Blaylock Wellness Report: Grave Dangers of Autonomic Imbalance'
Blaylock Wellness Report: Grave Dangers of Autonomic Imbalance'
blood sugar, as well as other cells that release a When activated, the parasympathetic nervous
different substance called glucagon, which raises system constricts the pupils, calms the brain, slows
blood sugar. the heart, lowers blood pressure, activates the GI
The brain contains some neurons that excite tract.
activity and others that calm. Our bodies function best when these two systems
Likewise, our immune systems have some are in balance. That’s how we were meant to be for
chemicals that increase reactions and other that stop most of our waking lives.
reactions. Today, we are seeing a number of disorders that
The autonomic nervous system is another of indicate prolonged imbalance of the autonomic
these competing systems. nervous system, where the sympathetic function
It is called autonomic because it controls things is overactive and the parasympathetic function is
that we do not consciously have to think about, such underactive.
as blood pressure, heart rate, and other involuntary In fact, the more we look at diseases, the more
functions. often we find this type of imbalance.
As noted, the autonomic nervous system Why is this dangerous?
is divided into a sympathetic system and a It is much like sitting in your car with the
parasympathetic system. accelerator pushed all the way to the floor; in time,
The sympathetic nerves control what we call this type of “overdrive” will damage the engine of
“fight-or-flight” responses, which prepare us to the car.
confront or run away from danger. This includes The brain can take high levels of activity for a
effects such as: short time, but then it begins to wear down and even
• Increased brain alertness destroy some of its structures.
• Increased heart rate The same is true of the heart and other organs
• Rise in blood pressure that are affected by the body’s sympathetic nervous
• Dilation of pupils system.
• Quieting of the gastrointestinal tract Studies have shown that overall mortality is
The parasympathetic nerves have the opposite related to autonomic imbalance, with sympathetic
effect; they prepare us for rest, calmness, and overdrive shortening both lifespan and health span —
digestion. a measure of how long a person will remain healthy.1
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March 2015 The Blaylock Wellness Report Page 3
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neurotransmitter acetylcholine, and thereby increase Other recent studies have shown that the heart’s
parasympathetic activity. This brings the autonomic ventricles have a special acetylcholine system that is
system back into balance. different from the rest of the heart. The difference is
A number of natural compounds also increase that it doesn’t need direct stimulation by the vagus
acetylcholine, including: nerve to work.
• Choline The heart cells themselves manufacture
• Acetyl-L-carnitine acetylcholine and release it into the ventricle’s
• Phosphatidylcholine muscle wall.
• Lypo-spheric vitamin C (because of the added What’s important about this special system is
phosphatidylcholine)
that the heart cells use this neurotransmitter to make
It remains to be seen if these products can the heart release another chemical called nitric oxide,
be used to treat arrhythmias, but my personal which plays a major role in protecting the heart and
experiences suggest that they work. preventing arrhythmias.
In one case, I treated a person suffering from
frequent abnormal heartbeats with acetyl-L-carnitine
in a dose of 500 mg three times a day. Exclusive to Current Subscribers
With this treatment, the patient’s arrhythmias Current subscribers have instant access to any and
stopped for good. every past edition of The Blaylock Wellness Report.
Using animal models of heart failure and Simply go here:
arrhythmias, scientists have shown that putting [Link]
the autonomic nervous system back in balance
can significantly improve heart function, prevent ThisThe
month’s
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arrhythmias, and improve overall survival of the in the
(Please introductory
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March 2015 The Blaylock Wellness Report Page 5
It can also play a critical role in regulating blood raising blood pressure to dangerous levels, and
flow to the heart muscle because nitric oxide opens bringing on a feeling of anxiety.
up the coronary arteries, allowing a better flow of If it goes on long enough, this can lead to
blood to the heart’s ventricles — the main pumps in complete heart failure.
the heart. The last thing you want is to have your body in
This nitric oxide system is critical when a prolonged sympathetic overdrive.
coronary artery is blocked, as it gives the blood And as you will see, a great number of very
another route around the blockage (called collateral common conditions can cause this autonomic
blood supply). If the coronary arteries are deficient imbalance.
in nitric oxide, the vessel constricts, cutting off the
emergency blood supply and resulting in a heart Low Blood Oxygen Causes
attack. Sympathetic Overdrive
Of course, a mere handful of cases does not So the carotid bodies play an important role in
add up to good science — but such experiences do regulating blood pressure. The next question is what
suggest that these compounds may be effective. is making them misbehave?
