Trauma Case Reports 30 (2020) 100371

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Trauma Case Reports

journal homepage: www.elsevier.com/locate/tcr

Case Report

Two cases of acute anterolateral compartment syndrome following

inversion ankle injuries
Jugert Bango *, Evan Zhang, Daniel L. Aaron, Amna Diwan
Department of Orthopedic Surgery, University of Massachusetts Medical Center, 55 Lake Ave North, Worcester, MA 01655, United States of America

A R T I C L E I N F O A B S T R A C T

Keywords: Introduction: Compartment syndrome is a limb threatening, and sometimes life-threatening

Compartment syndrome medical condition. It usually occurs in high energy lower extremity injuries, commonly in the
Lower extremity younger patient with classic signs and symptoms. Pain out of proportion to exam is one of the key
Ankle injuries
elements in diagnosis. A high vigilance for signs and symptoms of this condition should be present
Fasciotomy
Orthopedics
on most physicians’ radars who treat emergency conditions, as this case report demonstrates, the
mechanism and story are not always classic.
Presentation of cases: Two cases of young, healthy adults who underwent fasciotomy for
compartment release for compartment syndrome isolated to the anterolateral compartment, but
who did not sustain a high energy trauma, but rather a twisting ankle injury.
Conclusion: Compartment syndrome can occur in young, healthy, active patients with a lower
energy twisting injury and without fracture. A high level of suspicion on the clinicians’ part will
prevent adverse outcomes to the patient.

Introduction

Compartment syndrome is a serious medical condition that must be dealt with emergently. Failure to identify and address acute
compartment syndrome may lead to amputation or even death in some cases [1]. It commonly occurs due to high energy trauma that
damages muscles and neurovascular structures within a fascial compartment, which subsequently leads to edema and increasing
compartmental pressures that can compromise local blood supply [2]. Development of acute compartment syndrome is an unusual
outcome following noncontact ankle sprains. There have only been a small number of case reports describing this uncommon
consequence [3–9].
Hence, vigilance is required on behalf of the clinician in order to prevent the likelihood of developing limb and/or life-threatening
conditions. This report describes two unique cases of acute compartment syndrome following inversion ankle injuries- a mechanism
that one would not suspect to lead to this complication. These cases demonstrate that compartment syndrome, despite being a rare
occurrence, can be a severe sequela following inversion ankle injuries.

* Corresponding author at: University of Massachusetts Medical School, 55 Lake Ave. North, Worcester, MA 01655, United States of America.
E-mail address: Jugert.Bango@umassmed.edu (J. Bango).

https://doi.org/10.1016/j.tcr.2020.100371
Accepted 1 November 2020
Available online 2 November 2020
2352-6440/© 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license
(http://creativecommons.org/licenses/by-nc-nd/4.0/).
J. Bango et al. Trauma Case Reports 30 (2020) 100371

Case presentation

Case 1

A 37-year-old male presented to the emergency department with left lower extremity pain, swelling, and paresthesias 1 day after
suffering an ankle inversion injury while playing soccer. He described the injury as his leg suddenly giving out but did not recall any
specific popping or tearing sensations. He was able to ambulate with some discomfort afterwards. Later in the evening, he began to
develop swelling along the lateral aspect of his lower extremity which did not improve with rest, ice, and elevation. Upon waking up
the following day, the pain had worsened, and he developed paresthesias along the left lower extremity which prompted his visit to the
emergency department.
On examination, the left lower extremity had intact skin. The anterolateral compartment was firm, but compressible. The
remainder of the compartments was soft and compressible. The foot was warm and well perfused with a brisk capillary refill. There was
decreased sensation in both the superficial and deep peroneal nerve distributions with the deep peroneal being more affected. Tibial
nerve sensation was intact. The patient was able to fire his extensor hallucis longus, flexor hallucis longus, tibialis anterior, gastro­
csoleus, and peroneal muscles. Muscle strength of the peroneal and tibialis anterior muscle groups on examination was graded to be 4/
5, demonstrating reduced muscle strength against moderate resistance. Pain with passive inversion of the foot was elicited, but there
was no pain with passive stretch of the great toe, tibialis anterior, or the gastrocsoleus muscles.
Radiographic imaging of the lower extremity revealed no fractures or dislocations. Anterior and lateral compartment pressures
were recorded compartment pressures were obtained with a handheld Stryker compartment pressure monitor (Stryker, Kalamazoo,
MI). Measurements obtained revealed two separate lateral compartment measurements of 80 mmHg each and an anterior compart­
ment measure of 45 mmHg. Diastolic blood pressure was 74 mmHg at time of measurement.
The patient was emergently taken to the operating room for a single incision fasciotomy. A 20 cm longitudinal incision was made
along the lateral leg. The subcutaneous tissue was dissected down to the fascial layer where a small, transverse incision was made
through the fascia in order to identify the lateral intermuscular septum. The superficial peroneal nerve was identified and protected
where it exits the deep fascia. Complete releases of the anterior and lateral compartments were performed both, proximally and
distally.
There was substantial protrusion of muscle through the fasciotomy sites and hematoma formation in the distal third of the incision,
primarily in the lateral compartment. There was a moderate amount of muscle in the lateral compartment that appeared nonviable by
its dusky color, poor consistency, incapacity to bleed, and non-contractile with electrocautery. The muscle in the anterior compartment
appeared to be viable following the same criteria. The nonviable muscle was sharply debrided and excised. The remaining musculature
appeared to be completely viable following debridement and irrigation. Negative pressure wound therapy was applied. The patient
was monitored for recurrent compartment syndrome in the anterior and lateral compartments as well as new onset compartment
syndrome in the posterior compartment with compartment checks every 4 h for 48 h following surgery.
The patient was subsequently brought the operating room 48 h later for irrigation and excisional debridement with wound closure.
Minimal hematoma and nonviable tissue were excised, and the wound was closed primarily.
At two-week follow-up, the patient had intact sensation to light touch, but had limited motor function throughout the ankle and
foot for which he was referred to physical therapy. At three months post-operatively, the patient had made a full recovery in which he
retained intact light touch sensation and regained 5/5 strength of the affected muscle groups. He was able to resume full activity with
no limitations.

