patients, versus 93.1%, 85.0%, 79.4%,
and 74.1%, respectively, for non-AF patients (p = 0.424). Preoperative AF was not a
significant independent predictor of survival with the use of Cox proportional
hazard regression (hazard ratio 1.08, 95% confidence interval: 0.66 to 1.76).
CONCLUSIONS: Preoperative AF was associated with a similar incidence of
postoperative stroke, device thrombosis, and survival. On the basis of these data,
it seems unnecessary to perform a left atrial appendage ligation or to alter
postoperative anticoagulation in patients with AF undergoing LVAD implantation.
AD - Division of Cardiothoracic Surgery, Henry Ford Hospital, Heart and Vascular
Institute, Detroit, Michigan.
Division of Cardiothoracic Surgery, Henry Ford Hospital, Heart and Vascular
Institute, Detroit, Michigan. Electronic address: jamorganmd@hotmail.com.
AN - 27469338
AU - Xuereb, L.
AU - Go, P. H.
AU - Kaur, B.
AU - Akrawe, S.
AU - Nemeh, H. W.
AU - Borgi, J.
AU - Williams, C. T.
AU - Paone, G.
AU - Morgan, J. A.
DA - Nov
DO - 10.1016/j.athoracsur.2016.04.025
DP - NLM
ET - 2016/10/25
IS - 5
KW - Adult
Aged
Atrial Appendage/surgery
Equipment Failure
Female
Heart Failure/complications/surgery
Humans
Incidence
Intensive Care Units/statistics & numerical data
Male
Middle Aged
Thrombophilia/drug therapy/etiology
Treatment Outcome
Unnecessary Procedures
LA - eng
N1 - 1552-6259
Xuereb, Linnea
Go, Pauline H
Kaur, Babbaljeet
Akrawe, Silvy
Nemeh, Hassan W
Borgi, Jamil
Williams, Celeste T
Paone, Gaetano
Morgan, Jeffrey A
Journal Article
Netherlands
Ann Thorac Surg. 2016 Nov;102(5):1543-1549. doi: 10.1016/j.athoracsur.2016.04.025.
Epub 2016 Jul 25.
PY - 2016
SN - 0003-4975
SP - 1543-1549
ST - Impact of Preoperative Atrial Fibrillation on Postoperative Thromboembolic
Events After Left Ventricular Assist Device Implantation
TI - Impact of Preoperative Atrial Fibrillation on Postoperative Thromboembolic
Events After Left Ventricular Assist Device Implantation
VL - 102
ID - 2548
ER -
TY - JOUR
AB - BACKGROUND: Since the preoperative left ventricular end-systolic volume index
(LVESVI) of greater than 100 mL/m2 was demonstrated to be an independent predictor
of long-term mortality following isolated coronary artery bypass grafting (CABG),
LV reconstruction (LVR) has been concomitantly performed in patients with a dilated
LV due to ischemic cardiomyopathy. METHODS: We retrospectively assessed the ability
of preoperative and intraoperative variables to affect the actuarial survival in 48
patients with a preoperative LV ejection fraction (EF) of less than 0.30 and a
preoperative LVESVI of greater than 100 mL/m2. Mean preoperative LVEF was 0.22 +/-
0.07, and preoperative LVESVI was 121 +/- 28 mL/m2. Coronary artery bypass grafting
was performed in all patients. Mean number of grafted vessels was 2.8. The LVR was
concomitantly performed in 20 patients and mitral valve plasty in 11. Preoperative
and intraoperative variables were exposed to univariate and multivariate analyses.
RESULTS: There were 3 hospital deaths and 17 late deaths during the follow-up
period. Causes of deaths were pump failure (9), myocardial infarction (2),
ventricular arrhythmia (4), cerebral infarction (2), and cancer (2). Cox's
proportional hazards model identified LVR and renal failure as independent factors,
which affected the actuarial survival with odds ratios of 0.28 and 3.64 (p < 0.05).
The 5-year actuarial survival (Kaplan-Meier) was significantly greater following
LVR (90% +/- 11%) compared to isolated CABG (53% +/- 17%). CONCLUSIONS: Left
ventricular reconstruction contributed to improve the actuarial survival in
patients with dilated ischemic cardiomyopathy, which could not be achieved by
isolated CABG. The LVR can be an alternative to heart transplantation for the
treatment of ischemic cardiomyopathy.
AD - Department of Cardiovascular Surgery, Omiya Medical Center, Jichi Medical
School, Saitama, Japan. yamaatsu@omiya.jichi.ac.jp
AN - 15680814
AU - Yamaguchi, A.
AU - Adachi, H.
AU - Kawahito, K.
AU - Murata, S.
AU - Ino, T.
DA - Feb
DO - 10.1016/j.athoracsur.2004.07.045
DP - NLM
ET - 2005/02/01
IS - 2
Aged
Cardiomyopathy, Dilated/complications/mortality/*surgery
Coronary Artery Bypass
Female
Heart Ventricles/*surgery
Humans
Male
Middle Aged
Myocardial Ischemia/complications/mortality/*surgery
Risk Factors
Survival Rate
Ventricular Dysfunction, Left/complications/mortality/surgery
LA - eng
N1 - 1552-6259
Yamaguchi, Atsushi
Adachi, Hideo
Kawahito, Koji
Murata, Seiichiro
Ino, Takashi
Clinical Trial
Journal Article
Netherlands
Ann Thorac Surg. 2005 Feb;79(2):456-61. doi: 10.1016/j.athoracsur.2004.07.045.
PY - 2005
SN - 0003-4975
SP - 456-61
ST - Left ventricular reconstruction benefits patients with dilated ischemic
cardiomyopathy
TI - Left ventricular reconstruction benefits patients with dilated ischemic
cardiomyopathy
VL - 79
ID - 3094
ER -
TY - JOUR
AB - A 35-year-old man was hospitalized after a sudden onset of transient syncopal
attack without accompanying complaints of headache or nausea. He was slightly
disorientated but neurologically normal. He had a blood pressure of 150/90mmHg and
a pulse rate of 40/min. An ECG showed marked sinus brady-cardia with ventricular
escaped rhythm followed by advanced atrioventricular (AV) block. Some components of
conducted ventricular beats showed aberration. There was no significant ST or T
wave abnormality in normally captured QRS components except for prominent T in
leads II, III and aVF. At first, we thought that he might require temporary pacing
because of Adams-Stokes attack. However, after administration of atropine sulfate,
the ECG returned to normal sinus rhythm with heart rate of 88/min. Then he began to
complain of headache followed by a convulsive seizure. A CT scan and angiogram
revealed a ruptured aneurysm at the top of the basilar artery, which was
successfully clipped. A wide spectrum of ECG changes can be demonstrated in
practically all patients with subarachnoid hemorrhage (SAH). Prolonged QT interval,
ST-T changes, U wave, sinus tachycardia, or ventricular premature complex are the
common abnormalities probably caused by increased circulating catecholamine. As
bradyarrhythmia in patients with SAH is an uncommon finding, its mechanism has not
yet been defined. Transient sinus bradycardia with advanced AV block in this
patient might have been caused not by elevated intracranial pressure (Cushing
phenomenon) but by drastic discharge of the parasympathetic nerve. This case serves
to illustrate the vigilance required in determining whether abnormalities of
cardiac rhythm are instrumental in causing neurological symptoms and signs or a
disorder of cerebral function.
AD - Department of Cardiology, International Goodwill Hospital.
AN - 1518979
AU - Yamanaka, O.
AU - Fujiwara, Y.
AU - Nakamura, T.
AU - Miyakawa, K.
AU - Kamishima, G.
AU - Endoh, M.
AU - Ichikawa, F.
DA - Jul
DP - NLM
ET - 1992/07/01
IS - 7
J2 - Kokyu to junkan. Respiration & circulation
KW - Adult
Electrocardiography
Heart Block/diagnosis/*etiology
Humans
Male
Sick Sinus Syndrome/diagnosis/*etiology
Subarachnoid Hemorrhage/*complications/diagnosis
LA - jpn
N1 - Yamanaka, O
Fujiwara, Y
Nakamura, T
Miyakawa, K
Kamishima, G
Endoh, M
Ichikawa, F
Case Reports
English Abstract
Journal Article
Japan
Kokyu To Junkan. 1992 Jul;40(7):715-9.
PY - 1992
SN - 0452-3458 (Print)
0452-3458
SP - 715-9
ST - [A case of subarachnoid hemorrhage with sick sinus and advanced AV block]
T2 - Kokyu To Junkan
TI - [A case of subarachnoid hemorrhage with sick sinus and advanced AV block]
VL - 40
ID - 2820
ER -
TY - JOUR
AB - BACKGROUND: Apart from stroke, atrial fibrillation (AF) is associated with
higher mortality and heart failure (HF), in which risk stratification scheme is
lacking. Therefore this investigation examined the prognostic value of
echocardiographic predictors against CHA2DS2-VASc score in permanent non- -valvular
AF (NVAF). METHODS: In 252 asymptomatic or mildly symptomatic consecutive patients
with NVAF, comprehensive echocardiography was performed. Left atrial deformation
parameters were also obtained by two-dimen-sional speckle tracking
echocardiography. End-points pertaining to HF deterioration, ischemic stroke and
cardiac death were recorded. RESULTS: There were 74 cardiovascular events,
including 44 deterioration of HF, 22 ischemic strokes and 8 cardiovascular deaths
during an average follow-up period of 20.8 ± 13.5 months (interquartile range, 8-31
months). For prediction of overall prognosis and HF, left ventricular mass index,
peak early filling velocity (E), and E to tissue Doppler mitral annular early
diastolic velocity ratio (E/e') outper-formed CHA2DS2-VASc score in multivariate
analysis, area under curve, and stepwise nested regression models. Left ventricular
hypertrophy and E/e' > 8 showed worse overall and heart-failure free survival in
Kaplan-Meier curves. For prediction of ischemic stroke, the addition of E or E/e'
to CHA2DS2-VASc score provides extra prognostic value. CONCLUSIONS:
Echocardiographic parameters offer incremental value over CHA2DS2-VASc score for
prediction of future cardiac events in NVAF. (Cardiol J 2018; 25, 1: 60-71).
AD - National Cheng Kung University Hospital. litannyang@yahoo.com.tw.
AN - 28714523
AU - Yang, L. T.
AU - Tsai, W. C.
AU - Su, H. M.
DO - 10.5603/CJ.a2017.0086
DP - NLM
ET - 2017/07/18
IS - 1
KW - Aged
Atrial Fibrillation/*complications/diagnosis/physiopathology
Female
Follow-Up Studies
Heart Failure/*diagnosis/epidemiology/etiology
Humans
Incidence
Male
Prognosis
Risk Factors
Stroke/*diagnosis/epidemiology/etiology
Taiwan/epidemiology
*echocardiography
*heart failure
*prognosis
*stroke
LA - eng
N1 - 1897-5593
Yang, Li-Tan
Tsai, Wei-Chuan
Su, Ho-Ming
Journal Article
Poland
Cardiol J. 2018;25(1):60-71. doi: 10.5603/CJ.a2017.0086. Epub 2017 Jul 17.
