Rabbits: Peter Fisher - Jennifer Graham

Chapter 10 Rabbits
Peter Fisher | Jennifer Graham
494
C HA PT E R 10 Rabbits 495
TA BLE 10-1 Antimicrobial Agents Used in Rabbits.a
Agent Dosage Comments

Amikacin 5-10 mg/kg SC, IM,
IV divided q8-24h41
8-16 mg/kg SC, IM, IV q24h112 Increased efficacy and decreased toxicity when
given once daily; for IV use, dilute in 4 mL/kg
saline and give over 20 min
1.25 g/20 g Place in bone after surgical debridement
methylmethacrylate41 of jaw abscess
Azithromycin 4-5 mg/kg IM q48h 7 days19 Effective against syphilis
15-30 mg/kg PO PD; pulmonary infections
q24h 15 days41
Cefazolin 2 g/20 g methylmethacrylate41 Place in bone after surgical debridement
of jaw abscess
Cefotaxime 50 mg/kg IM q8h41 Pneumococcal endocarditis
Ceftazidime 50 mg/kg IM, IV q3h1 PK
100 mg/kg IM q12h41
Ceftiofur 2 g/20 g methylmethacrylate41 Place in bone after surgical debridement
of jaw abscess
Ceftriaxone 40 mg/kg IM Effective against syphilis,
q12h 2-3 days41 pneumococcal endocarditis
71 mg/kg IV q24h28 Pneumococcal pneumonia
Cephalexin — Oral cephalosporins are not recommended41
15 mg/kg SC q12h41 Parenteral form not available in the United States;
not generally recommended
Cephalothin 12.5 mg/kg IM q6h 6 days41 Cephalosporins are generally not
recommended;112 not available in the
United States
2 g/20 g methylmethacrylate41 Place in bone after surgical debridement
of jaw abscess
Chloramphenicol — The use of chloramphenicol in food-producing
animals is prohibited in the United States
25 mg/kg PO q8-12h41
30-50 mg/kg SC, IM, IV
q8-24h41,112
55 mg/kg PO q12h 4 wk41 Effective against syphilis
Chlortetracycline 50 mg/kg PO q24h41
Ciprofloxacinb — May cause arthropathies in young animals126
41
5-20 mg/kg PO q12h Suspension in water is stable for 14 days
1 drop topical q8-12h53 Nasal pasteurellosis; maintains therapeutic levels
in tear film for at least 6hr after application
(tears drain into nasal sinus)
Difloxacinb (Dicural, 5 mg/kg IM, IV q24h3 PK; dose appropriate for E. coli infections
Fort Dodge)
Doxycycline 2.5 mg/kg PO q12h20
4 mg/kg PO q24h41
Continued
496 Exotic Animal Formulary
TA BL E 10-1 Antimicrobial Agents Used in Rabbits. (cont’d)

Enrofloxacin b
— May cause arthropathies in young dogs, but
similar effects using standard dosages in rabbits
have not been reported; SC and IM injections may
cause muscle necrosis or sterile abscesses;
dilute before giving parenterally41
5 mg/kg IM, IV q12-24h36 Angora rabbits/PK
5 mg/kg PO, SC, IM, IV PK;15,16 clinical trial for pasteurellosis,
q12h15,16,41 14 days41
5-20 mg/kg PO, IM Pasteurellosis
q12h 14-30 days41
200 mg/L drinking
water 14 days41
Florfenicol — In the United States, use of related drug
chloramphenicol is prohibited in
food-producing animals
25 mg/kg IM, IV q6h74 PK
30 mg/kg PO, IV q8h2 PK
Furazolidone 5 mg/kg PO q24h 14 days41 The FDA has prohibited extra-label use
in food animals
5.5 g/L drinking water41
50 mg/kg feed41
Gentamicin — Seldom indicated; use with caution
4 mg/kg SC, IM q24h41
5-8 mg/kg SC, IM, IV q8-24h41 Decreased toxicity when given once daily; for IV
use, dilute in 4 mL/kg saline and give over
20 min
1 g/20 g methylmethacrylate41 Place in bone after surgical debridement
of jaw abscess
Marbofloxacinb — Lowest MIC of nine antibiotics tested against
bacteria responsible for upper respiratory
infections120
2 mg/kg SC, IM, IV q24h4,92 PK; study during Pasteurella infection4
5 mg/kg PO q24h 10 days 22
PK
Metronidazole 5 mg/kg IV q12h112 Administer slowly
20 mg/kg PO
q12h 3-5 days112
40 mg/kg PO q24h 3 days41
Minocycline 6 mg/kg IV q8h100 PK
b
Moxifloxacin 5 mg/kg PO, IM PK; susceptible infections (some bacteria may
q24h 10 days39 require higher doses)
40 mg/kg IV q12h 2 doses, Bacterial meningitis
then q24h104
Netilmicin 6-8 mg/kg SC, IM, IV q24h41 For IV use, dilute and give over 20 min
(Netromycin, 7 mg/kg IV q12h122 PK; induced renal tubular necrosis in 50%
Schering) of animals
TA BLE 10-1 Antimicrobial Agents Used in Rabbits. (cont’d)

91
Ofloxacinb (Ocuflox, 20 mg/kg SC q8h Urogenital, skin, respiratory infections
Allergan)
Orbifloxacinb 20 mg/kg PO PK
q24h 7-21 days138
Oxytetracycline 15 mg/kg IM q8h94 PK; anorexia and diarrhea at 30 mg/kg IM q8h;
tissue irritation can occur
25 mg/kg SC q24h41
50 mg/kg PO q12h41
1 mg/mL drinking water41
Penicillin G — Do not give any form of penicillin orally to rabbits
Benzathine form 42,000-60,000 U/kg IM q48h41 Benzathine penicillin achieves lower serum levels
than other forms and is effective against only
highly susceptible organisms
42,000-84,000 U/kg SC
q7d 3 wk41
Procaine form 40,000 U/kg IM Rabbit syphilis
q24h 5-7 days41
42,000-84,000 U/kg SC,
IM q24h41
60,000 U/kg IM q8h139 PK
Benzylpenicillin 60,000 U/kg IM q12h64 PK
Rifampin (R) 40 mg/kg PO q12h + (A) Staphylococcus osteomyelitis
(R)/azithromycin (A) 50 mg/kg PO q24h41
Rifampin (R) 40 mg/kg + (C) 80 mg/kg Staphylococcus osteomyelitis
(R)/clarithromycin (C) PO q12h41
Silver sulfadiazine Topical q24h41 Does not cause diarrhea if ingested
cream (Silvadene,
Marion)
Spectinomycin 1 g/L drinking May cause diarrhea in weanling rabbits
water 7 days112
Sulfadimethoxine 10-15 mg/kg PO q12h112
Sulfamethazine 1 mg/mL drinking water41
5-10 g/kg feed41
Sulfaquinoxaline 1 mg/mL drinking water41
0.6 g/kg feed41
Tetracycline 50-100 mg/kg PO q8-12h112
250-1000 mg/L drinking Therapeutic levels not achieved even at
water41 800-1600 mg/L;108 250 mg/L not effective
in clinical trial for pasteurellosis41
Tilmicosin (Micotil, 12.5 mg/kg PO PK
Elanco) q24h 7 days48
25 mg/kg SC once41 Pasteurellosis; use cautiously: at least one rabbit
death and several human deaths have been
reported;20 has been associated with anemia
and leukopenia
Continued
TA BL E 10-1 Antimicrobial Agents Used in Rabbits. (cont’d)

41
Tobramycin 1 g/20 g methylmethacrylate Place in bone after surgical debridement
of jaw abscess
10% in calcium sulfate Biodegradable implants for treatment
pellets99 of osteomyelitis
Trimethoprim/sulfa 15 mg/kg PO q12h41
30 mg/kg PO, SC, IM May cause tissue necrosis when given SC112
q12h41,112
15-30 mg/kg PO q12-24h112
30-48 mg/kg SC q12h112
Tylosin 10 mg/kg PO, SC, IM
q12-24h112
Vancomycin 50 mg/kg IV q8h100 PD
10 mg vancomycin and 50 mg Osteomyelitis; effective locally for 56 days
DL-lactide-co-glycolide
copolymer41
a
There is a potential for antibiotic-induced enterotoxemia following administration of some antimicrobial agents
(see Table 10.15). Appetite and fecal character must be monitored closely during and following therapy.
b
The use of fluoroquinolones in food-producing animals is strictly prohibited in the United States. Do not use these drugs in rabbits
that may be consumed by humans.
TA BL E 10-2 Antifungal Agents Used in Rabbits.a

Albaconazole 5 mg/kg PO q24h98 Cryptococcal meningitis
50 mg/kg PO q24h18 Disseminated Scedosporium prolificans
Amphotericin B — Severe fungal infections; use in combination with
fluconazole;41 potentially nephrotoxic and
hepatotoxic
Desoxycholate 1 mg/kg IV q24h41,112,121
form
Liposomal 5 mg/kg IV q24h110 Invasive aspergillosis
form
Clotrimazole Topical41 Localized dermatophytosis
(Lotrimin,
Bayer)
Fluconazole 5 mg/kg PO q24h98 Cryptococcal meningitis
25-43 mg/kg IV (slow) q12h87,112 Systemic fungal disease
38 mg/kg PO q12h8 Aspergillus keratitis
80 mg/kg PO q24h 21 days41 Coccidioidal meningitis; controlled but did not cure
TA BLE 10-2 Antifungal Agents Used in Rabbits. (cont’d)