The bottom line is that if the heart has defective The answer is something that I have written
acetylcholine production, it becomes deficient in about a lot over the years: inflammation.
nitric oxide. Studies have shown that inflammation is a
This puts the heart at a very high risk of severe powerful trigger for sympathetic nervous system
damage when the blood supply is impaired. And it overdrive from the carotid bodies.
can lead to both arrhythmia and heart attack. As long as the inflammation persists, there will
be greater damage to the kidneys, the lungs, the
Carotid Bodies: Sensors Regulate heart, blood vessels, and the brain.
Blood Pressure and Breathing There is a very strong connection between
The question of what causes these imbalances inflammation and low oxygen levels in blood and
in the autonomic nervous system is an extremely tissues.
complex one. In fact, many aspects of the answer are This is best demonstrated in cases of sleep apnea,
still missing. a condition in which a person stops breathing
We can say, however, that one of the driving during the night, causing blood oxygen levels to fall
forces of this sympathetic-dominated imbalance is a (which is called hypoxia).
small, isolated cluster of nerve cells in the neck called This leads to inflammation in the carotid bodies,
the carotid bodies. triggering sympathetic overdrive.
These small lumps of tissue contain many blood We see similar events with chronic heart failure,
vessels and special nerves that constantly sample the wherein poor blood flow — which causes low
blood for oxygen, carbon dioxide, and pH level. In oxygen levels — produces widespread inflammation
essence, they are sensors that make sure the blood is and damages the heart and other organs.
sound. This link between low oxygen levels and
If the carotid bodies sense an oxygen deficiency, sympathetic overdrive also explain why people
signals are sent out from the cluster’s sympathetic with sleep apnea have a much higher risk of
nerves to raise the blood pressure by constricting cardiovascular diseases.
arteries. There is strong evidence that sympathetic
The carotids then send other signals to the brain overdrive can be stimulated by inflammation from
stem to increase breathing. other conditions, such as:
This is all part of our bodies’ protection system. • Arthritis
But if the sympathetic signals continue for too • Autoimmune diseases
long, they begin to cause a lot of mischief, such as • Diabetes
enlarging the heart, triggering arrhythmias, causing • Hypertension
the hands and feet to feel cold, damaging kidneys, • Kidney failure
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Page 6 The Blaylock Wellness Report March 2015
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to the newsletter. I have nothing to do with these advertisements and do not endorse them. The only
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Please note that this advice is generic and not specific to any individual. You should consult with your doctor
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the way you look at life — most importantly, not metals and chemicals, infections, aging, chronic
letting the little stuff bother you. diseases, and injury.
With your nervous system on sympathetic In most cases, a person can reduce excitotoxicity
overdrive because of stress, everything seems to by eating freshly prepared (especially organic) foods
make you angry or anxious. This interferes with and enhancing his or her diet with a few natural
sleep patterns, and that, in turn, aggravates stress supplements, such as:
substantially. • Luteolin in a dose of 50 to 100 mg taken two to
One of the ways I reduce stress is to constantly three times a day
tell myself what my Bible tells me — things of this • Magnesium citrate or malate in a dose of 500 to
world do not really matter in terms of the bigger 1,000 mg once a day taken as a sustained-released
picture. supplement
When I focus on this idea, suddenly things that • Creatine/pyruvate powder: one scoop dissolved
really bothered me before no longer seem that in water taken three times a day between meals
important. (sweeten with stevia as it is quite sour)
Not that I won’t fight for what’s right, but I do • Multi B vitamins should contain at least 20 mg
so with a positive attitude. If I lose the battle, then each of vitamins B1, B6, and riboflavin
maybe God had a different plan or one that will
benefit me in a much better way. 3. Reducing inflammation. The most important
I pray a lot and tell God my problems and ask for thing you can do is avoid foods that trigger or worsen
His help — and that relieves stress. inflammation, especially omega-6 oils such as corn,
That kind of attitude also helps with getting safflower, sunflower, peanut, soybean, and canola oils.
