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Phylum Platyhelminthes (Flatworms) : Important Information
Phylum Platyhelminthes (Flatworms) : Important Information
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Fasciola
• It has operculated egg البيضه بيكون فيها زي فتحه كده
• Hermaphrodite )يعني كل خليه فيها مذكرو مؤنث مع بعض (متخنثه يعني
Life cycle
1. Eggs leave biliary tree
2. And then go to small intestine and large intestine
3. And secrete with in the stool (diagnostic stage)
4. Eggs become embryonated eggs بيض به جنينin the fresh
water over 2 weeks
5. Embryonated eggs release miracidia swim in the fresh water
till
6. Invade a suitable snail (lymnea snail) (intermediate host)
7. Developed in the snail and released cercariae
8. Cercariae encyst تتحوصلas metacercariae on vegetation
(watercress) (infective stage)
9. Vegetation is eaten by sheep or man (definitive host or
accidental definitive host)
10. Metacercariae excyst تفك التحوصل بتعهاin the duodenum
11. Metacercariae penetrate intestinal wall and goes to liver
through peritoneal cavity بتروح للكبد عن طريق العشاء البرتوني
12. Immature flukes go to liver to get nutrition on RBCs and
hepatic cells
13. And then go to biliary duct
14. Where get mature and produce eggs
In human metacercariae take 3-4 months to develope
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Schistosomiasis
Important information
• Types
1. Schistosomiasis hematobium (urinary tract)
2. Schistosomiasis mansoni
3. Schistosomiasis japonicum Intestinal tract
• Lifecycle
1. Fertilized egg secretes with stool or urine
2. With good condition the eggs hatch تفقسand release
miracidia
3. Miracidia swim and penetrate specific snail (intermediate
host)
4. In the snail stages has two generation of sporocysts يعني بيعمل
دورتين كاملتان من التكاثر الالجنسي جوه القوع او الحلزون
5. And then production and release of cercariae in water
6. Cercariae swim and penetrate human skin (definitive host)
7. Shed(remove or cut) their forked tails ذيولها المتشعبهand
become schistosomulae
8. Schistosomulae migrate تهاجرvia venous circulation to the
lung
9. And then heart and from the hear to the portal vein (liver)
10. In portal vein get mature to male and female worms
11. And eggs goes to elimination tracts
More specific information about each type
موجوده في بوربوينت مش غاوي تعب انا وكل ده بيحصل بعد وصلها للكبد
A. S.japonicum found frequently in the superior mesenteric
veins drainage the small intestine
B. S.mansoni found in superior mesenteric viens drainage the
large intestine
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Infective stage
Cercariae
Mode of transmission
Penetrate skin of human and entre the blood vessels
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Taeniasis
Parasite Definitive host Intermediate host
t.saginata Man Cattle
T.solium Man Pig
e.granulosa Dog Sheep and cattle
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Lifecycle
1. Eggs and gravid proglottids are passed with the stool
2. Eggs can survive for days to months in the environment
3. Cattle and pigs are infected by eating vegetation that had
eggs or gravid proglottids (intermediate host)
4. It reformed to oncospheres (hexans embryo) hatch and
invade the intestinal wall and migrate to the striated muscle
5. And then become cysticercus and it survive for years in the
animal meat (infection stage)
6. T.solium cysticercus called encysticercus in bovis /t.saginata
cysticercus called encysticercus in cellulosae
7. Human infected by eating raw or undercooked meat
8. Cysticersus develops over 2 months to adult tapeworms in
the intestine and it can survive for years
9. Adult worm attach to the small intestine by scolex and stay
their
Life cycle numbers
t.saginata length: 5 or less but it can reach to 25 m
t.solium length: 2-7m
adults' worms produce proglottids and become gravid بيضه او حامل
and separate from the tapeworm and migrate to the anus or
passed in the stool: approximately 6/day
t.saginata have 1,000 to 2,000 proglottids
t.solium have 1,000 proglottids
eggs contained in the gravid proglottids and release after
proglottids passed in the stool
t.saginata produce up to 100,000 eggs
t.solium produce up to 50,000 eggs
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diagnosis
difficult to diagnosis in first 3 moths
diagnosis presence of gravid proglottids (most common) and
eggs (rarely)
cysticercosis
when larval stage of t.solium (cysticersus) is present in the tissue
of human
human act as intermediate host
human can infected by t.solium eggs in food and drink or by
autoinfection
hydaitdosis
