Name of Drug Classification Mechanism of Action Indication Contraindication Side Effects Nursing Responsibilities

Generic Name Pharmacologic Class: Recombinant human General Indications: Contraindications: - Nausea Before:
Eposino Haematopoietic Agents erythropoietin; - For treatment of - Patients with uncontrollable - Vomiting - Check the doctor’s order
stimulates anemia, especially in severe hypertension - Fever - Gather pertinent data about the
Trade Name Therapeutic class: erythropoiesis via renal anemia resulting - Allergy to epoetin α or to - Injection Site Reaction patient’s history/allergies.
Epoetin Alfa Anti-anemic from renal function other erythropoietin agents. - Skin Rash - Perform hand hygiene and
division and
insufficiency, including - Those with combined - Hypokalemia prepare the medication.
Patient’s Dose:
differentiation of hemodialysis and non- infections - Obtain serum potassium results.
4000 iu sq STAT progenitor cells in hemodialysis of chronic If hyperkalemia is present, do not
bone marrow renal failure administer Eposino.
CV: heart failure,
Availability myocardial infarction,
Inj (pre-filled syringe) Patient's Indication: Precautions: During:
Pharmacokinetics: hypertension
2,000 IU/mL x 1 mL. For treatment of - Hyperkalemia may appear - Identify the patient.
4,000 IU/mL x 1 mL. Distribution: Vd: 9L; esophageal cancer, part during the course of
CNS: Fatigue, headaches, - Educate the patient about the
6,000 IU/mL x 1 mL. Bioavailability: 21-31% of patient’s treatment treatment.
stroke, seizures. drug, its benefits and risks.
10,000 IU/mL x 1 mL. (SC) for acute hemolytic - Eposino should be used - Administer only the prescribed
anemia. carefully for patients with dose for the patient
Excretion: Feces myocardial infarction GI: anorexia, diarrhea
Route - Inform the patient about the
(majority), urine (small - During treatment, iron
Subcutaneous Injection possible side effects.
amounts) Half-Life: 4-13 concentration serum decreases Hematologic: leukopenia - Use aseptic technique all
hr (IV) - Folic and vit b12
Contents: throughout the procedure.
- epoetin α insufficiency and ultra-high Musculoskeletal:
- recombinant human aluminum may reduce arthralgia, myalgia
erythropoietin 10,000 efficacy of Eposino
Onset: Several days
iu, albumin 2.5 mg, Skin: Pruritus, urticaria. After:
Pea serum time: 5-24 hr
sterile sodium citrate - Document the drug
(SC)
5.882 mg, sterile citric Drug Interactions: administered.
acid 0.063 mg, sterile - Cyclosporine: may - Provide iron to compensate for
sodium chloride 5.884 potentiate hypertensive effects serum iron concentration loss
mg with erythropoiesis- - Eposino should be stopped for
stimulating agents use when hyperkalemia occurs
- Dichlorphenamide: paired until the normal level is
with epoetin alfa may cause recovered.
an abnormal decrease in - Monitor for other adverse
serum potassium. reactions and report immediately
to the physician if there is any.

Source/s: Source/s: Source/s: Source/s: Source/s: Source/s: Source/s:

1) Jones & Bartlett 1) Jones & Bartlett 1) Jones & Bartlett 1) Jones & Bartlett 1) Jones & Bartlett (2015). 1) Jones & Bartlett (2015). 1) Jones & Bartlett (2015).
(2015). Nurses’ Drug (2015). Nurses’ Drug (2015). Nurses’ Drug (2015). Nurses’ Drug Nurses’ Drug Handbook. 14th Nurses’ Drug Handbook. Nurses’ Drug Handbook. 14th Ed.
Handbook. 14th Ed. Handbook. 14th Ed. Handbook. 14th Ed. Handbook. 14th Ed. Ed. Burlington, MA 14th Ed. Burlington, MA Burlington, MA
Burlington, MA Burlington, MA Burlington, MA Burlington, MA
 2) Eposino. (n.d.). 2) Eposino. (n.d.). 2) Eposino. (n.d.).
2) Eposino. (n.d.). 2) Eposino. (n.d.). 2) Eposino. (n.d.). Retrieved from mims.com: Retrieved from mims.com: Retrieved from mims.com:
2) Eposino. (n.d.). Retrieved from Retrieved from Retrieved from https://www.mims.com/ https://www.mims.com/ https://www.mims.com/
Retrieved from mims.com: mims.com: mims.com: philippines/drug/info/ philippines/drug/info/ philippines/drug/info/
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