Webinar PABI Series 3 IF

Eliminate Bacteria with Sorbact®
Technology : Catch without Kill

PABI Live Webinar Series
July 19th 2020
Isra Febriani
Medical Marketing
Essity Indonesia
Hydrophobicity of Microbes
Wound pathogenic bacteria and fungi express cell
Fact :: surface hydrophobicity have certain hydrophobic
structures on their cell surfaces
Staphylococcus aureus Streptococci
Hydrophobic interaction is essential for microbial life!

For cell to cell communication (e.g. DNA exchange)
To bind to molecules for nutrition

Why do Pseudomonas aeruginosa Escherichia coli
microorganisms need To bind to surfaces to “rest“
hydrophobic surface
structures? For protection against phagocytosis
To adhere to host tissue (e.g. in the initial phase of wound
infection)
Klebsiella Citrobacter
Key component of biofilm formation
3 7/20/2020
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Sorbact® Technology : Hydrophobic Interaction
A new technology approach : DACC (dialkylcarbamoyl chloride)

The derivative of a natural fatty acid have strongly hydrophobic properties
Bound pathogens
Bacteria and / or fungi are
An infected, colonized are removed with
attracted to the DACC mesh
wound each dressing
through hydrophobic interaction
change
4 7/20/2020
Butcher, M. DACC antimicrobial technology: a new paradigm in bioburden management. MA Healthcare, 2011.
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What happens to the bound Bacteria?
Based on living proof
Irreversible Binding Action : Bacteria and fungi binding to Sorbact® fibres
─ They become inactivated = their metabolism

slows down, they "take a rest“
─ They do not continue to replicate

─ as shown in the publication of Ljungh et al.*
─ The formation of bacterial toxins also slows or

stops completely
─ supports the wound healing process
─ no release endotoxins
Magnification x 2,000 Magnification x 15,000
─ No development of antimicrobial resistance Staphylococcus aureus (yellow), Pseudomonas aeruginosa (purple), Enterococcus faecalis (blue), Klebsiella spec. (green),
Candida albicans (orange) are bound to the Sorbact dressing
*Using the principle of hydrophobic interaction to bind and remove wound bacteria. Ljungh, Yanagisawa, Wadström; Journal of
Wound Care 15 (4), 2006
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Cutimed®
Sorbact®
All dressings are designed for use in the management of
clean, contaminated, colonized or infected wounds.
Swabs
for shallow or deep wounds,
from low to excessive exudate
levels
Ribbon gauze
for cavity wounds and
fistulas. Also intended
Leukomed® Sorbact®
Surgical post-operative dressing for
for fungal infections in the reduction of bacterial
skin folds. colonization
Round swabs
Transparent film
for wound cleansing or as a wound
filler of minor cavity wounds • Effectively protects against external
contamination (bacteriaproof)
• Breathable and showerproof
Dressing pad
for shallow wounds with moderate
to high Wound pad
 Absorb dry to low exudate levels
DACC (dialkylcarbomoyl chloride)

Safety binds bacteria from the wound
• No resistance development
• No release of endotoxin
All Sorbact® dressings are indicated and
designed to manage infections.
4 things to be considered
1. The green wound contact layer should always be

applied in direct contact with the wound
2. Do not combine with oily products, such as
ointments, creams and solutions
3. Can be left in place for up to 7 days, should the
clinical condition allow (how severe is the infection
and deserve close monitoring)1)
4. Prior to radiation therapy, remove the dressing
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Evidence Based Sorbact® Technology
1 No mechanism for development of bacterial resistance has been described
Cutting and McGuire: Safe bioburden management. A clinical review of DACC technology; Journal of Wound Care; 2015
 This review contains an educational part about the Sorbact technology and an
evidence part which summarizes and gives an overview on the evidence base of
Cutimed Sorbact.
 Unlike common antimicrobial dressings, the Cutimed Sorbact range does not kill
pathogens, but instead binds them to its surface, so they can be safely removed at
dressing change. As a result, it can be used long term with minimal risk of side
effects.
 With Cutimed Sorbact it is possible to reduce inflammation by eliminating the
endotoxin release triggered by the cell-wall disruption of bacteria killed by the use of
antiseptics and antibiotics. Common antiseptics and antibiotics work in several ways
to kill bacteria. After the bacterial cell wall is ruptured, intracellular antigenic material
and cell wall endotoxins are released into the wound fluid. Following the deaths of
millions of bacteria, the wound fluid becomes decidedly inflammatory.
 Trapping bacteria onto a hydrophobic material without killing them therefore becomes
an attractive way of managing wound bioburden and improving healing.
 Bacteria will not develop resistance against a principle which helps them
survive: they need hydrophobic cell surfaces to bind to host tissues and to
nutrients.
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Evidence Based Sorbact® Technology
2 Does not kill bacteria, and thus does not trigger additional endotoxin release
Susilo YB, HusmarkJ, DACC Coated Wound Dressing and Endotoxin: Investigation on Binding Ability and Effect on Endotoxin Release from Gram-negative Bacteria. Poster presented at EWMA 2019.
 This poster describes an in vitro study to investigate the ability of Sorbact dressings to bind endotoxins. Furthermore, the effect of
Sorbact dressings and antimicrobial containing dressings (Silver, PHMB) on the endotoxin release from gram-negative bacteria was
compared.
 Incubation of endotoxin with Sorbact resulted in up to 94% lower free endotoxin concentration compared to reference
material. This indicates that endotoxin is able to bind to the Sorbact dressingin vitro.
 Neither of the tested Sorbact dressings promote the release of endotoxin. The tested antimicrobial dressings caused up to 9x
increase in endotoxin release compared to Sorbact dressings or control.
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Email :
Informasi@essity.com
Contact :
0813 1642 6682
Public

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Eliminate Bacteria with Sorbact®

Technology : Catch without Kill

Staphylococcus aureus Streptococci

Hydrophobic interaction is essential for microbial life!

To bind to molecules for nutrition

A new technology approach : DACC (dialkylcarbamoyl chloride)

─ They become inactivated = their metabolism

─ They do not continue to replicate

─ The formation of bacterial toxins also slows or

DACC (dialkylcarbomoyl chloride)

1. The green wound contact layer should always be

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