Aiga 097-17 Ref Guide On Medical Gases Cylinder Valves

REFERENCE GUIDE ON
MEDICINAL GAS
CYLINDER VALVES
AIGA 097/17
Asia Industrial Gases Association

52 Jurong Gateway Road,JEM, #15-02, Singapore 608550
Tel : +65 6276 0160 • Fax : +65 6274 9379
Internet : http://www.asia.org
AIGA 097/17
REFERENCE GUIDE ON
MEDICINAL GAS CYLINDER VALVES
Acknowledgement
This document is an AIGA’s own publication and has not been harmonized with other regional
gas associations.
Disclaimer
All publications of AIGA or bearing AIGA’s name contain information, including Codes of Practice, safety procedures and other technical
information that were obtained from sources believed by AIGA to be reliable and/ or based on technical information and experience
currently available from members of AIGA and others at the date of the publication. As such, we do not make any representation or
warranty nor accept any liability as to the accuracy, completeness or correctness of the information contained in these publications.
While AIGA recommends that its members refer to or use its publications, such reference to or use thereof by its members or third
parties is purely voluntary and not binding.
AIGA or its members make no guarantee of the results and assume no liability or responsibility in connection with the reference to or
use of information or suggestions contained in AIGA’s publications.
AIGA has no control whatsoever as regards, performance or non performance, misinterpretation, proper or improper use of any
information or suggestions contained in AIGA’s publications by any person or entity (including AIGA members) and AIGA expressly
disclaims any liability in connection thereto.
AIGA’s publications are subject to periodic review and users are cautioned to obtain the latest edition.
 To be reproduced with permission from Asia Industrial Gases Association. All rights reserved.
ASIA INDUSTRIAL GASES ASSOCIATION

52 Jurong Gateway Road,JEM, #15-02, Singapore 608550
Tel: +65 62760160 Fax: +65 62749379
Internet: http://www.asiaiga.org
AIGA AIGA 097/17
Contents
1. Introduction .......................................................................................................................... 2
2. Scope & Purpose ................................................................................................................. 2
3. Definitions & Terminology ..................................................................................................... 2
4. Principles of Medicinal Valve Selection and Operation .......................................................... 2
4.1. Discriminating ...................................................................................................................... 2
4.2. Safety & Cleanliness ............................................................................................................ 3
4.3. Product Integrity ................................................................................................................... 3
5. Recommendations on Selection & Usage of Valves .............................................................. 3
5.1. Minimum Pressure Retaining (MPR) valve (also known as Residual Pressure Valve (RPV)) . 3
5.2. Valve Integrated Pressure Regulator (VIPR) / Integrated valves ........................................... 3
6. Best practices ...................................................................................................................... 3
6.1. Valve Integrity ...................................................................................................................... 3
6.2. Valve Refurbishment & Replacement Cycle .......................................................................... 3
6.3. Valve Operation ................................................................................................................... 3
6.4. Valve Protection ................................................................................................................... 3
7. References…………………………………………………………………………………………… 4
Appendix 1: Survey of Medicinal Cylinder Valve........................................................................... 5
1
AIGA AIGA 097/17
1. Introduction
Many medicinal gases are used in medical facilities such as hospitals, medical clinics, healthcare
facilities and homecare. It is of primary importance that medicinal gas cylinders be distinguished
from gas cylinders for industrial use because of their impact on the patient’s life and safety.
The outlet type of the cylinder valve is the key to connecting the correct medicinal gas to the
corresponding equipment such as respiratory apparatus. The correct choice of cylinder valve
could reduce the medicinal gas incidents due to gas mix-ups, wrong connections to the gas outlet
and so on.
2. Scope & Purpose

The purpose of this document is to provide guidelines for minimum standards in the selection of
cylinder valve types for medicinal gas service. The valves for portable liquid containers are
excluded. For guidelines on these container types see AIGA 016, Safety Features of Portable
Cryogenic Liquid Containers for Industrial and Medical Gases [1]1 or AIGA 019, Connections for
portable liquid cylinders [2].
This document presents the principles for the selection and usage of medicinal gas cylinder
valves, with recommendations and industry best practices.
3. Definitions & Terminology
Terminology:
– Shall indicates that the procedure is mandatory. It is used wherever the criterion for conformance
to specific recommendations allows no deviation.
– Should indicates that a procedure is recommended.

