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    Fresh Frozen Plasma (FFP) Dosage: Calculations For One Adult Therapeutic Dose FFP

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    Kamran Afzal
    This document provides guidance on dosing fresh frozen plasma (FFP). The recommended adult therapeutic dose of FFP is 15mL/kg, with a minimum dose of 10mL/kg. However, a national audit found that 40% of adults received less than 10mL/kg in clinical practice. The prescribed dose of FFP should be based on the patient's clinical situation and coagulation test results. Tables are provided to calculate the FFP dose in mL based on the patient's weight in kg. Caution is advised for overweight patients as the calculated dose may overestimate needs and risk fluid overload. Local massive hemorrhage protocols may have alternative FFP dosing strategies.

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    Fresh Frozen Plasma (FFP) Dosage: Calculations For One Adult Therapeutic Dose FFP

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    Kamran Afzal
    143 views1 page
    This document provides guidance on dosing fresh frozen plasma (FFP). The recommended adult therapeutic dose of FFP is 15mL/kg, with a minimum dose of 10mL/kg. However, a national audit found that 40% of adults received less than 10mL/kg in clinical practice. The prescribed dose of FFP should be based on the patient's clinical situation and coagulation test results. Tables are provided to calculate the FFP dose in mL based on the patient's weight in kg. Caution is advised for overweight patients as the calculated dose may overestimate needs and risk fluid overload. Local massive hemorrhage protocols may have alternative FFP dosing strategies.

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    This document provides guidance on dosing fresh frozen plasma (FFP). The recommended adult therapeutic dose of FFP is 15mL/kg, with a minimum dose of 10mL/kg. However, a national audit found that 40% of adults received less than 10mL/kg in clinical practice. The prescribed dose of FFP should be based on the patient's clinical situation and coagulation test results. Tables are provided to calculate the FFP dose in mL based on the patient's weight in kg. Caution is advised for overweight patients as the calculated dose may overestimate needs and risk fluid overload. Local massive hemorrhage protocols may have alternative FFP dosing strategies.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    143 views1 page

    Fresh Frozen Plasma (FFP) Dosage: Calculations For One Adult Therapeutic Dose FFP

    Uploaded by

    Kamran Afzal
    This document provides guidance on dosing fresh frozen plasma (FFP). The recommended adult therapeutic dose of FFP is 15mL/kg, with a minimum dose of 10mL/kg. However, a national audit found that 40% of adults received less than 10mL/kg in clinical practice. The prescribed dose of FFP should be based on the patient's clinical situation and coagulation test results. Tables are provided to calculate the FFP dose in mL based on the patient's weight in kg. Caution is advised for overweight patients as the calculated dose may overestimate needs and risk fluid overload. Local massive hemorrhage protocols may have alternative FFP dosing strategies.

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    Fresh Frozen Plasma

    (FFP) Dosage

    Fresh Frozen Plasma (FFP) has optimal value when transfused at the appropriate dose. The recommended adult
    therapeutic dose of FFP is 15mL/kg(1), and the dose of FFP should always be at least 10mL/kg(2); however a national
    audit showed in clinical practice 40% of adults received a FFP dose <10mL/kg(2).
    The prescribed dose of FFP should be guided by clinical situation and coagulation results(3,4,5).

    Calculations for One Adult Therapeutic Dose FFP


    FFP dose – Volume/Units†
    Patient Weight (kg)
    15mL/kg Units FFP
    50kg 750mL
    55kg 825mL 3
    60kg 900mL
    65kg 975mL
    70kg 1,050mL
    75kg 1,125mL
    4
    80kg 1,200mL
    85kg 1,275mL
    90kg 1,350mL
    95kg 1,425mL
    5
    100kg 1,500mL
    †
    Volume of FFP in a unit is variable, mean FFP unit volume = 273mLs(3).

    This document is intended as a guide to the appropriate adult dose of FFP, it is not a directive, and should not be
    used in place of clinical assessment.
    Caution should be exercised if using this chart for calculating FFP volumes for overweight patients as the volume
    suggested may be an over estimation and may risk fluid overload.
    Protocols for the Management of Massive Haemorrhage may contain alternative strategies for the adult dose of FFP;
    please refer to local guidelines as appropriate.
    For further information contact your hospital Transfusion Practitioner, Consultant Haematologist for transfusion, or
    hospital transfusion laboratory (blood bank).

    (1) 
    National Blood Transfusion Committee. Indication Codes for Transfusion – an audit tool. April 2013. Accessed at:
    http://www.transfusionguidelines.org.uk/docs/pdfs/nbtc_2014_04_recs_indication_codes_2013.pdf
    (2) 
    NHS Blood and Transplant. National Comparative Audit of the Use of Fresh Frozen Plasma: Full Report. February 2009. Accessed at:
    http://hospital.blood.co.uk/library/pdf/Audit_of_FFP_Elsewheres2009.pdf
    (3) 
    NHS Blood and Transplant. Portfolio of Components and Guidance for their Clinical Use. October 2012. Accessed at:
    http://hospital.blood.co.uk/library/pdf/components/SPN223_5_4.pdf
    (4) 
    British Committee for Standards in Haematology: Guidelines for the use of Fresh-Frozen Plasma, cryoprecipitate and cryosupernatant.
    British Journal of Haematology 2004, 126: 11-28.
    (5) 
    British Committee for Standards in Haematology: Guidelines on the management of massive blood loss. British Journal of Haematology 2006, 135(5): 634-641.

    BLC697  1314024 Version 2, November 2013

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