COLLEGE OF NURSING AND PHARMACY

C-NCM 106 – PHARMACOLOGY

First Semester | AY 2021-2022
Salonga, Hale Khim B.
BS Nursing 2-B
Module 4 Requirement- Drug Study

Activities for Self-Directed Learning

Prepare the following as part of the home activity to enhance learning for the topics in this module. The output
for this home activity will be part of the portfolio that is to be submitted as the end of the semester.

1. Drug Study
A. Learning Outcomes
 Apply appropriate nursing concepts and actions holistically and comprehensively
 Implement safe and quality interventions with the client to address the health needs.
B. Description of the Activity
 Read information about the following drugs:
1. Oxytocin
2. Isoxsuprine HCl

Drug Name Classificatio Mechanism of Action Therapeutics Effects Nursing Considerations

n
Generic Name: Classes: Uterine stimulant, Indications: Side Effects:  Assess vital signs
 Oxytocin Oxytocic vasopressive, & Stimulation of uterine Oxytocin injection for baseline data.
Agents antidiuretic effects; contractions during may cause side  Monitor frequency,
Brand Name: activates G-protein- third stage of labor and effects. Tell your duration, strength
 Pitocin coupled receptors that control of postpartum doctor if any of these of contractions.
 Syntocinon trigger increases in bleeding or hemorrhage. symptoms are severe  Monitor for signs
intracellular calcium or do not go away: of uterine rupture,
levels in uterine Contraindications:  nausea which include FHR
Appearance: myofibrils, which results  Significant  vomiting decelerations,
 Injectable in uterine contractions; cephalopelvic sudden increased
solution: 10 increases local disproportion pain, loss of
units/mL in prostaglandin Some side effects can uterine
amp/vial production, which  Unfavorable fetal be serious. If you contractions,
further stimulates positions or experience any of hemorrhage, and
uterine contraction. presentations, eg, these symptoms, call rapidly developing
transverse your doctor hypovolemic
lies,which are immediately: shock.
undeliverable  rash  Maintain careful
without  hives I&O; Be alert to
conversion prior  itching potential water
to delivery  difficulty intoxication. Check
breathing or for blood loss.
 Obstetric swallowing  Report changes in
emergencies that  swelling of the vital signs and
favor surgery face, throat, FHR, specifically
tongue, lips, late decelerations,
 Fetal distress eyes, hands, and any vaginal
where delivery is feet, ankles, or bleeding
not imminent lower legs
 fast heartbeat
 Where adequate  unusual
uterine activity bleeding
fails to achieve
satisfactory Adverse Effects:
progress  Sinus
bradycardia,
 Hyperactive or tachycardia,
hypertonic premature
uterus ventricular
complexes &
 Contraindicated other
vaginal delivery, arrhythmias
eg, invasive
 cervical  Permanent
carcinoma, active CNS or brain
herpes genitalis, damage, and
total placenta death
previa, vasa secondary to
previa, & cord asphyxia
presentation or
prolapse of cord  Neonatal
seizure
 Hypersensitivity
 Neonatal
 Fetal distress, jaundice
polyhydramnios,
partial placenta  Fetal death
previa,
prematurity,  Low Apgar
borderline score (5 min)
cephalopelvic
disproportion,  Uteroplacental
previous major hypoperfusion
surgery of cervix & variable
or uterus (incl C- deceleration
section), of fetal heart
overdistension of rate
uterus, grand
multiparity,  Fetal hypoxia
invasive cervical
carcinoma,  Perinatal
history of uterine hepatic
sepsis or necrosis
traumatic
delivery  Fetal
 Hyperstimulatio hypercapnia
n of the uterus,
with strong  Severe
(hypertonic) decreases in
&/or prolonged maternal
(tetanic) systolic &
contractions, or a diastolic blood
resting uterine pressure,
tone of 15-20 increases in
mm H2O heart rate,
between systemic
contractions may venous return
occur, possibly & cardiac
resulting in output, &
uterine rupture, arrhythmia
cervical & vaginal
lacerations,
postpartum
hemorrhage,
abruptio
placentae,
impaired uterine
blood flow,
amniotic fluid
embolism, & fetal
trauma including
intracranial
hemorrhage