Griseofulvin 12.5-25 mg/kg PO Advanced cases of dermatophytosis; decrease
q12-24h 30-45 days41 dose by 50% if using ultra-microsize form
(Gris-PEG, Allergan Herbert), which has better
absorption
15-25 mg/kg PO q24h, or divided At high doses may cause bone marrow
q12h 30 days58 suppression and panleukopenia
Itraconazole 5-10 mg/kg PO q24h 30 days38,58 Dermatophytosis
20-40 mg/kg PO q24h41 Aspergillus pneumonia
40 mg/kg PO q24h107 Invasive aspergillosis
Ketoconazole 10-40 mg/kg PO Dermatophytosis
q24h 14 days38,41
Lime sulfur Topical q5-7d 4 wk41 Dermatophytosis; use with caution
(2%-3%) Topical 1:32 dilution with water
2 /wk58
Micafungin 0.25-2 mg/kg IV q24h110 Systemic candidiasis
Miconazole Topical q24h 14-28 days41 Localized dermatophytosis
(Conofite,
Merck)
Miconazole/ Bathe once daily65 Dermatophytosis
chlorhexidine
shampoo
Nystatin 20 mg/kg PO q12h 10 days41 Cyniclomyces guttulatus yeast overgrowth
Posaconazole 6 mg/kg PO q24h109 Aspergillus pneumonia
20 mg/kg PO q24h41 Aspergillus pneumonia
Terbinafine — Best used as part of combination therapy; little
activity when used as a single agent41,73
10 mg/kg PO q24h58 Dermatophytosis
100 mg/kg PO q12h 21 days41 Less effective than fluconazole for coccidioidal
meningitis
100 mg/kg PO q12-24h41
100 mg/kg PO q24h in combination Invasive aspergillosis
with amphotericin B 0.4 mg/kg IV
q24h73
Voriconazole — The short terminal elimination half-life of less than
1 hr in the rabbit indicates that the efficacy of
voriconazole is less than optimal in this
species;117 however, voriconazole is effective as a
topical antifungal ophthalmic preparation in the
rabbit (see Table 10.6)
a
Antifungal protocols using amphotericin B administered intravenously or itraconazole, fluconazole, or ketoconazole
administered orally alone or in combination for deep mycotic infections have been based on those used successfully in the
dog and may be adequate treatment options in the rabbit; however, this hypothesis requires confirmation and validation.14
Certain antifungal protocols have not caused death in rabbit models, even when given for extended periods.18,41,107,109,110,121
TA BL E 10-3 Antiparasitic Agents Used in Rabbits.

Albendazole 7.5-20 mg/kg PO Potential treatment for
q24h41 3-14 days41,112 encephalitozoonosis; use cautiously,
deaths have been reported52
Amprolium (9.6%) 0.5 mL/pint drinking Coccidiosis
water 10 days112
0.625 mL/pint drinking
water 21 days41
Carbaryl powder 5% Topically q7d41 Ectoparasites; use sparingly
Cyromazine 6% (Rearguard, Topically q6-10wk41 Preventative for myiasis
Novartis)
Decoquinate (Deccox, 62.5 ppm in feed41 Coccidiosis
Rhone-Poulenc)
Diclazuril 4 mg/kg SC106
1 ppm in feed41,135 PD; intestinal and hepatic coccidiosis
Doramectin 0.2 mg/kg IM once68,112 Psoroptes mites
0.3 mg/kg SC50 PD
Emodepside 2.1%/ 0.14 mL/kg topically once41 Trichostrongylus colubriformis
praziquantel 8.6%
(Profender, Bayer)
Eprinomectin 0.2-0.3 mg/kg SC once105 Psoroptes mites
2 mg/kg topically once140 Psoroptes mites
Febantel/pyrantel pamoate/ ½ tablet/5 kg PO once41 Use tablet for puppies and small dogs
praziquantel (Drontal Plus, (2-25 lb); effective against nematodes
Bayer) and cestodes
Fenbendazole — On rare occasions, anemia and arteritis
have been reported52
5 mg/kg PO41
5-20 mg/kg PO Nematodes; use 20 mg/kg
q24h 5 days; repeat in for Passalurus ambiguous
14 days41
20 mg/kg PO q24h 7 days Preventive against encephalitozoonosis
before and 2 days after mixing
rabbits130
20 mg/kg PO Treatment for encephalitozoonosis;
q24h 28 days112,130 failed to clear all parasites
50 ppm in feed 2-6 wk41
Fipronil (Frontline, Merial) Contraindicated41 Can cause neurologic disease and death
Imidacloprid (Advantage, 10-16 mg/kg topically Flea adulticide; use single 0.4 mL dose,
Bayer) once41,61 10% solution
Imidacloprid (I) 10%/ 10 mg/kg (I) + 1 mg/kg (M) Psoroptes mites
moxidectin (M) 1% topically q4wk 3
(Advantage Multi for Cats, treatments41
Bayer)
Imidacloprid 8.8%/ 11-16.6 mg/kg topically Leporacarus gibbus (rabbit fur mite)
permethrin 44% once12
(Advantix, Bayer)
TA BLE 10-3 Antiparasitic Agents Used in Rabbits. (cont’d)

Ivermectin — Ectoparasites
0.1-0.2 mg/kg SC, Ear mites, clinical trial
repeat in 14 days41
0.2-0.44 mg/kg PO, Psoroptes (ear mites)
SC q8-14d112
0.3-0.4 mg/kg SC, Sarcoptes scabiei (sarcoptic mange);
repeat in 14 days112 Notoedres cati
0.4 mg/kg SC q80h 3 Sarcoptic mange
doses69
Lasalocid 120 ppm in feed41 Coccidiosis
Lime sulfur (2%-3%) 1-2 dips/wk 28 days41 Ectoparasites; young animals
Dip q7d 4-6 wk41,112
Lufenuron (Program, 30 mg/kg PO q30d112 Flea larvicide
Novartis)
Metronidazole 20 mg/kg PO q12h41 Antiprotozoal agent
Monensin (CoBan 60, 0.002%-0.004% in feed41 Coccidiosis
Elanco)
Moxidectin 0.2 mg/kg PO, repeat in Psoroptic mange
10 days112,136
0.3 mg/kg SC50 PD
Oxibendazole 30 mg/kg PO q24h 7-14 Encephalitozoonosis; no highly effective
days, then 15 mg/kg PO q24h treatment has been identified; bone
for 30-60 days112 marrow suppression has been reported
with the use of benzimidazoles, so an
intratreatment CBC is recommended52
Piperazine 100 mg/kg PO Use with citrate formulation
q24h 2 days41
200 mg/kg PO, repeat in Use with citrate formulation
14-21 days112
200-500 mg/kg Adults; use with adipate formulation
PO 2 days112
750 mg/kg PO 2 days41 Juveniles; wash perianal area
2-5 mg/mL drinking
water 7 days41
Praziquantel 5-10 mg/kg PO, SC, IM, repeat Cestodes, trematodes
in 10 days112
Pyrantel pamoate 5-10 mg/kg PO, SC, IM, repeat
in 10 days41
5-10 mg/kg PO, repeat in
14-21 days112
Pyrethrins Topically as directed for Flea control
puppies/kittens q7d41
Selamectin (Revolution, 12 mg/kg topically at base Cheyletiellosis
Zoetis) of neck once72
20 mg/kg topically q7d21 PK/flea infestation; further studies are
needed to assess long-term safety in
rabbits at this dose following repeated
application21
Continued
TA BL E 10-3 Antiparasitic Agents Used in Rabbits. (cont’d)

Selamectin (Revolution, 30 mg (8-14 mg/kg) topically Sarcoptic mange
Zoetis) (cont’d) q30 days 2 doses37,76
30 mg (6-18 mg/kg) topically Psoroptes
once76,96
Sulfadimethoxine 50 mg/kg PO once, then Coccidiosis
25 mg/kg q24h 10-
20 days41
Sulfadimethoxine/ 62.5-250 ppm in feed41 Coccidiosis
ormetoprim (Rofenaid 40,
Roche)
Sulfadimidene 100-233 mg/L drinking Coccidiosis
water41
Sulfamerazine 100 mg/kg PO41 Coccidiosis
0.05%-0.15% in drinking
water41
Sulfamethazine 100 mg/kg PO q24h41 Coccidiosis
0.77 g/L drinking water41
0.5%-1% in feed41
Sulfamethoxine 50 mg/kg PO once, Coccidiosis
then 25 mg/kg PO
q24h 10-20 days41
Sulfaquinoxaline 0.02%-0.05% in drinking Coccidiosis; prevention
water41
0.025%-0.1% in drinking Alternating 2 wk periods for 4-8 wk
water112 during weaning
0.1%-0.15% in drinking Coccidiosis; treatment
water41
1 mg/mL in drinking water41
0.025%-0.03% in feed 4-6 During weaning
wk112
125-250 ppm in feed41
Thiabendazole 25-50 mg/kg PO41
50-100 mg/kg PO
q24h 5 days112
0.1% in feed 3 mo41
Toltrazuril 2.5-5 mg/kg PO115 Intestinal coccidiosis
10 mg/kg PO60,71 PK;41 coccidiosis due to Eimeria tenella41
25 ppm in drinking water Coccidiosis
(or 25 mg/kg PO) q24h
2 days, repeat after
5 days41
50 ppm in drinking water17 Hepatic coccidiosis due to Eimeria stiedae
TA BLE 10-4 Chemical Restraint/Sedative/Anesthetic/Analgesic Agents Used