when larval stage of e.granulosus (hydatid cysticersus) is present
in the tissue of human
human act as intermediate host
human can infected by e.granulosus eggs in food and drink
prevention control
• Identification and immediate institution of enteric precaution
for person harboring (host) t.solium are essential to prevent
cysticercosis
• Education to the public to prevent contamination of soil and
animal food and water with human feces
• Inspection and detection cattle and pigs
• Prevent pigs and cattle from reaching to human feces
• Isolate patient who has t.solium until he is successful treatment
• Concurrent disinfection education (hand washing)
• Investigation of contact and source of infection
• Treatment of infected cases
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Primary prevention
For taeniasis
• Cook the meat well before eating
• Examination of cattle before slaughtering for meat
For echinococcosis
• Improve personal hygiene
• Wash food before eating it
• Treat dogs
Secondary prevention
Early diagnosis and treatment
For recapping
Animal lifecycle
Sheep Definitive host flukes
Lymnea snail Intermediate
host
Biliary tree in habitat
liver
Encysted Infective stage
metacercaria
Eang Mode of
metacercaria in transmission
food
Eggs in the stole Diagnostic stage
Human Definitive host schistosomiasis
Cercaria Infective stage
Skin penetration Mode of
transmission
Special snail Intermediate
host
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Phylum aschelminthes
(Round worms)
Species
• Small intestine
1. Ascaris lumbricoides
2. Hookworms (ancylostoma duodenale, necator americanus)
3. Strongyloides stercoralis (facultative parasite)
• Large intestine
1. Enterbius vermicularis
2. Trichuris trichiura
• Tissue nematodes
1. Trichinella spiralis
2. Wuchureria bancrofti
3. Brugia spp
4. Loa loa
5. Onchocerca volvulus
Characteristics
• Slender worm with tapering end
)يعني مسلطح مع نهايات حاده (شبه السكينه كده
• No segmentation
• Most free living
• Important decomposer in soil, oceans, and lakes
مهم للبيئه وعايش فيها
• Triploblastic (developed from all 3-germ layer)
طبقات في البيضه3 بتسلخ مرتين يعني بيعمل
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Ascaris lumricoides
Life cycle
1. Fertilized and unfertilized eggs passed with feces (diagnostic
stage)
2. Unfertilized not infective but fertilized eggs in optimum
environment start larvae stage within 18 days
3. Fertilized egg cell form rhabditid larva and then form filari
larva (infective stage)
ملحوظه األسماء ديه مش موجوده في البور وال في الموقع بس الدكتور قالهم فممكن
يكون فيهم أخطاء امالئيه
4. The eggs got swallowed (enter definitive host)
5. Larvae hatches invade the intestinal mucosa and goes to the
portal vein and then liver and from the liver to the heart and
then lung
6. Larvae stay 10 to 14 days in the lung
7. And penetrate the alveolar walls and goes to bronchial tree
and
8. Throat to be swallowed
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Prevention
• Detection and treatment of infected cases
• Proper sanitation, proper hand hygiene
• Health education to prevent soil and water contamination
with faeces
شوف لتاني مره علم ابن عمك الببي في غير التيولت غلط بيجيب امراض
هيطلع دوده من منخيره بعد كده
• Eliminating the use of nightsoil سماد الطبيعيas fertilizer for
crops
• Once the eggs in the environment they can persist for long
period of time
بنسبه للسؤال الي فوق االجابه عشان مفيش أصال تكاثر الجنسي حصل تقريبا نواه
البيضه نضجت بقيت خليه الخليه دخلت االنسان نضجت في الرئه وبعد كده راحت
األمعاء وبلغت هناك وكونوا بيض تاني
ده هوست بيحصل فيه التكاثر الالجنسي الي بيكون الخالياIntermediate host
الي بتنقل للكائن الديفنتف عشان يحصل فيه تكاثر جنسي
يارب تكون فهمت
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Ancylostoma duodenale
Life cycle
1. Eggs in the stool (diagnostic stage)
2. In good conditions after 1 to 2 days it released rhabditiform
larvae and after 5-10 days released filariform larvae
(infective stage)
3. Larvae penetrate the skin to the veins and heart and then
lung (enter definitive host)
4. And penetrate pulmonary alveoli and goes to bronchial tree
5. And throat to be swallowed
6. And then the small intestinal where it's become adult
(habitat)
7. And it lives in the lumen of the small intestine where they
attach to the intestinal wall which cause blood loss by the
host
8. Most adult worms are eliminated in 1 to 2 years, but it can
reach several years
More info
• Ancyloctoma duodenale larvae can become dormant ()ساكنه
in the muscle or intestine and infection can occur by oral or
transmammary الرضاعهrout
• necator americanus requires a transpulmonary migration
phase