– May and Need not indicate that the procedure is optional.
– Will is used only to indicate the future, not a degree of requirement.
– Can indicates a possibility or ability.
4. Principles of Medicinal Valve Selection and Operation

Valves meant for medical service (for both small and large cylinders ) should comply with ISO
10297, Gas Cylinder-Cylinder Valves-Specification & Type Testing [3]. However, specific country
regulatory requirements should also be met with regard to the selection and installation of
medicinal cylinder valves.
4.1 Discriminating
Purpose: Discriminating to differentiate medicinal gas from industrial gas as well as
to avoid mix-ups of different medicinal gas types.
• As pin-index connections are unique to the gas type, this is the most effective
measure to prevent cylinder mix-up at the cylinder connection including outlets,
regulators and so on. Pin index valves are only in use for medicinal gases, hence
they distinguish medicinal gas cylinders from gas cylinders for industrial use. The pin-
index is defined in ISO 407:2004, Small Medical Gas Cylinder Pin Index Yoke-type
Valve Connections [4]. Small cylinders are defined as those with a capacity of less
than 10L in ISO 407.
1 References are shown in bracketed numbers and are listed in order of appearance in the reference
section
2
AIGA AIGA 097/17
Note: Do not modify the yoke on the pin index valve.
• Chrome-plated valves for all medicinal gases with the exception of those containing
carbon monoxide (CO).
4.2 Safety and Cleanliness

• Valve seat material: Non-toxic (non-halogenated polymer)
• Oxidation prevention: Chrome plated valves
• No valve adaptors to be used
• No reuse of gaskets, especially plastic ones for medical oxygen
• Visual check of the cylinder valves for deformation, damage, foreign objects, etc.
4.3 Product Integrity

• Use of tamper-evident seals (for example, caps, cable ties, shrinkwrap)
5. Recommendations for Selection and Usage of Valves

5.1. Valves with parallel threads are recommended for use with aluminium cylinders.
• This would prevent the scenario where the aluminium cylinder neck thread seizes
onto the valve’s brass thread when over-tightened.
5.2. Residual Pressure Valve (RPV), also known as Minimum Pressure Retaining (MPR) valve.
• Maintains positive pressure within the cylinder, thus avoiding atmospheric
contamination from entering the cylinder in case the cylinder valve is left open.
Note: Cylinders fitted with RPVs shall still be evacuated and/or purged before filling.
5.3. Valve Integrated Pressure Regulator (VIPR) or Integrated valve

• Adjusts the gas flow rate and maintains positive pressure within the cylinder which
avoids atmospheric contamination as mentioned above. Note: Use of RPV/MPR or
VIPR equipped with a non return device could eliminate the need for inverting small
medical oxygen cylinders before filling.
6. Best Practices
6.1. Valve Integrity

• 100% valve leak testing every fill cycle
6.2. Valve Refurbishment & Replacement Cycle

After hydrostatic testing, medicinal gas cylinders should be installed with new valves
or refurbished valves. Do not re-use unserviced valves.
6.3. Valve Operation

