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Case 1
Case 1
Patients Data:
- 5 hours PTI, patient noted soaked underwater, onset of watery vaginal discharges, associates with hypogastric pain
radiating to lumbosacral area, with uterine contraction every 30 minutes, condition persisted thus opted consult.
OVARIES
The primary female reproductive organs, or gonads, are the two ovaries. Each ovary is a solid, ovoid
structure about the size and shape of an almond, about 3.5 cm in length, 2 cm wide, and 1 cm thick. The ovaries are
located in shallow depressions, called ovarian fossae, one on each side of the uterus, in the lateral walls of the
pelvic cavity. They are held loosely in place by peritoneal ligaments. Female sex cells, or gametes, develop in the
ovaries by a form of meiosis called oogenesis. The sequence of events in oogenesis is similar to the sequence in
spermatogenesis, but the timing and final result are different. Early in fetal development, primitive germ cells in the
ovaries differentiate into oogonia. These divide rapidly to form thousands of cells, still called oogonia, which have a
full complement of 46 (23 pairs) chromosomes. Oogonia then enter a growth phase, enlarge, and become primary
oocytes. The diploid (46 chromosomes) primary oocytes replicate their DNA and begin the first meiotic division, but
the process stops in prophase and the cells remain in this suspended state until puberty. Many of the primary
oocytes degenerate before birth, but even with this decline, the two ovaries together contain approximately 700,000
oocytes at birth. This is the lifetime supply, and no more will develop. This is quite different than the male in which
spermatogonia and primary spermatocytes continue to be produced throughout the reproductive lifetime. By puberty
the number of primary oocytes has further declined to about 400,000.
An ovarian follicle consists of a developing oocyte surrounded by one or more layers of cells called follicular
cells. At the same time that the oocyte is progressing through meiosis, corresponding changes are taking place in
the follicular cells. Primordial follicles, which consist of a primary oocyte surrounded by a single layer of flattened
cells, develop in the fetus and are the stage that is present in the ovaries at birth and throughout childhood.
Beginning at puberty, follicle-stimulating hormone stimulates changes in the primordial follicles. The follicular cells
become cuboidal, the primary oocyte enlarges, and it is now a primary follicle. The follicles continue to grow under
the influence of follicle-stimulating hormone, and the follicular cells proliferate to form several layers of granulose
cells around the primary oocyte. Most of these primary follicles degenerate along with the primary oocytes within
them, but usually one continues to develop each month. The granulosa cells start secreting estrogen and a cavity,
or antrum, forms within the follicle. When the antrum starts to develop, the follicle becomes a secondary follicle. The
granulose cells also secrete a glycoprotein substance that forms a clear membrane, the zona pellucida, around the
oocyte. After about 10 days of growth the follicle is a mature vesicular (graafian) follicle, which forms a "blister" on
the surface of the ovary and contains a secondary oocyte ready for ovulation.
.
FALLOPIAN TUBE
An The uterine tubes (or fallopian tubes, oviducts, salpinx) are muscular ‘J-shaped’ tubes, found in the
female reproductive tract. They lie in the upper border of the broad ligament, extending laterally from the uterus,
opening into the abdominal cavity, near the ovaries. The main function of the uterine tubes is to assist in the transfer
and transport of the ovum from the ovary, to the uterus. The ultra-structure of the uterine tubes facilitates the
movement of the female gamete: The inner mucosa is lined with ciliated columnar epithelial cells and peg cells
(non-ciliated secretory cells). They waft the ovum towards the uterus and supply it with nutrients. Smooth muscle
layer contracts to assist with transportation of the ova and sperm. Muscle is sensitive to sex steroids, and thus
peristalsis is greatest when oestrogen levels are high. There are 2 fallopian tubes present inside the female
reproductive and each has 4 inches. The lateral a end of a fallopian tube encloses an ovary,and the medial end
opens into the uterus. The end of the tube that encloses the ovary has fimbriae, fringe- like projections that create
currents in the fluid surrounding the ovary to pull the ovum into the fallopian. Because the ovum has no means of
self-locomotion(as do sperm),the structure of the fallopian tubeensures that the ovum will be kept moving toward the
uterus.
