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    Pathophysiology Cushing S Syndrome

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    Maria Luisa Villaluna
    Cushing's syndrome is caused by excessive secretion of cortisol due to a benign tumor in the hypothalamus or pituitary gland. This leads to increased appetite, fat deposition, insulin resistance, and diabetes. Physical signs include truncal obesity, moon face, buffalo hump, thin skin and muscles, osteoporosis, and poor wound healing due to immunosuppression. Long term complications involve hypertension, infections, osteoporosis, and psychiatric problems due to sleep deprivation and altered hormone levels.

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    Pathophysiology Cushing S Syndrome

    Uploaded by

    Maria Luisa Villaluna
    110 views4 pages
    Cushing's syndrome is caused by excessive secretion of cortisol due to a benign tumor in the hypothalamus or pituitary gland. This leads to increased appetite, fat deposition, insulin resistance, and diabetes. Physical signs include truncal obesity, moon face, buffalo hump, thin skin and muscles, osteoporosis, and poor wound healing due to immunosuppression. Long term complications involve hypertension, infections, osteoporosis, and psychiatric problems due to sleep deprivation and altered hormone levels.

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    126641032 Pathophysiology Cushing s Syndrome

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    Cushing's syndrome is caused by excessive secretion of cortisol due to a benign tumor in the hypothalamus or pituitary gland. This leads to increased appetite, fat deposition, insulin resistance, and diabetes. Physical signs include truncal obesity, moon face, buffalo hump, thin skin and muscles, osteoporosis, and poor wound healing due to immunosuppression. Long term complications involve hypertension, infections, osteoporosis, and psychiatric problems due to sleep deprivation and altered hormone levels.

    Copyright:

    © All Rights Reserved
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    110 views4 pages

    Pathophysiology Cushing S Syndrome

    Uploaded by

    Maria Luisa Villaluna
    Cushing's syndrome is caused by excessive secretion of cortisol due to a benign tumor in the hypothalamus or pituitary gland. This leads to increased appetite, fat deposition, insulin resistance, and diabetes. Physical signs include truncal obesity, moon face, buffalo hump, thin skin and muscles, osteoporosis, and poor wound healing due to immunosuppression. Long term complications involve hypertension, infections, osteoporosis, and psychiatric problems due to sleep deprivation and altered hormone levels.

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    © All Rights Reserved
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    of 4

    PATHOPHYSIOLOGY OF

    Precipitating Factors
     Obesity

    Hypersecretion of CRH by
    benign tumor of hypothalamus

    Excessive secretion of
    ACTH by pituitary gland

    ↑ Serum ACTH

    ↑ Stimulation of cortisol
    synthesis

    HYPERCORTISOLISM

    ↑ Appetite Altered Fat ↑Stimulation of glucose Promotion ↑ protein


    Metabolism formation in the liver breakdown

    Mobilization of
    Fatty Acid ↑Glucose production
    in the liver Amino acid mobilized and ↑ Protein
    transferred to the liver catabolism

    Fat Deposition Converts cell Exhaustion of B cells


    metabolism from Protein wasting
    Use for glucose
    use of glucose to
    production
    use of Fatty acid ↓ Insulin (gluconeogenesis)
    production

    Peripheral
    glucose use falls Insulin resistance

    Hyperglycemia

    Around the waist face Back of the head


    (Truncal obesity) (Moonface) (Buffalo Hump) DIABETES
    MELLITUS

    In skin In muscles & extremities In blood vessel wall In bone

    ↑ Serum plasma protein level


    C U S H I N G’S S Y N D R O M E
    Predisposing factors
     Age: 10 y/o

    ↑sterilization of lysosomal Depressed


    membrane of inflammatory cells phagocytosis by WBC

    Prevents the release of ↓ Release of inflammatory


    ↑ serum plasma inflammatory mediators mediators
    protein level (prostaglandin, leukotrienes)

    Inhibits inflammatory
    Proteinuria reaction

    ↓ or absence of fever

    ↑ Susceptibility to
    infection

    Atrophy of lymphoid tissues

    ↓ B lymphocytes ↓ T lymphocytes
    Thin skin Rupture with Osteoporosis
    Thin arms & Muscle minimal trauma
    legs weakness

    Stretch marks
    Back pain

    Compression
    fracture

    Inhibits fibroblast activity enhancement of


    vasoconstrictive effect of
    circulatory
    catecholamine

    Lessen scar formation

    Vasoconstriction of
    blood vessel
    Poor wound healing

    Hypertension

    Skin ulcers
    ↓ Antibody ↓ humoral ↓ Cell mediated
    formation immunity immunity

    ↓ Immune response

    ↑Stimulation of Aldosterone synthesis ↑ Stimulation of Melanin Synthesis

    Hyperpigmentation of skin and gums


    Hyperaldosteronism

    Purpura
    Altered diurnal secretion ↑ Na & H20
    of aldosterone retention

    Disturbed sleep
    Weight gain ↑ Serum Na ↓Serum K ↑Blood volume
    Sleep deprivation
    Polydipsia Hypokalemia ↑ Blood Pressure

    Hypertension

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