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    Simpson

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    1) Suicide is prevalent in the US, with over 1.4 million adults attempting it in 2019 alone, yet there are no reliable biological indicators for suicide risk or effective treatments to prevent it. 2) Researchers have found that neuroinflammation, or increased immune system activation in the brain, is associated with suicide and suicide risk factors like depression, anxiety, impaired decision-making and memory. 3) Treatments that target neuroinflammation, such as the drug minocycline or lifestyle changes like the Mediterranean diet, yoga and reducing refined carbs and oils, may help reduce suicide symptoms by lowering inflammation in the brain.

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    Simpson

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    72 views3 pages
    1) Suicide is prevalent in the US, with over 1.4 million adults attempting it in 2019 alone, yet there are no reliable biological indicators for suicide risk or effective treatments to prevent it. 2) Researchers have found that neuroinflammation, or increased immune system activation in the brain, is associated with suicide and suicide risk factors like depression, anxiety, impaired decision-making and memory. 3) Treatments that target neuroinflammation, such as the drug minocycline or lifestyle changes like the Mediterranean diet, yoga and reducing refined carbs and oils, may help reduce suicide symptoms by lowering inflammation in the brain.

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    1) Suicide is prevalent in the US, with over 1.4 million adults attempting it in 2019 alone, yet there are no reliable biological indicators for suicide risk or effective treatments to prevent it. 2) Researchers have found that neuroinflammation, or increased immune system activation in the brain, is associated with suicide and suicide risk factors like depression, anxiety, impaired decision-making and memory. 3) Treatments that target neuroinflammation, such as the drug minocycline or lifestyle changes like the Mediterranean diet, yoga and reducing refined carbs and oils, may help reduce suicide symptoms by lowering inflammation in the brain.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    72 views3 pages

    Simpson

    Uploaded by

    api-534201968
    1) Suicide is prevalent in the US, with over 1.4 million adults attempting it in 2019 alone, yet there are no reliable biological indicators for suicide risk or effective treatments to prevent it. 2) Researchers have found that neuroinflammation, or increased immune system activation in the brain, is associated with suicide and suicide risk factors like depression, anxiety, impaired decision-making and memory. 3) Treatments that target neuroinflammation, such as the drug minocycline or lifestyle changes like the Mediterranean diet, yoga and reducing refined carbs and oils, may help reduce suicide symptoms by lowering inflammation in the brain.

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    © All Rights Reserved
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    Download as docx, pdf, or txt
    of 3

    Elainna Simpson

    Brain Brief
    Is a Treatment to Suicide Possible?

    Suicide is a prevalent issue throughout the United States. According to the National

    Institute of Mental Health, 1.4 million adults attempted suicide during 2019 alone. Despite its

    prevalence, we have no biological indicators of those who may commit suicide and no treatment

    to prevent it. Researchers have recently tried to target behaviors or symptoms associated with

    people who commit suicide in order to reduce suicide rates. The common symptoms associated

    with suicide are likely no surprise: increased stress which causes depression and anxiety-like

    behaviors, impaired decision-making, poor working memory, and increased impulsivity.

    Scientific research shows that in suicide models these symptoms are associated with an increase

    in neuroinflammation or immune system activation in the brain. Improved knowledge on this

    neuroinflammation can help to create new drug treatment options for suicidal people.

    Chronic stress can change the balance

    of the brain and body. Inflammation can occur

    to correct this imbalance, which is why

    neuroinflammation is associated with many

    neuropsychiatric diseases like depression and

    anxiety. An increase in microglia has been

    found in post mortem brains of those who

    have committed suicide. Microglia are brain

    cells that primarily make up the brain’s

    immune system. Normally microglia help


    protect brain cells, which is called neuroprotection. Yet, during chronic inflammation microglia

    can become continually activated and produce chemical messengers that keep the brain in an

    inflamed state. This inflamed state can lead to brain cell death. Researchers believe that this is

    the issue within suicide brains, and possibly what is causing suicide symptoms.

    The increase in microglia and therefore inflammation has been connected to suicide

    symptoms. Suicidal individuals are more likely to have more depressive and anxiety-like

    symptoms, increased impulsivity, poor working memory, and impaired ability to make decisions.

    These symptoms of suicidal individuals have been associated with an increase in

    neuroinflammation. There have even been attempts to target microglia to limit inflammation and

    improve these symptoms. Some researchers have utilized minocycline, which is a drug that can

    inhibit, or stop, microglial activation. When used this drug can decrease inflammation levels and

    improve the subject’s working memory and decision-making. Minocycline is still undergoing

    clinical trials as a treatment for mental health disorders and suicide.

    However, while we wait for drug development, there also are several holistic ways to

    decrease neuroinflammation which could help reduce the incidence of suicide. So what are the

    ways you can lower neuroinflammation and improve your body and mind? Yoga, meditation,

    breathing exercises, therapeutic massage with sesame oils, and changing your diet have all been

    shown to reduce inflammation levels. Refined carbohydrates (processed sugars and starches –

    sugar, corn syrup, fruit juice, cereal, etc.) and refined vegetable oils (oils extracted from seeds –

    soybean oil, sunflower oil, canola oil, etc.) have been linked to increases in inflammation. So

    instead you can reduce omega-6 fatty acids by seeking other fat sources and reducing or

    removing carbohydrates from your diet to decrease inflammation. A research team found that the

    Mediterranean diet supplemented with fish oil had increased positive mental health in depressed
    patients after three months and the results were still evident six months later. This diet, due to

    lack of refined carbohydrates and refined vegetable oils, has also been shown to have anti-

    inflammatory effects in neurodegenerative diseases, like Alzheimer’s disease. Although these

    suggestions are not a cure-all, they have been shown to reduce inflammation which could

    improve both your physical and mental health.

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