The smooth muscle layer of the tube contractsin peristaltic waves that help propel the ovum (or zygote, as
you will see in amoment). The lining (mucos) extensively tolded and is made of ciliated is The sweeping action of
the cilia also epithelial tissue. the ovum toward the uterus. Fertilization usually takes place in the fallopian tube. If
not fertilized,ovum dies within 24 to 48 an hours and disintegrates, either in the tube or the. If fertilized, the uterus.
ovum becomes a zygote and is into the uterus; this takes about 4 to 5 days swept. Sometimes the zygote will not
reach the uterus but will still continue to develop. This is called an ectopic pregnancy; ectopic means "in an
abnormal site." The developing embryo may become implanted in the fal- lopian tube, the ovary itself, or even
elsewhere in theabdominal cavity. An ectopic pregnancy usually does not progress very long, because these other
sites are not specialized to provide a placenta or to expand to accommodate the growth of a fetus, as the uterus is.
The spontaneous termination of an ectopic pregnancy is usually the result of bleeding in the mother, and sur-gery
may be necessary to prevent maternal death from circulatory shock. Occasionally and does go to ectopic pregnancy
full term and produces a healthy baby; such an event is a credit tothe adaptability of the human body and to the
advances of medical science.
UTERUS
The uterus is a hollow, pear-shaped, muscular organ located in the pelvic cavity between the bladder and
the rectum. The uterus plays a role in three important functions: menstruation, pregnancy, and parturition. The
uterus is composed of two parts, an upper portion called the corpus (body), and a lower, narrow part called the
cervix. The fundus is that portion of the corpus which rounds into a bulging prominence at about the level at which
the fallopian tubes enter the corpus. The wall of the uterine corpus is composed of the following microscopic layers:
1. Epithelial layer, which contains no blood vessels of lymphatics. 2. Basement layer, which is a sheet of
extracellular material that functions as a filtration barrier and boundary which helps to generate and maintain tissue
structure. 3. Lamina propria, which is composed of areolar connective tissue, contains blood vessels, nerves, and,
in some regions, glands. 4. Myometrium The uterus has thick wallsa nd a small, flat, triangular-shaped cavity. its
apex is directed downard and forms the internal os which opens into the cervical canal. Blood supply is received by
the uterus from the uterine arteries which are branches of the internal iliac arteries. Lymph nodes of the uterus
include: pelvic nodes (paracervical, parametrial, common iliac, internal iliac, external iliac, sacral and aortic. The
main lymphatic trunk is the utero-ovarian (infundibulo-pelvic), which drains into the iliac and sacral nodes.
VAGINA
The vagina is situated posterior to the bladder and anterior to the rectum. It extends upward and backward
from the vaginal orifice to the uterus. The vagina is a collapsible tube, capable of great distention, composed mostly
of smooth muscle lined with a mucous membrane of stratified squamous epithelium and connective tissue (stroma)
arranged in rugae, which is ridges, wrinkles, or folds of mucous membrane. A fold of mucous membrane, the hymen,
forms a border around its external opening in the virginal state. The regional lymph nodes are: Upper two thirds of
vagina: common iliac, internal iliac, hypogastric, external iliac, sacral promontory, pelvic, NOS Lower one-third of
vagina: superficial inguinal or femoral (unilateral or bilateral). The vagina has 3 main functions which includes
provides a passageway for blood and mucosal tissue from the uterus during a woman’s monthly period receives the
penis during sexual intercourse and holds the sperm until they pass into the uterus provides a passageway for
childbirth.
The menstrual cycle is the monthly series of changes a woman's body goes through in preparation
for the possibility of pregnancy. Each month, one of the ovaries releases an egg — a process called
ovulation. At the same time, hormonal changes prepare the uterus for pregnancy. If ovulation takes place
and the egg isn't fertilized, the lining of the uterus sheds through the vagina. This is a menstrual period.