PY - 2018
SN - 1898-018x
SP - 60-71
ST - Echocardiographic parameters versus CHA2DS2-VASc score in prediction of
overall cardiac events, heart failure, and stroke in non-valvular atrial
fibrillation
T2 - Cardiol J
TI - Echocardiographic parameters versus CHA2DS2-VASc score in prediction of
overall cardiac events, heart failure, and stroke in non-valvular atrial
fibrillation
VL - 25
ID - 2316
ER -
TY - JOUR
AB - BACKGROUND: Many studies have suggested that longer duration of cardiac
monitoring is suitable for the detection of occult paroxysmal atrial fibrillation
(AF) after stroke; however, most studies involved patients aged≥65years - a
population with a high stroke rate. AIMS: To assess the incidence of paroxysmal AF
in unselected young patients presenting with stroke. METHODS: We included
consecutive patients aged<60years with a stroke diagnosis on magnetic resonance
imaging. Aetiological screening included clinical history and examination, and
biological and cardiac tests. Patients were included if they had no history of AF
and if a 24-hour electrocardiogram recording detected no AF or atrial flutter.
Patients wore the SpiderFlash(®) monitor for 21days after discharge from hospital.
The primary outcome was detection of paroxysmal AF episodes lasting>30seconds
during monitoring. The secondary outcome was detection of paroxysmal AF episodes
lasting<30seconds and any arrhythmia during monitoring. RESULTS: Among the 56
patients included (mean age 48±9years), 39 had cryptogenic stroke (CS) and 17 had
stroke of known cause (SKC). Cardiac monitoring was achieved in 54 patients (37 CS,
17 SKC); one CS patient had a paroxysmal AF episode lasting>30seconds and one CS
patient had a paroxysmal AF episode lasting<30seconds (versus no patients in the
SKC group). Two CS patients and one SKC patient presented numerous premature atrial
complexes. Non-sustained ventricular tachycardia was detected in one CS patient.
CONCLUSION: This prospective observational study showed a low rate of paroxysmal AF
among young patients presenting with stroke, on the basis of 21-day cardiac
monitoring. This result highlights the need to identify patients who would benefit
from such long monitoring.
AD - Department of Cardiology, Campus University Teaching Hospital, Lomé, Togo.
Department of Cardiology, Annecy Hospital, Annecy, 74370 Metz-Tessy, France.
Department of Neurology, Annecy Hospital, Annecy, 74370 Metz-Tessy, France.
Department of Cardiology, Annecy Hospital, Annecy, 74370 Metz-Tessy, France.
Electronic address: loic.belle@wanadoo.fr.
AN - 25669959
AU - Yayehd, K.
AU - Irles, D.
AU - Akret, C.
AU - Vadot, W.
AU - Rodier, G.
AU - Berremili, T.
AU - Perenet, S.
AU - Chevallier-Grenot, M.
AU - Belle, L.
AU - Dompnier, A.
DA - Mar
DO - 10.1016/j.acvd.2014.11.003
DP - NLM
ET - 2015/02/12
IS - 3
KW - Adult
Atrial Fibrillation/*diagnosis/epidemiology/etiology
Brain Ischemia/complications
*Electrocardiography, Ambulatory/instrumentation
Female
Humans
Incidence
Male
Middle Aged
Prospective Studies
Time Factors
Accident vasculaire cérébral ischémique
Enregistrement électrocardiographique externe de longue durée
Fibrillation auriculaire paroxystique
Ischaemic stroke
Long external cardiac monitoring
Paroxysmal atrial fibrillation
Patients jeunes
Young patients
LA - eng
N1 - 1875-2128
Yayehd, Komlavi
Irles, Didier
Akret, Chrystelle
Vadot, Wilfried
Rodier, Gilles
Berremili, Toufek
Perenet, Sophie
Chevallier-Grenot, Marie
Belle, Loïc
Dompnier, Antoine
Clinical Study
Journal Article
Netherlands
Arch Cardiovasc Dis. 2015 Mar;108(3):189-96. doi: 10.1016/j.acvd.2014.11.003. Epub
2015 Feb 7.
PY - 2015
SN - 1875-2128
SP - 189-96
ST - Detection of paroxysmal atrial fibrillation by prolonged electrocardiographic
recording after ischaemic stroke in patients aged<60years: a study with 21-day
recording using the SpiderFlash(®) monitor
TI - Detection of paroxysmal atrial fibrillation by prolonged electrocardiographic
recording after ischaemic stroke in patients aged<60years: a study with 21-day
recording using the SpiderFlash(®) monitor
VL - 108
ID - 2466
ER -
TY - JOUR
AB - Objective: To compare the outcome of surgical high-risk elderly patients with
severe aortic stenosis(SAS) treated by different therapy procedures, including
transcatheter aortic valve implantation(TAVI), surgical aortic valve
replacement(SAVR), and drug therapy. Methods: We retrospectively analyzed the
clinical data of 242 surgical high-risk elderly (age ≥65 years old) SAS patients
hospitalized in Fuwai Hospital between September 2012 and June 2015. According to
the treatment method, patients were divided into TAVI group (81 cases), SAVR group
(59 cases) and drug therapy group (102 cases). The primary end point was all-cause
mortality at 1 year post procedure, and secondary end point included cardiac
function class(NYHA), vascular complication, valvular function, non-fatal
myocardial infarction, new atrial fibrillation, stroke, bleeding, pacemaker
implantation, acute renal failure, and readmission. We used the Kaplan-Meier method
to estimate survival function based on follow up data and survival was compared
between groups with the use of the log-rank test. Results: (1) In the baseline
data, there were statistically significant difference among 3 groups for the age,
left ventricular ejection fraction, cardiac function class Ⅲ and Ⅳ, rates of
combined diabetes, chronic renal failure, mild and moderate mitral regurgitation
(P<0.01 or 0.05). The risk score of the Society of Thoracic Surgeons(STS) was
7.28±4.98 in the TAVI group, and 5.67±3.49 in the SAVR group(P=0.036). (2) The
perioperative rates of pacemaker implantation(11.3%(9/81) vs. 0, P=0.025) and mild
paravalvular regurgitation(29.6%(24/81) vs.1.7%(1/59), P<0.001) were significantly
higher in TAVI group than in SAVR group.(3)The rate of rehospitalization was
significantly lower in TAVI group than in SAVR group(3.0%(2/67) vs. 22.7%(10/44)
P=0.005) and the rate of pacemaker implantation was significantly higher in TAVI
group than in SAVR group(17.5 (12/67) vs. 0, P=0.008) after 1 year. The rates of
death from any cause in the TAVI (5.8%(4/67)) and SAVR group (11.4%(5/44)) were
significantly lower than that in the drug therapy group (54.9%(50/91), both P<0.05)
after 1 year and was similar between TAVI group and SAVR group(P=0.622). (4) The
rates of cardiac function classⅠandⅡ increased and Ⅲ and Ⅳ decreased in TAVI
and SAVR group after 1 year when compared with base line(P<0.001). The rates of
cardiac function class Ⅱ, and Ⅲ increased , class Ⅰ and Ⅳ decreased in drug
therapy group after 1 year compared with base line (P=0.020). (5)The survival rates
after 1 year were significantly higher in the TAVI group and SAVR group than in the
drug therapy group(log-rank test, P<0.001), and the difference was similar between
TAVI group and SAVR group (log-rank test, P=0.062). Conclusion: In surgical high-
risk elderly patients with SAS, the prognosis of drug therapy was poor, and TAVI
and SAVR were associated with similarly improved rates of survival after 1 year,
although there were significant differences in periprocedural complications between
TAVI and SAVR groups.
AD - Department of Coronary Heart Disease Center, Fuwai Hospital, National Center
for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union
Medical College, Beijing 100037, China.
AN - 28100340
AU - Ye, Y. Q.
AU - Wang, Y. T.
AU - Li, Z.
AU - Wang, M. Y.
AU - Xu, H. Y.
AU - Zhang, W. J.
AU - Liu, Q. R.
AU - Niu, G. N.
AU - Wu, Y. J.
DA - Jan 25
DO - 10.3760/cma.j.issn.0253-3758.2017.01.004
DP - NLM
ET - 2017/01/20
IS - 1
KW - Age Factors
Aged
Aged, 80 and over
Aortic Valve
Aortic Valve Stenosis/*therapy
Atrial Fibrillation
Female
Humans
Male
Mitral Valve Insufficiency
Myocardial Infarction
Prognosis
Risk Factors
Stroke
Time Factors
*Transcatheter Aortic Valve Replacement
Treatment Outcome
Aortic valve stenosis
Cardiac surgical procedures
Transcatheter aortic valve implantation
LA - chi
N1 - Ye, Y Q
Wang, Y T
Li, Z
Wang, M Y
Xu, H Y
Zhang, W J
Liu, Q R
Niu, G N
Wu, Y J
Journal Article
China
Zhonghua Xin Xue Guan Bing Za Zhi. 2017 Jan 25;45(1):13-18. doi:
10.3760/cma.j.issn.0253-3758.2017.01.004.
PY - 2017
SN - 0253-3758 (Print)
0253-3758
SP - 13-18
ST - [Outcome comparison of different therapy procedures in surgical high-risk
elderly patients with severe aortic stenosis]
TI - [Outcome comparison of different therapy procedures in surgical high-risk
elderly patients with severe aortic stenosis]
VL - 45
ID - 2787
ER -
TY - JOUR
AB - Refractory ventricular arrhythmia is a serious problem in acute myocardial
infarction (AMI), with an extremely high mortality rate and limited effective
treatment. Extracorporeal membrane oxygenation (ECMO) is useful to rescue patients
with cardiopulmonary collapse. However, little is known about whether ECMO is a
potential rescue technique for patients with refractory ventricular arrhythmia in
AMI.We retrospectively analyzed prospectively collected data on patients with AMI
and refractory ventricular arrhythmia who underwent ECMO as rescue therapy and the
bridge to revascularization from February 2001 to January 2013. Primary endpoint
was mortality on index admission, and secondary endpoint was mortality on index
admission or advanced brain damage at discharge.A total of 69 (62 men) patients
were enrolled in this study. During the index admission, 39 patients (56.5%) met
primary endpoint, and 45 patients (65.2%) met secondary endpoint, respectively. In
multivariate Cox regression analysis, both the presence of profound anoxic
encephalopathy and acute renal failure requiring dialysis were significant
predictive factors for both primary and secondary endpoints.ECMO is a feasible
rescue therapy and bridge to revascularization in patients with refractory
ventricular arrhythmia in acute myocardial infarction. The presence of profound
anoxic encephalopathy and acute renal failure requiring dialysis were significant
prognostic factors.
AD - From the Department of Internal Medicine (C-FY, C-KW, Y-HL); and Department
of Surgery(C-HW, Y-SC, P-RT), National Taiwan University Hospital; and National
Taiwan University College of Medicine, Taipei, Taiwan (Y-HL, Y-SC).
AN - 26222862
AU - Yeh, C. F.
AU - Wang, C. H.
AU - Tsai, P. R.
AU - Wu, C. K.
AU - Lin, Y. H.
AU - Chen, Y. S.
C2 - PMC4554118
DA - Jul
DO - 10.1097/md.0000000000001241
DP - NLM
ET - 2015/07/30
IS - 30
J2 - Medicine
KW - Extracorporeal Membrane Oxygenation/*methods
Female
Follow-Up Studies
Humans
Male
Middle Aged
Myocardial Infarction/*complications/mortality
Patient Admission/*trends
Risk Factors
Tachycardia, Ventricular/etiology/mortality/*therapy
Taiwan/epidemiology
Treatment Outcome
LA - eng
N1 - 1536-5964
Yeh, Chih-Fan
Wang, Chih-Hsien
Tsai, Pi-Ru
Wu, Cho-Kai
Lin, Yen-Hung
Chen, Yih-Sharng
Journal Article
Medicine (Baltimore). 2015 Jul;94(30):e1241. doi: 10.1097/MD.0000000000001241.
