Location via proxy:   [ UP ]  
[Report a bug]   [Manage cookies]                
Scribd Logo
Upload

Welcome to Scribd!

  • 38 views

    HACVD Patho

    Uploaded by

    Angel Filoteo
    The document summarizes the pathophysiology of heart and cardiovascular disease. It describes how LDL and triglycerides damage endothelial cells, leading platelets and monocytes to adhere and abnormal proliferation of smooth muscles. This causes inflammation and narrowing of blood vessels from atherosclerotic plaque formation. Over time, plaque rupture can decrease blood flow and increase vascular resistance, raising afterload and preload on the heart. As a compensatory mechanism, the heart undergoes hypertrophy but eventually fails in oxygen compensation, leading to tissue ischemia, injury, and infarction which decreases cardiac output and causes systemic hypoxia and multiorgan failure and death.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd

    HACVD Patho

    Uploaded by

    Angel Filoteo
    38 views1 page
    The document summarizes the pathophysiology of heart and cardiovascular disease. It describes how LDL and triglycerides damage endothelial cells, leading platelets and monocytes to adhere and abnormal proliferation of smooth muscles. This causes inflammation and narrowing of blood vessels from atherosclerotic plaque formation. Over time, plaque rupture can decrease blood flow and increase vascular resistance, raising afterload and preload on the heart. As a compensatory mechanism, the heart undergoes hypertrophy but eventually fails in oxygen compensation, leading to tissue ischemia, injury, and infarction which decreases cardiac output and causes systemic hypoxia and multiorgan failure and death.

    Original Title

    102939917-HACVD-patho.docx

    Copyright

    © © All Rights Reserved

    Available Formats

    DOCX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    The document summarizes the pathophysiology of heart and cardiovascular disease. It describes how LDL and triglycerides damage endothelial cells, leading platelets and monocytes to adhere and abnormal proliferation of smooth muscles. This causes inflammation and narrowing of blood vessels from atherosclerotic plaque formation. Over time, plaque rupture can decrease blood flow and increase vascular resistance, raising afterload and preload on the heart. As a compensatory mechanism, the heart undergoes hypertrophy but eventually fails in oxygen compensation, leading to tissue ischemia, injury, and infarction which decreases cardiac output and causes systemic hypoxia and multiorgan failure and death.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    38 views1 page

    HACVD Patho

    Uploaded by

    Angel Filoteo
    The document summarizes the pathophysiology of heart and cardiovascular disease. It describes how LDL and triglycerides damage endothelial cells, leading platelets and monocytes to adhere and abnormal proliferation of smooth muscles. This causes inflammation and narrowing of blood vessels from atherosclerotic plaque formation. Over time, plaque rupture can decrease blood flow and increase vascular resistance, raising afterload and preload on the heart. As a compensatory mechanism, the heart undergoes hypertrophy but eventually fails in oxygen compensation, leading to tissue ischemia, injury, and infarction which decreases cardiac output and causes systemic hypoxia and multiorgan failure and death.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    You are on page 1of 1

    Pathophysiology HACVD LDL and Tryglycerides

    Damage to intimal endothelial cells

    Platelets and Monocytes adhere to injured site

    Abnormal proliferation of smooth muscles and connective tissue

    Inflammation of blood vessels

    Migration of monocytes beneath the endothelium and become macrophage

    Permeability of endothelium

    Formation of Atherosclerotic plaque (CXR: Atherosclerosis of thoracic aorta)

    Narrowing of the blood vessel lumen

    Blood flow Plaque hemmorrhage/rupture Vascular resistance

    Afterload

    Preload

    Compensatory Mechanism: Myocardial Hypertrophy

    Cardiomegaly

    Increased O2 demands

    Failure of O2 compensation

    Cardiac Tissue Ischema

    Cardiac Tissue Injury

    Cardiac tissue Infarction

    Decreased functioning contractile tissue

    Cardiac output

    Perfusion/Hypoperfusion

    Systemic Hypoxia

    Multiorgan Failure

    Death

    You might also like