Case 2

A 21-year-old male presented to the emergency department for evaluation of right lower extremity pain, swelling, and paresthesias
that occurred following an inversion ankle injury while playing lacrosse the evening prior. He was able to bear weight and ambulate
following the injury. Throughout the evening, he developed progressively worsening pain and swelling in his anterolateral leg. He
ultimately developed paresthesias over the dorsum of his foot with associated weakness in dorsiflexion which prompted his presen­
tation to the emergency department.
On examination of the right lower extremity, his skin was intact. He had firm, but compressible anterior and lateral compartments.
The posterior compartments were soft. The foot was warm and well perfused with brisk capillary refill. His sensory exam revealed
decreased sensation in the superficial and deep peroneal nerve distributions with intact sensation to light touch over the tibial nerve
distribution. He was able to appropriately fire his extensor hallucis longus, flexor hallucis longus, and gastrocsoleus. There was notably
weak, 4/5, motor strength of the tibialis anterior and peroneal muscle groups. Furthermore, there was pain with passive plantar
flexion, forefoot inversion, and passive stretch of the extensor hallucis longus.
Resting compartment measurements were not performed. Radiographic imaging of lower extremity revealed no fractures or dis­
locations. The patient was diagnosed with clinical concern for anterolateral compartment syndrome and was emergently taken to the
operating room.
A single incision fasciotomy was performed along the lateral right lower extremity. Minimal debridement of necrotic subcutaneous
tissue was performed. All four compartments were released. The muscles of the anterior, superficial and deep posterior compartment
were noted to be viable. The peroneal muscle group of the lateral compartment were noted to be noncontractile on initial evaluation.
Upon fascial release, perfusion of the peroneal muscle group improved. No debridement was performed as a result. Negative pressure
wound therapy was applied. Postoperatively, the patient reported improved pain control, return of dorsiflexion, and improved

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J. Bango et al. Trauma Case Reports 30 (2020) 100371

paresthesias of the foot. Eversion remained weak.

The patient was subsequently brought to the operating room 48 h later for irrigation and possible debridement with attempted
wound closure. On evaluation, there were scant areas of muscle or tendon that appeared dark which did not warrant debridement. The
remainder of the muscle appeared viable. Muscle contractility was evaluated with electrocautery which revealed that the anterior
compartment was contractile. However, the lateral compartment containing the peroneal muscle group did not appear to contract
despite having a viable appearance. It was elected to not perform a debridement due to the muscle appearing to be healthy. The
proximal 25% of the wound and the distal 35% of the wound were closed. The remaining portion was under too great of tension to be
closed and negative pressure wound therapy was applied. 48 h later the patient was brought to the operating room for complex closure
of the remaining portion with retention sutures. At this time, the anterior compartment remained viable and contractile. The peroneal
muscles of the lateral compartment remained viable in appearance but had now improved to be weakly contractile.
At two-week follow-up, the patient had improving sensation in the superficial and deep peroneal nerve distributions but continued
to have weak dorsiflexion of his great toe. A referral to physical therapy was made at this time. At two-months post-operatively, the
patient had regained function of his extensor hallucis longus. Furthermore, he was back to participating in lacrosse with no restrictions.

