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    Aoc 2

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    irfan
    This document contains three past examination papers for a Master of Pharmacy degree in Pharmaceutical Chemistry. Each paper tests students on advanced organic chemistry concepts through essay and short answer questions. The papers assess students' understanding of reaction mechanisms, synthesis strategies, structure-activity relationships, stereochemistry, heterocyclic compounds, and other key organic chemistry topics relevant to drug development.

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    Aoc 2

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    irfan
    148 views3 pages
    This document contains three past examination papers for a Master of Pharmacy degree in Pharmaceutical Chemistry. Each paper tests students on advanced organic chemistry concepts through essay and short answer questions. The papers assess students' understanding of reaction mechanisms, synthesis strategies, structure-activity relationships, stereochemistry, heterocyclic compounds, and other key organic chemistry topics relevant to drug development.

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    aoc2

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    This document contains three past examination papers for a Master of Pharmacy degree in Pharmaceutical Chemistry. Each paper tests students on advanced organic chemistry concepts through essay and short answer questions. The papers assess students' understanding of reaction mechanisms, synthesis strategies, structure-activity relationships, stereochemistry, heterocyclic compounds, and other key organic chemistry topics relevant to drug development.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    148 views3 pages

    Aoc 2

    Uploaded by

    irfan
    This document contains three past examination papers for a Master of Pharmacy degree in Pharmaceutical Chemistry. Each paper tests students on advanced organic chemistry concepts through essay and short answer questions. The papers assess students' understanding of reaction mechanisms, synthesis strategies, structure-activity relationships, stereochemistry, heterocyclic compounds, and other key organic chemistry topics relevant to drug development.

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    of 3

    March 2009

    [KU 319] Sub. Code: 2855


    M.PHARM. DEGREE EXAMINATION
    (Regulations 2006)
    Candidates admitted from 2006-2007 onwards
    FIRST YEAR
    Branch II – PHARMACEUTICAL CHEMISTRY
    Paper II – ADVANCED ORGANIC CHEMISTRY
    Q.P. Code : 262855
    Time : Three hours Maximum : 100 marks
    Answer All questions
    I. Essay Questions : (3 x 20 = 60)
    1. a) Explain the mechanism and reactivity of addition reaction to carbon
    –hetero multiple bonds.
    b) Write a note on delocallized chemical bonding.
    c) Draw the Tablonski diagram and discuss the energy transition.

    2. a) Discuss the mechanism and reactivity of aliphatic nucleophilic


    substitution reaction with example.
    b) Give the application of Mannich reaction with suitable example.
    c) Give the stability and structure of carbon ions.

    3. a) What are the various types of pericyclic reactions, Discuss their


    mechanisms.
    b) Explain the asymmetric synthesis for preparing chiral drugs with an
    example.
    c) Discuss the synthones approach for carbon-carbon bond formation.

    II. Write Short Notes : (8 x 5 = 40)


    1. Discuss the Resonance and field effects of structure on reactivity.
    2. Give the application of combinatorial chemistry.
    3. Comment on the various reagents used for oxidation- reduction
    reactions.
    4. Discuss the Michael reaction with an example.
    5. Outline the synthesis of pyrrole and furan.
    6. Discuss the synthetic utility of Grignard reaction.
    7. Explain the phase transfer catalysis in anhydride..
    8. What are the various approaches for deprotection of groups.
    ******
    September 2009
    [KV 319] Sub. Code: 2855
    M.PHARM. DEGREE EXAMINATION
    (Regulations 2006)
    Candidates admitted from 2006-2007 onwards
    FIRST YEAR
    Branch II – PHARMACEUTICAL CHEMISTRY
    Paper II – ADVANCED ORGANIC CHEMISTRY
    Q.P. Code : 262855
    Time : Three hours Maximum : 100 marks
    Answer All questions
    I. Essay Questions : (3 x 20 = 60)
    1. a) Define heterocyclic compound. Classify them with examples.
    Explain the preparation, properties and uses of any six membered
    heterocycle compounds.
    b) Explain the importance of combinational chemistry in drug
    discovery.

    2. a) Explain different techniques for preparing chiral drugs.


    b) Explain how stereo chemistry effects the biological action of a drug.

    3. a) Explain in detail about retrosynthetic analysis.


    b) Briefly give a detailed explanation about phase transfer catalysis.

    II. Write Short Notes : (8 x 5 = 40)


    1. Discuss about stability of carbocations.
    2. Explain the importance of Mannich bases.
    3. Explain why pyridine is less basic than aliphatic amines.
    4. Explain with examples various pericylic reactions.
    5. Explain the synthesis and uses of grignard reagents.
    6. Write the mechanism involved in:
    a) Micheal reaction b) Hoffman rearrangement.
    7. Compare and explain the reactivity of furan and pyrrole.
    8. Explain the addition to carbon-carbon multiple bonds.
    ******
    March 2010
    [KW 319] Sub. Code: 2855
    M.PHARM. DEGREE EXAMINATION
    (Regulations 2006)
    Candidates admitted from 2006-2007 onwards
    FIRST YEAR
    Branch II – PHARMACEUTICAL CHEMISTRY
    Paper II – ADVANCED ORGANIC CHEMISTRY
    Q.P. Code : 262855
    Time : Three hours Maximum : 100 marks
    Answer All questions
    I. Essay Questions : (3 x 20 = 60)
    1. a) Define free radical. Explain in detail the formation of free radial.
    Explain any reaction involving free radical.
    b) Explain in detail the effect of structure on reactivity.

    2. a) Explain with examples how chirality influences the biological


    activity of a drug .
    b) Explain the techniques used to prepare chiral drugs.

    3. a) Explain in detail with mechanism about Beckman rearrangement.


    b) Discuss about aromatic electrophilic substitution.

    II. Write Short Notes : (8 x 5 = 40)


    1. Give an account of macro beads in new solid phase synthesis.
    2. Write the mechanism involved in wolf – kishner reduction.
    3. Explain hyperconjugation.
    4. Explain the importance of N-Bromosuccinamide in organic synthesis.
    5. Distinguish between SN1 and SN2 reaction.

    6. Pinacole – pinacolone rearrangement.


    7. Define hemolytic and heterolytic bond fission.
    8. Explain about fries rearrangement.
    ******

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