good, restful sleep, which is a powerful stress-reducer. These oils are easily oxidized and can produce intense
It takes some hard work to keep a positive inflammation. Sugar also stimulates inflammation.
attitude, but the payoff is worth it. On the other hand, these natural substances
reduce inflammation:
2. Reducing excitotoxicity. While eating foods • Fish oils are composed of two basic components
with high amounts of inflammatory additives — EPA and DHA. Both reduce inflammation,
is a significant source of excitotoxicity, there but DHA is more important for cells (especially
are a number of other things that can trigger brain cells) and is safer. I favor omega-3 oils that
excitotoxicity within the body. are high in DHA and have lesser amounts of EPA.
These factors include stress, exposure to toxic Take at least 1,000 mg of DHA a day.
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March 2015 The Blaylock Wellness Report Page 9
5. Enhancing parasympathetic activity. The • Hesperidin has been shown in recent studies
main neurotransmitter for the parasympathetic to selectively increase nitric oxide in the blood
nervous system is acetylcholine, a substance that is vessels, thus sparing the brain.
manufactured by neurons and other special cells,
including heart cells. Lastly, it has been shown that deep breathing
In the heart’s ventricle, heart cells use the also stimulates the parasympathetic system. In fact,
parasympathetic system to increase the level of nitric it works so well that it can stop certain types of
oxide, which protects the heart’s blood vessels and arrhythmias.
prevents heart failure. This may also explain, in part, how exercise
You can increase production of acetylcholine increases parasympathetic activity.
with the following substances: Older individuals often take shallow breaths and
• Phosphatidylcholine and choline both enhance should take deep breaths more often.
the function of the parasympathetic system. The As you can see, a great number of people are
usual dose of phosphatidylcholine is 1,000 mg affected by autonomic imbalances.
once to three times a day as needed. Choline Unfortunately, most of these people, as well
can be taken in a dose of 1 to 2 grams a day and as many of their doctors, are also unaware of the
comes in capsules of 500 mg each. High doses of associations and implications of this problem.
these two compounds can cause neck tightness It is important to recognize the part being played
with headaches. This is usually improved by by sympathetic overdrive and parasympathetic
lowering the dose. Lypo-spheric vitamin C underactivity, because these factors can do a lot to
contains 1,000 mg of phosphatidylcholine per determine a person’s chance of recovery or even
packet. survival.
• Acetyl-L-carnitine contains an acetyl component, For example, controlling sympathetic activity has
that, unlike L-carnitine, is converted into been shown to prevent and dramatically improve
acetylcholine and can rapidly enhance the potentially fatal arrhythmias, improve heart function
parasympathetic system. The dose is 250 to 500 in cases of heart failure, reduce the size of strokes
mg two to three times a day. and heart damage by coronary artery blockage and
• Curcumin has anti-inflammatory properties and dramatically improve survival of animal models of
it has also been shown to restore autonomic the human disorders.9-11
balance. Take 250 to 500 mg three times a day More importantly, stimulating parasympathetic
with meals. activity, even when the sympathetic overdrive is
• Hesperidin has been shown to reduce not reduced, can dramatically reduce the deadly
sympathetic overdrive and help bring the effects.12-14
autonomic system into balance. The dose is 500 This is great news for all of us because it is much
mg three times a day with meals. easier to boost the parasympathetic nervous system
than it is to reduce the sympathetic system.