in Rabbits.a,b
Acepromazine — See butorphanol, ketamine, ketamine/
xylazine for combinations
0.25-1 mg/kg IM41 Preanesthetic; sedative; tranquilizer
1-5 mg/kg SC, IM41 Preanesthetic; lower end of dose range
is preferred
Acetaminophen — Short-term use only; use with caution
(Tylenol, McNeil) as associated with liver failure88
200-500 mg/kg PO41 Analgesia
1-2 mg/mL drinking water41
Acetaminophen/ 1 mL elixir/100 mL drinking water41 Analgesia
codeine (120 mg/
12 mg per 5 mL)
Acetylsalicylic acid 5-20 mg/kg PO q24h112 Antiinflammatory; for low grade
(aspirin) analgesia
10-100 mg/kg PO q8-12h41
100 mg/kg PO q8-24h25,41
100 mg/kg PO q48h41
Alfaxalone — Neurosteroid anesthetic; IV dose
(Alfaxan, Jurox) dependent respiratory depression;
no analgesic properties
0.5-1 mg/kg IM85 For additional sedation when
combined with midazolam, an opioid,
and ketamine85
1 mg/kg IV slowly to effect85 Anesthetic induction when used in
conjunction with preanesthetic
sedatives (i.e., midazolam 0.5 mg/kg,
hydromorphone 0.1 mg/kg, ketamine
7 mg/kg, and dexmedetomidine
0.005 mg/kg combined in single
syringe and given IM)85
2-3 mg/kg IV55 Anesthetic induction; give slow
to effect
4 mg/kg IV111 Dilute with 5% dextrose and give over
1 min for smooth induction that allows
intubation
4-6 mg/kg IM62 Deep sedation; longer duration of
action with higher dose
Atipamezole Give same volume SC, IV, IP as Dexmedetomidine and medetomidinec
(Antisedan, Orion) medetomidine or dexmedetomidine (5 reversal41
medetomidine or 10 dexmedetomidine
dose in mg)41
0.25 mg/kg IV112
0.5 mg/kg SC, IM112
1 mg/kg SC, IM, IV41
Atracurium 0.1 mg/kg IV41 Paralysis for intraophthalmic surgery;
requires assisted ventilation
Continued
TA BL E 10-4 Chemical Restraint/Sedative/Anesthetic/Analgesic Agents Used

in Rabbits. (cont’d)
Atropine — Many rabbits possess serum
atropinase, hence very high doses are
often administered; glycopyrrolate
often preferred
0.1-0.5 mg/kg SC, IM41
0.1-3 mg/kg SC41
0.8-1 mg/kg IM41
10 mg/kg SC q20min41,112 To treat organophosphate toxicity
Bupivicaine 0.125%, — Local and regional anesthetic
0.5% techniques; concentrations of 0.125%
or less produce a good sensory block
with least motor effect; epidural
anesthesia; dilute with preservative-
free saline only; total volume should
not exceed 0.33 mL/kg56
1 mg/kg20 Injectable epidural; use 0.125%
preparation56
2 mg/kg84
Buprenorphine — Partial agonist that exerts significant
actions at the mu opioid receptor;
duration of analgesia may be dose
dependent; may cause respiratory
depression;10 see midazolam for
combination
0.01-0.05 mg/kg SC, IM, IV q6-12h25,41 Analgesia
0.012 mg/kg20,56 Epidural anesthesia; dilute with
preservative-free saline only; total
volume should not exceed
0.33 mL/kg56
0.02-0.1 mg/kg SC, IM, IV41,83 Preanesthetic
0.06 mg/kg IV q8h125 Analgesia
Buprenorphine SR- 0.12 mg/kg SC32 Compounded formulation of
LAB (1 mg/mL, sustained-release buprenorphine
ZooPharm)
Butorphanol — See ketamine/xylazine and midazolam
for combinations; mixed agonist/
antagonist with low intrinsic activity at
the mu receptor and strong agonist
activity at kappa and sigma receptors;
duration of analgesia may be dose
dependent; use lower doses IV
0.1-0.5 mg/kg SC, IM, IV q4h25,41 Analgesia
0.3-0.5 mg/kg SC, IM, IV q2-4h123
0.1-1 mg/kg SC, IM, IV q4-6h41
Butorphanol (A) 0.5 mg/kg + (B) 0.5 mg/kg SC, IM43
(B)/acepromazine (A)

Carprofen — Nonsteroidal antiinflammatory; chronic
osteoarthritis or degenerative joint
disease
1-2.2 mg/kg PO q12h25
1-5 mg/kg PO q12-24h41
2-4 mg/kg PO q12-24h10
2-4 mg/kg SC q24h25,41
4 mg/kg SC, IM q24h10,41
Dexmedetomidine — See ketamine/fentanyl and
(Dexdomitor, Orion) midazolam/hydromorphone/ketamine
for combinations; α2 agonist similar to
medetomidine; reverse with
atipamezole
0.005 mg/kg IM79 Preanesthetic when combined with
ketamine
0.035-0.05 mg/kg IM79 Induction/maintenance when
combined with ketamine
Diazepam — Benzodiazepine sedative; IV route
preferred; see ketamine for
combination
0.5-2 mg/kg IM, IV41,67,112 For sedation
1 mg/kg intracavernous33 Seizures; alternative to IV route
1-3 mg/kg IM41 Preanesthetic; tranquilizer
1-5 mg/kg IM, IV25,41 Preanesthetic; tranquilizer
79,80,83
Etomidate 1-2 mg/kg Give slow to effect for anesthetic
induction; short-acting induction
agent; good choice with cardiac
patients
Fentanyl — Mu opioid agonist; analgesia; see
ketamine/dexmedetomidine and
medetomidine/midazolam for
combinations
0.0074 mg/kg IV25,41
Fentanyl patch ½ patch/medium-sized rabbit Postoperative analgesia; do not cut
(3 kg) 3 days41 patch; cover portion not in use
25 μg/h patch/3 kg rabbit 3 days45 Note: rapid hair regrowth decreases
plasma concentrations
12.5 μg/h patch/3/ kg rabbit 3 days25 Do not cut patches; may cause
drowsiness when initially applied
Fentanyl/fluanisone 0.2-0.3 mL/kg41 Premedication; analgesia; sedation
(Hypnorm, Janssen) 0.25 mL/kg SC41
Flumazenil 0.01-0.1 mg/kg IM, IV41 Reversal for benzodiazepines
Flunixin meglumine — Analgesia; nonsteroidal
antiinflammatory41
0.3-2 mg/kg PO, IM, IV q12-24h41 Use for no more than 3 days
Continued

Flunixin meglumine 1.1 mg/kg SC, IM q12h41
(cont’d) 1-2 mg/kg SC q12-24h41
Gabapentin — Neuropathic pain analgesic; indicated
for adjunctive treatment of chronic or
neurogenic pain in dogs and cats at
3 mg/kg PO q24h and for ancillary
therapy of refractory seizures in dogs
at 10-30 mg/kg PO q8h112
3-5 mg/kg PO q12-24h41
25 mg/kg SC75 Dose used to approximate plasma
concentrations in humans
Glycopyrrolate — Anticholinergic; premedication to
prevent salivation and bradycardia
0.01-0.02 mg/kg SC41
0.01-0.1 mg/kg SC, IM41
0.02 mg/kg IV, IO, intratracheally57
Hydromorphone — Opioid analgesic; mainly a mu agonist
with less affinity for delta receptors
0.05-0.2 mg/kg SC, IM q6-8h20
0.1-0.2 mg/kg SC, IM, IV q6-8h66
Ibuprofen — Analgesia; nonsteroidal
antiinflammatory; may have
gastrointestinal side effects
2-7.5 mg/kg PO q4h41
7.5 mg/kg PO q6-8 h41
Isoflurane 3%-5% induction, 1.5%-1.75% MAC ¼ 2.05%;41 prior use of a
maintenance41 sedative or injectable induction agent
(s) is recommended, as use of
preanesthetic agent or combinations
will lower the MAC of inhalants
3%-5% induction, 2%-3%
maintenance41
Ketamine — NMDA receptor antagonist; should be
administered in combination with
other agents; combinations to follow
1-10 mg/kg IM80
5-50 mg/kg SC, IM41
7-10 mg/kg IM79,81 Preanesthetic; add to midazolam/
opioid combination if additional
sedation required81
15 mg/kg IV41
15-20 mg/kg IV41
20-50 mg/kg IM41 60 min of sedation
20 mg/kg IM79 Anesthetic induction, maintenance

