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    Pharmaceutical Sciences: Teneligliptin Induced Persistent Diarrhea

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    iajps
    This document describes a case report of a 65-year-old man who developed persistent diarrhea after starting treatment with the oral hypoglycemic drug Teneligliptin for type 2 diabetes mellitus. The man experienced profuse, watery diarrhea with 5 bowel movements per day and lost 5 kg in weight over 2 weeks. His symptoms did not improve with antibiotics, probiotics, or antidiarrheal medications. A review found that Teneligliptin was recently added to his diabetes treatment regimen. His diarrhea resolved within 10 days of discontinuing Teneligliptin. The document discusses Teneligliptin as a potential rare cause of diarrhea and the importance of considering medication history when evaluating diarrhea.

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    Pharmaceutical Sciences: Teneligliptin Induced Persistent Diarrhea

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    iajps
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    This document describes a case report of a 65-year-old man who developed persistent diarrhea after starting treatment with the oral hypoglycemic drug Teneligliptin for type 2 diabetes mellitus. The man experienced profuse, watery diarrhea with 5 bowel movements per day and lost 5 kg in weight over 2 weeks. His symptoms did not improve with antibiotics, probiotics, or antidiarrheal medications. A review found that Teneligliptin was recently added to his diabetes treatment regimen. His diarrhea resolved within 10 days of discontinuing Teneligliptin. The document discusses Teneligliptin as a potential rare cause of diarrhea and the importance of considering medication history when evaluating diarrhea.

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    31.IAJPS31102020

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    This document describes a case report of a 65-year-old man who developed persistent diarrhea after starting treatment with the oral hypoglycemic drug Teneligliptin for type 2 diabetes mellitus. The man experienced profuse, watery diarrhea with 5 bowel movements per day and lost 5 kg in weight over 2 weeks. His symptoms did not improve with antibiotics, probiotics, or antidiarrheal medications. A review found that Teneligliptin was recently added to his diabetes treatment regimen. His diarrhea resolved within 10 days of discontinuing Teneligliptin. The document discusses Teneligliptin as a potential rare cause of diarrhea and the importance of considering medication history when evaluating diarrhea.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    40 views3 pages

    Pharmaceutical Sciences: Teneligliptin Induced Persistent Diarrhea

    Uploaded by

    iajps
    This document describes a case report of a 65-year-old man who developed persistent diarrhea after starting treatment with the oral hypoglycemic drug Teneligliptin for type 2 diabetes mellitus. The man experienced profuse, watery diarrhea with 5 bowel movements per day and lost 5 kg in weight over 2 weeks. His symptoms did not improve with antibiotics, probiotics, or antidiarrheal medications. A review found that Teneligliptin was recently added to his diabetes treatment regimen. His diarrhea resolved within 10 days of discontinuing Teneligliptin. The document discusses Teneligliptin as a potential rare cause of diarrhea and the importance of considering medication history when evaluating diarrhea.

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    IAJPS 2020, 07 (10), 147- 149 Sheba Susan Chacko et al ISSN 2349-7750

    CODEN [USA]: IAJPBB ISSN : 2349-7750

    INDO AMERICAN JOURNAL OF


    PHARMACEUTICAL SCIENCES
    SJIF Impact Factor: 7.187
    http://doi.org/10.5281/zenodo.4072510

    Available online at: http://www.iajps.com A Case Report

    TENELIGLIPTIN INDUCED PERSISTENT DIARRHEA


    Sheba Susan Chacko*1, Josna James1, Nigel V Sailesh2, Jency Maria Koshy3
    1
    Clinical Pharmacist, Department of General Medicine, Believers church Medical College
    Hospital, Thiruvalla, Kerala
    2
    Junior Resident, Department of General Medicine, Believers church Medical College Hospital,
    Thiruvalla, Kerala
    3
    Professor and Unit Head of General Medicine, Believers church Medical College Hospital,
    Thiruvalla, Kerala
    Article Received: September 2020 Accepted: September 2020 Published: October 2020
    Abstract:
    Teneligliptin is an Oral hypoglycemic agent (OHA) widely used for the treatment of Type 2 Diabetes Mellitus in
    adults. Rare side effects such as hypoglycemia, diarrhea, loss of appetite and abdominal distress have been noted
    with the usage of Teneligliptin.
    Here we report the case of a 65-year-old man diagnosed with Type 2 Diabetes Mellitus who developed profuse
    diarrhea and significant weight loss following intake of Teneligliptin.
    Key Words: Teneligliptin, Type2 Diabetes Mellitus, Diarrhea
    Corresponding author:
    Sheba Susan Chacko, QR code
    Clinical Pharmacist-Department of General Medicine
    Believers Church Medical College Hospital, Thiruvalla, Kerala
    Email Id: shebasusanchacko@gmail.com

    Please cite this article in press Sheba Susan Chacko et al, Teneligliptin Induced Diarrhea., Indo Am. J. P. Sci, 2020; 07(10).

