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    Pharmacology Practical: (Effects of Drugs On The Ciliary Motility of Forg Oesophagus)

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    Anitha Mary Dambale
    1) The experiment tested the effects of various drugs on the ciliary motility of a frog's esophagus. 2) Acetylcholine and physostigmine, which are cholinergic agonists, increased ciliary movement, while atropine, a cholinergic antagonist, decreased movement. 3) Physostigmine had the strongest effect, reducing the time taken for ciliary movement to 14 seconds, followed by acetylcholine at 19 seconds and then atropine increasing the time to 46 seconds.

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    Pharmacology Practical: (Effects of Drugs On The Ciliary Motility of Forg Oesophagus)

    Uploaded by

    Anitha Mary Dambale
    2K views6 pages
    1) The experiment tested the effects of various drugs on the ciliary motility of a frog's esophagus. 2) Acetylcholine and physostigmine, which are cholinergic agonists, increased ciliary movement, while atropine, a cholinergic antagonist, decreased movement. 3) Physostigmine had the strongest effect, reducing the time taken for ciliary movement to 14 seconds, followed by acetylcholine at 19 seconds and then atropine increasing the time to 46 seconds.

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    pharmacologyeffectsofdrugsontheciliarymotilityofforgoesophagus-180508001105

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    1) The experiment tested the effects of various drugs on the ciliary motility of a frog's esophagus. 2) Acetylcholine and physostigmine, which are cholinergic agonists, increased ciliary movement, while atropine, a cholinergic antagonist, decreased movement. 3) Physostigmine had the strongest effect, reducing the time taken for ciliary movement to 14 seconds, followed by acetylcholine at 19 seconds and then atropine increasing the time to 46 seconds.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    2K views6 pages

    Pharmacology Practical: (Effects of Drugs On The Ciliary Motility of Forg Oesophagus)

    Uploaded by

    Anitha Mary Dambale
    1) The experiment tested the effects of various drugs on the ciliary motility of a frog's esophagus. 2) Acetylcholine and physostigmine, which are cholinergic agonists, increased ciliary movement, while atropine, a cholinergic antagonist, decreased movement. 3) Physostigmine had the strongest effect, reducing the time taken for ciliary movement to 14 seconds, followed by acetylcholine at 19 seconds and then atropine increasing the time to 46 seconds.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 6

    Pharmacology practical

    (Effects of drugs on the ciliary motility of forg oesophagus)


    By : Osama Al-Zahrani
    @OSAMA_Z96
    Introduction :
    - Cholinergic drugs causes contraction of cilia leading to increased movements.
    - Anticholinergics drugs causes paralysis of cilia leading to decreased movements.

    Objective :
    - To find out the action of certain drugs on the ciliary motility of frog oesophagus.

    Materials :
    1- Frog.
    2- Poppy seeds.
    3- Frog wooden board.
    4- Stop watch
    5- Drugs & Solution :
    A) Acetylcholine 10% : Cholinergic agonist.
    B) Physostigmine 10% : Anti-choline esterase inhibitor.
    C) Atropine 0.1% : Non-selective muscarinic agonist, or Cholinergic antagonist.
    D) Frog Ringer : Nutrient solution To keep the tissue viable.
    Materials pictures

    Frog wooden board Poppy seeds

    In Situ experiment
    Experiment results

    Serial Drug Reading 1 Reading 2 Reading 3 Mean

    1 Ringer (Control) 34 s 29 s 33 s 32 s

    2 Acetylcholine 22 s 18 s 17 s 19 s

    3 Physostigmine 14 s 14 s 14 s 14 s

    4 Atropine 43 s 46 s 51 s 46 s
    Experiment results
    50

    45

    40

    35

    30

    25

    20

    15

    10

    0
    Ringer (Control) Acetylcholine Physostigmine Atropine
    Interpretation of the results
    - The most effective drug is Physostigmine,
    because the drug take short time to increase the movement.

    - The order of the drugs depending on the shortest time as following :


    1- Physostigmine
    2- Acetylcholine
    3- Atropine

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