Ketamine (K) 25-40 mg/kg + (A) 0.25-1 mg/kg Anesthesia
(K)/acepromazine (A) IM, IV41
(K) 40 mg/kg + (A) 0.5-1 mg/kg IM41 Anesthesia
Ketamine (D) 0.02 mg/kg + (K) 5 mg/kg + (F) May result in mild respiratory
(K)/dexmedetomidine 0.01 mg/kg IM119 depression, respiratory acidosis and
(D)/fentanyl (F) hypoxemia; supplemental oxygen
recommended
Ketamine (K) 10 mg/kg + (D) 0.5 mg/kg IV41 Anesthesia; follow with isoflurane
(K)/diazepam (D) (K) 15 mg/kg + (D) 0.3 mg/kg IM41 Anesthesia; follow with isoflurane
(K) 20-40 mg/kg + (D) 1-5 mg/kg IM41 Anesthesia; follow with inhalant
as needed
(K) 30-40 mg/kg + (D) 2-5 mg/kg IM41 Surgical anesthesia; lower end of dose
range for (D) is preferred; less
preferable than aforementioned (K)/(D)
combinations
Ketamine (K) 5 mg/kg + (Me) 0.35 mg/kg IM, IV41 Surgical anesthesia
(K)/medetomidine (K) 15 mg/kg + (Me) 0.25 mg/kg Anesthetic induction; laryngospasm
(Me)c SC,41 IM54 common
Ketamine (K) 15 mg/kg IM + (Mi) 3 mg/kg IM54 Anesthetic induction
(K)/midazolam (Mi) (K) 25 mg/kg + (Mi) 2-5 mg/kg IM41 May be preferable to use (Mi)
at <2 mg/kg
Ketamine — Anesthesia; may result in bradycardia;
(K)/xylazine (X) less preferable than (K)/(D) with
isoflurane combinations; seldom
indicated
(K) 10 mg/kg + (X) 3 mg/kg IV41
(K) 30-40 mg/kg + (X) 3-5 mg/kg IM41
Ketamine (K)/xylazine (K) 35 mg/kg + (X) 5 mg/kg + (A) Anesthesia; may result in bradycardia;
(X)/acepromazine (A) 0.75 mg/kg IM41 less preferable than (K)/(D) with
indicated
Ketamine (K)/xylazine (K) 35 mg/kg + (X) 5 mg/kg + (B) Anesthesia; may result in bradycardia;
(X)/butorphanol (B) 0.1 mg/kg IM41 less preferable than (K)/(D) with
indicated
Ketamine (K) 7 mg/kg + (Mi) 0.5 mg/kg + (H) Preanesthetic
(K)/midazolam 0.1 mg/kg +
(Mi)/hydromorphone (D) 0.005 mg/kg IM85
(H)/dexmedetomidine
(D)
Ketoprofen — Nonsteroidal antiinflammatory
1 mg/kg IM q12-24h41 Musculoskeletal pain; nonsteroidal
antiinflammatory
1-3 mg/kg IM q12-24h41
3 mg/kg SC, IM q24h25,41 Estimated duration of action
12-24 hr44
Continued

Ketoprofen 2.5% Apply topically (visceral) q6-12 h7 Musculoskeletal pain
topical gel
(Menarini, France)
Lidocaine (2% — Amide local anesthetic; local, regional,
injectable) topical, and epidural anesthesia; also
see Table 5
1 mg/kg78
2-3 mg/kg83
1.5% 0.4 mL/kg epidural41 Epidural anesthesia
10% Topical to glottis41 Facilitates intubation
Lidocaine 2.5%/ Topical to skin Facilitates IV catheter placement
prilocaine 2.5%
(Emla cream)
Maropitant citrate 2 mg/kg SC q24h 3-5 days24 Neurokinin (NK1) receptor antagonist;
(Cerenia, Zoetis) gastrointestinal (visceral) and arthritic
pain; can be administered long term
q48h or
3 weekly as needed24
Medetomidine — Medetomidine is no longer
commercially available in the United
States, although it may be obtained
from select compounding services
0.1-0.25 mg/kg IM41
Medetomidine (Me) 0.2 mg/kg + (F) 0.02 mg/kg + (Mi) Anesthesia; endotracheal intubation
(Me)c/fentanyl 1 mg/kg IM41 and supplemental oxygen are required
(F)/midazolam (Mi)
Medetomidine (Me) 0.35 mg/kg IM + (P) 3 mg/kg IV41 Surgical anesthesia; note high
(Me)c/propofol (P) medetomidine dose41
Meloxicam — Nonsteroidal antiinflammatory;
analgesia; antipyretic; used for
osteoarthritis and postoperative pain;
palatable PO form
0.2 mg/kg SC, IM q24h41
0.2-0.5 mg/kg PO, SC, IM q24h25
0.3 mg/kg PO q24h 10 days23 PK; a higher dose (0.5 mg/kg)20 may
be required, but efficacy and safety
studies have not been performed22
0.3 mg/kg PO q24h41
0.3-1.5 mg/kg PO q24h 5 days133 PK; the higher dose was based on a
limited sample size, but efficacy and
safety studies have not been
performed
1 mg/kg PO q24h46 PK; dose required to achieve plasma
levels associated with analgesia in
other species; clinical efficacy was not
evaluated

Meloxicam (cont’d) 1 mg/kg PO q24h 29 days30 PK; safety studies indicated may be
safe for long-term use in rabbits
Midazolam — Benzodiazepine sedative; may reverse
with flumazenil; more potent, shorter
action than diazepam; water soluble;
rapidly absorbed and less painful than
diazepam when given IM;
combinations to follow
0.25-0.5 mg/kg IM57 When combined with an opioid
0.5-2 mg/kg IM, IV, IP25,41,57 Preanesthetic; tranquilizer
1-2 mg/kg IM, IV, IP41 Preanesthetic; tranquilizer
Midazolam (Mi) 0.5 mg/kg + (Bpr) 0.01-0.05 Add ketamine (1-10 mg/kg) for
(Mi)/buprenorphine mg/kg SC, IM57 additional sedation
(Bpr)
Midazolam (Mi) 0.5 mg/kg + (B) 0.2-0.4 Add ketamine (1-10 mg/kg) for
(Mi)/butorphanol (B) mg/kg SC, IM57 additional sedation and analgesia
(Mi) 0.5-1 mg/kg + (B) 0.25-0.5 Add ketamine 5-10 mg/kg IM for
mg/kg IM90 additional sedation and analgesia
Midazolam (Mi) 0.5 mg/kg + (O) 0.05-0.2 Add ketamine (1-10 mg/kg) for
(Mi)/oxymorphone (O) mg/kg SC, IM57 additional sedation
Morphine — Analgesic; mu receptor agonist;
decreases GI transit time29
0.1 mg/kg20,56 Epidural anesthesia; dilute with
preservative-free saline only; total
volume should not exceed
0.33 mL/kg56
0.5-2.0 mg/kg SC, IM q2-4h20 Analgesia
2-5 mg/kg SC, IM q2-4h25,41
10 mg/kg IM29 Decreased GI transit time and affected
stomach and cecum motility29
Naloxone 0.01-0.1 mg/kg IM, IV25,41 Narcotic reversal; note that analgesic
effects are also reversed; avoid use
following painful procedure as sudden
awareness of pain may predispose to
breath-holding, increased
catecholamine release, and fatal
arrhythmias;41 mu opioid agonist
Oxymorphone 0.05-0.2 mg/kg SC, IM q8-12h41 Analgesia
0.1-0.3 mg/kg SC, IM, IV q3-4h10,112
Pentazocine (Talwin- 5-10 mg/kg IM, IV q2-4h41 Analgesia
V, Upjohn)
Pentobarbital 20-45 mg/kg IV, IP41 Marginal analgesia; autonomic
depression; not recommended
Continued

Piroxicam 0.2 mg/kg PO q8h41 Analgesia; nonsteroidal
antiinflammatory
Propofol — Intravenous nonbarbituate anesthetic;
slow IV; lower dose after pre-med,
higher dose when used alone; see
medetomidine for combination
2-3 mg/kg IV41 Induction after premedication;
maintain with approximately 1 mg/kg
IV q15min
3-6 mg/kg IV41
5-14 mg/kg slow IV To effect
(20 mg/kg/min)41,112
6-8 mg/kg IV induction, followed by Anesthetic induction and maintenance;
0.8-1 mg/kg/min CRI118 premedicated with dexmedetomidine
(20 μg/kg IM), ketamine (5 mg/kg IM),
fentanyl (10 μg/kg IM)118
7.5-15 mg/kg IV26
12.5 mg/kg IV, IO followed by Anesthetic induction and maintenance
1 mg/kg/min CRI93
16 5 mg/kg IV6 Anesthetic induction
Sevoflurane To effect6 Anesthesia; MAC ¼ 3.7%41
6%-8% induction, 1%-3% maintenance Prior use of a sedative or injectable
induction agent is recommended, as
use of preanesthetic combinations will
lower the MAC of inhalants
Thiamylal 15-25 mg/kg IV to effect41
Thiopental 15-30 mg/kg IV to effect41
Tiletamine/zolazepam 3 mg/kg IM41 Sedation prior to gas anesthetic;
(Telazol, Zoetis, tiletamine causes severe renal tubular
Fort Dodge) necrosis at 32 mg/kg and mild
nephrosis at 7.5 mg/kg;41 not
generally recommended for use in
rabbits
Tramadol — Pharmacokinetic data reported to be
variable, data on clinical efficacy
lacking10
4.4 mg/kg IV34 Did not result in isoflurane-sparing
effects34
5 mg/kg SC, IV q8h25
5-15 mg/kg PO q8-12h25
10 mg/kg PO q12-24h10 Recommendation based on personal
experience and anecdotal reports
11 mg/kg PO127 PK; did not achieve adequate plasma
concentrations for analgesia based on
human levels

Xylazine — See ketamine for combinations
1-5 mg/kg SC, IM41 Preanesthetic; tranquilizer; lower end
of dose range preferred; seldom
indicated
Yohimbine 0.2-1 mg/kg IM, IV41 Alpha2-adrenergic antagonist; xylazine
reversal
a
See Table 10-5 for Constant Rate Infusion (CRI) protocols.
b
Drugs and doses chosen dependent on individual patient requirements and health status, procedure planned, and level of
sedation desired. Combination of drugs mixed in one syringe unless otherwise indicated. Atipamezole may be used to
reverse dexmedetomidine or medetomidine, flumazenil may be used to reverse midazolam, and naloxone may be used to
reverse opioids.
c
Medetomidine is no longer commercially available in the United States although it may be obtained from select
compounding services.
TA BLE 10-5 Constant Rate Infusion (CRI) Protocols Used in Rabbits.a