    www.iajps.com Page 147


    IAJPS 2020, 07 (10), 147- 149 Sheba Susan Chacko et al ISSN 2349-7750

    INTRODUCTION: mellitus. DPP4 results in increased activity of


    Teneligliptin is an oral dipeptidyl peptidase 4(DPP4) glucagon like peptide-1(GLP-1) and glucose
    inhibitor indicated for the management of Type 2 dependent insulinotropic peptide (GIP),the incretin
    Diabetes mellitus in adults. The rare side effects of hormones.Through the action of GLP-1 & GIP,DPP4
    Teneligliptin are hypoglycemia, abdominal distress, inhibitors improve preprandial and postprandial
    loss of appetite, constipation, diarrhea, functional glucose by enhancing insulin secretion and reducing
    gastric bloating and headache (1). Here we present a postprandial concentrations of glucagon (2). DPP4
    case of Teneligliptin induced diarrhea and significant inhibitors are associated with enhanced beta cell
    weight loss. functions, low risk of hypoglycemia, weight gain, and
    good tolerability profile (3).
    CASE REPORT:
    A 65-year-old Doctor presented to the medicine OPD Teneligliptin is administered as 20mg tablets once
    of a tertiary care centre with episodes of loose stools daily prior to meals. It can be used without dose
    since 2 weeks. Stools were watery in consistency, adjustment even in patients with renal impairment,
    voluminous and had 5 episodes per day. He had no including those on dialysis. It has a unique
    history of fever, abdominal pain, blood or mucus in pharmacokinetic profile involving elimination by
    stool or any history of food intake from outside. He multiple pathways, including hepatic metabolism by
    lost 5kg over a period of 2 weeks. He had already cytochrome P450 3A4 and flavin containing
    received oral antibiotics (Ciprofloxacin+Tinidazole), monooxygenase 3 and hence it is excreted by kidney
    Probiotics and Racecadrotil, prior to this consultation in an unchanged form (4).
    however with no relief of symptoms. He was a known
    case of Type 2 Diabetes mellitus since 19 years and The side effects of teneligliptin given in various
    was on oral hypoglycemic agents(OHA)and Insulin literatures are hypoglycemia, loss of appetite,
    with reasonable glycemic control. constipation, diarrhea, functional gastric bloating,
    headache and abdominal distress. In a clinical study
    His general physical examination and systemic conducted in India, it was found that approximately
    examination were unremarkable. He was given a 2.5% of patient receiving Teneligliptin treatment
    course of Rifaxamin for 5 days and was advised to develop loose stools (5). Mechanism of Teneligliptin
    continue Racecadrotil for 5 more days. His stool induced Diarrhea remain unclear.
    analyses, culture and hematological parameters were
    normal. Considering his age the treating physician Drug history is a vital part in the evaluation of patients
    made a plan to do a colonoscopy, if his symptoms were with diarrhea. The most frequently involved drugs
    to persist. causing diarrhea are antimicrobials, laxatives, OHAs,
    magnesium containing antacids, lactose or sorbitol
    He reported back to the outpatient department with no containing products. Non-steroidal anti-inflammatory
    relief of symptoms. On reviewing the treatment drugs, prostaglandins, antineoplastic, antiarrhythmic
    history, it was noted that he was on Tab. Metformin and cholinergic agents also are known to cause
    with Glimepiride twice daily, Tab.Linagliptin once diarrhea. Hence drug history is a crucial while
    daily and Inj.Glargine once daily. However, one evaluating patient with diarrhea.
    month prior to developing diarrhea, on doctor’s advice
    he had switched over to Teneligliptin from Linagliptin. CONCLUSION:
    Considering a remote possibility of drug induced Clinicians should be aware of Teneligliptin as an
    diarrhea, it was decided to stop teneligliptin and to inciting cause for loose stools. While evaluating the
    observe. cause for loose stools, drug history of patient is vital
    which would avert physician from doing various
    His loose stools gradually decreased and subsided with invasive and expensive investigations.
    in a duration of 10 days. On following up for the next
    3 months, he continued to remain asymptomatic. REFERENCES:
    Currently he is on Metformin twice daily, Glimepiride 1. Priyambada D.Teneligliptin/Uses,Side Effects
    twice daily and Inj. Glargine once daily with good and Dosage.Docprime.com.2018.Available
    glycemic control. from: https://docprime.com/teneligliptin-mddp

    DISCUSSION: 2. Moore KB,Saudek CD.Therapeutic potential of


    Teneligliptin belongs to the third generation DPP4 dipeptidyl peptidase –IV inhibitors in patients
    inhibitor used for treatment of Type 2 Diabetes

    www.iajps.com Page 148


    IAJPS 2020, 07 (10), 147- 149 Sheba Susan Chacko et al ISSN 2349-7750

    with diabetes mellitus.American journal of implications for clinical practice.Drugs.


    therapeutics.2008 Sep 1;15(5):484-91 2019;979(7):733-50.
    https://doi.org/10.1007/s40265-019-01086-0
    3. Cade WT.Diabetes-related microvascular and
    macrovascular disease in the physical therapy 5. Panacea Biotec Limited. Product
    setting.Physical therapy.2008 Nov1;88(11)1322- Monograph:.Tenepan- M 500;2019.Available
    35 from:
    https://media.panaceabiotec.com/documents/201
    4. Ceriello A,De Nigris V,lijima H,Matsui T,Gouda 9/7/27/ProductMonograph-TENEPAN-M-
    M.The unique pharmacological and 2016May05.pdf
    pharmacokinetic profile of teneligliptin

    www.iajps.com Page 149

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