بيقولك ليها مرحله بتنتقل فيها عن طريق الرئه زي اخوتها يعني
Prevention and control
• treatment of infected cases
• health education
• improve sanitation and controlled feces
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tissue nematodes
habitat in the tissue
الدكتور جه هنا وشرح الحاجة بلغبطه سيكا فهنمشي بنقط تحت بعض الن مش عندنا ليف
سيكل كامله
o double chases
• surgical diagnosis looking for antibodies
Diagnosis
1. blood sample
2. surgical diagnosis
recapping
Ascaris lumricoides Habitat Small intestine
Definitive host Man
Infective stage Fertilized egg
Diagnostic stage Eggs in the stool
Ancylostoma Habitat Small intestine
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Phylum protozoa
Characteristics
• Unicellular
• Belong to eucaryota (subkingdom )مملكة فرعيه
• Each cell is complete organism that mean each cell of
protozoa capable of perform physiological function like
1. Elimination
2. Nutrition and breathing (metabolism)
3. Reproduction
4. Locomotion طريقه الحركة
• Parasitic to human but they keep general characteristics of
their free living counter parts
ولكنها تحافظ علي الخصائص العامه لنظائرها التي تعيش بحريه،تتطفل علي البشر
مش فاهم حاجه صح وحياتك وال انا بس الدكتور متكلمش عنها اعتبرها ملغيه
• They can survive in the adverse system of the host
عايز يقولك انهم ممكن ينجوا من مناعه جسمك
Classification
احنا بنقسم تبعا لكذا حاجه مثال طريقه التنفس باالكسجين وال منغير وطريقه الحركه الغذاء
وكتير والي تحت الي الزم تعرفهم
• Aerobic and anaerobic محتاجه اكسجين وال ال
• Locomotor system
• Nutrition
• Reproduction
• Habitat
دلوقتي هنتكلم علي اهم األنواع و هناخد كام مثال ليهم
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Life cycle
علي فكره خدنها في ثانوي
In human
1. Sporozoites infect human through female anopheles
2. Sporozoites infect liver cells
3. And get mature inro schizonts
4. Schizonts rupture and release merozoites
5. After replication in the liver, parasites undergo asexual
multiplication in the erythrocytes (RBCs) but there is two
scenarios
a. Merozoites infect RBCs and cause ring stage
(trophozoites) and mature into schizonts and Schizonts
rupture releasing merozoites
b. Merozoites infect RBCS and differentiate into sexual
erythrocytic stage(gametocytes)
In female anopheles
1. Mosquito ingested gametocytes (male microgametocytes
and female macrogametocytes)
2. Parasites' multiplication in the mosquito (sporogonic cycle)
3. In the mosquito stomach, microgametocytes penetrate
macrogametocytes generating zygotes
4. Zygotes become motile an elongated ()زي سن السرنجه كده
(called ookinetes)
5. Ookinetes invade midgut wall and developed into oocysts
6. Oocytes grow and rupture and release sporozoites
7. Which find their way to mosquito's salivary glands
8. And invade humans again
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بص األول االسبرورزويتات بتروح لإلنسان عن طريقه النموسه بتطلع علي دم ومن دم
علي كبد وبتتكاثر ال جنسيا فيه عن طريقه انها تغزوا خاليا الكبد و بعد تقطعها و تطلع
الميزو زويتات الي بتغزوا كرات الدم الحمرا
في حاله بقا الغزو بتاعه كرات الدم الحمرا ممكن تحصل حاجه من االتنين يا اما تتغذي
الميزو زويت علي الخليه و تقطعها و تطلع بعد كده او تغير شكلها لمشيج مذكر او مؤنث
لما النموسه بقا بتبلع المشجين دول بيتكاثروا ال جنسيا االةل بالتضاعف خالل دوره اسمها
فوق و بعد كده بيخترقوا بعض و بيطلع الزيجوت الي بيغير شكله عشان يكون عامل زي
سن االبره و يخترق معده وبتروح للميدجت عشان تتحوصل بعد ببتقطع و عشان تتحرر
االسبوروزويتات الي بتروح لغدد النموسه و بتصيب االنسان تاني
Prevention
Primary prevention
• Environment improvement
• Anti-mosquito measures
• Anti-larval measures
• Prevent mosquito bites by nets
• Chemoprophylaxis – chloroquine
Secondary prevention
• Early diagnosis and treatment
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Medical entomology
Study of arthropods and disease they transmit
Arthropods could be vectors of disease or cause discomfort to the
human
Mosquitoes
• Female anopheles' mosquito is a vector of malaria
• Female culex mosquito is a vector of filariasis
• Female aedes is a vector of dengue and yellow fever
Fleas
Rodent fleas especial are able to transmit disease (typhus and
plague)
Ticks
Are responsible for spreading diseases such as babesiosis,
typhus, tick-born encephalitis and lyme disease
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Mites
Small mite cause scabies and burrows into outer layers of the
skin and cause itch
Mites don't carry any disease
Spiders
Most of spiders are harmless
But few species are harmful to human their bites associated with
significant pathology and rare reports of death
Scorpions
Their sting may cause death
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