Agent(s) Loading Dose IV CRI Rate IV Per Hour Unless Noted
Butorphanol 0.2-0.4 mg/kg56 0.1-0.2 mg/kg112
0.2-0.4 mg/kg56
Fentanyl 5-10 μg/kg56 10-30 μg/kg56
30-100 μg/kg/min41
56
Ketamine 2-5 mg/kg 0.3-1.2 mg/kg56
Ketamine (K)/ (K) 0.4-0.5 mg/kg + (B) (K) 0.6 mg/kg (0.4-1) + (B) 0.1-0.2 mg/kg81
butorphanol (B) 0.02-0.06 mg/kg81
Ketamine (K)/ (K) 0.4-0.5 mg/kg + (B) (K) 0.4-1 mg/kg + (B) 0.1-0.2 mg/kg82
butorphanol (B) 0.02-0.06 mg/kg82
Ketamine (K)/ (K) 0.4-0.5 mg/kg + (F) (K) 0.6 mg/kg (0.4-1) + (F) 0.005-0.02 mg/kg81
fentanyl (F) 0.005 mg/kg81
Ketamine (K)/ (K) 0.4-0.5 mg/kg + (H) (K) 0.6 mg/kg (0.4-1) + (H) 0.025-0.05 mg/kg81
hydromorphone (H) 0.05 mg/kg81
Ketamine (K)/ (K) 0.4-0.5 mg/kg + (H) (K) 0.4-1 mg/kg + (H) 0.025-0.05 mg/kg82
hydromorphone (H) 0.05 mg/kg82
Lidocaine 2 mg/kg124 50 or 100 μg/kg/min;124 both CRI doses decreased
the isoflurane MAC124
a
Surgical fluid rate is 10 mL/kg/h IV.81
TA BLE 10-6 Ophthalmologic Agents Used in Rabbits.

Amphotericin B (A) 10 μg in 0.05 mL + (Mo) (Mo) strongly augments efficacy of (A)
(liposomal form) 100 μg in 0.05 mL
(A)/moxifloxacin (Mo) intravitreally31
Atropine 1% Topical to eyes q12h prn41 Mydriasis; systemic effects are possible; may be
ineffective in rabbits with pigmented irides or
those that produce atropinase141
Continued
TA BL E 10-6 Ophthalmologic Agents Used in Rabbits. (cont’d)

41
Atropine Topical to eyes Mydriasis for non-albino eyes
1%/phenylephrine 10%
Azithromycin 1% Topical to eyes Bacterial conjunctivitis
(Azasite, Akorn) q12h 2 days, then
q24h 5 days5
Besifloxacin 0.6% Topical to eyes q12h113 Fluoroquinolone; bacterial conjunctivitis/
(Besivance, Bausch & endophthalmitis;102 minimal systemic absorption
Lomb)
Betaxolol 0.5% Topical to eyes q12h70 Glaucoma; effectively decreases intraocular
(Betoptic, Alcon) pressure in rabbits
Ciprofloxacin 0.3% Topical to eyes q8-12h41 Susceptible infections
(Ciloxan, Alcon) 2 drops topical q1h for Ocular penetration injuries; good penetration into
7-14 hr 41 aqueous and vitreous humor
Cyclosporine A 0.05% Topical to eyes q12h131 Dry eye due to autoimmune dacryoadenitis
(Restasis, Allergan)
Cyclosprine A 0.2% Topical to eyes q12h132 Shown to increase tear production in rabbits;
(Optimmune, may inhibit recurrence of precorneal
Schering-Plough) membranous occlusion postoperatively49
Dichlorophenamide 1-2 mg/kg PO q24h41 Glaucoma
(Daranide, Merck)
Diclofenac sodium Topical to eyes137 Nonsteroidal antiinflammatory
0.1% Topical to eyes q12h89 Blepharitis141
41,89
Dorzolamide 2% Topical to eyes q8-12h Glaucoma
(Trusopt, Merck)
Doxycycline 2.5 mg/kg PO q12h89 Encephalitozoon cuniculi-induced glaucoma
monohydrate
Fluconazole 37.5 mg/kg PO q12h8 Aspergillus keratitis
Flurbiprofen sodium Topical to eyes41 Nonsteroidal antiinflammatory; blepharitis141
0.03%
Fusidic acid Topical to eyes q12-24h41 Bacterial conjunctivitis
(Fucithalmic, Leo)
Gatifloxacin 0.3% Topical to eyes q8h113 Bacterial conjunctivitis
(Zymar, Allergan)
Gentamicin Topical to eyes q8h41 Bacterial conjunctivitis
(Tiacil, Virbac)
Ketorolac tromethamine Topical to eyes137 Nonsteroidal antiinflammatory; blepharitis141
0.1%
Marbofloxacin 4 mg/kg IV116 Penetration of marbofloxacin into the aqueous
(Marbocyl FD, and vitreous humor after IV administration was
Vetoquinol) significantly enhanced by intraocular
inflammation
Methylsulfonylmethane Topical to eyes q12h89 Encephalitozoon cuniculi-induced glaucoma
(MSM) ophthalmic 15%
(Alcon)
Metipranolol 0.1%/ Topical to eyes Glaucoma
pilocarpine 2% q8-12h41
TA BLE 10-6 Ophthalmologic Agents Used in Rabbits. (cont’d)

95,102
Moxifloxacin 0.5% Topical to eyes q6h Bacterial conjunctivitis; good aqueous
(Vigamox, Alcon) concentration with both oral and ophthalmic
administration; oral better for vitreous
concentration47
Micafungin 0.1% 0.5 mL subconjunctivally Candida keratitis
q24h 3 wk59
Neomycin/bacitracin/ Topical to eyes q6h41 Susceptible infections; corneal ulceration
polymyxin B
Penicillin G 40,000 U/kg SC q7d 3 Treponema cuniculi-induced blepharitis
treatments49
Phenylephrine 10% — See atropine for combination
Topical to eyes41 Mydriasis
Prednisolone Topical to eyes q6-12h41 Inflammation of eyes; rabbits are a
acetate 1% corticosteroid-sensitive species; use with
extreme caution
Topical to eyes q12h89 Encephalitozoon cuniculi-induced glaucoma
Terbinafine 1% Topical q6h 8 wk13,112 Keratomycosis; compounded
ointment
Timolol 0.5% (Timoptic, Topical to eyes q12h70 Glaucoma
Merck)
Tobramycin 0.3% Topical to eyes q6h13 Bacterial ulcerative keratitis
Tropicamide 1% Topical to eyes41 Mydriasis
Trovafloxacin 0.5% Topical to eyes9 Broad-spectrum; safe for intravitreal injection up
to 25 μg
Vancomycin 0.3%, 1% Topical to eyes q2h for 10 hr Commercially available product not available in
each day 5 days35 the United States;
compounded from injectable form of
vancomycin; used to treat methicillin-resistant
Staphylococcus aureus
Voriconazole Topical to eyes q12h128 Fungal keratitis; compounded to a 1%
voriconazole solution112
TA BLE 10-7 Miscellaneous Agents Used in Rabbits.

Activated charcoal 1 g/kg PO q4-6h63,103 May reduce intestinal absorption
(1 g/5 mL water) of toxins
Aluminum hydroxide 30-60 mg/kg PO q8-12h41 Phosphorus-binder;
hyperphosphatemia due to renal failure
Barium 10-14 mL/kg PO41 Gastrointestinal contrast studies
Benazepril 0.25-0.5 mg/kg PO q24h41 Vasodilator; potentially less nephrotoxic
than enalapril
Blood transfusion (whole 10-20 mL/kg given no faster than Cross-matching advised, especially for
blood) 22 mL/kg/h41 repeated transfusions
Continued
TA BL E 10-7 Miscellaneous Agents Used in Rabbits. (cont’d)