PY - 2015
SN - 0025-7974 (Print)
0025-7974
SP - e1241
ST - Use of Extracorporeal Membrane Oxygenation to Rescue Patients With Refractory
Ventricular Arrhythmia in Acute Myocardial Infarction
TI - Use of Extracorporeal Membrane Oxygenation to Rescue Patients With Refractory
Ventricular Arrhythmia in Acute Myocardial Infarction
VL - 94
ID - 2804
ER -
TY - JOUR
AB - INTRODUCTION: The aim of this study was to investigate the role of Doppler-
derived left ventricular (LV) -dP/dt in predicting atrial fibrillation (AF) or
ischemic stroke in patients with moderate to severe degenerative mitral
regurgitation (MR). METHODS: Doppler-derived LV -dP/dt was determined from the
continuous-wave Doppler spectrum of the MR jet (-dP/dt = 32/time between 3 and 1
m/sec) in 80 patients (mean age 59 ± 16 years, 41% men) with moderate to severe
degenerative MR, normal LV ejection fraction (LVEF ≥ 60%), and sinus rhythm at
diagnosis. Events were defined as new AF or ischemic stroke. RESULTS: During a mean
follow-up of 18 ± 13 months, there were 9 events (6 new AF, 3 ischemic strokes).
Univariate analysis showed that older age, decreased LV -dP/dt, increased LV mass
index, and left atrial volume index (LAVI), shortened deceleration time (DT),
reduced A' velocity, and elevated E/E' ratio, prolongation of pulmonary venous (PV)
atrial reversal (AR) flow duration relative to mitral inflow A-wave duration (AR-
Adur) were associated with events. In multivariate Cox regression analysis,
Doppler-derived LV -dP/dt (for each 100 mmHg/sec increase, hazard ratio: 0.165, 95%
confidence interval: 0.036-0.761, P = 0.021) and E/E' (hazard ratio: 0.820, 95%
confidence interval: 0.682-0.987, P = 0.036) were significant independent
predictors of AF or ischemic stroke. CONCLUSIONS: Doppler-derived LV -dP/dt is
independently associated with the occurrence of AF or ischemic stroke in patients
with moderate to severe degenerative MR and provides additional prognostic
information.
AD - Division of Cardiology, Department of Internal Medicine, College of Medicine,
The Catholic University of Korea, Seoul, Korea.
AN - 24007645
AU - Yi, J. E.
AU - Lee, D. H.
AU - Cho, E. J.
AU - Jeon, H. K.
AU - Jung, H. O.
AU - Youn, H. J.
DA - Mar
DO - 10.1111/echo.12350
DP - NLM
ET - 2013/09/07
IS - 3
J2 - Echocardiography (Mount Kisco, N.Y.)
KW - Adult
Aged
Atrial Fibrillation/*diagnostic imaging/etiology/physiopathology
Brain Ischemia/diagnostic imaging/etiology/pathology
Cohort Studies
Female
Humans
Male
Middle Aged
Mitral Valve Insufficiency/complications/*diagnostic imaging
Prognosis
ROC Curve
Risk Assessment
Stroke/*diagnostic imaging/etiology
Ventricular Dysfunction, Left/complications/diagnostic imaging
Doppler-derived LV −dP/dt
atrial fibrillation
degenerative mitral regurgitation
ischemic stroke
LA - eng
N1 - 1540-8175
Yi, Jeong-Eun
Lee, Dong-Hyeon
Cho, Eun Joo
Jeon, Hui-Kyung
Jung, Hae-Ok
Youn, Ho-Joong
Comparative Study
Journal Article
United States
Echocardiography. 2014 Mar;31(3):285-92. doi: 10.1111/echo.12350. Epub 2013 Sep 6.
PY - 2014
SN - 0742-2822
SP - 285-92
ST - Doppler-derived left ventricular negative dP/dt as a predictor of atrial
fibrillation or ischemic stroke in patients with degenerative mitral regurgitation
and normal ejection fraction
T2 - Echocardiography
TI - Doppler-derived left ventricular negative dP/dt as a predictor of atrial
fibrillation or ischemic stroke in patients with degenerative mitral regurgitation
and normal ejection fraction
VL - 31
ID - 2356
ER -
TY - JOUR
AB - BACKGROUND: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare
inherited cardiomyopathy with a high burden of ventricular arrhythmia, which is an
important cause of sudden cardiac death (SCD). Implantable cardioverter-
defibrillator (ICD) is believed to be the most reliable management against SCD.
HYPOTHESIS: Ventricular arrhythmia does not necessarily confer a poor prognosis in
ARVC patients with an ICD. METHODS: A total of 39 ARVC patients (34 male) implanted
with an ICD at our electrophysiology center and followed up continuously were
included in this study. The mean age at diagnosis was 42.1 ± 14.8 years. RESULTS:
Thirty-three patients (84.6%) had suffered ventricular arrhythmia with hemodynamic
compromise before ICD implantation. During a median follow-up of 48.6 months
(interquartile range, 32.3-73.3), 3 patients (7.7%) died, 1 of sudden death, 1 of
heart failure, and 1 of cerebral infarction. Twenty-eight patients (71.8%)
experienced 540 appropriate ICD interventions. The first appropriate ICD
intervention occurred more than 2 years after initial ICD implantation in 5
patients (12.8%). Twelve patients (30.8%) suffered from electrical storm. The
event-free period was significantly shorter in patients who did not have broad
precordial T wave inversion ≥V1-V3 (hazard ratio = 0.39, 95% confidence interval:
0.16-0.96). No significant difference was shown in antiarrhythmic drugs and
radiofrequency catheter ablation before ICD implantation between patients with and
without appropriate ICD therapies (P > 0.05). CONCLUSIONS: Recurrence of sustained
ventricular tachycardia/ventricular fibrillation is frequent in high-risk patients
with ARVC. The prognosis is favorable for ARVC patients treated with an ICD for
prevention of SCD.
AD - State Key Laboratory of Cardiovascular Disease, Cardiac Arrhythmia Center,
Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of
Medical Sciences and Peking Union Medical College, Beijing, People's Republic of
China.
AN - 28139837
AU - Yin, K.
AU - Ding, L.
AU - Li, Y.
AU - Hua, W.
C2 - PMC6490430
DA - Apr
DO - 10.1002/clc.22648
DP - NLM
ET - 2017/02/01
IS - 4
KW - Adult
Arrhythmogenic Right Ventricular Dysplasia/complications/mortality/*therapy
China/epidemiology
Death, Sudden, Cardiac/epidemiology/etiology/*prevention & control
Female
Follow-Up Studies
Humans
Incidence
Male
Prognosis
Time Factors
T wave inversion
arrhythmogenic right ventricular cardiomyopathy/dysplasia
implantable cardioverter-defibrillator
ventricular tachycardia/ventricular fibrillation
LA - eng
N1 - 1932-8737
Yin, Kang
Ding, Ligang
Li, Yuqiu
Hua, Wei
Journal Article
Clin Cardiol. 2017 Apr;40(4):216-221. doi: 10.1002/clc.22648. Epub 2017 Jan 31.
PY - 2017
SN - 0160-9289 (Print)
0160-9289
SP - 216-221
ST - Long-term follow-up of arrhythmogenic right ventricular cardiomyopathy
patients with an implantable cardioverter-defibrillator for prevention of sudden
cardiac death
T2 - Clin Cardiol
TI - Long-term follow-up of arrhythmogenic right ventricular cardiomyopathy
patients with an implantable cardioverter-defibrillator for prevention of sudden
cardiac death
VL - 40
ID - 3063
ER -
TY - JOUR
AB - Hypertrophic cardiomyopathy (HCM) has various morphological and clinical
features. A decade has passed since the previous survey of the epidemiological and
clinical characteristics of Japanese HCM patients. The Aichi Hypertrophic
Cardiomyopathy (AHC) Registry is based on a prospective multicenter observational
study of HCM patients. The clinical characteristics of 42 ambulant HCM patients
followed up for up to 5 years were investigated. The primary endpoint was major
adverse cardiac events (MACE), defined as death, non-fatal stroke, admission due to
congestive heart failure (CHF), or episodes of sustained ventricular
tachycardia/fibrillation. The MACE-free survival during the 5-year follow-up period
was 76% according to Kaplan-Meier analysis. HCM-related death occurred in 3 (7%)
patients and SCD occurred in 2 (5%) patients. Additionally, 3 (7%) patients were
admitted to the hospital due to CHF. Meanwhile, sustained VT was detected in one
(2%) of the patients who received ICD implantation and subsequently terminated with
antitachycardia pacing using an ICD. The patients with HCM exhibiting left
ventricular outflow obstruction (HOCM) had a slightly lower MACE-free survival rate
than those with neither HOCM nor dilated-HCM (dHCM) (71% versus 81%, log-rank P =
0.581). Furthermore, the patients with dHCM demonstrated a significantly lower
MACE-free survival rate than those with neither HOCM nor dHCM (33% versus 81%, log-
rank P = 0.029). In the AHC Registry targeting current Japanese HCM patients, we
demonstrated that many HCM patients continue to suffer from MACE despite the
development of various treatments for HCM.
AD - Department of Cardiology, Fujita Health University Banbuntane-Hotokukai
Hospital.
AN - 26084460
AU - Yoshinaga, M.
AU - Yoshikawa, D.
AU - Ishii, H.
AU - Hirashiki, A.
AU - Okumura, T.
AU - Kubota, A.
AU - Sakai, S.
AU - Harada, K.
AU - Somura, F.
AU - Mizuno, T.
AU - Fujiwara, W.
AU - Yokoi, H.
AU - Hayashi, M.
AU - Ishii, J.
AU - Ozaki, Y.
AU - Murohara, T.
AU - Yoshida, Y.
AU - Amano, T.
AU - Izawa, H.
DO - 10.1536/ihj.14-418
DP - NLM
ET - 2015/06/19
IS - 4
KW - Aged
*Cardiomyopathy, Hypertrophic/complications/diagnosis/epidemiology
*Death
Electric Countershock/methods
Female
Follow-Up Studies
*Heart Failure/diagnosis/epidemiology/etiology/therapy
Humans
Japan/epidemiology
Male
Middle Aged
Prognosis
*Stroke/epidemiology/etiology
Survival Analysis
*Ventricular Fibrillation/epidemiology/etiology/therapy
LA - eng
N1 - 1349-3299
Yoshinaga, Masataka
Yoshikawa, Daiji
Ishii, Hideki
Hirashiki, Akihiro
Okumura, Takahiro
Kubota, Aki
Sakai, Shinichi
Harada, Ken
Somura, Fuji
Mizuno, Tomofumi
Fujiwara, Wakaya
Yokoi, Hiroatsu
Hayashi, Mutsuharu
Ishii, Junichi
Ozaki, Yukio
Murohara, Toyoaki
Yoshida, Yukihiko
Amano, Tetsuya
Izawa, Hideo
Journal Article
Multicenter Study
Observational Study
Japan
Int Heart J. 2015;56(4):415-20. doi: 10.1536/ihj.14-418. Epub 2015 Jun 18.