6. Increasing nitric oxide in blood vessels and
the heart. REFERENCES
• L-arginine is an amino acid used by the body 1. Erdur, H., et. al., Cardiol 2014; 176: 206-10.
to manufacture nitric oxide. I generally do not 2. Zucker, I.H., et. al., Clin Sci (Lond) 2014; 126: 695-706.
3. Brack, K.E., et. al., Heart Fail Rev 2013; 18: 389-408.
recommend it because it increases nitric oxide in 4. Strauss, H.M., Am J Physiol Regul Integr Comp Physiol 2003; 285: R927-R931.
the brain as well as heart and blood vessels and in 5. Myers, R.W., et. al., Circulation 1974; 49: 943-47.
the brain, when oxidative stress is high, can form 6. Vanoli, E., et. al., Circ Res 1991; 68: 1471-81.
7. Gavioli, M., et. al., PLoS One 2014; 9: e100179.
a very powerful free radical called peroxynitrite. 8. De Ferrari, G.M., J Cardiovasc Transl Res 2014; 7: 310-20.
It should be taken only with the antioxidants. 9. Marcus, N.J., et. al., The Physiologist 2012; 55: C13
It has been used in a dose from 6 grams to as 10. Del Rio, R., et. al., J Am Coll Cardiol 2013: 62: 2422-30.
high as 30 grams a day. It is a powerful stimulant 11. De Ferrari, G.M., J Cardiovasc Transl Res 2014; 7: 310-20.
12. Lu, Y., et. al., J Cardiovasc Pharmacol 2014; 63: 412-20.
for insulin release and can worsen reactive 13. Zhang, Y., et. al., Circ Heart Fail 2009; 2: 692-7.
hypoglycemia. 14. Kobayashi, M., et. al., Ann Thorac Surg 2013; 96: 339-45.
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March 2015 The Blaylock Wellness Report Page 11
A: If you examine the list of complications with A: Vasculitis is an immune-mediated inflammation
ADHD medications, you’ll see these exact problems of blood vessels.
and more, including anxiety, behavioral problems, Curcumin, quercetin, apigenin, hesperidin,
hallucinations, and even paranoia. vitamin C, omega-3 oils, and a vegetable diet all
The best course is to have her tested for food reduce inflammation.
intolerances, as most of these children have one or Magnesium is also critical as it reduces
more and taking them out of the diet often cures inflammation and improves blood flow. It is
them. severely depleted with chronic inflammation.
In addition, DHA is essential. More medications
are just treating the side effects of one drug with Avoid Red Meat for RA
another. Q: I was diagnosed with severe rheumatoid
arthritis and put on three different chemotherapy
Reducing Seizures drugs, all of which caused severe side effects. Do
Q: I am a 38-year-old healthy male who has you know of anything to treat my RA?
developed grand mal seizures. Because my — Joan C., Calgary, Ont.
diagnosis was epilepsy resulting from a cavernous
malformation, does taking vinpocetine cause any A: As an autoimmune disorder, all of the
problems with a leaky blood vessel in my brain? supplements I have listed before — curcumin,
— Heath R., Poulsbo, Wash. quercetin, baicalein, magnesium, omega-3
oils, luteolin, and apigenin — will reduce the
A: There are a number of things that can reduce inflammation and block the dysfunctional immune
seizures, such as curcumin, quercetin, DHA, reaction.
magnesium citrate/malate, baicalein, and vinpocetine. Avoiding red meats and eating more vegetables
Neither vinpocetine nor those other is important.
supplements should have an adverse effect on a You should also avoid sugar, aspartame,
cavernous malformation. excitotoxins, and omega-6 oils.
Avoiding excitotoxin food additives such Vitamin C as Lypo-spheric vitamin C,
aspartame and sugar is essential. Omega-6 oils make will strengthen weakened tissues and reduce
seizures worse. inflammation.
