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    6-Pharma Table 2015

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    Fariz Aziz
    1. The document discusses various classes of drugs that affect the autonomic nervous system and neuromuscular function including cholinergic agents, adrenergic agonists and antagonists, and neuromuscular blockers. 2. It also discusses the different types of adrenoceptors and their functions. 3. Various classes of drugs used to treat cardiovascular conditions such as hypertension, angina, congestive heart failure, and arrhythmias are listed along with examples of drugs from each class. 4. The mechanism of action of ACE inhibitors in decreasing blood pressure by inhibiting angiotensin-converting enzyme is explained. Common ACE inhibitors and angiotensin receptor

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    6-Pharma Table 2015

    Uploaded by

    Fariz Aziz
    44 views4 pages
    1. The document discusses various classes of drugs that affect the autonomic nervous system and neuromuscular function including cholinergic agents, adrenergic agonists and antagonists, and neuromuscular blockers. 2. It also discusses the different types of adrenoceptors and their functions. 3. Various classes of drugs used to treat cardiovascular conditions such as hypertension, angina, congestive heart failure, and arrhythmias are listed along with examples of drugs from each class. 4. The mechanism of action of ACE inhibitors in decreasing blood pressure by inhibiting angiotensin-converting enzyme is explained. Common ACE inhibitors and angiotensin receptor

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    1. The document discusses various classes of drugs that affect the autonomic nervous system and neuromuscular function including cholinergic agents, adrenergic agonists and antagonists, and neuromuscular blockers. 2. It also discusses the different types of adrenoceptors and their functions. 3. Various classes of drugs used to treat cardiovascular conditions such as hypertension, angina, congestive heart failure, and arrhythmias are listed along with examples of drugs from each class. 4. The mechanism of action of ACE inhibitors in decreasing blood pressure by inhibiting angiotensin-converting enzyme is explained. Common ACE inhibitors and angiotensin receptor

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    44 views4 pages

    6-Pharma Table 2015

    Uploaded by

    Fariz Aziz
    1. The document discusses various classes of drugs that affect the autonomic nervous system and neuromuscular function including cholinergic agents, adrenergic agonists and antagonists, and neuromuscular blockers. 2. It also discusses the different types of adrenoceptors and their functions. 3. Various classes of drugs used to treat cardiovascular conditions such as hypertension, angina, congestive heart failure, and arrhythmias are listed along with examples of drugs from each class. 4. The mechanism of action of ACE inhibitors in decreasing blood pressure by inhibiting angiotensin-converting enzyme is explained. Common ACE inhibitors and angiotensin receptor

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    © All Rights Reserved
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    1

    Drug classes
    Drugs affecting the autonomic Neurons & Neuromuscular function

    Cholinergic Agent Adrenergic Agonist Adrenergic Antagonist Neuromuscular Blockers


    Cholinergic
    Direct indirect Antagonist Direct Acting indirect Acting ALPHA BETA Competitive Depolarizing
    Acting (Anti Nondepolarizing
    esterase)
    Acetyl choline Physostigmine Atropine E&NE (a1B) & Ephedrine Prazocin Propranolol D tubocurarine Succinylcholine
    Ephedrine side effects:
    Hyperthermia
    Apnea
    Pilocarpine Neostigmin Homatropine Isoproterenol (B) Amphetamine Terazosin Metoprolol Gallamine

    Bethanechol pyridostigmin Benzotropine Phenylephrine (a1) Doxazocin Labetalol Pancuronium

    Edrophonium Scopolamine Methoxamine (a1) Phenoxy Metocurine


    Benzamine
    Ipratropium (shake Clonidine (a2) Tyramine phentolamine Overcome by
    before use) Neostigmine
    physostigmine
    Edrophonium
    (choline
    esterase
    inhibitor)
    Terbutaline
    Dobutamine

    Tel:+201222339340
    2

    Adreno- Receptors

    Alpha 1 Alpha 2 Beta 1 Beta 2


    -Vasoconstriction - Inhibition of norepinephrine -Tachycardia -Vasodilation
    Increased peripheral resistance release (presynaptic) - Increased myocardial Slightly decreased peripheral
    Increased blood pressure -Inhibition of insulin release contractility resistance
    -Mydriasis -Increased lipolysis -Broncho dilation
    -Increased closure of internal -increase release of rennin -Increased muscular and liver
    sphincter of the bladder glycogenolysis.
    -Increased release of glucagon.
    -Relaxed uterine smooth muscle

    Tel:+201222339340
    3

    Drugs affecting CVS

    a)Antihypertensive B)antianginal C)CHF D)Antiarrhythmia

    *Diuretics *org NO3- *vasodilators *Na channel blocker

    +thiazides +isosorbide dinitrate +Hydralazine +quinine

    +loop diuretic +nitroglycerin +isosorbide +procainamide

    +K+ sparing diuretics +lidocaine

    *vasodilators (direct) *B blockers *Duiretics *B blocker

    +hydralazine +propranolol *amrinone and +propranolol

    +minoxidil milrinone (inodilator) +metoprolol

    +Na nitropruside inotropic and vasodilator

    +diazoxide inh CAMP phosphodiesteraze enz

    *ca channel blocker *ca channel blocker *inotropic agents *K+ channel blocker

    +verapamil +verapamil +e.g. Digoxin +Amiodarone

    +diltiazim +diltiazim & digitoxin +bretylium

    +nifedipine +nifedipine +dobutamine

    *ACE I *Ca+ channel blocker

    Tel:+201222339340
    4

    Effect of ACE I:
    Angiotensinogen

    (&2 globulin in blood) aliskiren decrease output of sympathetic

    Rennin (-) (from kidney) nervous system

    Angiotensin I ACE decrease angiotensin II increase vasodilation (+) decrease B.P


    Inactive Of vascular smooth muscle

    Decrease retention of Na+ & H2O

    ACE inhibitors increase level of bradykinin

    ACEI : *enalapril

    *lisinopril *fosinopril (used in renal impairment) angiotensin II antagonist (ARBs):


    *quinapril *trindolapril *valsartan *eprosartan

    *captopril *moexipril *losartan *telmisartan

    *benozepril *perindopril * irbesartan *olmesartan

    *ramipril *candesartan

    Tel:+201222339340

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