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    Friability Tester

    Uploaded by

    Navdeep Chaudhary
    The document discusses tablet friability testing. It explains that friability, or weight loss of tablets, can be caused by factors like sharp edges, low moisture, or insufficient binders. The test involves placing tablets in a drum that rotates at a fixed speed for a set time, then inspecting for broken tablets. Acceptance criteria require the friability tester motor speed to be within 10% of 25 rpm and specify the materials and test results required.

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    © All Rights Reserved
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    Friability Tester

    Uploaded by

    Navdeep Chaudhary
    1K views4 pages
    The document discusses tablet friability testing. It explains that friability, or weight loss of tablets, can be caused by factors like sharp edges, low moisture, or insufficient binders. The test involves placing tablets in a drum that rotates at a fixed speed for a set time, then inspecting for broken tablets. Acceptance criteria require the friability tester motor speed to be within 10% of 25 rpm and specify the materials and test results required.

    Original Title

    FRIABILITY TESTER

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    The document discusses tablet friability testing. It explains that friability, or weight loss of tablets, can be caused by factors like sharp edges, low moisture, or insufficient binders. The test involves placing tablets in a drum that rotates at a fixed speed for a set time, then inspecting for broken tablets. Acceptance criteria require the friability tester motor speed to be within 10% of 25 rpm and specify the materials and test results required.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    1K views4 pages

    Friability Tester

    Uploaded by

    Navdeep Chaudhary
    The document discusses tablet friability testing. It explains that friability, or weight loss of tablets, can be caused by factors like sharp edges, low moisture, or insufficient binders. The test involves placing tablets in a drum that rotates at a fixed speed for a set time, then inspecting for broken tablets. Acceptance criteria require the friability tester motor speed to be within 10% of 25 rpm and specify the materials and test results required.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 4

    FRIABILITY TESTER

    INTRODUCTION
     Tablet friability can be caused by several factors. Causes can
    include poor tablet design like:
    Sharp edges
    Low moisture content
    Insufficient binders.
     When there is a weight loss on sample tablets of more than
    1%, then we can say there is a problem with production
    quality.
     In this case, the pharmaceutical company must find out the
    reason behind it.
     There’s a possibility that the shape of the tablet is the cause,
    so that the design must be changed.
     Sometimes it could be due to low moisture content in the
    tablets.
     The test process involves dropping some tablets into a drum.
     This is done using a rotating wheel with a baffle over a
    specified fixed time frame.
     After that, inspection is done to find the broken tablets.
    QUALIFICATION
    Once it has been established that the equipment is properly
    installed and functioning within specified operating parameters, it
    must be shown that the friability tester can operate reliably under
    routine, minimum, and maximum operating condition

    FRIABILITY TESTER OPERATION


    1. The friability tester operation test is designed to document
    the performance of the
    2. friability tester using placebo tablets. The speed of the motor
    will be measured and recorded.
    3. The materials and instruments required for this test are
    placebo tablets, a sieve, and a tachometer. Use the following
    procedure to test friability tester operation:
    • Place a sample of 20 (6 g) placebo tablets in a No. 10 sieve and
    remove any loose dust with the aid of vacuum, or a soft brush.
    Record the placebo tablets and sieve.
    • Weigh the tablet sample, initial weight (IW), and record the
    amount and place the tablet samples in a drum.
    • Rotate the drum 100 times.
    • Remove any loose dust from the tablets then weigh tablet
    samples, final weight (FW), and record the amount in Table 7.47.
    • Calculate the % friability as follows and record the results.
     initial weight (IW) - final weight (FW)/ 100 = % friability
     % Friability = (IW - FW) - IW = 120 g - 119.05 g - 120 g = 0.792

    ELEMENTS OF FRIABILITY TESTER


    ACCEPTANCE CRITERIA
    1. REQ. MATERIAL AND TEST RESULT

    2.MOTOR SPEED AND INSTRUMENT USED


     Measure the speed of the motor with a calibrated
    tachometer. Verify that the measured speed is within ±10
    percent of the fixed speed of 25 rpm. Record the results
     Record the instrument used to measure the speed in Table 2
     Motor speed specification = 25 rpm ± 10%
    ±10% of 25 = ±2.5
    25 + 2.5 = 27.5
    25 - 2.5 = 22.5 (The measured rpm of 24 falls within ±10%.)

    Name: Pradnesh P Sandikar


    Roll no: 545

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