(a) Use spindle key or handwheel type valves
(b) If using spindle key, do not over-torque by using lever extension. Follow torque
levels as per manufacturer‘s instructions.
(c) Open and close valves slowly.
• High gas volume and velocity will result in higher wear and tear of valves.
(d) One-time connection when gasket or washer is used (i.e. no re-use).
6.4. Valve Protection
3
AIGA AIGA 097/17
Valve guards or valve caps shall be used on all cylinders with a neck ring provision to
accommodate valve protection. This can:
• protect valves from damage during transportation and handling.
• facilitate ease and safety of cylinder handling
Note: Valve protection should not impede the attachment of regulator or other accessories.
7. References
Unless otherwise specified, the latest edition shall apply.
[1] AIGA 016, Features of Portable Cryogenic Liquid Containers for Industrial and Medical
Gases, www.asiaiga.org
[2] AIGA 019, Connections for portable liquid cylinders, www.asiaiga.org
[3} ISO 10297, Gas Cylinder-Cylinder Valves-Specification & Type, www.iso.org
[4] ISO 407:2004, Small Medical Gas Cylinder Pin Index Yoke-type Valve Connections,
www.iso.org
[5] AIGA 063, Use of Residual Pressure Valves, www.asiaiga.org
[6] ISO 10297, Gas Cylinder-Cylinder Valves Specification and Type Testing, www.iso.org
4
AIGA AIGA 097/17
Appendix 1: Survey of Medicinal Gas Cylinder Valves
A survey of Medicinal Gas Cylinder valves was conducted in the countries in Asia. The results are
listed below.
Findings of medicinal gas cylinder valves survey

Country Regulated Industry Norm
• 15383-2011 :Connection types and
China Yes
dimensions for gas cylinder valve outlets
• ISO 407 for pin index
Hong Kong Yes
• BS EN 850 : 1997
• IS 3224 : 2002 Valve Fittings for Compressed Gas
Cylinders Excluding Liquefied Petroleum Gas
(LPG) Cylinders – Specification
• IS 7302 : 1974 Specification for Valve Fittings for
India Yes
Gas Cylinder Valves for Use with Breathing
Apparatus
• IS 3745 : 2006 Specification for Yoke Type Valve
Connection for Small Medical Gas Cylinders
Indonesia Yes • BS341 Transportable gas container valves,
• ISO 407 (Pin-index) for less than 10L medical gas
Japan Yes
cylinders, JIS B 8246
• KS B 6214 Valve for High Pressure Cylinder
Korea Yes
(specifies inlet/outlets and tests required)
• MS ISO407:2004 Recommend pin-index valves for
medical gases.
Malaysia Yes
• ISO 5145 Cylinder valve outlets for gases and gas
mixtures — Selection and dimensioning
• PNS 296:1990 Standard Valve Outlets for High
Philippines No
Pressure Permanent and Liquefiable Gases
Singapore No • BS341 Transportable gas container valves,
Taiwan Yes • CGA V-1 and JIS B 8246
Thailand Yes • CGA V-1, TIS 1095 and TIS 255
Vietnam No • BS 341 Transportable gas container valves

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REFERENCE GUIDE ON

Asia Industrial Gases Association

ASIA INDUSTRIAL GASES ASSOCIATION

Appendix 1: Survey of Medicinal Cylinder Valve........................................................................... 5

2. Scope & Purpose

3. Definitions & Terminology

– Should indicates that a procedure is recommended.

– Will is used only to indicate the future, not a degree of requirement.

– Can indicates a possibility or ability.

4. Principles of Medicinal Valve Selection and Operation

Note: Do not modify the yoke on the pin index valve.

4.2 Safety and Cleanliness

4.3 Product Integrity

5. Recommendations for Selection and Usage of Valves

5.3. Valve Integrated Pressure Regulator (VIPR) or Integrated valve

6.1. Valve Integrity

6.2. Valve Refurbishment & Replacement Cycle

6.3. Valve Operation

6.4. Valve Protection

Unless otherwise specified, the latest edition shall apply.

[2] AIGA 019, Connections for portable liquid cylinders, www.asiaiga.org

[3} ISO 10297, Gas Cylinder-Cylinder Valves-Specification & Type, www.iso.org

[5] AIGA 063, Use of Residual Pressure Valves, www.asiaiga.org

Appendix 1: Survey of Medicinal Gas Cylinder Valves

Findings of medicinal gas cylinder valves survey

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