PY - 2015
SN - 1349-2365
SP - 415-20
ST - Clinical Characteristics and Long-Term Outcomes of Hypertrophic
Cardiomyopathy
T2 - Int Heart J
TI - Clinical Characteristics and Long-Term Outcomes of Hypertrophic
Cardiomyopathy
VL - 56
ID - 2645
ER -
TY - JOUR
AB - Although the clinical relevance of aneurysm of the membranous ventricular
septum (AMVS) in adults is unclear, the frequency of AMVS detection has been
increased because cardiac multidetector computed tomography has been widely adopted
for the evaluation of coronary artery disease. Therefore, we aimed to assess the
clinical significance of AMVS in a longitudinal study. In 30,120 adults with
suspected coronary artery disease who underwent cardiac multidetector computed
tomography in 3 hospitals, 52 patients with AMVS were retrospectively selected. We
evaluated the clinical symptoms and electrocardiographic abnormalities (cross-
sectional study) and the prevalence of embolic stroke (observational study) during
a median 40-month (range 6 to 74 months) observation period. For the assessment of
embolic stroke, we excluded 9 patients with other explainable embolic sources.
Conduction abnormalities were noted in 13 of 52 adults (25%) with AMVS on
electrocardiography and embolic stroke occurred in 6 of 43 patients (14%). The mean
age and the prevalence of hypertension were significantly higher in the embolic
stroke group than in the event-free group (p <0.05). Thrombi were detected in the
11.6% of AMVS, which was significantly related with embolic stroke (p <0.05). The
size and morphology did not change in 15 patients with serial follow-up images. In
conclusion, our study suggests that AMVS in adults should not be ignored because
AMVS may be related to conduction abnormality or embolic stroke, and it does not
spontaneously resolve or diminish in size.
AD - Department of Radiology, Seoul National University Bundang Hospital,
Seongnam-si, Gyeonggido, Korea.
Department of Radiology, Seoul National University Bundang Hospital, Seongnam-si,
Gyeonggido, Korea. Electronic address: drejchun@hanmail.net.
Department of Radiology, Seoul National University Hospital, Seoul, Korea.
Department of Radiology, University of Ulsan College of Medicine, Asan Medical
Center, Seoul, Korea.
Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
Department of Internal Medicine and Cardiovascular Center, Seoul National
University Bundang Hospital, Seongnam-si, Gyeonggido, Korea.
AN - 25491239
AU - You, J. Y.
AU - Chun, E. J.
AU - Choi, S. I.
AU - Joe, E.
AU - Lee, W.
AU - Kang, J. W.
AU - Seo, M. K.
AU - Yoon, Y. E.
AU - Oh, I. Y.
AU - Kim, E.
AU - Lim, T. H.
DA - Feb 1
DO - 10.1016/j.amjcard.2014.11.010
DP - NLM
ET - 2014/12/11
IS - 3
KW - Adult
Age Factors
Aged
Cardiac-Gated Imaging Techniques
Cohort Studies
Coronary Artery Disease/diagnostic imaging
Databases, Factual
Electrocardiography
Female
Heart Aneurysm/complications/*diagnostic imaging
Heart Diseases/complications/diagnostic imaging
Humans
Incidental Findings
Male
Middle Aged
Multidetector Computed Tomography
Stroke/*etiology
Thrombosis/complications/*diagnostic imaging
Ultrasonography
Ventricular Septum/*diagnostic imaging
LA - eng
N1 - 1879-1913
You, Ja Yeon
Chun, Eun Ju
Choi, Sang Il
Joe, Eugene
Lee, Whal
Kang, Joon-Won
Seo, Myung-Ki
Yoon, Yeonyee E
Oh, Il-Young
Kim, Eunhee
Lim, Tae-Hwan
Journal Article
United States
Am J Cardiol. 2015 Feb 1;115(3):354-9. doi: 10.1016/j.amjcard.2014.11.010. Epub
2014 Nov 13.
PY - 2015
SN - 0002-9149
SP - 354-9
ST - Clinical significance of incidentally detected aneurysms of the membranous
ventricular septum in adults by multidetector computed tomography
T2 - Am J Cardiol
TI - Clinical significance of incidentally detected aneurysms of the membranous
ventricular septum in adults by multidetector computed tomography
VL - 115
ID - 2451
ER -
TY - JOUR
AB - The purpose of this article is to educate staff nurses and advanced practice
nurses the importance of identifying, diagnosing, and making appropriate clinical
decisions when treating patients with atrial fibrillation. Atrial fibrillation is a
supraventricular arrhythmia characterized by uncoordinated, chaotic electrical
activity and deterioration of proper atrial mechanical function, with an irregular
ventricular response. Poorly controlled or undiagnosed atrial fibrillation
increases the risk of mortality and may decrease quality of life. Identifying and
staying abreast of cardiovascular care and current updates in treatment is strongly
encouraged as guidelines are revised and updated as new treatments evolve.
AD - Louisiana Heart Center, 901 East Gause Boulevard, Slidell, LA 70458, USA.
Electronic address: Monique.young@laheart.org.
AN - 30736937
AU - Young, M.
DA - Mar
DO - 10.1016/j.cnc.2018.11.005
DP - NLM
ET - 2019/02/10
IS - 1
J2 - Critical care nursing clinics of North America
KW - Antithrombins/therapeutic use
Atrial Fibrillation/*drug therapy/*nursing
*Critical Care Nursing
Dabigatran/therapeutic use
Hemorrhage/prevention & control
Humans
Rivaroxaban/therapeutic use
Apixaban
Atrial fibrillation
Dabigatran
Rivaroxaban
LA - eng
N1 - 1558-3481
Young, Monique
Journal Article
Review
United States
Crit Care Nurs Clin North Am. 2019 Mar;31(1):77-90. doi: 10.1016/j.cnc.2018.11.005.
PY - 2019
SN - 0899-5885
SP - 77-90
ST - Atrial Fibrillation
T2 - Crit Care Nurs Clin North Am
TI - Atrial Fibrillation
VL - 31
ID - 2289
ER -
TY - JOUR
AB - BACKGROUND: It is apparent that despite lack of family history, patients with
the morphological characteristics of left ventricular non-compaction develop
arrhythmias, thrombo-embolism and left ventricular dysfunction. METHODS: Forty two
patients, aged 48.7 +/- 2.3 yrs (mean +/- SEM) underwent cardiovascular magnetic
resonance (CMR) for the quantification of left ventricular volumes and extent of
non-compacted (NC) myocardium. The latter was quantified using planimetry on the
two-chamber long axis LV view (NC area). The patients included those referred
specifically for CMR to investigate suspected cardiomyopathy, and as such is
represents a selected group of patients. RESULTS: At presentation, 50% had
dyspnoea, 19% chest pain, 14% palpitations and 5% stroke. Pulmonary embolism had
occurred in 7% and brachial artery embolism in 2%. The ECG was abnormal in 81% and
atrial fibrillation occurred in 29%. Transthoracic echocardiograms showed features
of NC in only 10%. On CMR, patients who presented with dyspnoea had greater left
ventricular volumes (both p < 0.0001) and a lower left ventricular ejection
fraction (LVEF) (p < 0.0001) than age-matched, healthy controls. In patients
without dyspnoea (n = 21), NC area correlated positively with end-diastolic volume
(r = 0.52, p = 0.0184) and end-systolic volume (r = 0.56, p = 0.0095), and
negatively with EF (r = -0.72, p = 0.0001). CONCLUSION: Left ventricular non-
compaction is associated with dysrrhythmias, thromboembolic events, chest pain and
LV dysfunction. The inverse correlation between NC area and EF suggests that NC
contributes to left ventricular dysfunction.
AD - Department of Cardiology, Good Hope Hospital, Sutton Coldfield, West
Midlands, UK. z@yousef.me.uk
AN - 19664240
AU - Yousef, Z. R.
AU - Foley, P. W.
AU - Khadjooi, K.
AU - Chalil, S.
AU - Sandman, H.
AU - Mohammed, N. U.
AU - Leyva, F.
C2 - PMC2743643
DA - Aug 9
DO - 10.1186/1471-2261-9-37
DP - NLM
ET - 2009/08/12
KW - Angina Pectoris/diagnosis/etiology
Arrhythmias, Cardiac/diagnosis/etiology
Arterial Occlusive Diseases/diagnosis/etiology
Brachial Artery/pathology
Dyspnea/diagnosis/etiology
Echoencephalography
Electrocardiography
Female
Humans
Isolated Noncompaction of the Ventricular
Myocardium/complications/*diagnosis/physiopathology
*Magnetic Resonance Imaging, Cine
Male
Middle Aged
Pulmonary Embolism/diagnosis/etiology
Stroke/diagnosis/etiology
Stroke Volume
Time Factors
Ventricular Dysfunction, Left/*diagnosis/etiology/physiopathology
LA - eng
N1 - 1471-2261
Yousef, Zaheer R
Foley, Paul W X
Khadjooi, Kayvan
Chalil, Shajil
Sandman, Harald
Mohammed, Noor U H
Leyva, Francisco
Journal Article
BMC Cardiovasc Disord. 2009 Aug 9;9:37. doi: 10.1186/1471-2261-9-37.
PY - 2009
SN - 1471-2261
SP - 37
ST - Left ventricular non-compaction: clinical features and cardiovascular
TI - Left ventricular non-compaction: clinical features and cardiovascular
VL - 9
ID - 2443
ER -
TY - JOUR
AB - The aim of the study was to examine the predictive value of N-terminal pro-
brain natriuretic peptide (NT-pro-BNP) versus electrophysiologic study in patients
with implantable cardioverter-defibrillators (ICDs) after myocardial infarction
(MI). We prospectively studied 99 consecutive patients with a history of MI who
underwent ICD implantation for primary or secondary prevention of sudden cardiac
death. An electrophysiologic study was performed in all patients. Venous blood
samples for NT-pro-BNP measurement were obtained at the beginning of the study. The
primary end point was ventricular tachycardia or ventricular fibrillation (VT/VF)
and the secondary end point was a composite of death, hospitalization for heart
failure, or MI. On multivariate Cox regression analysis, NT-pro-BNP level at or
greater than median (497 ng/L) was the only significant predictor for VT/VF
occurrence (p = 0.047). Along with amiodarone use (p = 0.001), NT-pro-BNP levels
higher than median were also associated with a higher risk of composite clinical
events (p = 0.036). Kaplan-Meier analysis showed that patients with NT-pro-BNP
level at or greater than median had a higher risk of experiencing VT/VF and
composite clinical events than patients with NT-pro-BNP levels less than median
(log-rank p <0.05). In conclusion, assay of NT-pro-BNP, which is easy to perform
and widely available, is superior to electrophysiologic study for prediction of
future outcomes in predominantly secondary prophylactic ICD recipients after MI. In
the era of primary prophylactic ICD implantation without preimplantation
electrophysiologic study, higher NT-pro-BNP levels might help to improve risk-
adjusted concomitant antiarrhythmic therapy and device selection.
AD - Department of Cardiovascular Medicine, Hannover Medical School, Hannover,
Germany.
AN - 17697820
AU - Yu, H.
AU - Oswald, H.
AU - Gardiwal, A.
AU - Lissel, C.
AU - Klein, G.