41
Calcium EDTA (edetate 13-27 mg/kg SC, IV Chelation therapy
calcium disodium) (Calcium 27 mg/kg SC q6-12h prn41 Lead toxicosis; diluted to <10 mg/mL
Disodium Versenate, 3 M) with 0.45% NaCl/2.5% dextrose
Cellulose powder (Unifiber, ½-1 tsp/feeding41 Nonsoluble fiber source for rabbits on
Niche) liquid enteral diets; will pass through
small diameter feeding tubes
Chlorpheniramine maleate 0.2-0.4 mg/kg PO q12h41 Antihistamine
Cholestyramine (Questran 2 g/animal PO Ion exchange resin for toxin absorption
Light, Squibb) q24h 18-21 days41 following inappropriate antibiotic
administration; use for treating
enterotoxemia; gavage with 20 mL
water; may result in constipation
Chondroitin sulfate Used empirically at feline dose134 Arthritis; nutraceutical
(Cosequin, Nutramax)
Cimetidine 5-10 mg/kg PO, SC, IM, IV Gastric and duodenal ulcers
q6-12h65,112
Cisapride 0.5 mg/kg PO q8-12h112 Enhances gastrointestinal motility; must
be compounded in United States
Cyclizine 8 mg/rabbit PO q12h41 Vertigo associated with torticollis
Cyproheptadine 1-4 mg/rabbit PO q12-24h51 Possible appetite stimulant
Dexamethasone — Corticosteroids are seldom indicated in
rabbits; rabbits are a corticosteroid-
sensitive species;41 use with extreme
caution and consider concurrent
administration of a gastroprotective
agent
0.2-0.6 mg/kg SC, IM, IV41 Antiinflammatory
0.5-2 mg/kg PO, SC, then taper
dose q12h 3-14 days41
2 mg/kg IM, IV41 Shock; effectiveness is controversial
Digoxin 0.005-0.01 mg/kg PO q12-24h41 Congestive heart failure; atrial fibrillation
Diltiazem 0.5-1 mg/kg PO q12-24h41 Calcium channel blocker for
hypertrophic cardiomyopathy
Diphenhydramine 2 mg/kg PO, SC q8-12h41,112 Torticollis, antihistamine
Doxapram 2-5 mg/kg SC, IV q15min41 Respiratory stimulant
Enalapril 0.1-0.5 mg/kg PO q24-48h65 Beware of hypotensive side effects
Epinephrine 0.2-0.4 mg/kg IM, IV, Cardiac arrest
intratracheally112
Epoetin alpha, recombinant 50-150 U/kg SC q2-3d112 Biosynthetic form of erythropoietin;
(Epogen, Amgen) treatment of anemia; use until PCV is
normal, then q7d for at least 4 wk
Famotidine 0.5-1 mg/kg PO, SC, H2-receptor antagonist used to reduce
IV q12-24h40,112 GI acid production
Fecal transfaunation Mix fresh cecotrophs with warm Dysbiosis; placement of E-collar on
saline, strain through gauze, and donor facilitates collection of sample
administer by gavage41
Ferrous sulfate 4-6 mg/kg PO q24h41 Iron deficiency anemia
TA BLE 10-7 Miscellaneous Agents Used in Rabbits. (cont’d)

Furosemide — Loop diuretic
0.3-2 mg/kg SC, IM, IV41 prn
1-4 mg/kg SC, IM, IV q4-6h112 Pulmonary edema
2-5 mg/kg PO, SC, IM, IV q12h112 Congestive heart failure
prn
Hetastarch (Hespan, 5 mL/kg IV given over 5-10 min; Volume expansion in hypoproteinemic
DuPont) repeat if necessary41 patients; may be of benefit in
endotoxemia
20 mL/kg IV101
Human chorionic 20-25 U/animal IV41 Ovulation
gonadotropin (hCG)
Hydroxyzine 2 mg/kg PO q8-12h41 Antihistamine; antipruritic
Iron dextran 4-6 mg/kg IM once41 Iron deficiency anemia (treatment
or prevention)
Lactated Ringer’s solution 60-90 mL/kg 1 hr41 Treatment for shock
or other appropriate fluid of 100-150 mL/kg/day CRI or Maintenance fluid support
choice divided SC q6-12h41
Lactobacilli — May aid in treatment of enteritis;41
efficacy not determined
Administer PO during antibiotic Give 2 hr before or 2 hr after antibiotic
treatment period, then 5-7 days treatment
beyond cessation41
Levetiracetam 20 mg/kg PO q8h11 Anticonvulsant; dosage not established
(Keppra, UCB) in rabbits, but PD are similar to those in
dogs
Lidocaine 1-2 mg/kg IV (bolus)41 Cardiac arrhythmia
2-4 mg/kg intratracheally41 Cardiac arrhythmia
Loperamide 0.1 mg/kg PO q8h 3 days, then Enteropathies (nonspecific diarrhea);
q24h 2 days112 give in 1 mL water
Maropitant citrate 2 mg/kg SC q24h 3-5 days, May be helpful in arthritis or
(Cerenia, Zoetis) then q48h or 3 weekly if inflammatory conditions; reduces
needed24 visceral pain
Meclizine 2-12 mg/kg PO q24h112 Reduces disorientation and rolling with
41
torticollis (for prevention of motion
12.5-25 mg/kg PO q8-12h sickness in small animals)
Metoclopramide 0.2-0.5 mg/kg PO, SC q6-8 h41 Stimulates gastrointestinal motility
0.2-1 mg/kg PO, IM,
SC q6-24h112
0.5 mg/kg PO, SC q4-12 h41
Mirtazapine 0.3-0.5 mg/kg PO q24h114 Appetite stimulant; dosage not
established in rabbits; cat dose given
here
Nandrolone (Deca- 2 mg/kg SC, IM41 Anabolic steroid; appetite stimulant;
Durabolin, Organon) adjunct to treatment for anemia,
especially in chronic renal failure
Continued
TA BL E 10-7 Miscellaneous Agents Used in Rabbits. (cont’d)

77
Omeprazole 20 mg/kg SC q12h Proton pump inhibitor used as a
gastroprotective agent
Oxytocin 0.1-3 U/kg SC, IM41 Use in delayed, but unobstructed,
parturition; agalactia
Pimobendan 0.1-0.3 mg/kg PO q12-24h41 Phosphodiesterase inhibitor; increases
cardiac contractility with dilated
cardiomyopathy or mitral valve disease
Polysulfated 2.2 mg/kg SC, IM q3d 21-28 Noninfectious, traumatic,
glycosaminoglycan days, then q14d112 or degenerative joint disease
(Adequan, Luitpold)
Potassium citrate 33 mg/kg q8h41 Urinary calculi; may decrease calcium-
based stone formation
Prednisolone — See dexamethasone; rarely indicated
0.25-0.5 mg/kg PO Treatment of nonresponsive torticollis,
q12h 3 days, then when negative for pasteurellosis; give
q24h 3 days, then q48h41 antibiotics concurrently
0.5-2 mg/kg PO q12h112
Prednisone — See dexamethasone; rarely indicated
0.5-2 mg/kg PO41,112 Antiinflammatory
Prochlorperazine 0.2-0.5 mg/kg PO q8h41 Torticollis; doses as high as 30 mg/kg
q8h are used to treat labyrinthine
disorders in humans
Ranitidine 2 mg/kg IV q24h41 Gastric ulceration (often in inappetant
2-5 mg/kg PO q12h112 rabbits)
Sevelamer Dosage not established in animals Human dosage is 2-4 capsules PO
q8h;112 phosphorus binder for
hyperphosphatemia associated with
chronic renal failure; consider
monitoring coagulation parameters, as
vitamin K absorption may be affected;
drug is not absorbed systemically so
toxicity is unlikely
Silymarin (milk thistle) 4-15 mg/kg PO q8-12h65 Nutraceutical used as an adjunctive
20-50 mg/kg PO q24h112 treatment for liver disease;
hepatoprotectant; dosage not
established for rabbits; suggested dose
for small animals
Simethicone 65-130 mg/animal PO q1h 2-3 May reduce abdominal discomfort
treatments41 associated with excess gas
Sodium bicarbonate 2 mEq/kg IV, IP41 Ketoacidosis (pregnancy toxemia);
dose is approximate
Stanozolol 0.5-2 mg PO once112 Stimulates appetite following surgery or
illness; may be available from
compounding pharmacy
Succimer (DMSA) 1050 mg/m2 PO 1 wk, then Lead toxicity
700 mg/m2 2 wk142
Sucralfate 25 mg/kg PO q8-12h41 Gastrointestinal ulcers; may interfere
with other orally administered drugs
TA BLE 10-7 Miscellaneous Agents Used in Rabbits. (cont’d)

1 1
Sulfasalazine ⁄8 - ⁄4 crushed 500 mg May reduce inflammation of intestinal
tablet/animal q8-24 h41 mucosa
Verapamil 2.5-25 μg/kg/h IP129 Postoperative administration decreases
adhesion formation
8-16 mg/kg PO plus 0.5-2 mg/kg Slow-channel calcium blocking agent
SC q24h112
Vitamin A 500-1000 U/kg IM41
Vitamin B complex 0.02-0.4 mL/rabbit SC, IM q24h51 Possible appetite stimulant; vitamin B
deficiency
Vitamin C (ascorbic acid) 100 mg/kg PO q12h112 Nutritional supplement
Vitamin K 1-10 mg/kg IM prn41 Select bleeding disorders and toxicities
TA BLE 10-8 Hematologic and Serum Biochemical Values of Rabbits.41

Measurement Normal Values
Hematology
PCV (%) 30-50
Hgb (g/dL) 8-17.5
RBC (106/μL) 4-8
MCV (fL) 58-75
MCH (pg) 17.5-23.5
MCHC (g/dL) 29-37
Reticulocytes (%) 2-4
Platelets (103/μL) 290-650
WBC (103/μL) 5-12
Heterophils (neutrophils) (%) 35-55
Lymphocytes (%) 25-60
Monocytes (%) 2-10
Eosinophils (%) 0-5
Basophils (%) 2-8
Chemistries
ALP (U/L) 4-70
ALT (U/L) 14-80
Amylase (U/L) 200-500
AST (U/L) 14-113
Bicarbonate (mEq/L) 16.2-31.8
Bile acids (μmol/L) <40
Bilirubin, total (mg/dL) 0-0.75
Continued
TA BL E 10-8 Hematologic and Serum Biochemical Values of Rabbits. (cont’d)

Calcium (mg/dL) 8-14.8
Chloride (mEq/L) 92-112
Cholesterol (mg/dL) 12-116
Creatinine (mg/dL) 0.5-2.6
Glucose (mg/dL) 75-150
LDH (U/L) 34-129
Lipids, total (mg/dL) 280-350
Phosphorus (mg/dL) 2.3-6.9
Potassium (mEq/L) 3.5-7
Protein, total (g/dL) 5.4-7.5
Albumin (g/dL) 2.5-5
Globulin (g/dL) 1.5-3.5
Sodium (mEq/L) 138-155
Triglycerides (mg/dL) 124-156
T3 (ng/dL) 130-430
T4 (μg/dL) 1.7-2.4
Urea nitrogen (mg/dL) 15-50
Vitamin A, plasma (μg/mL) 30-80
Vitamin E, plasma (μg/mL) >1
Vitamin D3 (pmol/L) 20-45 (free-range, outdoors)
TA BL E 10-9 Rabbit Blood Glucose and Sodium Levels as Prognostic