EMBRAYONIC STRUCTURE
PLACENTA- A placenta is a female organ that develops during pregnancy stage which provides oxygen,
removes waste products from the baby’s blood and gives nutrients to the fetus.
UMBILICAL CORD- The umbilical cord connects a fetus to the mother's placenta, supplying oxygen and
nutrient-rich blood while also eliminating waste.
AMNIOTIC SAC (BAG OF WATER)- The double-walled fluid-filled sac that encloses and protects the fetus in
the womb splits during the birth process, releasing its fluid.
AMNIOTIC FLUID- The protecting liquid retained by the amniotic sac of a gravid amniote is called amniotic
fluid. This fluid not only acts as a cushion for the growing fetus, but it also helps the mother and fetus
exchange nutrients, water, and metabolic products.
UTERUS- The uterus, commonly known as the womb, is an inverted pear-shaped muscle organ positioned
between the bladder and the rectum in the female reproductive system. Its purpose is to feed and house a
fertilized egg until the fetus, or child, is ready to be born.
CERVIX- The uterus's lowest portion, the cervix, connects the uterus to the vagina and creates a pathway
between the vaginal and uterine cavities.
VAGINA-The vagina serves three purposes: It's where the penis is inserted during sexual intercourse. It's the
pathway (the birth canal) through which a baby leaves a woman's body during childbirth. It's the route
through which menstrual blood leaves the body during periods.
DEFINITION OF DISEASE
PREMATURE RUPTURE MEMBRANE
Premature rupture of membranes (PROM) refers to a patient who is beyond 37 weeks' gestation
and has presented with rupture of membranes (ROM) prior to the onset of labor. Preterm premature
rupture of membranes (PPROM) is ROM prior to 37 weeks' gestation. Spontaneous preterm rupture of the
membranes (SPROM) is ROM after or with the onset of labor occurring prior to 37 weeks. Prolonged ROM
is any ROM that persists for more than 24 hours and prior to the onset of labor. At term, programmed cell
death and activation of catabolic enzymes, such as collagenase and mechanical forces, result in ruptured
membranes. Preterm PROM occurs probably due to the same mechanisms and premature activation of
these pathways. However, early PROM also appears to be linked to underlying pathologic processes, most
likely due to inflammation and/or infection of the membranes. Clinical factors associated with preterm
PROM include low socioeconomic status, low body mass index, tobacco use, preterm labor history,
urinary tract infection, vaginal bleeding at any time in pregnancy, cerclage, and amniocentesis.y during
childbirth. During periods, menstrual blood departs the body via this pathway.
`
Laboratory Test
Date Type of Patient’s Norma Significance / Interpretation
exam Result l
Value
s
4/27/2020
CBC (complete
blood count)
WBC COUNT 8. 50 4.4-11.0 NORMAL
3.75 4.5-5.1 LOW (sign of iron deficiency anemia) blood that
RBC COUNT consists RBCs.
HCT COUNT 11. 7 12.3-15.3 LOW (sign of iron deficiency anemia) blood
that consists RBCs.
HCT COUNT 14.7 35.9-44.6 (sign of iron deficiency anemia) blood that
consists RBCs.
MCV 92 80-90 NORMAL
MCH 31.1 27.5-33.2 NORMAL
MCHC 33.6 32.0-36.0 NORMAL
RDW 12.6 11.6-14.8 NORMAL
PLT 199 150-450 NORMAL
MPV 7.9 6.0-11.0 NORMAL
Glucose:
NEGATIVE NEGATIVE NORMAL
Nitrite:
NEGATIVE NEGATIVE NORMAL
Bilirubin:
NEGATIVE NEGATIVE NORMAL
Urobilinojgen: NEGATIVE NORMAL
NORMAL 0.2-0.1 mg/dl NORMAL
Diagnostic Tests
Date Type of test Patient’s result Significance/ interpretation
9/18/2019 ULTRASOUND SCAN AOG: 6 2/7 weeks FIRST TRIMESTER
1 - The mother is at risk for infection that is related to premature rupture of membrane as
evidence by watery vaginal discharge.