DA - Aug 15
DO - 10.1016/j.amjcard.2007.03.074
DP - NLM
ET - 2007/08/19
IS - 4
KW - Aged
Arrhythmias, Cardiac/blood/complications/*therapy
Death, Sudden, Cardiac/epidemiology/etiology/*prevention & control
Female
Humans
Male
*Myocardial Infarction/blood/complications/physiopathology
Prognosis
Protein Precursors
Risk Factors
Survival Rate
LA - eng
N1 - Yu, Hong
Oswald, Hanno
Gardiwal, Ajmal
Lissel, Christoph
Klein, Gunnar
Journal Article
United States
Am J Cardiol. 2007 Aug 15;100(4):635-9. doi: 10.1016/j.amjcard.2007.03.074. Epub
2007 Jun 26.
PY - 2007
SN - 0002-9149 (Print)
0002-9149
SP - 635-9
ST - Comparison of N-terminal pro-brain natriuretic peptide versus
electrophysiologic study for predicting future outcomes in patients with an
implantable cardioverter defibrillator after myocardial infarction
T2 - Am J Cardiol
TI - Comparison of N-terminal pro-brain natriuretic peptide versus
electrophysiologic study for predicting future outcomes in patients with an
implantable cardioverter defibrillator after myocardial infarction
VL - 100
ID - 2875
ER -
TY - JOUR
AB - INTRODUCTION: Left ventricular assist device (LVAD) support is associated
with many complications, but relatively few studies have examined the full spectrum
of complications beyond infectious and bleeding events. METHODS: We conducted a
retrospective review of patients receiving either a pulsatile-flow Heartmate XVE
(HM1; Thoratec Corp., Pleasanton, CA, USA) or continuous-flow Heartmate II (HM2;
Thoratec Corp.) LVAD at our institution (June 2000 to March 2012). Frequency and
date of onset of nonbleeding, noninfectious complications were examined. RESULTS:
One hundred eighty-two LVADs were implanted, 49 HM1, and 133 HM2. Support duration
was longer for HM2s (median 358 vs. 112 days; p = 0.0003). Overall, the most
frequent complications were respiratory failure, ventricular arrhythmia, atrial
arrhythmia, right heart failure, and renal failure. Respiratory failure,
arrhythmias, severe psychiatric events, and renal failure all occurred with median
date of onset ≤ seven days postprocedure. Right heart failure, hepatic failure,
thromboembolism, and transient ischemic attacks had a median date of onset 8 to 30
days postprocedure. Stroke, hemolysis, and device failure occurred mostly more than
a month postoperatively. Right heart failure, hepatic failure, and device failure
were more frequent in HM1 patients than in HM2 patients. Several events, including
stroke, had much later onset in HM2 patients. CONCLUSION: In this 10-year review of
complications following LVAD implantation, the most common adverse events tended to
occur early after implantation. As pulsatile-flow HM1s showed greater frequency and
earlier onset of some adverse events, our data suggest better overall outcomes with
the continuous-flow HM2s.
AD - Division of Cardiac Surgery, The Johns Hopkins Medical Institutions,
Baltimore, Maryland 21287, USA.
AN - 22978843
AU - Yuan, N.
AU - Arnaoutakis, G. J.
AU - George, T. J.
AU - Allen, J. G.
AU - Ju, D. G.
AU - Schaffer, J. M.
AU - Russell, S. D.
AU - Shah, A. S.
AU - Conte, J. V.
DA - Sep
DO - 10.1111/j.1540-8191.2012.01504.x
DP - NLM
ET - 2012/09/18
IS - 5
J2 - Journal of cardiac surgery
KW - Academic Medical Centers
Adult
Arrhythmias, Cardiac/epidemiology/*etiology
Cohort Studies
Equipment Design
Equipment Failure/statistics & numerical data
Equipment Safety
Female
Follow-Up Studies
Heart Failure/epidemiology/*etiology
Humans
Incidence
Liver Failure/epidemiology/*etiology
Male
Middle Aged
Postoperative Complications/diagnosis/epidemiology
Survival Analysis
United States
LA - eng
N1 - 1540-8191
Yuan, Nance
Arnaoutakis, George J
George, Timothy J
Allen, Jeremiah G
Ju, Derek G
Schaffer, Justin M
Russell, Stuart D
Shah, Ashish S
Conte, John V
Comparative Study
Journal Article
United States
J Card Surg. 2012 Sep;27(5):630-8. doi: 10.1111/j.1540-8191.2012.01504.x.
PY - 2012
SN - 0886-0440
SP - 630-8
ST - The spectrum of complications following left ventricular assist device
placement
T2 - J Card Surg
TI - The spectrum of complications following left ventricular assist device
placement
VL - 27
ID - 2435
ER -
TY - JOUR
AB - BACKGROUND AND AIMS: Increasingly, insertable cardiac monitors (ICM) have
been used to detect Atrial Fibrillation (AF) in patients with cryptogenic stroke or
embolic strokes of undetermined source (ESUS). We aim to examine the
characteristics of these patients who were subsequently found to have AF. METHODS:
We studied 83 consecutive patients who were comprehensively evaluated using
neuroimaging and vessel imaging (computed tomography angiography, magnetic
resonance angiography, or transcranial and extracranial Doppler sonography) to have
met the previously established ESUS criteria. All 83 patients had ICM implanted
between 2015 and 2017. All patients were followed up for at least 1 year, with a
median follow-up period of 1.5 ± .5 years. We compared the baseline clinical,
laboratory, echocardiographic, neuro-imaging profiles, and clinical outcomes in
terms of functional recovery, recurrent stroke, and mortality in patients with and
without detected AF. RESULTS: AF detection rate in this ESUS cohort was 12% over
the study period. Patients with detected AF were associated with bilateral infarcts
pattern at presentation (30% versus 5.5%, P = .035). Infarcts involving multiple
vascular territories was not significantly associated with the detection of AF.
There were no significant differences in the other clinical characteristics and
outcomes between the AF group compared to the group without detected AF.
Echocardiographic parameters including left ventricular ejection fraction and left
atrial diameter were also not shown to be significantly different. CONCLUSION: Our
study found that a neuroimaging profile of bilateral infarcts was associated with
AF detection using insertable cardiac monitor in ESUS patients. Larger prospective
studies are needed to validate our findings.
AD - National University of Singapore, Yong Loo Lin School of Medicine, Singapore,
Singapore.
National University of Singapore, Yong Loo Lin School of Medicine, Singapore,
Singapore; Division of Neurology, Department of Medicine, National University
Health System, Singapore, Singapore.
Division of Neurology, Department of Medicine, National University Health System,
Singapore, Singapore.
Singapore; Department of Cardiology, National University Heart Centre, Singapore,
Singapore.
Singapore; Division of Neurology, Department of Medicine, National University
Health System, Singapore, Singapore. Electronic address: leonardyeoll@gmail.com.
AN - 31307898
AU - Yushan, B.
AU - Tan, B. Y. Q.
AU - Ngiam, N. J.
AU - Chan, B. P. L.
AU - Luen, T. H.
AU - Sharma, V. K.
AU - Sia, C. H.
AU - Dalakoti, M.
AU - Chong, S. S.
AU - Kojodjojo, P.
AU - Yeo, L. L. L.
DA - Sep
DP - NLM
ET - 2019/07/17
IS - 9
KW - Aged
Atrial Fibrillation/*diagnosis/epidemiology/mortality/therapy
Brain Infarction/diagnostic imaging/*epidemiology/mortality/therapy
Female
*Heart Rate
Humans
Incidence
Intracranial Embolism/diagnostic imaging/*epidemiology/mortality/therapy
Male
Middle Aged
Monitoring, Ambulatory/*instrumentation
Neuroimaging/methods
Recovery of Function
Recurrence
Risk Assessment
Risk Factors
Singapore/epidemiology
Telemetry/*instrumentation
Time Factors
Treatment Outcome
Esus
Ischemic stroke
atrial fibrillation
cryptogenic
implantable
loop recorder
LA - eng
N1 - 1532-8511
Yushan, Boi
Tan, Benjamin Y Q
Ngiam, Nicholas Jinghao
Chan, Bernard P L
Luen, Teoh Hock
Sharma, Vijay K
Sia, Ching-Hui
Dalakoti, Mayank
Chong, Seow Swee
Kojodjojo, Pipin
Yeo, Leonard L L
Journal Article
Observational Study
United States
J Stroke Cerebrovasc Dis. 2019 Sep;28(9):2448-2452. doi:
10.1016/j.jstrokecerebrovasdis.2019.06.025. Epub 2019 Jul 13.
PY - 2019
SN - 1052-3057
SP - 2448-2452
ST - Association between Bilateral Infarcts Pattern and Detection of Occult Atrial
Fibrillation in Embolic Stroke of Undetermined Source (ESUS) Patients with
Insertable Cardiac Monitor (ICM)
TI - Association between Bilateral Infarcts Pattern and Detection of Occult Atrial
Fibrillation in Embolic Stroke of Undetermined Source (ESUS) Patients with
Insertable Cardiac Monitor (ICM)
VL - 28
ID - 2303
ER -
TY - JOUR
AB - The high incidence of association between sleep apnea syndrome and cardiac
disturbance was widely descripted during the last decade and has been the target of
intensive investigation. Our retrospective study included 12 patients with sleep
apnea syndrome diagnosed by polysomnography. 7 patients had HTA with left
ventricular hypertrophy (5 cases). The CPAP stabilise blood pressure in 6 of them,
3 patients had ventricular or atrial arrhythmia. CPAP resolved 2 of them. 3 other
patients had coronaropathy. Another one presented stoke. The sleep apnea syndrome
has been descripted in association with heart failure or unstable HTA.
AD - Service de cardiologie, Hôpital des FSI, La Marsa.
AN - 12664505
AU - Zakhama, L.
AU - Benyoussef, S.
AU - Boussabeh, E.
AU - Jaafari, A.
AU - Boukhris, B.
AU - Thameur, M.
AU - Fajraoui, N.
AU - Charfi, R.
DA - Dec
DP - NLM
ET - 2003/04/01
IS - 12
J2 - La Tunisie medicale
KW - Adult
Aged
Arrhythmias, Cardiac/epidemiology/etiology
Cardiovascular Diseases/epidemiology/*etiology
Coronary Disease/epidemiology/etiology
Female
Humans
Hypertension/epidemiology/etiology
Hypertrophy, Left Ventricular/epidemiology/etiology
Incidence
Male
Middle Aged
Obesity/complications
Polysomnography
Sleep Apnea Syndromes/*complications/diagnosis
Tunisia/epidemiology
LA - fre
N1 - Zakhama, Lilia
Benyoussef, Soraya
Boussabeh, Elhem
Jaafari, Aïcha
Boukhris, Besma
Thameur, Moez
Fajraoui, Nadia
Charfi, Ridha
English Abstract
Journal Article
Tunisia
Tunis Med. 2002 Dec;80(12):775-80.
OP - Les complications cardiovasculaires du syndrome d'apnées du sommeil.
PY - 2002
SN - 0041-4131 (Print)
0041-4131
SP - 775-80
ST - [Cardiovascular complications of sleep apnea syndromes]
T2 - Tunis Med
TI - [Cardiovascular complications of sleep apnea syndromes]
VL - 80
ID - 2759
ER -
TY - JOUR
AD - From Department of Medicine, Cardiac Electrophysiology (P.C.Z.), and
Department of Neurology, Stroke Service, Stanford University, CA (N.V.).
paulzei@stanford.edu.
From Department of Medicine, Cardiac Electrophysiology (P.C.Z.), and Department of
Neurology, Stroke Service, Stanford University, CA (N.V.).
AN - 28242639
AU - Zei, P. C.