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Page 12 The Blaylock Wellness Report March 2015
[Link]
Diet and lifestyle significantly influence the risk of autonomic imbalance by either exacerbating or alleviating sympathetic overdrive. Consuming foods with high amounts of inflammatory additives, omega-6 oils, and sugars, along with exposure to stress and environmental toxins, can increase the risk of such imbalance. Alternatively, consuming anti-inflammatory foods like omega-3 oils, probiotics, and certain vitamins can combat the effects. Positive lifestyle practices, such as stress management and avoiding neurotoxic substances, can maintain balance in the autonomic nervous system .
Natural supplements like luteolin, magnesium citrate or malate, curcumin, quercetin, and omega-3 oils help reduce excitotoxicity and inflammation. Luteolin is recommended in doses of 50 to 100 mg taken two to three times a day, magnesium citrate in 500 to 1,000 mg daily doses, and curcumin and quercetin at 250 to 500 mg three times a day. These supplements work by influencing pathways that trigger inflammation and reducing the effects of harmful oxidative processes .
Sympathetic overdrive contributes to cardiovascular disorders by causing the heart muscle to become hyperactive, leading to abnormal beating and eventually arrhythmias, which prevent proper blood circulation. This imbalance increases the risk of ventricular tachycardia and ventricular fibrillation, often resulting in sudden cardiac death. Conditions associated with sympathetic overdrive include cardiac failure, hypertension, diabetes, and severe psoriasis .
Direct vagus nerve stimulation for treating autonomic imbalance-related disorders offers potential benefits such as improving heart function and reducing arrhythmias without needing to suppress sympathetic activity. However, side effects can occur if the stimulator intensity is set too high, resulting in adverse reactions. Additionally, there are less invasive transcutaneous methods available that might mitigate some risks associated with surgical implantation .
The parasympathetic nervous system functions to counteract the sympathetic system by promoting a state of rest and digestion. It slows down the heart rate, lowers blood pressure, constricts the pupils, and activates the GI tract, essentially opposing the fight-or-flight responses of the sympathetic system. This balance is essential for maintaining bodily functions efficiently without overstrain, thus preventing the detrimental effects of sustained sympathetic activity, such as chronic disease and shortened lifespan .
Prolonged sympathetic overdrive poses risks such as damage to brain structures and other organs involved in involuntary functions due to high levels of activity. This imbalance can lead to increased mortality as sympathetic overdrive is a major contributor to arrhythmias, heart failure, and other severe health conditions. The overdrive acts much like a car in overdrive, eventually leading to the 'engine' wearing out. Studies link autonomic imbalance to a shortened lifespan and reduced health span due to premature organ fatigue and failure .
Treatment strategies for addressing autonomic imbalance involve the use of drugs like beta blockers to suppress sympathetic activity and stimulate the vagus nerve as part of the parasympathetic system. Direct vagus nerve stimulation can be achieved with surgical implantation or a transcutaneous system that works through the skin. Additionally, increasing acetylcholine levels with drugs or natural compounds like acetyl-L-carnitine can potentially restore balance in the autonomic nervous system .
Stimulating parasympathetic activity naturally can be achieved by increasing levels of acetylcholine, the neurotransmitter used by the parasympathetic system. This can be done through natural supplements like choline, acetyl-L-carnitine, and phosphatidylcholine, which boost acetylcholine production. These compounds can help restore balance in the autonomic nervous system and counteract the overdrive effects of sympathetic activity .
Heart rate variability plays a crucial role in assessing autonomic nervous system balance by measuring the variation between heartbeats (RR measure). This assessment helps determine which autonomic system, sympathetic or parasympathetic, is predominant. An electrocardiogram (EKG) is used to analyze the heart rate variability, where parasympathetic dominance results in low-frequency heart rates, while sympathetic dominance leads to high frequency .
Preventing ventricular arrhythmias is critical in managing heart failure because these erratic heartbeats can lead to sudden cardiac death by interrupting effective blood circulation. The new approach suggested for prevention involves stimulating the vagus nerve to induce parasympathetic activity, which can stabilize heart function and reduce arrhythmias. This method can be more effective than merely suppressing sympathetic activity through drugs and could lead to better long-term outcomes by rebalance of the autonomic nervous system .