Generic name:
Oxytoxin Brand Therapeutic Causes potent -To induce Contraindicate d CNS: BEFORE:
in patients subarachnoi Assess baselines
name:Pitoxin class: Oxytoxin andselective orstimulate
hypersensitive ) d for vit
Pharmacolo gic stimukatio n labor hemorrhage Deter
drug.
Order: class: of - To , seizures, mine
Contraindica coma. CV: frequ
Exogeneous uterine and reduce ted when ency,
arrhythmias
Actual dosage, vaginal delivery durat
hormones mammarygland pospartum ,
sn't advised hypertensio ion,
bleeding (placenta previa, n, PVCs. stren
vasa GI: gth
previa, nvasive nause of
cervical a, contr
vomit actio
ing. ns.
GU:
abruptiopl DURING:
acenta e, Monitor B/P,
tetanic pulse, respirations,
uterine fetalheart rate,
contractio
ns,
route, smooty after carcinoma, genital postpartu intra
frequency her)es),when m uteri
muscles. expulsionof
10 units cephalopelvic hemorrha ne
oxytocinat placenta. disproportion is ge, pres
10 gtts/min - present, uterine sure,
orwhen ruptu contr
20 units Incomple te re, actio
delivery
oxytocinat or impaired ns
requires
30 gtts/min uterine (dur
invetiable conversion, asin
blood ation
transverse lie.
abortion. flow, ,
pelvic strength, frequency)
Contraindicate d hematoma q15mi
in fetal , n.
distress when increased Notify
delivery isn't afibrinoge physici
imminent, in nemia, an of
prematurity, in possibly contra
other obstetric related to ctions
emergencies, and postp that last longer
in patientswith artum than 1 min, occur
severe bleeding. more frequently
toxemia or Other: than every 2 min,
hypertonic uterine anaphy or
patterns. laxis, stop.
death fromoxytocinindu
Maintain ced w
e Use cautiously
CNS: careful
during first and
infant I&O; be
second stages of
brain alert to
labor because
damage, potentia
cervical laceration,
seizures. l
uterine rupture,
CV: water intoxication.
and maternal
bradycardi Check forblood
and fetal death
a, loss.
have been arrhythmi
reported. as, PVCs.
e Use EENT: After
cautiously, neonatal PATIENT/FAMIL
ifat all,
retinal Y TEACH ING
in
patients with hemorrha • Keep pt, family
invasive cervical ge. informed of labor
cancer and inthose Hepatic: progress.
with neonatal
previous cervical
jaundice.
oruterine
surgery (in Other:
cluding cesarean low Apgar
section), grand scores at 5
multiparity, uterine minutes,
sepsis, traumatic death.
delivery,
or
overdistende d
uterus.
DRUG STUD NMBE 4
Dayal, S. (2021, July 21). Premature rupture of membranes. StatPearls [Internet]. Retrieved
September 22, 2021, from https://www.ncbi.nlm.nih.gov/books/NBK532888/.
MediLexicon International. (n.d.). Leaking amniotic fluid: Signs and what to do. Medical News Today.
Retrieved September 22, 2021, from https://www.medicalnewstoday.com/articles/322878.
The Children's Hospital of Philadelphia. (2014, August 24). Premature rupture of membranes
(prom)/preterm premature rupture of membranes (PPROM). Children's Hospital of Philadelphia.
Retrieved September 22, 2021, from https://www.chop.edu/conditions-diseases/premature-rupture
membranes-prompreterm-premature-rupture-membranes-pprom.
Dayal, S. (2021, July 21). Premature rupture of membranes. StatPearls [Internet]. Retrieved
September 22, 2021, from https://www.ncbi.nlm.nih.gov/books/NBK532888/.
http://training.seer.cancer.gov/linksor/