AU - Vora, N.
DA - Feb 28
DP - NLM
ET - 2017/03/01
IS - 9
J2 - Circulation
KW - Catheter Ablation
Heart Ventricles/*surgery
Humans
Stroke
Ventricular Premature Complexes/surgery
*ablation
*stroke
*tachycardia, ventricular
*ventricular premature complexes
LA - eng
N1 - 1524-4539
Zei, Paul C
Vora, Nirali
Comment
Editorial
United States
Circulation. 2017 Feb 28;135(9):878-880. doi: 10.1161/CIRCULATIONAHA.117.026982.
PY - 2017
SN - 0009-7322
SP - 878-880
ST - The Sound of Silence: How Much Noise Should We Make About Postablation Silent
Strokes?
T2 - Circulation
TI - The Sound of Silence: How Much Noise Should We Make About Postablation Silent
Strokes?
VL - 135
ID - 2619
ER -
TY - JOUR
AB - OBJECTIVE: To explore the prevalence, distribution type and impact of atrial
fibrillation on prognosis of hospitalized patients with congestive heart failure
(CHF) with left ventricular ejection fraction (LVEF)>or=0.50. METHODS: The medical
records of 417 unselected consecutive patients with CHF were retrospectively
reviewed. Patients were categorized as LVEF<0.50 or LVEF>or=0.50. And they were
also categorized by the past history of atrial fibrillation and divided into three
groups: paroxysmal atrial fibrillation, continuous atrial fibrillation and onset of
atrial fibrillation after admission. Then the vicious events, the number of
readmission due to CHF and the interval between discharge and readmission were
observed and recorded. RESULTS: Male patients were prevalent with CHF whose
LVEF<0.50. The occurrence of acute myocardial infarction in the 1st year [15.6%
(34/218)] was higher than that of CHF with LVEF>or=0.5 [8.0% (16/199), P<0.01]. The
occurrence of cerebral stroke in patients with atrial fibrillation [24.3% (27/111)]
was higher than that of patients without atrial fibrillation [8.4% (9/107),
P<0.05). The numbers of acute coronary syndrome and cardiac death were also
increased. In the patients with CHF whose LVEF>or=0.50 the incidence atrial
fibrillation occurring after readmission was significantly higher than that of
patient with CHF whose LVEF<0.50 (51 vs. 30, P<0.05). Atrial fibrillation could be
found in nearly 2/3 of patients. And the number of readmission (2.78+/-1.79 vs.
2.00+/-1.35, P<0.01) was increased, while the interval between discharge and
readmission [(117+/-107) days vs. (154+/-130) days, P<0.05] was shorter.
CONCLUSION: Atrial fibrillation occurs more likely in patients with CHF whose
LVEF>or=0.50, leading to a shorter interval of readmission. Therefore the
importance of treatment of atrial fibrillation should be emphasized.
AD - Department of Emergency, The 1st Affiliated Hospital of Sun Yet-Sen
University, China. wenzhan@pub.guangzhou.gd.cn
AN - 18419950
AU - Zhan, H.
AU - Tse, H. F.
AU - Cao, J. M.
AU - Lau, C. P.
DA - Apr
DP - NLM
ET - 2008/04/19
IS - 4
J2 - Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine =
Zhongguo weizhongbing jijiuyixue
KW - Adult
Aged
Aged, 80 and over
Female
Humans
Male
Middle Aged
Prevalence
Prognosis
*Stroke Volume
LA - chi
N1 - Zhan, Hong
Tse, Hung-fat
Cao, Jiang-ming
Lau, Cpu-pak
English Abstract
Journal Article
China
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2008 Apr;20(4):200-3.
PY - 2008
SN - 1003-0603 (Print)
1003-0603
SP - 200-3
ST - [Impact of atrial fibrillation on prognosis of chronic heart failure patients
with left ventricular ejection fraction>or=0.5]
T2 - Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
TI - [Impact of atrial fibrillation on prognosis of chronic heart failure patients
with left ventricular ejection fraction>or=0.5]
VL - 20
ID - 2921
ER -
TY - JOUR
AB - The present study aimed to investigate the in-hospital and long-term
prognostic value of fragmented QRS complex (fQRS) for microvascular reperfusion and
changes in left ventricular (LV) function in patients with ST elevation myocardial
infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI).
A total of 216 patients with STEMI undergoing primary PCI were included in the
current study. Patients were divided into two groups based on the presence (n=126)
or absence (n=90) of fQRS following electrocardiograms (ECGs) on admission.
Following primary PCI and follow up, patients were divided into four groups based
on new onset, resolution, persistence and absence of fQRS. Major adverse cardiac
events were defined to include cardiovascular death, arrhythmia, heart failure,
reinfarction and target vessel revascularization. The percentage of patients with
heart failure and microvascular reperfusion differed significantly between the
fQRS(+) and fQRS(-) groups. Levels of N-terminal pro-brain natriuretic peptide (NT-
proBNP), Peak creatine kinase-MB (CK-MB) and Troponin I levels were observed to be
significantly higher in the fQRS(+) group compared with the fQRS(-) group. In
univariate logistic regression analysis, left ventricular ejection fraction (LVEF),
NT-proBNP, Troponin I, Peak CK-MB and microvascular reperfusion were found to be
associated with fQRS. Multivariate analysis identified that LVEF, NT-proBNP,
Troponin I and microvascular reperfusion may be independent predictors of fQRS. The
presence of fQRS was demonstrated to be associated with left ventricular
dysfunction at follow up assessments. The presence of fQRS was not only
significantly associated with myocardial microvascular reperfusion and left
ventricular function, but was also a prognostic marker in STEMI.
AD - Department of Cardiology, The 2nd Affiliated Hospital of Harbin Medical
University, Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education,
Harbin, Heilongjiang 150086, P.R. China.
AN - 28588675
AU - Zhang, R.
AU - Chen, S.
AU - Zhao, Q.
AU - Sun, M.
AU - Yu, B.
AU - Hou, J.
C2 - PMC5450773
DA - Jun
DO - 10.3892/etm.2017.4380
DP - NLM
ET - 2017/06/08
IS - 6
J2 - Experimental and therapeutic medicine
KW - ST elevation myocardial infarction
fragmented QRS
left ventricular function
myocardial microvascular reperfusion
primary percutaneous coronary intervention
LA - eng
N1 - 1792-1015
Zhang, Ruoxi
Chen, Shuyuan
Zhao, Qi
Sun, Meng
Yu, Bo
Hou, Jingbo
Journal Article
Exp Ther Med. 2017 Jun;13(6):3231-3238. doi: 10.3892/etm.2017.4380. Epub 2017 Apr
25.
PY - 2017
SN - 1792-0981 (Print)
1792-0981
SP - 3231-3238
ST - Fragmented QRS complex is a prognostic marker of microvascular reperfusion
and changes in LV function occur in patients with ST elevation myocardial
infarction who underwent primary percutaneous coronary intervention
T2 - Exp Ther Med
TI - Fragmented QRS complex is a prognostic marker of microvascular reperfusion
and changes in LV function occur in patients with ST elevation myocardial
infarction who underwent primary percutaneous coronary intervention
VL - 13
ID - 3099
ER -
TY - JOUR
AB - OBJECTIVE: This study was performed to detect the phosphorylation state of
Cx43 in human left ventricular myocardium among sudden deaths caused by acute
myocardial ischemia (AMI) especially sudden coronary death (SCD) and control
groups. And then evaluate the significance of these findings in diagnosing the
early pathological changes of acute myocardial ischemia. METHODS:
Immunohistochemistry (IHC) SP techniques were adopted to detect the phosphorylation
state of Cx43 in the left ventricular myocardium samples of 45 deceased, which
classified as group I--SCD, group II & III (other two groups of AMI) and Group IV &
V (two control groups, sudden death caused by lethal acute cranio-cerebral injury
or pathologic intracranial hemorrhage). In addition, we selected anti-Pan-Cadherin
(construction protein of adherent junctions on the intercalated disc) and PHA-
E+L/Bio, to detect the integration of myocardial mechanical coupling and membranes
(applying affinityhistochemistry, AHC) respectively. RESULTS: (1) Phosphorylated
Cx43 positive staining was almost invisible in Group I, II and III or scattered in
sarcoplasm in few samples; but it was assembling at the IDs clearly in group IV and
V. (2) Strongly positive staining of Pan-Cadherin could be observed at the IDs and
(3) integrated myocardial membranes were found in all samples. CONCLUSION: These
findings suggested that compared with the control groups, the integration of
myocardial mechanical coupling and membranes did not alter in AMI. But Cx43, the
key protein of electrical coupling on myocardial gap junctions, occurred
dephosphorylation remarkably in AMI. Thus applying IHC techniques to detect the
Cx43 dephosphorylation in human left ventricular myocardium maybe useful to
recognize the onset of arrhythmia in AMI, especially in SCD whose myocardium
without apparent morphological changes.
AD - Department of Forensic Medicine, Tongji Medical College of Huazhong
University of Science and Technology, Wuhan 430030, China. seaway_zhang@hotmail.com
AN - 15495803
AU - Zhang, S. W.
AU - Liu, S. X.
AU - Deng, L. B.
DP - NLM
ET - 2004/10/22
IS - 3
J2 - Fa yi xue za zhi
KW - Acute Disease
Adolescent
Adult
Aged
Connexin 43/*metabolism
Death, Sudden, Cardiac/pathology
Female
Gap Junctions/metabolism
Heart Ventricles/*metabolism/pathology
Humans
Immunohistochemistry
Male
Middle Aged
Myocardial Ischemia/*metabolism/pathology
Myocardium/*metabolism/pathology/ultrastructure
LA - chi
N1 - Zhang, Shi-wei
Liu, Shi-xin
Deng, Li-bin
English Abstract
Journal Article
China
Fa Yi Xue Za Zhi. 2004;20(3):136-9, 142.
PY - 2004
SN - 1004-5619 (Print)
1004-5619
SP - 136-9, 142
ST - [Immunohistochemical study of Cx43 dephosphorylation in human left
ventricular myocardium suffered by acute ischemia]
T2 - Fa Yi Xue Za Zhi
TI - [Immunohistochemical study of Cx43 dephosphorylation in human left
ventricular myocardium suffered by acute ischemia]
VL - 20
ID - 2906
ER -
TY - JOUR
AB - The effects of atrial fibrillation on complications and prognosis of patients
receiving emergency percutaneous coronary intervention after acute myocardial
infarction (AMI) were investigated. Eighty AMI patients treated with interventional
vascular recanalization in the Affiliated Hospital of Weifang Medical University
(Weifang, China) from July 2015 to October 2016 were selected, including 40
patients complicated with atrial fibrillation before operation (control group) and
40 patients without atrial fibrillation before operation (observation group). The
systolic blood pressure, diastolic blood pressure, heart rate, arrhythmia and
common complications after MI were compared. Changes in the coronary artery
thrombolysis in myocardial infarction (TIMI) flow grade and left ventricular
ejection fraction (LVEF) of patients were also recorded. Moreover, changes in brain
natriuretic peptide (BNP) levels were compared. The recovery time of myocardial
enzyme and total troponin in both groups was recorded. The systolic and diastolic
blood pressure in the observation group were significantly higher than those in the
control group (p<0.05). During the intervention, the total proportion of patients
with ventricular arrhythmia, atrial arrhythmia, atrioventricular block and sinus
tachycardia in the observation group was significantly lower than that in the
control group (p<0.05). The total proportion of common complications after MI in
the observation group was obviously lower than that in the control group (p<0.05).