Discussion

The anatomy of the lower leg is made up of four fascial enclosed, nonelastic muscular compartments which include the anterior,
lateral, and the superficial and deep posterior compartments [13]. The lower leg and its anterior compartment are most commonly
affected by acute compartment syndrome given its relatively limited compartment compliance to accommodate expansion secondary
to hematoma or swelling [11–13]. Normal muscle tissue pressure ranges below 10–12 mmHg and capillary blood flow within the
compartment may be compromised at absolute intracompartmental pressures >30 mmHg which places muscle and nerve fibers are at
risk for ischemic necrosis [15]. When the intracompartmental pressure is within 30 mmHg of the pre-operative diastolic blood
pressure, surgical intervention becomes necessary in order to avoid ischemia and necrosis of the underlying structures [2,15].
The diagnosis of acute compartment syndrome of the lower leg is challenging and often requires high clinical suspicion in the
treating physician as no gold standard exists in making the diagnosis [15]. Elements of the patient history and physical examination,
with pain out proportion and pain on passive stretching or compression of the compartments being most common, should play a
critical role in heightening suspicion [14,15]. Intracompartmental pressure measurement is not necessary to make the diagnosis of
acute compartment syndrome but can facilitate a diagnosis when the clinical symptoms and signs are equivocal, in an unconscious or
uncooperative patient, or in a young pediatric patient [14–16].
Atypical presentations may result in a delay in diagnosis or treatment, thereby increasing the likelihood of morbidity for the patient
and medicolegal consequences [10–12]. In particular, it has been demonstrated that cases without a fracture result in a significantly
greater delay in fasciotomy than those with a fracture [8]. Lower extremity compartment syndrome, isolated to the lateral and/or
anterior compartment secondary to an ankle inversion injury, has been reported in literature [3–9]. More specifically, it has been
evidenced in the literature that these ankle inversion injuries have commonly resulted in avulsion of the peroneus longus muscle which
has led to the development of hematoma and anterior and/or lateral compartment syndrome [4,5,8,9]. In addition, avulsion of the
anterior tibial artery and perforating branches of the deep peroneal artery have been implicated as the impetus for resultant anterior
and/or lateral compartment syndrome following ankle inversion injuries [3,7].
Each of our patients suffered an ankle inversion injury while engaging in sports. The mechanism as to why the compartment
syndrome developed is unclear from our cases. It is likely that the injury to the lateral compartment muscles was the result of a primary
compressive injury due to interstitial edema or secondary to ischemic injury. Intraoperatively, there was no sign of muscle rupture or
arterial disruption and/or avulsion. In case 2, there was hematoma noted intraoperatively so it is possible that there may have been
avulsion of a small vein supplying the muscle. This could be unique to young, active adults that have a more vascularized compartment
in which a small vein is at greater risk of avulsing during a high energy twisting injury and only after significant compression does the
bleeding stop.
Rehman et al. presented a case of an individual that developed lateral compartment syndrome of the right lower extremity with no
underlying muscle rupture or arterial disruption and without obvious history of trauma or even an indirect injury such as ankle
inversion [6]. To the best of our knowledge, our cases are the first to be reported in the literature to present the development of anterior
and/or lateral compartment syndrome following an inversion ankle injury with no obvious signs of muscle rupture or arterial
involvement.
Fortunately, in our cases, extensive muscle debridement was not required. In other reported cases, however, the diagnosis was
frequently delayed or missed altogether, which subsequently led to the development of prolonged ischemia and eventual muscle
necrosis requiring significant debridement and/or limb amputation [11].

Conclusion

The cases presented in this report underscore the importance of considering compartment syndrome when individuals present with
an inversion injury of the ankle, even without fracture despite it being infrequently reported in the literature. It is imperative for
clinicians to maintain a high index of suspicion for acute compartment syndrome even when muscle rupture or arterial disruption is of
low likelihood in patients who are presenting with severe pain or worsening neurovascular symptoms. Prompt diagnosis and fas­
ciotomy can ultimately prevent devastating, irreversible patient morbidity such as muscle necrosis, foot drop, and/or limb amputation
all while minimizing medicolegal consequences.

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Consent

Written informed consent was obtained from the patients for publication of this case report.

Funding

The authors did not receive any funding for the completion of this case report.

Declaration of competing interest

The authors declare that there is no conflict of interest regarding the publication of this article.

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