Indicators.65
Blood Glucose Sodium Osmolaritya Tonicitya
Physiologic State (mg/dL) (mEq/L) (mOsm/L) (mOsm/L)
Normal 76-148 136-147 284-312 278-302
Stress (e.g., handling) 144-180 — — —
Severe disease (e.g., 360-540 <129 carries a — —
enterotoxemia, mucoid 2.3 times
enteropathy, GI obstruction) mortality risk
Diabetes mellitus 540-601 — — —
a
Osmolarity and tonicity may be used to differentiate true hyponatremia from pseudohyponatremia (may occur with hyperlipidemia,
severe liver disease, or congestive heart failure).
Calculated tonicity:
Ton (mOsm/L) ¼ 2 Na (mEq/L) + glucose (mg/dL)/18
Calculated osmolarity:
Posm (mOsm/L) ¼ 2 Na (mEq/L) + glucose (mg/dL)/18 + BUN (mg/dL)/2.8
T ABL E 10-10 Biologic and Physiologic Data of Rabbits.41

Parameter Normal Values
Adult body weight, male (buck) 1.5-5 kg
Adult body weight, female (doe) 1.5-6 kg
Birth weight 30-80 g
Respiratory rate 30-60 breaths/min
Tidal volume 4-6 mL/kg
Heart rate 130-325 beats/min
Rectal temperature 38.5-40°C (101.3-104°F)
Life span 5-6 years (up to 15 years)
Food consumption 50 g/kg/day
Water consumption 100 mL/kg/day
Gastrointestinal transit time 4-5 hours
Breeding onset, male 6-10 months
Breeding onset, female 4-9 months
Breeding life of female 4 months to 3.75 years
Reproductive cycle Induced ovulation
Gestation period 29-35 days
Litter size 4-10
Weaning age 4-6 weeks
Dental formula I2/1 C0/0 P3/2 M3/3
T ABL E 10-11 Urinalysis Values in Rabbits.41

Urine volume
Large breeds 20-350 mL/kg/day
Average breeds 130 mL/kg/day
Specific gravity 1.003-1.051
pH 7.7-9.6
Crystals Ammonium magnesium phosphate, calcium carbonate monohydrate,
anhydrous calcium carbonate
Casts, epithelial cells, or bacteria Absent to rare
Leukocytes or erythrocytes Occasional
Albumin Occasional in young rabbits
Protein:creatinine ratio 0.11-0.47
Protein (g/L, reference assay) 0.57-10.66
Protein (Multistix dipsticks) Negative to +++
TAB LE 10-12 Cerebrospinal Fluid Values in Rabbits.41

Leukocyte count 4 cells/μL (1-97 cells/μL in E. cuniculi positive rabbits)
Alkaline phosphatase 5 U/dL
Calcium 5.4 mEq/L
Carbon dioxide 41.2-48.5 mL%
Chloride 127 mEq/L
Cholesterol 33 mg/dL
Creatinine 17 mg/dL
Glucose 75 mg/dL
Lactic acid 1.4-4 mg/dL
Magnesium 2.2 mEq/L
Nitrogen, nonprotein 5.6-16.8 mg/dL
Phosphate 2.3 mEq/L
Potassium 3 mEq/L
Protein, total 13-59 mg/dL (31-154 mg/dL in E. cuniculi positive rabbits)
Sodium 149 mEq/L
Urea nitrogen 20 mg/dL
TAB LE 10-13 Electrocardiographic (ECG) and Echocardiographic Values

in Rabbits.41
ECG Parameter Normal Values
Heart rate 198-330 beats/mina
Measurements (lead II)
P wave
Duration (width) 0.01-0.05 sec
Amplitude (height) 0.04-0.12 mv
P-R interval
Duration 0.04-0.08 sec
QRS complex
R-wave amplitude 0.03-0.039 mv
Q-T interval
T wave
Amplitude 0.05-0.17 mv
Electrical axis (frontal plane) 43 to +80 degrees
Thickness of interventricular septum in diastole 0.143-0.310 cm
Thickness of interventricular septum in systole 0.217-0.403 cm
Left ventricular internal diameter in diastole 1.187-1.906 cm
T ABL E 10-13 Electrocardiographic (ECG) and Echocardiographic Values

ECG Parameter Normal Values
Left ventricular internal diameter in systole 0.783-1.353 cm
Thickness of left ventricular free wall in diastole 0.16-0.28 cm
Thickness of left ventricular free wall in systole 0.243-0.455 cm
Fractional shortening 22.6%-36.83%
Ejection fraction 49.07%-70%
Aortic diameter 0.673-0.980 cm
Left atrial appendage diameter 0.753-1.200 cm
Left atrial appendage diameter:aortic diameter 0.94-1.54
Mitral valve E-point–to–septal separation interval 0.120-0.233 cm
Doppler heart rate 115-234 beats/min
Maximal aortic outflow velocity 0.56-1.06 m/sec
Maximal pulmonary artery outflow velocity 0.34-0.84 m/sec
Maximal mitral E-wave velocity 0.41-0.83 m/sec
Maximal mitral A-wave velocity 0.19-0.44 m/sec
Maximal mitral E-wave velocity:A-wave velocity 1.34-3.55
a
Lower values may be expected in acclimated rabbits.
T ABL E 10-14 Determining the Sex of Mature Rabbits.41

Male Female
• Protrude penis by manipulating skin of • There is a common orifice for both the vagina
prepuce and urethra (like dogs and cats)
• Palpate for testicles • No structure like a “penis” can be protruded
• Anogenital distance is longer from the urogenital orifice
• Anogenital distance is shorter
T ABL E 10-15 Drugs Reported to Be Toxic in Rabbits.a

Drug Comments
Amoxicillin41 Enteritis; enterotoxemia
Amoxicillin/clavulanic acid41 Enteritis; enterotoxemia
Ampicillin41 Enteritis; enterotoxemia, high risk especially if given orally
Benzimidazoles (fenbendazole, Bone marrow suppression reported; recommend intratreatment
oxibendazole, albendazole)52 CBC to r/o anemia, leukopenia, thrombocytopenia
Cephalosporins41 Enteritis; enterotoxemia if given orally
Clindamycin41 Enteritis; enterotoxemia, high risk
Erythromycin41 Enteritis; enterotoxemia
Fipronil41 Can cause neurologic disease and death
Continued
TAB LE 10-15 Drugs Reported to Be Toxic in Rabbits. (cont’d)

Drug Comments
Lincomycin41 Enteritis; enterotoxemia, high risk
Penicillin112 Enteritis; enterotoxemia if given orally
Procaine41 May be fatal at doses of 0.4 mg/kg
Tiletamine41 Nephrotoxic
a
There have also been some reports of antibiotic-related colitis in rabbits given penicillin/streptomycin, trimethoprim/
sulfamethoxazole, tetracycline, and gentamicin.
TAB LE 10-16 Treatments Used in the Management of Rabbit Gastrointestinal

Syndrome (RGIS).a

Buprenorphine 0.01-0.05 mg/kg SC, IV, IP q6-12h41 Analgesia
Butorphanol 0.1-0.5 mg/kg SC, IM, IV q4h41 Analgesia
Cisapride 0.5 mg/kg PO q8-12h112 Enhances gastrointestinal motility;
compounded in United States
Cyproheptadine 1-4 mg/rabbit PO q12-24h51 Possible appetite stimulant
HCl
Enrofloxacin 5 mg/kg PO, SC, IM, IV q12h15,16,41 Suspected primary bacterial
enteritis (rare in rabbits)
Famotidine 0.5-1 mg/kg PO, SC, IV q12-24h40,111 H2-receptor antagonist used to
reduce GI acid production
Fluid therapy Weight (kg) % dehydration 1000 mL ¼ fluid Add deficit to maintenance
deficit divided into SC boluses or divided IV per hr requirement of 3-4 mL/kg/h
over 12-24 hr51
60-90 mL/kg 1 hr Shock therapy
100-150 mL/kg/day constant rate infusion or Maintenance fluid support
divided SC q6-12h
Herbivore Follow manufacturer’s instructions Syringe feeding; use fine grind for
critical care diet nasogastric tubes
Hydromorphone 0.05-0.2 mg/kg SC, IM, IV q6-8h20 Analgesia
Lidocaine 2 mg/kg IV loading dose given over 5 minutes CRI for severe, refractory cases of
followed by 60-100 μg/kg/min124 RGIS
100 μg/kg/min 2 days125 Better surgical and postoperative
outcome than buprenorphine
Maropitant 2 mg/kg SC q24h 3-5 days; then q48h May be helpful in inflammatory
citrate (Cerenia, or 3 weekly if needed24 conditions; reduces visceral pain
Zoetis)
Meloxicam 0.3-1 mg/kg PO q24h23,133 NSAID; use only if well hydrated
with normal renal parameters
Metoclopramide 0.2-0.5 mg/kg PO, SC q6-8h41 Stimulates gastrointestinal motility
0.01-0.09 mg/kg/h IV112 CRI
Metronidazole 20 mg/kg PO q12h for 3-5 days112 For suspected clostridial
overgrowth and enterotoxemia
5 mg/kg slow IV q12h112
T ABL E 10-16 Treatments Used in the Management of Rabbit Gastrointestinal