Coronary artery TIMI flow grades and LVEFs in the observation group were obviously
higher than those in the control group. BNP levels in the observation group were
significantly lower than those in the control group. The recovery time of
myocardial enzyme and total troponin in the observation group was significantly
earlier than that in the control group. Atrial fibrillation has a certain negative
effect on the circulatory function in patients with AMI after the interventional
therapy, and the proportions of arrhythmia and complications in patients after MI
are increased at the same time, so the postoperative recovery of patients is slow
with many complications.
AD - Department of Emergency, Affiliated Hospital of Weifang Medical University,
Weifang, Shandong 261031, P.R. China.
Department of Stomatology, Affiliated Hospital of Weifang Medical University,
Department of Public Health, Affiliated Hospital of Weifang Medical University,
AN - 30233710
AU - Zhang, Y.
AU - Zhang, L.
AU - Zheng, H.
AU - Chen, H.
C2 - PMC6143848
DA - Oct
DO - 10.3892/etm.2018.6640
DP - NLM
ET - 2018/09/21
IS - 4
J2 - Experimental and therapeutic medicine
KW - acute myocardial infarction
atrial fibrillation
complications
LA - eng
N1 - 1792-1015
Zhang, Yingchun
Zhang, Lingzhi
Zheng, Hongzhi
Chen, Hongfen
Journal Article
Exp Ther Med. 2018 Oct;16(4):3574-3578. doi: 10.3892/etm.2018.6640. Epub 2018 Aug
22.
PY - 2018
SN - 1792-0981 (Print)
1792-0981
SP - 3574-3578
ST - Effects of atrial fibrillation on complications and prognosis of patients
receiving emergency PCI after acute myocardial infarction
T2 - Exp Ther Med
TI - Effects of atrial fibrillation on complications and prognosis of patients
receiving emergency PCI after acute myocardial infarction
VL - 16
ID - 3084
ER -
TY - JOUR
AB - BACKGROUND: Coronary artery disease accelerates heart failure progression,
leading to poor prognosis and a substantial increase in morbidity and mortality.
This study was aimed to assess the impact of coronary artery disease on all-cause
mortality, myocardial infarction (MI), and ischemic stroke (IS) among hospitalized
newly-diagnosed heart failure (HF) patients with left ventricular systolic
dysfunction (LVSD). METHODS: This retrospective cohort study included Medicare
patients (aged ≥65 years) with ≥1 inpatient heart failure claim (index date =
discharge date) during 01JAN2007-31DEC2013. Patients were required to have
continuous enrollment for ≥1-year pre-index date (baseline: 1-year pre-index
period) without a prior heart failure claim (in the 1 year pre-index prior to the
index hospital admission); follow-up ran from the index date to death,
disenrollment from the health plan, or the end of the study period, whichever
occurred first. HF with LVSD patients, identified with diagnosis codes of systolic
dysfunction (excluding baseline atrial fibrillation), were stratified based on
prevalent coronary artery disease at baseline into coronary artery disease and non-
coronary artery disease cohorts. Main outcomes were occurrence of major adverse
cardiovascular events including all-cause mortality, myocardial infarction, and
ischemic stroke. Propensity score matching (PSM) was used to balance patient
characteristics. Kaplan-Meier curves of ACM and cumulative incidence distribution
of MI/IS were presented. RESULTS: Of 22,230 HF with LVSD patients, 15,827 (71.2%)
had coronary artery disease and were overall more likely to be younger (79.8 vs
80.9 years), male (49.6% vs. 35.6%), white (86.2% vs 81.4%), with more prevalent
comorbidities including hypertension (80.7% vs 74.3%), hyperlipidemia (67.7% vs
46.7%), and diabetes (46.3% vs 35.8%) (all p < 0.0001). After propensity score
matching, cohorts included 5792 patients each. The coronary artery disease cohort
had significantly higher cumulative incidence of myocardial infarction and ischemic
stroke at the end of 7-year follow-up vs non-coronary artery disease (myocardial
infarction = 50.0% vs 18.0%; ischemic stroke = 23.3% vs 18.7%; all p < 0.0001).
Follow-up all-cause mortality rates were similar between the two cohorts.
CONCLUSIONS: HF with LVSD patients with coronary artery disease had significantly
higher incidence of ischemic stroke and myocardial infarction, but similar all-
cause mortality compared to those without coronary artery disease.
AD - Janssen Scientific Affairs, LLC, Titusville, NJ, USA.
STATinMED Research, Plano, TX, USA. lwang@statinmed.com.
Columbia University, New York, NY, USA.
Janssen Scientific Affairs, LLC, Titusville, NJ, USA. scheinjeff@gmail.com.
The University of Michigan, Ann Arbor, MI, USA.
New York University School of Medicine, New York, NY, USA.
AN - 30646855
AU - Zhao, Q.
AU - Wang, L.
AU - Kurlansky, P. A.
AU - Schein, J.
AU - Baser, O.
AU - Berger, J. S.
C2 - PMC6334438
DA - Jan 15
DO - 10.1186/s12872-018-0991-1
DP - NLM
ET - 2019/01/17
IS - 1
KW - Age Factors
Aged
Aged, 80 and over
Atrial Fibrillation/diagnosis/*mortality/physiopathology
Brain Ischemia/diagnosis/*mortality/physiopathology
Cause of Death
Comorbidity
Coronary Artery Disease/diagnosis/*mortality/physiopathology
Databases, Factual
Female
Heart Failure/diagnosis/*mortality/physiopathology
Humans
Incidence
Male
Medicare
Prevalence
Prognosis
Risk Assessment
Risk Factors
Stroke/diagnosis/*mortality/physiopathology
Time Factors
Ventricular Dysfunction, Left/diagnosis/*mortality/physiopathology
*Coronary artery disease
*Ischemic stroke
*Mortality
*Myocardial infarction
were disclosed for the purposes of this study. Since the data used for this study
were de-identified and only aggregate results were reported, the study was approved
by the Institutional Review Board as exempt. Compliance with all applicable laws
and
the Health Insurance Portability and Accountability Act (HIPAA) regulations were
maintained. CONSENT FOR PUBLICATION: Since all patient data were deidentified,
patient consent was not required. COMPETING INTERESTS: QZ is a paid employee of
Janssen Scientific Affairs, LLC
LW is a paid employee of STATinMED Research which
provides consulting services to Janssen Scientific Affairs, LLC
JS is a paid
employee of Janssen Scientific Affairs, LLC
OB is a paid employee of STATinMED
Research which provides consulting service to Janssen Scientific Affairs, LLC
PAK
and JSB have no conflicts to declare. PUBLISHER’S NOTE: Springer Nature remains
neutral with regard to jurisdictional claims in published maps and institutional
affiliations.
LA - eng
N1 - 1471-2261
Zhao, Qi
Wang, Li
Orcid: 0000-0002-6157-9023
Kurlansky, Paul A
Schein, Jeff
Baser, Onur
Berger, Jeffrey S
Journal Article
BMC Cardiovasc Disord. 2019 Jan 15;19(1):19. doi: 10.1186/s12872-018-0991-1.
PY - 2019
SN - 1471-2261
SP - 19
ST - Cardiovascular outcomes among elderly patients with heart failure and
coronary artery disease and without atrial fibrillation: a retrospective cohort
study
TI - Cardiovascular outcomes among elderly patients with heart failure and
coronary artery disease and without atrial fibrillation: a retrospective cohort
study
VL - 19
ID - 2343
ER -
TY - JOUR
AB - Open heart surgery without cross clamping aorta under normothermic or
hypothermic cardiopulmonary bypass was performed in 167 patients in which there
were more than ten kinds of cardiac diseases. The characteristics of the procedure
included only vena cava blocked and aorta unclamped with beating heart or
artificial evoked ventricular fibrillation. It diminished myocardial ischemia and
reperfusion injuries maximally. There were no low cardiac output syndrome, severe
arrhythmia and complications of brain except two patients died postoperatively. The
operative mortality rate was 1.1% (2/167). The advantages, disadvantages and safety
of this method are discussed briefly in this paper.
AD - Department of Cardiovascular Thoracic Surgery, Second Affiliated Hospital,
Hunan Medical University, Changsha.
AN - 10681828
AU - Zhou, X.
AU - Hu, J.
AU - Yin, B.
AU - Li, J.
AU - Zhang, W.
DP - NLM
ET - 2000/02/22
IS - 2
J2 - Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan
Medical University
KW - Adolescent
Adult
*Cardiopulmonary Bypass/methods
Child
Child, Preschool
Female
Heart Septal Defects, Atrial/*surgery
Humans
Infant
Male
Middle Aged
LA - chi
N1 - Zhou, X
Hu, J
Yin, B
Li, J
Zhang, W
English Abstract
Journal Article
China
Hunan Yi Ke Da Xue Xue Bao. 1998;23(2):146-8.
PY - 1998
SN - 1000-5625 (Print)
1000-5625
SP - 146-8
ST - [Open heart surgery without cross clamping aorta]
T2 - Hunan Yi Ke Da Xue Xue Bao
TI - [Open heart surgery without cross clamping aorta]
VL - 23
ID - 3073
ER -
TY - JOUR
AB - BACKGROUND: Sleep apnoea hypopnoea syndrome (SAHS) is characterised by
repetitive nocturnal hypoxemia and has a high prevalence among patients with acute
myocardial infarction (AMI). But there are few studies on patients with AMI
undergoing emergency primary percutaneous coronary intervention (pPCI). In this
study, we want to find the prevalence of SAHS among patients with AMI undergoing
emergency pPCI and determine whether SAHS would worsen the condition among these
people, and especially affect the damage degree of the coronary artery. METHODS:
Over four months, 95 patients admitted for the first time for AMI were observed.
All of them had emergency primary PCIs. A total of 86 patients accepted the sleep
study and were divided into four groups according to the apnoea hypopnoea index
(AHI): SAHS was diagnosed when AHI ≥5/h and was defined as mild for AHI ≥5/h and
<15/h, moderate for AHI ≥15/h and <30/h, and severe for AHI ≥30/h. On the contrary,
the patients whose AHI <5/h were Non-SAHS. And the characteristics of the patients
among these four groups were compared. According to the time of chest pain onset,
the number of the patients between SAHS and non-SAHS, and patients' AHI during
three intervals of one day were measured and compared; Makers including the
sensitivity of serum troponin T (hs-TnT), creatine kinase isoenzyme MB (CK-MB),
left ventricular ejection fraction (LVEF), pro-brain-type natriuretic peptide (pro-
BNP), Gensini score and collateral vessels between the SAHS and non-SAHS were
compared. And the relationships between the AHI of these patients and the markers
were analysed. RESULTS: Of the 86 patients studied, 65 had SAHS, representing a
SAHS prevalence of 75.58% among patients with AMI undergoing emergency pPCI. There
were significant differences in average ages, smoking and arrhythmia (P<0.05)
between these four groups. There was no significant difference between AMI patients
with or without SAHS regarding the day-night pattern. But there showed significant
differences between SAHS and non-SAHS in Gensini score (P<0.05) and pro-BNP
(P<0.05). Also, there were positive correlations between AHI and Gensini score
(r=0.490, P<0.05) and pro-BNP (r=0.338, P<0.05). CONCLUSIONS: Among patients with
AMI undergoing emergency pPCI, there is a high prevalence of SAHS. There are also
positive correlations between AHI and Gensini score, and pro-BNP. Therefore, guided
by the results, should we conduct a routine screening to those patients normally
and could we relieve the damage to the coronary artery by curing the SAHS?