 Not indicated for

elective labor
induction
 Drug Name Classification Mechanism of Action Therapeutics Effects Nursing Considerations
Generic Name: Autonomic A beta-adrenergic agonist Indications: Side Effects:  Monitor for
 Isoxsuprine Nervous that causes direct Based on a review of Isoxsuprine may therapeutic
System Agent; relaxation of uterine and this drug by the cause side effects. effectiveness:
Brand Name: Beta- vascular smooth muscle. National Academy of Tell your doctor if Response to
 Vasodilan Adrenergic Its vasodilating actions are Sciences-National any of these treatment of
 Duvadilan Agonist; greater on the arteries Research and/or other symptoms are severe peripheral vascular
 Vasoprine Vasolidator supplying skeletal muscle information, the FDA or do not go away: disorders may take
than on those supplying has classified the  weakness several weeks.
Appearance: skin. It is used in the indications as follows:  dizziness Evaluate clinical
 Oral Tablet: treatment of peripheral  flushing manifestations of
10 or 20 mg vascular disease and in Possibly Effective: (feeling of arterial
 Injectable: premature labor. warmth) insufficiency.
10mg/mL in  For the relief of  upset  Monitor BP and
amp symptoms stomach pulse; may cause
associated with  vomiting hypotension and
cerebrovascular  stomach pain tachycardia.
insufficiency. Supervise
 In peripheral Adverse Effects: ambulation.
vascular disease  Hypotension  Observe both
of  Tachycardia mother and baby
arteriosclerosis  Chest pain for hypotension
obliterans,  Nausea and irregular and
thromboangitis  Severe rash rapid heartbeat if
obliterans isoxsuprine is used
(Buerger's to delay premature
disease) and labor.
Raynaud's Hypocalcemia,
disease. hypoglycemia, and
 Isoxsuprine is ileus have been
also used observed in babies
occasionally to born of mothers
 treat menstrual taking isoxsuprine.
pain or prevent  Notify physician of
premature labor adverse reactions
and inhibit (skin rash,
uterine palpitation,
contractions. flushing) promptly;
symptoms are
usually effectively
Contraindications: controlled by
 Immediately dosage reduction
postpartum; or discontinuation
presence of of drug.
arterial  Prevent orthostatic
bleeding; hypotension by
parenteral use in making position
presence of changes slowly and
hypotension, in stages,
tachycardia. Safe particularly from
use in pregnancy lying down to
(category C) or sitting upright and
lactation is not avoid standing still.
established.  Note: For treatment
of menstrual
cramps,
isoxsuprine is
usually started 1–3
d before onset of
menstruation and
continued until
pain is relieved or
menstrual flow
stops.
 Do not breast feed
 while taking this
drug without
consulting
physician.

References:
https://www.rxlist.com/consumer_oxytocin_pitocin/drugs-condition.htm
https://medlineplus.gov/druginfo/meds/a682685.html#:~:text=Oxytocin%20is%20in%20a%20class,works%20by
%20stimulating%20uterine%20contractions.
https://www.news-medical.net/drugs/Syntocinon.aspx
https://reference.medscape.com/drug/pitocin-oxytocin-343132#4
https://www.webmd.com/drugs/2/drug-8667/isoxsuprine-oral/details/list-contraindications
https://medlineplus.gov/druginfo/meds/a682831.html
https://www.drugs.com/pro/isoxsuprine-hydrochloride.html#s-34084-4
https://go.drugbank.com/drugs/DB08941
http://www.robholland.com/Nursing/Drug_Guide/data/monographframes/I052.html