Syndrome (RGIS). (cont’d)
Midazolam 0.25-0.5 mg/kg IM, IV57 Antianxiety; may also stimulate
appetite
Ranitidine 2 mg/kg IV q24h41 Gastric ulceration (often
2-5 mg/kg PO q12h112 in inappetant rabbits)
Simethicone 65-130 mg/animal PO q1h 2-3 treatments41 May reduce abdominal discomfort
associated with excess gas
Thermal support Provide thermal support if body temperature Avoid overheating
<99°F51
Trimebutine 1.5 mg/kg PO, IV86 Enhance GI motility; not available
in the United States; oral available
in Canada
Vitamin B 0.02-0.4 mL/rabbit SC, IM q24h51 Possible appetite stimulant
Complex
a
Concurrent to treatment, it is important to correct the cause (e.g., boredom, stress, excessive shedding, inadequate dietary
roughage, nutritional deficiency or imbalance, disease, toxin, obesity). Surgical intervention is no longer considered the primary
treatment option and is rarely indicated except in cases of complete obstruction.
T ABL E 10-17 Bronchoalveolar Lavage (BAL) in Rabbits.a,41

BAL Parameter Results and Comments
Volume 40%-76% recovery ¼ 1.2-2.3 mL
Leukocyte count 200-700 cells/μL, predominantly macrophages
Heterophils 0-28 cells/μL (0%-5%)
Lymphocytes 15-98 cells/μL (4%-30%)
Macrophages 180-602 cells/μL (69%-94%)
Eosinophils 0-60 cells/μL (0%-12%)
a
Bronchoscopic bronchoalveolar lavage in New Zealand white rabbits was performed with 3 mL of sterile saline into both left
bronchus and right bronchus.
T ABL E 10-18 Clinical Signs and Behavioral Changes Used in the Assessment
of Pain in Rabbits.a
Clinical Signs Behavioral Changes
Change of body posture; tensing of abdominal muscles, Decreased grooming activity; piloerection;
pressing abdomen onto ground unkempt and ruffled fur coat
Change of body posture; tucking of abdomen, hunched Decreased interest in food or cessation of food
body; abdominal splinting on palpation intake
Eyelids squinted; lack of focus; orbit may be retracted Decreased frequency and duration of exploring/
or bulging searching
Muzzle and nares contracture; increased intensity Decreased frequency and duration of
associated with level of pain movement or response to stimuli
Increased teeth grinding (bruxism) Decreased conspecific interaction
Ears pinned back, held close to head Irritable or aggressive temperament
Continued
TAB LE 10-18 Clinical Signs and Behavioral Changes Used in the Assessment
of Pain in Rabbits. (cont’d)
Clinical Signs Behavioral Changes
Increased heart rate; increased frequency and depth Stiff gait, lameness, staggering; difficulty
of respirations finding comfortable resting position
Decreased body weight over time Decreased fecal output or decreased size of
fecal pellets
a
Modified from Fisher (2010).42
TAB LE 10-19 Percentage of Antibiotic Susceptibility Results for the Most

Common Bacteria Isolated From Nasal Cultures of 121 Rabbits
With Signs of Upper Respiratory Disease.120
Bacteria a
Pateurella Bordetella Pseudomonas Staphylococcus
multocida bronchiseptica spp. (N ¼ 41) spp. (N ¼ 27)
(N ¼ 106) (N ¼ 99)
Antibiotic S I R S I R S I R S I R
Cephalexin 100 0 0 2.0 0 98.0 2.4 2.4 95.2 88.9 0 11.1
Danofloxacin 100 0 0 43.4 40.4 16.2 65.9 22.0 12.1 77.8 18.5 3.7
Doxycycline 97.2 2.8 0 88.9 2.0 9.1 56.1 7.3 36.6 74.1 3.7 22.2
Enrofloxacin 100 0 0 71.7 15.2 13.1 58.5 22.0 19.5 81.5 14.8 3.7
Gentamicin 99.1 0.9 0 96 1.0 3.0 75.6 4.9 19.5 85.2 0 14.8
Marbofloxacin 100 0 0 88.9 6.1 5.0 87.8 4.9 7.3 96.3 0 3.7
Oxytetracycline 97.2 0 2.8 86.9 2.0 11.1 63.4 9.8 26.8 74.1 0 25.9
Trimethoprim- 93.4 5.7 0.9 81.8 1.0 17.2 24.4 19.5 56.1 92.6 3.7 3.7
sulfamethoxazole
a
S, sensitivity; I, intermediate; R, resistant.
TAB LE 10-20 Sensitivity and Specificity Calculators for IgM and IgG Titers and
CRP Levels Relative to the Diagnosis of Suspected
Encephalitozoon cuniculi Infections in Pet Rabbits.a,27
Negative
IgM IgG CRP > Sensitivity Specificity Positive Predictive Predictive
1:64 1:512 38 mg/L (%) (%) Value (%) Value (%)
+ ND ND 69 75 88 48
ND + ND 62 78 88 44
ND ND + 40 89 90 38
+ + ND 58 89 92 41
+ ND + 27 100 100 34
ND + + 22 97 95 32
+ + + 20 100 100 32
a
CRP, C-Reactive Protein; ND, results of analyte not included in analysis.
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Rabbits: Peter Fisher - Jennifer Graham

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Chapter 10 Rabbits

Peter Fisher | Jennifer Graham

TA BLE 10-1 Antimicrobial Agents Used in Rabbits.a

Agent Dosage Comments

TA BL E 10-1 Antimicrobial Agents Used in Rabbits. (cont’d)

Agent Dosage Comments

TA BLE 10-1 Antimicrobial Agents Used in Rabbits. (cont’d)

Agent Dosage Comments

TA BL E 10-1 Antimicrobial Agents Used in Rabbits. (cont’d)

Agent Dosage Comments

TA BL E 10-2 Antifungal Agents Used in Rabbits.a

TA BLE 10-2 Antifungal Agents Used in Rabbits. (cont’d)

Agent Dosage Comments

TA BL E 10-3 Antiparasitic Agents Used in Rabbits.

Agent Dosage Comments

TA BLE 10-3 Antiparasitic Agents Used in Rabbits. (cont’d)

Agent Dosage Comments

TA BL E 10-3 Antiparasitic Agents Used in Rabbits. (cont’d)

Agent Dosage Comments

TA BLE 10-4 Chemical Restraint/Sedative/Anesthetic/Analgesic Agents Used

TA BL E 10-4 Chemical Restraint/Sedative/Anesthetic/Analgesic Agents Used

TA BLE 10-4 Chemical Restraint/Sedative/Anesthetic/Analgesic Agents Used

TA BL E 10-4 Chemical Restraint/Sedative/Anesthetic/Analgesic Agents Used

TA BLE 10-4 Chemical Restraint/Sedative/Anesthetic/Analgesic Agents Used

TA BL E 10-4 Chemical Restraint/Sedative/Anesthetic/Analgesic Agents Used

TA BLE 10-4 Chemical Restraint/Sedative/Anesthetic/Analgesic Agents Used

TA BL E 10-4 Chemical Restraint/Sedative/Anesthetic/Analgesic Agents Used

TA BLE 10-4 Chemical Restraint/Sedative/Anesthetic/Analgesic Agents Used

TA BLE 10-5 Constant Rate Infusion (CRI) Protocols Used in Rabbits.a

TA BLE 10-6 Ophthalmologic Agents Used in Rabbits.

Agent Dosage Comments

TA BL E 10-6 Ophthalmologic Agents Used in Rabbits. (cont’d)

Agent Dosage Comments

TA BLE 10-6 Ophthalmologic Agents Used in Rabbits. (cont’d)

Agent Dosage Comments

TA BLE 10-7 Miscellaneous Agents Used in Rabbits.

Agent Dosage Comments

TA BL E 10-7 Miscellaneous Agents Used in Rabbits. (cont’d)

Agent Dosage Comments

TA BLE 10-7 Miscellaneous Agents Used in Rabbits. (cont’d)

Agent Dosage Comments

TA BL E 10-7 Miscellaneous Agents Used in Rabbits. (cont’d)

Agent Dosage Comments

TA BLE 10-7 Miscellaneous Agents Used in Rabbits. (cont’d)

Agent Dosage Comments

TA BLE 10-8 Hematologic and Serum Biochemical Values of Rabbits.41

TA BL E 10-8 Hematologic and Serum Biochemical Values of Rabbits. (cont’d)

TA BL E 10-9 Rabbit Blood Glucose and Sodium Levels as Prognostic

T ABL E 10-10 Biologic and Physiologic Data of Rabbits.41

T ABL E 10-11 Urinalysis Values in Rabbits.41

TAB LE 10-12 Cerebrospinal Fluid Values in Rabbits.41

TAB LE 10-13 Electrocardiographic (ECG) and Echocardiographic Values

T ABL E 10-13 Electrocardiographic (ECG) and Echocardiographic Values

T ABL E 10-14 Determining the Sex of Mature Rabbits.41

T ABL E 10-15 Drugs Reported to Be Toxic in Rabbits.a

TAB LE 10-15 Drugs Reported to Be Toxic in Rabbits. (cont’d)

TAB LE 10-16 Treatments Used in the Management of Rabbit Gastrointestinal

Agent Dosage Comments

T ABL E 10-16 Treatments Used in the Management of Rabbit Gastrointestinal