AD - Department of Sleep Medicine Center, Nanfang Hospital, Southern Medical
University, Guangzhou 510515, China.
AN - 28932553
AU - Zhu, C. P.
AU - Li, T. P.
AU - Wang, X.
AU - Zhao, Y. H.
AU - Zhou, S. X.
AU - Fu, Y.
AU - Jiang, Y. W.
AU - Xiao, X. P.
C2 - PMC5594170
DA - Aug
DO - 10.21037/jtd.2017.07.50
DP - NLM
ET - 2017/09/22
IS - 8
J2 - Journal of thoracic disease
KW - Gensini score
Sleep apnoea hypopnoea syndrome (SAHS)
acute myocardial infarction (AMI)
emergency primary percutaneous coronary intervention (emergency pPCI)
LA - eng
N1 - 2077-6624
Zhu, Cai-Ping
Li, Tao-Ping
Wang, Xiao
Zhao, Yu-Hua
Zhou, Shi-Xi
Fu, Yan
Jiang, Yi-Wei
Xiao, Xue-Ping
Journal Article
J Thorac Dis. 2017 Aug;9(8):2476-2483. doi: 10.21037/jtd.2017.07.50.
PY - 2017
SN - 2072-1439 (Print)
2072-1439
SP - 2476-2483
ST - The relationship between apnoea hypopnoea index and Gensini score in patients
with acute myocardial infarction undergoing emergency primary percutaneous coronary
intervention
T2 - J Thorac Dis
TI - The relationship between apnoea hypopnoea index and Gensini score in patients
with acute myocardial infarction undergoing emergency primary percutaneous coronary
intervention
VL - 9
ID - 3136
ER -
TY - JOUR
AB - Episodes of acute emotional stress can have significant adverse effects on
the heart. Acute emotional stress can produce left ventricular contractile
dysfunction, myocardial ischemia, or disturbances of cardiac rhythm. Although these
abnormalities are often only transient, their consequences can be gravely damaging
and sometimes fatal. Despite the many descriptions of catastrophic cardiovascular
events in the setting of acute emotional stress, the anatomical substrate and
physiological pathways by which emotional stress triggers cardiovascular events are
only now being characterized, aided by the advent of functional neuroimaging.
Recent evidence indicates that asymmetric brain activity is particularly important
in making the heart more susceptible to ventricular arrhythmias. Lateralization of
cerebral activity during emotional stress may stimulate the heart asymmetrically
and produce areas of inhomogeneous repolarization that create electrical
instability and facilitate the development of cardiac arrhythmias. Patients with
ischemic heart disease who survive an episode of sudden cardiac death in the
setting of acute emotional stress should receive a beta-blocker. Nonpharmacological
approaches to manage emotional stress in patients with and without coronary artery
disease, including social support, relaxation therapy, yoga, meditation, controlled
slow breathing, and biofeedback, are also appropriate to consider and merit
additional investigation in randomized trials.
AD - Department of Medicine, Johns Hopkins University School of Medicine and
Division of Cardiology, Johns Hopkins Bayview Medical Center, Baltimore, Maryland
21224-2780, USA. rziegel@jhmi.edu
AN - 17635893
AU - Ziegelstein, R. C.
DA - Jul 18
DO - 10.1001/jama.298.3.324
DP - NLM
ET - 2007/07/20
IS - 3
J2 - Jama
KW - Acute Disease
Aged
Arrhythmias, Cardiac/*etiology/*prevention & control
Female
Humans
Male
Middle Aged
Parasympathetic Nervous System/physiology
Stress, Psychological/*complications/physiopathology/*prevention & control
Sympathetic Nervous System/physiology
LA - eng
N1 - 1538-3598
Ziegelstein, Roy C
Case Reports
Clinical Conference
Journal Article
United States
JAMA. 2007 Jul 18;298(3):324-9. doi: 10.1001/jama.298.3.324.
PY - 2007
SN - 0098-7484
SP - 324-9
ST - Acute emotional stress and cardiac arrhythmias
T2 - Jama
TI - Acute emotional stress and cardiac arrhythmias
VL - 298
ID - 2482
ER -
TY - JOUR
AN - 22189818
AU - Zini, A.
AU - Fioravanti, V.
AU - Ferraro, D.
AU - Casoni, F.
AU - Cavazzuti, M.
AU - Nichelli, P.
DA - Dec
DO - 10.2459/JCM.0b013e32834f241d
DP - NLM
ET - 2011/12/23
IS - 12
KW - Aged
Cerebral Cortex/*blood supply/physiopathology
Electrocardiography
Heart/*innervation
Humans
Male
Stroke/*complications/diagnosis
Tachycardia, Paroxysmal/diagnosis/*etiology/physiopathology
Tachycardia, Ventricular/diagnosis/*etiology/physiopathology
LA - eng
N1 - 1558-2035
Zini, Andrea
Fioravanti, Valentina
Ferraro, Diana
Casoni, Federica
Cavazzuti, Milena
Nichelli, Paolo
Case Reports
Letter
United States
J Cardiovasc Med (Hagerstown). 2012 Dec;13(12):842-3. doi:
10.2459/JCM.0b013e32834f241d.
PY - 2012
SN - 1558-2027
SP - 842-3
ST - Paroxysmal ventricular tachicardia and pure right insular stroke
TI - Paroxysmal ventricular tachicardia and pure right insular stroke
VL - 13
ID - 2712
ER -
TY - JOUR
AB - There are complex and dynamic reflex control networks between the heart and
the brain, including cardiac and intrathoracic ganglia, spinal cord, brainstem, and
central nucleus. Recent literature based on animal model and clinical trials
indicates a close link between cardiac function and nervous systems. It is
noteworthy that the autonomic nervous-based therapeutics has shown great potential
in the management of atrial fibrillation, ventricular arrhythmia, and myocardial
remodeling. However, the potential mechanisms of postoperative brain injury and
cardiovascular changes, particularly heart rate variability and the presence of
arrhythmias, are not understood. In this chapter, we will describe mechanisms of
brain damage undergoing cardiac surgery and focus on the interaction between
cardiovascular changes and damage to specific brain regions.
AD - Department of Cardiovascular Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-
sen University, Guangzhou 510120, China.
Department of Gastroenterology, The Fifth Affiliated Hospital, Sun Yat-sen
University, Zhuhai 519000, China.
The Biobank of Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou
510120, China.
Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, UK.
Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School
of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
AN - 28758117
AU - Zou, R.
AU - Shi, W.
AU - Tao, J.
AU - Li, H.
AU - Lin, X.
AU - Yang, S.
AU - Hua, P.
C2 - PMC5512017
DO - 10.1155/2017/5646348
DP - NLM
ET - 2017/08/02
J2 - BioMed research international
KW - Animals
*Atrial Fibrillation/complications/physiopathology/therapy
*Brain Infarction/etiology/physiopathology/therapy
Heart Rate
Humans
LA - eng
N1 - 2314-6141
Zou, Rongjun
Shi, Wanting
Tao, Jun
Li, Hongmu
Lin, Xifeng
Yang, Songran
Orcid: 0000-0002-2490-7091
Hua, Ping
Orcid: 0000-0001-9559-8065
Journal Article
Review
Biomed Res Int. 2017;2017:5646348. doi: 10.1155/2017/5646348. Epub 2017 Jul 3.
PY - 2017
SN - 2314-6133 (Print)
SP - 5646348
ST - Neurocardiology: Cardiovascular Changes and Specific Brain Region Infarcts
T2 - Biomed Res Int
TI - Neurocardiology: Cardiovascular Changes and Specific Brain Region Infarcts
VL - 2017
ID - 2327
ER -
TY - JOUR
AB - OBJECTIVE: To assess the prevalence and the characteristics of silent
myocardial ischaemia (SMI) and ventricular arrhythmias (VA) in subjects with
Alzheimer's disease (AD) and mild cognitive impairment (MCI) and their
relationships with QT interval dispersion (QTD). METHODS: Thirty-three subjects
with AD, 39 subjects with MCI, and 29 cognitive healthy control subjects matched
for demographic characteristics, hypertensive condition, smoking habits, and
laboratory parameters were enrolled. Each subject underwent clinical and cognitive
examination, a structural brain imaging study, electrocardiogram (ECG), 24-h ECG
recording, 24-h blood pressure monitoring, and echocardiogram. Detection and
characterization of QT dispersion, SMI and VA were performed. RESULTS: The three
groups were comparable regarding demographic and basal cardiovascular
characteristics: notwithstanding this, SMI episodes were observed only in AD and
MCI patients (19 and 14, respectively). A significantly greater prevalence of
repetitive ventricular premature beats was observed in AD (mean 8.56+/-13.1) and in
MCI (1.8+/-7.2) vs. control (0.7+/-1.7). The QTD, the ischaemic burden and the
number of repetitive ventricular beats revealed to be significantly related.
CONCLUSIONS: Increased prevalence of SMI and potentially ominous VA were found in
AD and, to a lesser extent, in MCI. SMI and repetitive VA were significantly
related with QTD. These findings could be related to an increased risk of sudden
cardiac death in AD and MCI patients.
AD - Institute of Internal Medicine, Department of Medical Sciences, University of
Brescia, Brescia, Italy. rzulli@libero.it
AN - 18585852
AU - Zulli, R.
AU - Nicosia, F.
AU - Borroni, B.
AU - Agosti, C.
AU - Prometti, P.
AU - Donati, P.
AU - De Vecchi, M.
AU - Turini, D.
AU - Romanelli, G.
AU - Grassi, V.
AU - Padovani, A.
DA - Sep
DO - 10.1016/j.clineuro.2008.05.002
DP - NLM
ET - 2008/07/01
IS - 8
J2 - Clinical neurology and neurosurgery
KW - Aged
Alzheimer Disease/*complications/epidemiology/mortality
Arrhythmias, Cardiac/complications/*epidemiology/mortality
Blood Pressure Monitoring, Ambulatory
Cognition Disorders/*complications/epidemiology/mortality
Coronary Artery Disease/complications/mortality
Echocardiography
Electrocardiography
Female
Humans
Male
Myocardial Ischemia/complications/*epidemiology/mortality
Psychiatric Status Rating Scales
LA - eng
N1 - Zulli, Roberto
Nicosia, Franco
Borroni, Barbara
Agosti, Chiara
Prometti, Paola
Donati, Paolo
De Vecchi, Massimiliano
Turini, Daniele
Romanelli, Giuseppe
Grassi, Vittorio
Padovani, Alessandro
Journal Article
Netherlands
Clin Neurol Neurosurg. 2008 Sep;110(8):791-6. doi: 10.1016/j.clineuro.2008.05.002.
Epub 2008 Jun 27.
PY - 2008
SN - 0303-8467 (Print)
0303-8467
SP - 791-6
ST - Increased prevalence of silent myocardial ischaemia and severe ventricular
arrhythmias in untreated patients with Alzheimer's disease and mild cognitive
impairment without overt coronary artery disease
T2 - Clin Neurol Neurosurg
TI - Increased prevalence of silent myocardial ischaemia and severe ventricular
arrhythmias in untreated patients with Alzheimer's disease and mild cognitive
impairment without overt coronary artery disease
VL - 110
ID - 2840
ER -

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